Tuesday, May 31, 2016

Most common Diseases of 50plus: The Obesity' Research and Studies of Dietary carbohydrate and fat and diabetes

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Research and Studies of Dietary carbohydrate and fat and diabetes

In the review of the emphasis in recent years has been on the reduction of total fat and saturated fat and replacement with complex carbohydrate. Scientist from the Stanford University School of Medicine(1) indicated that there is little evidence to support the notion that low-fat high-carbohydrate diets per se lead to any reduction in the risk for CAD in individuals with diabetes from the available data, but the only data indicating that low-fat high-carbohydrate diets lead to beneficial effects on carbohydrate and lipoprotein metabolism are confounded either by the lack of suitable experimental control. The group said that diets also differed in the type of dietary fat and amount of dietary cholesterol, or were enormously enriched in dietary fiber. When these factors are taken into consideration, there appears to be little evidence in support of the view that substituting carbohydrate for fat in the diets of individuals with diabetes results in any measurable beneficial effect.
The group continued that indeed, it could be argued that the most characteristic defects in carbohydrate and lipoprotein metabolism are exacerbated in response to low-fat high-carbohydrate diets. Alternatively, the data presented herein strongly suggest that diets containing conventional quantities of fat, in which saturated fat is replaced by unsaturated fat and dietary cholesterol reduced, would result in the desired reductions to total and low-density lipoprotein cholesterol concentrations without the adverse effects of increased postprandial glucose and insulin concentrations, increased fasting and postprandial total and very-low-density lipoprotein triglyceride concentrations, and decreased fasting high-density lipoprotein cholesterol concentrations.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

(1) "Effects of dietary carbohydrate and fat intake on glucose and lipoprotein metabolism in individuals with diabetes mellitus" by Hollenbeck CB, Coulston AM., posted in PubMed

Most common Diseases Free and Longevity of 50 plus - Organic Soy Part A By Healthy Foods Soy Sauce

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)

The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.

Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".

Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.

                                     Soy sauce

Soy sauce is a seasoning produced by fermenting soybeans and filamentous fungus, along with water and salt after a period of sometime, it yields a moromi or thick mash of cereal to obtain soy sauce by pressing it to liquid form. Tamari is made by collecting the liquid which was pressed and the liquid drained drains from miso after a certain time of fermentation.

Nutrients
1. Sodium
2. protein
3. Fat
4. Niacin (Vitamin B3)
5. Iron
6. Manganese
7. Magnesium
7. Phosphorus
8. Riboflavin
9. Vitamin B6
10. Isoflavones
11. Etc

I. Health benefits by Healthy Food Soy Sauce
A. Health benefits according to studies
1. Cardiovascular health
In the investigation of dietary proteins and their effect in heart diseases found that a direct cholesterol lowering effect of proteins has not been shown. Despite earlier research indicating that soy protein has cardioprotective effects as compared to other proteins, these observations have not been confirmed by randomized placebo-controlled trials. However, most experts recommend the consumption offoods rich in plant proteins as alternatives to meat and dairy products rich in saturated fat and containing cholesterol, according to "Dietary proteins and atherosclerosis" by Darioli R.(a)

2. Perennial allergic rhinitis (PAR)
In the study of isolated a halophilic lactic acid bacterium, Tetragenococcus halophilus Th221, from soy sauce moromi and the its effect on serum total immunoglobulin E, found that The change in serum total immunoglobulin E improved significantly at the end of the trial compared with the beginning in this group (p < 0.05). The safety of Th221 treatment was confirmed by laboratory tests and inspection of the general condition of each subject and concluded that Th221 can be expected to safely improve the symptoms of PAR, according to "Clinical efficacy of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi for perennial allergic rhinitis" by Nishimura I, Igarashi T, Enomoto T, Dake Y, Okuno Y, Obata A.(b)

3. Anti-allergic activities
In the assessment of oral supplementation of Shoyu polysaccharides (SPS) and its effective intervention for patients with perennial allergic rhinitis found that evaluation of the medication's effectiveness after 4 weeks treatment showed significant differences between the SPS- and placebo-treated groups (p<0.05). In conclusion, SPS of soy sauce improved the quality of life for patients with perennial allergic rhinitis, and soy sauce would be useful in an anti-allergic therapy utilizing everyday foods, according to "Quality of life improvement with soy sauce ingredients, Shoyu polysaccharides, in perennial allergic rhinitis: a double-blind placebo-controlled clinical study" by Kobayashi M, Matsushita H, Shioya I, Nagai M, Tsukiyama R, Saito M, Sugita T, Sugimura T, Yamamoto K.(c)

4. Breast cancer
In the analyzing of Shoyu and on the gastric mucosa of the rat found that the animals given shoyu were smaller than the controls; 15 intact rats receiving the sauce were healthy at 33 months compared with 7 controls. Only 9 of 50 operated rats lived 33 months. Breast tumors developed in 10 control rats but in none givenshoyu. The distribution of other tumors was the same,... and concluded that Shoyudid not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity. Long-term use was associated with gastric mucus loss and nuclear changes in a few rats, occasionally with a mild gastritis. according to "Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat" by MacDonald WC, Dueck JW.(4)

5. Hypolipidemic effect
In the observation of Soy sauce (Shoyu), a traditional Japanese fermented seasoning and its effect on cholesterol level found that in a 4-week randomized, double-blind, placebo-controlled parallel group study, hyperlipidemic men (TG >150 mg/dl) were treated with 600 mg of SPS (n=15) or placebo (n=15) daily. After 4 weeks, serum TG levels in the SPS-treated group were significantly (P<0.05) lower than the baseline (0 week). In conclusion, SPS of soy sauce reduce lipid absorption, and soy sauce is a potentially promising seasoning for the treatment of hyperlipidemia through food, according to "Hypolipidemic effect of Shoyupolysaccharides from soy sauce in animals and humans" by Kobayashi M, Magishi N, Matsushita H, Hashimoto T, Fujimoto M, Suzuki M, Tsuji K, Saito M, Inoue E, Yoshikawa Y, Matsuura T.(e)

6. Etc.

B. Health benefits according to concentration
1. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(1)

2. Manganese
Manganese beside plays an vital role for the proper and normal growth of human bone structure (accodring to the study of "Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants" by Pabbruwe MB,Standard OC, Sorrell CC, Howlett CR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/15109850)), it also helps to reduce the risk of cancer, (according to the study of "The effects of 3, 4 or 5 amino salicylic acids onmanganese-induced neuronal death: ER stress and mitochondrial complexes" by Yoon H, Lee GH, Kim DS, Kim KW, Kim HR, Chae HJ., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21477646 researchers indicated that the salicylate analogues and the antioxidants did not mediate ER stress in this model. The salicylate analogues reduced reactive oxygen species (ROS) and reversed the deficient mitochondrial membrane potential that was induced by Mn. Taken together, the 3, 4, 5 ASA worked in a similar way, regulating the Mn-induced mitochondrial dysfunction and protecting cells.

3. Protein
Protein beside is important building block of bones, muscles, cartilage, skin, and blood, it also enhances the nervous system in information transmitting between cells and cells of the other parts of the body, thus reducing the risk of nervous tension, (according to the study of "The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function" by Moreau MM, Piguel N, Papouin T, Koehl M, Durand CM, Rubio ME, Loll F, Richard EM, Mazzocco C, Racca C, Oliet SH, Abrous DN, Montcouquiol M, Sans N, posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20660256)

4. Niacin or vitamin B3
Niacin or vitamin B3 beside is important in production of energy in metabolism of carbohydrate, it also essential for DNA repairing, according to the study of `Niacindeficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow`by Kostecki LM, Thomas M, Linford G, Lizotte M, Toxopeus L, Bartleman AP, Kirkland JB., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17618655), production of steroid hormones in the adrenal gland, improving blood circulation and lowering the bad cholesterol (LDL) levels., according to the study of `Lowering LDL cholesterol with margarine containing plant stanol/sterol esters: is it still relevant in 2011?`by Doggrell SA., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21296266)

5. Etc.

C. Other health benefits
Since soy sauce contains high amount of sodium, a trace mineral is classified as a cause of heart diseases and stroke if eating in high amount. In fact with correct amount, soy sauce not only helps to replace the daily intake of sodium but also enhances health benefits
1. Cholesterol
Certain studies found that certain types of soy sauce (popular in Chinese cookery) have been shown to reduce the levels of bad cholesterol (LDL) because of the existence of large amounts of the isoflavones, so choose your soy sauce wisely, according to the study of `Soy isoflavones lower serum total and LDL cholesterolin humans: a meta-analysis of 11 randomized controlled trials`by Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17413118)

2. Isoflavones
Isoflavones is one of the weak estrogen that can compete with estrogen for the same receptor sites, as it decreasing the health risks of excess estrogen, promoting healthy menstrual cycle and reducing the risk of cancers caused by high levels of strong estrogen., according to the study of `Red clover and soyisoflavones-an in vitro safety assessment`by Reiter E, Gerster P, Jungbauer A., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21801124), researchers wrote that
Isoflavones and plant extracts significantly reduced the proliferation activity of the treated cancer cell lines.

3. Riboflavin
Riboflavin or vitamin B2 besides is important for the production of energy in the metabolism of fats, carbohydrates, and proteins due to its coenzymes, flavin adenine dinucleotide and Flavin mononucleotide properties, it also is the best of natural element for treating migraines and muscle pain reliever used together with magnesium, according to the study of `Effectiveness of high-dose riboflavin inmigraine prophylaxis. A randomized controlled trial`by Schoenen J, Jacquy J, Lenaerts M., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/9484373)

4. Magnesium
Magnesium beside helps to maintain the right ratio with calcium, thus aiding the digestive system in absorption of calcium, according to the study of `Associations of calcium and magnesium in serum and hair with bone mineral density in premenopausal women`by Song CH, Barrett-Connor E, Chung JH, Kim SH, Kim KS., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17848724) it also reduces the risk of irregular heart beat and impairs glucose tolerance, according to the study of `Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women`by Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17536123)

5. Etc.


Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer


Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/22139566
(b) http://www.ncbi.nlm.nih.gov/pubmed/19240374
(c) http://www.ncbi.nlm.nih.gov/pubmed/15492861
(d) http://www.ncbi.nlm.nih.gov/pubmed?term=Shoyu%20and%20breast%20cancer
(e) http://www.ncbi.nlm.nih.gov/pubmed/18813866

(1) http://www.ncbi.nlm.nih.gov/pubmed/19539268

General Health: Candida Albicans: Treatment and Controlling of Candida Albicans Overgrowth - The Effectiveness of Vitamins

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

What is Candida Albicans

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth results in candidiasis. Non-albicansCandida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candidaresistance toward antifungal agents.

Treatments and controllings

B. Vitamins
1. Vitamin B2
Vitamin B2 required for a wide variety of cellular processes, plays a key role in energy metabolism, enhances the digestive system in absorbing nutrients and supports the immune system(230)(231) in fighting against bacteria causes of inflammatory disease, including candida(232).

2. Vitamin C
Vitamin C, a water-soluble vitamin and an antioxidant found in high concentrations in immune cells, is not only important in aiding the digestive system in absorbing nutrients, but also enhances the production of white blood cell(233)(234) of the immune system(235) in protection of the body by binding to the harmful bacteria(236) and ingesting them.

3. Vitamin A
Retinoic acid, appears to maintain normal skin health by switching on genes and differentiating keratinocytes (immature skin cells)(237) into mature epidermal cells and helps to detoxify liver(238), and enhances the immune system(239)(240) in protecting our body through its antimicrobial functions, including candida albicans(241).

4. Vitamin E
Vitamin E is fat-soluble compounds included both tocopherols and tocotrienols. It besides is an polyphenol antioxidants(242)(246) in scavenging free radicals, but also promotes the immune system in enhanced functions of B-cells(244)(245), the immune cells(245)(247) in production of antibodies to destroy microorganisms.

5. Etc.


Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods LibraryEat Yourself Healthy With The Best of the Best Nature Has to Offer


References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicansisolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicansby Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistantCandida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(230) Edible mushrooms: improving human health and promoting quality life by Valverde ME1, Hernández-Pérez T1, Paredes-López O1.(PubMed)
(231) [Effect of some vitamins on activity of immunocompetent cells].[Article in Russian]by Nezgovorov DV.(PubMed)
(232) Antioxidants keep the potentially probiotic but highly oxygen-sensitive human gut bacterium Faecalibacterium prausnitzii alive at ambient air by Khan MT1, van Dijl JM1, Harmsen HJ1.(PubMed)
(233) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview by Pallotta V1, Gevi F1, D'alessandro A1, Zolla L1.(PubMed)
(234) Red blood cell metabolism under prolonged anaerobic storage by D'Alessandro A1, Gevi F, Zolla L.(PubMed)
(235) Alterations in antioxidant defense system of workers chronically exposed to arsenic, cadmium and mercury from coal flying ash by Zeneli L1, Sekovanić A, Ajvazi M, Kurti L, Daci N.(PubMed)
(236) Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C by Schoultz I1, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM.(PubMed)
(237) Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes by Meves A1, Stock SN, Beyerle A, Pittelkow MR, Peus D.(PubMed)
238. Effects of dried fish on antioxidant levels in rat liver by Anilakumar KR1, Khanum F, Krishna KR, Viswanathan KR.(PubMed)
(239) Vitamin A and retinoic acid in T cell-related immunity by Ross AC1.(PubMed)
(240) Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance by Cassani B1, Villablanca EJ, De Calisto J, Wang S, Mora JR.(PubMed)
(241) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes by Klassert TE1, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H.(PubMed)
(242) [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E].[Article in German]by Kahl R1, Kappus H.(PubMed)
(243) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(244) Immune dysfunction and cytokine production in hemodialysis. Could they be lessened by vitamin E-coated dialyzer membrane by Senatore M, Cecere P, Colombo P, Costantini L, Filiberti O, Piccini G, Peona C, Buemi M, Nicoletti A, Rizzuto G.(PubMed)
(245) Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction by Girndt M1, Lengler S, Kaul H, Sester U, Sester M, Köhler H.(PubMed)
(246) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(247) The role of vitamin E in T-cell differentiation and the decrease of cellularimmunity with aging.by Moriguchi S1.(PubMed)

Most common Diseases of 50plus: Obesity and Obesity's complication of Obesity Hypoventilation Syndrome

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Obesity hypoventilation syndrome is defined as a condition of low blood oxygen levels and high blood carbon dioxide (CO2) levels in the body of severe obese people who can not breath rapidly and deeply.

How Obesity associates with Obesity Hypoventilation Syndrome
1. In a study of "[Obesity and Sleep-related Breathing Disorders]" Luo JM, Xiao Y., posted in PubMed, researchers wrote that Obesity, with an increasing prevalence,has become one of the most common metabolic diseases. Obesity is associated with many respiratory diseases, especially sleep-related breathing disorders including obstructive sleep apnea-hypopnea syndrome, obesity hypoventilation syndrome, and overlap syndrome. This article reviews the association between obesity and these sleep-related breathing disorders.

2. According to a study of "The pickwickian syndrome-obesity hypoventilation syndrome" by Littleton SW, Mokhlesi B., posted in PubMed, researchers wrote that Obesity-hypoventilation syndrome (OHS), also historically described as the Pickwickian syndrome, consists of the triad of obesity, sleep disordered breathing, and chronic hypercapnia during wakefulness in the absence of other known causes of hypercapnia. Its exact prevalence is unknown, but it has been estimated that 10% to 20% of obese patients with obstructive sleep apnea have hypercapnia

3. In the abstract of the study of "Respiratory complications of obesity" [Article in English, Spanish] by Rabec C, de Lucas Ramos P, Veale D., posted in PubMed, researchers indicated that Obesity, well known as a cardiovascular risk factor, can also lead to significant respiratory complications. The respiratory changes associated with obesity extend from a simple change in respiratory function, with no effect on gas exchange, to the more serious condition of hypercapnic respiratory failure, characteristic of obesity hypoventilation syndrome. More recently, it has been reported that there is an increased prevalence of asthma which is probably multifactorial in origin, but in which inflammation may play an important role.

4. In a study of "Influence of body mass index on treatment of breathing-related sleep disorders" by Dzieciolowska-Baran E, Gawlikowska-Sroka A, Poziomkotska-Gesicka I, Teul-Swiniarska I, Sroczynski T., posted in PubMed, researchers found that the analysis demonstrated a significant influence of body mass on snoring, particularly in complicated and severe types of breathing disorders, such obstructive sleep apnea or hypopnea, and the obesity hypoventilation syndrome. Corrective interventions carried out to eliminate anatomical abnormalities causing obstruction of upper airways provided the best therapeutic effects in patients with normal body mass.

5. According to the study of "Sleep-related breathing disorders, loud snoring and excessive daytime sleepiness in obese subjects" by Resta O, Foschino-Barbaro MP, Legari G, Talamo S, Bonfitto P, Palumbo A, Minenna A, Giorgino R, De Pergola G., posted in PubMed, researchers concluded that OSA is present in more than 50% of a population of obese patients with a mean BMI higher than 40.0, this percentage being much higher than that commonly reported in previous studies, particularly in women. Neck circumference in men and BMI in women seem to be the strongest predictors of the severity of OSA in obese patients. Nocturnal hypoventilation seems to be present in more than 29% of a severe obese population. Moreover, this study indicates that morbid obesity can be associated with excessive daytime sleepiness even in the absence of sleep apnea.

6. Etc.

Treatments of Obesity and Obesity Hypoventilation Syndrome
1. According to the study of "Noninvasive Ventilation in Mild obesity hypoventilation syndrome: A randomized controlled trial" by Borel JC, Tamisier R, Gonzalez-Bermejo J, Baguet JP, Monneret D, Arnol N, Roux-Lombard P, Wuyam B, Levy P, Pepin JL, posted in PubMed, researchers found that NIV group patients (n=18) were older (58±11 versus 54±6 years) with a higher baseline PaCO(2) (47.9±4.2 versus 45.2±3 mmHg). In intention to treat analysis, compared to control group, NIV significantly reduced daytime PaCO(2) (difference between treatments: -3.5 mmHg; 95%CI:-6.2 to -0.8) and apnea-hypopnea-index (-40.3/h 95%CI:-62.4 to -18.2). Sleep architecture was restored although non-respiratory micro-arousals increased (+9.4/hour of sleep; 95%CI: 1.9 to 16.9) and daytime sleepiness was not completely normalized. Despite a dramatic improvement in sleep hypoxemia, glucidic and lipidic metabolism parameters as well as cytokines profiles did not vary significantly. Accordingly, neither RH-PAT (+0.02; 95%CI: -0.24 to 0.29) nor arterial stiffness (+0.22m.s(-1); 95%CI: -1.47 to 1.92) improved.

2. According to the study of "Obesity hypoventilation syndrome" by Al Dabal L, Bahammam AS., posted in PubMed, researchers indicated that Despite its major impact on health, this disorder is under-recognized and under-diagnosed. Available management options include aggressive weight reduction, oxygen therapy and using positive airway pressure techniques. In this review, we will go over the epidemiology, pathophysiology, presentation and diagnosis and management of OHS.

3. In the abstract of the study of "Diagnosis and management of obesity hypoventilation syndrome in the ICU" by Lee WY, Mokhlesi B., posted inPubMed, researchers concluded that Because of the global obesity epidemic and the high prevalence of obstructive sleep apnea in the general population, critical care physicians are likely to encounter patients who have acute-on-chronic respiratory failure attributable to OHS in their clinical practice. In this article we define the clinical characteristics of OHS, review its pathophysiology, and discuss the morbidity and mortality associated with OHS. Finally, we offer treatment strategies during ICU management using noninvasive positive pressure ventilation that may guide the physician in the care of these challenging patients.
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Monday, May 30, 2016

Food therapy - Whole wheat (Triticum)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                Whole wheat


Wheat is a type of glass originally from the Middle East, but now cultivated worldwide for commercial purposes. In its natural unrefined state, it contains many important nutrients that can help nourish the healthy body and enhances fertility in men and women alike.


Nutrients
1. Carbohydrates
2. Dietary fiber
3. Protein
4. Vitamin B Complex
5. Tryptophan
6. Calcium
7. Iron
8. Magnesium
9. Manganese
10. Phosphorus
11. Potassium
12. Zinc
13. Etc.

Heath Benefits
A. Health benefits according to studies
1. Hyperglycemic/hyperinsulinemic effects
In the assessment to the effects of 6-week consumption of whole grain wheatsourdough bread in comparison to white bread on fasting serum lipids in normoglycemic/normoinsulinemic (NGI; n = 14) and hyperglycemic/hyperinsulinemic (HGI; n = 14) adults, found that add to limited literature comparing wheat whole grains to wheat refined grains on CVD risk and highlight the need to consider genetic variation in relation to lipoprotein lipid content and CVD risk, according to "The effect of whole grain wheat sourdough bread consumption on serum lipids in healthy normoglycemic/normoinsulinemic and hyperglycemic/hyperinsulinemic adults depends on presence of the APOE E3/E3 genotype: a randomized controlled trial" by Tucker AJ, Mackay KA, Robinson LE, Graham TE, Bakovic M, Duncan AM.(a)

2. Prostate cancer progression
In the investigation of rye whole grain and bran products (RP) or refined wheatproducts with added cellulose (WP) and theirs effect on pregression of prostate cancer found that Daily excretion of 5 lignans was higher after the RP treatment than after the WP treatment (P < 0.001). We conclude that whole grain and bran from rye resulted in significantly lower plasma PSA compared with a cellulose-supplemented refined wheat diet in patients with prostate cancer. The effect may be related to inhibition of prostate cancer progression caused by decreased exposure to insulin, as indicated by plasma insulin and urinary C-peptide excretion, according to "Rye whole grain and bran intake compared with refined wheatdecreases urinary C-peptide, plasma insulin, and prostate specific antigen in men with prostate cancer" by Landberg R, Andersson SO, Zhang JX, Johansson JE, Stenman UH, Adlercreutz H, Kamal-Eldin A, Aman P, Hallmans G.(b)

3. Antioxidants
In the classification of Anthocyanins of whole purple wheat, unpolished red rice, and partially polished red rice before and after processing to produce infant cereals and it antioxidant efect found that purple wheat infant cereals had higher cellular antioxidant activity than unpolished red rice ones (p < 0.05). Whole purple wheatinfant cereals showed higher antioxidant activity than the commercial infant cereal, suggesting a possibility of improving infant antioxidant status by incorporating this grain in their diet, according to "Comparative Evaluation of the Antioxidant Potential of Infant Cereals Produced from Purple Wheat and Red Rice Grains and LC-MS Analysis of Their Anthocyanins" by Hirawan R, Diehl-Jones W, Beta T.(c)

4. Glucose and Lipid metabolism
In the observation of Whole grain products, fish and bilberries and theirs effect on Glucose and Lipid metabolism found that the diet rich in whole grain and low insulin response grain products, bilberries, and fatty fish improve glucose metabolism and alter the lipidomic profile. Therefore, such a diet may have a beneficial effect in the efforts to prevent type 2 diabetes in high risk persons, according to "Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study" byLankinen M, Schwab U, Kolehmainen M, Paananen J, Poutanen K, Mykkänen H, Seppänen-Laakso T, Gylling H, Uusitupa M, Orešič M.(d)

5. Etc.

B. Health benefits according to concentration
1. Manganese
It is one of important trace in preventing osteroposis, according to the study of "[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]" by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(4)and regulating blood sugar level, according to the study of "[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]" by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(I)

2. Dietary fiber
Since it contains high levels of fiber, it reduces the risk of type II diabetes and insulin sensitive, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F., posted in PubMed(II)

3. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(III)

4. Magnesium
Magnesium not only important for bone health, according to the study of "Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis?" by Odabasi E, Turan M, Aydin A, Akay C, Kutlu M(6) but also play and important role in protecting against Alzheimer's disease, according to the study of "Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease" by Barbagallo M, Belvedere M, Di Bella G, Dominguez LJ.(IV)

5. Etc.

C. Other health benefits
1. Weight control and body organs
Since whole wheat in its natural state, it contains high amount of fiber that can reduce the fluctuation of insulin and the risk of depress of pancreas that can increase appetite and weigh gain., according to the study of "The effect of usingwhole wheat grain in the diet of game pheasants on their body weight, dimensions and development of some internal organs" by Kokoszyński D, Bernacki Z, Cisowska A., posted in PubMed(1).


2. Diabetes
Since fiber also reduces the risk of insulin sensitive by releasing sugar slowly in to blood stream, thus decreasing the risk of type II diabetes, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F., posted pubMed(2).

3. High blood pressure, heart disease and stroke
As we mention in the previous article, high levels of magnesium reduces the risk of blood clot by dilating blood vessels, according to the study of "Magnesiumcauses nitric oxide independent coronary artery vasodilation in humans" by Teragawa H, Kato M, Yamagata T, Matsuura H, Kajiyama G., posted in PubMed(3), thus decreasing the risk of high blood pressure, heart disease and stroke.

4. Cholesterol Levels
Whole wheat contains plant sterols and stanols which are proven to be effective in slowing the progression of atherosclerosis by reserving atherosclerosis naturally caused by cholesterol builds up the plaques inside the arteries, leading arteries clogged, resulting in cardiovascular diseases, according to the study of "New insights into the molecular actions of plant sterols and stanols in cholesterolmetabolism" by Calpe-Berdiel L, Escolà-Gil JC, Blanco-Vaca F., posted in PubMed(4).
5. Breast cancer
High levels of lignan in whole wheat acts as antioxidant that improves the immune function in fighting against irregular cell growth, thus reducing the risk of cancer, according to the study of " Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis"byAgarwal RP, Grusch M, Hidvégi M, Jaeger W, Krupitza G, Lackner A, Madlener S, Ozsvar-Kozma M, Saiko P, Szekeres T, Fritzer-Szekeres M, Graser G posted in Journal: Oncology Reports Release date: 2009 (5), researchers found that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies.

6. Etc.

Side effects
1. Gliadin in whole wheat can weaken the immune system, leading to inflammation.
2. Wheat allergy.
3. Oxalates

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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/20444273
(b) http://www.ncbi.nlm.nih.gov/pubmed/20980650
(c) http://www.ncbi.nlm.nih.gov/pubmed/22035073
(d) http://www.ncbi.nlm.nih.gov/pubmed/21901116

(I) http://www.ncbi.nlm.nih.gov/pubmed/22072339
(II) http://www.ncbi.nlm.nih.gov/pubmed/20713332
(III) http://www.ncbi.nlm.nih.gov/pubmed/19539268
(IV) http://www.ncbi.nlm.nih.gov/pubmed/21951617

1. http://www.ncbi.nlm.nih.gov/pubmed/20420203
2. http://www.ncbi.nlm.nih.gov/pubmed/20713332
3. http://www.ncbi.nlm.nih.gov/pubmed/114548464.http://www.ncbi.nlm.nih.gov/pubmed/18692849
5. http://www.avemar.com/for_medical_professionals/48

General Health: Candida Albicans: Treatment and Controlling of Candida Albicans Overgrowth - The. Effectiveness of Diet

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

What is Candida Albicans

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth results in candidiasis. Non-albicansCandida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candidaresistance toward antifungal agents.


Treatments and controlling

A. Diet
1. Apple Cider Vinegar
Apple Cider Vinegar is a type of vinegar made from cider or apple must and has a pale to medium amber color. Beside it is known for treating obesity(208)(209), rich in natural enzymes which aid in digestion, Apple cider vinegar also balances your body's pH level, Its high amount of antioxidants, help to restore the natural balance of healthy bacteria in the gut by creating a perfect environment for those healthy bacteria to grow, all while keeping candida in check(207) by enhancing the immune function(210) in regulating the microorganism in the body.

2. Coconut oil
Coconut oil is extracted from the kernel or meat of matured coconut harvested from the coconut palm tree, native to the tropical world. Coconut oil, is one of most effective antibacterial(including Candida)(211)(213), antioxidant(214), antiviral(215) agents, used in traditional medicinal remedies for treatment of benign prostatic hyperplasia(216) and inflammation(217). Caprylic acid, a minor constituent of coconut oil has been demonstrated to inhibit fungal growth(212)(218), both topically and internally.

3. Garlic
Garlic is species of Allium sativum, belong to the family Alliaceae, used as both food and medicine in many cultures for thousands of years. Garlic cloves are used as a remedy for infections(219)(220), digestive disorders(221), and fungal infections, including candida(222), due to large number of anti-fungal properties of sulphur, allicin, alliin, alliinase and S-allylcysteine.

4. Ginger
Ginger is a species of Zingiber officinale, belong to the family Zingiberaceae, used in as a delicacy, medicine, or spice in many cultures. The gingerrols in ginger increase the motility of the gastrointestinal tract(223) and as analgesic(224)(226), sedative(225), antipyretic(226), antibacterial(227) and anti- inflammatory(228) properties. Reseacher (Am. J. Applied Sci., 6 (6): 1067-1069, 2009) found that ginger extract containing gingerol inhibits the growth of many bacteria and fungi, including candida ablicans(229).

5. Etc.


Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

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Holistic System In Existence That Will Show You How To
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 References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicansisolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicansby Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistantCandida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(208) 7 Health Benefits of Apple Cider VinegarMichelle Schoffro CookSeptember 4, 20146:11 pm200 (Care 2)
(209) Changes in anthropometric measurements, body composition, blood pressure, lipid profile, and testosterone in patients participating in a low-energy dietary intervention by Balliett M1, Burke JR.(PubMed)
(210) Apple Cider Vinegar Recipes(Immunology)
(211) Antimicrobial effects of virgin coconut oil and its medium-chain fatty acids on Clostridium difficile by Shilling M1, Matt L, Rubin E, Visitacion MP, Haller NA, Grey SF, Woolverton CJ.(PubMed)
(212) Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms by Huang CB1, Alimova Y, Myers TM, Ebersole JL.(PubMed)
(213) Activity of virgin coconut oil, lauric acid or monolaurin in combination with lactic acid against Staphylococcus aureus by Tangwatcharin P1, Khopaibool P.(PubMed)
(214) Antioxidant capacity and phenolic acids of virgin coconut oil by Marina AM1, Man YB, Nazimah SA, Amin I.(PubMed)
(215) Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention by DebMandal M1, Mandal S.(PubMed)
(216) Effects of coconut oil on testosterone-induced prostatic hyperplasia in Sprague-Dawley rats by de Lourdes Arruzazabala M1, Molina V, Más R, Carbajal D, Marrero D, González V, Rodríguez E.(PubMed)
(217) Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil by Intahphuak S1, Khonsung P, Panthong A.(PubMed)
(218) Caprylic Acid and glyceryl trinitrate combination for eradication of biofilm by Rosenblatt J1, Reitzel RA2, Raad I2.(PubMed)
(219) Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infectionsby Bjarnsholt T1, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, Hougen HP, Rygaard J, Moser C, Eberl L, Høiby N, Givskov M.(PubMed)
(220) An in vitro assessment of the antibacterial effect of garlic (Allium sativum) on bacterial isolates from wound infectionsby Tessema B1, Mulu A, Kassu A, Yismaw G.(PubMed)
(221) Antileishmanial activity of a mixture of Tridax procumbens and Allium sativum in mice by Gamboa-Leon R1, Vera-Ku M1, Peraza-Sanchez SR2, Ku-Chulim C1, Horta-Baas A1, Rosado-Vallado M1.(PubMed)
(222) The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double-blind trialby Watson CJ1, Grando D, Fairley CK, Chondros P, Garland SM, Myers SP, Pirotta M.(PubMed)
(223) Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptorsby Pertz HH1, Lehmann J, Roth-Ehrang R, Elz S.(PubMed)
(224) Ginger (Zingiber officinale Roscoe) prevents the development of morphineanalgesic tolerance and physical dependence in ratsby Darvishzadeh-Mahani F1, Esmaeili-Mahani S, Komeili G, Sheibani V, Zare L.(PubMed)
(225) Stimulative and sedative effects of essential oils upon inhalation in mice.by Lim WC1, Seo JM, Lee CI, Pyo HB, Lee BC.(PubMed)
(226) Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a reviewby Pereira MM1, Haniadka R, Chacko PP, Palatty PL, Baliga MS.(PubMed)
(227) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from gingerrhizome against periodontal bacteriaby Park M1, Bae J, Lee DS.(PubMed)
(228) Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in miceby Shieh YH1, Huang HM2, Wang CC3, Lee CC4, Fan CK5, Lee YL6.(PubMed)
(229) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceaeby Takahashi M1, Inouye S, Abe S.(PubMed)

Phytochemicals In Foods: The effects of Betaxanthins

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                         Betaxanthins 

Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments , belonging to the group of Betalains, found abundantly in beets, sicilian prickly pear, etc.

Health Benefits
1. Fatty Liver diseases
In the investigation of the protective effects of bioactive agents of the liophylised table beet and carrot powder on fatty liver in a "short term" experiment, found that the higher dose of the natural product better decreased the induced free radical reactions, cyclooxygenase-2, inducible nitric oxide synthase and tumor necrosis factor-α mRNA-levels both in normal and fatty liver tissues. Although treatments failed to exert significant changes in all global antioxidant parameters, mobilized methyl group concentrations were higher after treatments in fatty liver. Favorable tendencies were also noted in the redox-homeostasis of the fatty liver after treatment, according to "[Experimental food-induced fatty liver and its adjuvant therapy with natural bioactive substances].[Article in Hungarian]" by Hegedüs V, Gerö D, Mihály Z, Szijártó A, Zelles T, Sárdi E.(1)

2. Free Radical-Scavenging Activities
In the determination of betalamic acid, the chromophore of betaxanthins, was enzymatically synthesized on a large scale from l-dihydroxyphenylalanine (L-DOPA) using recombinant Mirabilis jalapa DOPA 4,5-dioxygenase for its Radical-Scavenging Activities, suggested that GABA-betaxanthin showed comparatively low activity, whereas dopamine-betaxanthin had similar activity to the red pigment betanin and the anthocyanin cyanidin 3-glucoside. Proline-betaxanthin had the highest activity of the three synthesized compounds and was similar to the flavonoid quercetin, according to "In Vitro Synthesis of Betaxanthins Using Recombinant DOPA 4,5-Dioxygenase and Evaluation of Their Radical-Scavenging Activities" by Sekiguchi H, Ozeki Y, Sasaki N.(2)

3. Antispasmodic effects
In the investigation, the effects of a hydrophilic extract from Opuntia ficus indica fruit pulp (cactus fruit extract, CFE) on the motility of mouse ileum, using an organ bath technique, and researched the extract component(s) responsible for the observed responses, showed that CFE is able to exert direct antispasmodic effects on the intestinal motility. The CFE inhibitory effects do not involve potassium channels or voltage-dependent calcium channels but rather pathways of calcium intracellular release. The fruit pigment indicaxanthin appears to be the main component responsible for the CFE-induced effects, acording to "Inhibition of the mechanical activity of mouse ileum by cactus pear (Opuntia Ficus Indica, L, Mill.) fruit extract and its pigment indicaxanthin" by Baldassano S, Tesoriere L, Rotondo A, Serio R, Livrea MA, Mulè F.(3)

4. Intestinal contractility
In the investigation of pasmolytic effects on the intestinal contractility in vitro isndicaxanthin, the yellow betalain pigment abundant in the fruit of Opuntia ficus indica, for the mechanism of action underlying the observed response, found that Indicaxanthin and IBMX significantly reduced the carbachol-evoked contractions and the joint application of both drugs did not produce any additive effect. Indicaxanthin and IBMX increased the inhibitory effects of forskolin, an adenylyl cyclase activator, and the joint application of both drugs did not produce any additive effect. Indicaxanthin, contrarily to IBMX, did not affect the inhibitory action of sodium nitroprusside, a soluble guanylyl cyclase activator. Indicaxanthin increased both basal and forskolin-induced cAMP content of mouse ileal muscle. The present data show that indicaxanthin reduces the contractility of ileal longitudinal muscle by inhibition of PDEs and increase of cAMP concentration and raise the possibility of using indicaxanthin in the treatment of motility disorders, such as abdominal cramps, according to "Inhibitory effects of indicaxanthin on mouse ileal contractility: analysis of the mechanism of action" by Baldassano S, Rotondo A, Serio R, Livrea MA, Tesoriere L, Mulè F.(4)

5. Anti cancers
In the investigation of juices of nine prickly pears (Opuntia spp.) were characterized in terms of color, acidity, sugar content, phenolics, flavonoids, betalains and antioxidant activity and tested in vitro against four cancer cell lines, found that among the cancer lines tested, viability of prostate and colon cells were the most affected. Moradillo contained the highest flavonoids and diminished both prostate and colon cancer cell viability without affecting mammary or hepatic cancer cells. Rastrero reduced the growth of the four cancer cell lines without affecting normal fibroblast viability. The research shows intervarietal differences among prickly pears in terms of juice properties and phytochemicals that could prevent oxidative stress and cancer, according to 'Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices" by Chavez-Santoscoy RA, Gutierrez-Uribe JA, Serna-Saldívar SO.(5)

6. Myeloperoxidase and hypochlorous acid
In the evaluation of Hypochlorous acid (HOCl), the most powerful oxidant produced by human neutrophils and contribution to the damage caused by these inflammatory cells, produced from H2O2 and chloride by the heme enzyme myeloperoxidase (MPO), found that at pH 7.0 and 25 degrees C. Formation of ferric (native) MPO from compound II occurs with a second-order rate constant of (1.1+/-0.1) x 10(5) M(-1) s(-1) (betanin) and (2.9+/-0.1) x 10(5) M(-1) s(-1) (indicaxanthin), respectively. In addition, both betalains can effectively scavenge hypochlorous acid with determined rates of (1.8+/-0.2) x 10(4) M(-1) s(-1) (betanin) and (7.7+/-0.1) x 10(4) M(-1) s(-1) (indicaxanthin) at pH 7.0 and 25 degrees C., according to "Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid" by Allegra M, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C.(6).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21652297
(2) http://www.ncbi.nlm.nih.gov/pubmed/21058725
(3) http://www.ncbi.nlm.nih.gov/pubmed/20518499
(4) http://www.ncbi.nlm.nih.gov/pubmed/21371457
(5) http://www.ncbi.nlm.nih.gov/pubmed/19468836
(6) http://www.ncbi.nlm.nih.gov/pubmed/15913556