Saturday, October 17, 2015

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoporosis Treatments In conventional medicine perspective

By Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

V. Treatments
A. In conventional medicine perspective
A.1. Bisphosphonates
1. Including Alendronate (Fosamax), Risedronate (Actonel, Atelvia), Ibandronate (Boniva), Zoledronic acid (Reclast, Zometa), etc..Bisphosphonates are antiresorptive medications widely prescribed for treating osteoporosis. In placebo-controlled clinical trials they have been shown to significantly reduce the risk of osteoporotic fractures(36).
Others suggested that Because bisphosphonate accumulate in bone and provide some residual antifracture reduction when treatment is stopped, we recommend a drug holiday after 5-10 yr of bisphosphonate treatment. The duration of treatment and length of the holiday are based on fracture risk and pharmacokinetics of the bisphosphonate used. Patients at mild risk might stop treatment after 5 yr and remain off as long as bone mineral density is stable and no fractures occur. Higher risk patients should be treated for 10 yr, have a holiday of no more than a year or two, and perhaps be on a nonbisphosphonate treatment during that time(37).

2. Side effects
a. Nausea
b. Abdominal pain
c. Difficulty swallowing
d. Rrisk of an inflamed esophagus or esophageal ulcers(38)
e. Risk of scleritis and a variety of ocular side effects(39)
f. Etc.
2. Hormone-related therapy
Hormone replacement therapy can help to maintain bone density for menopause women, but it increases
a, The risk of breast cancer and heart disease(40)
b. The risk for venous thromboembolism(41)
c. The risk of (Nonmelanoma Skin Cancers) NMSC.(42)
d. The risk of stroke(43)
e. etc.
1000 top Paleo Recipes
The Natural Way to Make Delicious, Healthy,
Fat-Burning Paleo Recipes Quickly And Easily


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Friday, October 16, 2015

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoporosis Prevention - The Antioxidants

By Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Osteoporosis
is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

The preventive Antioxidants

Generalized partial linear model (GPLM) is found to be effective indetermining nonlinear effects of an important continuous-scale risk factor. The final GPLM model shows that TCM symptoms play an important role in assessing the risk of osteoporosis. The GPLM also reveals a nonlinear effect of the important risk factor, menopause years, which might be missed by the generalized linear model.

1. In the study to evaluate whether antioxidant defenses are decreased in elderly osteoporotic women and, if this is the case, to understand whether osteoporosis is a condition characterized by increased oxidative stress, researchers at the Gerontology and Geriatrics, University of Perugia, found that dietary and endogenous antioxidants were consistently lower in osteoporotic than in control subjects. On the other hand, plasma levels of malondialdehyde, a byproduct of lipid peroxidation, did not differ between groups. Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation(32).

2. Selenium plus vitamins E and C
In the study to to investigate the effect of heparin on osteoporosis initiation, and the effect of selenium plus vitamins E and C, and the sole combination of vitamins E and C on the progress of osteoporosis induced by heparin through histologic means, showed that the combination of vitamins E and C given to the experimental rabbits partially prevented this bone tissue destruction. When sodium selenite was given together with vitamins E and C to the osteoporosis model rabbits, the long bone tissue had almost the same structure as in normal rabbits, for example the development of numerous bone trabeculae(33).

3. Vitamin C
According to the study epidemiologic studies correlate low vitamin C intake with bone loss. The genetic deletion of enzymes involved in de novo vitamin C synthesis in mice, likewise, causes severe osteoporosis. In the study of Vitamin C prevents hypogonadal bone loss by School of Stomatology, Wuhan University, Wuhan indicated that the ingestion of vitamin C prevents the low-turnover bone loss following ovariectomy in mice. This prevention in areal bone mineral density and micro-CT parameters results from the stimulation of bone formation, demonstrable in vivo by histomorphometry, bone marker measurements, and quantitative PCR. Notably, the reductions in the bone formation rate, plasma osteocalcin levels, and ex vivo osteoblast gene expression 8 weeks post-ovariectomy are all returned to levels of sham-operated controls(34).

4. Calcium and vitamin D
Calcium supplements reduce the rate of bone loss in osteoporotic patients. Some recent studies have reported a significant positive effect of calcium treatment not only on bone mass but also on fracture incidence. The SENECA study, has also shown that vitamin D insufficiency is frequent in elderly populations in Europe. There are a number of studies on the effects of vitamin D supplementation on bone loss in the elderly, showing that supplementations with daily doses of 400-800 IU of vitamin D, given alone or in combination with calcium, are able to reverse vitamin D insufficiency, to prevent bone loss and to improve bone density in the elderly, according to the Dr. Gennari C. by Institute of Internal Medicine, University of Siena(35)
5. Etc.

Thursday, October 15, 2015

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoporosis Prevention - The Phytochemicals

By Kyle J. Norton(Scholar)
Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

Phytochemicals and osteoarthritis 

1. Epigallocatechin, including catechins, is a phytochemical of Flavan-3-ols, in the group of Flavonoids (polyphenols), found abundantly in green tea, St John wort, black Tea, carob flour, Fuji apples, etc.
a. Inflammatory effects
In the determination of the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG). In TLR2 ligand-stimulated HDPF, found that catechins might be useful therapeutically as an anti-inflammatory modulator of dental pulpal inflammation, according to “Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells” by Hirao K, Yumoto H, Nakanishi T, Mukai K, Takahashi K, Takegawa D, Matsuo T.(47)
b. Antiviral activities
In the observation of Catechin derivatives including (-)-epicatechin gallate (ECG), (-)-epigallocatechin gallate (EGCG), (-)-epigallocatechin (EGC) and green tea extract (GTE) and theirs inhibition of the activities of cloned human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT), duck hepatitis B virus replication complexes reverse transcriptase (DHBV RCs RT), herpes simplex virus 1 DNA polymerase (HSV-1 DNAP) and cow thymus DNA polymerase alpha (CT DNAP alpha, found that GCG exerts a mixed inhibition with respect to external template inducer poly (rA).oligo (dT) 12-18 and a noncompetitive inhibition with respect to substrate dTTP for HIV-1 RT. Bovine serum albumin significantly reduced the inhibitory effects of catechin analogues and GTE on HIV-1 RT. In tissue culture GTE inhibited the cytopathic effect of coxsackie B3 virus, but did not inhibit the cytopathic effects of HSV-1, HSV-2, influenza A or influenza B viruses, according to “[The inhibitory effects of catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and DNA polymerases].[Article in Chinese]” by Tao P.(48)
c. Antioxidants
In the evaluation of the effects of the main polyphenolic components extracted from green tea leaves, i.e. (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin gallate (EGCG) and gallic acid (GA), against free radical initiated peroxidation of human low density lipoprotein (LDL), found that The antioxidative action of the green tea polyphenols includes trapping the initiating and/or propagating peroxyl radicals with the activity sequence EC>EGCG>ECG>EGC>GA for the AAPH initiated peroxidation, and reducing the alpha-tocopheroxyl radical to regenerate alpha-tocopherol with the activity sequence of ECG>EC>EGCG>EGC>GA and ECG>EGCG>GA>EC>EGC for the AAPH-initiated and BP-photosensitized peroxidations respectively, according to “Antioxidative effects of green tea polyphenols on free radical initiated and photosensitized peroxidation of human low density lipoprotein” by Liu Z, Ma LP, Zhou B, Yang L, Liu ZL.(49).

2. Catechin is phytochemical of Flavan-3-ols, in the group of Flavonoids (polyphenols), found abundantly in white tea, green tea, black tea, grapes, wine, apple juice, cocoa, lentils, etc.
a. Body-weight regulation
Green tea has been proposed as a tool for obesity management as strategies for weight loss and weight maintenance, as researchers found that a green tea-caffeine mixture improves weight maintenance, through thermogenesis, fat oxidation, and sparing fat free mass. The sympathetic nervous system is involved in the regulation of lipolysis, and the sympathetic innervation of white adipose tissue may play an important role in the regulation of total body fat in general, according to “Green tea catechins, caffeine and body-weight regulation” byWesterterp-Plantenga MS.(50)
b. Antioxidant activity
In the research on polyphenolic compounds (included catechins) in the berries of edible honeysuckle and their biological effects, including recommended utilization, are reviewed found that These berries seem to be prospective sources of health-supporting phytochemicals that exhibit beneficial anti-adherence and chemo-protective activities, thus they may provide protection against a number of chronic conditions, e.g., cancer, diabetes mellitus, tumour growth or cardiovascular and neurodegenerative diseases, according to “Phenolic profile of edible honeysuckle berries (genus lonicera) and their biological effects” by Jurikova T, Rop O, Mlcek J, Sochor J, Balla S, Szekeres L, Hegedusova A, Hubalek J, Adam V, Kizek R.(51)
c. Anti-inflammatory effect
In the preparation of the gel of Chinese medicine catechu, and to observe the release mechanism in vitro and anti-inflammatory activity in rats, found that the optimum condition of extraction from catechu was as follows, the concentration of ethanol, ratio of raw material to solvent, ultrasonic time, and extraction temperature were 50% , 1: 12, 35 min and 60 degrees C, respectively. The formulation of catechu gel was carbomer-9 400.5 g, glycerol 5.0 g, the extracts of catechu 50.0 mL, and triethanomine 0.5 mL The gel was semitransparent and stable. The drugs released quickly. The catechu gel reduced the paw edema considerably in dose-dependent manner compared to carrageenan-induced rat, according to “[Preparation and pharmacodynamics studies on anti-inflammatory effect of catechu gel].[Article in Chinese]” by Zheng X, Zheng C.(52).

3. Theaflavin-3,3′-digallate, a theaflavin derivative, is phytochemicals of Flavan-3-ols, in the group of Flavonoids (polyphenols) found abundantly in black tea.
a. Antioxidant capacities
In the comparison of TF derivatives (theaflavin (TF(1)), theaflavin-3-gallate (TF(2)A), theaflavin-3′-gallate (TF(2)B), and theaflavin-3,3′-digallate (TF(3))) in scavenging reactive oxygen species (ROS) in vitro, indicated that positive antioxidant capacities of TF(2)B on singlet oxygen, hydrogen peroxide, hydroxyl radical, and the hydroxyl radical-induced DNA damage in vitro were found, according to “Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses” by Wu YY, Li W, Xu Y, Jin EH, Tu YY.(53)
b. Antimicrobial activities
In the evaluation of the antimicrobial activities of seven green tea catechins and four black tea theaflavins, found that (-)-gallocatechin-3-gallate, (-)-epigallocatechin-3-gallate, (-)-catechin-3-gallate, (-)-epicatechin-3-gallate, theaflavin-3, 3′-digallate, theaflavin-3′-gallate, and theaflavin-3-gallate showed antimicrobial activities at nanomolar levels; (ii) most compounds were more active than were medicinal antibiotics, such as tetracycline or vancomycin, at comparable concentrations; (iii) the bactericidal activities of the teas could be accounted for by the levels of catechins and theaflavins as determined by high-pressure liquid chromatography; (iv) freshly prepared tea infusions were more active than day-old teas; and (v) tea catechins without gallate side chains, gallic acid and the alkaloids caffeine and theobromine also present in teas, and herbal (chamomile and peppermint) teas that contain no flavonoids are all inactive, according to “Antimicrobial activities of tea catechins and theaflavins and tea extracts against Bacillus cereus” byFriedman M, Henika PR, Levin CE, Mandrell RE, Kozukue N.(54)
c. anti inflammation
found that a single topical application of equimolar of black tea constituents (TF, theaflavin-3-gallate, theaflavin-3′-gallate, and theaflavin-3,3′-digallate) strongly inhibited TPA-induced edema of mouse ears. Application of TFs mixture to mouse ears 20 min prior to each TPA application once a day for 4 days inhibited TPA-induced persistent inflammation, as well as TPA-induced increase in IL-1beta and IL-6 protein levels. TFs also inhibited arachidonic acid (AA) metabolism via both cyclooxygenase (COX) and lipoxygenase pathways, according to “Inhibitory effects of black tea theaflavin derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and arachidonic acid metabolism in mouse ears” byHuang MT, Liu Y, Ramji D, Lo CY, Ghai G, Dushenkov S, Ho CT.(55).

4. Myricetin is a flavonol, belong to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. It has been used as antioxidant to lower cholesterol, treat certain types of cancer, etc.
a. Antioxidant and cytotoxic activity
In the evaluation of extracted from plants containing phenolic compound, including flavonoid-galloyl glycoside [myricetin 3-O-(2',3'4'-tri-O-galloyl)-α-l-rhamnopyranoside] and theirs antioxidant and cytotoxic effect found that the methanol extract exhibited high antioxidant activity (SC(50) = 3.94 µg/ml), which is correlated with its phenolic content. The extract also showed cytotoxic activity against Hep G2 (IC(50) value 1.41 µg/ml) confirming its anticancer activity against hepatocellular carcinoma, according to the study of “Antioxidant and cytotoxic activity of polyphenolic compounds isolated from the leaves of Leucenia leucocephala” by Haggag EG, Kamal AM, Abdelhady MI, El-Sayed MM, El-Wakil EA, Abd-El-Hamed SS.(56)
b. Antitumour and anti-inflammatory activities
In the observation of of flavonoids isolated from Byrsonima crass and its effect on mammary tumour cells LM2, found that almost all the samples showed inhibitory activity to the release of NO but not of TNF-alpha. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities, according to “Isolated flavonoids against mammary tumour cells LM2″ by Carli CB, de Matos DC, Lopes FC, Maia DC, Dias MB, Sannomiya M, Rodrigues CM, Andreo MA, Vilegas W, Colombo LL, Carlos IZ.(57).

5. Cyanidin is an anthocyanins (flavonals), in the group of Flavonoids (polyphenols), found abundantly in red apple and pear, bilberry, blackberry, blueberry, cherry, cranberry, peach, plum, hawthorn, etc.
a. Antioxidants
In the verification of the chemical properties included composition of anthocyanins and other polyphenols, antioxidant activity and profiles of antioxidants by HPLC post-column derivatization or TLC of Polish cultivars of blue-berried honeysuckles (Lonicera caerulea L.), wild and bog bilberr, found that The antioxidant activity of different blue-berried honeysuckle cultivars was similar to that of wild growing bilberries (range from 170 to 417 μmol TE/g dm in ABTS and from 93-166 μmol TE/g dm in DPPH and Folin-Ciocalteu tests). The major anthocyanin in the blue-berried honeysuckle was cyanidin-3-glucoside that constituted 84-92% of the total anthocyanins. The TLC and HPLC post-column antioxidant profiles indicated that anthocyanins are the major antioxidants in all berries studied, according to “Phenolic Composition and Antioxidant Properties of Polish Blue-Berried Honeysuckle Genotypes by HPLC-DAD-MS, HPLC Post-Column Derivatization with ABTS or FC, and TLC with DPPH Visualization” by Kusznierewicz B, Piekarska A, Mrugalska B, Konieczka P, Namiesnik J, Bartoszek A (58)
b. Anti-inflammatory Effects
In the investigation of the cartilage-protecting and anti-inflammatory effects of a polyphenolic-enriched red raspberry extract (RRE; standardized to total polyphenol, anthocyanin, and ellagitannin contents), found that On treatment with RRE (50 μg/mL), there was a decrease in the rate of degradation of both proteoglycan and type II collagen. In the in vivo antigen-induced arthritis rat model, animals were gavaged daily with RRE (at doses of 30 and 120 mg/kg, respectively) for 30 days after adjuvant injection (750 μg of Mycobacterium tuberculosis suspension in squalene). At the higher dose, animals treated with RRE had a lower incidence and severity of arthritis compared to control animals, according to “Anti-inflammatory Effects of Polyphenolic-Enriched Red Raspberry Extract in an Antigen-Induced Arthritis Rat Model” by Jean-Gilles D, Li L, Ma H, Yuan T, Chichester CO, Seeram NP.(59)
c. Obesity
In the demonstration of Cyanidin-3-O-β-glucoside (Cy-3-g)-rich foods have been reported to inhibit the onset of obesity, found that Cy-3-g improves obesity and triglyceride metabolism in KK-Ay mice. The underlying mechanism is found to be partly related to the activation of LPL in plasma and skeletal muscle, and inhibition of LPL in adipose tissue following the activation of pAMPK, according to “Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity” by Wei X, Wang D, Yang Y, Xia M, Li D, Li G, Zhu Y, Xiao Y, Ling W.(60).

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(47) http://www.ncbi.nlm.nih.gov/pubmed/20176036
(48) http://www.ncbi.nlm.nih.gov/pubmed/1284389
(49) http://www.ncbi.nlm.nih.gov/pubmed/10878235
(50) http://www.ncbi.nlm.nih.gov/pubmed/20156466
(51) http://www.ncbi.nlm.nih.gov/pubmed/22269864
(52) http://www.ncbi.nlm.nih.gov/pubmed/22256752
(53) http://www.ncbi.nlm.nih.gov/pubmed/21887850
(54) http://www.ncbi.nlm.nih.gov/pubmed/16496576
(55) http://www.ncbi.nlm.nih.gov/pubmed/16404705
(56) http://www.ncbi.nlm.nih.gov/pubmed/21595573
(57) http://www.ncbi.nlm.nih.gov/pubmed/19323263
(58) http://www.ncbi.nlm.nih.gov/pubmed/22264130
(59) http://www.ncbi.nlm.nih.gov/pubmed/22111586
(60) http://www.ncbi.nlm.nih.gov/pubmed/21360538

Wednesday, October 14, 2015

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoporosis Prevention - The combined antioxidants and antioxidants

By Kyle J. Norton(Scholar)
Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

Generalized partial linear model (GPLM) is found to be effective in determining nonlinear effects of an important continuous-scale risk factor. The final GPLM model shows that TCM symptoms play an important role in assessing the risk of osteoporosis. The GPLM also reveals a nonlinear effect of the important risk factor, menopause years, which might be missed by the generalized linear model.

1. In the study to evaluate whether antioxidant defenses are decreased in elderly osteoporotic women and, if this is the case, to understand whether osteoporosis is a condition characterized by increased oxidative stress, researchers at the Gerontology and Geriatrics, University of Perugia, found that dietary and endogenous antioxidants were consistently lower in osteoporotic than in control subjects. On the other hand, plasma levels of malondialdehyde, a byproduct of lipid peroxidation, did not differ between groups. Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation(32).

2. Selenium plus vitamins E and C
In the study to to investigate the effect of heparin on osteoporosis initiation, and the effect of selenium plus vitamins E and C, and the sole combination of vitamins E and C on the progress of osteoporosis induced by heparin through histologic means, showed that the combination of vitamins E and C given to the experimental rabbits partially prevented this bone tissue destruction. When sodium selenite was given together with vitamins E and C to the osteoporosis model rabbits, the long bone tissue had almost the same structure as in normal rabbits, for example the development of numerous bone trabeculae(33).

3. Vitamin C
According to the study epidemiologic studies correlate low vitamin C intake with bone loss. The genetic deletion of enzymes involved in de novo vitamin C synthesis in mice, likewise, causes severe osteoporosis. In the study of Vitamin C prevents hypogonadal bone loss by School of Stomatology, Wuhan University, Wuhan indicated that the ingestion of vitamin C prevents the low-turnover bone loss following ovariectomy in mice. This prevention in areal bone mineral density and micro-CT parameters results from the stimulation of bone formation, demonstrable in vivo by histomorphometry, bone marker measurements, and quantitative PCR. Notably, the reductions in the bone formation rate, plasma osteocalcin levels, and ex vivo osteoblast gene expression 8 weeks post-ovariectomy are all returned to levels of sham-operated controls(34).

4. Calcium and vitamin D
Calcium supplements reduce the rate of bone loss in osteoporotic patients. Some recent studies have reported a significant positive effect of calcium treatment not only on bone mass but also on fracture incidence. The SENECA study, has also shown that vitamin D insufficiency is frequent in elderly populations in Europe. There are a number of studies on the effects of vitamin D supplementation on bone loss in the elderly, showing that supplementations with daily doses of 400-800 IU of vitamin D, given alone or in combination with calcium, are able to reverse vitamin D insufficiency, to prevent bone loss and to improve bone density in the elderly, according to the Dr. Gennari C. by Institute of Internal Medicine, University of Siena(35)
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/7864688
(32) http://www.ncbi.nlm.nih.gov/pubmed/12679433
(33) http://www.ncbi.nlm.nih.gov/pubmed/14677021
(34) http://www.ncbi.nlm.nih.gov/pubmed/23056580
(35) http://www.ncbi.nlm.nih.gov/pubmed/11683549

Tuesday, October 13, 2015

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoporosis Prevention - The antioxidants

By Kyle J. Norton(Scholar)
Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

1. Free Radicals scavengers (Immune system and functioning)
Free Radicals play an important role in the function of the Immune System. The immune systen produce free radicals to kill foreign microbes, but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals that stimulate the formation of more free radicals, leading to even more damage, until they are brought to stop.
a. Vitamin A
vitamin A plays an essential roles in enhancing a broad range of immune processes, including lymphocyte activation and proliferation, T-helper-cell differentiation, the production of specific antibody isotypes and regulation of the immune response.
b. Vitamin C
Researchers found that vitamin C raised the concentration in the blood of immunoglobulin A, M that promotes the ability of antibodies and phagocytic cells to clear pathogens.
c. Vitamin E
In aged mice study showed that Vitamin E beside increased both cell-dividing and IL-producing capacities of naive T cells it also enhances the immune functions in association with significant improvement in resistance to influenza infection.
d. Zinc
Zinc, as a antioxidant is essential mineral in ading immune system by enhancing the proper function of T cells which belong to a group of white blood cells known as lymphocytes, in fighting against damaging free radicals.
2. Antioxidants and osteoarthritis
a. Vitamin E and fish oil
In genetically altered mice study, researcher found that diet included fish oil plus vitamin E significantly reduce the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum.
b. Glucosamine
Since glucosamine, a compound of the simple sugar glucose and the amino acid glutamine, is a precursor for glycosaminoglycans, and they are a major component of joint cartilage. Study found that supplemental glucosamine may help to prevent cartilage degeneration and treat arthritis.
c. DLPA (dl- phenylalanine)
DLPA, a mixture of D-Phenylalanine and L-Phenylalanine, is a nutritional supplement amino acid. Researchers found that DLPA effectively reduces arthritis pain and joint inflammation in many patients.
d. Glucosamine and Methylsulfonylmethane
In a double-blind, placebo-controlled study with osteoarthritis of the knee were given a combination of glucosamine and MSM, or placebo. After 12 weeks, the results suggested combination of MSM and glucosamine may improve arthritis symptoms as compared to placebo.

3. Etc..


1000 top Paleo Recipes
The Natural Way to Make Delicious, Healthy,
Fat-Burning Paleo Recipes Quickly And Easily


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sunday, October 11, 2015

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoporosis Prevention Diet

By Kyle J. Norton(Scholar)
Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

The Diet
1. Green tea
In the study to investigate whether black tea polyphenol, theaflavin-3,3′-digallate (TFDG) and green tea, epigallocatechin-3-gallate (EGCG)affect MMP activity and osteoclast formation and differentiation in vitro, showed that TFDG and EGCG inhibited the formation and differentiation of osteoclasts via inhibition of MMPs. TFDG may suppress actin ring formation more effectively than EGCG. Thus, TFDG and EGCG may be suitable agents or lead compounds for the treatment of bone resorption diseases(1).

2. Organic Soy
In the study to clarify the effect of ingesting soy isoflavone extracts (not soy protein or foods containing isoflavones) on bone mineral density (BMD) in menopausal women, found that the varying effects of isoflavones on spine BMD across trials might be associated with study characteristics of intervention duration (6 vs. 12 months), region of participant (Asian vs. Western), and basal BMD (normal bone mass vs. osteopenia or osteoporosis). No significant effects on femoral neck, hip total, and trochanter BMD were found. Soy isoflavone extract supplements increased lumbar spine BMD in menopausal women(2).

3. Orange juice
In the study to evaluate the possible variations in antioxidant enzymes, lipid peroxidation and erythrocyte deformability in experimentally induced osteoporosis in female rats and to assess the effects of vitamin C supplementation on those variations, indicated that BMD was significantly lower in the group O than in the group C (p = 0.015), whereas it was significantly higher in the group OVC than in the group O (p = 0.003). MDA activity was significantly higher in the group O than in the group C (p = 0.032), whereas it was significantly lower in the group OVC than in the group O (p = 0.025). SOD activity was significantly higher in the group O than in the group C (p = 0.032). Erythrocyte deformability was significantly higher in the group O than in the group C and OVC (p = 0.008, p = 0.021, respectively)(3).

4. Milk thistle seeds
In the study to investigate that silibinin had bone-forming and osteoprotective effects in in vitro cell systems of murine osteoblastic MC3T3-E1 cells and RAW 264.7 murine macrophages, found that that silibinin retarded tartrate-resistant acid phosphatase and cathepsin K induction and matrix metalloproteinase-9 activity elevated by RANKL through disturbing TRAF6-c-Src signaling pathways. These results demonstrate that silibinin was a potential therapeutic agent promoting bone-forming osteoblastogenesis and encumbering osteoclastic bone resorption(4).

5. Skin and seed of grape
In the study to investigate the molecular mechanism of how resveratrol can modulate the lineage commitment of human mesenchymal stem cells to osteogenesis other than adipogenesis, showed that
resveratrol promoted spontaneous osteogenesis but prevented adipogenesis in human embryonic stem cell-derived mesenchymal progenitors. Resveratrol upregulated the expression of osteo-lineage genes RUNX2 and osteocalcin while suppressing adipo-lineage genes PPARγ2 and LEPTIN in adipogenic medium. Furthermore, the osteogenic effect of resveratrol was mediated mainly through SIRT1/FOXO3A with a smaller contribution from the estrogenic pathway(5).

Saturday, October 10, 2015

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoporosis: The Diagnosis and Complications

By Kyle J. Norton(Scholar)

Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

III. Diagnosis
According to the Clinical practice guidelines for the diagnosis and management of osteoporosis. Scientific Advisory Board, Osteoporosis Society of Canada, Screening and diagnostic methods: risk-factor assessment, clinical evaluation, measurement of bone mineral density, laboratory investigations.

If you are experience certain symptom of osteoporosis, the tests which your doctor order include
1. Blood and urinary tests
The aim of the tests are to check for the bone metabolism and the progression of bone (loss) diseases.

2. Dual energy X-ray absorptiometry (DXA)
Dual energy X-ray absorptiometry (DXA) is one most common test to measure the total bone density of including spine, hip, wrist etc. with accurate result.
3. Quantitative Ultrasound and computed tomography (QCT)
The evaluation of bone density at the lumbar spine and hip.using a standard X-ray Computed Tomography (CT) scanner. Quantitative ultrasound (QUS), a technology
for measuring properties of bone at peripheral skeletal sites, is more portable and less expensive than DXA, without the use of ionizing radiation(23).
Dr. Riggs BL and the research team in the study of Better tools for assessing osteoporosis indicated that a whole new field of research into the determinants of bone loss and fractures in the axial skeleton and set the stage for subsequent development of dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT), which are now the standard methods for assessing osteoporosis severity and treatment efficacy(24), but other study found that in cross-sectional study of males with glucocorticoid-induced osteoporosis (GIO, quantitative computed tomography (QCT), High-resolution quantitative computed tomography (HRQCT)-based measurements and finite element analysis (FEA) variables were superior to DXA in discriminating between patients of differing prevalent vertebral fracture status(25).
4. Etc.

IV. Complication associated with Osteoporosis
Pain, Fractures, Vertebral, Wrist, Rib fractures are associated with Osteoporosis, according to the study of New advances in imaging osteoporosis and its complications, said “We, as clinicians, should aim to increase awareness of this fracture type both as a frequent and varied source of pain in patients with osteoporosis and as the ultimate marker of severely impaired bone strength.”(26)

1000 top Paleo Recipes
The Natural Way to Make Delicious, Healthy,
Fat-Burning Paleo Recipes Quickly And Easily


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources

(a) http://www.ncbi.nlm.nih.gov/pubmed/7864688
(23) http://www.iscd.org/visitors/pdfs/10-QuantitativeUltrasoundintheMgmtofOsteo.pdf
(24) http://www.ncbi.nlm.nih.gov/pubmed/23154276
(25) http://www.ncbi.nlm.nih.gov/pubmed/23149277
(26) http://www.ncbi.nlm.nih.gov/pubmed/22618377