Saturday, November 18, 2017

Hormone Dopamine: Acetylcholine-dopamine and CNS disorders

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

                        Hormone Catecholamines


Catecholamines, derived from the amino acid tyrosine, produced by the adrenal glands, which are found on top of the kidneys. are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. The hormone are released into the blood during times of physical or emotional stress.

     Hormone Dopamine: Acetylcholine-dopamine and CNS disorders


The substantia nigra pars compacta and ventral tegmental area of midbrain dopaminergic nuclei and their respective forebrain and cortical target areas are well established as serving a critical role in mediating voluntary motor control, as evidenced in Parkinson's disease, and incentive-motivated behaviors and cognitive functions, as exhibited in drug addiction and schizophrenia, respectively. According to the study by The University of Memphis, acetylcholine may be as important in regulating dopaminergic transmission. Midbrain dopaminergic cell tonic and phasic activity is closely dependent upon projections from hindbrain pedunculopontine and the laterodorsal tegmental nuclei, which comprises the only known cholinergic inputs to these neurons(1). Other study indicated that combinatorial signaling through dopamine and serotonin (DA and 5-HT) receptors can regulate the brain region- and cell-type specific pMeCP2 in the CNS(1a).


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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20370804
(1a) http://www.ncbi.nlm.nih.gov/pubmed/21956448

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