Chaste Tree Berry, the Best MALE Osteoprotective Natural Medicine

Chaste tree berry is found to processability in reduced of MALE osteopenia turnover, the early sign of osteoporosis, a renowned institution study reported.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of times.

In a total of 60, 3-month-old male rats orchidectomized and divided into five groups with each group either received soy-free food (C), estradiol (E), testosterone (T) or Vitex agnus castus in different concentrations (AC high/AC low) for 12 weeks, rats treated with Vitex agnus castus at highest dose displayed a recover of 88.4% of trabecular bone area, 80.7% of trabecular number and 66.9% of the number of trabecular nodes compared with other administrations.
The study also found out that Vitex agnus castus is more protective in treating osteoprorsis in male population in compared female counter part.


Dr. Sehmisch S, the lead author said, " Vitex agnus castus demonstrated osteoprotective effects in males. It preserves the cortical as well as the trabecular bone and might be a safe alternative for HRT".

Further more, In the study to compare group of animals (n = 8) treated subcutaneously (s.c.) with 60 mg/kg of Vac essential oil once a day for 3 weeks and control animals (n = 8) received sterile olive oil s.c. by the same schedule, Vitex agnus-castus L. (Vac) essential oil treated group also exerted a significant bone metabolism in 16-month-old male Wistar rats.

The osteoporosis protection can be observed through the lower of Serum osteocalcin (OC) and calcium (Ca2+) in Vitex agnus-castus L. (Vac) essential oil and decreased of bone turnover treated group in compared control in middle-aged male rats..

Taking together, Chaste tree berry showed a strong support in reduced early onset of osteoporosis of male gander through improved bone metabolism and calcium status, but further large size and multi centers studies are necessary to validate this potency.



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Sources
(1) Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation by Sehmisch S1, Boeckhoff J, Wille J, Seidlova-Wuttke D, Rack T, Tezval M, Wuttke W, Stuermer KM, Stuermer EK.(PubMed)
(2) Vitex agnus-castus essential oil affects thyroid C cells and bone metabolism in middle-aged male rats (Researchgate)

Herbal Chaste Tree Berry The Best Antioxidant for Prevention and Treatment of Aging Chronic Diseases

Chaste tree berry may process a strong effect in reduced risk of free radical progression in inducing various diseases, the renowned institute suggested.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Antioxidants are chemical compound with function in inhibited oxidation caused by production of free radicals with an aim to reduce risk of oxidative damage to our body.

According to the Faculty of Pharmacy, Ege University, in the observation of the chemical activity of different preparations of Chaste tree berry, researchers showed that water and ethanol extract content are far stronger antioxidant activity in compared n-hexane extracts.

In vitro antioxidant assays, the newly differentiated ingredients isolated from the Chaste tree berry, EtOAc extract displayed a significant antioxidant property in reduced free radicals caused by brain homogenate. at the concentration-dependent effect tested by 1,1-diphenyl-2-picrylhydrasyl (DPPH) free radical assay (IC(50) = 68 microg/mL) in compared fractions of MeOH-H(2)O and n-hexane fraction.

The study also suggested that the efficacy of antioxidant effect in the extract may have resulted from the recently discovered phytochemicals, flavonoid constituents EtOAc extract, casticin, vitexin, and orientin as viewed in the tested essay.

More importantly, in support of the above differentiation, a study of mice subcutaneously injected with d-galactose (500 mg/kg/d for 45 days) induced aging and natural aging. administrated extract of Vitex (600 mg/kg/bid for 7 days by gavage) to 72 female NMRI mice (48 3-month-old normal mice and 24 18-24-month-old mice), weighing 30-35 g randomly divided into six groups: control, Vitex, d-galactose, Vitex + d-galactose, Aging, and Vitex + Aging, groups treated with chaste tree berry expressed a superior effect in restored estrous cycle and damage of uterus and ovarian tissues, through antioxidant activities in ameliorated oxidative stress and aging diseases.

Truly, mice treated with extract of Chaste tree berry only showed a reduced presence of free radicals but also improved hormone expression in natural and d-galactose induced aging.

Taking together, there is no doubt that Chaste tree berry displayed a significant antioxidant potential in ameliorated risk of free radical in induced chronic diseases, but a large amount of intake should be taken with care.


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Sources
(1) Antioxidant activity of Vitex agnus-castus L. extracts by Sağlam H1, Pabuçcuoğlu A, Kivçak B.(PubMed)
(2) Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidantactivity of the fruit extracts and their constituents by Hajdú Z1, Hohmann J, Forgo P, Martinek T, Dervarics M, Zupkó I, Falkay G, Cossuta D, Máthé I.(PubMed)
(3) Effects of Vitex agnus-castus fruit on sex hormones and antioxidant indices in a d-galactose-induced aging female mouse model by Ahangarpour A1, Najimi SA2, Farbood Y3.(PubMed)

Chaste Tree Berry The Best Anticonvulsant Herbal Medicine

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

In a study using animal model of maximal electroshock seizures (MES) and induced seizures (MES) by administrated pentylenetetarazole (PTZ), intake of ethanolic leaf extract of Vitex-negundo, at doses of 250, 500 and 1000 mg/kg p.o, exerted a significant of postictal depression, an altered state of consciousness after an epileptic seizure in the dose of 1000 mg/kg body weight in comparison to control but no effects in other applications.

At doses of (1000 mg/kg, po), the ethanolic leaf extract exhibited a 50% half-life protection in chronic seizures after 24-hour injection against PTZ induced seizures. Researchers also found that the efficacy of the extract at that doses is the result of valproic acid, a major ingredient found in Chaste tree berry.

Dr. Tandon VR and co-author Dr. Gupta RK. of the study said, " The anticonvulsant activity of Vitex-negundo has not been found quite effective with standard drugs".




Furthermore, because of the potentiation of diphenylhydantoin and valporic acid isolated Vitex-negundo displayed a significant effect in treating animal models, the extract may be used as an adjuvant therapy along with standard anticonvulsants.

Additionally, according to the Baqiyatallah University of Medical Sciences, hydrophilic extract of Vitex agnus castus fruit (Vitex) administered doses (60, 120 or 180 mg/kg) showed a strong anticonvulsant activity even at low dose (60 mg/kg) of Vitex by increasing the afterdischarge(AD) threshold and decrease the afterdischarge duration ( ADD) and and stage 5 duration (S5D).


Promisingly, at the highest dose, the extract inhibited significantly the seizure stage (P<0.01) and reduced or prevented epileptic activity as demonstrated by reduction of ADD and S5D (length of convulsion) in a dose-dependent manner.

More importantly, methanolic extract (ME) of the leaves of V. negundo salso showed to process the analgesic properties and potentiated analgesia demonstrated by morphine and pethidine in protection against strychnine and leptazole induced convulsions.

Taking together, Chaste Tree Berry may be one of the next-generation therapeutic herbal medicine consisted a strong effect for prevention and treatment of seizure as a result of abundant phytochemicals, but intake of the large amount should be taken with care to reduce the risk of toxicity.


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Sources
(1) An experimental evaluation of anticonvulsant activity of Vitex-negundo by Tandon VR1, Gupta RK.(PubMed)
(2) The antiepileptic activity of Vitex agnus castus extract on amygdala kindled seizures in male rats by Saberi M1, Rezvanizadeh A, Bakhtiarian A.(PubMed)
(2) CNS activity of Vitex negundo Linn. in mice by Gupta M1, Mazumder UK, Bhawal SR.(PubMed)

Fennel Optimizes the Digestive Functioning in absorbed Nutrients and Fluids

Fennel may have a therapeutic and enhanced effect in improving the digestive system in absorbed nutrients and fluids from food intake, some scientists suggested.

The result of this efficacy was published online by several respectable institutes, including the University of Illinois at Chicago and Afyon Kocatepe University.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


According to the study, researchers set out criteria and guideline to investigate the effect of fennel in gram-negative bacterium Helicobacter pylori (HP), the microorganisms have been associated with the development of gastritis and peptic ulcer disease to confirm the theory used in traditional medicine fennel to treat a wide range of ailments, including gastrointestinal (GI) disorders such as dyspepsia, gastritis and peptic ulcer disease (PUD), application of methanol extracts of botanicals with a MIC of 50 microg/mL included Achillea millefolium, Foeniculum vulgare (seed), exerted a significant inhibitory effect against all susceptibility of 15 HP strains.


These results suggested that injection of fennel displayed potential in balanced the ratio of microorganisms in the gastrointestinal tract, thus improve the function in absorbed and distributed nutrients to the body and reassured the herbal medicine used in practice for the treatment of numbers symptoms of
digestive disorder.

Furthermore, in animal model with rat induced gastric lesions by injection of ethanol, application of aqueous extracts of Foeniculum vulgare (FVE) showed a strong activity in inhibited the ulcerogenic expression through its antioxidant activities..

In observation of the efficacy of 60 minutes pre-administration of the doses of 75, 150, and 300 mg/kg, with famotidine, histamine H₂ receptor antagonist with function to inhibit stomach acid production, used at the dose of 20 mg/kg, before injection of ethanol, researchers found that

* Pre-treatment of all dose exerted a significant gastric protective effect in reduced injure and damage caused by injection of ethanol.


* Fennel extract demonstrated a therapeutic activity linearly in compared to other doses and control at a dose of 300 mg/kg


* These activities was associated to reduce the malondialdehyde (MDA) levels, a marker in expression of severe levels of oxidative stress.

Additional analysis, also suggested that fennel stimulated gastro-protect effect through its antioxidants and facilitated production of antioxidants found in the body tissues in inhibited the overexpression of free radicals, thus maintaining the ratio of microorganisms in the digestive tract and its functioning.


After, taking into account of other co and confounders, researchers also suggested that the result in part may also attributed to antioxidant in ameliorated lipid peroxidation.

The above differentiation were supported by the joint report lead by the Joint Keio University in the investigation of fennel properties in associated to functional dyspepsia (FD), a functional gastrointestinal disorder characterized by persistent or recurrent postprandial upper abdominal discomfort and epigastric pain.


Truly, Delayed gastric emptying and impaired gastric accommodation was found to play important roles in the development of FD.

Anethole (1-methoxy-4-((E)-propenyl)-benzene), a major component of fennel essential oil, in in rodents exerted a huge effect in improved clonidine-induced delayed gastric emptying without harming to normal gastric emptying in mice, orally.

Also, application of fennel oil plus Anchu-san (a Japanese herbal medicine containing anethole) also demonstrated a important activity in reduced risk of functional dyspepsia (FD) through restoring the delayed gastric emptying.

In other words, anethole processes a gastroprotective efficacy through stimulating gastric accommodation.
Taken together, whole fennel, fennel essential oil and its bioactive compound anethole may be used as secondary application in reduced risk and treatment of digestive disorder. Adding a portion of fennel to your diet may improve the digestive function in absorption nutrients and fluids from the food intake.


However, intake of supplements should be taken with extreme care as an overdose may cause acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders by Mahady GB1, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR.(PubMed)
(2) Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats by Birdane FM1, Cemek M, Birdane YO, Gülçin I, Büyükokuroğlu ME.(PubMed)
(3) Anethole restores delayed gastric emptying and impaired gastric accommodation in rodents by Asano T1, Aida S2, Suemasu S2, Mizushima T3.(PubMed)

Herbal Angelica Processes Anti-diabetes and Immunomodulatory Activities

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The most common symptoms of diabetes are excessive thirst and hunger, frequent urination, unintended weight loss or gain, frequent fatigue, irritability, and gastrointestinal symptoms such as nausea.

Some patients may also experience symptoms of blurred vision and slow wound healing or ulcer.

Prediabetes is caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Therefore, understanding prediabetes is a very important issue for prediabetics, because with proper diets, quit smoking, control alcohol intake, and exercises, prediabetes can be reversed or delayed.

People with a glucose level between 111mg/dl-125 mg/dl are considered pre-diabetics

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Hyperglycemia, a hallmark of diabetes has been found to induce diabetics complications, including neuropathy, nephropathy, and retinopathy).

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a herbal medicine for the prevention and treatment of diabetes, researchers investigated the effects of the decoction HemoHIM on hyperglycemia and the immune response in diabetic mice.

Mice selected for the study were divided into nondiabetic and diabetic mice induced by a single injection of streptozotocin (STZ, 200 mg/kg, i.p.) orally administered HemoHIM (100 mg/kg) once a day for 4 weeks.
Diabetic mice with HemoHIM showed improved hyperglycemia and glucose tolerance as well as elevated plasma insulin levels with the preservation of insulin staining in pancreatic β-cells, compared to the diabetic control group.

Furthermore, HemoHIM treatment restored parameters associated with the onset of diabetes including thymus weight, white blood cells, lymphocyte numbers, and splenic lymphocyte populations (CD4(+) T and CD8(+) T), which were reduced in diabetic mice.

Moreover, HemoHIM also animalized the IFN-γ production associated with innate and adaptive immunity in response to Con A stimulation in facilitating mediated T cell proliferation.

Based on the results, researchers said, "HemoHIM may have potential as a glucose-lowering and immunomodulatory agent by enhancing the immune function of pancreatic β-cells in STZ-induced diabetic mice".

Taken altogether, Herbal Angelica used in the combination with other herbal medicines for the treatment of diabetes, pending to larger sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice by Kim JJ1, Choi J1, Lee MK2, Kang KY3, Paik MJ3, Jo SK4, Jung U4, Park HR4, Yee ST. (PubMed)