Chaste tree berry may process a strong effect in reduced risk of free radical progression in inducing various diseases, the renowned institute suggested.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
Antioxidants are chemical compound with function in inhibited oxidation caused by production of free radicals with an aim to reduce risk of oxidative damage to our body.
According to the Faculty of Pharmacy, Ege University, in the observation of the chemical activity of different preparations of Chaste tree berry, researchers showed that water and ethanol extract content are far stronger antioxidant activity in compared n-hexane extracts.
In vitro antioxidant assays, the newly differentiated ingredients isolated from the Chaste tree berry, EtOAc extract displayed a significant antioxidant property in reduced free radicals caused by brain homogenate. at the concentration-dependent effect tested by 1,1-diphenyl-2-picrylhydrasyl (DPPH) free radical assay (IC(50) = 68 microg/mL) in compared fractions of MeOH-H(2)O and n-hexane fraction.
The study also suggested that the efficacy of antioxidant effect in the extract may have resulted from the recently discovered phytochemicals, flavonoid constituents EtOAc extract, casticin, vitexin, and orientin as viewed in the tested essay.
More importantly, in support of the above differentiation, a study of mice subcutaneously injected with d-galactose (500 mg/kg/d for 45 days) induced aging and natural aging. administrated extract of Vitex (600 mg/kg/bid for 7 days by gavage) to 72 female NMRI mice (48 3-month-old normal mice and 24 18-24-month-old mice), weighing 30-35 g randomly divided into six groups: control, Vitex, d-galactose, Vitex + d-galactose, Aging, and Vitex + Aging, groups treated with chaste tree berry expressed a superior effect in restored estrous cycle and damage of uterus and ovarian tissues, through antioxidant activities in ameliorated oxidative stress and aging diseases.
Truly, mice treated with extract of Chaste tree berry only showed a reduced presence of free radicals but also improved hormone expression in natural and d-galactose induced aging.
Taking together, there is no doubt that Chaste tree berry displayed a significant antioxidant potential in ameliorated risk of free radical in induced chronic diseases, but a large amount of intake should be taken with care.
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Sources
(1) Antioxidant activity of Vitex agnus-castus L. extracts by Sağlam H1, Pabuçcuoğlu A, Kivçak B.(PubMed)
(2) Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidantactivity of the fruit extracts and their constituents by Hajdú Z1, Hohmann J, Forgo P, Martinek T, Dervarics M, Zupkó I, Falkay G, Cossuta D, Máthé I.(PubMed)
(3) Effects of Vitex agnus-castus fruit on sex hormones and antioxidant indices in a d-galactose-induced aging female mouse model by Ahangarpour A1, Najimi SA2, Farbood Y3.(PubMed)
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