Herbal Fennel Causes the Apoptosis of Cancer Cells, Scientists Show

Kyle J. Norton

Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.

Cell death is a natural process to warrant the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.

However, some microorganisms are found to process the activity in triggering cell death for their own survival.

Apoptosis, or programmed cell death, is a function of the immune system that evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection

Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.


Some herbal medicine such as fennel was shown to induce the function of overexpression of levels of free radical in initiating cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.

Fennel (Foeniculum vulgare) is a plant species of genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...

In the study to investigated several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukaemia, J-45.01—human acute T cell leukaemia, EOL—human eosinophilic leukaemia, HL-60—human Caucasian promyelocytic leukaemia, 1301—human T cell leukaemia lymphoblast, C-8166—human T cell leukaemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. Vulgare shows the highest mortality in Trypan blue test for J45 cell line with 4% of viable cells and a C8166 cell line with 100% of mortality.

* The extract also shows the highest viability in other cell lines, including the HL60 with 60%, EOLwith 48%, and ML1 with 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.

Furthermore, the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.

Application of fennel showed to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.

Fennel induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI-assay.


More importantly, the application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane and increased levels of caspase-9 & caspase-3, and DNA fragmentation in the promotion of MCF-7 cells death.experiment


Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".

Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.

* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.

Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.

Taken all together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for the treatment of cancers


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)

Herbal Turmeric Effects on Skin Health

Skin, the large external organ in the human body is the outer layer, with a total area of about 20 square feet which protects the internal organs, bones, and tissues against damage.

The skin processes 3 main layers

* Epidermis is the outermost layer of the skin providing a barrier against infection from environmental pathogens. The outer layers also regulate the amount of water released from the body through transepidermal water loss.

* Dermis is the second layer of skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures.


* The bottom layer is the subcutaneous fat which has been found to process the protective effect against the dangers of visceral fat.

Skin health refers to the use of material or agents, including topical and oral herbal remedies with the function to protect the skin cell against the environmentally harmful substances, including sun UV light, and microbial infection.

Some researchers suggested that by providing enough nutrition to the skin cells we can maintain healthy skin. In other words, macronutrients including carbohydrates, proteins, and lipids and micronutrients such as vitamins and essential minerals all work together to maintain healthy skin.


More precisely, we can maintain healthy skin by eating a healthy diet accompanied by moderate exercise and avoid exposure of skin to harmful substances.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.


The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural compound for the enhancement of skin health, researchers examined the active component of turmeric, curcumin used medically to treat a variety of dermatologic diseases in traditional medicine.

The search involved the relationship between products containing turmeric, curcumin, and skin health in the medical databases of PubMed and Embase databases found a total of 234 articles with only 18 studies met inclusion criteria.

According to the identified studies, ingestion, topical use, and combined ingestion and topical use showed a statistically significant improvement in skin disease severity in the turmeric/curcumin treatment groups compared with control groups, including conditions of acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo.


Dr. Vaughn AR, the lead scientist after taking into account co and confounder wrote on the final report, "Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health".

In order to reveal more information about curcumin in skin protection, researchers investigated the antioxidative, anti-inflammatory, and antibacterial properties against skin diseases.

According to the tested assays, curcumin exerted protective effects against skin damage caused by chronic ultraviolet B radiation.

Curcumin application also has a strong effect on the protection against skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer.


Taken altogether, turmeric may be considered a supplement for skin health with no side effects, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence by Vaughn AR1, Branum A2, Sivamani RK. (PubMed)
(2) Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review by Panahi Y1, Fazlolahzadeh O2, Atkin SL3, Majeed M4, Butler AE5, Johnston TP6, Sahebkar A. (PubMed)

Herbal Fennel Protects Cell DNA Integrity Against Breast Cancer, Online Medical Literature Revealed

Fennel may have a potential and therapeutic effect in reducing the risk and treatment of breast cancer, some scientists suggested.

Breast cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the breast tissue. At the later stage, cancerous cells may travel a distance away to infect other healthy tissue and organs.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In the evaluation of the essential oil extracted from fennel activity in human breast cancer cell line (MDA-Mb), researchers found that application of fennel extract exerted a significant effect in inhibition of the expression of cancer cell line at a dose of lower than flower than 10 μg/mL with IC50.

According to the University of Malaya in the investigation of the DNA protecting activity and inhibition of nicotine-induced cancer cell migration of 9 spices, fennel exerted a potential effect in the protection of the DNA integrity and inhibition of nicotine-induced cancer cell migration against Murine fibroblasts (3T3-L1) and human breast cancer (MCF-7) cells pre-treated with spice extracts and then exposed to H₂O₂ and nicotine.

Additional analysis suggested that the result of inhibition was attributed to fennel antioxidants of phenols and flavonoids in ameliorated H2O2 in initiated chain activity in the induction of cytotoxicity in altered DNA of the experiment cell line.

Some researchers suggested that overproduction of hydrogen peroxide may serve as a prodrug in the presence of transition metal ions, in induced production of highly reactive hydroxyl radicals to initiated DNA damage in precipitated apoptosis.

In other words, the application of highly oxidative hydrogen peroxide in the breast cancer cell line may cause a significant cytotoxic effect in cancer cell death.

These results demonstrated the correlation of the increase of apoptosis with the rise in generation of reactive oxygen species in cancer cells.

Due to this potential activity, some researchers suggested that hydrogen peroxide overproduced in tumor cells can serve as a prodrug for the treatment of cancer.

On the other hand, the application of H2O2 in healthy cells may induce DNA damage in the initiation of cancer cell development.

Furthermore, fennel scored a statistically significant DNA protecting activity in comparison to other spices, such as ginger with 50 μg/ml in reduced 68% of DNA damage in 3T3-L1 cells.

However, Fennel exerted a lesser effect in inhibited cancer MCF-7 cells with nicotine-induced cell migration in comparison to other spices such as pepper, long pepper, and ginger.

The above differentiation was supported by the joint study led by the Avicenna Tajik State Medical University, in the evaluation of the antioxidant effect of essential oil of fennel (Foeniculum vulgare) against MCF-7 (human breast adenocarcinoma).
According to the result from Gas chromatographic-mass spectrometric analysis, fennel displayed a moderated antioxidant in precipitated cytotoxic activity against MCF-7 (human breast adenocarcinoma) with IC50 values between 30-210 mg L-1 in comparison to cytotoxic reference compounds.
In fact, the efficacy of fennel essential oil in inhibiting breast cancer proliferation and migration was attributed to the presence of lipophilic secondary metabolites and anise aldehyde, which have the potential in elevated the interference with molecular targets in cells by fennel antioxidant compounds such as anethole.

Taken together, fennel and its bioactive compound may be considered functional foods in reduced risk, progression, and treatment of breast cancer. However, intake of fennel supplement should be taken with extreme care in preventing liver acute toxicity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran by Akhbari M1, Kord R1, Jafari Nodooshan S2, Hamedi S3.(PubMed)
(2) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8.(PubMed)
(3) Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration by Jayakumar R1, Kanthimathi MS.(PubMed)

Herbal Angelica, Processes Apoptotic and Anti Proliferative Function in Vitro

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.


Over time, the alternative cells induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some points during their lifetimes, according to the data from 2013–2015.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.


In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.

In the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.

A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.

In the programmed cell death gene, such as BCL-2 induce cell death by either inducing apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.

In phytochemicals, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the prevention and treatment of cancer, researchers examined the effects of Angelica phytochemical (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone from A. purpuraefolia on cell proliferation and apoptotic cell death.


In 4 breast (MDA-MB-231, MCF-7, HS578T, and T47D), three cervical (HeLa, SiHa, and C33A) cancer cell lines, and NIH 3T3 normal cells used for the experiment, researchers found that
* (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone treatment suppresses the growth and proliferation of cancer cells at a relatively low concentration (<10 μg/ml).



* The phytochemical also induces cancer cell apoptosis at a high concentration (>50 μg/ml).

* At the concentration of 10 μg/ml, the chemical compounds also exerted a strong cell cycle arrest in the S/G2 phase.


Furthermore, according to the Western blot analysis, the concentration higher than 50 μg/ml of (+)-4'-decanoyl-cis-khellactone increased the large percentage of apoptotic cells in a time-dependent manner.


Interestingly, while the (+)-4'-decanoyl-cis-khellactone using both extrinsic and intrinsic pathways to induce apoptosis, the but (+)-3'-decanoyl-cis-khellactone uses only an intrinsic pathway for the same results.



In other words, the (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone also inhibited the in vitro proliferation of six other human breast and cervical cancer cell lines with different pathways.


Based on the evidence, researchers said, "Our data strongly suggest that (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone act as an anti-cancer supplement particularly against breast and cervical cancers by inducing cell cycle arrest in the S/G2 phase and caspase-dependent apoptosis at relatively low and high concentrations, respectively".



Taken altogether, Herbal Angelica processes anti-proliferative activity against cancer, pending larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effect and mechanism on antiproliferation of khellactone derivatives from herbal suitable for medical or food uses by Jung S1, Li C, Lee S, Ohk J, Kim SK, Lee MS, Moon HI. (PubMed)

Dandelion(Taraxacum officinale), a Natural Anticoagulant Activity

Platelet aggregation refers to the platelet-to-platelet adhesion in the blood that forms a clot.
Platelet aggregation plays a critical role in the protection of the body against blood loss due to injury or tissue damage.

In other words, platelet aggregation is a natural reaction of the wound healing process of blood clotting in damage and injure of our body, to prevent infection and inflammation.


However, activated platelets that stimulate blood clot formation have also been found to induce atherothrombotic disease.

Antiplatelet aggregation medicines, also known as platelet agglutination inhibitors are the types of medicine that process blood-thinning properties.

Diseases associated with low and abnormal blood platelet include
* Thrombocytopenia is a condition characterized by low blood platelet due to abnormal function of the bone marrow that makes platelets. patients with thrombocytopenia due to the low quantity of blood platelets may experience symptoms of a bruise, internal bleeding, nosebleed.

Long-term untreated thrombocytopenia has been found to increase the risk of cancer, liver disease, pregnancy, infections, and an abnormal immune system.

* Essential thrombocythemia is a disease associated with overproducing blood platelets by the bone marrow, leading to symptoms of blood clots that form and block the blood supply to the brain or the heart.

* Secondary thrombocytosis is also another condition caused by too many platelets produced by the bone marrow.

In other words, antiplatelet aggregation medicines reduce the risk of blood clotting used in patients who have a high risk of cardiovascular disease such as aspirin.

Coagulation disorders or bleeding disorders are medical conditions that affect blood clotting activities. The most common diseases associated with coagulation disorders are Hemophilia, Von Willebrand disease, clotting factor deficiencies, hypercoagulable states, and deep venous thrombosis.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of diseases involved in oxidative stress, scientists examined the n-hexane soluble compounds from aerial parts of dandelion (Taraxacum officinale Weber ex F.H. Wigg) antioxidant activity.

Based on the results, researchers suggest, "This fraction demonstrated insignificant antimicrobial activity and can be used in cosmetic and pharmaceutical industries".


Taken altogether, Dandelion may be considered an antioxidant remedy for the protection of oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anticoagulant from Taraxacum platycarpum by Yun SI1, Cho HR, Choi HS. (PubMed)

Herbal Chaste Tree Berry (Seeds) in Relieving the Symptoms, and Treatment of Arthritis

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Arthritis, a common condition of pain and inflammation in the joints, the tissues, affects 54 million people in the US annually alone, according to the 2013-15 statistics.

In Freund's complete adjuvant (CFA) induced arthritis (AA) in a rat model. oral administration of treatment of Chaste Tree Berry seed expressed a strongly inhibited paw edema, reversed weight loss, and decreased arthritis score.


According to the Second Military Medical University, the efficacy of herbal medicine for the treatment of arthritis is the result in inhibition of pro-inflammatory cytokines and in the regulation of enzymes responsible for inflammation and pain. expression.

In support of the above, researchers in the examined histopathological studies found that Chaste Tree Berry showed a remarkable inhibition effect in decreased synovial inflammatory infiltration and synovial lining hyperplasia in the joints in animal models.

Some also researchers suggested that Chaste tree berry reduced symptoms of the pain of arthritis patients probably is associated with the blocking the stimulus by sensory neurons ability through mediating anti-inflammatory activity and interacted with the opioid system.



Taking together, Chaste Tree Berry (seed) processed analgesic properties may be used as therapeutic potential in ameliorated symptoms and treatment of inflammatory arthritis. A large amount intake can only be prescribed by herbalists.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant-induced arthritis in rats by Zheng CJ1, Zhao XX1, Ai HW1, Lin B1, Han T1, Jiang YP1, Xing X2, Qin LP3. (PubMed)
(2) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)

The Herbal Angelica Effects on Osteoporosis

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

The condition is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries and considered as a major health problem in both elderly men and women.


Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.

Osteoporosis is a common disease among the elderly, probably due to the aging effect that induces nutrition deficiency such as
* Vitamin D insufficiency and reduced calcium absorption,

* Reduced hormone production, the drop of estrogen levels after menopause, can speed up bone loss.

* Reduced production of bone mass and increased bone reabsorption due to the balance shifts in favor of osteoclasts compared to those of osteoblasts.


Osteoclastogenesis is a procedure that included many stages, that interfere with the specific stage of the process, diseases associated with imbalanced osteoclasts, and osteoblast that may be preventable in the future.

The osteoclast is a type of cell differentiated from another type of cell called a macrophage that breaks down the bone that leads to bone resorption.

In other words, in osteoporotic patients, bone resorption is far more exceedingly to bone formation.

Furthermore, the imbalance of osteoclasts and osteoblast also is found in patients with Paget's disease, rheumatoid arthritis, osteopetrosis, periodontal disease, and bone cancer metastases.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the improvement of bone mineral density, researchers examined the phytochemical Ligustilide (LIG), the main component of A. sinensis anti-osteoporotic effects.


According to the tested analysis, LIG significantly ameliorated inhibition of bone formation in zebrafish caused by prednisolone.


Furthermore, the application also showed a strongly promoted osteoblast differentiation, including that of the pre-osteoblastic cell line MC3T3-E1 and bone marrow mesenchymal stem cells by reducing the oxidative stress to induce cell apoptosis by free radical H2O2 and enhancing the protein (Bcl-2) associated with anti-apoptotic functioning


The promotion of bone density of LIG was also found to induce the metabolic reaction of EGFR and ERK1/2 associated with instructions for making a receptor protein involved in bone formation by blocking the GPR30 signaling to induce bone mass increasing.

Collectively, researchers said, "the results reveal that GPR30 is a positive switch for LIG to increase bone formation via regulation of EGFR, and these results provide evidence for the potential of LIG to treat osteoporosis".

Taken altogether, Herbal Angelica consists of LIG. maybe considered a functional herbal medicine for reducing the risk of osteoporosis, pending a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway by Yang F1,2, Lin ZW1,2, Huang TY1,2, Chen TT1,2, Cui J1,2, Li MY1,2, Hua YQ. (PubMed)