Herbal Bilberry, the Potential Treatment for Retinitis Pigmentosa, Researchers Say

Retinitis pigmentosa is a genetic condition characterized by the breakdown and gradual loss of cells in the retina.

The retina is the light-sensitive tissue lining the back of the eye. The function of the retina is to convert the light received into neural signals before sending them to the brain for visual recognition.
Most cases of retinitis pigmentosa are diagnosed during the teenage years and at birth. Some patients who carry the genetic preposition may develop the disease in later years.

The later diagnosed case is usually mild with slow progression compared to those presented in the teen years and at birth.

Most common symptoms of patients with retinitis pigmentosa are difficulty seeing at night and a loss of side (peripheral) vision. However, at the disease progress into the later stage, most patients also experience tunnel vision.

Conventionally, the treatment of retinitis pigmentosa is totally depending on the condition. The aim of treatment is to slow the vision loss and improve the patient quality of life.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of retinitis pigmentosa with not side effects examined the effects of Bilberry (Vaccinium myrtillus L.) and lingonberry (Vacciniumvitis-idaea) containing high amounts of polyphenols (anthocyanins, resveratrol, and proanthocyanidins) against blue light a high-energy or short-wavelength visible light-induced retinal diseases such as age-related macular degeneration and retinitis pigmentosa.

According to the results from the cultured murine photoreceptor (661 W) cells exposed to blue LED light following treatment with B-ext, L-ext, or their constituents (cyanidin, delphinidin, malvidin, trans-resveratrol, and procyanidin B2), B-ext, L-ext, NAC, and their active components improved the viability of 661 W cells against the blue light damage.

The efficacy was found to be attributed to the injection of tested compounds in inhibiting the generation of intracellular ROS induced by the blue LED light irradiation.

Furthermore, B-ext and L-d with also protected the cells integrity against the activation of proteins by stimuli associated with the production of production of proinflammatory cytokines.

Moreover, B-ext, L-ext, and NAC inhibited proteins involved in cell death and autophagy against cells damaged by blue light.

Dr. Ogawa K the lead scientist said, "These findings suggest that B-ext and L-ext containing high amounts of polyphenols exert protective effects against blue LED light-induced retinal photoreceptor cell damage mainly through inhibition of ROS production and activation of pro-apoptotic proteins".

In a murine model of photo-stressed retina, researchers examined the bilberry extract through a stomach tube in Balb/c mice (750 mg/kg body weight) light-induced visual function impairment.

According to the tested assays, bilberry extract suppressed photo-induced apoptosis in the photoreceptor cell layer and shortening of the outer segments of rod and cone photoreceptors.


Bilberry extracts also reduced the levels of photo-induced reactive oxygen species (ROS), oxidative and endoplasmic reticulum (ER) stress markers observed by the analysis.

In other words, bilberry inhibited the ER stress in the retina, and at least in part, in Müller glial cells.

Based on the findings, researchers suggested, "bilberry extract attenuates photo-induced apoptosis and visual dysfunction most likely, and at least in part, through ROS reduction, and subsequent ER stress attenuation in the retina".

Taken altogether, bilberry processed abundantly bioactive compounds may be considered a function remedy for the prevention and treatment of age-related macular degeneration and retinitis pigmentosa, pending the validation of larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro by Ogawa K, Kuse Y, Tsuruma K, Kobayashi S, Shimazawa M, Hara H1. (PubMed)
(2) Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina by Osada H1, Okamoto T1,2, Kawashima H1,2, Toda E1, Miyake S1,3, Nagai N1,2, Kobayashi S3, Tsubota K2, Ozawa Y. (PubMed)

Herbal Arctostaphylos uva-ursi, the Potential Anti Gastric/ Stomach Cancer Remedy

Scientists may have found a herbal remedy for the prevention and treatment of gastric cancer with no side effects, according to studies.

Gastric cancer or stomach cancer is a condition characterized by the abnormal growth of cells in the stomach tissue.

Most cases of gastric cancer start in the cells on the surface of the inner lining of the stomach tissue.

At stage 0, due to the gastric cancer cells being restricted or completely contained within the innermost layer of the lining, patients may not experience any symptoms.

However, at the later stage, the cancer cells can travel a distance away from the stomach to infect other tissue and organ, leading to secondary metastasis. If the tumor grows large enough, it may suppress the nearby blood vessels and nerve cells, causing blood to leak into the stomach and localized severe pain.

Besides common symptoms of cancers, patients with gastric cancer also experience some specific symptoms such as persistent abdominal (belly) pain., vague discomfort in the abdomen, a sense of fullness in the upper abdomen after eating a small meal, and heartburn or indigestion.

If you are having some of the above symptoms, please check with your doctor to rule out gastric cancer possibility.

Although there are many risk factors involved in the onset of the disease, such as family history, Helicobacter pylori infection, smoking, genetic preposition, certain stomach conditions, previous stomach surgery and type A blood, some researchers suggested that the most common cause of gastric cancer in the Western world is the Western diet-related disease.

Dr. Bertuccio P, the lead scientist at the Istituto di Ricerche Farmacologiche Mario Negri, in the concern of diet pattern in the risk of gastric cancer wrote, " An unfavorable role on GC emerged for the 'Western/unhealthy' dietary pattern, with an OR of 1.51 (95% CI: 1.21-1.89)" and "A favorable role on GC emerged for the 'Prudent/healthy', with an odds ratio (OR) of 0.75 [95% confidence interval (CI): 0.63-0.90], for the highest versus the lowest category".

The results strongly indicated the risk of gastric cancer is substantially higher in the Western diet group compared to the lower risk of a healthy diet.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb plant has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.

The plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.

With an aim to find a natural ingredient or whole food for the treatment of gastric cancer, researchers at the Shanghai University of Traditional Chinese Medicine examined the effects of ursolic acid isolated from bearberry (Arctostaphylos uva-ursi) against the pathogenesis of gastric cancer characterized by excessive proliferation, abnormal differentiation, and reduced apoptosis.

Ursolic acid, extracted from the traditional Chinese medicine bearberry, inhibited gastric cancer cell proliferation and induced apoptosis.

Further assessment of anti-gastric cancer, researchers discovered that ursolic acid exhibited apoptotic activity through cancer cell degradation observed in the gastric cancer BGC-823 cells.


In other words, efficacy is associated with a translocation of cofilin-1 protein that activates the function of cytochrome c in programmed cell death from the mitochondria to the cytoplasm.

These results suggested that ursolic acid activated the function of proteins (the caspase cascade) associated with the cell death and apoptotic pathway.


Where Mitochondria are the major organelles involved in the biochemical execution of apoptosis


Dr. the lead scientist, after taking into account co and confounders said, "mitochondrial translocation of cofilin-1 might play a crucial role in the promotion of apoptosis and might be a key target for future treatment of human gastric cancer".


Taken altogether, Bearberry (herbal Arctostaphylos uva-ursi) processed a major compound of ursolic acid may be considered a functional remedy for the prevention and combined with other primary medicine for the treatment of gastric cancer, pending the confirmation of large sample size and multicenter human study.


However, intake of ursolic acid as a supplement should be taken with extreme care to prevent overdoses and acute liver toxicity.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid by Tang Q, Ji Q, Tang Y, Chen T, Pan G, Hu S, Bao Y, Peng W, Yin P.(PubMed)
(2) Dietary patterns and gastric cancer risk: a systematic review and meta-analysis by Bertuccio P1, Rosato V, Andreano A, Ferraroni M, Decarli A, Edefonti V, La Vecchia C. (PubMed)

Herbal Ashwagandha Processes Lowering Cholesterol Property

Cholesterol produced by the liver plays an essential role in a moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls, and aiding the digestive system in absorbing nutrients and fluids.

Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.

Blood cholesterol can be classified into
* The high-density lipoprotein also known as good cholesterol processes a function to return cholesterol to the liver.

* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in a moderate amount.

In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol to remain in the bloodstream, leading to hyperlipidemia.

The healthy ratio of total blood cholesterol ("bad"/ "good") is any number that is less than 4.

Patients with hyperlipidemia are asymptomatic. However, over time hyperlipidemia can cause plaque to accumulate on the arterial wall, leading to atherosclerosis, a major cause of heart disease and stroke.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.

Some researchers suggested that the hyperlipidemic prevalence in the Western world may correlate to the promotion of a high-fat diet over the past few decades.

Dr. Karam I, the lead scientist in examing the said, "Hyperlipidemia, a group of metabolic disorders characterized by the elevated levels of lipids, is a major modifiable risk factor for atherosclerosis and cardiovascular disease [5]. These lipids include cholesterol, cholesterol esters, phospholipids, and triglycerides. Increased levels of LDL are related to the development of atherosclerosis [15,16].


And, "The result showed that there was a significant increase in hyperlipidemia biomarker which includes TC, TG, LDL, and HDL. There were histological changes in organs which confirm the previous result of blood lipid. That means high-fat diet successfully induces hyperlipidemia in rats, to make disease model of hyperlipidemia.".

The life-long condition of hyperlipidemia is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of heart disease, researchers examined the effects of Ashwagandha on lowering blood cholesterol.

The study included rats induced by a high-fat diet treated by aqueous extract of fruits of Withania coagulans for 7 weeks.

According to the tested analysis during the experiment, administration of the extract showed a significantly reduced elevated serum cholesterol, triglycerides and lipoprotein levels.


In triton-induced hypercholesterolemia., the aqueous extract of fruits of Withania coagulans exerted a significantly hypolipidemic activity.

Furthermore, according to the tested analysis of the liver tissues of treated hyperlipidemic rats, the extracts also inhibited the degenerative changes, compared to hyperlipidemic controls.

Based on the findings, researchers said, "The hypolipidemic effect of W. coagulans fruits was found to be comparable to that of an Ayurvedic product containing Commiphora mukkul".

Taken altogether, Ashwagandha may be considered a functional herb for lowering blood cholesterol, pending the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypolipidemic and antioxidant activity of aqueous extract of fruit of Withaniacoagulans (Stocks) Dunal in cholesterol-fed hyperlipidemic rabbit model by Shukla K, Dikshit P, Shukla R, Sharma S, Gambhir JK. (PubMed)
(2) Hypolipidemic activity of aqueous extract of Withania coagulans Dunal in albino rats by Hemalatha S1, Wahi AK, Singh PN, Chansouria JP. (PubMed)
(2) Induce Hyperlipidemia in Rats Using High Fat Diet Investigating Blood Lipid and Histopathology by Karam I, Ma N, Yang Y-J, and Li J-Y. (The Journal of Hematology and Blood Disorders)

Herbal Arctostaphylos uva-ursi, the Anti Diabetes Functional Remedy

Scientists may have found a medicinal plant for the treatment of diabetes with no side effects, according to the studies.

Diabetes is a medical and chronic condition characterized by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes is a result of abnormally and chronically high levels of sugar (glucose) in the blood. Insulin resistance is a hallmark of diabetes. The disease is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

Insulin receptors are areas on the outer part of a cell that allow the cell to bind with insulin in the blood. When the receptors are clogged up, the cell can not take glucose (sugar) from the blood and use it for energy.

Researchers do not know what causes insulin resistance in diabetic patients. However, researchers do know that long-term intake of a poor diet with high saturated and trans fat, red meat, and processed food is one of many risk factors associated with clogging up the insulin receptors sites, leading to high blood glucose.


Dr. David Hefner in the concern of the Western diet linked to type 2 diabetes, wrote, "The researchers surveyed 42,000 men over a 12-year period. The men's eating habits were divided into two groups: those who followed a Western diet and those who followed a "prudent" diet with fruit, vegetables, whole grain, fish and poultry. "Over the course of the study ... 1,321 new cases of Type 2 diabetes were diagnosed".


These results clearly suggested that by changing to a healthy diet pattern with high fruits and vegetables and reducing the intake of saturated and trans fat, red meat, and processed food, diabetes is preventable.


Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as a diuretic agent and for the treatment of urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.

The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.

Finding a natural formula for the treatment of diabetic symptoms that leads to the investigation of 7 plants and a herbal mixture used for the traditional treatment of diabetes in streptozotocin-diabetic mice conducted by the University of Ulster.

In streptozotocin diabetic mice, the formula was supplied as 6.25% by weight of the diet for 9 days.


The consumption of diets containing bearberry (Arctostaphylos uva-ursi), significantly reduced the excessive hunger and abnormally large intake of solids and excessive thirst or excess water drinking associated with streptozotocin diabetes.

However, other herbal plants in the herbal formula such as bayberry (Cinnamomum tamala), meadowsweet (Filipendula ulmaria), Senna (Cassia occidentalis), and the herbal mixture did not alter these parameters.

Bearberry, mistletoe, and tarragon retarded body weight loss, and reduced symptoms of diabetes without significantly altering plasma glucose or insulin concentrations.

The results suggested that only bearberry, goldenseal, mistletoe, and tarragon can counter some of the symptoms of streptozotocin diabetes without affecting glycemic control.


Taken altogether, bearberry (Herbal Arctostaphylos uva-ursi) may be used as a functional remedy for the treatment of some diabetic symptoms, pending the confirmation of large sample size and multicenter in a human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR.(PubMed)
(2) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)

Dandelion(Taraxacum officinale) May Process Anti-Intestinal Metaplasia (IM) and Atypical Hyperplasia (AH), Researchers Say

 The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.

The stomach plays a critical role in aiding the digestive system by secreting acid and enzymes that digest food induced by the stomach muscles that contract periodically, to churn the food and enhance digestion.

Atypical hyperplasia is a precancerous condition characterized by the accumulation of abnormal cells.

Intestinal metaplasia is a pre gastric cancer condition caused by the change of cells in the stomach.


The exact causes of the condition are unknown. However, some researchers suggested that smoking and infection caused by H. pylori infection, genetic preposition, and environmental factors are some risk factors associated with the onset of intestinal metaplasia.

Gastric cancer is a medical condition characterized by irregular and uncontrollable cell growth in the stomach lining in the beginning. At the advanced stage, the malignant cells can travel a distance away through blood and fluid circulation to infect other healthy tissue and organs.

Researchers do not know why some people with the same health condition are susceptible to the risk of gastric cancer, while others do not. The exact causes of gastric cancer are also unknown. However, some researchers suggested that Age, diet, and stomach disease, such as can increase the risk of developing gastric cancer.


Both atrophic gastritis and gastric cancer share the common symptoms of stomach pain, nausea and vomiting, loss of appetite,... and indigestion. However, common symptoms of unexpected weight loss and stomach ulcers can only be found in gastric cancer while iron deficiency anemia is found in the majority of patients with atrophic gastritis.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).

Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of gastric diseases, scientists examined the efficacy of Xiao Wei Yan Powder (XWYP) decoction on intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH).

Where XWYP is a traditional Chinese Medicine formula containing Smilax glabrate, Hedyotis diffusae, Taraxacum mongolicum, Caesalpinia sappan, Paeonia alba, Cyperus rotundus, Bletilla striata, Glycyrrhiza uralensis, etc.

According to the results of 138 cases of intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH) of the gastric mucosa of chronic gastritis that was treated by Xiao Wei Yan Powder (XWYP) orally 5-7g, for a period from 2-4 months, compared to control, the decoction showed a significant effect rate of IM was 91.3% and that of the AH was 92.16% compared to the control group of 21.3% and 14.46% respectively.

More precisely, XWYP not only had marked therapeutic effects for IM and AH but also showed no toxic effects in the animal experiments revealed no toxic effect,

These results strongly suggested that a safety guarantee was provided for its clinical application.


Taken altogether, Dandelion in a combination with other Chinese medicines may be considered a remedy for the treatment of intestinal metaplasia and atypical hyperplasia (AH), pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Treatment of intestinal metaplasia and atypical hyperplasia of gastric mucosa with xiao Wei yan powder].[Article in Chinese] by Liu XR1, Han WQ, Sun DR. (PubMed)

Herbal Turmeric Inhibits the Onset and Progression of Chronic Prostatitis

Prostatitis is a condition associated with the inflammation of the prostate and the areas around the prostate.


According to the statistics provided by the American Family Physician, approximately 8.2 percent of men in the US are living with prostatitis. The conditions account for 8 percent of visits to urologists, and up to 1 percent of visits to primary care physicians.

Believe it or not, in 2000, prostatitis cost over $84 million, including the charge of diagnosis and treatment.


The most common symptoms of prostatitis are painful, difficult, and/or frequent urinating, groin pain, rectal pain, abdominal pain and/or low back pain, fever, chills, and body aches.

In severe cases, patients may also experience symptoms of urethral discharge, painful ejaculation or sexual dysfunction, and blood in the urine.

The exact causes of prostatitis are not identified, some researchers suggested that nerve damage in the lower urinary tract caused by surgery or trauma to the area has been found to induce prostatitis in patients.

Conventionally, most cases of prostatitis are treated by antibiotics in cases of infection, alpha-blockers to relax the bladder neck, and muscle fibers, and anti-inflammatory medicine to ease pain and discomforts.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.


The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential and natural ingredient for the treatment of inflammatory diseases such as chronic prostatitis/ chronic pelvic pain syndrome type III (CP/CPPS), researchers examined the effect of turmeric on chronic bacterial prostatitis.

Phase II, the randomized, single-blinded, placebo-controlled clinical trial included 60 patients who were examined by the University of Catania from June 2015 to January 2016 we enrolled 60 consecutive due to CP/CPPS III.

At the end of the experiment, the treatment group showed a significant improvement in the National Institutes of Health Chronic Prostatitis Symptom Index, IIEF-5 (+ 3.5; p < 0.01), particularly other symptomatic parameters compared to placebo.


Participants were then allocated to receive treatment (Group A) or placebo(Group B). Treatment consisted of rectal suppositories of Curcumin extract 350 mg (95%) and Calendula extracts 80 mg (1 suppository/die for 1 month). Patients of Group B received 1 suppository/die for 1 month of placebo.

The efficacy of the treatment with Curcumin and Calendula was associated with the reduction of inflammatory cytokines and of inflammatory cells.


Based on the findings, Dr. Morgia G, the lead researcher said, "In this phase II clinical trial, we showed the clinical efficacy of the treatment with Curcumin and Calendula in patients with CP/CPPS III".

Taken altogether, turmeric used alone or combined with Calendula may be considered supplements for the prevention and treatment of chronic bacterial prostatitis and chronic pelvic pain syndrome, pending the confirmation of the larger sample size and multicenter human study.



Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III by Morgia G1, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)

Fennel, The Natural Free Radical Scavenger, Scientists Find

Fennel may be the next generative functional food with the potency in blocking the overexpression of free radicals in the induction of chronic illness, some scientists suggested.

Free radicals are highly reactive molecules with an unpaired electron that cause oxidation by stealing an electron from other molecules to give rise to a chain activity. Once free radical starts its domino effect, it can not be stopped until two free radical species react with each other to form a stable, non-radical adduct or are inhibited by the presence of antioxidants.

Antioxidants, on the other hand, are stable molecules that inhibit oxidation caused by free radicals.

The relationship between free radicals and antioxidant are summarized by Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health ", "A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress".

These explanations suggested that intake of antioxidants from the food sources in the stimulation of antioxidant enzymes in the body is beneficial in maintaining good health, However, the doctors continued, "Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".



Overexpression of free radicals or imbalance of the ratio of free radicals and antioxidants in the body can initiate oxidative stress. A prolonged period of oxidative stress in the human body plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, and cardiovascular and neurodegenerative diseases.

Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The functional herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...

Fennel is an excellent source of natural antioxidants and contributed to the daily antioxidant diet. The functional food is found to process a free radical scavenging activity, particularly in the application of its phenolic and flavonoid.

In the examine the effects of fennel essential oil in the presence of overexpression of free radicals, researchers found, that injection of the oil exerts a strong antioxidant activity in comparison with butyrated hydroxyanisole and butylated hydroxytoluene., however, injection of ethanol and water extracts of fennel showed less effective compared to essential oil.

Furthermore, in the evaluation of the essential oils of the fruits of three organically grown cultivars of Egyptian fennel (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce, and Foeniculum vulgare var. vulgare) in antibacterial and antioxidant effects, researchers showed that all three cultivars contain a great source of trans-Anethole, estragole, fenchone, and limonene.


All phytochemicals demonstrated significant activity in free radical scavenging, inhibited lipid peroxidation, and metal chelation.


Additional differentiation suggested that essential oils from the azoricum and dulce cultivars were more effective antioxidants than that from the vulgare cultivar and essential oils from 3 species display similar antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.

More importantly, in the examine the effect of essential oil on fennel (Foeniculum vulgare) lipophilic secondary metabolites, researchers at the Avicenna Tajik State Medical University, discovered that
* The oil exhibited moderate antioxidant activities.

* The antioxidants in the essential oil are found to protect the healthy cells and stimulate the expression of free radicals in exerting cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukemia) and CEM/ADR5000 (adriamycin resistant leukemia) cancer cell lines;

* The most effective of the IC50 values are between 30-210 mg L-1.



These results suggested essential oil from fennel is processed as a great source of antioxidants with the function of balancing the ratio of free radicals in the body, thus preventing the initiation of oxidative stress.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA(PubMed)
(3) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)