Ginger may be next generation whole food used for the prevention and treatment of type 2 diabetes, with no side effects, some scientists suggested.
Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.
Researchers do not know what causes the pancreas dying off or receptor sites clogged up. However, they do know obesity or overweight, gender, ethnicity, age, family history, gestation diabetes, are associated with an increased risk of type 2 diabetes.
Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.
Most common symptoms of type 2 diabetes are an increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.
If you experience some of the symptoms above, please make you check with your doctor to rule out the possibility of diabetes.
According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
Dr. Rita R. Kalyani in the study to examine the increase with age and risk of type 2 diabetes wrote, "The unprecedented aging of the world's population is a major contributor to the diabetes epidemic, and older adults represent one of the fastest growing segments of the diabetes population".
"Almost one-third of U.S. adults over the age of 65 years have diabetes. Approximately half of those are undiagnosed, and an additional one-third of older adults have prediabetes" and "management of older adults with diabetes is clearly more complicated given the observation that they commonly have multiple coexisting medical conditions that can impact clinical management".
Compared to the general population risk of type 2 diabetes, the results clearly stated, the risk of type diabetes in elderly is 3 fold higher and the management of the disease is more difficult due accompanied by other medical conditions, such as high blood pressure and cholesterol
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food for the prevention and treatment of diabetes with little or no side effects, researchers looked into the effects of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial, included 70 type 2 diabetic patients allocated randomly into ginger group consumed 1600 mg ginger and control group consumed 1600 mg wheat flour daily for 12 weeks.
Patients treated with ginger demonstrated a significant effect in reducing the levels of fasting plasma glucose, 3 months average glucose concentration, insulin resistance.
Furthermore, the blood profile of treatment group also displayed lower levels of triglyceride, total cholesterol, a hormone associated with lipid peroxidation. compared to the placebo group.
There were no significant differences in high-density lipoprotein (HDL), low-density lipoprotein LDL, and TNFα, the inflammatory cytokine between two groups.
The findings firmly indicated ginger improves insulin sensitivity and some fractions of lipid profiles and reduced inflammation in type 2 diabetic patients.
Additionally, with an aim to reaffirm the effects of ginger against the development of type 2 diabetes and diabetic complications, researchers investigated the effect of ginger supplementation on glycemic indices in Iranian patients with type 2 diabetes.
The double-blind, placebo-controlled, randomized clinical trial included 20-60 -year-old patients with type 2 diabetes who did not receive insulin.
Participants in the intervention and control groups were received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months.
At the end of the 3 months, researchers showed that all parameters associated diabetes were reduced substantially in the treatment group compared to control.
More precisely, the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (-19.41 ± 18.83 vs. 1.63 ± 4.28 mg/dL, p < 0.001), (Hemoglobin A1C)HbA1c percentage (-0.77 ± 0.88 vs. 0.02 ± 0.16%, p < 0.001), insulin (-1.46 ± 1.7 vs. 0.09 ± 0.34 μIU/mL, p < 0.001), insulin resistance (-16.38 ± 19.2 vs. 0.68 ± 2.7, p < 0.001), high-sensitive CRP (-2.78 ± 4.07 vs. 0.2 ± 0.77 mg/L, p < 0.001), paraoxonase-1 (PON-1) (22.04 ± 24.53 vs. 1.71 ± 2.72 U/L, p < 0.006), total antioxidant capacity (TAC) (0.78 ± 0.71 vs. -0.04 ± 0.29 µIU/mL, p < 0.01) and MDA (-0.85 ± 1.08 vs. 0.06 ± 0.08 µmol/L, p < 0.001) were significantly different.
Where paraoxonase ((PON)-1 is an enzyme associated with the protection against lipid oxidation, Malondialdehyde (MDA) is an oxidative stress marker.
Dr. Shidfar F, the lead scientist said, " the 3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes".
Taken altogether, ginger may be considered a functional food for the prevention and combined with the primary therapy for the treatment of type 2 diabetes with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients by Mahluji S1, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. (PubMed)
(3) The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes by Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. (PubMed)
(4) Diabetes and Aging: Unique Considerations and Goals of Care, Rita R. Kalyani, Sherita H. Golden and William T. Cefalu. (Diabetes Care)
Saturday, March 23, 2019
Thyme Honey, the Potential Anti Endometrial Cancer Functional Food
Honey may have a significant effect on reducing risk and treatment of endometrial cancer, some scientists suggested.
Endometrial cancer is a chronic condition characterized by the irregular cell in the tissue of the endometrium.
Most cases of endometrial cancer start on the cells in the surface of the inner lining of the endometrium. At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissue and organs.
Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.
The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity and use of hormone therapy are some the major prevalent risk factors associated with endometrial cancer.
Some researchers indicated that hormone change in the women body such as higher androgen and estrogen levels and lower levels of progesterone due to polycystic ovarian syndrome (PCOs) also is a major cause of endometrial cancer.
Dr. Navaratnarajah R, the lead author in the concern of the association of polycystic ovarian syndrome (PCOs) and the risk endometrial cancer, said, "several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk".
"The mechanism(s) underlying any association is also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor".
These result clearly state that long-term overexpression of estrogen and reduced levels of progesterone are associated with the onset of the diseases. However, the study of PCOs in the endometrial cancer risk should also be taken into accounts of obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS and risk factors for endometrial carcinoma.
In the association of PCOs and endometrial cancer mortality, the doctor team indicated, there is no evidence to link the increased mortality from endometrial cancer in women with the syndrome.
The study once again reaffirms the link of the estrogen therapy used in menopause women for the treatment of climate symptoms. In other words, long-term high levels of estrogen compared to progesterone in the body is the major cause of endometrial cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the prevention and treatment of endometrial cancer, researchers examined the honey influence the oestrogenic activity.
The chemical composition and the potential of Greek honey extracts (thyme, pine and fir honey) were classified to evaluate the most inhibitory activity against the endometrial cancer cells Ishikawa line.
Compared to other honey, thyme honey processes the highest total phenolics, phenolic acids, and hydroxymethylfurfural.
Thyme honey inhibited the expression of Ishikawa by reducing the cancer cells viability.
Moreover, application of thyme honey also exerted a significant effect against Ishikawa and other cancer cell lines by inhibiting the cancer cell proliferation, inducing apoptosis and cell cycle arrest.
Futhermore, the inhibition of Thyme honey also found to associated with its function in the mediation of estrogen via modulation of the estrogen receptor activity, as estrogen agonists or antagonists in cancer cell lines on a tissue type-specific manner.
The efficacy of thyme honey anti endometrial cancer was probably associated with its polyphenols and phenolic acids (vanillic acid and protocatechuic acid and p10 hydroxybenzoic acid) as these compounds have been proven to inhibit cancer-related pathways and processes
These results indicated that thyme honey monitored cell proliferation may be useful in cancer prevention, particularly, in endometrial cancer, though it's agonists/antagonists properties.
Dr. Mari Jaakkola, the lead scientist in the conclusion of the study said, " honey, especially the thyme honey, may be used as an alternative to sugar, while its incorporation in the human diet or as a food ingredient may prevent cancer-related processes, promoting thus the health of consumers".
Taken altogether, Thyme honey processed major bioactive compounds polyphenols and phenolic acids may be considered a functional food for the prevention and combined with other primary therapy for the treatment of endometrial cancer without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Bioactivity of Greek honey extracts on breast cancer (MCF7), prostate cancer (PC3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts (Research Gate) PDF
(2) Polycystic ovary syndrome and endometrial cancer by Navaratnarajah R1, Pillay OC, Hardiman P. (PubMed)
Endometrial cancer is a chronic condition characterized by the irregular cell in the tissue of the endometrium.
Most cases of endometrial cancer start on the cells in the surface of the inner lining of the endometrium. At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissue and organs.
Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.
The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity and use of hormone therapy are some the major prevalent risk factors associated with endometrial cancer.
Some researchers indicated that hormone change in the women body such as higher androgen and estrogen levels and lower levels of progesterone due to polycystic ovarian syndrome (PCOs) also is a major cause of endometrial cancer.
Dr. Navaratnarajah R, the lead author in the concern of the association of polycystic ovarian syndrome (PCOs) and the risk endometrial cancer, said, "several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk".
"The mechanism(s) underlying any association is also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor".
These result clearly state that long-term overexpression of estrogen and reduced levels of progesterone are associated with the onset of the diseases. However, the study of PCOs in the endometrial cancer risk should also be taken into accounts of obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS and risk factors for endometrial carcinoma.
In the association of PCOs and endometrial cancer mortality, the doctor team indicated, there is no evidence to link the increased mortality from endometrial cancer in women with the syndrome.
The study once again reaffirms the link of the estrogen therapy used in menopause women for the treatment of climate symptoms. In other words, long-term high levels of estrogen compared to progesterone in the body is the major cause of endometrial cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the prevention and treatment of endometrial cancer, researchers examined the honey influence the oestrogenic activity.
The chemical composition and the potential of Greek honey extracts (thyme, pine and fir honey) were classified to evaluate the most inhibitory activity against the endometrial cancer cells Ishikawa line.
Compared to other honey, thyme honey processes the highest total phenolics, phenolic acids, and hydroxymethylfurfural.
Thyme honey inhibited the expression of Ishikawa by reducing the cancer cells viability.
Moreover, application of thyme honey also exerted a significant effect against Ishikawa and other cancer cell lines by inhibiting the cancer cell proliferation, inducing apoptosis and cell cycle arrest.
Futhermore, the inhibition of Thyme honey also found to associated with its function in the mediation of estrogen via modulation of the estrogen receptor activity, as estrogen agonists or antagonists in cancer cell lines on a tissue type-specific manner.
The efficacy of thyme honey anti endometrial cancer was probably associated with its polyphenols and phenolic acids (vanillic acid and protocatechuic acid and p10 hydroxybenzoic acid) as these compounds have been proven to inhibit cancer-related pathways and processes
These results indicated that thyme honey monitored cell proliferation may be useful in cancer prevention, particularly, in endometrial cancer, though it's agonists/antagonists properties.
Dr. Mari Jaakkola, the lead scientist in the conclusion of the study said, " honey, especially the thyme honey, may be used as an alternative to sugar, while its incorporation in the human diet or as a food ingredient may prevent cancer-related processes, promoting thus the health of consumers".
Taken altogether, Thyme honey processed major bioactive compounds polyphenols and phenolic acids may be considered a functional food for the prevention and combined with other primary therapy for the treatment of endometrial cancer without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Bioactivity of Greek honey extracts on breast cancer (MCF7), prostate cancer (PC3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts (Research Gate) PDF
(2) Polycystic ovary syndrome and endometrial cancer by Navaratnarajah R1, Pillay OC, Hardiman P. (PubMed)
Friday, March 22, 2019
Artichoke Kills Leukemic Cells Before They Can Spread, According to Studies
Artichoke may have a positive and profound effect in reducing risk and treatment of leukemia with no side effects, according to studies.
Leukemia is a medical condition arisen from the abnormal white blood cells produced by the bone marrow.
There are several forms of leukemia, including acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).
CLL and AML are the most common cancers in adults and ALL are most common in children.
Contrast to chronic leukemias that take months or years to develop, acute leukemias start and develop within days or weeks.
According to Leukemia Research, Leukemia causes the death of approximately 68,000 every year. Adults are 10 times more likely to develop the disease, compared to children.
And, Non-Hodgkin's lymphoma is the 7th most common cancer in the U.S. The 5-year survival rate for all subtypes of leukemia is 61.4 percent.
Certain types of blood disorder, exposure to radioactive substances, and certain medication are some of the prevalent risks of cancer.
Some researchers suggested that cigarette smoking may contribute to the large part of AML onset compared to other subtypes.
Dr. Fircanis S in the study of "The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies" wrote in the final report, "current and ever smokers have 40% (RR 1.40, 95% CI 1.22-1.60; P < 0.001) and 25% (RR 1.25, 95% CI 1.15-1.36; P < 0.001) increased risk of developing AML when compared with non-smokers".
And, "Intensity of smoking of <10, 10-20, 20-30, and >30 cigarettes per day was associated with RRs of AML of 1.27, 1.36, 1.55, and 1.77, respectively (P < 0.001 for trend). Duration of smoking of <20 and >20 years was associated with RRs of 1.07 and 1.44, respectively (P < 0.001 for trend). Cumulative smoking of <10, 10-20, 20-30, and >30 pack-years was associated with RRs of 1.13, 1.23, 1.39, and 1.71, respectively (P < 0.001 for trend)".
The results strongly suggested that cigarette smoking is a major risk factor of acute myeloid leukemia and the risk of AML is increased depending on how many cigarettes that a person smokes a day.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural whole food for the treatment of leukemia against the overexpression of proinflammatory cytokines investigated the extract and 3 participating compounds of artichoke leaves (bracts on the human leukemia cell line.
Injection of the artichoke extract and compounds showed to modulate the lipopolysaccharide (LPS)-induced activation of proinflammatory protein (NF-κB) and the intracellular proinflammatory reactive oxygen species.
Low concentrations of the extract inhibited the enzyme AKR1B1 associated with the activation of NF-κB and the expression of pro-inflammatory genes.
The efficacy of the extract in the attenuation of the expression of the inflammation-related enzymes COX-2 and MMP-2 was attributed to the inhibiting activity of NF-κB.
In other words, artichoke reduced the production of inflammatory cytokines by inhibiting the levels of intracellular reactive oxygen species in activation of the protein NF-κB.
By suppressing the enzyme AKR1B1, artichoke reduced the inflammatory expression in facilitating the onset of leukemia.
Furthermore, in order to reveal more information about artichoke extract (CCE) against leukemia researchers evaluated the CCE effect on the growth of L1210 and HL-60 leukemia cells.
Injection with a variety of concentrations of CCE (500-2500 microg/microL) for 24 h resulted in dose-dependent inhibition of leukemia cell growth observed by the cell cycle arrest in S phase.
CCE also induced apoptosis of leukemia cells, detected by the sub-G(0) cell population and apoptotic DNA fragmentation.
The findings suggested that CCE inhibits leukemia cells through several mechanisms including the proteins associated with cell cycle division, inflammation, and cell degradation.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of leukemia, pending to the result of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells by Miláčková I1, Kapustová K1, Mučaji P1, Hošek J. (PubMed)
(2) Growth inhibitory effect of ethyl acetate-soluble fraction of Cynara cardunculus L. in leukemia cells involves cell cycle arrest, cytochrome c release and activation of caspases by Nadova S1, Miadokova E, Mucaji P, Grancai D, Cipak L. (PubMed)
(3) The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies by Fircanis S1, Merriam P, Khan N, Castillo JJ. (PubMed)
Leukemia is a medical condition arisen from the abnormal white blood cells produced by the bone marrow.
There are several forms of leukemia, including acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).
CLL and AML are the most common cancers in adults and ALL are most common in children.
Contrast to chronic leukemias that take months or years to develop, acute leukemias start and develop within days or weeks.
According to Leukemia Research, Leukemia causes the death of approximately 68,000 every year. Adults are 10 times more likely to develop the disease, compared to children.
And, Non-Hodgkin's lymphoma is the 7th most common cancer in the U.S. The 5-year survival rate for all subtypes of leukemia is 61.4 percent.
Certain types of blood disorder, exposure to radioactive substances, and certain medication are some of the prevalent risks of cancer.
Some researchers suggested that cigarette smoking may contribute to the large part of AML onset compared to other subtypes.
Dr. Fircanis S in the study of "The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies" wrote in the final report, "current and ever smokers have 40% (RR 1.40, 95% CI 1.22-1.60; P < 0.001) and 25% (RR 1.25, 95% CI 1.15-1.36; P < 0.001) increased risk of developing AML when compared with non-smokers".
And, "Intensity of smoking of <10, 10-20, 20-30, and >30 cigarettes per day was associated with RRs of AML of 1.27, 1.36, 1.55, and 1.77, respectively (P < 0.001 for trend). Duration of smoking of <20 and >20 years was associated with RRs of 1.07 and 1.44, respectively (P < 0.001 for trend). Cumulative smoking of <10, 10-20, 20-30, and >30 pack-years was associated with RRs of 1.13, 1.23, 1.39, and 1.71, respectively (P < 0.001 for trend)".
The results strongly suggested that cigarette smoking is a major risk factor of acute myeloid leukemia and the risk of AML is increased depending on how many cigarettes that a person smokes a day.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural whole food for the treatment of leukemia against the overexpression of proinflammatory cytokines investigated the extract and 3 participating compounds of artichoke leaves (bracts on the human leukemia cell line.
Injection of the artichoke extract and compounds showed to modulate the lipopolysaccharide (LPS)-induced activation of proinflammatory protein (NF-κB) and the intracellular proinflammatory reactive oxygen species.
Low concentrations of the extract inhibited the enzyme AKR1B1 associated with the activation of NF-κB and the expression of pro-inflammatory genes.
The efficacy of the extract in the attenuation of the expression of the inflammation-related enzymes COX-2 and MMP-2 was attributed to the inhibiting activity of NF-κB.
In other words, artichoke reduced the production of inflammatory cytokines by inhibiting the levels of intracellular reactive oxygen species in activation of the protein NF-κB.
By suppressing the enzyme AKR1B1, artichoke reduced the inflammatory expression in facilitating the onset of leukemia.
Furthermore, in order to reveal more information about artichoke extract (CCE) against leukemia researchers evaluated the CCE effect on the growth of L1210 and HL-60 leukemia cells.
Injection with a variety of concentrations of CCE (500-2500 microg/microL) for 24 h resulted in dose-dependent inhibition of leukemia cell growth observed by the cell cycle arrest in S phase.
CCE also induced apoptosis of leukemia cells, detected by the sub-G(0) cell population and apoptotic DNA fragmentation.
The findings suggested that CCE inhibits leukemia cells through several mechanisms including the proteins associated with cell cycle division, inflammation, and cell degradation.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of leukemia, pending to the result of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells by Miláčková I1, Kapustová K1, Mučaji P1, Hošek J. (PubMed)
(2) Growth inhibitory effect of ethyl acetate-soluble fraction of Cynara cardunculus L. in leukemia cells involves cell cycle arrest, cytochrome c release and activation of caspases by Nadova S1, Miadokova E, Mucaji P, Grancai D, Cipak L. (PubMed)
(3) The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies by Fircanis S1, Merriam P, Khan N, Castillo JJ. (PubMed)
Tualang Honey the Best to Boosts Memory
Honey may have a profound and positive effect in boosting human memory, some scientists suggested
Memory is a process of the minds in learning and storing information.
Memory impairment is a condition of not remembering the new and current event which may be recalled in a short period of time, affecting mostly the older population.
Memory impairment is early symptoms associated with late-life neurodegenerative diseases.
Contrast to general belief, memory impairment not only is associated with the progression of neurodegenerative diseases but also can be caused by other factors such as medical conditions including stroke and brain injury.
Long-term use of certain medications such as antidepressants, antihistamines, anti-anxiety medications, excessive alcohol drinking, substance abuse, and tobacco are some major risk factors associated with the onset of memory loss.
Some researchers suggested that people who are living under long-term stress and anxiety or follow a nutritionally deficient diet are most vulnerable to the condition develops.
According to the article "Stress might lead to memory loss and brain shrinkage, study says" By Sandee LaMotte, CNN wrote, "If you live a high-stress life, you could have memory loss and brain shrinkage before you turn 50, according to a study published Wednesday in the journal Neurology".
"Higher levels of cortisol, a stress hormone, seem to predict brain function, brain size and performance on cognitive tests," said study author Dr. Sudha Seshadri, professor of neurology at UT Health San Antonio.
"We found memory loss and brain shrinkage in relatively young people long before any symptoms could be seen," Seshadri said. "It's never too early to be mindful of reducing stress."
In other words, long-term stress can induce the production of certain hormones such as cortisol which have strong implications on the brain in the induction of memory loss.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding the correlation and association with the aging and stress exposure and memory impairment, researchers examined the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress.
Tested rats were given orally, 200 mg/kg body weight of Tualang honey supplementation for 28 days, before exposing to the loud noise, 100 dB(A), 4 hours daily for 14 days.
Rats subjected to noise stress exhibited significantly lower memory performance and higher oxidative stress, through the increased expression of oxidative stress markers, the elevated malondialdehyde, and protein carbonyl levels.
The stress rats also exhibited a reduction of the levels of antioxidant enzymes compared to the nonstressed rats.
Tualang honey supplementation applied to the stress rats showed a significant improvement of the memory performance, by decreasing oxidative stress levels and increasing the brain-derived neurotrophic factor (BDNF) concentration, which was reduced due to stress.
Furthermore, Tualang honey also normalized the ratio of free radicals and antioxidants in the stress rats body and enhanced neuronal proliferation in the medial prefrontal cortex (mPFC) and hippocampus associated to the memory, particularly, in long-term memory.
Dr. Azman KF, the lead scientist at the final report wrote, "Tualang honey protects against memory decline due to stress exposure and/or aging via enhancement of mPFC and hippocampal morphology possibly secondary to a reduction in brain oxidative stress and/or upregulation of BDNF concentration and cholinergic system".
The results underlined the effects of Tualang honey effect in boosting the short and long-term memory which was significantly reduced by stress exposure and/or aging.
Moreover, in the study of the total of forty-eight adult male rats randomly divided into the following four groups: i) nonstressed with vehicle, ii) nonstressed with Tualang honey, iii) stressed with vehicle, and iv) stressed with honey with supplement was given once daily via oral gavage at 0.2 g/kg body weight, researchers found that
* The rats subjected to noise stress was found to process higher levels of depressive-like behavior and lower memory functions compared to the unexposed control rats.
* Tuatang honey supplementation regimen successfully counteracted the effects of noise stress.
* Tualng honey also increased the climbing and swimming and mobility times significantly.
These results suggested that Tualang honey normalizes the cognitive function of the rats exposed to the noise stress, similar to those of the first study.
Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary therapy for the treatment of cognitive impairment, pending to the larger and multi center's human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats by Azman KF1, Zakaria R1, Abdul Aziz CB1, Othman Z2. (PubMed)
(2) Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress by Azman KF1, Zakaria R, AbdAziz C, Othman Z, Al-Rahbi B. (PubMed)
(3) Potential Role of Honey in Learning and Memory by Othman Z1, Zakaria R2, Hussain NHN3, Hassan A4, Shafin N5, Al-Rahbi B6, Ahmad AH. (PubMed)
Thursday, March 21, 2019
Phytochemical Phytic acid, the Potential Anti Diabetes Bioactive Compound, Scientists Find
Scientists may have found a natural resource for the prevention and treatment of diabetes with no side effects, according to the studies.
Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.
The diabetes is either caused by cells in pancreas died off due to the immune system mistakenly attacked the sell in the pancreas or receptor sites clogged up as a result of the excess fat and cholesterol in the bloodstream.
Researchers do not know why the immune system attacks its own tissue. Either they can explain people follow a lifelong intake of the Western diet, only some are susceptible to the onset of the disease, while others do not.
There are many risk factors such as age, ethnicity, family history, impaired glucose tolerance, insulin resistance, being an overweight or obese and sedentary lifestyle. associated with the onset of the condition, epidemiologically. However, many people with some of the risk factors have never developed diabetes.
Some researchers suggested that unhealthy diet with high amounts of saturated and trans fat, red meat and processed foods and low amounts of fruits and vegetable as that of the Western diet is the most common risk factor of diabetes in the Western world.
Dr. David Hefner, in the concern of the Western diet in risk of diabetes, wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes".
And, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
The results strongly suggested the risk of diabetes can be decreased with the change of diet pattern, from the Western diet to a healthy diet with high amounts of fruits and vegetables.
If you experience some of the belove symptoms such as increased thirst that can not be resolved by intake of liquid, frequent urination, extreme hunger, and unexplained weight loss, you may have type 2 diabetes. Please make sure you check with your doctor to rule out the possibility.
Phytic acid (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
On finding a natural bioactive compound for the treatment of diabetes with no side effects, researchers examined the effect of the phytic acid supplement on streptozotocin-induced diabetic rats.
Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. According to the assay used for the experiment, phytic acid supplement treated group showed an increase in average food intake and a decrease in body weight gain compared to the diabetic and normal control groups.
Compared to other groups, phytic acid supplement treated group also exerted a downtrend in intestinal amylase activity. The spike in random blood glucose in the treatment group also lower compared to others.
Furthermore, the treatment group also displays reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels and levels of serum alkaline phosphatase and alanine aminotransferase activities, the indication of improvement of insulin sensitivity.
Moreover, levels of pro-inflammatory cytokines also lower in phytic acid supplement treated group compared to other groups.
Dr.Omoruyi FO, the lead scientist at the end of the study, wrote, "phytic acid supplementation may be beneficial in the management of diabetes mellitus".
Additionally, researchers randomly assigned six groups of rats fed to test the anti-diabetes of phytic acid, for 3 weeks as follows:
* Groups 1 and 2 were fed formulated diets supplemented with zinc or without zinc respectively.
* Groups 3 and 4 were fed formulated diets supplemented with zinc plus phytic acid extracted from sweet potato (Ipomea batatas) or commercial phytic acid respectively.
* Groups 5 and 6 were fed formulated diets supplemented with a phytic acid extract from sweet potato or commercial phytic acid respectively.
At the final day of the experiment, researchers found that phytic acid extract consumption from sweet potato and commercial phytic acid plus zinc supplement lowered blood glucose levels.
However, phytic acid supplementation showed no significant decrease in the activity of pyruvate kinase involved in the insulin stimulation of this enzyme activity, compared to the group fed formulated diets.
Groups fed phytic extract from sweet potato also exerted a significant increase in the activity of glucose-6-phosphate dehydrogenase in the promotion of pancreatic beta-cell function, compared to the other groups.
Taken altogether, phytochemical phytic acid may be used for the prevention and combined with the primary medicine for the treatment and management of type 2 diabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats by Omoruyi FO1, Budiaman A1, Eng Y1, Olumese FE2, Hoesel JL3, Ejilemele A3, Okorodudu AO (PubMed)
(2) The effect of phytic acid on the levels of blood glucose and some enzymes of carbohydrate and lipid metabolism by Dilworth LL, Omoruyi FO, Simon OR, Morrison EY, Asemota HN(PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (NMA)
Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.
The diabetes is either caused by cells in pancreas died off due to the immune system mistakenly attacked the sell in the pancreas or receptor sites clogged up as a result of the excess fat and cholesterol in the bloodstream.
Researchers do not know why the immune system attacks its own tissue. Either they can explain people follow a lifelong intake of the Western diet, only some are susceptible to the onset of the disease, while others do not.
There are many risk factors such as age, ethnicity, family history, impaired glucose tolerance, insulin resistance, being an overweight or obese and sedentary lifestyle. associated with the onset of the condition, epidemiologically. However, many people with some of the risk factors have never developed diabetes.
Some researchers suggested that unhealthy diet with high amounts of saturated and trans fat, red meat and processed foods and low amounts of fruits and vegetable as that of the Western diet is the most common risk factor of diabetes in the Western world.
Dr. David Hefner, in the concern of the Western diet in risk of diabetes, wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes".
And, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
The results strongly suggested the risk of diabetes can be decreased with the change of diet pattern, from the Western diet to a healthy diet with high amounts of fruits and vegetables.
If you experience some of the belove symptoms such as increased thirst that can not be resolved by intake of liquid, frequent urination, extreme hunger, and unexplained weight loss, you may have type 2 diabetes. Please make sure you check with your doctor to rule out the possibility.
Phytic acid (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
On finding a natural bioactive compound for the treatment of diabetes with no side effects, researchers examined the effect of the phytic acid supplement on streptozotocin-induced diabetic rats.
Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. According to the assay used for the experiment, phytic acid supplement treated group showed an increase in average food intake and a decrease in body weight gain compared to the diabetic and normal control groups.
Compared to other groups, phytic acid supplement treated group also exerted a downtrend in intestinal amylase activity. The spike in random blood glucose in the treatment group also lower compared to others.
Furthermore, the treatment group also displays reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels and levels of serum alkaline phosphatase and alanine aminotransferase activities, the indication of improvement of insulin sensitivity.
Moreover, levels of pro-inflammatory cytokines also lower in phytic acid supplement treated group compared to other groups.
Dr.Omoruyi FO, the lead scientist at the end of the study, wrote, "phytic acid supplementation may be beneficial in the management of diabetes mellitus".
Additionally, researchers randomly assigned six groups of rats fed to test the anti-diabetes of phytic acid, for 3 weeks as follows:
* Groups 1 and 2 were fed formulated diets supplemented with zinc or without zinc respectively.
* Groups 3 and 4 were fed formulated diets supplemented with zinc plus phytic acid extracted from sweet potato (Ipomea batatas) or commercial phytic acid respectively.
* Groups 5 and 6 were fed formulated diets supplemented with a phytic acid extract from sweet potato or commercial phytic acid respectively.
At the final day of the experiment, researchers found that phytic acid extract consumption from sweet potato and commercial phytic acid plus zinc supplement lowered blood glucose levels.
However, phytic acid supplementation showed no significant decrease in the activity of pyruvate kinase involved in the insulin stimulation of this enzyme activity, compared to the group fed formulated diets.
Groups fed phytic extract from sweet potato also exerted a significant increase in the activity of glucose-6-phosphate dehydrogenase in the promotion of pancreatic beta-cell function, compared to the other groups.
Taken altogether, phytochemical phytic acid may be used for the prevention and combined with the primary medicine for the treatment and management of type 2 diabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats by Omoruyi FO1, Budiaman A1, Eng Y1, Olumese FE2, Hoesel JL3, Ejilemele A3, Okorodudu AO (PubMed)
(2) The effect of phytic acid on the levels of blood glucose and some enzymes of carbohydrate and lipid metabolism by Dilworth LL, Omoruyi FO, Simon OR, Morrison EY, Asemota HN(PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (NMA)
Phytochemical Piperine, the Potent Immune System Enhancer, According to Studies
Scientists may have found an alkaloid in black pepper for the enhancement of the immune function with no side effects, according to studies.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
Through the expression of the lines of defense, depending on the stage of pathogenic invasion, the innate immune response protects the body via a different set of interaction.
In the acute phase of infection, the macrophages in the immune system stimulate the production of inflammatory cytokines to the site of the damage. The inflammatory cytokines not only play a critical role in stopping the stimuli from entering into the body but also speeds up the wound healing through growth factors.
The innate immune system also can destroy the damage cells such as cancer cell through the T cell activation of B cells which in turn stimulates the production of a protein associated with the production of antibody p53.
Some researchers suggested immune system also can kill cancer cells by reacting to activating cytokines (IFN-α/β, IL-12, IL-15, IL-18, IL-21) produced by tumor cells or by other immune cells stimulated by tumor cells.
Therefore, by modulating the immune responses to the needs of the body, the immune can keep us strong and diseases free.
Dr. Assaf Marcus and colleagues in the investigation of the study "Recognition of tumors by the innate immune system and natural killer cells" wrote, " First, cell-intrinsic mechanisms, like any other mechanism, are prone to failure, necessitating the existence of redundant systems. A second, unique, benefit of immune mechanisms of tumor suppression is that they can act in a paracrine manner. Secretion of cytokines such as IFN-γ, for example, can suppress the growth of neighboring tumor cells even if they do not upregulate immune-activating ligands".
And, "Secretion of cytokines such as IFN-γ, for example, can suppress the growth of neighboring tumor cells".
These results clearly suggested by keeping your immune system strong, you can be free for infectious diseases and cancers.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
With an aim to find a natural bioactive compound which processes the immune enhancing effect researchers assessed the production of antibody response against Russell's viper venom in mice after prophylactic immunization with ethanolic extract of fruits of Piper longum L. and piperine, compared to that of the Polyvalent anti-snake venom serum (antivenom)(PLE) manufactured by Haffkine Bio-Pharmaceutical Corporation Ltd.
According to the results from the tested assay, treatment with PLE-treated mice serum and piperine-treated mice serum was found to inhibit the lethal action of venom both in the in vitro.
Futhermore, there were significantly high (p<0.01) levels of cross-reactions between the PLE and piperine treated mice serum and the venom antigens.
However, immunization with ethanolic extract of fruits of Piper longum and piperine produced a high titer antibody response against Russell's viper venom in mice, compared to PLE.
These results suggested that piperine stimulated the immune function in producing antigens against the lethal action of venom may be considered a potential for the development of antivenom formulation as an antidote against snake bites.
In embryonated fertile chicken eggs, researchers found that PLE was found to inhibit the venom-induced hemorrhage in the eggs.
Combined administration of PLE and piperine significantly inhibited venom-induced lethality, hemorrhage, necrosis, defibrinogenation and inflammatory paw edema in mice in a dose-dependent manner.
LE and piperine also significantly (p<0.01) reduced venom-induced mast cell degranulation in rats by improving the immune responses to inflammatory and allergic reactions.
Before treatment, the injection of venom in mice showed reduced levels of catalase enzyme levels in mice kidney tissue and an increase in creatine kinase enzyme levels, the indication of inflammation.
Combined administration of both PLE and piperine also restored the antioxidant enzymes which were suppressed by the injection of venom in mice
These findings suggested that piperine not only protects our body against venom-induced hemorrhage, necrosis, defibrinogenation but also inhibited an overreaction of the immune response in the stimulation of inflammation.
Moreover, piperine is effective compared to those of antivenom medicine.
Taken altogether, Piperine may be considered a bioactive compound for the treatment of venom caused by insect and poison animal bites, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Production of high titre antibody response against Russell's viper venom in mice immunized with ethanolic extract of fruits of Piper longum L. (Piperaceae) and piperine by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(2) Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell's viper venom: characterization of piperine as active principle by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(3) Recognition of tumors by the innate immune system and natural killer cells by Assaf Marcus, Benjamin G. Gowen, Thornton W. Thompson, Alexandre Iannello, Michele Ardolino, Weiwen Deng, Lin Wang, Nataliya Shifrin, and David H. Raulet. (PMC)
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
Through the expression of the lines of defense, depending on the stage of pathogenic invasion, the innate immune response protects the body via a different set of interaction.
In the acute phase of infection, the macrophages in the immune system stimulate the production of inflammatory cytokines to the site of the damage. The inflammatory cytokines not only play a critical role in stopping the stimuli from entering into the body but also speeds up the wound healing through growth factors.
The innate immune system also can destroy the damage cells such as cancer cell through the T cell activation of B cells which in turn stimulates the production of a protein associated with the production of antibody p53.
Some researchers suggested immune system also can kill cancer cells by reacting to activating cytokines (IFN-α/β, IL-12, IL-15, IL-18, IL-21) produced by tumor cells or by other immune cells stimulated by tumor cells.
Therefore, by modulating the immune responses to the needs of the body, the immune can keep us strong and diseases free.
Dr. Assaf Marcus and colleagues in the investigation of the study "Recognition of tumors by the innate immune system and natural killer cells" wrote, " First, cell-intrinsic mechanisms, like any other mechanism, are prone to failure, necessitating the existence of redundant systems. A second, unique, benefit of immune mechanisms of tumor suppression is that they can act in a paracrine manner. Secretion of cytokines such as IFN-γ, for example, can suppress the growth of neighboring tumor cells even if they do not upregulate immune-activating ligands".
And, "Secretion of cytokines such as IFN-γ, for example, can suppress the growth of neighboring tumor cells".
These results clearly suggested by keeping your immune system strong, you can be free for infectious diseases and cancers.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
With an aim to find a natural bioactive compound which processes the immune enhancing effect researchers assessed the production of antibody response against Russell's viper venom in mice after prophylactic immunization with ethanolic extract of fruits of Piper longum L. and piperine, compared to that of the Polyvalent anti-snake venom serum (antivenom)(PLE) manufactured by Haffkine Bio-Pharmaceutical Corporation Ltd.
According to the results from the tested assay, treatment with PLE-treated mice serum and piperine-treated mice serum was found to inhibit the lethal action of venom both in the in vitro.
Futhermore, there were significantly high (p<0.01) levels of cross-reactions between the PLE and piperine treated mice serum and the venom antigens.
However, immunization with ethanolic extract of fruits of Piper longum and piperine produced a high titer antibody response against Russell's viper venom in mice, compared to PLE.
These results suggested that piperine stimulated the immune function in producing antigens against the lethal action of venom may be considered a potential for the development of antivenom formulation as an antidote against snake bites.
In embryonated fertile chicken eggs, researchers found that PLE was found to inhibit the venom-induced hemorrhage in the eggs.
Combined administration of PLE and piperine significantly inhibited venom-induced lethality, hemorrhage, necrosis, defibrinogenation and inflammatory paw edema in mice in a dose-dependent manner.
LE and piperine also significantly (p<0.01) reduced venom-induced mast cell degranulation in rats by improving the immune responses to inflammatory and allergic reactions.
Before treatment, the injection of venom in mice showed reduced levels of catalase enzyme levels in mice kidney tissue and an increase in creatine kinase enzyme levels, the indication of inflammation.
Combined administration of both PLE and piperine also restored the antioxidant enzymes which were suppressed by the injection of venom in mice
These findings suggested that piperine not only protects our body against venom-induced hemorrhage, necrosis, defibrinogenation but also inhibited an overreaction of the immune response in the stimulation of inflammation.
Moreover, piperine is effective compared to those of antivenom medicine.
Taken altogether, Piperine may be considered a bioactive compound for the treatment of venom caused by insect and poison animal bites, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Production of high titre antibody response against Russell's viper venom in mice immunized with ethanolic extract of fruits of Piper longum L. (Piperaceae) and piperine by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(2) Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell's viper venom: characterization of piperine as active principle by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(3) Recognition of tumors by the innate immune system and natural killer cells by Assaf Marcus, Benjamin G. Gowen, Thornton W. Thompson, Alexandre Iannello, Michele Ardolino, Weiwen Deng, Lin Wang, Nataliya Shifrin, and David H. Raulet. (PMC)
Wednesday, March 20, 2019
Bilberry May Process Anti Breast Cancer Potency with No Side Effects, According to Medical Literature
Bilberry may be the next potential and therapeutic treatment of breast cancer with no side effects, according to studies.
Breast cancer is the chronic condition characterized by irregular cells growth in the breast tissue caused by the alternation of DNA.
The causes of breast cancer are unknown, As of today, researchers cannot explain why people with the same health conditions in the same family, some are susceptible to the onset of breast cancer while others do not.
According to the statistics, 1 in 8 U.S. women, representing 12.4 % of all women will develop invasive breast cancer over the course of her lifetime.
Believe or not, In 2018, approximately 266,120 new cases of invasive breast cancer were diagnosed in women in the U.S.
The 5 years survival rate of breast cancer diagnosis at the early stage is 100%. Therefore, women at a higher risk of breast cancer should examine their breast at least once a month for preventive measure.
Most cases of breast cancer begin in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
Women with breast cancer may experience symptoms of lump, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, and scaliness.
If you experience some of the above symptoms, please make sure to check with your doctor as soon as possible to rule out the possibility of breast cancer.
In North America, some researchers suggested that obesity may have some strong impact on the risk of breast cancer onset.
Dr. Manuel Picon‐Ruiz, the lead scientist in the study of "Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention", wrote "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
And, " the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".
The results clearly suggested that if you are obese, your risk of breast cancer is increased substantially, compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of breast cancer examined the bilberry effect on the MCF7 human breast cancer cells.
Bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.3-0.4 mg/mL.
At this concentration, the natural compound also concerts the induction of apoptotic cell death of the cancer cells with no apparent effect on the microtubule that provides structure and shape to the cytoplasm of eukaryotic cells or actin cytoskeletons.
In other words, bilberry extract induced cancer cell apoptosis was not through cell cycle arrest at this concentration.
However, at the higher extract concentrations (0.5-0.9 mg/mL), the extract did cause an increase in the fraction of cells at the G(2)/M phase of the cell cycle.
Further differentiation of the cell death, bilberry extract at 0.3-0.4 mg/mL did not appreciably inhibit microtubule polymerization in vitro, but significant inhibition of polymerization (approximately 30%) did occur at higher extract concentrations (0.5-1 mg/mL).
Moreover, researchers found that the efficacy of bilberry against breast cancer cell was attributed not by the expression of anthocyanins but all phytochemicals in the extracts.
Dr. Nguyen V and colleagues wrote in the final report, " (Bilberry extract) inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis.
And, "At somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules".
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of breast cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells by Nguyen V1, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., Cynthia Morata‐Tarifa, Ph.D., Janeiro J. Valle‐Goffin, MD, Eitan R. Friedman, MD, and Joyce M. Slingerland, MD, Ph.D. (PMC)
Breast cancer is the chronic condition characterized by irregular cells growth in the breast tissue caused by the alternation of DNA.
The causes of breast cancer are unknown, As of today, researchers cannot explain why people with the same health conditions in the same family, some are susceptible to the onset of breast cancer while others do not.
According to the statistics, 1 in 8 U.S. women, representing 12.4 % of all women will develop invasive breast cancer over the course of her lifetime.
Believe or not, In 2018, approximately 266,120 new cases of invasive breast cancer were diagnosed in women in the U.S.
The 5 years survival rate of breast cancer diagnosis at the early stage is 100%. Therefore, women at a higher risk of breast cancer should examine their breast at least once a month for preventive measure.
Most cases of breast cancer begin in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
Women with breast cancer may experience symptoms of lump, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, and scaliness.
If you experience some of the above symptoms, please make sure to check with your doctor as soon as possible to rule out the possibility of breast cancer.
In North America, some researchers suggested that obesity may have some strong impact on the risk of breast cancer onset.
Dr. Manuel Picon‐Ruiz, the lead scientist in the study of "Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention", wrote "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
And, " the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".
The results clearly suggested that if you are obese, your risk of breast cancer is increased substantially, compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of breast cancer examined the bilberry effect on the MCF7 human breast cancer cells.
Bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.3-0.4 mg/mL.
At this concentration, the natural compound also concerts the induction of apoptotic cell death of the cancer cells with no apparent effect on the microtubule that provides structure and shape to the cytoplasm of eukaryotic cells or actin cytoskeletons.
In other words, bilberry extract induced cancer cell apoptosis was not through cell cycle arrest at this concentration.
However, at the higher extract concentrations (0.5-0.9 mg/mL), the extract did cause an increase in the fraction of cells at the G(2)/M phase of the cell cycle.
Further differentiation of the cell death, bilberry extract at 0.3-0.4 mg/mL did not appreciably inhibit microtubule polymerization in vitro, but significant inhibition of polymerization (approximately 30%) did occur at higher extract concentrations (0.5-1 mg/mL).
Moreover, researchers found that the efficacy of bilberry against breast cancer cell was attributed not by the expression of anthocyanins but all phytochemicals in the extracts.
Dr. Nguyen V and colleagues wrote in the final report, " (Bilberry extract) inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis.
And, "At somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules".
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of breast cancer, pending to the confirmation of larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells by Nguyen V1, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., Cynthia Morata‐Tarifa, Ph.D., Janeiro J. Valle‐Goffin, MD, Eitan R. Friedman, MD, and Joyce M. Slingerland, MD, Ph.D. (PMC)
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