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Wednesday, March 29, 2017

Hormone Serotonin or 5-hydroxytryptamine (5-HT); Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

          Hormone Serotonin or 5-hydroxytryptamine (5-HT) 

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter derived from tryptophan, primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS). In Gut, serotonin regulates intestinal movements, in CNS, it regulates mood, appetite, sleep, memory and learning, etc.


     Hormone Serotonin or 5-hydroxytryptamine (5-HT); Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems 




In the study to review the neuroactive steroid effects on serotonin and GABA systems, along with the subsequent effects on cognitive functions, showed that Estrogen alone, or in combination with progesterone, affects the brain serotoninsystem differently in different parts of the brain, which can at least partly explain the opposite effects on mood of those hormones. Many of the progesterone effects in the brain are mediated by its metabolite allopregnanolone. Allopregnanolone, by changing GABA(A) receptor expression or sensitivity, is involved in premenstrual mood changes; and it also induces cognitive deficits, such as spatial-learning impairment(9).


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Source
(9) http://www.ncbi.nlm.nih.gov/pubmed/16368148

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