Herbal Turmeric Inhibits Parameters Associated with β-thalassemia

Anemia is a health condition in which our body do not have enough red blood cells or less than the normal quantity of hemoglobin in the blood that carries the function of delivering oxygen and nutrient to the tissues.


Patients with Beta-thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.


Beta thalassemia can be classified into
* Thalassemia minor, the mild case of anemia. is the most common anemia in people of Mediterranean descent. The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the loss of red blood cells.

* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in heart and other organs, resulting in heart failure.


Most common symptoms of beta thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.


If you have experienced persistently the aforementioned symptoms, please make sure that you check with your doctor for preventive measures.


Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.


The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural treatment for anemia, researchers examined the effects of curcumin, the active polyphenol in turmeric, on iron overload, hepcidin level, and liver function in β-thalassemia major patients.

The double-blind randomized controlled clinical trial was conducted on 68 β-thalassemia major patients, randomly divided into 2 groups to receive either 500 mg curcumin capsules (total: 1,000 mg) twice daily or a placebo for 12 weeks.

Based on the observation of the tested assays, the curcumin group showed a significant decrease in levels of nontransferrin bound iron (NTBI), aminotransferase (ALT) and Aspartate aminotransferase (AST) compared to the placebo group.

In other words, turmeric protects the integrity of the red blood by reducing the cellular oxidative stress and inhibiting the iron toxicity in the β-thalassemia major patients without affecting the levels of hepcidin and other variables.


Based on the results, researchers wrote, " Curcumin administration alleviated the iron burden and liver dysfunction by reducing NTBI, ALT, and AST levels in patients with β-thalassemia major".

Additionally, according to the evaluation of the Mahidol University on 10 β-thalassemia/Hb E patients treated with 500 mg curcuminoids daily for 12 months, injection of the supplement showed significantly decreased intensity in thalassemic plasma, compared to those of normal subjects, including increased levels of plasma levels of proteins associated with the condition and reduced levels of oxidative damage.

More precisely, serum non-transferrin bound iron associated with iron overload, platelet factor-3-like activity, oxidative stress parameters, and antioxidant enzymes were also improved after curcuminoids treatment.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of β-thalassemia, pending to the confirmation of the larger sample size and multicenter human study.



Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial by Mohammadi E1, Tamaddoni A2, Qujeq D3, Nasseri E4, Zayeri F5, Zand H6, Gholami M7, Mir SM. (PubMed)
(2) Role of curcuminoids in ameliorating oxidative modification in β-thalassemia/Hb E plasma proteome by Weeraphan C1, Srisomsap C, Chokchaichamnankit D, Subhasitanont P, Hatairaktham S, Charoensakdi R, Panichkul N, Siritanaratkul N, Fucharoen S, Svasti J, Kalpravidh RW. (PubMed)

Herbal Fennel In Reduced Symptoms and Treatment of Estrogenic Deficiency Related Diseases

Fennel may have a potential effect in increased plant base estrogenic levels in reduced risk of estrogen-related diseases, some scientists suggested.

Estrogen is a primary female sex hormone, responsible for the development and regulation of the female reproductive system and secondary sex characteristics.


Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In the evaluation of the fennel estrogenic effect in inhibiting the increased ectopic uterine motility in facilitated symptoms including pain in primary dysmenorrhea, researchers found that compared to non-steroidal anti-inflammatory drugs (NSAIDs) in the induction of severe adverse effects used for treatment in long-term therapy, application of fennel essential oil (FEO) of LD(50, 1326 mg/kg) in a rat model, exerted a therapeutic effect in reduced expression of prostaglandin E(2) (PGE(2)) in induced muscle contraction.


Further analysis suggested that fennel essential oil reduced the intensity of oxytocin and PGE(2) induced uterine muscle contractions significantly (25 and 50 microg/ml for oxytocin and 10 and 20 microg/ml PGE(2), respectively without inducing mortality in tested subjects.


Abnormal production of prostaglandins E2 was found to associate to the intensity of symptoms of primary dysmenorrhea, including vomiting, fever, diarrhea, and excessive uterine contraction.



According to the P. G. Institute of Basic Medical Sciences, acetone extract isolated from Foeniculum vulgare Mill., seeds at different dose levels (50/ug, 150/ug and 250/ug/100gm body wt.) exerted a potential and positive estrogenic activity in increased nucleic acids and protein concentration and organ weights, particularly in the medium and high doses.

The above differentiation were supported by the study of "Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats" conducted by Dr. Malini T and colleagues.


According to the results, fennel estrogenic effect in oral administration of acetone extract of Foeniculum vulgare (fennel) seeds for 15 days in male rats, exerted a significant malformation of the male reproductive tract including decreased in testes through inhibited Leydig cell production of testosterone and disrupted fluid reabsorption in the efferent ductules via the ERα and vas deferens in transported sperm from the testicle to the urethra.

Moreover, the application of the extract also demonstrated an increased volume of seminal vesicles and prostate gland and decreased activities of acid and alkaline phosphatase in all these regions, including bones, intestines, pancreas, and kidneys.

In female rats, ingestion of acetone extract for 10 days showed a strong effect in the expression of estrogenic effect through the observation by vaginal cornification, the test of appearance of cornified epithelial cells in a vaginal smear for confirmation of the presence of high levels of estrogen.

The application also catalyzed the imbalanced production of sex hormones in the female estrus cycle.


At moderate doses, the seeds caused an increase in the weight of mammary glands by overexpression of estrogen circulation in precipitated a negative effect in regulated systemic mammogenic factors (prolactin, growth hormone), and directed influence of the mammary tissue, such as stromal components and epithelial cells.
At higher doses, fennel seeds increased the weight of the oviduct, endometrium, myometrium, cervix, and vagina.



Taken together, fennel may be considered a functional food for reduced symptoms of estrogen deficiency syndrome and combined with the standard medicine for the treatment of estrogenic-related diseases.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats by Malini T, Vanithakumari G, Megala N, Anusya S, Devi K, Elango V.(PubMed)
(2) Primary dysmenorrhoea: the importance of both prostaglandins E2 and F2 alpha by Lumsden MA, Kelly RW, Baird DT.(PubMed)
(2) Effect of foeniculum vulgare seed extract on mammary glands and oviducts of ovariectomised rats by Devi K1, Vanithakumari G, Anusya S, Mekala N, Malini T, Elango V.(PubMed)
(3) Fennel and anise as estrogenic agents by Albert-Puleo M.(PubMed)
(4) The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study by Ostad SN1, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H.(PubMed)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)

Herbal Arctostaphylos uva-ursi Effects on Endometrial Cancer

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe. The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.

The endometrium is the inner lining of the mammalian uterus and is very susceptible to hormone change, particularly during the menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition in which the cells of the endometrial lining of the uterus have growth uncontrollable or become cancerous as a result of the alternation of cells' DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

The Ingredients It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.

The benefits
Ursolic acid, a pentacyclic triterpene acid, extracted from bearberry is found to be effective in inhibiting the growth of endometrial cancer cell HEC108 line, in a dose- and time-dependent manner. As exposure to Ursolic acid decreased the anti-apoptotic Bcl-2 protein levels (member of the Bcl-2 family of regulator proteins that regulate cell death) but increased Bax expression (upregulated by the tumor suppressor protein p53,) through a mitochondrial pathway, that induced apoptosis of endometrial cancer HEC108 line. Other in the study of the same but within endometrial cancer SNG-II cells, ursolic acid strongly inhibited the growth of SNG-II cells in a dose- and time-dependent manner. The induced apoptotic processes in the endometrial cancer SNG-II cells is also involved mitochondrial pathways and Bcl-2 family proteins.

The Side effect
1. Overdoses may cause gastrointestinal discomfort, including cause nausea, vomiting, etc., fever, chills, severe back pain, ringing in the ears, etc.
2. The herb may interact with other medicine, including diuretics
3. Do not use the herb in newborns, children, or if you are pregnant or breastfeeding without approval from the related field specialist.
4. Etc.


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References
(1) Molecular mechanism of ursolic acid-induced apoptosis in poorly differentiated endometrial cancer HEC108 cells by Achiwa Y, Hasegawa K, Udagawa Y.(PubMed)
(2) Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells by Achiwa Y, Hasegawa K, Komiya T, Udagawa Y.(PubMed)

Chaste tree berry, The Antinociceptive Functional Food

A recent study suggested that essential oil isolated from Chaste tree berry may have a potential effect in reduced neuro-pain through antinociceptive function in tested subjects.

The antinociceptive effect is the activity of reduced pain through interference with information transmitted and received by brain neurons.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.

In the study of three behavioral models of nociception in adult male Wistar rats conducted by the University of Tabriz, the topical essential oil extracted from Vitexagnus-castus (EOVAC) was applied to animals expressed a reduced pain response in tail immersion tests, inhibited the acetic acid-induced writhing response with little adverse effects.

Dr. Khalilzadeh E, the lead author said, " major components of the EOVAC were α-pinene (14.83%), limonene (10.29%), β-caryophyllene (6.9%), sabinene (5.27%), and β-farnesene (5.9%), (may have direct influence to the) endogenous opioidergic system, as well as muscarinergic receptors of the cholinergic system, may be involved in the antinociceptive activity of Vitex agnus-castus essential oil in these models of pain in rats".


Interestingly, the extract of herbal medicine also displayed a strong effect against chronic inflammation in induced pain.

The joint study led by the Federal University of Santa Maria suggested that crude extract caused antinociceptive/antidepressant-like effects in the CFA-induced chronic inflammation model incomparable to naloxone, without altered inflammatory parameters at doses of 10mg/kg,


This result indicated that The VmE extract demonstrated pain relief by inducing opioid-dependent antinociception and antidepressant-like effects, without anti-inflammatory activity.


Furthermore, in the investigated petroleum ether fraction (PEF) from the aqueous ethanol extract of Chaste tree berry in several nociceptive mouse models, mouses treated with the fraction produced significant dose-related inhibitions on chemical nociception incomparable to Naloxone (1 mg/kg BW subcutaneously), a non-selected opioid receptor antagonist.

In the xylene-induced ear edema test, the fraction also exerted strong analgesic effects partially mediated by its anti-inflammatory activity.

Taking together, Chaste tree berry may have a therapeutic potential to be used as an antinociceptive functional food in reduced pain by blocking the information transfer by neurotransmitters.


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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil by Khalilzadeh E, Vafaei Saiah G, Hasannejad H, Ghaderi A, Ghaderi S, Hamidian G, Mahmoudi R, Eshgi D, Zangisheh M.(PubMed)
(2) Antinociceptive and antidepressant-like effects of the crude extract of Vitexmegapotamica in rats by Hamann FR1, Zago AM2, Rossato MF3, Beck VR4, Mello CF4, de Brum TF5, de Carvalho LM6, Faccin H6, Oliveira SM7, Rubin MA8(PubMed)
(3) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)

Healthy Food Fennel, a Natural Anti Fever Functional Food

Scientists may have found food and plant processes the antipyretic activity comparable to those of acetaminophen in patients with fever, some studies suggested.

Fever is a natural reaction caused by the production of pro-inflammatory cytokines in the immune system in protecting our body from damage and injury against foreign pathogens during the acute phase of infection.

According to medical literature, a person is not considered to have a significant fever until the temperature is above 100.4 F (38.0 C).



Although fever is a common syndrome, however, if you or your kid are experiencing fever accompanied by symptoms of a severe headache, unusual skin rash, sensitivity to bright light, persistent stiff neck and pain, mental confusion, particularly persistent vomiting, and difficulty breathing or chest pain, you or your kid should go to the hospital right the way.

Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The plant and food have been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...

In the study to evaluate the antipyretic effect of the aqueous extract of an herbal coded formulation containing an equal amount of Salix alba, Emblica Officinalis, Glycyrrhiza glabra, Adhatoda vasica, Viola odorata, in a yeast induced pyrexia model in rabbits, researchers found that after recording the results immediately before the administration of the extractor paracetamol and again at 1 hour, application of the extract at 240mg/kg dose significant reduces elevated temperature as compared with that of standard drug paracetamol (150mg/kg).

Fennel extract applied alone showed antipyretic activity against hyperpyrexia in mice, induced by S.C. administration of 2 mL/100 g of a 20% aqueous suspension of brewer's yeast.

As an antipyretic agent, ethanolic extract of F. vulgare fruit showed a moderate antipyretic activity that was statistically significant after 30 and 90 min.

These results showed that herbal coded medicine at a dose of 240mg/kg and fennel extract have marked an antipyretic activity in animal models and this was strongly supported by the ethnopharmacological uses of medicinal plants.

Furthermore, in the examine the hepatotoxicity induced by acetaminophen caused by the excessive production of N-acetyl-para-benzoquinone imine (NAPQI) in the induction of symptoms such as fever due to inflammation, researchers showed that the application of trans anethole, an aromatic compounds isolated from fennel exerted a significant effect in the inhibited pro-inflammatory mediators such as prostaglandin (PGE2), cytokines (TNF, IL-1) and nitric oxide (NO)thus decreasing the risk of fever caused by an overreaction of the immune system.

Application of AN at doses of 125 and 250mg/kg once a day for seven days prevented the changes caused by the APAP overdose.


Additionally, researchers also discovered, that AN infection prevents the overexpression of proinflammatory mediators such as NO, TNF, IL-1α, MIP-1α, and MCP-1 and induced the up-regulation of anti-inflammatory cytokines (IL-4 and IL-10), thus reducing the onset of fever.

Taken all together, there is no doubt that fennel may be considered a functional food for the treatment of inflammatory induced fever.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Antipyretic potential of herbal coded formulation (Pyrexol) by Khan MS1, Hamid A2, Akram M3, Mustafa SB3, Sami A1, Shah SMA4, Usmanghani K(PubMed)
(3) Acetaminophen-induced hepatotoxicity: Preventive effect of trans anethole by da Rocha BA1, Ritter AM2, Ames FQ3, Gonçalves OH4, Leimann FV5, Bracht L6, Natali MR7, Cuman RK8, Bersani-Amado CA(PubMed)

Chaste Tree Berry, The Whole Herb Medicine for Prevention and Treatment of Cataract

A recent study suggested that Chaste Tree Berry may be used to modulate the risk and treatment of selenite-induced cataractogenesis.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.

A cataract is a condition of blur vision caused by the clouding of the lens in the eye.

According to the University of Kerala, flavonoids found in the herbal plant exerted a cataract protective effect in reduced damage to the lenticular membrane and abnormal fiber structure in patients with cataracts viewed through electron microscopy.



Furthermore, the study also found that Chaste tree berry also expresses a significant improvement in chaperone property of α-crystallin and soluble protein levels in two-dimensional-polyacrylamide gel electrophoresis (2D-PAGE) and immunoblot analysis.


Dr. Rooban BN, the lead author said, " FVN modulated selenite induced cataractogenesis in rat pups by preventing loss of chaperone property, various changes in lens proteins, and lens structure, further strengthening its protective role".

Some researchers suggested that the efficacy of chaste tree berry in reduced risk and treatment of cataracts may be a result of phytochemical antioxidants activity in scavenging free radicals cause of the disease, such as oxidative stress, loss of calcium homeostasis, calpain activation, and protein insolubilization are found to associate to cataract patients.

More importantly, a study of eight-day-old Sprague-Dawley rat pups was divided into four groups: Control (G I), Sodium selenite-induced (G II), Sodium selenite+quercetin treated (G III), Sodium selenite+flavonoids from Vitex negundo (FVN) (G IV), group fed with sodium selenite+flavonoids showed normal levels of expression of the lens of water-soluble proteins in compared to other groups.


In fact, fed treated with FVN showed to exhibit the antioxidant effects in modulating biochemical parameters against selenite-induced cataracts, the University of Kerala insisted.

In support of the above differentiation, the Sprague-Dawley rat pups of 8 days old were divided into control (G I), selenite induced (G II), and selenite + V. negundo treated (G III) with cataract induced by the single subcutaneous injection of sodium selenite (4 mg/kg body weight) on the tenth day and V. negundo (2.5 mg/Kg body weight) administered intraperitoneally from eighth to 15th-day study, group III showed to exert reduced activities of superoxide dismutase, catalase, lower level of reactive oxygen species, Ca(2+), and thiobarbituric acid reactive substance significantly.


Taking together, Chaste tree berry may process of therapeutic potential used for the prevention and treatment of cataracts with mild adverse effects.

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Sources
(1) Analysis on the alterations of lens proteins by Vitex negundo in selenite cataract models by Rooban BN1, Sasikala V, Sahasranamam V, Abraham A.(PubMed)
(2) Vitex negundo attenuates calpain activation and cataractogenesis in selenite models by Rooban BN1, Lija Y, Biju PG, Sasikala V, Sahasranamam V, Abraham A.(PubMed)

Fennel Causes the Apoptosis of Cancer Cells, Scientists Find

Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.

Cell death is a natural process to warrant the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.


However, some microorganisms are found to process the activity in triggering cell death for their own survival.

Apoptosis, or programmed cell death, is a function of the immune system that evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection


Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.


Some herbal medicine such as fennel was shown to induce the function of overexpression of levels of free radical in initiating a cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.


Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

Herbal medicine has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle and relieve PMS,...

In the study to investigate several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukemia, J-45.01—human acute T cell leukemia, EOL—human eosinophilic leukaemia, HL-60—human Caucasian promyelocytic leukemia, 1301—human T cell leukemia lymphoblast, C-8166—human T cell leukemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. Vulgare shows the highest mortality in Trypan blue test for J45 cell line with 4% of viable cells and a C8166 cell line with 100% of mortality.


* The extract also shows the highest viability in other cell lines, including the HL60 with 60% EOLwith 48%, and ML1 with 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.

Furthermore, the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.

Application of fennel showed to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.


Fennel induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI-assay.


More importantly, the application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane and increased levels of caspase-9 & caspase-3, and DNA fragmentation in the promotion of MCF-7 cells death.experiment


Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".

Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.

* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.


Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.

Taken all together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for the treatment of cancers


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)