Tuesday, August 30, 2016

Children Health: Attention Deficit Disorder (ADHD/ADD) -Treatments In Herbal medicine perspective - Gotu Kola

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

           Attention Deficit Disorder (ADHD/ADD)

Attention Deficit Disorder (ADHD/ADD) also known as attention deficit hyperactivity disorder is a chronic disease occurs in certain age and years of a children, defined as a condition with characteristics of co-existence of attentional problems and hyperactivity. It effects about 5% of the all children in the world with boys have 3-4 times higher risk than girl. Over one third of children with ADHD will have continued symptoms existed into their adult life.


                 The Herbal medicine - Gotu Kola

 a. Locomotor activity
In the investigation of the asiatic acid, a triterpenoids isolated from Centellaasiatica and its inhibitory effect on acetylcholinesterase (AChE) properties, excitatory post synaptic potential (EPSP) and locomotor activity. found that asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor, according to "Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synapticpotential and locomotor activity" by Nasir MN, Abdullah J, Habsah M, Ghani RI, Rammes G.(78)

b. Cognitive effects
In the assessment of the role of "Brahmi" (Bocopa monnieri and Centella asiatica) and its effect on the loss of memory, cognitive deficits, impaired mental function found that both plants possess neuroprotective properties, have nootropic activity with therapeutic implications for patients with memory loss. The field has witnessed exciting patent activity with most inventions aiming at either (i) improving the methods of herbal extraction or (ii) enrichment and purification of novel compounds from brahmi or (iii) providing novel synergistic formulations for therapeutics in various human ailments, according to "Exploring the role of "Brahmi" (Bocopa monnieri and Centella asiatica) in brain function and therapy" by Shinomol GK, Muralidhara, Bharath MM.(79)

c. Antioxidant capacity
In the identification of antioxidant effects of C. asiatica was exposed to various fermentations: no fermentation (0 min), partial fermentation (120 min) and full fermentation (24 h). Total phenolic content (TPC) and ferric-reducing antioxidant power (FRAP) of C. asiatica, found that C. asiatica herbal teas should be prepared at 100 °C for 10 min to obtain the optimum antioxidant capacity. Multiple brewing steps in C. asiatica herbal tea are encouraged due to the certain amount of antioxidant obtained, according to "Antioxidant capacity and phenolic composition of fermented Centella asiatica herbal teas" by Ariffin F, Heong Chew S, Bhupinder K, Karim AA, Huda N.(80)

d. Etc.
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Dietary Minerals Calcium: Neuronal calcium homeostasis in the aging nervous system

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                      Calcium

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

  Neuronal calcium homeostasis in the aging nervous system

 Numerous studies indicate various disturbances of the Ca2+ homeostasis on different levels like Ca2+ channel properties, 45Ca2+ uptake, or Ca2+ binding proteins. Investigations on alterations of the free intracellular calciumconcentration ([Ca2+]i) in presynaptic synaptosomal preparations led to inconsistent results reporting increased or unchanged [Ca2+]i in aged animals, according to the Central Institute of Mental Health, Dept. Psychopharmacology(11).
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Monday, August 29, 2016

Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Lou Lu (Radix Stemmacanthae)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
           Lou Lu (Radix Stemmacanthae)


Lou Lu is also known as Uniflower Swiss centaury. The bitter and cold herb has been used in TCM to treat boils, carbuncles, acute mastitis, unable to discharge milk, etc., as it clears Heat, expels toxins, resolves abscesses and edema, promotes lactation, etc., by enhancing the stomach channel.

Ingredients
1. Erythro-centaurin
2.Crystalline
3. Non-nitrogenous
4. Glucoside
5. Erytaurin
6. Valeric acid
7. Etc.

Health Benefits
1. Anti cancers
In the study of Two new thiophenes, 5-{4-[4-(5-pent-1,3-diynylthiophen-2-yl)-but-3-ynyloxy]-but-1-ynyl}-2,2′-bithiophene (1) and 5-(4-hydroxybut-1-one)-2,2′-bithiophene (2), together with two known thiophenes 5-(4-hydroxybut-1-ynyl)-2,2′-bithiophene (3) and 5-(3,4-dihydroxybut-1-ynyl)-2,2′-bithiophene (4), isolated from the roots of Echinops latifolius Tausch, found that Compounds 1 and 2 showed significant inhibition activities against human cancer cell lines A375-S2 and HeLa with IC(50) values from 3.1 to 13.5 micromol/L, depending on their exposure to long wavelength ultraviolet light(1)
2. Hepatocyte necrosis and functional disorder
In the study to compare the protective effect with “Lou-lu” derived from the root of E. latifolius Tausch and “Pei-chai-hu” original Bupleurum chinense showed that E. grijisii and E. latifolius were more effective than B. chinense as reported previously and suggested that both E. grijisii and E. latifolius could correct the hepatocyte necrosis and functional disorder induced by the CCl4 treatment(2)
3. Etc.

Side effects
1. Do not use in cases of Qi deficiency or boils being flat or collapsed and in pregnancy
2. Do not use the Herb in newborn, children or if you are pregnant or
breast feeding with out approval first with the related field specialist



Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/17564953
(2) http://www.ncbi.nlm.nih.gov/pubmed/2270845



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General Health: Cirrhosis - Treatment of the complications of cirrhosis - Hepatic encephalopathy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                   Cirrhosis 

Cirrhosis is defined as a condition of irreversible scarring liver as a result of liver tissue by fibrosis due to final phase of chronic liver diseases of that can lead to poor function of the liver and liver failure. According to the statistics, Number of discharges with chronic liver disease or cirrhosis as the first-listed diagnosis: 101,000 in 2009 and Deaths per 100,000 population: 10.3 in 2010(a). Hepatitis B infection cause of the disease is very prevalent in South-East Asia.

               The Treatments


A. Treatments of cirrhosis depend not on the underline causes and stage of the diseases
Treatment of the complications of cirrhosis - Hepatic encephalopathy

Hepatic encephalopathy a condition of liver failure causes of confusion, altered level of consciousness, and coma.
A.2.4.1. In conventional medicine
1. Antibiotics
In the study to test Prominent antibiotics such as neomycin, metronidazole, vancomycin and rifaximin for the treatment of hepatic encephalopathy (HE), showed that despite its cost in the US, rifaximin may prove cost-saving by preventing hospitalizations for overt HE. In minimal/covert HE, rifaximin is the only systematically studied antibiotic. Rifaximin showed improvement in cognition, inflammation, quality-of-life and driving simulator performance but cost-analysis does not favor its use at the current time. Antibiotics, especially rifaximin, have a definite role in the management across the spectrum of HE.
However the limited numbers studied, adverse effects (neomycin oto- and nephrotoxicity, metronidazole neurotoxicity) and potential for resistance emergence (vancomycin-resistant enterococcus) has limited the use of most antibiotics, apart from rifaximin which has the greatest evidence base(97).

2. Combination therapy
In the study to evaluate the efficacy and safety of combination therapy for thetreatment and prevention of hepatic encephalopathy (HE), showed that he evidence evaluating the use of combination therapy for the treatment of HE does not support its widespread use. The combination of rifaximin and lactulose may be considered in the treatment of HE and in patients refractory to monotherapy. The combination of rifaximin and lactulose should be considered for the prevention of HE, especially after the second episode of HE recurrence(98).

3. L-ornithine-L-aspartate (LOLA)
L-Ornithine-L-aspartate (LOLA) has been shown to reduce ammonia and improve psychometric function in patients with hepatic encephalopathy. In the study to assess the effect of LOLA in healthy patients with cirrhosis and no evidence of clinical encephalopathy after challenging the central nervous system by administration of oral glutamine, found that LOLA ameliorated the deleterious psychometric effects of glutamine in Child's grade B and C patients with cirrhosis without TIPS and supports its use in clinical practice in hepatic encephalopathy(99).

A.2.4.2. In herbal medicine
Morin is a bioflavonoid, a constituent of many herbs and fruits that are used as herbal medicines and also several biological activities. According to the study byAnnamalai University, oxidative stress was effectively modulated by morin administration. Morin significantly improved the status of antioxidants and decreased the levels of ammonia, urea, TBARS, HP and liver markers enzymes, as compared to the AC-treated group. There is an evidence for the antihyperammonaemic, hepatoprotective and antioxidant effects of morin against oxidative stress induced by AC(100).

A.2.4.1. In traditional Chinese medicine
In the study to evaluate the efficacy, safety and recent survival rates of high-doseherbs Qingre Huayu with the function of clearing heat and resolving stasis, in patients with hepatitis B-related ACLF with heat toxin stagnation syndrome, found that high doses of Qingre Huayu herbs can significantly improve liver function and coagulation function, reduce complications, and reduce mortality in patients with hepatitis B-related ACLF(101).

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Sources
(a) http://www.cdc.gov/nchs/fastats/liverdis.htm
(97) http://www.ncbi.nlm.nih.gov/pubmed/23389621
(98) http://www.ncbi.nlm.nih.gov/pubmed/23092866
(99) http://www.ncbi.nlm.nih.gov/pubmed/10986219
(100) http://www.ncbi.nlm.nih.gov/pubmed/18756351
(101) http://www.ncbi.nlm.nih.gov/pubmed/22313885
(102) http://www.ncbi.nlm.nih.gov/pubmed/23372315



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Overcome Infertility: Hemizona Assay of Male Infertility In Conventional medicine Perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Overcome Infertility 

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.

       Hemizona Assay of  Male Infertility In Conventional medicine Perspective

I. Definition
Hemizona assay is an analysis to compare the binding capacity of sample sperm of the unfertilized male to the sperm of the fertilized male through manual hand cutting versus micro manipulation in IVF and IUI fertilization.


II. Diagnosis
After splitting the mature and normal egg in half. 1/2 is tested by sample sperm of the infertile male and the other half is tested by the fertilized male sperm through manual hand cutting or micro manipulation. Then the number of sperm bounds to each half and is calculated, and the infertile male's sperm is divided by that from the fertile male's sperm. A figure of less than 0.60 indicates abnormal infertile male's sperm.

Although the success rate of this test is not 100%, the HZA has been found to be predictive of IVF and IUI outcome with positive and negative values of 83% and 95% respectively, according to one study. Therefore, if an infertile couple decides to go through IUI or IVF for conception then the hemizoma test is necessary.

III. Risk
There is no guarantee that a couple who scores high in the hemizoma test will be successful to conceive via IVF or IUI, because there are other factors that may interfere with the process after the fertilized egg or embryo was implanted into the uterus.
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Phytochemicals for Treatment of Cervical Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.

                        Cervical Cancer 

Cervix is the lower part of uterus that opens at the top of the vagina. Cervix acts an transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus. Cervical cancer is malignantneoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

II. Pre-cervical cancer
Precervical cancer is the early stage of abnormal cell changes in the cervical tissue, if left untreated, it can develop into true invasive cervical cancer caused by factors connected to male seminal fluid. A vaccine, Gardasil used to prevent pre-cervical cancer from the infection of two types of HPV was approved by the U.S. Food and Drug Administration in 2006. It is for your benefits to take this vaccine if you are sexual active with several partners.

III. Types of Food to Prevent and Treat Cervical Cancer
1. Black raspberry
Black raspberries and their derivatives, have demonstrated a marked ability to inhibit preclinical models of epithelial cancer cell growth and tumor formation. Dr. Zhang Z and the research team at the The Ohio State University, Columbus, showed that non-toxic levels of RO-ET significantly inhibited the growth of humancervical cancer cells, in a dose-dependent and time-dependent manner to a maximum of 54%, 52% and 67%, respectively (p<0.05). Furthermore, cell growth inhibition was persistent following short-term withdrawal of RO-ET from the culture medium. Flow cytometry and fluorescence microscopy demonstrated RO-ET-induced apoptosis in all cell lines(1).

2. Green and Black Tea
Phytochemicals present in tea, particularly polyphenols, have anticancer properties against several cancer types. In the study to investigate the mechanism of antiproliferative and apoptotic actions exerted by tea polyphenols on human papilloma virus-18-positive HeLa cervical cancer cells, showed that treatment of green tea polyphenol (-)-epigallocatechin gallate (EGCG) and black tea polyphenol theaflavins (TF) in HeLa cells showed a marked concentration- and time-dependent inhibition of proliferation and induced sub-G1 phase in a dose-dependent manner after 24 h. There was an attenuation of mitochondrial membrane potential with the increase of reactive oxygen species generation, p53 expression, Bax/Bcl-2 ratio, cytochrome-c release, and cleavage of procaspase-3 and -9 and poly(ADP-ribose)-polymerase, indicating the participation of a mitochondria related mechanism. In addition, EGCG as well as TF inhibited activation of Akt and nuclear factor-kappaB (NF-kappaB) via blocking phosphorylation and subsequent degradation of inhibitor of kappaBalpha and kappaBbeta subunits, thereby downregulating cyclooxygenase-2(2).
Flavonoid quercetin found abundantly in green and black tea are associated with cell proliferation and apoptosis. Dr Vidya Priyadarsini R, and the research team at the Annamalai University, in the study of The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-ÎşB inhibition, indicated that quercetin suppressed the viability of HeLa cells in a dose-dependent manner by inducing G2/M phase cell cycle arrest and mitochondrial apoptosis through a p53-dependent mechanism. This involved characteristic changes in nuclear morphology, phosphatidylserine externalization, mitochondrial membrane depolarization, modulation of cell cycle regulatory proteins and NF-ÎşB family members, upregulation of proapoptotic Bcl-2 family proteins, cytochrome C, Apaf-1 and caspases, and downregulation of antiapoptotic Bcl-2 proteins and survivin(3)

3. Epigallocatechin gallate from Tea, Curcumin from curry and Soyaisoflavones
Epidemiological and preclinical evidence suggests that polyphenolicphytochemicals exemplified by epigallocatechin gallate from tea, curcumin from curry and soya isoflavones possess cancer chemopreventive properties. Dr. Thomasset SC and scientists at the University of Leicester, in the review of above showed that the available evidence for tea polyphenols tentatively supports their advancement into phase III clinical intervention trials aimed at the prevention of progression of prostate intraepithelial neoplasia, leukoplakia or premalignantcervical disease. In the case of curcumin and soya isoflavones more studies in premalignacies seem appropriate to optimise the nature and design of suitable phase III trials. The abundance of flavonoids and related polyphenols in the plant kingdom makes it possible that several hitherto uncharacterised agents with chemopreventive efficacy are still to be identified, which may constitute attractive alternatives to currently used chemopreventive drugs(4).

4. Skins of grape and red wine
Resveratrol, a polyphenol found a abundantly in skins of grapes and red wine has been shown to significantly alter the cellular physiology of tumor cells, as well as block the process of initiation and progression, some studies found that tumor cells may exhibit changes in the cellular response to IR following exposure toresveratrol, a naturally occurring compound that inhibits cyclooxygenase-1 (COX-1) activity. Thus, clonogenic cell survival assays were performed using irradiated HeLa and SiHa cells pretreated with resveratrol prior to IR exposure, and resulted in enhanced tumor cell killing by IR in a dose-dependent manner(5).

5. Milk thistle seeds
Silibinin, an effective anti-cancer and chemopreventive agent in various epithelialcancer models, found abundantly in milk thistle seed has been reported to inhibitcancer cell growth through mitogenic. Dr. Zhang Y, and research team at Life Science College, Jilin University, in the study of Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells, indicated that silibinin showed a dose-dependent and a time-dependent apoptotic death in HeLa cells in both the mitochondrial pathway and the death receptor-mediated pathway, providing a strong rationale for future studies evaluating preventive and/or intervention strategies for silibinin in cervical cancer pre-clinical models(6).

6. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21831414
(2) http://www.ncbi.nlm.nih.gov/pubmed/21776820
(3) http://www.ncbi.nlm.nih.gov/pubmed/20858478
(4) http://www.ncbi.nlm.nih.gov/pubmed/17131309
(5) http://www.ncbi.nlm.nih.gov/pubmed/11741744
(6) http://www.ncbi.nlm.nih.gov/pubmed/22170400

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Women Health: Menstrual Disorders - Menorrhagia In Traditional Chinese medicine Perspective - The Herbal Treatments of Liver blood deficiency

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Menorrhagia is defined as a condition of excessive bleeding in the menstruation phase of the menstrual cycle in the reproductive age of a woman leading to heavy blood loss that can interfere with the woman normal activities, as a result of disruption of normal hormonal regulation of periods or disorders of certain reproductive organs.
In traditional Chinese medicine, menorrhagia can be caused by combination of Spleen qi deficiency, liver blood deficiency, damp accumulation and treatments include Tonify spleen qi, nourish blood, resolve dampness.
Please note that in TCM, same disease may be treated with different formula and difference diseases may be treated with the same formula depending to the differentiation.


The Treatments - Herbs for Liver blood deficiency 



1. He shou wu (fleeceflower root)
He shou wu is a liver tonic herb. It promotes liver function in blood formation and increases the kidney qi in assisting the liver in transporting blood to the heart for circulation, thereby reducing the blood stagnation causes of deficiency. It also improves the kidney in urinary secretion, thus decreasing the risk of blood stagnation caused by fluid retention.

2. Shu Di Huang (Chinese foxglove root)
Shu di huang is a blood tonic herb. Besides improving the liver in blood formation, it also increases the liver's qi by boosting the circulatory system in transporting oxygen and nutrients to the body's cells thus reducing the risks of symptoms of dizziness, pallid complexion, palpitations, and scanty menstruation.

3. E Jiao (Donkey-Hide Glue)
E jiao is an important herb for improving the liver in blood formation and liver qi in regulating the blood circulation in the body thereby reducing the symptoms of dizziness, shallow complexion, and palpitations caused by blood deficiency.

4. Dang gui (Chinese angelica root)
Dang gui is best known for improving the liver's function in blood formation and regulating the function of the reproductive organs. It also harmonizes the production of hormones during the menstrual cycle, leading to reduced cramps and pain caused by blood deficiency and stagnation.

5. Bai shao (white peony root)
Bai shao plays an important role in nourishing the blood and regulating menstrual problems caused by blood deficiency. It also harmonizes the liver and spleen to prevent the rising of blood heat causes of headache and dizziness.
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