Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in children and young adults, leading to difficulty breathing and coughing up mucus due to frequent lung infections.
However, the condition has also been found in the pancreas, liver, kidneys, and intestine.
According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.
Believe it or not, most cases of CF are diagnosed by age 2.
The most common symptoms are depending on the location of cystic fibrosis including
sinus infections, poor growth, fatty stool, clubbing of the fingers and toes.
In male adults, the condition also induces infertility as a result of the blockage or absence of the sperm canal.
Conventionally, as of today, there is no cure for CF. Most cases of CF caused by lung infection are treated intravenously, inhaled, or by mouth.
In severe cases, a lung transplant may be the only option.
Although most cases of CF are associated with a genetic preposition, environment, lifestyle, and age are also 2 main factors that increase the risk of CF.
According to statistics provided by the Canadian Cystic Fibrosis Foundation, approximately 1 in every 3,600 children born in Canada has CF.
In age perspective,
* 60% of patients are diagnosed in the first year of life, and 90% by 10 years of age.
* More than 47% of all Canadians with CF are over the age of 18 years.
* As of 2002, the median age of survival of Canadians with CF is 37 years of age.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the treatment of diseases associated with genetic disorders, researchers examined the effects of Withaferin A (WFA), a steroidal lactone from the plant Withania Somnifera L. Dunal on cystic fibrosis.
According to the tested analysis, WFA blocks platelet-activating factor (PAF)-induced activation of NFκB in the induction of inflammation through the innate immune cells and inflammatory T cells.
More precisely, WFA inhibited the NFκB activation that leads to a reduction of the increased expression of IL-8 and NFκB subunit p65 translocation involved in inflammation.
In other words, WFA demonstrated anti-inflammatory activity in the cystic fibrosis model.
Based on the evidence, researchers said, "the airways of CF patients can be specifically targeted for delivery of therapeutics, we propose that WFA should be further studied as an anti-inflammatory agent in models of CF-related inflammation mediated by NFκB".
Taken altogether, Ashwagandha processed a high amount of bioactive compound WFA may be considered supplements for the treatment of cystic fibrosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation by Rangan Maitra, Melissa A Porter, Shan Huang & Brian P Gilmour (BMC)
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