Neuro-toxicity is a condition of brain damage caused by exposure to toxic substances.
The toxic condition was found to reduce the brain function in transmitting and processing signals to other parts of the nervous system.
Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.
Depending on the area and location of neurons damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.
According to the statistics provided by the University of Ibadan, in the United States, for instance, out of 63 million youths under 18 years of age, about 10% have diagnosable neurobehavioural problems with only 20% receiving therapy and the magnitude affected by neurotoxicity is unknown.
The University continued, "The adverse effects of neurotoxicity are among the most feared ill health in humans because they adversely affect the quality of life", and "Undoubtedly, the magnitude and potential severity of neurotoxicity problems make it imperative to invest in resources required to strengthen the basis for preventive intervention, the forerunner of which is the development of biomarkers for neurotoxicity at the individual and population levels".
In other words, out of millions of people who have neurobehavioural problems, researchers do not know how many of them are actually caused by toxicity.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the analysis of natural compound with neuroprotective effect in patients with diabetes, researchers examined the antioxidants richly present in bilberry fruits effects on diabetes-related brain dysfunctions.
The study included the differentiation of the expression patterns of αCaMKII in hippocampal neurons from non-diabetic, diabetic and diabetic rats fed with an extract of bilberry fruit.
Where Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) plays a significant role in cognitive processes.
Diabetic rats hippocampal neurons immunoreactive (ir) to αCaMKII were swollen and the lengths of the neuronal fibers were reduced compared to the significantly longer of αCaMKII-positive nerve fibers in diabetic rats fed with bilberry fruit.
Injection of bilberry fruit also induced significant changes in the average larger diameter of αCaMKII-ir hippocampal neurons.
The results suggested that bilberry fruits exerted the neuroprotective effect on hippocampal neurons in diabetes through its antioxidants activity.
Furthermore, in order to find more information of bilberry effect on the brain, researchers examined it's anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) neuroprotective effect against retinal damage in vitro and in vivo.
In RGC cultures, VMA and all three anthocyanidins protected the brain against SIN-1 (chloride) toxicity, inhibited lipid peroxidation in mouse forebrain homogenates through the antioxidant property and NMDA-induced morphological retinal damage by allowing high levels of calcium ions (Ca2+) to enter the cells.
Moreover, VMA and all three anthocyanidins also protected the retinal damage by increasing the TUNEL-positive cells in the ganglion cell layer.
Dr. Matsunaga N, the lead scientists said, "VMA and its anthocyanidins have neuroprotective effects (exerted at least in part via an anti-oxidation mechanism) in these in vitro and in vivo models of retinal diseases".
Taken altogether, bilberry may be considered a functional food for prevention and treatment of neurological diseases associated with neurotoxicity, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinalneuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H.(PubMed)
(3) Environmental Chemicals and Human Neurotoxicity: Magnitude, Prognosis and Markers by Anetor J. I. 1, Anetor G.O. 2, Iyanda AA1 , Adeniyi FAA. (the University of Ibadan)
Sunday, May 19, 2019
Whole Food Ginger, the Best for the Treatment of Gastroesophageal Reflux Disease (GERD)
Gastroesophageal reflux disease (GERD) is a digestive disorder caused by the relaxation of the low end of the esophageal sphincter muscle which connects with the stomach at the wrong times, leading to return of the stomach's contents back up into the esophagus.
Under normal digestion, the lower esophageal sphincter (LES) closed after opening to allow food to pass into the stomach.
People with GERD may have symptoms of heartburn, a burning sensation in your chest usually after eating, chest pain, regurgitation of food or acid liquid.
In serious cases, patients may experience symptoms of difficulty swallowing.
Most cases of GERD symptoms can be managed by lifestyle changes and over-the-counter medications. However, some people may need surgery to ease symptoms.
Unmanaged GERD has been found to damage the esophageal tissue and dysfunctional valve at the top of the stomach and bottom of the esophagus in some patients.
The exact causes of GERD are unidentified. Being overweight and obesity, intake of certain medications, being a smoker and exposed to second-hand smoke are some factors associated with the prevalent risk of the condition.
Out of many risk factors, some researchers suggested aging may be a common risk of GERD in the elderly.
Dr. David A. Johnson, said, "The prevalence of erosive esophagitis and other complications of gastroesophageal reflux disease increase with age. Additionally, among all people with GERD, older adults are more likely to suffer severe complications, such as Barrett esophagus and esophageal carcinoma, than are younger people".
And, "Older age was associated independently with increasing acid exposure (P<0.0001), decreases in intra-abdominal LES length (P<0.001), increases in esophageal dysmotility, and increasingly ineffective peristalsis".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the urgency to find a natural compound for the treatment of gastroesophageal reflux disease (GERD) and bile reflux gastritis (BRG) which are common gastrointestinal (GI) disorders with unmet medical needs, researchers evaluated the ginger-containing formula Wendan decoction (WDD) targets homeostatic disturbances.
The Wendan decoction (WDD) has been used for thousands of year in traditional Chinese medicine for the treatment of syndromes characterized by "reflux" and "gut-juice exposure" problems.
After reviewing medical data online, 33 studies involved 3253 participants (1351 vs. 1035 of the BRG in 20 publications, 449 vs. 418 of the GERD in 13 studies, and 194 vs. 159 of relapse rate in 6 trials) was selected.
According to the pooled data, application of WDD showed a consistent therapeutic efficacy on BRG (OR = 6.00, 95%C = 4.68-7.69) and GERD (OR = 4.39, 95%CI = 2.72-7.07).
The relapse rate was 12.4% for WDD which significantly lower than 44.0% in the conventional therapies (OR = 0.14, 95%CI = 0.08-0.26).
After taking into account co and confounders, researchers wrote on the final report, "The consistent therapeutic efficacy of the single TCM formula on GERD and BRD indirectly indicates reflux as common pathogenesis in reflux-associated GI disorders".
Take all together, ginger used alone or combined with other herbal medicines may be considered the functional alternatives for the treatment of GERD and BRD, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders by Ling W1, Huang Y1,2, Xu JH1,3, Li Y1,4, Huang YM1, Ling HB1,5, Sui Y6, Zhao HL. (PubMed)
(2) GERD and Aging by David A. Johnson, MD reviewing Lee J et al. Clin Gastroenterol Hepatol 2007 Dec. (NEJM Journal Watch)
Under normal digestion, the lower esophageal sphincter (LES) closed after opening to allow food to pass into the stomach.
People with GERD may have symptoms of heartburn, a burning sensation in your chest usually after eating, chest pain, regurgitation of food or acid liquid.
In serious cases, patients may experience symptoms of difficulty swallowing.
Most cases of GERD symptoms can be managed by lifestyle changes and over-the-counter medications. However, some people may need surgery to ease symptoms.
Unmanaged GERD has been found to damage the esophageal tissue and dysfunctional valve at the top of the stomach and bottom of the esophagus in some patients.
The exact causes of GERD are unidentified. Being overweight and obesity, intake of certain medications, being a smoker and exposed to second-hand smoke are some factors associated with the prevalent risk of the condition.
Out of many risk factors, some researchers suggested aging may be a common risk of GERD in the elderly.
Dr. David A. Johnson, said, "The prevalence of erosive esophagitis and other complications of gastroesophageal reflux disease increase with age. Additionally, among all people with GERD, older adults are more likely to suffer severe complications, such as Barrett esophagus and esophageal carcinoma, than are younger people".
And, "Older age was associated independently with increasing acid exposure (P<0.0001), decreases in intra-abdominal LES length (P<0.001), increases in esophageal dysmotility, and increasingly ineffective peristalsis".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the urgency to find a natural compound for the treatment of gastroesophageal reflux disease (GERD) and bile reflux gastritis (BRG) which are common gastrointestinal (GI) disorders with unmet medical needs, researchers evaluated the ginger-containing formula Wendan decoction (WDD) targets homeostatic disturbances.
The Wendan decoction (WDD) has been used for thousands of year in traditional Chinese medicine for the treatment of syndromes characterized by "reflux" and "gut-juice exposure" problems.
After reviewing medical data online, 33 studies involved 3253 participants (1351 vs. 1035 of the BRG in 20 publications, 449 vs. 418 of the GERD in 13 studies, and 194 vs. 159 of relapse rate in 6 trials) was selected.
According to the pooled data, application of WDD showed a consistent therapeutic efficacy on BRG (OR = 6.00, 95%C = 4.68-7.69) and GERD (OR = 4.39, 95%CI = 2.72-7.07).
The relapse rate was 12.4% for WDD which significantly lower than 44.0% in the conventional therapies (OR = 0.14, 95%CI = 0.08-0.26).
After taking into account co and confounders, researchers wrote on the final report, "The consistent therapeutic efficacy of the single TCM formula on GERD and BRD indirectly indicates reflux as common pathogenesis in reflux-associated GI disorders".
Take all together, ginger used alone or combined with other herbal medicines may be considered the functional alternatives for the treatment of GERD and BRD, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders by Ling W1, Huang Y1,2, Xu JH1,3, Li Y1,4, Huang YM1, Ling HB1,5, Sui Y6, Zhao HL. (PubMed)
(2) GERD and Aging by David A. Johnson, MD reviewing Lee J et al. Clin Gastroenterol Hepatol 2007 Dec. (NEJM Journal Watch)
Friday, May 17, 2019
Tomato Protects Diabetics Against Complications Caused by Oxidative Stress
Oxidative stress is an imbalanced ratio of free radicals and antioxidant enzymes produced by the host.
In other words, diseases associated with oxidative stress such as cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer are results of the prolonged period overexpression free radicals compared to reduced levels of antioxidants.
Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order to become stable, free radicals readily steal or donate an electron from other molecules, leading to a free radical cascade that cannot be stopped until all outer ring electrons are paired or inhibited by antioxidants.
Antioxidants are stable molecules that inhibit oxidation.
Diabetes is a chronic condition of insufficient insulin entered the bloodstream, caused either by the gradual died-off of the beta cells in the pancreas or insulin receptors clogged-up by cholesterol.
In our body, free radicals induced by cell metabolism for the body to function normally are inhibited by the antixodants either produced by the body or intake of antioxidant chemical compounds from the dietary sources.
Free radicals can enter our body from environmental factors, such as the air we breathe, the foods we eat.
Some researchers suggested that the reduced levels of antioxidants against the overexpression of free radicals are most likely occurred to people with a weakened immunes system such as the elderly due to aging.
Dr. Viviana I Pérez, the lead scientist said, "Currently, the Oxidative Stress (or Free Radical) Theory of Aging is the most popular explanation of how aging occurs at the molecular level".
And, "While data from studies in invertebrates (e.g., C. elegans and Drosophila) and rodents show a correlation between increased lifespan and resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules), direct evidence showing that alterations in oxidative damage/stress play a role in aging".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a natural compound for the treatment of diabetes with no side effect, researchers examined the beneficial effect of tomatoes in diabetics.
Participants with type-II diabetic group (n=40) and age-matched control group (n=50 are included in the study.
Before treatment, the type-II diabetic group showed significantly lower levels of antioxidant enzymes and very high lipid peroxidation rate compared to the control group.
According to the analysis of the short term supplementation, tomatoes (cooked) showed a significant improvement in antioxidant enzyme levels and decreased lipid peroxidation rate in the diabetic group for a period of 30 days.
Once again, in the total of 90 subjects included type 2 diabetic group (n = 40) and an age-matched control group (n = 50), researchers once against investigated the anti-diabetes activity of lycopene.
Patients with type 2 diabetes significantly lower levels of antioxidant enzymes and very high lipid peroxidation, as well as higher levels of lipid profile and glycated hemoglobin (HbA1c), compared to controls before application of lycopene.
Long term tomato supplementation in diabetes mellitus showed a significant improvement in the levels of antioxidant enzymes and decreased lipid peroxidation rate (p < 0.001), with no effect on lipid profile and glycated hemoglobin HbA1c levels.
In other words, long term tomato injection protects diabetics against complication associated with abnormally high levels of high blood glucose and lipid, through its antioxidant activity.
Taken altogether, tomatoes may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of short term supplementation of tomatoes on antioxidant enzymes and lipid peroxidation in type-II diabetes by Subhash K1, Bose C, Agrawal BK. (PubMed)
(2) Effect of long term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile and glycated hemoglobin in Type 2 diabetes mellitus by Bose KS1, Agrawal BK. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)
In other words, diseases associated with oxidative stress such as cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer are results of the prolonged period overexpression free radicals compared to reduced levels of antioxidants.
Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order to become stable, free radicals readily steal or donate an electron from other molecules, leading to a free radical cascade that cannot be stopped until all outer ring electrons are paired or inhibited by antioxidants.
Antioxidants are stable molecules that inhibit oxidation.
Diabetes is a chronic condition of insufficient insulin entered the bloodstream, caused either by the gradual died-off of the beta cells in the pancreas or insulin receptors clogged-up by cholesterol.
In our body, free radicals induced by cell metabolism for the body to function normally are inhibited by the antixodants either produced by the body or intake of antioxidant chemical compounds from the dietary sources.
Free radicals can enter our body from environmental factors, such as the air we breathe, the foods we eat.
Some researchers suggested that the reduced levels of antioxidants against the overexpression of free radicals are most likely occurred to people with a weakened immunes system such as the elderly due to aging.
Dr. Viviana I Pérez, the lead scientist said, "Currently, the Oxidative Stress (or Free Radical) Theory of Aging is the most popular explanation of how aging occurs at the molecular level".
And, "While data from studies in invertebrates (e.g., C. elegans and Drosophila) and rodents show a correlation between increased lifespan and resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules), direct evidence showing that alterations in oxidative damage/stress play a role in aging".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a natural compound for the treatment of diabetes with no side effect, researchers examined the beneficial effect of tomatoes in diabetics.
Participants with type-II diabetic group (n=40) and age-matched control group (n=50 are included in the study.
Before treatment, the type-II diabetic group showed significantly lower levels of antioxidant enzymes and very high lipid peroxidation rate compared to the control group.
According to the analysis of the short term supplementation, tomatoes (cooked) showed a significant improvement in antioxidant enzyme levels and decreased lipid peroxidation rate in the diabetic group for a period of 30 days.
Once again, in the total of 90 subjects included type 2 diabetic group (n = 40) and an age-matched control group (n = 50), researchers once against investigated the anti-diabetes activity of lycopene.
Patients with type 2 diabetes significantly lower levels of antioxidant enzymes and very high lipid peroxidation, as well as higher levels of lipid profile and glycated hemoglobin (HbA1c), compared to controls before application of lycopene.
Long term tomato supplementation in diabetes mellitus showed a significant improvement in the levels of antioxidant enzymes and decreased lipid peroxidation rate (p < 0.001), with no effect on lipid profile and glycated hemoglobin HbA1c levels.
In other words, long term tomato injection protects diabetics against complication associated with abnormally high levels of high blood glucose and lipid, through its antioxidant activity.
Taken altogether, tomatoes may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of short term supplementation of tomatoes on antioxidant enzymes and lipid peroxidation in type-II diabetes by Subhash K1, Bose C, Agrawal BK. (PubMed)
(2) Effect of long term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile and glycated hemoglobin in Type 2 diabetes mellitus by Bose KS1, Agrawal BK. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)
3,3'-Diindolylmethane Protects the Heart Muscle Against the Onset of Cardiovascular Disease (CVD)
Heart muscle or myocardium is one of three types of muscles in human, that build the walls of the heart.
Most common diseases of heart muscle include angina pectoris and myocardial infarction, and other heart muscle disease caused by restricting blood supply to the muscle.
Most common symptoms of heart muscle diseases include tightness, pain, or swelling of the legs, ankles, and feet
Some patients may also experience symptoms of gastrointestinal discomforts include bloating, abdominal pain and shortness of breath caused by the reduced blood supply.
Most common risk factors associated with heart muscle disease including high blood pressure, heart tissue damage, heart problems, metabolic syndrome, nutritional deficiencies, excessive alcohol drinking.
Some researchers suggested that genetic preposition may have a strong effect in the induction of heart muscle disease.
The Genetics Home Reference wrote, " mutations in more than 30 genes have been found to cause familial dilated cardiomyopathy. These genes provide instructions for making proteins that are found in cardiac muscle cells called cardiomyocytes.
And, "Mutations in one gene, TTN, account for approximately 20 percent of cases of familial dilated cardiomyopathy".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
On finding a natural ingredient which protects the heart muscle against the onset of cardiovascular disease researchers examined the 3, 3'-Diindolylmethane (DIM) effects on cardiomyocytes.
Tested cell lines H9C2 used in the study was evaluated by DIM's influence on inflammation and apoptosis of cardiomyocytes induced by LPS. H9C2 cells incubated with DIM (10, 20 and 30 μM) with or without LPS for 24 h.
Treatment with various concentrations of DIM (10, 20 and 30 μM) inhibited the overabundance of pro-inflammatory cytokines (TNF-α and IL-6 mRNA expression) induced by LPS.
In other words, DIM normalized the levels of impaired TNF-α and IL-6 mRNA expression, in the LPS + DIM30(μM) group.
According to the tested assays, DIM treatment significantly blocked LPS-induced oxidative stress and inhibited LPS-induced apoptosis in H9C2 cardiomyocytes.
Furthermore, DIM significantly inhibited the LPS-induced expression of a protein associated with proapoptosis and enhanced the expression of a protein involved anti-apoptosis.
Dr. Luo Q, the lead scientist, wrote on the final report, "DIM may have a protective effect for H9C2 cardiomyocytes against LPS-induced inflammatory response and apoptosis. DIM may be a new insight into the treatment of septic cardiomyopathy".
In order to find out more information about DIM anti-cardiovascular disease activity, researchers evaluated the function of DIM on the hypoxia‑induced cardiac injury.
The study included H9c2 cells pretreated with DIM (1, 5 and 10 µM) for 12 h and exposed to hypoxia for 12 h.
DIM with different doses extended markedly attenuated the increased transcription of pro-inflammatory cytokines (interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α) induced by hypoxia.
DIM modulated the genes associated with transcription of autophagy, compared with the hypoxia group.
DIM also protected the cells against apoptosis through inhibiting and exhibiting the proteins associated with anti-apoptosis and pro-apoptosis, respectively.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the protection of heart muscle against the risk of heart disease, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosis by Luo Q1,2,3, Yang A1,2,3, Cao Q1,2,3, Guan H. (PubMed)
(2) 3,3'‑Diindolylmethane attenuates cardiomyocyte hypoxia by modulating autophagy in H9c2 cells by Liang K1, Qian WH1, Zong J. (PubMed)
(3) Familial dilated cardiomyopathy by The Genetics Home Reference. (NIH)
Most common diseases of heart muscle include angina pectoris and myocardial infarction, and other heart muscle disease caused by restricting blood supply to the muscle.
Most common symptoms of heart muscle diseases include tightness, pain, or swelling of the legs, ankles, and feet
Some patients may also experience symptoms of gastrointestinal discomforts include bloating, abdominal pain and shortness of breath caused by the reduced blood supply.
Most common risk factors associated with heart muscle disease including high blood pressure, heart tissue damage, heart problems, metabolic syndrome, nutritional deficiencies, excessive alcohol drinking.
Some researchers suggested that genetic preposition may have a strong effect in the induction of heart muscle disease.
The Genetics Home Reference wrote, " mutations in more than 30 genes have been found to cause familial dilated cardiomyopathy. These genes provide instructions for making proteins that are found in cardiac muscle cells called cardiomyocytes.
And, "Mutations in one gene, TTN, account for approximately 20 percent of cases of familial dilated cardiomyopathy".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
On finding a natural ingredient which protects the heart muscle against the onset of cardiovascular disease researchers examined the 3, 3'-Diindolylmethane (DIM) effects on cardiomyocytes.
Tested cell lines H9C2 used in the study was evaluated by DIM's influence on inflammation and apoptosis of cardiomyocytes induced by LPS. H9C2 cells incubated with DIM (10, 20 and 30 μM) with or without LPS for 24 h.
Treatment with various concentrations of DIM (10, 20 and 30 μM) inhibited the overabundance of pro-inflammatory cytokines (TNF-α and IL-6 mRNA expression) induced by LPS.
In other words, DIM normalized the levels of impaired TNF-α and IL-6 mRNA expression, in the LPS + DIM30(μM) group.
According to the tested assays, DIM treatment significantly blocked LPS-induced oxidative stress and inhibited LPS-induced apoptosis in H9C2 cardiomyocytes.
Furthermore, DIM significantly inhibited the LPS-induced expression of a protein associated with proapoptosis and enhanced the expression of a protein involved anti-apoptosis.
Dr. Luo Q, the lead scientist, wrote on the final report, "DIM may have a protective effect for H9C2 cardiomyocytes against LPS-induced inflammatory response and apoptosis. DIM may be a new insight into the treatment of septic cardiomyopathy".
In order to find out more information about DIM anti-cardiovascular disease activity, researchers evaluated the function of DIM on the hypoxia‑induced cardiac injury.
The study included H9c2 cells pretreated with DIM (1, 5 and 10 µM) for 12 h and exposed to hypoxia for 12 h.
DIM with different doses extended markedly attenuated the increased transcription of pro-inflammatory cytokines (interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α) induced by hypoxia.
DIM modulated the genes associated with transcription of autophagy, compared with the hypoxia group.
DIM also protected the cells against apoptosis through inhibiting and exhibiting the proteins associated with anti-apoptosis and pro-apoptosis, respectively.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the protection of heart muscle against the risk of heart disease, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosis by Luo Q1,2,3, Yang A1,2,3, Cao Q1,2,3, Guan H. (PubMed)
(2) 3,3'‑Diindolylmethane attenuates cardiomyocyte hypoxia by modulating autophagy in H9c2 cells by Liang K1, Qian WH1, Zong J. (PubMed)
(3) Familial dilated cardiomyopathy by The Genetics Home Reference. (NIH)
Thursday, May 16, 2019
Bioactive Cucurbitacin B (CuB) Isolated from Cucumber Harbors Potent Chemopreventive Activity Against Prostate Cancer in Vitro and Vivo
Prostate cancer found mostly in the older men is a chronic condition characterized by irregular cell growth in the prostate tissues caused by the alternation of cell DNA.
Most cases of prostate cancer start in the cells on the surface of the inner lining tissue before penetrating into deeper layers to induce a malignant tumor.
Believe it or not, prostate cancer can be classified into many different types, depending on the type of cell that causes the onset of primary cancer.
* Adenocarcinomas, the most common type of prostate cancer that develops in the gland cells that line the prostate gland.
* Ductal adenocarcinoma, the type of cancer starts in the cells that line the ducts (tubes) of the prostate gland. r
* Transitional cell cancer is cancer that starts in the cells that line the tube carrying urine to the outside of the body (the urethra).
* Squamous cell cancer is found to develop from flat cells that cover the prostate.
* Small cell prostate cancer is found in tissue made up of small round cells.
Prostate cancer can also be classified into different stages
1. Stage 0
If the cancerous cell has not penetrated in deeper tissue but in the surface of the prostate lining.
2. Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded into deep the prostate lining, but still completely inside the prostate.
a. Stage IA1
The cancer is not ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
a.1. Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
a.2. Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
b. Stage IB:
Cancer in this stage has invaded the connective tissue, & less than 5cm (2 inches).
b.1. Stage IB1: Cancer is 4 cm large (1 3/4 inches).b.2. Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (2 inches)
3. Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the prostate.
4. Stage III
In this stage, cancerous cells have spread to the tissues immediately surrounding the prostate.
5. Stage IV
In this stage, cancerous cells have spread to the tissues immediately outside of the prostate, into other distant parts of the body
Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural and potential ingredient for the treatment of prostate cancer with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables.
In PC-3 and LNCaP prostate cancer cell lines, CuB significantly and specifically inhibited prostate cancer cell growth with low IC50 at a concentration of 0.3 μM.
CuB induced cancer cell apoptosis by modulating the proteins associated with program cell death and pro-apoptotic pathways.
Furthermore, the bioactive compound also increased the accumulation of Sub-G0/G1 population before exhibiting cell cycle arrest.
According to the results of a chemopreventive model, pre-treatment of mice with CuB(2 weeks before PC-3 prostate cancer cell implantation significantly reduced the rate in vivo tumor-formation.
Moreover, CuB resulted in a 79% reduction in tumor size (accompanied by marked in situ apoptosis) of the treated group without causing noticeable toxicity compared to controls at day 31.
In vitro and in the CuB-chemopreventive mouse model, CuB at a dose-dependent inhibited enzyme ATP citrate lyase phosphorylation associated with cancer cell metabolism.
The findings suggested that CuB harbors potent chemopreventive activity against prostate cancer via a number of mechanisms, without inducing harmful side effects.
Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth by Gao Y1, Islam MS1, Tian J1, Lui VW2, Xiao D. (PubMed)
Most cases of prostate cancer start in the cells on the surface of the inner lining tissue before penetrating into deeper layers to induce a malignant tumor.
Believe it or not, prostate cancer can be classified into many different types, depending on the type of cell that causes the onset of primary cancer.
* Adenocarcinomas, the most common type of prostate cancer that develops in the gland cells that line the prostate gland.
* Ductal adenocarcinoma, the type of cancer starts in the cells that line the ducts (tubes) of the prostate gland. r
* Transitional cell cancer is cancer that starts in the cells that line the tube carrying urine to the outside of the body (the urethra).
* Squamous cell cancer is found to develop from flat cells that cover the prostate.
* Small cell prostate cancer is found in tissue made up of small round cells.
Prostate cancer can also be classified into different stages
1. Stage 0
If the cancerous cell has not penetrated in deeper tissue but in the surface of the prostate lining.
2. Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded into deep the prostate lining, but still completely inside the prostate.
a. Stage IA1
The cancer is not ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
a.1. Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
a.2. Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
b. Stage IB:
Cancer in this stage has invaded the connective tissue, & less than 5cm (2 inches).
b.1. Stage IB1: Cancer is 4 cm large (1 3/4 inches).b.2. Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (2 inches)
3. Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the prostate.
4. Stage III
In this stage, cancerous cells have spread to the tissues immediately surrounding the prostate.
5. Stage IV
In this stage, cancerous cells have spread to the tissues immediately outside of the prostate, into other distant parts of the body
Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural and potential ingredient for the treatment of prostate cancer with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables.
In PC-3 and LNCaP prostate cancer cell lines, CuB significantly and specifically inhibited prostate cancer cell growth with low IC50 at a concentration of 0.3 μM.
CuB induced cancer cell apoptosis by modulating the proteins associated with program cell death and pro-apoptotic pathways.
Furthermore, the bioactive compound also increased the accumulation of Sub-G0/G1 population before exhibiting cell cycle arrest.
According to the results of a chemopreventive model, pre-treatment of mice with CuB(2 weeks before PC-3 prostate cancer cell implantation significantly reduced the rate in vivo tumor-formation.
Moreover, CuB resulted in a 79% reduction in tumor size (accompanied by marked in situ apoptosis) of the treated group without causing noticeable toxicity compared to controls at day 31.
In vitro and in the CuB-chemopreventive mouse model, CuB at a dose-dependent inhibited enzyme ATP citrate lyase phosphorylation associated with cancer cell metabolism.
The findings suggested that CuB harbors potent chemopreventive activity against prostate cancer via a number of mechanisms, without inducing harmful side effects.
Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth by Gao Y1, Islam MS1, Tian J1, Lui VW2, Xiao D. (PubMed)
Bilberry Processed Anti Alzheimer's disease Potency in Vitro and Vivo
Alzheimer's disease is a chronic neurodegenerative disease caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.
The disease is most prevalent in the elderly and causes over 60% of all cases of dementia.
According to the statistics, approximately 5.7 million Americans of all ages have Alzheimer's. 15.9 million family caregivers provided an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Epidemiological studies suggested that Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time.
Although, less 10% of patients with AD are associated with a genetic preposition. Patients with such a mutated gene are virtually guaranteed to develop the disease.
More precisely, any one of a number of different single-gene mutations on chromosomes 21, 14, and 1 was found to induce the onset of AD.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of Alzheimer's disease (AD) investigated the effects of anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the in vitro progression of Aβ fibril formation and in vivo effects of this compound on AD pathogenesis.
In Neuro2a cells, injection of VMA inhibited the in vitro formation of Aβ peptide fibrils in the induction of neurons toxicity.
Furthermore, A diet containing 1% VMA prevented the cognitive degeneration was found in the tested AD mice.
Interestingly, this diet in the retention of cognitive ability was not accompanied by a reduction in the aggregate deposition in brains but rather, an increase in insoluble deposits, compared to control mice.
The results suggested that VMA shows a strong effect on Alzheimer's disease by altering the Aβ aggregation to a non-toxic form.
In order to reveal more information about bilberry anti AD activity, researchers elucidated the effects of different polyphenols on neuroprotection and APP processing under different in vitro stress conditions.
Injection of myricetin, quercetin or anthocyanin-rich extracts in a dose-dependent manner significantly inhibited the overexpression of free radicals caused by the application of Menadione.
APdE9 mice fed with anthocyanin-rich bilberry or blackcurrant extracts showed decreased APP C-terminal fragment levels, the amyloid precursor protein in the cerebral cortex, compared to APdE9 mice on the control diet.
Levels of soluble Aβ40 and Aβ42 levels were found to significantly decrease in bilberry-fed mice, compared to blackcurrant-fed mice.
Additionally, bilberry diet also improved the spatial working memory of aged APdE9 mice, compared to mice on the control diet.
Based on the findings, Dr. Vepsäläinen S, the lead scientist wrote in the final report, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
Taken altogether, bilberry rich of anthocyanin may be considered a functional remedy for the prevention and treatment of Alzheimer's disease (AD), pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata Y. (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
The disease is most prevalent in the elderly and causes over 60% of all cases of dementia.
According to the statistics, approximately 5.7 million Americans of all ages have Alzheimer's. 15.9 million family caregivers provided an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Epidemiological studies suggested that Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time.
Although, less 10% of patients with AD are associated with a genetic preposition. Patients with such a mutated gene are virtually guaranteed to develop the disease.
More precisely, any one of a number of different single-gene mutations on chromosomes 21, 14, and 1 was found to induce the onset of AD.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of Alzheimer's disease (AD) investigated the effects of anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the in vitro progression of Aβ fibril formation and in vivo effects of this compound on AD pathogenesis.
In Neuro2a cells, injection of VMA inhibited the in vitro formation of Aβ peptide fibrils in the induction of neurons toxicity.
Furthermore, A diet containing 1% VMA prevented the cognitive degeneration was found in the tested AD mice.
Interestingly, this diet in the retention of cognitive ability was not accompanied by a reduction in the aggregate deposition in brains but rather, an increase in insoluble deposits, compared to control mice.
The results suggested that VMA shows a strong effect on Alzheimer's disease by altering the Aβ aggregation to a non-toxic form.
In order to reveal more information about bilberry anti AD activity, researchers elucidated the effects of different polyphenols on neuroprotection and APP processing under different in vitro stress conditions.
Injection of myricetin, quercetin or anthocyanin-rich extracts in a dose-dependent manner significantly inhibited the overexpression of free radicals caused by the application of Menadione.
APdE9 mice fed with anthocyanin-rich bilberry or blackcurrant extracts showed decreased APP C-terminal fragment levels, the amyloid precursor protein in the cerebral cortex, compared to APdE9 mice on the control diet.
Levels of soluble Aβ40 and Aβ42 levels were found to significantly decrease in bilberry-fed mice, compared to blackcurrant-fed mice.
Additionally, bilberry diet also improved the spatial working memory of aged APdE9 mice, compared to mice on the control diet.
Based on the findings, Dr. Vepsäläinen S, the lead scientist wrote in the final report, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
Taken altogether, bilberry rich of anthocyanin may be considered a functional remedy for the prevention and treatment of Alzheimer's disease (AD), pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata Y. (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
Wednesday, May 15, 2019
Herbal Bilberry, A Natural Prevention and Treatment of Alzheimer's disease (AD) with No Side Effects
Alzheimer's disease (AD) is a neurodegenerative disease found mostly in the aging population characterized impaired memory, thinking, and behavior. caused by the gradual loss or death of neurons. These symptoms are slowly getting worse over time and becoming severe enough to interfere with daily activity.
60 percent to 80 percent of dementia found in the US are involved in Alzheimer's disease (AD).
According to the statistics, the numbers of patients living with AD is growing fast, affecting over 5.5 million people age 65 and older. AD is a sith leading cause of death in the US. Most patients AD lives four to eight years after diagnosis. However, the years of survival rate is totally depending on other factors.
Contrast to general belief, getting old is a risk factor of AD but AD is not a disease of aging. Approximately 200,000 Americans under the age of 65 have younger-onset Alzheimer’s disease.
As of today, there is no cure for AD, the aim of treatment is to slow down the severity of the symptoms and delay the progression of the disease.
In other words, treatment is to improve the quality of life for both patients and their caregivers.
Besides aging, physically active, smoking, excessive alcohol drinking, medical conditions such as metabolic syndrome, stress are some of the prevalent risks of AD.
Some researchers in the investigation of the correlation between obesity and AD wrote, "There is ample scientific as well as empirical evidence that obesity and its metabolic and vascular comorbidities are related to AD and likely in the causative pathway".
And, "Obesity prevention and treatment could prove to be an efficacious and safe approach to preventing AD, a serious and daunting epidemic disease".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the searching a natural ingredient for the treatment of Alzheimer's disease with no side effects, researchers at the effects of different polyphenols on neuroprotection and APP processing under different stress conditions in transgenic AD mice (APdE9).
Selected mice induced free radical toxicity and apoptosis in human SH-SY5Y neuroblastoma cells overexpressing APP751.
APdE9 mice fed with anthocyanin-rich bilberry showed the decreased Amyloid Precursor Protein (APP)APP C-terminal fragment levels, the indication of reduced death of neurons in the cerebral cortex compared to APdE9 mice fed with control diet.
Furthermore, soluble Aβ40 and Aβ42 levels, the plaque in the brain associated with increased risk for AD, mild cognitive impairment, and cognitive decline were significantly decreased in bilberry-fed mice, compared to blackcurrant-fed mice.
Moreover, bilberry diet protected the spatial working memory of aged APdE9 mice, compared to mice on the control diet, thus reducing the risk of deficits.
The results clearly suggested bilberry diet protects the integrity and viability of the neuron in the brain against the risk of AD.
Dr. Vepsäläinen S, the lead scientist said, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
In order to reveal more information of bilberry anti AD activity, researchers examined the anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the aggregation and deposition of the amyloid beta (Aβ1-42) peptide in fibrillar form.
According to the tested assays, injection of VMA protected Neuro2a cells by inhibiting the formation of Aβ peptide fibrils and reducing the toxicity of these aggregates in vitro.
A diet containing 1% VMA was found to exhibit the significant activity in the prevention of the cognitive degeneration in AD tested mice.
Interestingly, VMA promoted the cognitive ability accompanied not by a reduction in an aggregate deposition in brains, rather an increase in insoluble deposits compared to control diet mice.
In other words, bilberry protected the brain neuro against the risk AD by diverting Aβ aggregation to insoluble deposits, an alternate, non-toxic form.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a function remedy for the prevention and treatment of AD, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata, (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
(3) Obesity as a risk factor for Alzheimer's disease: weighing the evidence by Alford S1, Patel D2,3, Perakakis N4, Mantzoros CS. (PubMed)
60 percent to 80 percent of dementia found in the US are involved in Alzheimer's disease (AD).
According to the statistics, the numbers of patients living with AD is growing fast, affecting over 5.5 million people age 65 and older. AD is a sith leading cause of death in the US. Most patients AD lives four to eight years after diagnosis. However, the years of survival rate is totally depending on other factors.
Contrast to general belief, getting old is a risk factor of AD but AD is not a disease of aging. Approximately 200,000 Americans under the age of 65 have younger-onset Alzheimer’s disease.
As of today, there is no cure for AD, the aim of treatment is to slow down the severity of the symptoms and delay the progression of the disease.
In other words, treatment is to improve the quality of life for both patients and their caregivers.
Besides aging, physically active, smoking, excessive alcohol drinking, medical conditions such as metabolic syndrome, stress are some of the prevalent risks of AD.
Some researchers in the investigation of the correlation between obesity and AD wrote, "There is ample scientific as well as empirical evidence that obesity and its metabolic and vascular comorbidities are related to AD and likely in the causative pathway".
And, "Obesity prevention and treatment could prove to be an efficacious and safe approach to preventing AD, a serious and daunting epidemic disease".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the searching a natural ingredient for the treatment of Alzheimer's disease with no side effects, researchers at the effects of different polyphenols on neuroprotection and APP processing under different stress conditions in transgenic AD mice (APdE9).
Selected mice induced free radical toxicity and apoptosis in human SH-SY5Y neuroblastoma cells overexpressing APP751.
APdE9 mice fed with anthocyanin-rich bilberry showed the decreased Amyloid Precursor Protein (APP)APP C-terminal fragment levels, the indication of reduced death of neurons in the cerebral cortex compared to APdE9 mice fed with control diet.
Furthermore, soluble Aβ40 and Aβ42 levels, the plaque in the brain associated with increased risk for AD, mild cognitive impairment, and cognitive decline were significantly decreased in bilberry-fed mice, compared to blackcurrant-fed mice.
Moreover, bilberry diet protected the spatial working memory of aged APdE9 mice, compared to mice on the control diet, thus reducing the risk of deficits.
The results clearly suggested bilberry diet protects the integrity and viability of the neuron in the brain against the risk of AD.
Dr. Vepsäläinen S, the lead scientist said, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
In order to reveal more information of bilberry anti AD activity, researchers examined the anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the aggregation and deposition of the amyloid beta (Aβ1-42) peptide in fibrillar form.
According to the tested assays, injection of VMA protected Neuro2a cells by inhibiting the formation of Aβ peptide fibrils and reducing the toxicity of these aggregates in vitro.
A diet containing 1% VMA was found to exhibit the significant activity in the prevention of the cognitive degeneration in AD tested mice.
Interestingly, VMA promoted the cognitive ability accompanied not by a reduction in an aggregate deposition in brains, rather an increase in insoluble deposits compared to control diet mice.
In other words, bilberry protected the brain neuro against the risk AD by diverting Aβ aggregation to insoluble deposits, an alternate, non-toxic form.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a function remedy for the prevention and treatment of AD, pending to the validation of larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata, (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
(3) Obesity as a risk factor for Alzheimer's disease: weighing the evidence by Alford S1, Patel D2,3, Perakakis N4, Mantzoros CS. (PubMed)
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