Tuesday, March 29, 2016

Most Common Diseases of elder: Respiratory Pleural disease: Pleural Plaques - The Causes and Risk factors

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

                   Pleural disease: Pleural Plaques

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural plaques is a medical condition as a result of exposure to asbestos that lead to accumulated plagues within the pleural cavity(a). Many diseases such as pneumonia, breast cancer, and heart failure can affect the pleural space.,therefore, it is often a secondary effect of another disease process.

                           Causes and Risk factors

The Causes
The common cause of pleural plaques development is exposure to asbestos.
1. ErioniteErionite, a fibrous zeolite mineral, has been categorized as a class I carcinogenic agent for its causative role in mesothelioma. According to the study by the University of Pittsburgh School of Medicine, in select villages in Turkey, erionite is the cause of more than 50% of mesotheliomas, but there is a report of a first case of a patient with erionite-associated pleural mesothelioma with classic pathologic changes typical of asbestos-related pulmonary and pleural pathology(5).

2. Chrysotile and tremolite
Environmental exposures to chrysotile and tremolite from the soil cause pleural plaques and mesothelioma in northeast Corsica, according to the study by the Chest Department, CUB Hôpital Erasme in a study of natural animal model to determine whether these exposures actually result in increased fibre burdens in the lungs and parietal pleura(6).

The Risk factors
1. Occupations
People who work in prolonged environment in exposure to asbestos are at increased risk of pleural plaques. According to the study of Pleural plaques in dentists from occupational asbestos exposure, by the Pulmonary Clinic of Aristotle University of Thessaloniki, everyday occupational exposure for many years even to low asbestos levels, under poor ventilation conditions in a closed space, could cause pleural lesions(7).

2. “Take-home” asbestos
According to the study by the Occupational Medicine Clinic, General Health Services, Providers should recognize that due to the potential for “take-home” exposures, asbestos-related disease in a patient may be a marker for disease in household contacts. Patients with family members heavily exposed to asbestos should be strongly encouraged to quit smoking in an effort to reduce any further carcinogenic exposures. Additionally, workplace control and regulation of asbestos use should be emphasized to protect both workers and their families(8).

3. Asbestos exposure and Cigarette smoking
In a survey of 45 men aged 40 or over who had worked five years or more in an asbestos manufacturing plant, the prevalence of pleural plaques was studied with respect to age, duration of asbestos exposure, estimated cumulative asbestos dose, and smoking habit. Plaques were found in 38 to 53% of the men, depending on the interpretation of the chest film reader. Cigarette habit appeared to be the most important factor; the prevalence was lowest in non-smokers, intermediate in current smokers, and particularly high in exsmokers(9).
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Monday, March 28, 2016

The Smoothie of Cooked Sweet Potato, Olive and Grape Juice for Prevention and Treatment of Adenine phosphoribosyltransferase deficiency (Chronic kidney disease (CKD)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Adenine phosphoribosyltransferase deficiency (Chronic kidney disease (CKD)
Yield: 2 servings (about 8 ounces each)

1/2 cup olive
1 cup cooked sweet potato
1 cup organic grape juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Chronic Kidney Diseases(CKD) in Adenine phosphoribosyltransferase deficiency has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

 Adenine phosphoribosyltransferase deficiency is an inherited metabolic disorder associated to excessive production of 2,8-dihydroxyadenine (DHA), affecting the kidneys and urinary tract.
Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice  may be the next generation of natural ingredients for prevention and treatment of Chronic kidney disease (CKD) in Adenine phosphoribosyltransferase deficiency.
According to the study led by the University of Iceland, Progressive chronic kidney disease (CKD) and acute kidney injury (AKI) episodes are major features of APRT deficiency, whereas kidney stone is the most common presentation(11).

Chronic Kidney Diseases(CKD) is a progressive loss of kidney function over period longer than 3 months through different stages, deepening to the GFR (Glomerular Filtration Rate). According to the Tri-Service General Hospital, Excessive oxidative stress increased oxidative nucleicacid damage and exagerated the development of complication of Chronic Kidney Diseases(1).

The Anti-Odxidant Therapy in Chronic Renal Insufficiency (ATIC) study suggested, combination of pravastatin, vitamin E, and homocysteine treatment in 18 months together with hypertension controlled  effectively attenuated expression of Chronic Kidney Diseases(CKD) through reduced oxidative stress against renal function(2).Vitamin E-coated membranes (VECMs) consist of a multilayer membrane with liposoluble vitamin E, used in dialysis significantly improved Hb levels and lower rHuEpo requirements in chronic HD patients(3).Dr. Rashid Khan M and colleagues insisted, vitamin E significantly reduced dyslipidemia and inhibited the development of CRD caused by atherogenic factors after six weeks. particular in hypolipidemic and nephroprotective activity against free radical-related diseases(4).

N-3 fatty acids found abundantly in olive may also contribute to the potential benefits of dietary fat
modification in CKD patients, according to the Karolinska Institutet(5).
Dr. Lee SM and Dr. An WS., professors at the Seoul National University Hospital, insisted, intake of Omega 3 fatty acid exhibited cardioprotective effects in chronic kidney disease, the main cause of death, through attenuated inflammation, dyslipidemia, malnutrition, atherosclerosis, and vascular calcification(6).
Dr. Friedman AN said, " Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA), which are obtained primarily from dietary sources such as coldwater fish, have diverse and potent mediating effects on the immune, inflammatory, and metabolic pathways, signal transduction, and cell membrane physiology" and "In the meantime, the current American Heart Association n-3 PUFA intake guidelines can be applied to CKD patients"(7).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry, may also benefit in attenuated complications and treatment of Chronic Kidney Diseases(CKD), through its inflammation and oxidative stress modulation (8).
According to the joint study led by the The Catholic University of Korea, Bucheon, resveratrol expressed renoprotective effects by activating NRF2 signaling against against oxidative or electrophilic stress(9).Furthermore by suppressing the pro inflammatory cytokines, consumption of white wine and olive oil, significantly reduced plasma markers of chronic inflammation in CKD patients(10).

The effectiveness of Cooked Sweet Potato, Olive and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Chronic Kidney Diseases(CKD) in Adenine phosphoribosyltransferase deficiency with little or no adverse effects.

People who are at high risk of Chronic Kidney Diseases(CKD) in Adenine phosphoribosyltransferase deficiency due to aging, weaken reno function... should drink at least one serving daily and People with Chronic Kidney Diseases(CKD) in Adenine phosphoribosyltransferase deficiency should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.



References
(1) Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease by Sung CC1, Hsu YC, Chen CC, Lin YF, Wu CC.(PubMed)
(2) Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study by Nanayakkara PW1, van Guldener C, ter Wee PM, Scheffer PG, van Ittersum FJ, Twisk JW, Teerlink T, van Dorp W, Stehouwer CD.(PubMed)
(3) Effect of vitamin E-coated dialysis membranes on anemia in patients with chronic kidney disease: an Italian multicenter study by Cruz DN1, De Cal M, Garzotto F, Brendolan A, Nalesso D, Corradi V, Ronco C.(PubMed)
(4) Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats by Rashid Khan M1, Ahsan H, Siddiqui S, Siddiqui WA.(PubMed)
(5) Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond by Huang X1, Lindholm B, Stenvinkel P, Carrero JJ.(PubMed)
(6) Cardioprotective effects of ω -3 PUFAs in chronic kidney disease. by Lee SM1, An WS.(PubMed)
(7) Omega-3 fatty acid supplementation in advanced kidney disease by Friedman AN1.(PubMed)
(8) Resveratrol: why is it a promising therapy for chronic kidney disease patients?by Saldanha JF1, Leal Vde O2, Stenvinkel P3, Carraro-Eduardo JC4, Mafra D1.(PubMed)
(9) Effect of redox modulating NRF2 activators on chronic kidney disease.by Choi BH1, Kang KS2, Kwak MK3.(PubMed)
(10) Anti-inflammatory effect of white wine in CKD patients and healthy volunteers by Migliori M1, Panichi V, de la Torre R, Fitó M, Covas M, Bertelli A, Muñoz-Aguayo D, Scatena A, Paoletti S, Ronco C.(PubMed)
(11) Kidney Disease in Adenine Phosphoribosyltransferase Deficiency. by Runolfsdottir HL1, Palsson R2, Agustsdottir IM3, Indridason OS4, Edvardsson VO5.(PubMed)







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Most Common Diseases of elder: Respiratory Pleural disease: Pleural Plaques - The Symptoms

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

                   Pleural disease: Pleural Plaques

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural plaques is a medical condition as a result of exposure to asbestos that lead to accumulated plagues within the pleural cavity(a). Many diseases such as pneumonia, breast cancer, and heart failure can affect the pleural space.,therefore, it is often a secondary effect of another disease process.

                                                           Symptoms

1. Restrictive lung function
Long term exposure to asbestos can cause thicken of the pleura of that can interfere with breathing of the lung. According to the study by the Caen University Hospital, isolated parietal and/or diaphragmatic pleural plaques were associated with a significant decrease in total lung capacity (TLC) (98.1% predicted in subjects with pleural plaques vs. 101.2% in subjects free of plaques, p=0.0494), forced vital capacity (FVC) (96.6% vs. 100.4%, p<0.001) and forced expiratory volume in 1 s (FEV(1)) (97.9% vs. 101.9%, p=0.0032). In contrast, no significant relationship was observed between pleural plaques and FEV1/FVC ratio, forced expiratory flow at 25-75% FVC and residual volume(1).

2. Dyspnea
In the study to compare of one hundred thirty subjects who were found to have pleural plaques and with 1,103 control subjects who had no plaques and showed no changes on x-ray examination, found that no difference in occurrence of thoracic pain was found between the two groups. Dyspnea was more common among patients with pleural plaques, who also tended to have lower lung function values(2).

3. Chronic sputum, dyspnea, and chest pain
In the study to compare the Prevalence of respiratory symptoms and pulmonary function tests in the DPT and PP groups resulting from the two definitions of DPT, showed that chronic sputum, dyspnea, and chest pain was significantly higher in this group than in the PP group(3).

4. Significant reduction in FEV1 and FVC
According to the study by the Division of Disease Prevention and Control, Minneapolis, in Compared with workers with normal pleura, workers with plaques had a decreased mean percentage for predicted forced vital capacity (FVC) and predicted forced expiratory volume in 1 s (FEV1.0)patient with decreased mean percentage for predicted forced vital capacity (FVC) and predicted forced expiratory volume in 1 s (FEV1.0)(4).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sunday, March 27, 2016

The 50plus health Smoothie of Carrot, Olive and Curcumin for Prevention and Treatment of Poor Vision in Conorenal syndrome

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Conorenal syndrome, also known as Mainzer-Saldino syndrome or Saldino-Mainzer disease is a medical condition of diseases involved kidney, skeletal system and eye.

Poor vision in Conorenal syndrome is a result of a progression of degeneration of photosensitive tissue of the retina in both eyes of patient since infancy.
Treatment of poor vision with natural sources may be helpful to prolong at least and prevent the destruction of the photosensitive tissues

The smoothie at least prolong and prevention of poor vision in Conorenal syndrome 
Yield: 2 servings (about 8 ounces each)

1/2 cup carrot
1 cup olive
1 tsp curcumin
1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The finding of a natural source for treatment of Poor Vision in Conorenal syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of poor vision in Conorenal syndrome.

Carotene, an orange or red plant pigment and a precursor of vitamin A found abundantly in carrot and tomato may benefits patient with poor vision(1) in Conorenal syndrome. According to Case Western Reserve University, synthetic 9-cis-stereoisomers of vitamin A (all-trans-retinol) are especially promising agents for the fight against poor vision and blinding diseases(3).
According to the University of California, in the study of Nightblind pregnant women randomly assigned to 1 of 6 treatment groups to receive 6 d/wk for 6 wk either 850 microg retinol equivalents/d as retinyl palmitate indicated a significantly increase plasma retinol concentrations in improvement of night vision but do not difference than those who received vitamin A as liver, amaranth leaves,carrots(2).
In support the above, the London School of Hygiene & Tropical Medicine, insisted use of antioxidant vitamin or mineral supplementation such as beta-carotene, vitamin C and vitamin E may delay the progression of age-related macular degeneration disease, but more studies may be necessary to validate these claim(6).

Omega 3 fatty acid found abundantly in flax seed and olive may help improvement of poor vision(4).
Dr. Lawrenson JG and Dr. Evans JR. said, "omega 3 LCPUFA supplementation in people with AMD for periods up to five years does not reduce the risk of progression to advanced AMD or the development of moderate to severe visual loss"(5) of these may be beneficiary to the progression of vision loss of genetic mutation in Conorenal syndrome.
Furthermore, intake of Omega 3 fatty acids also showed to alleviate dry eye symptoms, decrease tear evaporation rate and improve Nelson grade in patients suffering from computer vision syndrome related dry eye(7).

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. Its phytochemical curcumin is found effectively for treatment of eye disorder(8).
In corneal neovascularization, a leading cause for compromised vision, curcumin significant improven and prevent of corneal neovascularization by suppression in the expression of VEGF controlled by growth factors and cytokines, inflammatory cytokines,,..(9).
The Vision Research Foundation, Sankara Nethralaya study also showed that curcumin suppresses the expression and function of MDR1, the multidrug resistance-associated protein 1(10).

The effectiveness of  Carrot, Olive and Curcumin may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of poor vision in Conorenal syndrome with little or no adverse effects.

Senior who are at high risk of poor vision in Conorenal syndrome due to mutation gene should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.




References
(1) Carrots, carotene and seeing in the dark by Smith W1, Mitchell P, Lazarus R.(PubMed)
(2) Recovery from impaired dark adaptation in nightblind pregnant Nepali women who receive small daily doses of vitamin A as amaranth leaves, carrots, goat liver, vitamin A-fortified rice, or retinyl palmitate By Haskell MJ1, Pandey P, Graham JM, Peerson JM, Shrestha RK, Brown KH.(PubMed)
(3) Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis by Maeda T1, Perusek L, Amengual J, Babino D, Palczewski K, von Lintig J.(PubMed)
(4) Omega-3 for your eyes. Research finds DHA may help preserve your vision. [No authors listed](PubMed)
(5) Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration by Lawrenson JG1, Evans JR.(PubMed)
(6) Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration by Evans JR1, Lawrenson JG.(PubMed)
(7) Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye by Bhargava R1, Kumar P2, Phogat H3, Kaur A3, Kumar M4.(PubMed)
(8) A New Insight of Herbal Promises Against Ocular Disorders: An Occuloinformatics Approach by Srivastava P1, Tiwari A.(PubMed)
(9) Curcumin nanoparticles inhibit corneal neovascularization by Pradhan N1, Guha R2, Chowdhury S2, Nandi S2, Konar A3, Hazra S4.(PubMed)
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Most Common Diseases of elder: Respiratory Pleural disease: Pleural effusion Treatment In traditional Chinese Medicine

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

                   Pleural disease: Pleural effusion

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural effusion is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.

                     The Treatment
Treatments in traditional Chinese medicine perspective
1. Volatile oil of Centipeda minima
According to the study by the Affiliated Hospital of Guiyang Medical College, VOCM has a protective effect on acute pleural effusion in rats induced by an intrapleural injection(109).

2. Angelicae decursiva, Poncirus trifoliata and Polygonatum odoratum
Betaine, coumarin, hesperidin and kaempferol are the components derived from Lycium chinense, Angelicae decursiva, Poncirus trifoliata and Polygonatum odoratum, respectively. According to the study by the Chungnam National University, (i) Coumarin and kaempferol did not affect mucin release significantly; (ii) Betaine and hesperidin increased mucin release at the highest concentration; (iii) Poly-L-lysine inhibited and adenosine triphosphate increased mucin release. We conclude that betaine and hesperidin can increase mucin release by direct acting on airway mucin-secreting cells and suggest these agents be further studied for the possible use as mild expectorants during the treatment of chronic airway diseases(110).

3. TCM herbal granules
In the study of a patient with unilateral pleural effusion secondary to congestive heart failure with traditional Chinese herbal formulas treated with TCM herbal granules including Shengmaisan, Xiebaisan, and Tinglizi, 3 times a day for 4 weeks, showed that TCM herbal formulas could play an important role in preventing the progression of unilateral pleural effusion secondary to CHF, in case of poor response to conservative treatment. Additional studies about the mechanism of action of the medication involved are warranted(111).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Saturday, March 26, 2016

The Smoothie of formula RRF and Flax Seed for Reduced Symptoms of Perimenopause

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced symptoms and treatment of Perimenopause 
Yield: 2 serving (about 8 ounce each)
1 gram of formula RRF(you cam buy them in any Chinese herbal store)
1/2 cup of flax seed
1 cup of grape
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for reduced symptoms and treatment of Perimenopause  is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine.
Unfortunately, many compounds found effective in initial studying failed to confirm the potentials in large sample size and multi center.

Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, from Radix Astragali (RA), Radix Angelicae Sinensis (RAS) and Folium Epimedii (FE), three of the extensively applied herbs among traditional Chinese medicines for gynecological disorders(1), including symptoms of Perimenopause.

Long-term treatment of RRF formula exhibited estrogenic properties, inhibited age-associated egeneration may be considered as an alternative/complementary medicine in relieving perimenopausal symptoms(1), according to the joint study lead by the Guangzhou University of Chinese Medicine.

Huang Qi or Bei Qi is also known as Astragalus root. The sweet herb has been used as diuretic agent and to lower blood pressure, increase blood pressure, lessens proteinuria, improve endurance, protect liver function, regulate blood sugar, etc.

In natural aging animal study, Radix Astragali used conjuction with Radix Angelicae Sinensis, and Folium Epimedii in formula RRF, expressed a a positive regulation on the estrogen imbalance and neurotransmitter disorder in restoring reproductive organ degeneration and skeleton deterioration in perimenopausal rats(2).

According to the Guangzhou University Town, RRF also enhanced estradiol (E(2) synthese while diminished the elevated serum FSH and LH levels, attenuated osteoporosis by elevating the BMD levels of total body and bone trabeculae degradation of which induced a capable of acting at multiple targets in the protection and treatment of perimenopausal disorders in midlife women(3).

Furthermore, RRF on study of immunological function, RRF also displayed a relatively wide margin of safety. Dr. Xie JH and colleagues at the joint study lead by the Guangzhou University of Chinese Medicine, Guangzhou said, "Long-term treatment of RRF exhibited estrogenic properties, and retarded certain age-associated degenerations" and "RRF might have the potential for further development as a safe and effective alternative/complementary to conventional medication in relieving perimenopausal symptoms."(4).

On Chinese medicinal plant Radix astragali(RA) alone in the study of 24 ovariectomized female Sprague-Dawley (SD) rats, oral application of RA significantly improved the immune functions of the ovariectomized female rats, but cannot induced the change the sex hormones levels as significantly as estrogen(5).

Dang Qui (Angelica sinensis) is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. Use conjunction with Radix Astragali and Folium Epimedii in formula RRF improved the aging degeneration of perimenopausal symptoms in animal study(2).

Folium Epimedii, deciduous or evergreen hardy perennials, native to Asia, and a few in the Mediterranean region has been used in Chinese medicine for induced sexual activity. When used together with Dang qui and Huang qi in formula RRF has shown effectively in enhanced the balancing of diminished hormones due to aging in reduced the expression of perimenopausal symptoms(3).

In take of phytoestrogen with function as weak estrogens, antioxidants, and anti-inflammatory agents(6) plant based lignans, a chemical compoud found in flax seed, may be effective in ameliorated symptoms of peri menopause, according to the joint study lead University of Zurich(7),

The combination of formula RRF and Flax Seed  smoothie may hold a key in further studies in production of an effective natural ingredients for reduced the symptoms displacement and treatment of perimenopause without inducing adverse effects.

Women who are in the perimenopause stage should drink as much as they can, depending to the digestive toleration.



References
(1) Evaluation of safety of Modified-Danggui Buxue Tang in rodents: Immunological, toxicity and hormonal aspects by Xie JH1, Chen ZW2, Pan YW3, Luo DM3, Su ZR4, Chen HM1, Qin Z5, Huang SQ6, Lei G7.(PubMed)
(2) Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: An In Vivo Study on Natural Aging Rat Model by Su JY1, Xie QF2, Liu WJ1, Lai P1, Liu DD1, Tang LH1, Dong TT3, Su ZR4, Tsim KW3, Lai XP4, Li KY5.(PubMed)
(3) Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats by Xie QF1, Xie JH, Dong TT, Su JY, Cai DK, Chen JP, Liu LF, Li YC, Lai XP, Tsim KW, Su ZR.(PubMed)
(4) Evaluation of safety of Modified-Danggui Buxue Tang in rodents: Immunological, toxicity and hormonal aspects by Xie JH1, Chen ZW2, Pan YW3, Luo DM3, Su ZR4, Chen HM1, Qin Z5, Huang SQ6, Lei G7.(PubMed)
(5) Effects of a Chinese medicinal plant Radix astragali on the ovariectomized female rats by Zheng Y1, Jin Y, Zhu HB, Xu ST, Xia YX, Huang Y.(PubMed)
(6) Urinary phytoestrogen levels and frailty in older American women of the National Health and Nutrition Examination Survey (NHANES) 1999-2002: a cross-sectional study by Eichholzer M1, Richard A, Walser-Domjan E, Linseisen J, Rohrmann S.(PubMed)
(7)  Urinary phytoestrogens and depression in perimenopausal US women: NHANES 2005-2008. by Richard A1, Rohrmann S2, Mohler-Kuo M3, Rodgers S4, Moffat R5, Güth U6, Eichholzer M2.(PubMed)
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Most Common Diseases of elder: Respiratory Pleural disease: Pleural effusion Treatments in Herbal medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                   Pleural disease: Pleural effusion

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural effusion is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.

                     The Treatment



Treatments in Herbal medicine perspective
1. Cordia verbenacea
In the study to evaluate the anti-inflammatory and anti-allergic effects of the essential oil of Cordia verbenacea (Boraginaceae) and some of its active compounds, indicated that treatment with the essential oil of Cordia verbenacea (300-600mg/kg, p.o.) reduced carrageenan-induced rat paw oedema, myeloperoxidase activity and the mouse oedema elicited by carrageenan, bradykinin, substance P, histamine and platelet-activating factor. It also prevented carrageenan-evoked exudation and the neutrophil influx to the rat pleura and the neutrophil migration into carrageenan-stimulated mouse air pouches(105).

2. Taraxacum
The genus Taraxacum is a member of the family Asteraceae, subfamily Cichorioideae, tribe Lactuceae and widely distributed in the warmer temperate zones of the Northern Hemisphere. pharmacologically relevant compounds of Taraxacum characterized so far and of the studies support of its use as a medicinal plant. Particular attention has been given to diuretic, choleretic, anti-inflammatory, anti-oxidative, anti-carcinogenic, analgesic, anti-hyperglycemic, anti-coagulatory and prebiotic effects(106).

3. Scutellaria baicalensis, Coptis japonica, Curcuma longa and Poncirus trifoliata
Baicalein, berberine, curcumin and hesperidin are the major components derived from Scutellaria baicalensis, Coptis japonica, Curcuma longa and Poncirus trifoliata, respectively. According to the study by the Chungnam National University, berberine, curcumin and hesperidin can increase mucin release by directly acting on airway mucin-secreting cells and suggest that these agents be further studied for possible use as mild expectorants during the treatment of chronic airway diseases(107).

4. Scutellaria baicalensis Georgi
Scutellaria baicalensis Georgi has been used for the treatment of diverse chronic inflammatory diseases including respiratory disease in oriental medicine and its major components, baicalin, baicalein and wogonin – were reported to have various biological effects. According to the study by the Chungnam National University,baicalin and wogonin can slightly increase basal mucin release whereas they can inhibit ATP-induced mucin release, by directly acting on airway mucin-secreting cells. It is suggested that baicalin and wogonin be further investigated for the possible use as mucoregulators during the treatment of chronic airway diseases(108).

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