Andrographis may be used as a possible therapeutic herbal medicine for the prevention and treatment of Lung cancer, a Taiwan study suggested.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most common forms of primary lung cancers are derived from epithelial cells. In the US, Lung cancer is the leading cause of cancer deaths of 158,683 people, including 88,329 men and 70,354 women, according to the 2007 statistic.
According to the National Chung Hsing University, andrographolide, one of the major diterpene lactones found in Andrographis paniculata exhibited anti pulmonary cancer effects in a lung tumor mouse.
Dr. Tung YT, the lead author of the study said, "andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice".
In non-small-cell lung cancer, intake of andrographolide significantly enhanced the function of HLJ1, a novel tumor suppressor in used as a druggable target for non-small-cell lung cancer (NSCLC).
Furthermore, andrographolide also affected the genes expression involved in the cell cycle, apoptosis and adhesion-related biological signaling, leading to inhibition of development and progression of nonsmall cell lung cancer.
Other study insisted that the inhibition of andrographolide on non-small cell lung cancer (NSCLC) A549 cell migration and invasion is also attributed to other mechanisms beside gene expression, such as phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in regulating the cell cycle, VEGF pathway in regulating of tumor angiogenesis,, etc.
There is no doubt that andrographolide may be a promising new anticancer agent used in suppressed tumor growth and invasion in NSCLC, but more studies are necessary to confirm the validation.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas by Tung YT1, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM.(PubMed)
(2) The HLJ1-targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer by Lai YH1, Yu SL, Chen HY, Wang CC, Chen HW, Chen JJ.(PubMed)
(3) Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells by Lin HH1, Tsai CW, Chou FP, Wang CJ, Hsuan SW, Wang CK, Chen JH.(PubMed)
(4) Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway by Lee YC1, Lin HH, Hsu CH, Wang CJ, Chiang TA, Chen JH(PubMed)
Saturday, December 28, 2019
Bilberry Stimulates the Cytotoxic Effects Against Cancer, Scientists Say
Cytotoxicity is a process or action that destroys the living cells, through activating the production of pro-inflammatory cytokines and proteins associated with cell apoptosis and programmed cell death.
Free radical cytotoxicity is the ability of ROS in exerting oxidative stress in the cancer cells, leading to apoptosis.
Cancer is a class of diseases characterized by irregular cell growth due to DNA alternation.
Most cancers do not cause any symptoms at an early stage. However, at the later stage, a larger size of the tumor can press on the nearby blood vessels and nerve cells, causing localized bleeding and severe pain.
Most common symptoms of cancer are unintended weight loss, loss of appetite, fatigue or tiredness and gastrointestinal discomforts and symptoms depending on the location of cancer.
If you experience some of the above symptoms, please check with your doctor to rule out the p[ossibility of the disease.
The causes of cancer are unknown. Researchers can not explain why people with the same health conditions, family history in the same family, some are susceptible to cancer, while others do not.
In normal cells, overproduction of free radicals or oxidative stress can affect the cell lipid, protein, leading to cell damage or alteration of cell DNA.
Most cases of natural remedy in initiating the cytotoxic effects against cancer without causing nearby healthy cell death probably are associated with the stimulation of the production of antioxidants produced by the host and the presence of antioxidants of the remedy.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound with cytotoxic potency examined the bilberry chemical compound in facilitating the onset of cytotoxicity against cancer and neutralizing the neuro cytotoxicity against the formation of plague on K562 Human Erythroleukemic cancer cells and Alzheimer's diseases (AD), respectively.
GroES self-assemble into amyloid fibrils similar to those observed in various neurodegenerative diseases was found to induce cell toxicity.
Before the application of bilberry anthocyanins, injection of soluble intermediate aggregates of GroES exhibited neuronal cell death, rather than forming mature fibrils.
Pretreatment with anthocyanins isolated from bilberry, not only inhibited both fibril formation but also neutralized the toxicity of intermediates.
The findings strongly suggested anthocyanins processes an inhibitory effect on the amyloid fibril formation of various conformational disease-causing proteins.
Oppositely, in cancer perspective, anthocyanins stimulated the tumor suppressor genes to induce apoptosis in cancer cells.
Dr. Seth P. Thibado and colleagues in the study to enhance the chemical compound the bioavailability, observed the cytotoxicity of anthocyanins in an encapsulated in 5.5 nm diameter liposomal micelles, called NutraNanoSpheres (NNS), at a concentration of 2.5 mg/50 µl [25% (w/w) anthocyanins].
Bilberry NNS induced the apoptotic/cytotoxic effects on K562 Human Erythroleukemic cancer cells.
The concentrations of bilberry demonstrated the greatest levels of percentage inhibition of 60–70% at 0.018–1.14 mg/ml (n=6) and 60% inhibition at 4 mg/ml, compared to control.
And, the lowest percentage of inhibition (30%) occurred at 2 mg/ml. The lethal dose 50 was determined to be 0.01–0.04 mg/ml of Bilberry per 105 K562 cells at 72 h of cell culture exposure.
At 48 h incubation, the highest percentage of inhibition was only 27%,.
The findings clearly suggested that NutraNanoSpheres (NNS) demonstrates direct cytotoxic effects, at a concentration which is 8–40 times lower than the levels required for bilberry if not encapsulated.
Taken altogether, bilberry processed abundantly bioactive ingredient anthocyanins may be considered a functional remedy in modulation the cytotoxic activity against cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates by Iwasa H1, Kameda H, Fukui N, Yoshida S, Hongo K, Mizobata T, Kobayashi S, Kawata Y. (PubMed)
(2) Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins by Seth P. Thibado,1 Jerry T. Thornthwaite,2 Thomas K. Ballard,2 and Brandon T. Goodman. (PMC)
Free radical cytotoxicity is the ability of ROS in exerting oxidative stress in the cancer cells, leading to apoptosis.
Cancer is a class of diseases characterized by irregular cell growth due to DNA alternation.
Most cancers do not cause any symptoms at an early stage. However, at the later stage, a larger size of the tumor can press on the nearby blood vessels and nerve cells, causing localized bleeding and severe pain.
Most common symptoms of cancer are unintended weight loss, loss of appetite, fatigue or tiredness and gastrointestinal discomforts and symptoms depending on the location of cancer.
If you experience some of the above symptoms, please check with your doctor to rule out the p[ossibility of the disease.
The causes of cancer are unknown. Researchers can not explain why people with the same health conditions, family history in the same family, some are susceptible to cancer, while others do not.
In normal cells, overproduction of free radicals or oxidative stress can affect the cell lipid, protein, leading to cell damage or alteration of cell DNA.
Most cases of natural remedy in initiating the cytotoxic effects against cancer without causing nearby healthy cell death probably are associated with the stimulation of the production of antioxidants produced by the host and the presence of antioxidants of the remedy.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound with cytotoxic potency examined the bilberry chemical compound in facilitating the onset of cytotoxicity against cancer and neutralizing the neuro cytotoxicity against the formation of plague on K562 Human Erythroleukemic cancer cells and Alzheimer's diseases (AD), respectively.
GroES self-assemble into amyloid fibrils similar to those observed in various neurodegenerative diseases was found to induce cell toxicity.
Before the application of bilberry anthocyanins, injection of soluble intermediate aggregates of GroES exhibited neuronal cell death, rather than forming mature fibrils.
Pretreatment with anthocyanins isolated from bilberry, not only inhibited both fibril formation but also neutralized the toxicity of intermediates.
The findings strongly suggested anthocyanins processes an inhibitory effect on the amyloid fibril formation of various conformational disease-causing proteins.
Oppositely, in cancer perspective, anthocyanins stimulated the tumor suppressor genes to induce apoptosis in cancer cells.
Dr. Seth P. Thibado and colleagues in the study to enhance the chemical compound the bioavailability, observed the cytotoxicity of anthocyanins in an encapsulated in 5.5 nm diameter liposomal micelles, called NutraNanoSpheres (NNS), at a concentration of 2.5 mg/50 µl [25% (w/w) anthocyanins].
Bilberry NNS induced the apoptotic/cytotoxic effects on K562 Human Erythroleukemic cancer cells.
The concentrations of bilberry demonstrated the greatest levels of percentage inhibition of 60–70% at 0.018–1.14 mg/ml (n=6) and 60% inhibition at 4 mg/ml, compared to control.
And, the lowest percentage of inhibition (30%) occurred at 2 mg/ml. The lethal dose 50 was determined to be 0.01–0.04 mg/ml of Bilberry per 105 K562 cells at 72 h of cell culture exposure.
At 48 h incubation, the highest percentage of inhibition was only 27%,.
The findings clearly suggested that NutraNanoSpheres (NNS) demonstrates direct cytotoxic effects, at a concentration which is 8–40 times lower than the levels required for bilberry if not encapsulated.
Taken altogether, bilberry processed abundantly bioactive ingredient anthocyanins may be considered a functional remedy in modulation the cytotoxic activity against cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates by Iwasa H1, Kameda H, Fukui N, Yoshida S, Hongo K, Mizobata T, Kobayashi S, Kawata Y. (PubMed)
(2) Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins by Seth P. Thibado,1 Jerry T. Thornthwaite,2 Thomas K. Ballard,2 and Brandon T. Goodman. (PMC)
Bromelain, Suppresses the Risk and Onset of Colitis
Colitis is a medical condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Depending on the types of colitis, most common prevalent factors found in patients with such as condition are.
* Familial history of inflammatory bowel disease (odds ratio (OR) 4.3)
* Breastfeeding (OR 2.1)
* Bacille Calmette-Guerin vaccination (OR 3.6 )
* History of eczema (OR 2.1 (1-4.5))
* Disease during pregnancy (OR 8.9 (1.5-52)), and
* Bedroom sharing (OR 7.1 (1.9-27.4))
* Crohn's disease both appendectomy and tonsillectomy have positive associations. Well-established
* Smoking status
* If you are over 50, you are at increased to develop colitis.
And * Depression and psychosocial stress, according to the basis of data from the Nurses' Health Study, increase the risk for CD, but not UC, among women. Psychological factors might have been found to induce CD developing.
Furthermore, patients with medicals condition such as hypertension, diabetes, hyperlipidemia, and atrial fibrillation are associated with increased risk to develop ischemic colitis(IC), according to the study by Beijing Hospital, Ministry of Health.
Believe it or not, regular drinking of tap water was a protective factor and ulcerative colitis appendicectomy was a protective factor.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of colitis, researchers examined the effects of bromelain on the inflammatory response that lead to the onset of colitis.
In epithelial TNFR in rats colitis induced by the intracolonic administration of 2, 4, 6-trinitrobenzene sulfonic acid, injection of purified fruit bromelain (PFB) significantly decreased the increased expression of TNFR1 and TNFR2.
Where TNF-α receptor (TNFR) is a proinflammatory cytokine activated by the immune response.
Furthermore, typical symptoms associated with colitis such as infiltration of inflammatory cells, cytokine profiles, epithelial cell apoptosis, and epithelial tight junction barrier dysfunction were significantly ameliorated by PFB.
According to the chemical analysis, fruit bromelain showed a superior inhibition of TNFR2 than that exhibited on TNFR1 compared to those of stem bromelain complex.
In other words, PFB expressed its anti-inflammatory activity by blocking the activation of high expression of epithelial TNFRs.
Based on the findings, researchers said, "PFB-induced TNFR inhibition ameliorated colitis symptoms. These results supply novel insights into potential IBD treatment by PFB".
In other to reveal more information of bromelain anti colitis effects, researchers evaluated the long-term dietary supplementation with pineapple (supplied as juice) in decreasing colon inflammation and neoplasia in Il10(-/-) mice with chronic colitis as compared with bromelain derived from the stem.
Colitis triggered in Il10(-/-) mice by exposure to the non-steroidal anti-inflammatory drug piroxicam for 6 month showed a decreased histologic colon inflammation scores and lower incidence of inflammation-associated colonic neoplasia (35% versus 66%; P < 0.02), with fewer neoplastic lesions/colon (P = 0.05) after receiving treatment of fresh juice.
According to the tested assays, fresh pineapple juice demonstrated proteolytic activity in removing cell surface molecules that can affect leukocyte response.
Dr. Hale LP, the lead scientist wrote in the final report, "long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of colitis associated with inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)
(2) Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis by Zhou Z1, Wang L1, Feng P1, Yin L2, Wang C3, Zhi S3, Dong J1, Wang J1, Lin Y2, Chen D1, Xiong Y4,5, Peng J. (PubMed)
(3) Colitis - The Risk Factors by Kyle J. Norton
Depending on the types of colitis, most common prevalent factors found in patients with such as condition are.
* Familial history of inflammatory bowel disease (odds ratio (OR) 4.3)
* Breastfeeding (OR 2.1)
* Bacille Calmette-Guerin vaccination (OR 3.6 )
* History of eczema (OR 2.1 (1-4.5))
* Disease during pregnancy (OR 8.9 (1.5-52)), and
* Bedroom sharing (OR 7.1 (1.9-27.4))
* Crohn's disease both appendectomy and tonsillectomy have positive associations. Well-established
* Smoking status
* If you are over 50, you are at increased to develop colitis.
And * Depression and psychosocial stress, according to the basis of data from the Nurses' Health Study, increase the risk for CD, but not UC, among women. Psychological factors might have been found to induce CD developing.
Furthermore, patients with medicals condition such as hypertension, diabetes, hyperlipidemia, and atrial fibrillation are associated with increased risk to develop ischemic colitis(IC), according to the study by Beijing Hospital, Ministry of Health.
Believe it or not, regular drinking of tap water was a protective factor and ulcerative colitis appendicectomy was a protective factor.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of colitis, researchers examined the effects of bromelain on the inflammatory response that lead to the onset of colitis.
In epithelial TNFR in rats colitis induced by the intracolonic administration of 2, 4, 6-trinitrobenzene sulfonic acid, injection of purified fruit bromelain (PFB) significantly decreased the increased expression of TNFR1 and TNFR2.
Where TNF-α receptor (TNFR) is a proinflammatory cytokine activated by the immune response.
Furthermore, typical symptoms associated with colitis such as infiltration of inflammatory cells, cytokine profiles, epithelial cell apoptosis, and epithelial tight junction barrier dysfunction were significantly ameliorated by PFB.
According to the chemical analysis, fruit bromelain showed a superior inhibition of TNFR2 than that exhibited on TNFR1 compared to those of stem bromelain complex.
In other words, PFB expressed its anti-inflammatory activity by blocking the activation of high expression of epithelial TNFRs.
Based on the findings, researchers said, "PFB-induced TNFR inhibition ameliorated colitis symptoms. These results supply novel insights into potential IBD treatment by PFB".
In other to reveal more information of bromelain anti colitis effects, researchers evaluated the long-term dietary supplementation with pineapple (supplied as juice) in decreasing colon inflammation and neoplasia in Il10(-/-) mice with chronic colitis as compared with bromelain derived from the stem.
Colitis triggered in Il10(-/-) mice by exposure to the non-steroidal anti-inflammatory drug piroxicam for 6 month showed a decreased histologic colon inflammation scores and lower incidence of inflammation-associated colonic neoplasia (35% versus 66%; P < 0.02), with fewer neoplastic lesions/colon (P = 0.05) after receiving treatment of fresh juice.
According to the tested assays, fresh pineapple juice demonstrated proteolytic activity in removing cell surface molecules that can affect leukocyte response.
Dr. Hale LP, the lead scientist wrote in the final report, "long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of colitis associated with inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)
(2) Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis by Zhou Z1, Wang L1, Feng P1, Yin L2, Wang C3, Zhi S3, Dong J1, Wang J1, Lin Y2, Chen D1, Xiong Y4,5, Peng J. (PubMed)
(3) Colitis - The Risk Factors by Kyle J. Norton
Friday, December 27, 2019
Andrographis, The Immunomodulatory Whole Herb Medicine
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
Immunomodulatory Activity is the action in regulated immune response or the functioning of the immune system against forming of diseases, including stimulating the production of antibody and
inhibited white blood cells in induced inflammation,.....
Andrographis processed significant effects in enhanced immune function, through modulation of immune responses, a renowned institute study suggested.
According to the Prin. K. M. Kundnani College of Pharmacy, HN-02, an extract containing a mixture of andrographolides plus 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide together [12 +/- 3 %]) in pure powder forms at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitro experimental models, demonstrated the ability in enhanced immune function by modulation of immune responses altered during antigen interaction, and to reverse the immunosuppression induced by cyclophosphamide (CYP).
Dr. Naik SR, the lead author said, " HN-02 treatment significant increase in total WBC count" and "elevated the depressed hemagglutination antibody (HA) titer and increased the number of plaque-forming cells (PFCs) in the spleen cells of mice".
Other researchers in the evaluation of the immunomodulatory activity of herbal andrographis indicated that Andrographis paniculata exhibited the effect through genes expression involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation.
The study also identified the chemical compound of lipopolysaccharide in Andrographis paniculata as one of the natural and most active immunostimulatory components.
Additionally, dichloromethane fraction of the methanolic extract of Andrographis paniculata also expressed an impressive inhibition against testing human cancer and immune cells.
At low concentration, the dichloromethane extract enhanced immune function in attenuated the proliferation of HT-29 (colon cancer) cells and human peripheral blood lymphocytes (HPBLs).
Furthermore, the study also found, andrographolide, another major compound in Andrographis paniculata exhibited immune ability to suppress irregular cell growth and cancer activity on diverse cancer cells in different types of human cancers.
Taking all together, there is no doubt, that Andrographis consisted of strong immunomodulatory activity in regulated immune responses against a procession of irregular cell growth and overreaction of foreign harmful substances, but intake of large amounts should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR1, Hule A.(PubMed)
(2) Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals by Denzler KL1, Waters R, Jacobs BL, Rochon Y, Langland JO.(PubMed)
(3) Anticancer and immunostimulatory compounds from Andrographis paniculata by Kumar RA1, Sridevi K, Kumar NV, Nanduri S, Rajagopal S.(PubMed)
Immunomodulatory Activity is the action in regulated immune response or the functioning of the immune system against forming of diseases, including stimulating the production of antibody and
inhibited white blood cells in induced inflammation,.....
Andrographis processed significant effects in enhanced immune function, through modulation of immune responses, a renowned institute study suggested.
According to the Prin. K. M. Kundnani College of Pharmacy, HN-02, an extract containing a mixture of andrographolides plus 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide together [12 +/- 3 %]) in pure powder forms at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitro experimental models, demonstrated the ability in enhanced immune function by modulation of immune responses altered during antigen interaction, and to reverse the immunosuppression induced by cyclophosphamide (CYP).
Dr. Naik SR, the lead author said, " HN-02 treatment significant increase in total WBC count" and "elevated the depressed hemagglutination antibody (HA) titer and increased the number of plaque-forming cells (PFCs) in the spleen cells of mice".
Other researchers in the evaluation of the immunomodulatory activity of herbal andrographis indicated that Andrographis paniculata exhibited the effect through genes expression involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation.
The study also identified the chemical compound of lipopolysaccharide in Andrographis paniculata as one of the natural and most active immunostimulatory components.
Additionally, dichloromethane fraction of the methanolic extract of Andrographis paniculata also expressed an impressive inhibition against testing human cancer and immune cells.
At low concentration, the dichloromethane extract enhanced immune function in attenuated the proliferation of HT-29 (colon cancer) cells and human peripheral blood lymphocytes (HPBLs).
Furthermore, the study also found, andrographolide, another major compound in Andrographis paniculata exhibited immune ability to suppress irregular cell growth and cancer activity on diverse cancer cells in different types of human cancers.
Taking all together, there is no doubt, that Andrographis consisted of strong immunomodulatory activity in regulated immune responses against a procession of irregular cell growth and overreaction of foreign harmful substances, but intake of large amounts should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR1, Hule A.(PubMed)
(2) Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals by Denzler KL1, Waters R, Jacobs BL, Rochon Y, Langland JO.(PubMed)
(3) Anticancer and immunostimulatory compounds from Andrographis paniculata by Kumar RA1, Sridevi K, Kumar NV, Nanduri S, Rajagopal S.(PubMed)
Ashwagandha Increases Body Mass and Strength in Resistance Training Exercise
Body mass calculated by the body mass index (BMI), is a value derived from the mass (weight) and height of a person.
The BMI indes = weight (kg)/ height (m2)
Weight loss is a process that intentionally reduces the total body mass, through the decrease of fluid, body fat or adipose tissue or lean mass.
Obesity is a medical condition of excess body fat that has accumulated over time, while overweight is a condition of excess body weight relative to the height.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of the American population is either overweight or obese.
In North America, over 68% of the US population is either overweight or obese.
The weight loss products is a 66 billion business in the US, according to the statistic provided by the Marketdata LLC research firm. And the business continues to grow at a rapid rate.
Resistance training is a type of exercise associated with the improvement of muscular strength and endurance used most in professional athletics.
The exercise is emphasized to move the limbs against resistance provided by your body weight, gravity, bands, weighted bars or dumbbells.
Today, most resistance training exercise is performed against exercise machines.
Body strength on the resistance training exercise is a type of workout that focuses on the entire body to build lean muscle tissue and strength.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for enhancing the results of resistance training, researchers examined the effects of ashwagandha root extract consumption on muscle mass and strength in healthy young men engaged in resistance training.
The randomized, prospective, double-blind, placebo-controlled clinical study included 57 young male subjects (18-50 years old) with little experience in resistance randomized into treatment (29 subjects) consumed 300 mg of ashwagandha root extract twice daily and placebo (28 subjects) groups consumed starch for 8 weeks.
Compared to the placebo subjects, the group treated with ashwagandha had significantly greater increases in muscle strength on the bench-press exercise and the leg-extension exercise and significantly greater muscle size increase at the arms.
Furthermore, the Ashwagandha treatment group also showed a significant increase in muscle size on the chest.
Furthermore, the Ashwagandha treatment group also reduced the risk of exercise-induced muscle damage by stabilizing the serum creatine kinase and increased the production of testosterone level. compared to control.
Most importantly, compared to control, the Ashwagandha treatment group demonstrated a significantly greater decrease in body fat percentage.
Based on the findings, researchers said, "ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".
Taken altogether, Ashwagandha may be considered a functional herb that increases body mass and strength in resistance training, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Examining the effect of Withania somnifera supplementation on muscle strengthand recovery: a randomized controlled trial by Wankhede S1, Langade D2, Joshi K3, Sinha SR4, Bhattacharyya S. (PubMed)
The BMI indes = weight (kg)/ height (m2)
Weight loss is a process that intentionally reduces the total body mass, through the decrease of fluid, body fat or adipose tissue or lean mass.
Obesity is a medical condition of excess body fat that has accumulated over time, while overweight is a condition of excess body weight relative to the height.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of the American population is either overweight or obese.
In North America, over 68% of the US population is either overweight or obese.
The weight loss products is a 66 billion business in the US, according to the statistic provided by the Marketdata LLC research firm. And the business continues to grow at a rapid rate.
Resistance training is a type of exercise associated with the improvement of muscular strength and endurance used most in professional athletics.
The exercise is emphasized to move the limbs against resistance provided by your body weight, gravity, bands, weighted bars or dumbbells.
Today, most resistance training exercise is performed against exercise machines.
Body strength on the resistance training exercise is a type of workout that focuses on the entire body to build lean muscle tissue and strength.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for enhancing the results of resistance training, researchers examined the effects of ashwagandha root extract consumption on muscle mass and strength in healthy young men engaged in resistance training.
The randomized, prospective, double-blind, placebo-controlled clinical study included 57 young male subjects (18-50 years old) with little experience in resistance randomized into treatment (29 subjects) consumed 300 mg of ashwagandha root extract twice daily and placebo (28 subjects) groups consumed starch for 8 weeks.
Compared to the placebo subjects, the group treated with ashwagandha had significantly greater increases in muscle strength on the bench-press exercise and the leg-extension exercise and significantly greater muscle size increase at the arms.
Furthermore, the Ashwagandha treatment group also showed a significant increase in muscle size on the chest.
Furthermore, the Ashwagandha treatment group also reduced the risk of exercise-induced muscle damage by stabilizing the serum creatine kinase and increased the production of testosterone level. compared to control.
Most importantly, compared to control, the Ashwagandha treatment group demonstrated a significantly greater decrease in body fat percentage.
Based on the findings, researchers said, "ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".
Taken altogether, Ashwagandha may be considered a functional herb that increases body mass and strength in resistance training, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Examining the effect of Withania somnifera supplementation on muscle strengthand recovery: a randomized controlled trial by Wankhede S1, Langade D2, Joshi K3, Sinha SR4, Bhattacharyya S. (PubMed)
Artichoke Protects the Brian Neurons Against Learning and Memory Impairment
Learning is an action of acquired skill or knowledge in a short or lifelong process.
Memory is an act of storing the acquired knowledge expressed to them when they are needed.
In other words, learning and memory is a process involved different stages including acquisition, consolidation, and retrieval.
There are many causes of neuron loss in facilitating the onset of learning and memory impairment. In fact, neuronal apoptosis has been reported to play a key role in the impairment of learning and memory processes
Several toxins such as scopolamine, streptozotocin, quinolinic acid, and domoic acid have been found to utilize based on their mechanism of action for learning and memory impairment.
Toxins induced amyloid-β deposits are known to cause specific learning and memory impairment in patients with Parkinson's disease dementia and Alzheimer's disease dementia.
Environmental pollutants, such as botulinum, and lipopolysaccharide are also considered various classes of neurotoxin models for learning and memory impairment.
Although the increase in aging has been well known to be a major factor in the initiation of the learning and memory impairment in patients with neurodegenerative disease, the genetic mutation also has a strong implication on cognitive functions that can lead to either impairment in learning and memory.
Dr. Niu Q, the lead scientist, in the assessment of the acquired genetic mutation in patients with learning and memory impairment said, "Neuronal apoptosis has become a focus of interest, as it has been reported to play a key role in the impairment of learning and memory processes (Thompson, Science 267:1456, 1995). The Bcl-2 gene acts as an important effector for inhibiting apoptosis".
"Neuronal apoptosis was extensive in the brain of Al-exposed groups, and the expressions of Bcl-2 protein in the frontal cortex, cerebellum, and hippocampus of Al-exposed rats were stronger... and chronic Al-exposure in rats is associated with neuronal apoptosis in the brain, and impaired learning and memory. Augmented Bcl-2 protein expression may be a stimulated compensatory mechanism".
The findings strongly suggested that gene alternation due to long-term exposure to a toxic chemical cause gradual loss and death neurons, leading to learning and memory impairment.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of learning and memory impairment investigated the Stachys sieboldii (Chinese artichoke) neuroprotective effects of S. sieboldii tuber extract in alleviating learning and memory dysfunction associated with vascular dementia or Alzheimer's disease.
Ginkgo biloba leaf extract (ginkgo extract) used as a positive control. Mice were subjected to bilateral carotid artery occlusion (BCAO) for 30 min.
Oral administration of chorogi or ginkgo extracts significantly reduced post-ischemic glucose intolerance on day 1 and neuronal damage including memory impairment on day 3 after BCAO without affecting the locomotor activity.
Furthermore, both chorogi or ginkgo extract insignificantly alleviated scopolamine-induced learning and memory impairments.
In primary neurons, the neuronal survival rate was significantly reduced by hydrogen peroxide was significantly suppressed by chorogi extract and ginkgo extract.
These results suggested, chorogi or ginkgo extract protected the integrity and viability of the neurons by inhibiting the overexpression of free radicals through improving the antioxidant enzymes produced by the mice.
Researchers at the final report wrote. "chorogi extract, as well as ginkgo extract, can protect against learning and memory dysfunction associated with ischemic brain injury through an antioxidative mechanism".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of p learning and memory impairment with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Stachys sieboldii (Labiatae, Chorogi) Protects against Learning and MemoryDysfunction Associated with Ischemic Brain Injury by Harada S1, Tsujita T, Ono A, Miyagi K, Mori T, Tokuyama S. (PubMed)
(2) Toxin-Induced Experimental Models of Learning and Memory Impairment by More SV1, Kumar H2, Cho DY3, Yun YS4, Choi DK. (PubMed)
(3) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats by Niu Q1, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, Conti P, Boscolo P. (PubMed)
Memory is an act of storing the acquired knowledge expressed to them when they are needed.
In other words, learning and memory is a process involved different stages including acquisition, consolidation, and retrieval.
There are many causes of neuron loss in facilitating the onset of learning and memory impairment. In fact, neuronal apoptosis has been reported to play a key role in the impairment of learning and memory processes
Several toxins such as scopolamine, streptozotocin, quinolinic acid, and domoic acid have been found to utilize based on their mechanism of action for learning and memory impairment.
Toxins induced amyloid-β deposits are known to cause specific learning and memory impairment in patients with Parkinson's disease dementia and Alzheimer's disease dementia.
Environmental pollutants, such as botulinum, and lipopolysaccharide are also considered various classes of neurotoxin models for learning and memory impairment.
Although the increase in aging has been well known to be a major factor in the initiation of the learning and memory impairment in patients with neurodegenerative disease, the genetic mutation also has a strong implication on cognitive functions that can lead to either impairment in learning and memory.
Dr. Niu Q, the lead scientist, in the assessment of the acquired genetic mutation in patients with learning and memory impairment said, "Neuronal apoptosis has become a focus of interest, as it has been reported to play a key role in the impairment of learning and memory processes (Thompson, Science 267:1456, 1995). The Bcl-2 gene acts as an important effector for inhibiting apoptosis".
"Neuronal apoptosis was extensive in the brain of Al-exposed groups, and the expressions of Bcl-2 protein in the frontal cortex, cerebellum, and hippocampus of Al-exposed rats were stronger... and chronic Al-exposure in rats is associated with neuronal apoptosis in the brain, and impaired learning and memory. Augmented Bcl-2 protein expression may be a stimulated compensatory mechanism".
The findings strongly suggested that gene alternation due to long-term exposure to a toxic chemical cause gradual loss and death neurons, leading to learning and memory impairment.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of learning and memory impairment investigated the Stachys sieboldii (Chinese artichoke) neuroprotective effects of S. sieboldii tuber extract in alleviating learning and memory dysfunction associated with vascular dementia or Alzheimer's disease.
Ginkgo biloba leaf extract (ginkgo extract) used as a positive control. Mice were subjected to bilateral carotid artery occlusion (BCAO) for 30 min.
Oral administration of chorogi or ginkgo extracts significantly reduced post-ischemic glucose intolerance on day 1 and neuronal damage including memory impairment on day 3 after BCAO without affecting the locomotor activity.
Furthermore, both chorogi or ginkgo extract insignificantly alleviated scopolamine-induced learning and memory impairments.
In primary neurons, the neuronal survival rate was significantly reduced by hydrogen peroxide was significantly suppressed by chorogi extract and ginkgo extract.
These results suggested, chorogi or ginkgo extract protected the integrity and viability of the neurons by inhibiting the overexpression of free radicals through improving the antioxidant enzymes produced by the mice.
Researchers at the final report wrote. "chorogi extract, as well as ginkgo extract, can protect against learning and memory dysfunction associated with ischemic brain injury through an antioxidative mechanism".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of p learning and memory impairment with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Stachys sieboldii (Labiatae, Chorogi) Protects against Learning and MemoryDysfunction Associated with Ischemic Brain Injury by Harada S1, Tsujita T, Ono A, Miyagi K, Mori T, Tokuyama S. (PubMed)
(2) Toxin-Induced Experimental Models of Learning and Memory Impairment by More SV1, Kumar H2, Cho DY3, Yun YS4, Choi DK. (PubMed)
(3) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats by Niu Q1, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, Conti P, Boscolo P. (PubMed)
Arnica, The Herbal Remedy Which Not Only Gobbles Up Breast Cancer Cells But Also Speeds Up Recovery After Post Breast Mastectomy, Medical Literature Showed
Arnica may have a positive and therapeutic effect in reduced risk and treatment of breast cancer, some scientists suggested.
Breast cancer is a medical condition characterized by irregular cell growth in the breast tissue.
According to general belief, 1 in 8 women will be diagnosed with breast cancer during her lifetime.
The causes of the breast are unknown. Researchers do not know why some women are susceptible to DNA alternated in healthy breast tissue while others do not. Truly, many women who have risk factors never develop breast cancer.
Some researchers suggested that family history, early puberty and late onset of menopause, having high breast density, excessive alcohol drinking,.... and aging are associated to increase the risk of breast cancer.
Furthermore, Women who have inherited gene mutation from a parent, have previous cancer,..and
have taken certain medications such as diethylstilbestrol (DES) are also associated with the risk of the disease.
Today modern technology is developed to detect breast cancer in an early stage, but self-examination is still one of the best methods to catch cancer before they can become invasive.
The survival rates of breast cancer have also increased, and the number of deaths associated is steadily decreasing, largely due to factors that women are more aware of the early onset of the disease.
If you experience some symptoms such as breast lump, nipple changes, breast change in the size, shape, inverted nipple, breast skin peeling, scaling, flaking of the pigmented area of skin surrounding the nipple, please check with your doctor to rule out the possibility
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia. The plant has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.
According to the evaluation of cytotoxic chemotherapeutic agents with efficacy without inducing adverse effects from major compounds extracted from Arnica helenalin and to exam whether the compound activity was maximized by encapsulation in β-cyclodextrin nanoparticle, application of β-cyclodextrin nanoparticle alone exerted a significantly inhibitory property against breast cancer cells.
β-Cyclodextrin (β-CD) is a cyclic oligosaccharide comprising seven D-glucopyranoside units, linked through 1,4-glycosidic bonds.
Interestingly, when helenalin was encapsulation in β-cyclodextrin nanoparticle, the combination demonstrated a significant effect in the induction of breast cancer cell cytotoxicity in compared to administration of helenalin alone.
These results suggested that certain compounds in β-cyclodextrin may have potential in stimulated and enhanced the helenalin action through some unknown interacted mechanisms.
In T47D breast cancer cell line, injection of β-cyclodextrin- helenalin complexes inhibited the preoperative effect in the prevented expanse of the colony in a dose-dependent manner.
Some researchers suggested that the induction of breast cancer cell apoptosis and proliferation may be attributed to helenalin antioxidants activity in restricting the growth of cells through its stimulation of ROS in facilitated cell death.
More importantly, the application of β-cyclodextrin- helenalin also improved the ratio of antioxidant and ROS in the infectious cell line. These results were observed in the expression of the telomerase gene through the r q-PCR.
Truly, the length of the terminal transferase was shortening in the treated cell lines compared to untreated control.
Furthermore, the application of Arnica also expressed a profound effect in reduced blood and serum volumes and pain, and the presence of bruising or hematomas during the period of drainage.
According to study of 53 women, undergoing unilateral total mastectomy, selected from 2012 to 2014 randomly assigned to A. montana or placebo and followed up for 5 days, conducted by the Niguarda Ca' Granda Hospital, Milan, Arnica treatment of group displayed a strong reduction of the of mean volume of blood and serum collected in drainages in compared to control group observed by the per-protocol analysis.
Analysis of the questionnaire returned from the patients, researchers found that patient weight showed a statistically significant difference in favor in the use of Arnica, according to the regression model including treatment, volume collected in the drainage on the day of surgery.
Moreover, the blood and serum volumes collected on the day of surgery and the following days were significantly lower with Arnica at days 2 in compared to untreated patients.
Dr.Sorrentino L, the lead author, after taking into account other co and confounders said, " reduce post-operative blood and seroma collection in women undergoing unilateral total mastectomy".
The findings suggested that Arnica and its major bioactive helenalin may be used as a secondary herbal treatment or combination with standard medicine for the treatment of breast cancer and speeding up recovery after post total mastectomy.
Intake of herbal supplement should be taken with extreme care to prevent acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Is there a role for homeopathy in breast cancer surgery? A first randomized clinical trial on treatment with Arnica montana to reduce post-operative seroma and bleeding in patients undergoing total mastectomy by Sorrentino L1, Piraneo S1, Riggio E1, Basilicò S2, Sartani A1, Bossi D3, Corsi F4.(PubMed)
(2) Inhibitory effects of β-cyclodextrin-helenalin complexes on H-TERT gene expression in the T47D breast cancer cell line - results of real time quantitative PCR by Ghasemali S1, Nejati-Koshki K, Tafsiri E, Rahmati-Yamchi M, Akbarzadeh A, Alizadeh E, Abbasi M, Barkhordari A, Tozihi M, Kordi S, Zarghami N.(PubMed)
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