Wednesday, July 22, 2020
Herbal Dandelion(Taraxacum officinale) Processes Antiproliferative Activity Against Cancer
Cell proliferation is a radical growth of cells to replace the damage or injury through the cell cycle division.
Cell proliferation is a process and a necessary step for wound healing.
All normal cells undergo cell cycle division to replace the old cells with new cells through a limited cell division.
On the other hand, cancer cells can multiply definitely.
In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.
In the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.
A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.
In the programmed cell death gene, such as BCL-2 induce cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.
In the phytochemicals perspective, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.
Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists compare five different common South European species of Taraxacum (T. obovatum (Willd.) DC., T. marginellum H. Lindb., T. hispanicum H. Lindb., T. lambinonii Soest and T. lacistrum Sahlin) antioxidant and anti-proliferative activity.
According to the dissimilarities between species in LC/MS patterns, T. marginellum demonstrated a strong intracellular antioxidant activity and the cytotoxicity by reducing the expression of ROS.
Compared to the other 3 species, T. marginellum showed the most efficient against the induction of free radicals overexpression in vitro.
Furthermore, in free radical theory, compared to T. marginellum, T. obovatum was the best free radical scavenger and a relevant cytotoxic effect was found in T. lacistrum extract over HeLa and HepG2 cell lines.
Taken altogether, Dandelion may be considered an antioxidant remedy that processes antioxidant and anti-proliferative activity, in a type-dependent manner, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity by Mingarro DM1, Plaza A, Galán A, Vicente JA, Martínez MP, Acero N. (PubMed)
Tuesday, July 21, 2020
Herbal Turmeric Blocks the Onset of Oral Mucositis Caused By the Bacterial Infection
Oral mucositis is considered a side effect in patients who undergo cancer treatment, particularly chemotherapy and radiation.
In cancer, oral mucositis is caused by the reduced function of the immune system to protect the infection of open sores in the mucosa.
However, poor oral or dental health, smoking or chewing tobacco and drinking alcohol, female gender, dehydration, and patients who had previously cancer treatment, have kidney disease are some of the most common risk factors that cause the onset of oral mucositis.
The most common symptoms of oral mucositis are red, shiny, or swollen mouth and gums, sores in the mouth or on the gums or tongue, pain in the mouth or throat, mild burning, or pain when eating food.
Some patients may also experience symptoms of difficulty swallowing or talking, soft, whitish patches or pus in the mouth or on the tongue, particularly the increase of mucus or thicker saliva in the mouth.
Some researchers suggested the onset of oral mucositis in most cases are associated with people with a weakened immune system, including the use of chemotherapy.
Dr. Francesco Chiappelli wrote, "Mucositis is observed in a variety of immunosuppressed patients, but is most often consequential to cancer therapy. It appears as early as the third day of the intervention, and is usually established by Day 7 of treatment".
And, "The precise immune components involved in the etiology of mucositis are unclear, but evidence-based research (EBR) data has shown that applications of granulocyte–macrophage-colony stimulating factor prevent the onset of the exacerbation of oropharyngeal mucositis".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential compound for the treatment of oral mucositis(OM), researchers evaluated the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and/or radiotherapy by searching the database of Cochrane Library, LILACS, LIVIVO, PubMed, Scopus, and Web of Science.
After a two-step selection process, four randomized and one nonrandomized clinical trials were included in the analysis in which 2 studies suggested that topical application of turmeric/curcumin as a gel or mouthwash showed a reduced grade of mucositis, pain, erythema intensity, and ulcerative area.
In other words, the topical application of turmeric or curcumin may be effective in controlling signs and symptoms of oral mucositis in tested patients.
Furthermore, according to the study of 72 golden Syrian hamsters induced mucositis (OM) by 5-fluorouracil (5-FU) for 4 days randomly allocated into four groups: control, placebo, chamomilla, and a mucoadhesive formulation containing curcuminoid (MFC)
* On day 5, all groups exhibited OM
* On day 8, both MFC and chamomilla groups exhibited better-wound healing compared to other groups.
* Moreover, also on day 8, the MFC group demonstrated inhibited protein associated with stimulating new blood vessels for the OM to grow and proinflammatory cytokines to facilitate symptoms of OM, compared to placebo and control group.
Collectively, Dr. Schmidt TR, the lead scientist wrote in the final report, "these findings suggest that MFC has a therapeutic effect on OM, accelerating wound healing through re-epithelization and anti-inflammatory action as modulation of angiogenesis and TGF-β1 expression".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of OM, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of turmeric and curcumin on oral mucositis: A systematic review by Normando AGC1, de Menêses AG2, de Toledo IP1,3, Borges GÁ1, de Lima CL1, Dos Reis PED2, Guerra ENS. (PubMed).
(2) Mucoadhesive formulation containing Curcuma longa L. reduces oral mucositisinduced by 5-fluorouracil in hamsters by Schmidt TR1, Curra M1, Wagner VP1, Martins MAT1,2, de Oliveira AC3, Batista AC4, Valadares MC5, Marreto RN3, Martins MD. (PubMed)
(3) The Molecular Immunology of Mucositis: Implications for Evidence-Based Research in Alternative and Complementary Palliative Treatments by Francesco Chiappelli. (PMC)
In cancer, oral mucositis is caused by the reduced function of the immune system to protect the infection of open sores in the mucosa.
However, poor oral or dental health, smoking or chewing tobacco and drinking alcohol, female gender, dehydration, and patients who had previously cancer treatment, have kidney disease are some of the most common risk factors that cause the onset of oral mucositis.
The most common symptoms of oral mucositis are red, shiny, or swollen mouth and gums, sores in the mouth or on the gums or tongue, pain in the mouth or throat, mild burning, or pain when eating food.
Some patients may also experience symptoms of difficulty swallowing or talking, soft, whitish patches or pus in the mouth or on the tongue, particularly the increase of mucus or thicker saliva in the mouth.
Some researchers suggested the onset of oral mucositis in most cases are associated with people with a weakened immune system, including the use of chemotherapy.
Dr. Francesco Chiappelli wrote, "Mucositis is observed in a variety of immunosuppressed patients, but is most often consequential to cancer therapy. It appears as early as the third day of the intervention, and is usually established by Day 7 of treatment".
And, "The precise immune components involved in the etiology of mucositis are unclear, but evidence-based research (EBR) data has shown that applications of granulocyte–macrophage-colony stimulating factor prevent the onset of the exacerbation of oropharyngeal mucositis".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential compound for the treatment of oral mucositis(OM), researchers evaluated the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and/or radiotherapy by searching the database of Cochrane Library, LILACS, LIVIVO, PubMed, Scopus, and Web of Science.
After a two-step selection process, four randomized and one nonrandomized clinical trials were included in the analysis in which 2 studies suggested that topical application of turmeric/curcumin as a gel or mouthwash showed a reduced grade of mucositis, pain, erythema intensity, and ulcerative area.
In other words, the topical application of turmeric or curcumin may be effective in controlling signs and symptoms of oral mucositis in tested patients.
Furthermore, according to the study of 72 golden Syrian hamsters induced mucositis (OM) by 5-fluorouracil (5-FU) for 4 days randomly allocated into four groups: control, placebo, chamomilla, and a mucoadhesive formulation containing curcuminoid (MFC)
* On day 5, all groups exhibited OM
* On day 8, both MFC and chamomilla groups exhibited better-wound healing compared to other groups.
* Moreover, also on day 8, the MFC group demonstrated inhibited protein associated with stimulating new blood vessels for the OM to grow and proinflammatory cytokines to facilitate symptoms of OM, compared to placebo and control group.
Collectively, Dr. Schmidt TR, the lead scientist wrote in the final report, "these findings suggest that MFC has a therapeutic effect on OM, accelerating wound healing through re-epithelization and anti-inflammatory action as modulation of angiogenesis and TGF-β1 expression".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of OM, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of turmeric and curcumin on oral mucositis: A systematic review by Normando AGC1, de Menêses AG2, de Toledo IP1,3, Borges GÁ1, de Lima CL1, Dos Reis PED2, Guerra ENS. (PubMed).
(2) Mucoadhesive formulation containing Curcuma longa L. reduces oral mucositisinduced by 5-fluorouracil in hamsters by Schmidt TR1, Curra M1, Wagner VP1, Martins MAT1,2, de Oliveira AC3, Batista AC4, Valadares MC5, Marreto RN3, Martins MD. (PubMed)
(3) The Molecular Immunology of Mucositis: Implications for Evidence-Based Research in Alternative and Complementary Palliative Treatments by Francesco Chiappelli. (PMC)
Monday, July 20, 2020
Green Tea Polyphenols (GrTPs), the Anti Female Infertility Bioactive Ingredient, Scientists Find
Scientists may have found a beverage bioactive compound in improving the chance of fertility in female without inducing any side effects, some studies found,
Infertility is a condition characterized by the inability to get pregnant after 12 months of frequent and unprotected sex of a couple. Women who can carry the term of pregnancy are also considered as infertile.
According to the statistic, approximately 8 to 12 percent of couples worldwide experience fertility problems. Between 45 and 50 percent of cases of infertility are attributed to male reproductive problems.
The most common causes of infertility in the female in the US. are aging, medical condition of endometriosis, and polycystic ovarian syndrome (PCOS) which have a strong interruption of the female menstrual cycle, sexually transmitted infections (STIs) and obesity.
Other prevalent risk factors including physical and medical condition, such as blocked fallopian tubes due to pelvic inflammatory disease, and physical problems with the uterus and diabetes, long-term intakes of a certain medicine, such as anti-inflammatory drug and hormone imbalance that affect the menstrual cycle
Genetic preposition such as The HOXA13 gene. The only one single gene disorder has been shown to affect uterine development in infertile females.
Age, smoking, use of illicit drugs, excessive alcohol drinking, and long-term exposure to chemicals are the common causes of female infertility.
In term of diet, researchers at the Harvard T.H. Chan School of Public Health in the study "Diet and female fertility: doctor, what should I eat?" wrote, "According to existing data, women trying to achieve pregnancy are encouraged to increase consumption of whole grains, omega-3 fatty acids, fish, and soy and to reduce consumption of trans fats and red meat. In addition, a daily multivitamin that contains folic acid before and during pregnancy may not only prevent birth defects but also improve the chance of achieving and maintaining a pregnancy".
These results suggested that women who follow the diet with high in saturated and trans fat, intake of a large amount of red meat and processed food, and less in fruits, nuts, and vegetables are at a higher risk of infertility or of carrying the pregnancy to full term.
In the concerns of oxygen species (ROS), which are produced during cellular oxidation may reduce the chance of conception, researchers at the joint study led by the Uniwersytet Medyczny w Łodzi. launched an investigation to examine whether increased production of reactive oxygen species is an important factor in the etiopathogenesis of pregnancy and affects female reproduction.
Before the application of green tea s (GrTPs) researchers found that oxidative stress caused by overexpression of free radicals may damage the oocytes and may impair their fertilization capacity.
The increased ROS levels probably are the results of antioxidant enzymes produced by the tested subjects being suppressed due to some unknown mechanisms.
Oxidative stress may also lead to embryo fragmentation and formation of numerous developmental abnormalities and is regarded to be one of the important reasons for spontaneous and recurrent miscarriage
Oral administered green tea polyphenols (GrTPs) inhibits the overexpression of ROS showed to restore the embryo fragmentation and formation of numerous developmental abnormalities and increase the quality of female gametes, mostly via the capability of catechins to reduce ROS production.
Further analysis also suggested that GrTPs processed antioxidant properties that only restores the health of oocytes caused by overexpression of ROS but also improves age-related decline in female fertility rate, and gamete quality.
These unique properties of green tea catechins in improving the female reproductive health suggested green tea polyphenols (GrTPs) may be considered a functional food in protecting against the damage of the oocytes and their fertilization capacity and the integrity of embryo.
Dr, Rahman SU, the lead scientist at the final report, said, "the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals".
Additionally, in the concerns of the Reactive oxygen species (ROS) that may increase the risk of female infertility, researchers launched an investigation to examine whether green tea catechins protect the female gametes over the expression of ROS.
After taking into account levels of oxidative stress before and after application of green tea catechin, researchers wrote,
* Epigallocatechin-3-gallate (EGCG), a major bioactive compound in green tea inhibited the expression of ROS in facilitating the damage of female gametes through to its strong antioxidant activity.
* Green tea catechins potentially improves the oocyte maturation and may inhibit in-vitro maturation of the oocyte
Dr. Roychoudhury S, the lead author said, " (These results furtherly confirmed) the potential roles of green tea catechins on oxidative stress in male and female reproduction and fertility".
Taken altogether, Green tea polyphenols (GrTPs) may be considered an adjunct therapy in the protection of the female gametes and oocyte maturation against the onset of infertility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diet and female fertility: doctor, what should I eat? by Chiu YH1, Chavarro JE2, Souter I. (PubMed)
(2) Potential role of green tea catechins in the management of oxidative stress-associated infertility by Roychoudhury S1, Agarwal A2, Virk G3, Cho CL. (PubMed)
Infertility is a condition characterized by the inability to get pregnant after 12 months of frequent and unprotected sex of a couple. Women who can carry the term of pregnancy are also considered as infertile.
According to the statistic, approximately 8 to 12 percent of couples worldwide experience fertility problems. Between 45 and 50 percent of cases of infertility are attributed to male reproductive problems.
The most common causes of infertility in the female in the US. are aging, medical condition of endometriosis, and polycystic ovarian syndrome (PCOS) which have a strong interruption of the female menstrual cycle, sexually transmitted infections (STIs) and obesity.
Other prevalent risk factors including physical and medical condition, such as blocked fallopian tubes due to pelvic inflammatory disease, and physical problems with the uterus and diabetes, long-term intakes of a certain medicine, such as anti-inflammatory drug and hormone imbalance that affect the menstrual cycle
Genetic preposition such as The HOXA13 gene. The only one single gene disorder has been shown to affect uterine development in infertile females.
Age, smoking, use of illicit drugs, excessive alcohol drinking, and long-term exposure to chemicals are the common causes of female infertility.
In term of diet, researchers at the Harvard T.H. Chan School of Public Health in the study "Diet and female fertility: doctor, what should I eat?" wrote, "According to existing data, women trying to achieve pregnancy are encouraged to increase consumption of whole grains, omega-3 fatty acids, fish, and soy and to reduce consumption of trans fats and red meat. In addition, a daily multivitamin that contains folic acid before and during pregnancy may not only prevent birth defects but also improve the chance of achieving and maintaining a pregnancy".
These results suggested that women who follow the diet with high in saturated and trans fat, intake of a large amount of red meat and processed food, and less in fruits, nuts, and vegetables are at a higher risk of infertility or of carrying the pregnancy to full term.
In the concerns of oxygen species (ROS), which are produced during cellular oxidation may reduce the chance of conception, researchers at the joint study led by the Uniwersytet Medyczny w Łodzi. launched an investigation to examine whether increased production of reactive oxygen species is an important factor in the etiopathogenesis of pregnancy and affects female reproduction.
Before the application of green tea s (GrTPs) researchers found that oxidative stress caused by overexpression of free radicals may damage the oocytes and may impair their fertilization capacity.
The increased ROS levels probably are the results of antioxidant enzymes produced by the tested subjects being suppressed due to some unknown mechanisms.
Oxidative stress may also lead to embryo fragmentation and formation of numerous developmental abnormalities and is regarded to be one of the important reasons for spontaneous and recurrent miscarriage
Oral administered green tea polyphenols (GrTPs) inhibits the overexpression of ROS showed to restore the embryo fragmentation and formation of numerous developmental abnormalities and increase the quality of female gametes, mostly via the capability of catechins to reduce ROS production.
Further analysis also suggested that GrTPs processed antioxidant properties that only restores the health of oocytes caused by overexpression of ROS but also improves age-related decline in female fertility rate, and gamete quality.
These unique properties of green tea catechins in improving the female reproductive health suggested green tea polyphenols (GrTPs) may be considered a functional food in protecting against the damage of the oocytes and their fertilization capacity and the integrity of embryo.
Dr, Rahman SU, the lead scientist at the final report, said, "the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals".
Additionally, in the concerns of the Reactive oxygen species (ROS) that may increase the risk of female infertility, researchers launched an investigation to examine whether green tea catechins protect the female gametes over the expression of ROS.
After taking into account levels of oxidative stress before and after application of green tea catechin, researchers wrote,
* Epigallocatechin-3-gallate (EGCG), a major bioactive compound in green tea inhibited the expression of ROS in facilitating the damage of female gametes through to its strong antioxidant activity.
* Green tea catechins potentially improves the oocyte maturation and may inhibit in-vitro maturation of the oocyte
Dr. Roychoudhury S, the lead author said, " (These results furtherly confirmed) the potential roles of green tea catechins on oxidative stress in male and female reproduction and fertility".
Taken altogether, Green tea polyphenols (GrTPs) may be considered an adjunct therapy in the protection of the female gametes and oocyte maturation against the onset of infertility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diet and female fertility: doctor, what should I eat? by Chiu YH1, Chavarro JE2, Souter I. (PubMed)
(2) Potential role of green tea catechins in the management of oxidative stress-associated infertility by Roychoudhury S1, Agarwal A2, Virk G3, Cho CL. (PubMed)
Sunday, July 19, 2020
Herbal Arctostaphylos uva-ursi, the Free Radicals Scavenger Functional Herb
Herbal Arctostaphylos uva-ursi may have a potential effect in reducing the risk and treatment of oxidative stress-related diseases, some studies suggested.
Oxidative stress is a production of the imbalance of ratio of free radicals and antioxidant in the bost body.
The imbalance of the ratio of free radicals and antioxidant in the bost body can be caused either by the overproduction of free radicals or antioxidant enzymes are suppressed by the outside sources.
However, most outside sources that suppress the levels of antioxidant enzymes also play an important role in stimulating the overexpression of free radicals, such as chemical toxins
Free radicals are unstable atoms with the unpaired electron in the outer ring. Therefore, in order for them to become stable, free radical either donates or steals an electron from stable molecules, leading to a chain of reaction that facilitates the onset of oxidative stress.
The chain once starts, it can not stop until the electron on the outer ring is paired or inhibited by antioxidant.
Free radical has been known to cause oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA.
Antioxidants are stable molecules found abundantly in fruits, vegetable, and herbal medicine.
If oxidative stress-related diseases are associated with the overproduction of free radicals, then long-term intake of a healthy diet high in fruits, vegetable and less in red meat and saturated and trans fat and processed foods can reduce the risk of the diseases in the healthy individuals.
Dr. Halliwell B, in the study to reaffirm the effect of healthy dietary patterns against the onset of oxidative stress said, " diet-derived antioxidants may be particularly important in protecting against these diseases" and
"The physiological relevance of these effects is uncertain, as is the optimal intake of most diet-derived antioxidants. In principle, these questions could be addressed by examining the effects of dietary composition and/or antioxidant supplementation upon parameters of oxidative damage in vivo".
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the examining the Dr. Bol'shakova IV, the lead author at the Emanuel Institute of Biochemical Physics claim, that Arctostaphylos uva.processes a significant antioxidant property in the inhibition of free radicals generation, researchers launched an investigation to evaluate the concentration of compound that inhibited cell growth by 50% (IC(50)) of a range of phytochemicals and plant extracts.
All selected extracts were differentiated according to the antioxidant and genoprotective effects under conditions of oxidative stress in U937 cells.
Two phytochemicals-resveratrol and citroflavan-3-ol isolated from the herbal Arctostaphylos uva-ursi demonstrated the highest IC50 value of 13.7 microg/mL, compared to the lowest at 9,400 microg/mL. of Echinacea.
Extract of herbal Arctostaphylos uva-ursi displayed a significant attenuation of the oxidative stress induced by the etoposide injection by inhibiting the expression of H2O2- and tBOOH-induced DNA damage.
These result reconfirmed the findings of Dr. Bol'shakova IV team that herbal Arctostaphylos uva-ursi as a non-nutrient dietary constituent may act as significant bioactive compounds in enhancing the antioxidants activity and stimulating the production of antioxidant enzymes if the herb is administrated in an animal model.
Moreover, Dr.Matsuda H the antioxidant team leader at the Kinki University, Osaka in the finding the natural compounds or whole food with potential antioxidant effects evaluated the inhibitory effect of 50% ethanol extracts obtained from the leaves of six Arctostaphylos plants (A. patula, A. viscida, A. canescens, A. Columbiana, A. nevadensis and A. uva-ursi) (Ericaceae).
Injection of the extracts of A. patula showed potent inhibition against tyrosinase, the enzyme that cause oxidation of the skin pigment.
Also, Arctostaphylos uva-ursi not only inhibited the production of melanin from dopachrome by autoxidation and but reduced the over exhibited SOD (superoxide dismutase, free radical)-like activity.
Additionally, Arctostaphylos uva-ursi processed a moderate absorbance in the UV-B area.
The results not only reaffirm the claim of Dr. Bol'shakova IV suggestion but also introduce a new herbal whitening medicine for the skin.
Taken all together, Herbal Arctostaphylos uva-ursi may be considered a functional food for the prevention and an adjunct therapy combine with primary medicine for the treatment of oxidative-related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Antioxidant properties of plant extracts].[Article in Russian] by Bol'shakova IV, Lozovskaia EL, Sapezhinskiĭ II. (PubMed)
(2) Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells by O'Brien NM, Carpenter R, O'Callaghan YC, O'Grady MN, Kerry JP. (PubMed)
(3) Studies of cuticle drugs from natural sources. IV. Inhibitory effects of some Arctostaphylos plants on melanin biosynthesis. by Matsuda H, Higashino M, Nakai Y, Iinuma M, Kubo M, Lang FA. (PubMed)
Oxidative stress is a production of the imbalance of ratio of free radicals and antioxidant in the bost body.
The imbalance of the ratio of free radicals and antioxidant in the bost body can be caused either by the overproduction of free radicals or antioxidant enzymes are suppressed by the outside sources.
However, most outside sources that suppress the levels of antioxidant enzymes also play an important role in stimulating the overexpression of free radicals, such as chemical toxins
Free radicals are unstable atoms with the unpaired electron in the outer ring. Therefore, in order for them to become stable, free radical either donates or steals an electron from stable molecules, leading to a chain of reaction that facilitates the onset of oxidative stress.
The chain once starts, it can not stop until the electron on the outer ring is paired or inhibited by antioxidant.
Free radical has been known to cause oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA.
Antioxidants are stable molecules found abundantly in fruits, vegetable, and herbal medicine.
If oxidative stress-related diseases are associated with the overproduction of free radicals, then long-term intake of a healthy diet high in fruits, vegetable and less in red meat and saturated and trans fat and processed foods can reduce the risk of the diseases in the healthy individuals.
Dr. Halliwell B, in the study to reaffirm the effect of healthy dietary patterns against the onset of oxidative stress said, " diet-derived antioxidants may be particularly important in protecting against these diseases" and
"The physiological relevance of these effects is uncertain, as is the optimal intake of most diet-derived antioxidants. In principle, these questions could be addressed by examining the effects of dietary composition and/or antioxidant supplementation upon parameters of oxidative damage in vivo".
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the examining the Dr. Bol'shakova IV, the lead author at the Emanuel Institute of Biochemical Physics claim, that Arctostaphylos uva.processes a significant antioxidant property in the inhibition of free radicals generation, researchers launched an investigation to evaluate the concentration of compound that inhibited cell growth by 50% (IC(50)) of a range of phytochemicals and plant extracts.
All selected extracts were differentiated according to the antioxidant and genoprotective effects under conditions of oxidative stress in U937 cells.
Two phytochemicals-resveratrol and citroflavan-3-ol isolated from the herbal Arctostaphylos uva-ursi demonstrated the highest IC50 value of 13.7 microg/mL, compared to the lowest at 9,400 microg/mL. of Echinacea.
Extract of herbal Arctostaphylos uva-ursi displayed a significant attenuation of the oxidative stress induced by the etoposide injection by inhibiting the expression of H2O2- and tBOOH-induced DNA damage.
These result reconfirmed the findings of Dr. Bol'shakova IV team that herbal Arctostaphylos uva-ursi as a non-nutrient dietary constituent may act as significant bioactive compounds in enhancing the antioxidants activity and stimulating the production of antioxidant enzymes if the herb is administrated in an animal model.
Moreover, Dr.Matsuda H the antioxidant team leader at the Kinki University, Osaka in the finding the natural compounds or whole food with potential antioxidant effects evaluated the inhibitory effect of 50% ethanol extracts obtained from the leaves of six Arctostaphylos plants (A. patula, A. viscida, A. canescens, A. Columbiana, A. nevadensis and A. uva-ursi) (Ericaceae).
Injection of the extracts of A. patula showed potent inhibition against tyrosinase, the enzyme that cause oxidation of the skin pigment.
Also, Arctostaphylos uva-ursi not only inhibited the production of melanin from dopachrome by autoxidation and but reduced the over exhibited SOD (superoxide dismutase, free radical)-like activity.
Additionally, Arctostaphylos uva-ursi processed a moderate absorbance in the UV-B area.
The results not only reaffirm the claim of Dr. Bol'shakova IV suggestion but also introduce a new herbal whitening medicine for the skin.
Taken all together, Herbal Arctostaphylos uva-ursi may be considered a functional food for the prevention and an adjunct therapy combine with primary medicine for the treatment of oxidative-related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Antioxidant properties of plant extracts].[Article in Russian] by Bol'shakova IV, Lozovskaia EL, Sapezhinskiĭ II. (PubMed)
(2) Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells by O'Brien NM, Carpenter R, O'Callaghan YC, O'Grady MN, Kerry JP. (PubMed)
(3) Studies of cuticle drugs from natural sources. IV. Inhibitory effects of some Arctostaphylos plants on melanin biosynthesis. by Matsuda H, Higashino M, Nakai Y, Iinuma M, Kubo M, Lang FA. (PubMed)
Saturday, July 18, 2020
Herbal Cascara Sagrada's Emodin Which Inhibits Pancreatic Cancer Cells Against Spreading
Scientists may have found a functional herb bioactive compound which processes anti-pancreatic cancer activity with no side effects, some scientists suggested.
Pancreatic cancer is a medical and chronic condition characterized by irregular cell growth in the tissue of the pancreas.
In the early stage, pancreatic cancer starts on the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.
The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.
Some researchers suggested long-term use of tobacco, being overweight and obese, exposure to workplace chemicals, age, gender, and family history are some prevalent risk factors of pancreatic cancer.
According to the statistic, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men and women. cancer accounts for 7% of all cancer deaths.
The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing effect.
Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the study to reaffirm the Emodin anti-pancreatic cancer effect through inducing apoptosis of pancreatic cancer cells and inhibit tumor growth, researchers at the Zhejiang University School of Medicine, launched an investigation to find out whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism.
In vitro and in vivo Emodin inhibited pancreatic cancer cell growth, induced apoptosis, and enhanced the anti-tumor effect of gemcitabine on pancreatic cancer cells by inhibiting the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), the protein in response to cellular survival
Emodin inhibited tumor angiogenesis in vitro and in implanted pancreatic cancer tissues, decreased the expression of angiogenesis-associated factors, and reduced eNOS phosphorylation in cell proliferation.
However, Emodin had no effect on VEGFR expression in vivo.
Dr. Lin SZ, the lead author said, "emodin has a potential anti-tumor effect on pancreatic cancer via its dual role in the promotion of apoptosis and suppression of angiogenesis".
Additionally, in the examine the effects of an X-linked inhibitor of apoptosis (XIAP) and NF-κB in chemotherapy resistance in pancreatic cancer, researchers conducted an investigation of SW1990 cells treated by sodium chloride, gemcitabine, emodin or their combination (gemcitabine plus emodin).
The combination therapy of gemcitabine plus emodin) is more effective in inducing a significantly inhibited SW1990 cell growth and a higher percentage of apoptosis than monotherapy.
Gemcitabine upregulated the expression of XIAP and NF-κB, while emodin or emodin plus gemcitabine downregulated them compared to the control group in vitro.
In SW1990 cells established orthotopic pancreatic tumor models in nude mice. The combination of emodin and gemcitabine showed a significant reduction in the tumor to tumor (T/NT) ratio, Standardized uptake value (SUV), and tumor weight compared to monotherapy.
Dr. Wang ZH, the lead author after taking into account of co and confounders wrote:" emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo, which may be via the downregulation of NF-κB expression, thus inhibiting the expression of XIAP.".
Taken altogether, herbal Cascara sagrada process high amount of bioactive ingredient Emodon may be considered a function in the prevention and an adjunct therapy combined with chemo intervention of treatment of pancreatic cancer, pending to the results of large example size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
1. Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis by Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL. (PubMed)
2. Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo by Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ.(PubMed)
3. [Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada].[Article in Danish]" by Jacobsen C, Semb S, Kromann-Andersen H(PubMed)
4. "Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity" by Nadir A, Reddy D, Van Thiel DH. (PubMed)
5. "Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana" by Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ. (PubMed)
Pancreatic cancer is a medical and chronic condition characterized by irregular cell growth in the tissue of the pancreas.
In the early stage, pancreatic cancer starts on the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.
The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.
Some researchers suggested long-term use of tobacco, being overweight and obese, exposure to workplace chemicals, age, gender, and family history are some prevalent risk factors of pancreatic cancer.
According to the statistic, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men and women. cancer accounts for 7% of all cancer deaths.
The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing effect.
Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the study to reaffirm the Emodin anti-pancreatic cancer effect through inducing apoptosis of pancreatic cancer cells and inhibit tumor growth, researchers at the Zhejiang University School of Medicine, launched an investigation to find out whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism.
In vitro and in vivo Emodin inhibited pancreatic cancer cell growth, induced apoptosis, and enhanced the anti-tumor effect of gemcitabine on pancreatic cancer cells by inhibiting the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), the protein in response to cellular survival
Emodin inhibited tumor angiogenesis in vitro and in implanted pancreatic cancer tissues, decreased the expression of angiogenesis-associated factors, and reduced eNOS phosphorylation in cell proliferation.
However, Emodin had no effect on VEGFR expression in vivo.
Dr. Lin SZ, the lead author said, "emodin has a potential anti-tumor effect on pancreatic cancer via its dual role in the promotion of apoptosis and suppression of angiogenesis".
Additionally, in the examine the effects of an X-linked inhibitor of apoptosis (XIAP) and NF-κB in chemotherapy resistance in pancreatic cancer, researchers conducted an investigation of SW1990 cells treated by sodium chloride, gemcitabine, emodin or their combination (gemcitabine plus emodin).
The combination therapy of gemcitabine plus emodin) is more effective in inducing a significantly inhibited SW1990 cell growth and a higher percentage of apoptosis than monotherapy.
Gemcitabine upregulated the expression of XIAP and NF-κB, while emodin or emodin plus gemcitabine downregulated them compared to the control group in vitro.
In SW1990 cells established orthotopic pancreatic tumor models in nude mice. The combination of emodin and gemcitabine showed a significant reduction in the tumor to tumor (T/NT) ratio, Standardized uptake value (SUV), and tumor weight compared to monotherapy.
Dr. Wang ZH, the lead author after taking into account of co and confounders wrote:" emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo, which may be via the downregulation of NF-κB expression, thus inhibiting the expression of XIAP.".
Taken altogether, herbal Cascara sagrada process high amount of bioactive ingredient Emodon may be considered a function in the prevention and an adjunct therapy combined with chemo intervention of treatment of pancreatic cancer, pending to the results of large example size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
1. Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis by Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL. (PubMed)
2. Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo by Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ.(PubMed)
3. [Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada].[Article in Danish]" by Jacobsen C, Semb S, Kromann-Andersen H(PubMed)
4. "Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity" by Nadir A, Reddy D, Van Thiel DH. (PubMed)
5. "Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana" by Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ. (PubMed)
Friday, July 17, 2020
Ashwagandha Protects the Liver Against Injury
The liver is the largest internal organ in the human body, played an essential role in filtering blood from the intestine before passing them to other parts of the body.
The organ also produced cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones and vitamins.
Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.
Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases, surgery to stop the bleeding and remove the part of injury may be necessary.
Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue.
The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.
According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.
The most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale or bluish skin.
In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain and swollen and tenderness.
Depending on the degree of injury, patients are either treated with nonoperative management and observation for a full self-recovery or surgery.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention and treatment of liver diseases, researchers examined the effects of withanolides (WA) from Withania somnifera root extract on hepatic toxicity in an animal model
According to the tested analysis, the application of WA profoundly protects wild-type mice but not Nrf2-disrupted mice against APAP hepatotoxicity.
Where Nrf2 is a protein that regulates the expression of antioxidant proteins against oxidative damage.
In vivo and in vitro, WA is a potent inducer of Nrf2-dependent cytoprotective enzyme expression.
In other words, WA protects the liver damage against oxidative stress by enhancing the function by the activation of antioxidant enzyme protein independently to a redox-regulated substrate adaptor protein Keap1 and dependently on pathway associated with limit proliferation in cells.
Taken altogether, Ashwagandha processed a high amount of bioactive compound WA may be considered supplements for the prevention of liver toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms by Palliyaguru DL1, Chartoumpekis DV2, Wakabayashi N2, Skoko JJ2, Yagishita Y2, Singh SV2, Kensler TW. (PubMed)
The organ also produced cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones and vitamins.
Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.
Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases, surgery to stop the bleeding and remove the part of injury may be necessary.
Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue.
The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.
According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.
The most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale or bluish skin.
In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain and swollen and tenderness.
Depending on the degree of injury, patients are either treated with nonoperative management and observation for a full self-recovery or surgery.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention and treatment of liver diseases, researchers examined the effects of withanolides (WA) from Withania somnifera root extract on hepatic toxicity in an animal model
According to the tested analysis, the application of WA profoundly protects wild-type mice but not Nrf2-disrupted mice against APAP hepatotoxicity.
Where Nrf2 is a protein that regulates the expression of antioxidant proteins against oxidative damage.
In vivo and in vitro, WA is a potent inducer of Nrf2-dependent cytoprotective enzyme expression.
In other words, WA protects the liver damage against oxidative stress by enhancing the function by the activation of antioxidant enzyme protein independently to a redox-regulated substrate adaptor protein Keap1 and dependently on pathway associated with limit proliferation in cells.
Taken altogether, Ashwagandha processed a high amount of bioactive compound WA may be considered supplements for the prevention of liver toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms by Palliyaguru DL1, Chartoumpekis DV2, Wakabayashi N2, Skoko JJ2, Yagishita Y2, Singh SV2, Kensler TW. (PubMed)
Thursday, July 16, 2020
Herbal Ashwagandha Inhibits the Parameters Associated with Epilepsy in Vivo
Epilepsy is a neurological disorder associated with sudden recurrent episodes of sensory disturbance, loss of consciousness, or convulsions, caused by abnormal electrical activity in the brain.
Approximately, 1.2 percent of U.S. people have active epilepsy. More than 65 million people have epilepsy globally.
Additionally, about 1 in 26 people will develop epilepsy at some point during their lifetime.
The most common causes of epilepsy are low oxygen during birth, head injuries that occur during birth or from accidents during youth or adulthood, brain tumors, genetic mutation, infections such as meningitis or encephalitis.
The most common symptoms of epilepsy are temporary confusion, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness, and psychic symptoms such as fear, anxiety, or deja vu.
Experimentally, melatonin, a hormone that regulates the sleep-wake cycle. has been found to attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy.
Melatonin also processed additional benefits include improved physical, emotional, cognitive, and social functions.
On the other hand, melatonin has been shown to induce electroencephalographic abnormalities in patients with temporal lobe epilepsy and increase seizure activity in neurologically disabled children.
The hormone showed very low toxicity in clinical practice, according to the study by the Department of Pathophysiology, Medical University, PL 20-090 Lublin, Jaczewskiego 8, Poland(22).
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the management of the neurological disorder, researchers investigated the effect of Withania somnifera (WS) root extract and withanolide A (WA) in the management of temporal lobe epilepsy.
According to the tested analysis, in the epileptic test group of rats, levels of antioxidants are found to substantially decrease compared to the increase of the levels of peroxide.
Oxidative stress caused by an imbalance of the ratio of antioxidants and free radicals in the tested rats, induced significant decrease levels of proteins associated with systemic inflammation, compared to the increase of pro-apoptotic proteins.
Moreover, the epileptic condition of the tested rats also showed to increase the muscarinic receptor binding, which leads to reduced function of transduction of cholinergic signals and increases mRNA expression involved of the inhibition of the cell growth in the cerebral cortex.
However, the administration of the WS reversed the altered muscarinic receptor expression, oxidative stress, and resultant derailment in cell signaling in experimental rats.
Based on the findings, researchers said, "Withania somnifera and withanolide A play important roles in central muscarinic receptor functional balance and activation of the antioxidant system in the cerebral cortex in temporal lobe epilepsy".
Taken altogether, Ashwagandha may be considered supplements for the management of epilepsy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Altered muscarinic receptor expression in the cerebral cortex of epileptic rats: restorative role of Withania somnifera by Anju TR1, Smijin S2, Jobin M3, Paulose CS. (PubMed)
(2) Melatonin in experimental seizures and epilepsy by Banach M1, Gurdziel E, Jędrych M, Borowicz KK. (PubMed)
Approximately, 1.2 percent of U.S. people have active epilepsy. More than 65 million people have epilepsy globally.
Additionally, about 1 in 26 people will develop epilepsy at some point during their lifetime.
The most common causes of epilepsy are low oxygen during birth, head injuries that occur during birth or from accidents during youth or adulthood, brain tumors, genetic mutation, infections such as meningitis or encephalitis.
The most common symptoms of epilepsy are temporary confusion, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness, and psychic symptoms such as fear, anxiety, or deja vu.
Experimentally, melatonin, a hormone that regulates the sleep-wake cycle. has been found to attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy.
Melatonin also processed additional benefits include improved physical, emotional, cognitive, and social functions.
On the other hand, melatonin has been shown to induce electroencephalographic abnormalities in patients with temporal lobe epilepsy and increase seizure activity in neurologically disabled children.
The hormone showed very low toxicity in clinical practice, according to the study by the Department of Pathophysiology, Medical University, PL 20-090 Lublin, Jaczewskiego 8, Poland(22).
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the management of the neurological disorder, researchers investigated the effect of Withania somnifera (WS) root extract and withanolide A (WA) in the management of temporal lobe epilepsy.
According to the tested analysis, in the epileptic test group of rats, levels of antioxidants are found to substantially decrease compared to the increase of the levels of peroxide.
Oxidative stress caused by an imbalance of the ratio of antioxidants and free radicals in the tested rats, induced significant decrease levels of proteins associated with systemic inflammation, compared to the increase of pro-apoptotic proteins.
Moreover, the epileptic condition of the tested rats also showed to increase the muscarinic receptor binding, which leads to reduced function of transduction of cholinergic signals and increases mRNA expression involved of the inhibition of the cell growth in the cerebral cortex.
However, the administration of the WS reversed the altered muscarinic receptor expression, oxidative stress, and resultant derailment in cell signaling in experimental rats.
Based on the findings, researchers said, "Withania somnifera and withanolide A play important roles in central muscarinic receptor functional balance and activation of the antioxidant system in the cerebral cortex in temporal lobe epilepsy".
Taken altogether, Ashwagandha may be considered supplements for the management of epilepsy, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Altered muscarinic receptor expression in the cerebral cortex of epileptic rats: restorative role of Withania somnifera by Anju TR1, Smijin S2, Jobin M3, Paulose CS. (PubMed)
(2) Melatonin in experimental seizures and epilepsy by Banach M1, Gurdziel E, Jędrych M, Borowicz KK. (PubMed)
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