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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Treatments
A. In herbal medicine perspective
5. Bacopa
Commonly known as Waterhyssop or Water Hyssop, the herb is a semi-woody plants, genus of Hyssopus, belonging to the family Lamiaceae, native to the east Mediterranean
to central Asia, used in traditional medicine as an
antibiotic(660)(659), carminative, antispasmodic, antifungal(661), and
antiseptic(661)(662) agent and to treat bronchitis(663), asthma(664),
digestive ailments(665)(668), insomnia(666), diabetes(667),
edema(669)(670), etc.
a. Increases Cerebral Blood Flow
In cerebral blood flow (CBF), Bacopa monnieri's promoting blood flow through its procognitive effect in comparison via dose-dependent hypotensive actions (671), with Ginkgo biloba and donepezil(671)may be a potential attenuation of dementia, Parkinson's disease, and epilepsy(672).
a. Increases Cerebral Blood Flow
In cerebral blood flow (CBF), Bacopa monnieri's promoting blood flow through its procognitive effect in comparison via dose-dependent hypotensive actions (671), with Ginkgo biloba and donepezil(671)may be a potential attenuation of dementia, Parkinson's disease, and epilepsy(672).
b. Ethnobotanical treatment
Bacopa, ethnobotanically, may be used as brain tonification(676) and to treat various diseases(673), including Alzheimer's disease
through its phytochemicals in alleviation of AD
pathology and associated symptoms(674). According to university System
HSC College of Medicine, Bacopa monniera
extract (BME), administered starting at 2 months of age for either 2 or 8
months on test mice, significant lowers Abeta 1-40 and 1-42 levels in
cortex by as much as 60%, and reverses Y-maze performance and open field
hyperlocomotion behavioral changes(675). Its natural products
(galantamine and rivastigmine), also has been used pharmaceutically for
cognitive and behavioural and psychological symptoms of dementia (BPSD)(673).
c. Cognitive performance, anxiety, and depression
c. Cognitive performance, anxiety, and depression
In olfactory bulbectomized mice, alcoholic extract of Bacopa monnieri
(L.) showed to ameliorate memory and emotional deficits(678) and
enhanced cognitive performance(679) through its protection of
cholinergic systems from OBX-induced neuronal damage(677). In normal
healthy participants, the herb also attenuated stress reactivity and
mood, through its adaptogenic and nootropic effects, probably via
reduction in cortisol levels(680). According to National College of
Natural Medicine, standardized dry extract of Bacopa
monnieri, promoted the improvement depression scores, combined state
plus trait anxiety scores,with few adverse events, primarily
stomach(681)
d. Etc.
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d. Etc.
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