Amyloid beta (Aβ or Abeta) is the main component of the amyloid plaques that cause the gradual death of neurons, leading to the onset of Alzheimer's disease.
Alzheimer's disease is a common form of dementia or neurodegenerative disease found in the elderly.
Alzheimer's disease is a type of dementia correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
According to the statistics, the disease is most prevalent in the elderly. Approximately 5.7 million Americans of all ages are living with Alzheimer's. 15.9 million family caregivers provide an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Alzheimer's disease is caused by a combination of genetic, lifestyle, and environmental factors that affect the neurons of the brain over time. However, less than 10% of patients with AD are associated with a genetic preposition. Patients with such mutated genes on chromosomes 21, 14, and 1are virtually guaranteed to develop the disease.
More precisely, Alzheimer's disease is caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
Dementia is a group of neurodegenerative diseases caused by a decline in mental ability in the older population that is severe enough to interfere with daily life, such as memory loss.
Compared to dementia, neurological disorders are a class of brain disease associated with reduced function of the brain, depending on the region of the neurons that were affected.
Dr. Rudolph E. Tanzi said, "The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (<60 years) familial AD, which represents ∼5% of AD. On the other hand, common gene polymorphisms, such as the ε4 and ε2 variants of the APOE gene, can influence susceptibility for ∼50% of the common late-onset AD".
And, " These four genes account for 30%–50% of the inheritability of AD".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of neurodegenerative disorders, researchers examined the effect of cranberry extract (CE) on the Alzheimer's disease (AD)associated with the aggregation and toxicity of proteins β-amyloid (Aβ).
The study is to compare the effects of berry crude extracts (CE) that yield anthocyanins-free (ACF) and anthocyanins-enriched (ACE) extracts.
According to the tested analysis, the berry ACEs (at 100 μg/mL) showed superior free radical scavenging, reactive carbonyl species trapping, and anti-glycation effects, compared to ACFs.
Furthermore, the berry ACEs at a dose of 100 μg/mL inhibited both thermal- and reactive carbonyl species (methylglyoxal; MGO)-induced Aβ fibrillation associated with the production of pro-inflammatory cytokines.
In BV-2 microglia, the berry ACEs at a dose of 20 μg/mL reduced H₂O₂-induced reactive oxygen species production and lipopolysaccharide-induced nitric oxide species.
Based on the findings, researchers said, "The free radical scavenging, reactive carbonyl trapping, anti-glycation, anti-Aβ fibrillation, and microglial neuroprotective effects of these berry extracts warrant further in vivo studies to evaluate their potential neuroprotective effects against AD.".
Taken altogether, berries including cranberry processed abundantly anthocyanins may be considered remedies for the prevention of β-Amyloid Aggregation against the onset of AD, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects by Ma H1,2,3, Johnson SL4,5, Liu W6, DaSilva NA7,8, Meschwitz S9, Dain JA10, Seeram NP. (PubMed)
(2) The Genetics of Alzheimer Disease by Rudolph E. Tanzi. (NCBI)
Saturday, August 28, 2021
Tuesday, August 24, 2021
11 Health Benefits of Phytochemical Tocopherols
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
Health benefits
1. Antioxidative, anti-inflammatory, and anticarcinogenic activities
In the examination of the inhibition of inflammation as well as of cancer formation and growth in the lung and colon in animal models., using a-tocopherol mixture that is rich in gamma-T (gamma-TmT, which contains 57%gamma-T), found that when given in the diet at 0.3%, gamma-TmT inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of human lung cancer cell H1299 xenograft tumors. gamma-TmT also decreased the levels of 8-hydroxydeoxyguanosine, gamma-H2AX, and nitrotyrosine in tumors. More evident anti-inflammatory and cancer preventive activities of dietary gamma-TmT were demonstrated in mice treated with azoxymethane and dextran sulfate sodium. These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols, according to "Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols" by Yang CS, Lu G, Ju J, Li GX.(1)
2. Cancer prevention
The study of the cancer-preventive activities of tocopherols and tocotrienols, indicated that a gamma-tocopherol-rich mixture of tocopherols inhibits colon, prostate, mammary, and lung tumorigenesis in animal models, suggesting that this mixture may have a high potential for applications in the prevention of human cancer. In this review, we discuss biochemical properties of tocopherols, results of possible cancer-preventive effects in humans and animal models, and possible mechanisms involved in the inhibition of carcinogenesis. Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research, according to "Cancer-preventive activities of tocopherols and tocotrienols" by Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, Yang CS.(2)
3. Bone formation
In the investigation of the antioxidant and anti-inflammatory properties of Alpha- and gamma-tocopherol, the two predominant isomers of vitamin E and their effects on bone metabolism, found that gamma-tocopherol may uncouple bone turnover, resulting in more bone formation than resorption. Vitamin E supplements in the form of alpha-tocopherol suppress serum gamma-tocopherol levels and may have negative effects on bone formation. Further research is needed to investigate the potential anabolic effect of gamma-tocopherol from food sources on bone, according to "Effects of vitamin E on bone turnover markers among US postmenopausal women" by Hamidi MS, Corey PN, Cheung AM.(3)
4. Liver fibrosis
In the study of Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells, found that significant cell detachment was also observed in δ-tocopherol- and tocol-treated HSCs. Decreased protein expressions of α-smooth muscle actin and β1 integrin were observed in a dose-dependent manner. These results indicate that δ-tocopherol and tocol induce anoikis in activated HSCs, according to "Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells" by Yamaguchi N, Mezaki Y, Miura M, Imai K, Morii M, Hebiguchi T, Yoshikawa K.(4)
5. Antioxidant and Antidiabetic Activities
In the determination of the antioxidant and antidiabetic activities of proximate composition, amino acids, fatty acids, tocopherols, sterols, glucosinolate and phenolic content in extracts, found that all examined extracts were prominently rich in phenolics and glucosinates, and they showed potent antidiabetic and antihemolytic activity. The present study could be helpful in developing medicinal preparations for the treatment of diabetes and related symptoms, according to "Compositional Studies: Antioxidant and Antidiabetic Activities of Capparis decidua (Forsk.) Edgew" by Zia-Ul-Haq M, Cavar S, Qayum M, Imran I, de Feo V.(5)
6. Breast cancer
in the investigation of the breast cancer effect of vitamin E, consisting of eight different variants: α-, β-, γ-, and δ-tocopherols (saturated phytyl tail) and α-, β-, γ-, and δ-tocotrienols (unsaturated phytyl tail), indicated that γ-tocopherol, and more recently δ-tocopherol, have shown greater ability to reduce inflammation, cell proliferation, and tumor burden. Recent results have shown that γ-enriched mixed tocopherols inhibit the development of mammary hyperplasia and tumorigenesis in animal models, according to "Chemopreventive Activity of Vitamin E in Breast Cancer: A Focus on γ- and δ-Tocopherol" by Smolarek AK, Suh N.(6)
7. Colon cancer
In the investigation of the effects of both alpha and gamma-tocopherol on the expression of PPARgamma mRNA and protein in SW 480 colon cancer cell lines and measurement of the intracellular concentrations of vitamin E in SW 480 colon cancer cell lines, found that both alpha and gamma-tocopherol can upregulate the expression of PPARgamma which is considered an important molecular target for colon cancer chemoprevention, according to "Gamma (gamma) tocopherol upregulates peroxisome proliferator-activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines" by Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K.(7)
8. Antioxidant defense
in the study of salmon, a rich source of marine n-3 fatty acids, which may increase oxidative stress and, in turn, and its affect the antioxidant defense system in blood plasma and erythrocytes of pregnant women, found that besides, a concomitant increase in selenium and glutathione concentration, as well as glutathione peroxidase and reductase activities, were detected as the pregnancy progressed. However, tocopherols, retinol, β-carotene, and coenzyme Q(10) decreased in late pregnancy. Collectively, our findings lead to the hypothesis that increased farmed salmon intake may increase antioxidant defenses during pregnancy, according to "Does Consumption of Two Portions of Salmon Per Week Enhance the Antioxidant Defense System in Pregnant Women?" by García-Rodríguez CE, D Mesa M, Olza J, Vlachava M, Kremmyda LS, Diaper ND, Noakes PS, Miles EA, Ramírez-Tortosa MC, Liaset B, Frøyland L, Rossary A, Farges MC, Vasson MP, Aguilera CM, Helmersson-Karlqvist J, Godfrey KM, Calder PC, Basu S, Gil A.(8)
9. The antioxidant and anti-inflammatory activities
In the investigation of the antioxidant and anti-inflammatory actions of tocopherols in mice and determination of whether the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is involved in these activities, indicated that the antioxidant and anti-inflammatory activities of γ-TmT in the colon are mostly due to the direct action of tocopherols in trapping reactive oxygen and nitrogen species, independent of the antioxidant enzymes and anti-inflammatory proteins that are regulated by Nrf2; however, Nrf2 knockout appears to affect the serum levels of tocopherol metabolites, according to "The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice" by Li G, Lee MJ, Liu AB, Yang Z, Lin Y, Shih WJ, Yang CS.(9)
10. Cognitive effects
In the examination of the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopheryl quinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopheryl quinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people, found that compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD, according to "Tocopherols and tocotrienols plasma levels are associated with cognitive impairment" by Mangialasche F, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M, Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P; AddNeuroMed Consortium. (10)
11. Renal effects
In the examination of whether γ-tocotrienol (GT3) protects against mitochondrial dysfunction and renal proximal tubular cell (RPTC) injury caused by oxidants, showed that report demonstrating the protective effects of GT3 against RPTC injury by 1) decreasing the production of ROS, 2) improving mitochondrial respiration, coupling, ΔΨ(m), and F₀F₁-ATPase function, 3) maintaining ATP levels, and 4) preventing RPTC lysis. Our data suggest that GT3 is superior to AT in protecting RPTCs against oxidant injury and may prove therapeutically valuable for preventing renal injury associated with oxidative stress, according to "γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death" by Nowak G, Bakajsova D, Hayes C, Hauer-Jensen M, Compadre CM.(11)
12. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20716280
(2) http://www.ncbi.nlm.nih.gov/pubmed/19748925
(3) http://www.ncbi.nlm.nih.gov/pubmed/22308007
(4) http://www.ncbi.nlm.nih.gov/pubmed/22293208
(5) http://www.mdpi.com/1422-0067/12/12/8846/
(6) http://www.ncbi.nlm.nih.gov/pubmed/22254089
(7) http://www.ncbi.nlm.nih.gov/pubmed/14521714
(8) http://www.ncbi.nlm.nih.gov/pubmed/22229304
(9) http://www.ncbi.nlm.nih.gov/pubmed/22226829
(10) http://www.ncbi.nlm.nih.gov/pubmed/22192241
(11) http://www.ncbi.nlm.nih.gov/pubmed/22040679
Health benefits
1. Antioxidative, anti-inflammatory, and anticarcinogenic activities
In the examination of the inhibition of inflammation as well as of cancer formation and growth in the lung and colon in animal models., using a-tocopherol mixture that is rich in gamma-T (gamma-TmT, which contains 57%gamma-T), found that when given in the diet at 0.3%, gamma-TmT inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of human lung cancer cell H1299 xenograft tumors. gamma-TmT also decreased the levels of 8-hydroxydeoxyguanosine, gamma-H2AX, and nitrotyrosine in tumors. More evident anti-inflammatory and cancer preventive activities of dietary gamma-TmT were demonstrated in mice treated with azoxymethane and dextran sulfate sodium. These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols, according to "Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols" by Yang CS, Lu G, Ju J, Li GX.(1)
2. Cancer prevention
The study of the cancer-preventive activities of tocopherols and tocotrienols, indicated that a gamma-tocopherol-rich mixture of tocopherols inhibits colon, prostate, mammary, and lung tumorigenesis in animal models, suggesting that this mixture may have a high potential for applications in the prevention of human cancer. In this review, we discuss biochemical properties of tocopherols, results of possible cancer-preventive effects in humans and animal models, and possible mechanisms involved in the inhibition of carcinogenesis. Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research, according to "Cancer-preventive activities of tocopherols and tocotrienols" by Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, Yang CS.(2)
3. Bone formation
In the investigation of the antioxidant and anti-inflammatory properties of Alpha- and gamma-tocopherol, the two predominant isomers of vitamin E and their effects on bone metabolism, found that gamma-tocopherol may uncouple bone turnover, resulting in more bone formation than resorption. Vitamin E supplements in the form of alpha-tocopherol suppress serum gamma-tocopherol levels and may have negative effects on bone formation. Further research is needed to investigate the potential anabolic effect of gamma-tocopherol from food sources on bone, according to "Effects of vitamin E on bone turnover markers among US postmenopausal women" by Hamidi MS, Corey PN, Cheung AM.(3)
4. Liver fibrosis
In the study of Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells, found that significant cell detachment was also observed in δ-tocopherol- and tocol-treated HSCs. Decreased protein expressions of α-smooth muscle actin and β1 integrin were observed in a dose-dependent manner. These results indicate that δ-tocopherol and tocol induce anoikis in activated HSCs, according to "Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells" by Yamaguchi N, Mezaki Y, Miura M, Imai K, Morii M, Hebiguchi T, Yoshikawa K.(4)
5. Antioxidant and Antidiabetic Activities
In the determination of the antioxidant and antidiabetic activities of proximate composition, amino acids, fatty acids, tocopherols, sterols, glucosinolate and phenolic content in extracts, found that all examined extracts were prominently rich in phenolics and glucosinates, and they showed potent antidiabetic and antihemolytic activity. The present study could be helpful in developing medicinal preparations for the treatment of diabetes and related symptoms, according to "Compositional Studies: Antioxidant and Antidiabetic Activities of Capparis decidua (Forsk.) Edgew" by Zia-Ul-Haq M, Cavar S, Qayum M, Imran I, de Feo V.(5)
6. Breast cancer
in the investigation of the breast cancer effect of vitamin E, consisting of eight different variants: α-, β-, γ-, and δ-tocopherols (saturated phytyl tail) and α-, β-, γ-, and δ-tocotrienols (unsaturated phytyl tail), indicated that γ-tocopherol, and more recently δ-tocopherol, have shown greater ability to reduce inflammation, cell proliferation, and tumor burden. Recent results have shown that γ-enriched mixed tocopherols inhibit the development of mammary hyperplasia and tumorigenesis in animal models, according to "Chemopreventive Activity of Vitamin E in Breast Cancer: A Focus on γ- and δ-Tocopherol" by Smolarek AK, Suh N.(6)
7. Colon cancer
In the investigation of the effects of both alpha and gamma-tocopherol on the expression of PPARgamma mRNA and protein in SW 480 colon cancer cell lines and measurement of the intracellular concentrations of vitamin E in SW 480 colon cancer cell lines, found that both alpha and gamma-tocopherol can upregulate the expression of PPARgamma which is considered an important molecular target for colon cancer chemoprevention, according to "Gamma (gamma) tocopherol upregulates peroxisome proliferator-activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines" by Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K.(7)
8. Antioxidant defense
in the study of salmon, a rich source of marine n-3 fatty acids, which may increase oxidative stress and, in turn, and its affect the antioxidant defense system in blood plasma and erythrocytes of pregnant women, found that besides, a concomitant increase in selenium and glutathione concentration, as well as glutathione peroxidase and reductase activities, were detected as the pregnancy progressed. However, tocopherols, retinol, β-carotene, and coenzyme Q(10) decreased in late pregnancy. Collectively, our findings lead to the hypothesis that increased farmed salmon intake may increase antioxidant defenses during pregnancy, according to "Does Consumption of Two Portions of Salmon Per Week Enhance the Antioxidant Defense System in Pregnant Women?" by García-Rodríguez CE, D Mesa M, Olza J, Vlachava M, Kremmyda LS, Diaper ND, Noakes PS, Miles EA, Ramírez-Tortosa MC, Liaset B, Frøyland L, Rossary A, Farges MC, Vasson MP, Aguilera CM, Helmersson-Karlqvist J, Godfrey KM, Calder PC, Basu S, Gil A.(8)
9. The antioxidant and anti-inflammatory activities
In the investigation of the antioxidant and anti-inflammatory actions of tocopherols in mice and determination of whether the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is involved in these activities, indicated that the antioxidant and anti-inflammatory activities of γ-TmT in the colon are mostly due to the direct action of tocopherols in trapping reactive oxygen and nitrogen species, independent of the antioxidant enzymes and anti-inflammatory proteins that are regulated by Nrf2; however, Nrf2 knockout appears to affect the serum levels of tocopherol metabolites, according to "The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice" by Li G, Lee MJ, Liu AB, Yang Z, Lin Y, Shih WJ, Yang CS.(9)
10. Cognitive effects
In the examination of the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopheryl quinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopheryl quinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people, found that compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD, according to "Tocopherols and tocotrienols plasma levels are associated with cognitive impairment" by Mangialasche F, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M, Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P; AddNeuroMed Consortium. (10)
11. Renal effects
In the examination of whether γ-tocotrienol (GT3) protects against mitochondrial dysfunction and renal proximal tubular cell (RPTC) injury caused by oxidants, showed that report demonstrating the protective effects of GT3 against RPTC injury by 1) decreasing the production of ROS, 2) improving mitochondrial respiration, coupling, ΔΨ(m), and F₀F₁-ATPase function, 3) maintaining ATP levels, and 4) preventing RPTC lysis. Our data suggest that GT3 is superior to AT in protecting RPTCs against oxidant injury and may prove therapeutically valuable for preventing renal injury associated with oxidative stress, according to "γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death" by Nowak G, Bakajsova D, Hayes C, Hauer-Jensen M, Compadre CM.(11)
12. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20716280
(2) http://www.ncbi.nlm.nih.gov/pubmed/19748925
(3) http://www.ncbi.nlm.nih.gov/pubmed/22308007
(4) http://www.ncbi.nlm.nih.gov/pubmed/22293208
(5) http://www.mdpi.com/1422-0067/12/12/8846/
(6) http://www.ncbi.nlm.nih.gov/pubmed/22254089
(7) http://www.ncbi.nlm.nih.gov/pubmed/14521714
(8) http://www.ncbi.nlm.nih.gov/pubmed/22229304
(9) http://www.ncbi.nlm.nih.gov/pubmed/22226829
(10) http://www.ncbi.nlm.nih.gov/pubmed/22192241
(11) http://www.ncbi.nlm.nih.gov/pubmed/22040679
Fennel, The Potent Food That Processes Cyto-protection and Antitumor Activity
Fennel may have a potential and positive effect that induces cytoprotection and antitumor activity against cancer expression, scientists suggested.
The results of fennel efficacy were reported by several respectable institutes including the National Cancer Institute and the National Institute of Health.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
In the study to evaluate the efficacy of fennel seed methanolic extract (FSME) for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector in Swiss albino mice through injection of FSME, 100 mg/kg intraperitoneally into mice bearing EAC before exposed to three 2-Gy doses of gamma irradiation, researchers found at after 30 days, the application exerted a strong effect at the C50 (mean standard deviation 50% inhibitory concentrations) at a dose of 50 μg/mL for the MCF7 breast cancer cell line and 48 μg/mL for the Hepg-2 liver cancer cell line.
The treatment group also displayed a decreased level of MDA and improved natural antioxidants produced by the tissues of the host compared to the elevation of MDA and significantly reduced levels of catalase and GSH contents.
These results suggested that fennel seed methanolic extract (FSME) inhibited the overproduction of ROS caused by ingestion of doses of gamma irradiation through its anioxidants and enhanced antioxidants production of the mice tissue via the ratio of ROS and Antioxidants.
In other words, application of the fennel extract may have a potential in
* Reduced oxidative stress and protected mouse cells from damage caused by reactive oxygen species.
* Improved natural antioxidants and the oxidative stability of fatty foods during storage.
* Exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation.
Further illustration of the effect of herbal medicine in treatment of cancers and examine the cytoprotective effects, researchers at the National Institute of Health conducted a comparison of five herbal supplements, designated FB, FM, PP, HF, and FBL101, which contain different combinations of various natural herbs such as licorice, black cohosh, Dong Quai, false unicorn and vitex berry root against mice bearing CWR22R and PC3 prostate cancer xenografts.
According to the results of experiment,
* All herbal medicine, FB, FM, PP, HF, and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81%, and 87%, respectively.
* In CWR22R tumors, applications of supplements exerted a similar effect in suppressing the cancer cells.
* All applications did not show inhibitory activity against levels of testosterone in compared to untreated mice. However, supplements PP and FBL101 exerted significantly reduced VEGF levels, a potent angiogenic factor with function in stimulated production of new blood vessels to ensure cell proliferation, in PC3 and CWR22R tumors.
* Intratumoral microvessel density was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.
Dr. Ng SS, the lead author said, "herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".
The above differentiation was supported by the Quaid-i-Azam University in the analysis of the antibacterial potential of some medicinal plants against multi-drug resistant (MDR) pathogens and anticancer effect against MCF-7 cell line.
According to the results of the report, the application of Ethanol extract of Foeniculum vulgare exhibited significant inhibition of cancer cells proliferation and induction of cancer cell apoptosis and reduction of growth of Klebsiella pneumonia, Serratia marcescens, and Methicillin-resistant S. aureus. Pseudomonas aeruginosa
Taken together, fennel and its extracts may be used as a functional food in the exertion of cytoprotection and antitumor activity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare) by Mohamad RH1, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM.(PubMed)
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD.(PubMed)
(3) Study of anticancer and antibacterial activities of Foeniculum vulgare, Justicia adhatoda and Urtica dioica as natural curatives by Batool R1, Salahuddin H1, Mahmood T1, Ismail M2.(PubMed)
The results of fennel efficacy were reported by several respectable institutes including the National Cancer Institute and the National Institute of Health.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
In the study to evaluate the efficacy of fennel seed methanolic extract (FSME) for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector in Swiss albino mice through injection of FSME, 100 mg/kg intraperitoneally into mice bearing EAC before exposed to three 2-Gy doses of gamma irradiation, researchers found at after 30 days, the application exerted a strong effect at the C50 (mean standard deviation 50% inhibitory concentrations) at a dose of 50 μg/mL for the MCF7 breast cancer cell line and 48 μg/mL for the Hepg-2 liver cancer cell line.
The treatment group also displayed a decreased level of MDA and improved natural antioxidants produced by the tissues of the host compared to the elevation of MDA and significantly reduced levels of catalase and GSH contents.
These results suggested that fennel seed methanolic extract (FSME) inhibited the overproduction of ROS caused by ingestion of doses of gamma irradiation through its anioxidants and enhanced antioxidants production of the mice tissue via the ratio of ROS and Antioxidants.
In other words, application of the fennel extract may have a potential in
* Reduced oxidative stress and protected mouse cells from damage caused by reactive oxygen species.
* Improved natural antioxidants and the oxidative stability of fatty foods during storage.
* Exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation.
Further illustration of the effect of herbal medicine in treatment of cancers and examine the cytoprotective effects, researchers at the National Institute of Health conducted a comparison of five herbal supplements, designated FB, FM, PP, HF, and FBL101, which contain different combinations of various natural herbs such as licorice, black cohosh, Dong Quai, false unicorn and vitex berry root against mice bearing CWR22R and PC3 prostate cancer xenografts.
According to the results of experiment,
* All herbal medicine, FB, FM, PP, HF, and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81%, and 87%, respectively.
* In CWR22R tumors, applications of supplements exerted a similar effect in suppressing the cancer cells.
* All applications did not show inhibitory activity against levels of testosterone in compared to untreated mice. However, supplements PP and FBL101 exerted significantly reduced VEGF levels, a potent angiogenic factor with function in stimulated production of new blood vessels to ensure cell proliferation, in PC3 and CWR22R tumors.
* Intratumoral microvessel density was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.
Dr. Ng SS, the lead author said, "herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".
The above differentiation was supported by the Quaid-i-Azam University in the analysis of the antibacterial potential of some medicinal plants against multi-drug resistant (MDR) pathogens and anticancer effect against MCF-7 cell line.
According to the results of the report, the application of Ethanol extract of Foeniculum vulgare exhibited significant inhibition of cancer cells proliferation and induction of cancer cell apoptosis and reduction of growth of Klebsiella pneumonia, Serratia marcescens, and Methicillin-resistant S. aureus. Pseudomonas aeruginosa
Taken together, fennel and its extracts may be used as a functional food in the exertion of cytoprotection and antitumor activity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare) by Mohamad RH1, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM.(PubMed)
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD.(PubMed)
(3) Study of anticancer and antibacterial activities of Foeniculum vulgare, Justicia adhatoda and Urtica dioica as natural curatives by Batool R1, Salahuddin H1, Mahmood T1, Ismail M2.(PubMed)
Monday, August 16, 2021
Ginger, The Best to Normal Your Blood Cholesterol With No Side Effects
Ginger may be considered a functional food for the prevention and treatment of hyperlipidemia without inducing side effects, some scientists found.
Hyperlipidemia is a condition of abnormally high blood cholesterol.
In other words, people with hyperlipidemia have an elevated ratio of low-density lipoprotein/ high-density lipoprotein.
The normal and healthy ratio of healthy blood cholesterol is lower than 4/1.
The most common causes of high blood cholesterol are an unhealthy diet with high saturated and trans fat, red meat and processed foods, and few in fruits and vegetables.
In fact low intake of high-density lipoproteins which have the unique function to trnasport the excess cholesterol back to the liver.
In other words, the presence of high-density lipoproteins reduces the bad blood cholesterol in the bloodstream, thus decreasing the forming of plaque accumulated in the arterial wall, the major risk of heart disease.
Some researchers suggested that genetic preposition and certain medical conditions such as diabetes mellitus, kidney disease, and hypothyroidism may also increase the risk of hyperlipidemia.
The most common types of high-density lipoproteins can be found in olive oil which has been found to lower the inflammatory impact of LDL cholesterol on the body, beans, and legumes, whole grains. ... high-fiber fruit, and deep-sea fatty fish.
Therefore, by topical 2 spoonfuls of olive oil to your lunch salad every day, you may kiss the hyper cholesterol goodbye after six months.
Why it takes so long? because olive oil is a food and fat, not Western single-ingredient medicine.
Dr. Cullinen K in the nutrition team at the Rhode Island Department of Health, said, "Olive oil consumption increases HDL-cholesterol levels, while decreasing LDL-cholesterol levels, LDL susceptibility to oxidation and lipid peroxidation".
And, "The reduction of cellular oxidative stress, thrombogenicity and the formation of atheroma plague can explain the preventive effects of olive oil on atherosclerosis development".
These results clearly supported the use of oiler oil for the treatment in patients with hyperlipidemia.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food for the treatment of abnormally high blood cholesterol with no side effects, researchers at the Tehran University of Medical Sciences assessed the effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial included 70 type 2 diabetic patients allocated randomly into the ginger group and control group.
The treatment group consumed 1600 mg ginger versus 1600 mg wheat flour consumed by the placebo daily for 12 weeks.
At the end of the trial, researchers showed that the ginger treatment group exerts a significantly reduced fasting plasma glucose, HbA1C, insulin resistance, HOMA, triglyceride, total cholesterol, CRP, and PGE₂, compared to placebo group.
However, there were no significant differences in HDL, LD, and TNFα between two groups.
These results clearly suggested ginger has a strong effect in improving all parameters associated with diabetic symptoms.
Dr. Arablou T in the final report said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients".
Other researchers in the concern of oxidative stress in the development and progression of diabetic nephropathy (DN)launched an investigation to examine the potential protective effect of ginger (Zingiber officinale) rhizome extract on hyperglycemia-induced oxidative stress, inflammation, and apoptosis.
Diabetes rats selected to the study were given 400 or 800 mg/kg/day Z. officinale extract for six weeks orally.
Treatment with Z. officinale not only improved all diabetic symptoms but also ameliorated hyperglycemia, hyperlipidemia and kidney function.
In addition, Z. officinale minimized the histological alterations in the kidney of diabetic rats
The evidence indicated Z. officinale extract significantly attenuated oxidative stress, inflammation and apoptosis, and enhanced antioxidant defenses in the diabetic kidney.
Taken all together, ginger may be considered a functional food for the prevention and treatment of abnormally high blood cholesterol with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) POSSIBLE HYPOCHOLESTEROLEMIC EFFECT OF GINGER AND ROSEMARY OILS IN RATS. by Eissa FA1, Choudhry H1,2,3, Abdulaal WH1,3, Baothman OA1, Zeyadi M1, Moselhy SS1,4,5,6, Zamzami MA1,2. (PubMed)
(3) Ginger alleviates hyperglycemia-induced oxidative stress, inflammation, and apoptosis and protects rats against diabetic nephropathy by Al Hroob AM1, Abukhalil MH2, Alghonmeen RD3, Mahmoud AM4. (PubMed)
(4) Olive oil in the treatment of hypercholesterolemia by Cullinen K. (PubMed)
Hyperlipidemia is a condition of abnormally high blood cholesterol.
In other words, people with hyperlipidemia have an elevated ratio of low-density lipoprotein/ high-density lipoprotein.
The normal and healthy ratio of healthy blood cholesterol is lower than 4/1.
The most common causes of high blood cholesterol are an unhealthy diet with high saturated and trans fat, red meat and processed foods, and few in fruits and vegetables.
In fact low intake of high-density lipoproteins which have the unique function to trnasport the excess cholesterol back to the liver.
In other words, the presence of high-density lipoproteins reduces the bad blood cholesterol in the bloodstream, thus decreasing the forming of plaque accumulated in the arterial wall, the major risk of heart disease.
Some researchers suggested that genetic preposition and certain medical conditions such as diabetes mellitus, kidney disease, and hypothyroidism may also increase the risk of hyperlipidemia.
The most common types of high-density lipoproteins can be found in olive oil which has been found to lower the inflammatory impact of LDL cholesterol on the body, beans, and legumes, whole grains. ... high-fiber fruit, and deep-sea fatty fish.
Therefore, by topical 2 spoonfuls of olive oil to your lunch salad every day, you may kiss the hyper cholesterol goodbye after six months.
Why it takes so long? because olive oil is a food and fat, not Western single-ingredient medicine.
Dr. Cullinen K in the nutrition team at the Rhode Island Department of Health, said, "Olive oil consumption increases HDL-cholesterol levels, while decreasing LDL-cholesterol levels, LDL susceptibility to oxidation and lipid peroxidation".
And, "The reduction of cellular oxidative stress, thrombogenicity and the formation of atheroma plague can explain the preventive effects of olive oil on atherosclerosis development".
These results clearly supported the use of oiler oil for the treatment in patients with hyperlipidemia.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food for the treatment of abnormally high blood cholesterol with no side effects, researchers at the Tehran University of Medical Sciences assessed the effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial included 70 type 2 diabetic patients allocated randomly into the ginger group and control group.
The treatment group consumed 1600 mg ginger versus 1600 mg wheat flour consumed by the placebo daily for 12 weeks.
At the end of the trial, researchers showed that the ginger treatment group exerts a significantly reduced fasting plasma glucose, HbA1C, insulin resistance, HOMA, triglyceride, total cholesterol, CRP, and PGE₂, compared to placebo group.
However, there were no significant differences in HDL, LD, and TNFα between two groups.
These results clearly suggested ginger has a strong effect in improving all parameters associated with diabetic symptoms.
Dr. Arablou T in the final report said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients".
Other researchers in the concern of oxidative stress in the development and progression of diabetic nephropathy (DN)launched an investigation to examine the potential protective effect of ginger (Zingiber officinale) rhizome extract on hyperglycemia-induced oxidative stress, inflammation, and apoptosis.
Diabetes rats selected to the study were given 400 or 800 mg/kg/day Z. officinale extract for six weeks orally.
Treatment with Z. officinale not only improved all diabetic symptoms but also ameliorated hyperglycemia, hyperlipidemia and kidney function.
In addition, Z. officinale minimized the histological alterations in the kidney of diabetic rats
The evidence indicated Z. officinale extract significantly attenuated oxidative stress, inflammation and apoptosis, and enhanced antioxidant defenses in the diabetic kidney.
Taken all together, ginger may be considered a functional food for the prevention and treatment of abnormally high blood cholesterol with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) POSSIBLE HYPOCHOLESTEROLEMIC EFFECT OF GINGER AND ROSEMARY OILS IN RATS. by Eissa FA1, Choudhry H1,2,3, Abdulaal WH1,3, Baothman OA1, Zeyadi M1, Moselhy SS1,4,5,6, Zamzami MA1,2. (PubMed)
(3) Ginger alleviates hyperglycemia-induced oxidative stress, inflammation, and apoptosis and protects rats against diabetic nephropathy by Al Hroob AM1, Abukhalil MH2, Alghonmeen RD3, Mahmoud AM4. (PubMed)
(4) Olive oil in the treatment of hypercholesterolemia by Cullinen K. (PubMed)
Friday, August 13, 2021
Ginger, the Potent Free radical Scavenging activities
Ginger may have a potential effect in reducing oxidative stress by inhibiting the overexpression of free radicals as scavengers, some studies suggested.
Free radical is an unstable molecule with an unpaired electron in the outer ring of the atom. In order for them to become stable, free radicals are actively donated or steal an electron from the stable molecules.
Once started, the chain of domino's effect cannot be stopped until the outer ring of the electron is paired or inhibited by the antioxidant.
Free radical scavengers are antioxidants that inhibit oxidation.
There are 2 types of antioxidants in the body including the antioxidant enzymes produced by the host and dietary sources of antioxidant intake by the host.
Oxidative stress is the expression of the imbalance of the levels of the free radicals and antioxidants in the body.
In other words, oxidative stress can either be caused by overexpression of free radicals or low levels of antioxidant enzymes.
A prolonged period of oxidative stress can damage the body tissue, alternated the immune function and cells DNA, leading to the etiology of many chronic health problems including cardiovascular and inflammatory disease, and cancer.
There are many causes of overexpression of free radicals, some researchers suggested that fried foods, alcohol, tobacco smoke, pesticides, air pollutants, and many more are contributed to the onset of the condition.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding the chemical constituents that constitute the free radical scavenger activity of ginger, a research team at the University of Mysore analyzed the chemical composition and antioxidant activity (in aqueous and solvent extracts) of Ginger root (Zingiber officinale).
During the experiment, application of ethanol, methanol, acetone, 80% methanol, and 80% ethanolic extracts to determine free radical scavenging activity, suggesting that the order of antioxidant activity by reducing power and free radical scavenging activity by DPPH was 80% methanolic > 80%ethanolic > methanolic > ethanolic > 30°C water >100°C water > acetonic extract.
These results suggested that ginger efficacy in the inhibition of the free radicals was not attributed to a single ingredient but all members of the antioxidant family.
In the investigation of the free radical scavenger activity of 4 essential oils of young and mature rhizomes, air-dried and steamed rhizomes, and seed rhizomes of Zingiber officinale Roscoe (ginger), researchers found
* All prepared ginger essential oils, showed a significant free radical scavenger property
* Essential oil from the seed and air-dried rhizomes demonstrated the highest anti-free radical activity compared to others preparation.
* Essential oil from the seed and air-dried rhizomes also are the better free radical scavenger agents, compared to ginger oleoresins obtained by ethanol and hypercritical carbon dioxide extraction and essential oils of 5 other plants in the family Zingiberaceae.
* [6]-shogaol, the bioactive compound isolated from the ginger was most active against filament formation and growth of C. Albicans, followed by citral and [6]-gingerol.
An additional examination also indicated that ginger oleoresin, and especially that obtained by ethanol extraction, with a high [6]-gingerol content exhibited potent scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radicals in comparison to essential oils of ginger and other Zingiberaceae plants.
In support of the above differentiation, researchers at the North China Coal Medical College, in the report of "[Scavenging effects of ginger on superoxide anion and hydroxyl radical]" wrote,
"Ginger can significantly scavenge O2-. in hypoxanthine-xanthine oxidase system and. OH in ultraviolet exposure of H2O2 system". and "The scavenging effects of ginger on O2-. and. OH may contribute to explaining some of the pharmacological mechanisms of this drug".
Taken altogether, ginger with the abundant bioactive compound may be considered a free radical scavenger functional food for preventing overexpression of free radical in the initiation of a chain reaction
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae by Takahashi M1, Inouye S, Abe S.(PubMed)
(2) [Scavenging effects of ginger on superoxide anion and hydroxyl radical].[Article in Chinese] by Cao ZF1, Chen ZG, Guo P, Zhang SM, Lian LX, Luo L, Hu WM. (PubMed)
(3) Chemical composition and antioxidant properties of ginger root (Zingiber officinale) (Research Gate)
Free radical is an unstable molecule with an unpaired electron in the outer ring of the atom. In order for them to become stable, free radicals are actively donated or steal an electron from the stable molecules.
Once started, the chain of domino's effect cannot be stopped until the outer ring of the electron is paired or inhibited by the antioxidant.
Free radical scavengers are antioxidants that inhibit oxidation.
There are 2 types of antioxidants in the body including the antioxidant enzymes produced by the host and dietary sources of antioxidant intake by the host.
Oxidative stress is the expression of the imbalance of the levels of the free radicals and antioxidants in the body.
In other words, oxidative stress can either be caused by overexpression of free radicals or low levels of antioxidant enzymes.
A prolonged period of oxidative stress can damage the body tissue, alternated the immune function and cells DNA, leading to the etiology of many chronic health problems including cardiovascular and inflammatory disease, and cancer.
There are many causes of overexpression of free radicals, some researchers suggested that fried foods, alcohol, tobacco smoke, pesticides, air pollutants, and many more are contributed to the onset of the condition.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding the chemical constituents that constitute the free radical scavenger activity of ginger, a research team at the University of Mysore analyzed the chemical composition and antioxidant activity (in aqueous and solvent extracts) of Ginger root (Zingiber officinale).
During the experiment, application of ethanol, methanol, acetone, 80% methanol, and 80% ethanolic extracts to determine free radical scavenging activity, suggesting that the order of antioxidant activity by reducing power and free radical scavenging activity by DPPH was 80% methanolic > 80%ethanolic > methanolic > ethanolic > 30°C water >100°C water > acetonic extract.
These results suggested that ginger efficacy in the inhibition of the free radicals was not attributed to a single ingredient but all members of the antioxidant family.
In the investigation of the free radical scavenger activity of 4 essential oils of young and mature rhizomes, air-dried and steamed rhizomes, and seed rhizomes of Zingiber officinale Roscoe (ginger), researchers found
* All prepared ginger essential oils, showed a significant free radical scavenger property
* Essential oil from the seed and air-dried rhizomes demonstrated the highest anti-free radical activity compared to others preparation.
* Essential oil from the seed and air-dried rhizomes also are the better free radical scavenger agents, compared to ginger oleoresins obtained by ethanol and hypercritical carbon dioxide extraction and essential oils of 5 other plants in the family Zingiberaceae.
* [6]-shogaol, the bioactive compound isolated from the ginger was most active against filament formation and growth of C. Albicans, followed by citral and [6]-gingerol.
An additional examination also indicated that ginger oleoresin, and especially that obtained by ethanol extraction, with a high [6]-gingerol content exhibited potent scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radicals in comparison to essential oils of ginger and other Zingiberaceae plants.
In support of the above differentiation, researchers at the North China Coal Medical College, in the report of "[Scavenging effects of ginger on superoxide anion and hydroxyl radical]" wrote,
"Ginger can significantly scavenge O2-. in hypoxanthine-xanthine oxidase system and. OH in ultraviolet exposure of H2O2 system". and "The scavenging effects of ginger on O2-. and. OH may contribute to explaining some of the pharmacological mechanisms of this drug".
Taken altogether, ginger with the abundant bioactive compound may be considered a free radical scavenger functional food for preventing overexpression of free radical in the initiation of a chain reaction
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae by Takahashi M1, Inouye S, Abe S.(PubMed)
(2) [Scavenging effects of ginger on superoxide anion and hydroxyl radical].[Article in Chinese] by Cao ZF1, Chen ZG, Guo P, Zhang SM, Lian LX, Luo L, Hu WM. (PubMed)
(3) Chemical composition and antioxidant properties of ginger root (Zingiber officinale) (Research Gate)
Saturday, August 7, 2021
Fennel and Its Extracts in Detoxed Body Toxins, According to PubMed Online Literature
Fennel may have a potential and positive effect in excess water and toxin from the body, some scientists suggested.
The result was reported on online medical literature conducted by some respectable institutes, including John Wiley & Sons, Ltd . and UFR Physiologie-Pharmacologie over different aspects via the number of mechanisms.
Diuresis is a medicine in the stimulation of increased production of urine.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In animal models, according to the John Wiley & Sons, Ltd. in the evaluation of the retoxic effect of ydroalcohol extracts of Foeniculum vulgare var dulce (D.C) root, application of the extract exerted significant activities in flushing out of excess water and toxin from the body through increased kidney function in secretion of the urine.
The result of these properties was observed by an increase in urine flow and urinary sodium excretion.
The efficacy in cleansing body was also found linearly in dose depending manner.
Continuously, in further examine the efficacy of fennel powder, extract, and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on a standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract and oil for 45 days, at the end of study, researchers found that
* Injected gentamicin group served as control exhibited strong nephrotoxicity manifested by increase levels of kidney function indicator, serum nitric oxide (NO), and kidney malondialdehyde (MDA) however, this group of rats also exerted a significant decrease in weight gain.
Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severed oxidative stress caused by an imbalanced ratio of ROS and antioxidants in the host.
* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improved level of urea and uric acid in comparison to control (+ve) and displayed an improvement of antioxidant enzymes as the increase of serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.
These results addressed the important antioxidant effect of fennel extracts. Applications not only inhibited the levels of free radical and theirs' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.
* Moreover, the group treated with fennel oil restore the normal values of kidney antioxidant enzymes compared with a normal group and other treatment groups.
Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account other co and confounders said, "fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats".
Clearly, fennel oil exhibited the greatest effect in stimulated kidney function in detox the body toxins through increased secretion of urine in comparison to another experimental group.
The results of this study clearly indicate that fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats. [Soheir Ahamed Al-Masri and Waffa, Sh. Ali. The Ameliorating
Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduced hypertension through Foeniculum increased water, sodium and potassium excretion in compared to non effect of Marrubium treated group.
Additionally, compared to Marrubium extract in reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.
Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.
Taken together, fennel and its extracts may be considered as a detox functional food in getting rid of body toxins through its diuretic activities.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)
The result was reported on online medical literature conducted by some respectable institutes, including John Wiley & Sons, Ltd . and UFR Physiologie-Pharmacologie over different aspects via the number of mechanisms.
Diuresis is a medicine in the stimulation of increased production of urine.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In animal models, according to the John Wiley & Sons, Ltd. in the evaluation of the retoxic effect of ydroalcohol extracts of Foeniculum vulgare var dulce (D.C) root, application of the extract exerted significant activities in flushing out of excess water and toxin from the body through increased kidney function in secretion of the urine.
The result of these properties was observed by an increase in urine flow and urinary sodium excretion.
The efficacy in cleansing body was also found linearly in dose depending manner.
Continuously, in further examine the efficacy of fennel powder, extract, and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on a standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract and oil for 45 days, at the end of study, researchers found that
* Injected gentamicin group served as control exhibited strong nephrotoxicity manifested by increase levels of kidney function indicator, serum nitric oxide (NO), and kidney malondialdehyde (MDA) however, this group of rats also exerted a significant decrease in weight gain.
Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severed oxidative stress caused by an imbalanced ratio of ROS and antioxidants in the host.
* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improved level of urea and uric acid in comparison to control (+ve) and displayed an improvement of antioxidant enzymes as the increase of serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.
These results addressed the important antioxidant effect of fennel extracts. Applications not only inhibited the levels of free radical and theirs' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.
* Moreover, the group treated with fennel oil restore the normal values of kidney antioxidant enzymes compared with a normal group and other treatment groups.
Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account other co and confounders said, "fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats".
Clearly, fennel oil exhibited the greatest effect in stimulated kidney function in detox the body toxins through increased secretion of urine in comparison to another experimental group.
The results of this study clearly indicate that fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats. [Soheir Ahamed Al-Masri and Waffa, Sh. Ali. The Ameliorating
Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduced hypertension through Foeniculum increased water, sodium and potassium excretion in compared to non effect of Marrubium treated group.
Additionally, compared to Marrubium extract in reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.
Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.
Taken together, fennel and its extracts may be considered as a detox functional food in getting rid of body toxins through its diuretic activities.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)
Monday, August 2, 2021
Ginger, Relieves Pain and Reduced Disability of Patients with Osteoarthritis
Ginger may have a potential and positive effect in ameliorating the symptoms of pain and complication of reduced quality of life in patients with osteoarthritis, some scientists suggested.
Osteoarthritis (OA) is a chronic condition of a type of joint disease characterized by the breaking down of joint cartilage and underlying bone due to the “wear and tear” of joints over time.
Some researchers suggested that OA is a degenerative disease characterized by “low-grade inflammation” in the cartilage and synovium, affecting the joint structure and progressive deterioration of cartilage.
According to the statistic from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% in men and 13% in women.
Epidemiological strongly suggested that obese and overweight which have a strong impact on the weight-bearing joints, the genetic preposition of a patient can make such patient more susceptible to the disease compared to others do not, people with a joint injury that did heal properly at the younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting or other movements and the increase in age are associated to the increased risk of the onset of the disease.
The most common symptoms of osteoarthritis are joint pain and stiffness.
Dr. Giuseppe Musumeci, the lead author in the study "Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression" suggested that besides the risk factors mentioned above, dietary factors also play an important role in the onset of the disease.
In the dietary aspect in the induction of OA, the research team wrote, "This diet (The Western diet) is mainly constituted by preservative and harmful substances, such as animal fat and glucose excessive concentration and lack of nutritional factors, such as vitamins and nutrient minerals essential for our body. Moreover, the bad dietary habits may predispose people to obesity, which is responsible for both metabolic destroying processes affecting the cartilage and overload of the joints, especially hips and knees".
And, " quantity and quality of nutrient intake. Low intake of vitamin D and vitamin C is a possible risk factor for knee OA, while certain food groups, such as milk and dairy products, meat and poultry are beneficial for knee OA. Thus we could affirm that nutritional imbalance, combined with endocrine abnormalities, may be involved in the pathogenesis of OA".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reaffirm the traditional use of ginger for the treatment of osteoarthritis, a joint review led by the Copenhagen University Hospital, Bispebjerg, and Frederiksberg were conducted to assess the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA).
The study was carried out by searching the randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years satisfied the predetermined guidelines and criteria, including the outcomes of the reduction in pain and disability.
Out of 122 retrieved references, 117 were discarded, only 5 five trials (593 patients) were selected for meta-analyses.
All 5 remained studies suggested that ginger intake scored a statistically significant pain reduction.
Furthermore, application of ginger in subjects with osteoarthritis demonstrates a statistically significant reduction in disability compared to control.
However, according to the returned questionnaires from the participants, researchers surprisingly found that patients given ginger are more than twice as likely to discontinue treatment compared to placebo.
Dr. Mozaffari-Khosravi H, the lead author, launched a joint study to determine the ginger powder effects in relieving pain and inflammation in patients with osteoarthritis.
120 participants selected for the randomized double-blind placebo-controlled 3-month clinical trial for knee osteoarthritis were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG).
Ginger selected group was given capsules containing 500 mg of ginger powder, while the PG group was given capsules filled with 500 mg starch.
At the baseline, proinflammatory cytokine concentrations did not differ by group, observed by the participant's blood sample.
After 3 months, GG showed a significant reduction of cytokines compared to the PG.
In the final report, the research team wrote, "ginger supplementation may have promising benefits for knee osteoarthritis".
These results reconfirming the use of ginger for the treatment of osteoarthritis in traditional medicine with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(2) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(3) Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression by Giuseppe Musumeci,1,* Flavia Concetta Aiello,1 Marta Anna Szychlinska,1Michelino Di Rosa,2 Paola Castrogiovanni,1 and Ali Mobasheri. (PubMed)
Osteoarthritis (OA) is a chronic condition of a type of joint disease characterized by the breaking down of joint cartilage and underlying bone due to the “wear and tear” of joints over time.
Some researchers suggested that OA is a degenerative disease characterized by “low-grade inflammation” in the cartilage and synovium, affecting the joint structure and progressive deterioration of cartilage.
According to the statistic from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% in men and 13% in women.
Epidemiological strongly suggested that obese and overweight which have a strong impact on the weight-bearing joints, the genetic preposition of a patient can make such patient more susceptible to the disease compared to others do not, people with a joint injury that did heal properly at the younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting or other movements and the increase in age are associated to the increased risk of the onset of the disease.
The most common symptoms of osteoarthritis are joint pain and stiffness.
Dr. Giuseppe Musumeci, the lead author in the study "Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression" suggested that besides the risk factors mentioned above, dietary factors also play an important role in the onset of the disease.
In the dietary aspect in the induction of OA, the research team wrote, "This diet (The Western diet) is mainly constituted by preservative and harmful substances, such as animal fat and glucose excessive concentration and lack of nutritional factors, such as vitamins and nutrient minerals essential for our body. Moreover, the bad dietary habits may predispose people to obesity, which is responsible for both metabolic destroying processes affecting the cartilage and overload of the joints, especially hips and knees".
And, " quantity and quality of nutrient intake. Low intake of vitamin D and vitamin C is a possible risk factor for knee OA, while certain food groups, such as milk and dairy products, meat and poultry are beneficial for knee OA. Thus we could affirm that nutritional imbalance, combined with endocrine abnormalities, may be involved in the pathogenesis of OA".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reaffirm the traditional use of ginger for the treatment of osteoarthritis, a joint review led by the Copenhagen University Hospital, Bispebjerg, and Frederiksberg were conducted to assess the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA).
The study was carried out by searching the randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years satisfied the predetermined guidelines and criteria, including the outcomes of the reduction in pain and disability.
Out of 122 retrieved references, 117 were discarded, only 5 five trials (593 patients) were selected for meta-analyses.
All 5 remained studies suggested that ginger intake scored a statistically significant pain reduction.
Furthermore, application of ginger in subjects with osteoarthritis demonstrates a statistically significant reduction in disability compared to control.
However, according to the returned questionnaires from the participants, researchers surprisingly found that patients given ginger are more than twice as likely to discontinue treatment compared to placebo.
Dr. Mozaffari-Khosravi H, the lead author, launched a joint study to determine the ginger powder effects in relieving pain and inflammation in patients with osteoarthritis.
120 participants selected for the randomized double-blind placebo-controlled 3-month clinical trial for knee osteoarthritis were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG).
Ginger selected group was given capsules containing 500 mg of ginger powder, while the PG group was given capsules filled with 500 mg starch.
At the baseline, proinflammatory cytokine concentrations did not differ by group, observed by the participant's blood sample.
After 3 months, GG showed a significant reduction of cytokines compared to the PG.
In the final report, the research team wrote, "ginger supplementation may have promising benefits for knee osteoarthritis".
These results reconfirming the use of ginger for the treatment of osteoarthritis in traditional medicine with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(2) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(3) Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression by Giuseppe Musumeci,1,* Flavia Concetta Aiello,1 Marta Anna Szychlinska,1Michelino Di Rosa,2 Paola Castrogiovanni,1 and Ali Mobasheri. (PubMed)
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