Sunday, January 15, 2017

Hormone Estrogen and Sex Hormone Binding Globulin

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     


Estrogen is a female sex hormone defined as a group of compounds for its function in regulating in the estrous cycle of women after puberty.

     Hormone Estrogen - and Sex Hormone Binding Globulin 

SHBG is a glycoprotein, produced by the liver to bind to sex hormones testosterone and estradiol. In an abstract of the study of "The ability of hydroxylated estrogens (2-OH-E2 and 4-OH-E2) to increase of SHBG gene, protein expression and intracellular levels in MCF-7 cells line" by Gregoraszczuk EL, Ptak A, Wrobel A., posted in PubMed, researchers filed the result that 4-OH-E2 in high doses and 2-OH-E2 in the highest dose, while 17β-estradiol in all doses used increased intracellular but not extracellular SHBG levels. Both metabolites increased SHBG mRNA expression, the rank order of potency being E2 > 4-OH-E2 > 2-OH-E2. Both E2 and its metabolites increased SHBG protein expression.
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