Medical Advisor Journals

Tuesday, August 30, 2016

Herbal therapy: Popular Herbal St John's wort (Hypericum perforatum)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

St John's wort (Hypericum perforatum)

St John's wort is a yellow flower plant in the genus Hypericum belonging to the family Hypericaceae, native to the regions of North America, Europe, Turkey, Russia, India, China and Brazil. The herb is best known fot its anti depression property and has been used in tradtional medicine as sedative agent to treat mental and cognitive disorders, including depression, anxiety, and/or sleep disorders and nerve pain, etc.

Health Benefits
1. Influenza A virus
In the assessment of efficacy of an extract of H. perforatum (HPE) against influenza A virus (IAV) in mice, found that HPE has significant therapeutic efficacy for mice infected with IAV. The possible reasons for these results were concluded to be pertaining to up-regulating the expression of IL-10 and IFN-γ, and down-regulating the secretion of IL-6 and TNF-α in lung and serum, according to "Therapeutic efficacy of Hypericum perforatum L. extract for mice infected with an influenza A virus" by Xiuying P, Jianping L, Ruofeng S, Liye Z, Xuehong W, Yan L.(1)

2. Inflammatory effects
In the evaluation of the impact of H. perforatum extract and the 4 compounds on inflammatory mediators and cytokines (SOCS1-4) found that the 4 compounds inhibited LPS-induced PGE2 and NO through SOCS3 activation. The reduction of PGE2 can be partially attributed to COX-2 enzyme activity, which was significantly elevated with SOCS3 knockdown. At the same time, these results also suggest that constituents in H. perforatum extract were alleviating LPS-induced macrophage response through SOCS3 independent mechanisms, according to "The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3" by Huang N, Rizshsky L, Hauck CC, Nikolau BJ, Murphy PA, Birt DF.(2)

3. Antidepressant
In the analyzing the effects of a chronic hyperforin of of the medicinal plantHypericum perforatum (St. John's wort).treatment on brain cell, found that Hyperforin stimulated the expression of TRPC6 channels and TrkB via SKF-96365-sensitive channels controlling a downstream signalling cascade involving Ca2+, protein kinase A, CREB and p-CREB. In vivo, hyperforin augmented the expression of TrkB in the cortex but not in the hippocampus where hippocampal neurogenesis remained unchanged. In conclusion, this plant extract acts on the cortical BDNF/TrkB pathway leaving adult hippocampal neurogenesis unaffected. This study provides new insights on the neuronal responses controlled by hyperforin, according to "The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner" by Gibon J, Deloulme JC, Chevallier T, Ladevèze E, Abrous DN, Bouron A.(3)

4. Antioxidant and antimicrobial activities
In the study of the fatty acid components of the hexane extracts of flower, leaf, stem, and seed of Hypericum scabrum, found that The antimicrobial activity of the extracts of those samples were determined against seven Gram-positive and Gram-negative bacteria (Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, S. epidermidis, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae), as well as three fungi (Candida albicans, Saccharomyces cerevisiae, and Aspergillus niger). The bioassay showed that the oil exhibited moderate antimicrobial activity. This study reveals that the all parts of this plant are attractive sources of fatty acid components, especially the essential ones, as well as of effective natural antioxidants, according to "Antioxidant, antimicrobial activities and fatty acid components of flower, leaf, stem and seed of Hypericumscabrum" by Shafaghat A.(4)
5. Sleep deprivation-induced anxiety-like behavior and oxidative damage
In the exploration of the therapeutic potential of Hypericum perforatum (St. John'swort) on behavioral alterations and oxidative damage induced by sleep deprivation in mice found that Co-administration of John's wort (200 mg/kg, P. O.) with imipramine (10 mg/kg, I. P.) further improved body weight, locomotor activity, antianxiety effect as well as reduced oxidative damage in sleep-deprived animal as compared to their effect per se (P < 0.05). The present study suggests that there is therapeutic potential of St. John's wort in the management of sleep deprivation-induced anxiety-like behavior and oxidative damage."Protective effect of St.John's wort (Hypericum perforatum) extract on 72-hour sleep deprivation-induced anxiety-like behavior and oxidative damage in mice" by Kumar A, Singh A.(5)

6. Insulin resistance
In the identification of St. John's Wort (SJW) extracts as inhibitors of adipogenesis of 3T3-L1 cells and demonstrated the effect against insulin-sensitive glucose uptake in mature fat cells.
found that the profound effects of SJW on adipogenesis, IRS-1 activation, and insulin-stimulated glucose uptake are not mediated by HI and/or HF. Nonetheless, we propose that extracts of SJW may contribute to adipocyte related diseases by limiting differentiation of preadipocytes and significantly inducing insulin resistance in mature fat cells, according to "St. John's Wort inhibits insulin signaling in murine and human adipocytes" by Richard AJ, Amini ZJ, Ribnicky DM, Stephens JM.(6)

7. Antimicrobial properties
In demonstration the antimicrobial properties of Hypericum, found that Hypericumprolificum, and Hypericum punctatum as inhibitors of bacterial growth and biofilm production. Assays were conducted against Staphylococcus epidermidis, Staphylococcus aureus, clinical methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii. Five of the seven compounds demonstrated growth inhibition against the Gram-positive bacteria with minimum inhibitory concentrations (MIC) ranging from 1.95 µg/mL to 7.81 µg/mL, according to "Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp" by Sarkisian SA, Janssen MJ, Matta H, Henry GE, Laplante KL, Rowley DC.(7)

8. Neuroprotective effects
In the observation of the neuroprotective effects and mechanism of hyperin on CoCl2-induced hypoxic/ischemic PC12 cells, found that Hyperin could inhibit CoCl2-induced cytotoxicity and apoptosis on PC12 cells, show neuroprotective effects on hypoxic/ischemic neural injuries, according to "[Protective effects and mechanism of hyperin on CoCl2-induced PC12 cells].[Article in Chinese]" by Zeng K, Wang X, Fu H, Liu G.(8)

9. Hypolipidemic and Antiobesity-Like Activity
In the investigation of the effect of Hypericum perforatum in a battery of animal models for metabolic disorder, found that Hypericum significantly lowered total cholesterol and low-density cholesterol in normal rats. Hypericum significantly inhibited weight gain in high-fat-fed rats. In fructose-fed rats, Hypericum normalised the dyslipidemia induced by fructose feeding and improved the insulin sensitivity, according to "Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats" by Husain GM, Chatterjee SS, Singh PN, Kumar V.(9)
10. Malignant gliomas (Aggressive brain tumor)
In the determination of the efficacy of p38SJ, a novel member of the DING family of proteins, derived from Hypericum perforatum calluses, on the growth of malignant glioma cell lines,
found that p38SJ reduces glioma cell viability and arrests cell cycle progression at G0/G1. The observed growth inhibitory effect of p38SJ is likely mediated by the downregulation of several cell cycle gatekeeper proteins, including cyclin E, Cdc2, and E2F-1, according to "Growth inhibition of malignant glioblastoma by DING protein" by Bookland MJ, Darbinian N, Weaver M, Amini S, Khalili K.(10)

11. Menopausal symptoms
In the study of the sample included 59 menopausal women who had the conditions for entering into the study. The individuals were selected via simple sampling and were assigned randomly into two groups of Hypericum Perforatum treatment group (30 women) and Passion Flower group (29 women), concluded that With regard to the effects of Hypericum Perforatum and Passion Flower on treating menopause precocious symptoms (vasomotor signs, insomnia, depression, anger, headache, etc.), these two herbs can be used as an alternative treatment for individuals who cannot, whatsoever, use hormone therapy, according to "A comparative study on the effects of Hypericum Perforatum and passion flower on the menopausal symptoms of women referring to Isfahan city health care centers' by Fahami F, Asali Z, Aslani A, Fathizadeh N.(11)

12. Etc.

Side effects
1. The herb may interact with other medicine, including anti depressants, birth control pills, anticoagulants, etc., please consult with your doctor if you are currently taking any types of prescription medicine(a)
2. Do not use the herb in new born, children, or if you are pregnant or breast feeding without approvals of the related field specialist.
3. Long term uses of St. John wort may increase the risk of iron and other minerals deficiency.
4. Overdoses can increase the risk of intermenstrual bleeding, delirium or mild serotonin
syndrome, etc.
5. The herb may cause certain side effects including headaches, stiff neck, nausea, vomiting, etc.
6. Etc.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Lu Tou (Semen Phaseoli radiati)

Lu Tou (Semen Phaseoli radiati)

Lu Tou is also known as Mung bean or Rice bean. The sweet, cold and non toxic herb has been used in TCM as antipyretic, diuretic and antidote for toxicity of arsenic, and poisons from plants or minerals agent and to treat edema, headache, etc., as it clears Heat, expels toxins, disperses Summer-Heat, etc., by enhancing the functions of heart and spleen channels

Ingredients
1. Protein
2. Fat
3. Carbohydrate
4. Fiber
5. Calcium
6. Iron
7. Magnesium
8. Phosphorus
9. Potassium
10. Selenium
11. Vitamin C
12. Phytosterols
13. Amino acids
14. Tryptophan
15. Threonine
16. Isoleucine
17. Leucine
18. Lysine
19. Methionine
20. Cystine
21. Phenylalanine
22. Tyrosine
23. Valine
24. Arginine
25. Histidine
26. Alanine
27. Aspartic acid
28. Glutamic acid
29. Glycine
30. Proline
31. Serine
32. Etc.

Health Benefits
1. Antioxidants
In the study to evaluate the AOA of cereals, millets, pulses and legumes, commonly consumed in India and assessed the relationship with their total phenolic content (TPC). AOA was assessed by DPPH (2,2-Diphenyl-1-picryl hydrazyl) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay and reducing power. Among cereals and legumes, Finger millet (Ragi) and black gram dhal (Phaseolus mungo Roxb) had the highest TPC, the values being 373 and 418 mg/100 g respectively, while rice (Oryza sativa) and green gram dhal (Phaseolus aureus Roxb) showed the least (47.6 and 62.4 mg/100 g). In the present study, FRAP (r = 0.91) and reducing power (r = 0.90) showed significant correlation with TPC in cereals and millets, but not in pulses and legumes(1).

2. Oxidative properties
In the investiagtion of the effects of kaempferol on the oxidative and phosphorylative properties of plant mitochondria from potato tubers and etiolated mung bean (Phaseolus aureus Roxb.) hypocotyls, showed that Kaempferol inhibited the state 3 oxidation rate of malate, NADH, and succinate, but was without effect on the ascorbate-tetramethyl p-phenylenediamine oxidation rate. The inhibition was almost the same whether the mitochondria were in state 3 or in an uncoupled state 3. When 180 micromolar kaempferol was added during state 4, the tight coupling of succinate or NADH oxidation was not released(2).

3. Etc.

Side Effects
1. Do not use the herb in Patient with weak digestion, chronic pain in the lower back with kidney deficiency
2. Do not use the herb in case of spleen deficiency
3. Etc.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19374263
(2) http://www.ncbi.nlm.nih.gov/pubmed/16662212

General Health: Cirrhosis - Treatments in Conventional Medicine - Cirrhosis Surgery

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Cirrhosis

Cirrhosis is defined as a condition of irreversible scarring liver as a result of liver tissue by fibrosis due to final phase of chronic liver diseases of that can lead to poor function of the liver and liver failure. According to the statistics, Number of discharges with chronic liver disease or cirrhosis as the first-listed diagnosis: 101,000 in 2009 and Deaths per 100,000 population: 10.3 in 2010(a). Hepatitis B infection cause of the disease is very prevalent in South-East Asia.

The Treatments

A. Treatments of cirrhosis depend not on the underline causes and stage of the diseases
Treatments in Conventional Medicine - Surgery

Liver transplant may be the best choice for some patients with chronic liver cirrhosis as it has been proven to improve the chances of long-term survival.
The main advantage of LDLT is the availability of an organ in the elective setting in the course of a progressive liver disease. This is most applicable in patients withCirrhosis and Hepatocellular carcinoma. LDLT, from the donor's perspective does carry a risk of not only morbidity but mortality. To date the surgical mortality risk is estimated at 0.1% for left lateral donation and 0.5% for right liver donation. There are reports of complications like Hepatic artery thrombosis, portal vein thrombosis and especially biliary leaks and strictures occurring at a significantly increased frequency after living as compared to deceased donor livertransplantation(102).

Overcome Infertility: Hormone Evaluation of Male Infertility In Conventional medicine Perspective

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.

Hormone Evaluation of Male Infertility In Conventional medicine Perspective

I. Definition
Hormonal evaluation is a study to measure the levels of certain hormones produced by your body such as levels of FSH and testosterone which are involved directly in sperm production. The test will only be used is the semen of sperm analysis come back with low density of sperm or your specialist suspects that hormone imbalance is the cause of infertility.

II. Procedure
Your fertilized special may order saliva test or blood spot test overall hormone assessment.

III. Analysis
Primary hormone imbalance effecting fertility happens only about 3% of infertile male, therefore if your doctor suspects that you have some symptom such as loss of muscle, enlarged breasts, low sexual desire, softer erections, weigh gain or loss, erectile dysfunction, low sperm density, etc., he or she may ask for male hormone imbalance test.
1. Testosterone
Testosterone decrease with age, testosterone deficiency is common in men over the age of 50. If the levels of testosterone is too low, it may causes sexual dysfunction ( most of the time he also has deficiency of kidney yang according to traditional Chinese herbalist) and symptoms of low density of sperm and sperm count and interferes with reproductive system in process of fertility.

2. Excess estrogen (estradiol)
Excess estrogen in male is rare, but it may happens. It causes symptoms such as hair loss, decreased libido, Increased urinary urge, prostate enlargement, weight gain and low sperm production and low sperm count that increases the risk of infertility.

3. Levels of FSH
FSH levels are important in production of sperm, if the levels of FSH is too high as resulting of primary testicular failure, it may interfere with sperm production and decrease sperm density and count.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Most Common Diseases of Ages of 50 Plus: Cancers - The Classification of Cancer

Cancers are classified by the types of cell that have become malignant.
1. Carcinoma
Carcinoma is a malignant tumor found in anywhere of epithelial tissues lining thecavities, surfaces of structures and glands. Although the forming of the malignant tumor in epithelium are still unknown, but it possesses and associates the characteristics of epithelial cells, including those of the breast, prostate, lung and colon.

2. Sarcoma
Sarcoma is a type of cancer that arises from malignantly connective tissue cells originated from embryonic germ cells or bone, cartilage, and fat tissues and cells.

3. Lymphoma and leukemia:
Hematopoietic cells are multipotent stem cells that give rise to all types of the blood cell, including red blood cells, white blood cells, and platelets become cancerous.

4. Germ cell tumor
Cancer derived from pluripotent cells. In adults these are most often found in the testicle and ovary, but are more common in babies and young children.

5. Blastoma
Cancer derived from immature "precursor" or embryonic tissue. These are also commonest in children.

Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Children Health: Attention Deficit Disorder (ADHD/ADD) -Treatments In Herbal medicine perspective - Gotu Kola

Attention Deficit Disorder (ADHD/ADD) also known as attention deficit hyperactivity disorder is a chronic disease occurs in certain age and years of a children, defined as a condition with characteristics of co-existence of attentional problems and hyperactivity. It effects about 5% of the all children in the world with boys have 3-4 times higher risk than girl. Over one third of children with ADHD will have continued symptoms existed into their adult life.

The Herbal medicine - Gotu Kola

a. Locomotor activity
In the investigation of the asiatic acid, a triterpenoids isolated from Centellaasiatica and its inhibitory effect on acetylcholinesterase (AChE) properties, excitatory post synaptic potential (EPSP) and locomotor activity. found that asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor, according to "Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synapticpotential and locomotor activity" by Nasir MN, Abdullah J, Habsah M, Ghani RI, Rammes G.(78)

b. Cognitive effects
In the assessment of the role of "Brahmi" (Bocopa monnieri and Centella asiatica) and its effect on the loss of memory, cognitive deficits, impaired mental function found that both plants possess neuroprotective properties, have nootropic activity with therapeutic implications for patients with memory loss. The field has witnessed exciting patent activity with most inventions aiming at either (i) improving the methods of herbal extraction or (ii) enrichment and purification of novel compounds from brahmi or (iii) providing novel synergistic formulations for therapeutics in various human ailments, according to "Exploring the role of "Brahmi" (Bocopa monnieri and Centella asiatica) in brain function and therapy" by Shinomol GK, Muralidhara, Bharath MM.(79)

c. Antioxidant capacity
In the identification of antioxidant effects of C. asiatica was exposed to various fermentations: no fermentation (0 min), partial fermentation (120 min) and full fermentation (24 h). Total phenolic content (TPC) and ferric-reducing antioxidant power (FRAP) of C. asiatica, found that C. asiatica herbal teas should be prepared at 100 °C for 10 min to obtain the optimum antioxidant capacity. Multiple brewing steps in C. asiatica herbal tea are encouraged due to the certain amount of antioxidant obtained, according to "Antioxidant capacity and phenolic composition of fermented Centella asiatica herbal teas" by Ariffin F, Heong Chew S, Bhupinder K, Karim AA, Huda N.(80)

d. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(78) http://www.ncbi.nlm.nih.gov/pubmed/22112723
(79) http://www.ncbi.nlm.nih.gov/pubmed/22074576
(80) http://www.ncbi.nlm.nih.gov/pubmed/21987075

Dietary Minerals Calcium: Neuronal calcium homeostasis in the aging nervous system

Dietary Minerals

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

Calcium

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Neuronal calcium homeostasis in the aging nervous system

Numerous studies indicate various disturbances of the Ca2+ homeostasis on different levels like Ca2+ channel properties, 45Ca2+ uptake, or Ca2+ binding proteins. Investigations on alterations of the free intracellular calciumconcentration ([Ca2+]i) in presynaptic synaptosomal preparations led to inconsistent results reporting increased or unchanged [Ca2+]i in aged animals, according to the Central Institute of Mental Health, Dept. Psychopharmacology(11).

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(11) http://www.ncbi.nlm.nih.gov/pubmed/7997060

Medical Advisor Journals

Pages

Natural Medicine for Fatty Liver And Obesity Reversal

Tuesday, August 30, 2016

Herbal therapy: Popular Herbal St John's wort (Hypericum perforatum)

Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Lu Tou (Semen Phaseoli radiati)

General Health: Cirrhosis - Treatments in Conventional Medicine - Cirrhosis Surgery

Overcome Infertility: Hormone Evaluation of Male Infertility In Conventional medicine Perspective

Most Common Diseases of Ages of 50 Plus: Cancers - The Classification of Cancer

Children Health: Attention Deficit Disorder (ADHD/ADD) -Treatments In Herbal medicine perspective - Gotu Kola

Dietary Minerals Calcium: Neuronal calcium homeostasis in the aging nervous system