By Kyle J. Norton(Draft Article)
Retinitis pigmentosa is a genetic degenerative of eye diseases characteristic of slowly progressive damage of the retina, affecting about 1 in 4,000 people in the United States(1) and about 1in 3500 Canadians.(2).
Epidemiological studies, linking certain herbs, foods and vitamins in delay and alleviation of symptoms of the disease have produced certain success, but large sample size and multi centers studies are necessary to improve the validation of the claims.
A. The herbs
Limitation of research in finding the natural treatment for Retinitis pigmentosa, may be due to its genetically mutative nature.
Bilberry is low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to
the temperate and subarctic regions of the world(3). The herb has been used in folk medicine for its astringent action, an antihistamine effect, and it is also believe to posses anti-microbial as well as anti-diarrheal effects(4), due to its antioxidants effects of delphinidin, cyanidin, petunidin, peonidin, malvidin, etc.(5). According to epidemiological studies. although with limitation, bilberry may be beneficiary in delayed progression and alleviated symptoms of Retinitis pigmentosa due to its effectiveness in protection of vision against many forms of eye diseases.(6)(7)(8)(9). According to 1Johns Hopkins University, in Ninety-six Retinitis pigmentosa (RP) patients with any level of vision completed an anonymous internet survey. bilberry supplement was used in 32% of the correspondents, who were experiencing some impact on vision and physical/emotional well-being(10). In a blue light, a high-energy or short-wavelength visible light induced retinal diseases such as age-related macular degeneration and genetic related retinitis pigmentosa, bilberry extract (B-ext), containing high amounts of polyphenols (anthocyanins, resveratrol, and proanthocyanidins) exhibited its effects in improved the viability of 661 W cells and inhibited the generation of intracellular ROS induced by blue LED light irradiation, probably through inhibited the activation of p38 MAPK and NF-kappaB and caspase-3/7 activation and autophagy(11). Other herbs may also contain similar effects as bilberry such as lingo berry or cowberry(11).
B. The foods
1. The fatty fish and fish oil
Linseed oil or fish oil may have a potential in delay the progression in genetic eye disorder of Retinitis pigmentosa, In retinas of RP rat model, the combination of linseed and fish oil exhibited lower-than-normal levels of ROS DHA may reflect an adaptive, possibly protective, mechanism in the P23H(12). In the University of Ottawa study, Onega 3 fatty acid found abundantly in fish oil showed in improvement of some retinitis pigmentosa outcomes in Clinical preliminary research in this field, further studies are necessary(13). Docosahexaenoic acid (DHA), an other chemical derived from Omega 3 fatty acid, found abundantly in cold water fatty fish, such as salmon, in the study by the Harvard Medical School, showed a positive effect in among patients who were not taking vitamin A prior to entry, those in the DHA + A group had a slower decline in field sensitivity and electroretinogram amplitude than those in the control + A group over the first 2 years(14). Due to the influences of membrane phospholipid fatty acid abnormalities(15), some researchers suggested Fatty acid content alterations in membrane phospholipids of red blood cells of patients with Retinitis pigmentosa may be considered as markers for abnormalities in the lipid metabolism which disturb the retina integrity(16). Unfortunately, according to Johns Hopkins Bloomberg School of Public Health, in the review of the existent data of 394 titles and abstracts and nine ClinicalTrials.gov records and included three RCTs that met eligibility criteria, indicated a no clear evidence for benefit of treatment with DHA for people with RP(13).
2. The coffee
Chlorogenic acid, found in green coffee extract or Coffee, in this prospective, non-comparative, single-arm study, showed a beneficial effect on the peripheral area at the margins of retinal degeneration, and should be considered as an anti-oxidant for the management of retinitis pigmentosa(17)
C. The antioxidants
Antioxidants, may be potential in delay the progression and management of retinitis pigmentosa, according to aster University, when initial signs of vision health deterioration are observed, the appropriate nutritional supplement products may be recommended but only to augment the primary medical treatments(18). Dr. Baumgartner WA and Dr. Baumgartner AM. in one patient study to test a developed and tested a treatment regimen with a range of antioxidants in combination with the off-label use of deprenyl (1 mg/day), a safe antiapoptotic agent, for 140 months indicated a significant improvement as patient's right eye visual field showed 0% decline and left eye 13.3% decline of which defianted to the rate constants for logarithmic decline of visual field measured prior to treatment as visual fields would have decreased by 64% and 70%, respectively by month 140 in the absence of treatment(19).
1. Vitamin A
Vitamin A is a general term of Vitamin A Retinol, retinal, beta-carotene, alpha-carotene, gamma-carotene, and beta-cryptoxanthin best known for its functions for vision health and antioxidant scavenger and essential for growth and differentiation of a number of cells and tissues.
Recommended intakes of vitamin A, according to the Institute of Medicine of the National Academies (formerly National Academy of Sciences) is 600 µg daily as extremely high doses (>9000 mg) can be toxicity as causes of dry, scaly skin, fatigue, nausea, loss of appetite, bone and joint pains, headaches, etc.
Suggestion of the pathology of 11-cis-retinal deficiency caused by gene mutations may result in human retinal diseases that cause blindness, such as Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP)(20) due to involvement in the interaction of light with rhodopsin rather than with free chromophore or bleached rhodopsin(21). In autosomal dominant retinitis pigmentosa patients, vitamin A supplements may be beneficiary for some patients with retinitis pigmentosa, especiallt in patients with autosomal dominant, according to Dr. Roberts L and research team(22). In the regard of Vitamin A's effectiveness in delaying progression of the disease, researchers at the 1Centro di Ricerca in Nutrizione suggested " a lifetime generous supplementation of retinol is advisable, together with a vitamin A-rich diet and/or a dietary supplement (e.g. carrot flour) or pharmacologic supplement of vitamin A. Supply of vitamin A in doses up to 25000 IU (7500 igr/day), even for several years, has so far proved safe from risk of occurrence of liver disease"(23). Although it is controversial, some researchers suggested 15,000 IU of vitamin A palmitate per day may slow the progression, Low vision rehabilitation, long wavelength pass filters, and pedigree counseling remain the mainstay of management(24).
2. Vitamin E
Vitamin E, a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity(2), found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..
Vitamin E supplementation may improve symptoms and prevent the progression of Retinitis pigmentosa as its variant alpha-tocopherol (vitamin E) inhibited proliferation of human RPE in culture without exerting cytotoxic effects.(25). According to the National University of Mexico, in the study of the formula taurine/diltiazem/vitamin E on the progression of visual field loss in retinitis pigmentosa indicated a improving changes in the, slope values with decreasing the rate of visual field loss, likely through a protective action from free radical reactions in affected photoreceptors(26). Unfortunately, the study of supplements of vitamin A or vitamin E alone or in combination in the affect of the course of retinitis pigmentosa, suggested a positive effect in delay and progress of the diseases with 15,000 IU/d of vitamin A but an adverse effect of 400 IU/d of vitamin E on the course of retinitis pigmentosa(27) and vitamin E should be avoided(28).
3. Lutein
Lutien a xanthophyll, belonging to the family of carotenoids, found abundantly in green leafy vegetables such as spinach, kale, yellow carrots, etc., plays an important role in modulation of light energy and protection of retina against damage of free radicals produced by blue light. lutein supplementation may be effective in slowing visual function decline in patients with retinitis pigmentosa receiving vitamin A, according to the Harvard Medical School, dietary intake of Lutein supplementation of 12 mg/d slowed loss of midperipheral visual field on average among nonsmoking adults with retinitis pigmentosa taking vitamin A(29). The randomized double-masked placebo-controlled clinical trial [NCT00029289] conducted by the Johns Hopkins University, suggested that lutein supplementation improves visual field and also might improve visual acuity slightly, although these results should be interpreted cautiously(30). The study at the University of Pennsylvania showed no change no in central vision after 6 months of lutein supplementation, but suggested that a long-term influences on the natural history of these retinal degenerations require further study(31).
Other study also showed the potential effect in the combination application of Lutein and vitamin A in patient of Retinitis pigmentosa, as lutein improved short-term vision improvements in age-related macular degeneration--also occur in RP, especially in blue-eyed individuals; vitamin A may also increase visual field benefits(32).
Taken altogether, excluding vitamin E, even with limitation of data, herbal bilberry, fatty fish and fish oil and antioxidants vitamin A and Lutein may be effective in delay the progression of genetic degenerative eye disease, retinitis pigmentosa, but larger sample size and multi centers studies to improve their validation are necessary. Please make sure you follow the guideline of the Institute of Medicine of the National Academies. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
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References
(1) Retinitis pigmentosa (PubMed)
(2) Retinitis Pigmentosa ~ Overview(The foundation fighting blindness)
(3) Bilberry(Wikipedia)
(4) Bilberry(Herbs2000.com)
(5) Bilberry and its Constituents(MDidea)
(6) Effect of fermented bilberry extracts on visual outcomes in eyes with myopia: a prospective, randomized, placebo-controlled study by Kamiya K1, Kobashi H, Fujiwara K, Ando W, Shimizu K.(PubMed)
(7) Bilberry (Vaccinium myrtillus L.) by Chu W, Cheung SCM, Lau RAW, Benzie IFF.(PubMed)
(8) Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism by Miyake S1, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y.(PubMed)
(9) Protective effect of bilberry (Vaccinium myrtillus L.) extracts on cultured human corneal limbal epithelial cells (HCLEC) by Song J1, Li Y, Ge J, Duan Y, Sze SC, Tong Y, Shaw PC, Ng TB, Tsui KC, Zhuo Y, Zhang KY.(PubMed)
(10) Reported effects of non-traditional treatments and complementary and alternative medicine by retinitis pigmentosa patients by Kiser AK1, Dagnelie G.(PubMed)
(11) Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro by Ogawa K, Kuse Y, Tsuruma K, Kobayashi S, Shimazawa M, Hara H.(PubMed)
(12) Alterations in retinal rod outer segment fatty acids and light-damage susceptibility in P23H rats by Bicknell IR1, Darrow R, Barsalou L, Fliesler SJ, Organisciak DT.(PubMed)
(13) The evidence for efficacy of omega-3 fatty acids in preventing or slowing the progression of retinitis pigmentosa: a systematic review, by Hodge WG1, Barnes D, Schachter HM, Pan YI, Lowcock EC, Zhang L, Sampson M, Morrison A, Tran K, Miguelez M, Lewin G.(PubMed)
(14) Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses by Berson EL1, Rosner B, Sandberg MA, Weigel-DiFranco C, Moser A, Brockhurst RJ, Hayes KC, Johnson CA, Anderson EJ, Gaudio AR, Willett WC, Schaefer EJ.(PubMed)
(15) Red blood cell membrane phosphatidylethanolamine fatty acid content in various forms of retinitis pigmentosa by Schaefer EJ1, Robins SJ, Patton GM, Sandberg MA, Weigel-DiFranco CA, Rosner B, Berson EL.(PubMed)
(16) Evaluation of fatty acids in membrane phospholipids of erythrocytes in retinitis pigmentosa patients by Simonelli F1, Manna C, Romano N, Nunziata G, Voto O, Rinaldi E.(PubMed)
(17) Vitamin A and fish oils for retinitis pigmentosa by Rayapudi S1, Schwartz SG, Wang X, Chavis P.(PubMed)
(18) Antioxidants and vision health: facts and fiction by Grover AK1, Samson SE.(PubMed)
(19) Rationale for an experimental treatment of retinitis pigmentosa: 140-month test of hypothesis with one patient by Baumgartner WA1, Baumgartner AM(PubMed)
(20) Vitamin A derivatives as treatment options for retinal degenerative diseases by Perusek L1, Maeda T.(PubMed)
(21) The dependence of retinal degeneration caused by the rhodopsin P23H mutation on light exposure and vitamin a deprivation by Tam BM1, Qazalbash A, Lee HC, Moritz OL.(PubMed)
(22) Management of a South African family with retinitis pigmentosa-should potential therapy influence translational research protocols? by Roberts L, Rebello G, Ramesar R, Greenberg J.(PubMed)
(23) [Diet and management of degenerative diseases of the retina (retinitis pigmentosa)].[Article in Italian] by Miggiano GA1, Falsini B(PubMed)
(24) Sector retinitis pigmentosa by Van Woerkom C1, Ferrucci S.(PubMed)
(25) Vitamin E inhibits retinal pigment epithelium cell proliferation in vitro by Mojon D1, Boscoboinik D, Haas A, Bohnke M, Azzi A(PubMed)
(26) Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: a 3-year follow-up study by Pasantes-Morales H1, Quiroz H, Quesada O.(PubMed)
(27) A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa by Berson EL1, Rosner B, Sandberg MA, Hayes KC, Nicholson BW, Weigel-DiFranco C, Willett W.(PubMed)
(28) Antioxidants and vision health: facts and fiction by Grover AK1, Samson SE.(PubMed)
(29) Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A by Berson EL1, Rosner B, Sandberg MA, Weigel-DiFranco C, Brockhurst RJ, Hayes KC, Johnson EJ, Anderson EJ, Johnson CA, Gaudio AR, Willett WC, Schaefer EJ.(PubMed)
(30) Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289] by Bahrami H1, Melia M, Dagnelie G.(PubMed)
(31) Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome by Aleman TS1, Duncan JL, Bieber ML, de Castro E, Marks DA, Gardner LM, Steinberg JD, Cideciyan AV, Maguire MG, Jacobson SG.(PubMed)
(32) Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet by Dagnelie G1, Zorge IS, McDonald TM.(PubMed)
Monday, April 7, 2014
Skin aging in Vitamin B5 points of view
Skin aging is one of most visible ageing process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin B5, also known as Pantothenic acid, is a water-soluble vitamin found abundantly in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. The vitamin plays an important role in synthesized and metabolized proteins, carbohydrates, and fats.
According to 1Nutrition Science Solutions LLC, in the study of Hass avocados, containing high amounts of pantothenic acid and other antioxidants, showed a positive effect in supported cardiovascular health and might support weight management and healthy aging(1). A facial lotion containing vitamins B3 and E and provitamin B5, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin in a total of 246 women randomized to treatment, 207 (84%) completed the study(2). Panthenyl triacetate, a Water- and oil-soluble derivative of pantothenic acid (vitamin B5) used combination with Ethyl linoleate (bioactive complex) and given both pre- and post-irradiation, showed to stimulate the repairing enzyme expression caused by skin photo-ageing induced accumulation of oxidized protein(3). Composition of Dead Sea (DS) mud and other ingredients like DS water, zinc oxide, aloe-vera extract, pro-vitamin B5 and vitamin E, exhibited its protective, anti-oxidant and anti-inflammatory properties antagonized biological effects of UVB irradiation in skin(4). Topical application of Dexpanthenol, a supplemental source of pantothetic acid considerably improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures, over 3 to 4 weeks, according to the study by 1Technical University of Munich, Allershausen(5) and enhanced skin barrier repair and stratum corneum hydration, while reducing skin roughness and inflammation(6).
Taken altogether, vitamin B5 may be effective in reduced the onset of skin aging and aginf progression through its antioxidant activity, but further studies are necessary to confirm its claim. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
Natural Remedies for Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and Dementia with step by step instructions through Scientific Studies within 2 Months or your Money back
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(2) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ(PubMed)
(3) A bioactive complex to protect proteins from UV-induced oxidation in human epidermis, by Schweikert K1, Gafner F, Dell'Acqua G.(PubMed)
(4) Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin by Portugal-Cohen M1, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, Neuman R, Kohen R, Milner Y.(PubMed)
(5) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)
(6) Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation by Proksch E1, Nissen HP.(PubMed)
Vitamin B5, also known as Pantothenic acid, is a water-soluble vitamin found abundantly in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. The vitamin plays an important role in synthesized and metabolized proteins, carbohydrates, and fats.
According to 1Nutrition Science Solutions LLC, in the study of Hass avocados, containing high amounts of pantothenic acid and other antioxidants, showed a positive effect in supported cardiovascular health and might support weight management and healthy aging(1). A facial lotion containing vitamins B3 and E and provitamin B5, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin in a total of 246 women randomized to treatment, 207 (84%) completed the study(2). Panthenyl triacetate, a Water- and oil-soluble derivative of pantothenic acid (vitamin B5) used combination with Ethyl linoleate (bioactive complex) and given both pre- and post-irradiation, showed to stimulate the repairing enzyme expression caused by skin photo-ageing induced accumulation of oxidized protein(3). Composition of Dead Sea (DS) mud and other ingredients like DS water, zinc oxide, aloe-vera extract, pro-vitamin B5 and vitamin E, exhibited its protective, anti-oxidant and anti-inflammatory properties antagonized biological effects of UVB irradiation in skin(4). Topical application of Dexpanthenol, a supplemental source of pantothetic acid considerably improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures, over 3 to 4 weeks, according to the study by 1Technical University of Munich, Allershausen(5) and enhanced skin barrier repair and stratum corneum hydration, while reducing skin roughness and inflammation(6).
Taken altogether, vitamin B5 may be effective in reduced the onset of skin aging and aginf progression through its antioxidant activity, but further studies are necessary to confirm its claim. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
Natural Remedies for Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and Dementia with step by step instructions through Scientific Studies within 2 Months or your Money back
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(2) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ(PubMed)
(3) A bioactive complex to protect proteins from UV-induced oxidation in human epidermis, by Schweikert K1, Gafner F, Dell'Acqua G.(PubMed)
(4) Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin by Portugal-Cohen M1, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, Neuman R, Kohen R, Milner Y.(PubMed)
(5) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)
(6) Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation by Proksch E1, Nissen HP.(PubMed)
Sunday, April 6, 2014
Skin aging in Vitamin B3 points of view
Skin aging is one of most visible ageing process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.
Vitamin B3 may be effective to protect against skin-aging through its antioxidant activity(1)(2)(3) such as allowness, wrinkling, red blotchiness and hyperpigmented spots(3a)
In the comparison of the effect on aging skin among a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen, researchers at the showed that the composition significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks with well tolerate adverse effects(4). In facial hyperpigmentation, composition of topical niacinamide and N-acetyl reduced the appearance of irregular pigmentation including hypermelaninization(5) and niacinamide alone enhanced skin lightening, and hyperpigmented lesions(6) through inhibiting melanosome transfer from melanocytes to keratinocytes(7). A daily facial lotion application containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women, 30-60 years of age, for 10 weeks, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin, and positive effects on skin texture, as early as 6 weeks(8). In Global gene expression skin aging process, compounds niacinamide and hexamidine, may effect the skin hydration, barrier, matrix, pigmentation through theirs' antioxidant capacity(9). According to Kinki University School of Medicine, application of composition containing 4% niacinamide in 30 healthy Japanese females who had wrinkles in the eye areas showed to reduced wrinkles in the eye areas through a marked and moderate improvement in 64% of the subjects with a significant difference as compared with the control site(10) and niacinamide aloneexhibited a significant reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing)(11)(12).
Taken altogether, strong evidence suggested that vitamin B3 used alone or combination with other antioxidants may be beneficial in reduced the early onset skin aging and skin aging progression. Overdoses of vitamin B3 may induce symptoms of severe skin flushing combined with dizziness, rapid heartbeat, itching, nausea, vomiting, abdominal pain, etc. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
Natural Remedies for Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and Dementia with step by step instructions through Scientific Studies within 2 Months or your Money back
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) [Anti-aging creams. What really helps?].[Article in German] by Kerscher M1, Buntrock H.(PubMed)
(2) Practical application of cellular bioenergetics to the care of aged skin by Osborne R1, Carver RS, Mullins LA, Finlay DR(PubMed)
(3) Application of genomics to breakthroughs in the cosmetic treatment of skin ageing and discoloration by Osborne R1, Hakozaki T, Laughlin T, Finlay DR.(PubMed)
(3a) Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide by Kawada A1, Konishi N, Oiso N, Kawara S, Date A.([PubMed)
(4) A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen by Fu JJ1, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR.(PubMed)
(5) Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial by Kimball AB1, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL(PubMed)
(6) Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible by Greatens A1, Hakozaki T, Koshoffer A, Epstein H, Schwemberger S, Babcock G, Bissett D, Takiwaki H, Arase S, Wickett RR, Boissy RE(PubMed)
(7) The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer by Hakozaki T1, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE(PubMed)
(8) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ.(PubMed)
(9) Understanding metabolic pathways for skin anti-aging by Osborne R1, Mullins LA, Jarrold BB.(PubMed).
(10) Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide by Kawada A1, Konishi N, Oiso N, Kawara S, Date A.(PubMed)
(11) Niacinamide: A B vitamin that improves aging facial skin appearance by Bissett DL1, Oblong JE, Berge CA(PubMed)
(12) Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin by Bissett DL1, Miyamoto K, Sun P, Li J, Berge CA.(PubMed)
Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.
Vitamin B3 may be effective to protect against skin-aging through its antioxidant activity(1)(2)(3) such as allowness, wrinkling, red blotchiness and hyperpigmented spots(3a)
In the comparison of the effect on aging skin among a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen, researchers at the showed that the composition significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks with well tolerate adverse effects(4). In facial hyperpigmentation, composition of topical niacinamide and N-acetyl reduced the appearance of irregular pigmentation including hypermelaninization(5) and niacinamide alone enhanced skin lightening, and hyperpigmented lesions(6) through inhibiting melanosome transfer from melanocytes to keratinocytes(7). A daily facial lotion application containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women, 30-60 years of age, for 10 weeks, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin, and positive effects on skin texture, as early as 6 weeks(8). In Global gene expression skin aging process, compounds niacinamide and hexamidine, may effect the skin hydration, barrier, matrix, pigmentation through theirs' antioxidant capacity(9). According to Kinki University School of Medicine, application of composition containing 4% niacinamide in 30 healthy Japanese females who had wrinkles in the eye areas showed to reduced wrinkles in the eye areas through a marked and moderate improvement in 64% of the subjects with a significant difference as compared with the control site(10) and niacinamide aloneexhibited a significant reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing)(11)(12).
Taken altogether, strong evidence suggested that vitamin B3 used alone or combination with other antioxidants may be beneficial in reduced the early onset skin aging and skin aging progression. Overdoses of vitamin B3 may induce symptoms of severe skin flushing combined with dizziness, rapid heartbeat, itching, nausea, vomiting, abdominal pain, etc. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) [Anti-aging creams. What really helps?].[Article in German] by Kerscher M1, Buntrock H.(PubMed)
(2) Practical application of cellular bioenergetics to the care of aged skin by Osborne R1, Carver RS, Mullins LA, Finlay DR(PubMed)
(3) Application of genomics to breakthroughs in the cosmetic treatment of skin ageing and discoloration by Osborne R1, Hakozaki T, Laughlin T, Finlay DR.(PubMed)
(3a) Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide by Kawada A1, Konishi N, Oiso N, Kawara S, Date A.([PubMed)
(4) A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen by Fu JJ1, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR.(PubMed)
(5) Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial by Kimball AB1, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL(PubMed)
(6) Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible by Greatens A1, Hakozaki T, Koshoffer A, Epstein H, Schwemberger S, Babcock G, Bissett D, Takiwaki H, Arase S, Wickett RR, Boissy RE(PubMed)
(7) The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer by Hakozaki T1, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE(PubMed)
(8) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ.(PubMed)
(9) Understanding metabolic pathways for skin anti-aging by Osborne R1, Mullins LA, Jarrold BB.(PubMed).
(10) Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide by Kawada A1, Konishi N, Oiso N, Kawara S, Date A.(PubMed)
(11) Niacinamide: A B vitamin that improves aging facial skin appearance by Bissett DL1, Oblong JE, Berge CA(PubMed)
(12) Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin by Bissett DL1, Miyamoto K, Sun P, Li J, Berge CA.(PubMed)
Saturday, April 5, 2014
Skin aging in Vitamin E points of view
Skin aging is one of most visible ageing process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin E, a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity(2), found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..
Epidemiological studies, linking vitamin E in reduced progression of aging have been in conclusive(1)(2)(3)(4).
The effects
According to the Universiti Kebangsaan Malaysia, in stress-induced premature senescence (SIPS) model of human diploid fibroblasts (HDFs), γ-tocotrienol (GTT), a vitamin E variant showed to delay cellular senescence of human diploid fibroblasts through the inhibition of intrinsic mitochondria-mediated pathway which involved the regulation of pro- and anti-apoptotic genes and proteins(5) and prevented cellular aging in human diploid fibroblasts(6), probably through modulating gene expression(7) and protected against oxidative stress-induced cellular ageing by modulating the telomere length possibly via telomerase(8). The molecular mechanism of tocotrienol-rich fraction (TRF) study insisted that the variants protected against H(2)O(2)-induced oxidative stress in human skin fibroblast culture by modulating the expression of COL I and COL III genes with concomitant increase in the rate of total collagen synthesis(9). According to the National University of Malaysia, f alpha-tocopherol (ATF), another variant of vitamin E protected against H(2)O(2)-induced DNA damage and telomere shortening of normal human skin fibroblast cells derived from young and old individual donors(10) and topical administration of alpha-tocopherol (ATF), in medium doses, may provided some degree of photoprotection against UVA(11). Some researchers suggested the potent of vitamins in reduced aging progression is a result of the balance between various skin antioxidants of vitamin E and C, through new delivery systems, in delivering vitamins C and E into the skin simultaneously(12). Other antioxidant in improved skin health, include vitamin E, certain flavonoids, and the carotenoids, β-carotene, lycopene and lutein, may also effective through protection against inflammation, oxidative stress, breakdown of the extracellular matrix(13). In Indian women with facial signs of aging study, the composition of niacinamide, panthenol, and tocopheryl acetate significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin, versus control in 6 weeks(14).
Taken altogether, composition of vitamin E and other antioxidants and its variants may be effective
in reduced early onset of skin aging and inhibited skin aging progression, but large sample size and multi centers studies to improved these validation are necessary. Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.
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References
(1) Evaluation of the photoprotective effect of oral vitamin E supplementation by Werninghaus K1, Meydani M, Bhawan J, Margolis R, Blumberg JB, Gilchrest BA.(PubMed)
(2) Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E) by Eberlein-König B1, Placzek M, Przybilla B(PubMed)
(3) Effects of oral vitamin E and beta-carotene supplementation on ultraviolet radiation-induced oxidative stress in human skin by McArdle F1, Rhodes LE, Parslew RA, Close GL, Jack CI, Friedmann PS, Jackson MJ(PubMed)
(4) Effect of UV exposure and beta-carotene supplementation on delayed-type hypersensitivity response in healthy older men by Herraiz LA1, Hsieh WC, Parker RS, Swanson JE, Bendich A, Roe DA.(PubMed)
(5) Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts by Makpol S1, Abdul Rahim N, Hui CK, Ngah WZ(PubMed)
(6) Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts by Makpol S1, Zainuddin A, Chua KH, Yusof YA, Ngah WZ.(PubMed)
(7) Gamma-tocotrienol modulated gene expression in senescent human diploid fibroblasts as revealed by microarray analysis by Makpol S1, Zainuddin A, Chua KH, Mohd Yusof YA, Ngah WZ.(PubMed)
(8) Gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals by Makpol S1, Abidin AZ, Sairin K, Mazlan M, Top GM, Ngah WZ.(PubMed)
(9) Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction by Makpol S1, Azura Jam F, Anum Mohd Yusof Y, Zurinah Wan Ngah W.(PubMed)
(10) Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals by Makpol S1, Zainuddin A, Rahim NA, Yusof YA, Ngah WZ.(PubMed)
(11) A pilot study of the photoprotective effect of almond phytochemicals in a 3D human skin equivalent by Evans-Johnson JA1, Garlick JA, Johnson EJ, Wang XD, Oliver Chen CY.(PubMed)
(11) Main approaches for delivering antioxidant vitamins through the skin to prevent skin ageing by Gašperlin M1, Gosenca M(PubMed)
(12) The role of phytonutrients in skin health by Evans JA1, Johnson EJ.(PubMed)
(14) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ.(PubMed)
Vitamin E, a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity(2), found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..
Epidemiological studies, linking vitamin E in reduced progression of aging have been in conclusive(1)(2)(3)(4).
The effects
According to the Universiti Kebangsaan Malaysia, in stress-induced premature senescence (SIPS) model of human diploid fibroblasts (HDFs), γ-tocotrienol (GTT), a vitamin E variant showed to delay cellular senescence of human diploid fibroblasts through the inhibition of intrinsic mitochondria-mediated pathway which involved the regulation of pro- and anti-apoptotic genes and proteins(5) and prevented cellular aging in human diploid fibroblasts(6), probably through modulating gene expression(7) and protected against oxidative stress-induced cellular ageing by modulating the telomere length possibly via telomerase(8). The molecular mechanism of tocotrienol-rich fraction (TRF) study insisted that the variants protected against H(2)O(2)-induced oxidative stress in human skin fibroblast culture by modulating the expression of COL I and COL III genes with concomitant increase in the rate of total collagen synthesis(9). According to the National University of Malaysia, f alpha-tocopherol (ATF), another variant of vitamin E protected against H(2)O(2)-induced DNA damage and telomere shortening of normal human skin fibroblast cells derived from young and old individual donors(10) and topical administration of alpha-tocopherol (ATF), in medium doses, may provided some degree of photoprotection against UVA(11). Some researchers suggested the potent of vitamins in reduced aging progression is a result of the balance between various skin antioxidants of vitamin E and C, through new delivery systems, in delivering vitamins C and E into the skin simultaneously(12). Other antioxidant in improved skin health, include vitamin E, certain flavonoids, and the carotenoids, β-carotene, lycopene and lutein, may also effective through protection against inflammation, oxidative stress, breakdown of the extracellular matrix(13). In Indian women with facial signs of aging study, the composition of niacinamide, panthenol, and tocopheryl acetate significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin, versus control in 6 weeks(14).
Taken altogether, composition of vitamin E and other antioxidants and its variants may be effective
in reduced early onset of skin aging and inhibited skin aging progression, but large sample size and multi centers studies to improved these validation are necessary. Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.
Natural Remedies for Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and Dementia with step by step instructions through Scientific Studies within 2 Months or your Money back
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
References
(1) Evaluation of the photoprotective effect of oral vitamin E supplementation by Werninghaus K1, Meydani M, Bhawan J, Margolis R, Blumberg JB, Gilchrest BA.(PubMed)
(2) Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E) by Eberlein-König B1, Placzek M, Przybilla B(PubMed)
(3) Effects of oral vitamin E and beta-carotene supplementation on ultraviolet radiation-induced oxidative stress in human skin by McArdle F1, Rhodes LE, Parslew RA, Close GL, Jack CI, Friedmann PS, Jackson MJ(PubMed)
(4) Effect of UV exposure and beta-carotene supplementation on delayed-type hypersensitivity response in healthy older men by Herraiz LA1, Hsieh WC, Parker RS, Swanson JE, Bendich A, Roe DA.(PubMed)
(5) Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts by Makpol S1, Abdul Rahim N, Hui CK, Ngah WZ(PubMed)
(6) Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts by Makpol S1, Zainuddin A, Chua KH, Yusof YA, Ngah WZ.(PubMed)
(7) Gamma-tocotrienol modulated gene expression in senescent human diploid fibroblasts as revealed by microarray analysis by Makpol S1, Zainuddin A, Chua KH, Mohd Yusof YA, Ngah WZ.(PubMed)
(8) Gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals by Makpol S1, Abidin AZ, Sairin K, Mazlan M, Top GM, Ngah WZ.(PubMed)
(9) Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction by Makpol S1, Azura Jam F, Anum Mohd Yusof Y, Zurinah Wan Ngah W.(PubMed)
(10) Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals by Makpol S1, Zainuddin A, Rahim NA, Yusof YA, Ngah WZ.(PubMed)
(11) A pilot study of the photoprotective effect of almond phytochemicals in a 3D human skin equivalent by Evans-Johnson JA1, Garlick JA, Johnson EJ, Wang XD, Oliver Chen CY.(PubMed)
(11) Main approaches for delivering antioxidant vitamins through the skin to prevent skin ageing by Gašperlin M1, Gosenca M(PubMed)
(12) The role of phytonutrients in skin health by Evans JA1, Johnson EJ.(PubMed)
(14) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ.(PubMed)
Food theray - Celery
Celery is a species of Apium graveolens, belong to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
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1. Celery and atrophic gastritis and gastric cancer progression
Stomach cancer/gastric cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
atrophic gastritis is a process of chronic inflammation of the stomach mucosa.
Apigenin, one of the most common flavonoids, found abundantly in celery, in a joint study from institution in Taiwan, including the Kaohsiung Medical University Hospital, showed effectively decreased atrophic gastritis (atrophic gastritis group) and dysplasia/gastric cancer (gastric cancer group) rates in Mongolian gerbils induced by Helicobacter pylori colonization and Helicobacter pylori(b). Celery seed extract (CSE), in in a dose- and time-dependent manner, exhibited anti-proliferation effect on human gastric cancer BGC-823 cells, through Cell cycle arrest and apoptosis related proteins, such as cyclin A, CDK2, down regulated bcl-2 and up -regulated Bax pathways(c).
Celery seed oil, in benzo[a]pyrene- (BP) induced forestomach cancer in mice, the chemical constituents. 3-n-butyl phthalide and sedanolide showed to reduce tumor incidence from 68% to 30% and 11%, and 67% and 83% in tumor multiplicity, respectively(d). In fact, according to the State University of New York, dietary intake of celery, substantial reductions in risk gastric cancer is associated to its phytochemical such as carotene(e).
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils by Kuo CH1, Weng BC2, Wu CC3, Yang SF4, Wu DC5, Wang YC(PubMed)
(c) Molecular mechanisms of celery seed extract induced apoptosis via s phase cell cycle arrest in the BGC-823 human stomach cancer cell line by Gao LL1, Feng L, Yao ST, Jiao P, Qin SC, Zhang W, Zhang YB, Li FR(PubMed)
(d) Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil by Zheng GQ1, Kenney PM, Zhang J, Lam LK(PubMed)
(e) Diet in the epidemiology of gastric cancer by Graham S1, Haughey B, Marshall J, Brasure J, Zielezny M, Freudenheim J, West D, Nolan J, Wilkinson G.(PubMed)
2. Celery and liver cancer
Liver cancer is defined as a condition of abnormal cell growth in the liver. Commonly, proliferation starts at bile ducts, blood vessels or connective tissue of the liver.
According to the study at Shanghai Jiaotong University School of Medicine, dietary intake high amounts of celery was associated with reduced liver cancer risk(b). Methanolic extract of celery seeds, in Wistar rats study, showed to protect against diethylnitrosoamine (DEN)+2-acetylaminofluorine (AAF)+partial hepatectomy (PH) induced hepatocarcinogenesis in dose dependent manner, through modulation of cell proliferation, metabolism and altered hepatic foci development(c). Perillyl alcohol(d), its essential oils(e) and chemical compound phthalides(f) found in celery seed may be potent in treating liver tumors, with Perillyl alcohol also acting as a chemopreventative agent for other cancers, such as colon, skin, and lung cancer.
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Vegetable-based dietary pattern and liver cancer risk: results from the Shanghai women's and men's health studies by Zhang W1, Xiang YB, Li HL, Yang G, Cai H, Ji BT, Gao YT, Zheng W, Shu XO(PubMed)
(c) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development by Sultana S1, Ahmed S, Jahangir T, Sharma S(PubMed)
(d) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
(e) Influence of certain essential oils on carcinogen-metabolizing enzymes and acid-soluble sulfhydryls in mouse liver by Banerjee S1, Sharma R, Kale RK, Rao AR.(PubMed)
(f) Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil by Zheng GQ1, Kenney PM, Zhang J, Lam LK.(PubMed)
3. Celery and Alzheimer's disease
Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.
L-3-n-butylphthalide (L-NBP), containing in the extract from seeds of Apium graveolens Linn (Chinese celery) on cerebral ischemic, vascular dementia and amyloid-β (Aβ)-induced animal models, showed to inhibit oxidative injury, neuronal apoptosis and glial activation, regulating amyloid-β protein precursor (AβPP) processing and reducing Aβ generation(b), improved cognitive impairment such as learning and memory and reduces amyloid-beta in a transgenic model of Alzheimer's disease, through regulating APP(soluble amyloid precursor protein secretion) processing, and reducing glial activation and oxidative stress(c) and protected neurons against Abeta-induced neurotoxicity via inhibiting tau protein hyperphosphorylation(d).
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice by Peng Y1, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.(PubMed)
(c) L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease by Peng Y1, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA(PubMed)
(d) l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells by Peng Y1, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X.(PubMed)
4. Celery and lung cancer
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.
The study of dietary intake of vegetables and fruit and lung cancer risk in Harbin, Heilongjiang province, northeast China(b) and Tin Corporation (YTC) miners in Yunnan(c), showed a positive effect of intake of celery daily in reduced risk of lung cancer. According to Dr. Belanger JT. research, Perillyl alcohol is a monoterpene isolated from the essential oils of celery seeds, exhibited the effect of inducing apoptosis in tumor cells without affecting normal cells and reverting tumor cells back to a differentiated state in very cancer cells, including lung cancer, through increased mannose-6-phosphate/insulin-like growth factor II receptors, tissue growth factor beta receptors, Bak and decreased ras protein prenylation, ubiquinone synthesis, and induce Phase I and Phase II detoxification systems(d).
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Dietary intake of fruit and vegetable and lung cancer risk: a case-control study in Harbin, northeast China by Galeone C1, Negri E, Pelucchi C, La Vecchia C, Bosetti C, Hu J.(PubMed)
(c) [A cohort study on the relationship between vegetable intake and risks of lung cancer in the Tin Corporation (YTC) miners in Yunnan].[Article in Chinese] by Lu Q1, Yao S, Huang C, Lan Y, Cang S, Qiao Y, Wang R.(PubMed)
(d) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
5. Celery and Conlon Cancer
Colon cancer is relatively very common and slowly growing and progress cancer and in predictable way and is the third most commonly diagnosed cancer in developed countries, including US and Canada.
Luteolin is 3',4',5,7-tetrahydroxyflavone found abundantly in celery showed in regulation of cell cycle progression and apoptosis in the HT-29 human colon cancer cell line, through inhibited CDK2, decreased levels of Cyclin D1 levels and promoted G2/M arrest via certain mechanisms(b)(c). In the study of a total of 336 incident cases of histologically confirmed colorectal cancer (111 colon cancer and 225 rectal cancer in Harbin city, the Harbin Medical College found that increased consumption of green vegetables, including celery, have a strong protective effect against colorectal cancer(d).
According to Dr. Belanger JT, Perillyl alcohol,a monoterpene isolated from the essential oils of celery seeds was active in inducing apoptosis in tumor cells without affecting normal cells and can revert tumor cells back to a differentiated state, including colon cancer cells(e).
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin by Lim do Y1, Jeong Y, Tyner AL, Park JH.(PubMed)
(c) Carotenoids and colon cancer by Slattery ML1, Benson J, Curtin K, Ma KN, Schaeffer D, Potter JD.(PubMed)
(d) Diet and cancer of the colon and rectum: a case-control study in China by Hu JF1, Liu YY, Yu YK, Zhao TZ, Liu SD, Wang QQ.(PubMed)
(e) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
6. Celery and hypertension
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways.
In take of overall vegetable was found to have an Inverse associations to blood pressure (BP), including celery(b). Celery (Apium graveolens) seed extracts, in hypertensive rat study, showed to decreased BP and increased the HR, through its active hydrophobic constitutes(c)
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Relations of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study by Chan Q1, Stamler J, Brown IJ, Daviglus ML, Van Horn L, Dyer AR, Oude Griep LM, Miura K, Ueshima H, Zhao L, Nicholson JK, Holmes E, Elliott P(PubMed)
(c) Antihypertensive effect of celery seed on rat blood pressure in chronic administration by Moghadam MH1, Imenshahidi M, Mohajeri SA.(PubMed)
7. Celery and Oxidative stress
Oxidative stress is the damage caused by imbalance between Reactive oxygen species and the abilities of the body to inhibit them.
Increased consumption of fruits and vegetables containing high levels of phytochemicals showed to be effective in preventing chronic diseases related to oxidative stress in the human body, including celery(b).Flavonoid extracts from celery, according to the Harbin Medical University, in the rat study sreduced the activities of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) and increased content of malondialdehyde (MDA) and activity of glutathione peroxidase (GPx)(c). According to University of Novi Sad, roots and leaves extract of celery also, exhibited its scavenging property of OH* and DPPH* radicals and reduction of LPx intensity in liposomes, through their protective (antioxidant) activity(d). Limonene, a major compound found in celery seed oil, process anti free radical activity, and may be used as natural antioxidants in food applications(e).
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Antioxidant and antiproliferative activities of common vegetables by Chu YF1, Sun J, Wu X, Liu RH.(PubMed)
(c) Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats.
12. Celery and anti microbial effects
According to the Iowa State University, celery juice concentrate (CJ) showed to reduce the pH of CJ before addition to the ham had greater impact on L. monocytogenes growth on does depending manner(b). Its wide version, Apium graveolens L. (wild celery), chemical constistuents sedanenolide, neocnidilide and neophytadiene showed to exhibited antifungal activity against Candida albicans, Candida tropicalis, Candida krusei, Candida guilliermondii, Candida parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, Trichophyton mentagrophytes, T. mentagrophytes var. interdigitale, Trichophyton verrucosum, Microsporum canis, Microsporum gypseum, Epidermophyton floccosum, Aspergillus niger, Aspergillus fumigatus and Aspergillus flavus.(c).
In the testing of the effects of Apium graveolens essential oil' antiulcerogenic and antibacterial activities, researchers at the University of Monastir, found that the essential oil of A. graveolens are strongly inhibitory against Escherichia coli and moderately inhibitory against Pseudomonas aeruginosa and Staphylococcus aureus(d)
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(b) The effect of pH and nitrite concentration on the antimicrobial impact of celery juice concentrate compared with conventional sodium nitrite on Listeria monocytogenes by Horsch AM1, Sebranek JG, Dickson JS, Niebuhr SE, Larson EM, Lavieri NA, Ruther BL, Wilson LA.(PubMed)
(c) Isolation of the volatile fraction from Apium graveolens L. (Apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity by Marongiu B1, Piras A, Porcedda S, Falconieri D, Maxia A, Frau MA, Gonçalves MJ, Cavaleiro C, Salgueiro L.(PubMed)
(d) Antiulcerogenic and antibacterial activities of Apium graveolens essential oil and extract by Baananou S1, Bouftira I, Mahmoud A, Boukef K, Marongiu B, Boughattas NA(PubMed)
14. Celery and anti inflammatory activities
Flavone aglycones and others rich in flavone glycosides found Celery extract, according to the study by the The Ohio State University, Columbus, modulated inflammation by reducing TNF-α and NF-κB(b). The extract of the seed from celery (Apium graviolens) (CSE), in mice study, found to found to possess anti-inflammatory activity, gastro-protective activity, and anti-Helicobacter pylori activity(c). Apiin, a major chemical constituents found in celery, showed to exert its anti-inflammatory activity in-vivo, probably through reduction of iNOS enzyme expression(d), the extracts from extracts from Indian celery seed also exhibited anti inflammatory against osteoarthritis caused by microcrystalline hydroxyapatite (BCP) and pseudo-gout(e)
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(b) Flavone deglycosylation increases their anti-inflammatory activity and absorption by Hostetler G1, Riedl K, Cardenas H, Diosa-Toro M, Arango D, Schwartz S, Doseff AI.(PubMed)(c) A toxicological investigation of a celery seed extract having anti-inflammatory activity by Powanda MC1, Rainsford KD.(PubMed)
(d) An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties by Mencherini T1, Cau A, Bianco G, Della Loggia R, Aquino RP, Autore G.(PubMed).
(e) Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products by Whitehouse MW1, Butters DE.(PubMed)
15.Celery and Weight loss
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
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1. Celery and atrophic gastritis and gastric cancer progression
Stomach cancer/gastric cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
atrophic gastritis is a process of chronic inflammation of the stomach mucosa.
Apigenin, one of the most common flavonoids, found abundantly in celery, in a joint study from institution in Taiwan, including the Kaohsiung Medical University Hospital, showed effectively decreased atrophic gastritis (atrophic gastritis group) and dysplasia/gastric cancer (gastric cancer group) rates in Mongolian gerbils induced by Helicobacter pylori colonization and Helicobacter pylori(b). Celery seed extract (CSE), in in a dose- and time-dependent manner, exhibited anti-proliferation effect on human gastric cancer BGC-823 cells, through Cell cycle arrest and apoptosis related proteins, such as cyclin A, CDK2, down regulated bcl-2 and up -regulated Bax pathways(c).
Celery seed oil, in benzo[a]pyrene- (BP) induced forestomach cancer in mice, the chemical constituents. 3-n-butyl phthalide and sedanolide showed to reduce tumor incidence from 68% to 30% and 11%, and 67% and 83% in tumor multiplicity, respectively(d). In fact, according to the State University of New York, dietary intake of celery, substantial reductions in risk gastric cancer is associated to its phytochemical such as carotene(e).
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils by Kuo CH1, Weng BC2, Wu CC3, Yang SF4, Wu DC5, Wang YC(PubMed)
(c) Molecular mechanisms of celery seed extract induced apoptosis via s phase cell cycle arrest in the BGC-823 human stomach cancer cell line by Gao LL1, Feng L, Yao ST, Jiao P, Qin SC, Zhang W, Zhang YB, Li FR(PubMed)
(d) Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil by Zheng GQ1, Kenney PM, Zhang J, Lam LK(PubMed)
(e) Diet in the epidemiology of gastric cancer by Graham S1, Haughey B, Marshall J, Brasure J, Zielezny M, Freudenheim J, West D, Nolan J, Wilkinson G.(PubMed)
2. Celery and liver cancer
Liver cancer is defined as a condition of abnormal cell growth in the liver. Commonly, proliferation starts at bile ducts, blood vessels or connective tissue of the liver.
According to the study at Shanghai Jiaotong University School of Medicine, dietary intake high amounts of celery was associated with reduced liver cancer risk(b). Methanolic extract of celery seeds, in Wistar rats study, showed to protect against diethylnitrosoamine (DEN)+2-acetylaminofluorine (AAF)+partial hepatectomy (PH) induced hepatocarcinogenesis in dose dependent manner, through modulation of cell proliferation, metabolism and altered hepatic foci development(c). Perillyl alcohol(d), its essential oils(e) and chemical compound phthalides(f) found in celery seed may be potent in treating liver tumors, with Perillyl alcohol also acting as a chemopreventative agent for other cancers, such as colon, skin, and lung cancer.
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Vegetable-based dietary pattern and liver cancer risk: results from the Shanghai women's and men's health studies by Zhang W1, Xiang YB, Li HL, Yang G, Cai H, Ji BT, Gao YT, Zheng W, Shu XO(PubMed)
(c) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development by Sultana S1, Ahmed S, Jahangir T, Sharma S(PubMed)
(d) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
(e) Influence of certain essential oils on carcinogen-metabolizing enzymes and acid-soluble sulfhydryls in mouse liver by Banerjee S1, Sharma R, Kale RK, Rao AR.(PubMed)
(f) Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil by Zheng GQ1, Kenney PM, Zhang J, Lam LK.(PubMed)
3. Celery and Alzheimer's disease
Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.
L-3-n-butylphthalide (L-NBP), containing in the extract from seeds of Apium graveolens Linn (Chinese celery) on cerebral ischemic, vascular dementia and amyloid-β (Aβ)-induced animal models, showed to inhibit oxidative injury, neuronal apoptosis and glial activation, regulating amyloid-β protein precursor (AβPP) processing and reducing Aβ generation(b), improved cognitive impairment such as learning and memory and reduces amyloid-beta in a transgenic model of Alzheimer's disease, through regulating APP(soluble amyloid precursor protein secretion) processing, and reducing glial activation and oxidative stress(c) and protected neurons against Abeta-induced neurotoxicity via inhibiting tau protein hyperphosphorylation(d).
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice by Peng Y1, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.(PubMed)
(c) L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease by Peng Y1, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA(PubMed)
(d) l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells by Peng Y1, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X.(PubMed)
4. Celery and lung cancer
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.
The study of dietary intake of vegetables and fruit and lung cancer risk in Harbin, Heilongjiang province, northeast China(b) and Tin Corporation (YTC) miners in Yunnan(c), showed a positive effect of intake of celery daily in reduced risk of lung cancer. According to Dr. Belanger JT. research, Perillyl alcohol is a monoterpene isolated from the essential oils of celery seeds, exhibited the effect of inducing apoptosis in tumor cells without affecting normal cells and reverting tumor cells back to a differentiated state in very cancer cells, including lung cancer, through increased mannose-6-phosphate/insulin-like growth factor II receptors, tissue growth factor beta receptors, Bak and decreased ras protein prenylation, ubiquinone synthesis, and induce Phase I and Phase II detoxification systems(d).
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Dietary intake of fruit and vegetable and lung cancer risk: a case-control study in Harbin, northeast China by Galeone C1, Negri E, Pelucchi C, La Vecchia C, Bosetti C, Hu J.(PubMed)
(c) [A cohort study on the relationship between vegetable intake and risks of lung cancer in the Tin Corporation (YTC) miners in Yunnan].[Article in Chinese] by Lu Q1, Yao S, Huang C, Lan Y, Cang S, Qiao Y, Wang R.(PubMed)
(d) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
5. Celery and Conlon Cancer
Colon cancer is relatively very common and slowly growing and progress cancer and in predictable way and is the third most commonly diagnosed cancer in developed countries, including US and Canada.
Luteolin is 3',4',5,7-tetrahydroxyflavone found abundantly in celery showed in regulation of cell cycle progression and apoptosis in the HT-29 human colon cancer cell line, through inhibited CDK2, decreased levels of Cyclin D1 levels and promoted G2/M arrest via certain mechanisms(b)(c). In the study of a total of 336 incident cases of histologically confirmed colorectal cancer (111 colon cancer and 225 rectal cancer in Harbin city, the Harbin Medical College found that increased consumption of green vegetables, including celery, have a strong protective effect against colorectal cancer(d).
According to Dr. Belanger JT, Perillyl alcohol,a monoterpene isolated from the essential oils of celery seeds was active in inducing apoptosis in tumor cells without affecting normal cells and can revert tumor cells back to a differentiated state, including colon cancer cells(e).
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin by Lim do Y1, Jeong Y, Tyner AL, Park JH.(PubMed)
(c) Carotenoids and colon cancer by Slattery ML1, Benson J, Curtin K, Ma KN, Schaeffer D, Potter JD.(PubMed)
(d) Diet and cancer of the colon and rectum: a case-control study in China by Hu JF1, Liu YY, Yu YK, Zhao TZ, Liu SD, Wang QQ.(PubMed)
(e) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
6. Celery and hypertension
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways.
In take of overall vegetable was found to have an Inverse associations to blood pressure (BP), including celery(b). Celery (Apium graveolens) seed extracts, in hypertensive rat study, showed to decreased BP and increased the HR, through its active hydrophobic constitutes(c)
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Relations of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study by Chan Q1, Stamler J, Brown IJ, Daviglus ML, Van Horn L, Dyer AR, Oude Griep LM, Miura K, Ueshima H, Zhao L, Nicholson JK, Holmes E, Elliott P(PubMed)
(c) Antihypertensive effect of celery seed on rat blood pressure in chronic administration by Moghadam MH1, Imenshahidi M, Mohajeri SA.(PubMed)
7. Celery and Oxidative stress
Oxidative stress is the damage caused by imbalance between Reactive oxygen species and the abilities of the body to inhibit them.
Increased consumption of fruits and vegetables containing high levels of phytochemicals showed to be effective in preventing chronic diseases related to oxidative stress in the human body, including celery(b).Flavonoid extracts from celery, according to the Harbin Medical University, in the rat study sreduced the activities of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) and increased content of malondialdehyde (MDA) and activity of glutathione peroxidase (GPx)(c). According to University of Novi Sad, roots and leaves extract of celery also, exhibited its scavenging property of OH* and DPPH* radicals and reduction of LPx intensity in liposomes, through their protective (antioxidant) activity(d). Limonene, a major compound found in celery seed oil, process anti free radical activity, and may be used as natural antioxidants in food applications(e).
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Antioxidant and antiproliferative activities of common vegetables by Chu YF1, Sun J, Wu X, Liu RH.(PubMed)
(c) Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats.
Cao J1, Zhang X, Wang Q, Jia L, Zhang Y, Zhao X.(PubMed)
(d) Effect of celery (Apium graveolens) extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride by Popović M1, Kaurinović B, Trivić S, Mimica-Dukić N, Bursać M.(PubMed)
(e) Essential oil composition and antiradical activity of the oil of Iraq plants by Kiralan M1, Bayrak A, Abdulaziz OF, Ozbucak T.(PubMed)
8. Celery and Hepatoprotective effect
Hepatoprotective effect is defined of a protection against harmful of the Liver.
In acetaminophen-fed freshwater fish (Pangasius sutchi) induced liver damage, celery (Apium graveolens) leaves, showed to reverse the severity of liver damage, hepatic lipid, glycogen, ions status and histological alterations through its rich flavonoids(b). According to the Panjab University, in testing of Apium graveolens L. (Apiaceae) and Hygrophila auriculata (K. Schum.) Heine (Syn. Astercantha auriculata Nees, Acanthaceae) used in Indian systems of medicine for the treatment of liver ailments, showed a significant hepatoprotective activity of the methanolic extract of the seeds against paracetamol and thioacetamide intoxication in rats(c). Other, in the study of the composition of Celery, chicory leaves, and barley grains, showed a positive effects in decreasing the elevation of liver enzymes (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) and blood lipids(d).
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Hepatoprotective action of celery (Apium graveolens) leaves in acetaminophen-fed freshwater fish (Pangasius sutchi) by Shivashri C1, Rajarajeshwari T, Rajasekar P.(PubMed)
(c) Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats by Singh A1, Handa SS.(PubMed)
(d) Hepatoprotective effect of feeding celery leaves mixed with chicory leaves and barley grains to hypercholesterolemic rats by Abd El-Mageed NM.(PubMed)
9. Celery and cholesterol
Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place. If you have too much low density lipoprotein LDL that is known as bad cholesterol, overtime cholesterol can build up in your arterial walls causing blockage and leading to heart attack and stroke.
The study of the composition of ethanolic extract of seeds of Apium graveolens L. and its chloroform and aqueous basic fraction in olive oil on induced hyperlipidemic rats inhibited the total cholesterol (TC) triglycerides (TG), low density lipoproteins (LDL) level, and significantly increased high density lipoprotein (HDL) in does depended manner(b). Mountain celery seed essential oils (MC-E)' ether fractionate and 1,1-diphenyl-2-picrylhydrazyl exhibited strong hypolipidemic and free radical scanvenging activities, repectively, according to the Da-Yeh University(c). Other study in the genetically hypercholesterolaemic (RICO) rat model, aqueous celery extract, oral admisnistion for 8 weeks induced a significant reduction in serum total cholesterol (TC) level(d)(e)(f).
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Effect of chloroform and aqueous basic fraction of ethanolic extract from Apium graveolens L. in experimentally-induced hyperlipidemia in ratsm by Iyer D1, Patil UK(PubMed)
(c) Hypolipidemic and antioxidant activity of mountain celery (Cryptotaenia japonica Hassk) seed essential oils by Cheng MC1, Lin LY, Yu TH, Peng RY.(PubMed)
(d) The mechanism underlying the hypocholesterolaemic activity of aqueous celery extract, its butanol and aqueous fractions in genetically hypercholesterolaemic RICO rats by Tsi D1, Tan BK.(PubMed)
(e) Effects of celery extract and 3-N-butylphthalide on lipid levels in genetically hypercholesterolaemic (RICO) rats by Tsi D1, Tan BK.(PubMed)
(f) Effects of aqueous celery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet by Tsi D1, Das NP, Tan BK.(PubMed)
10. Celery and stroke
Besides cancer and heart diseases, stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or it's complications.
Celery may consist a potential in improve outcome of after stroke. According to Chinese Academy of Medical Science & Peking Union Medical College , Dl-3-n-butylphthalide (NBP), isolated from the seeds of celery, used as an anti-hypertensive herbal medicine for treating stroke patients(b) in the randomized, double-blind, double-dummy trial enrolled 573 patients within 48 hours of onset of ischemic stroke in China, indicated a positive outcome at the third month after stroke through both NBP intravenous and oral treatment(c). Other in the study of DL-3-n-Butylphthalide (NBP), a synthetic compound based on L-3-n-Butylphthalide given to after the onset of ischemic stroke in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) induced by the middle cerebral artery occlusion (MCAO, found that pre- and post-treatment significantly lowered neurological deficit scores, reduced infarct volume, and minimized pathological changes in the penumbra area(d).
Chinese Secrets To Fatty Liver And Obesity Reversal
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(b) Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial and Cui LY1, Zhu YC, Gao S, Wang JM, Peng B, Ni J, Zhou LX, He J, Ma XQ.(PubMed)
(e) Essential oil composition and antiradical activity of the oil of Iraq plants by Kiralan M1, Bayrak A, Abdulaziz OF, Ozbucak T.(PubMed)
8. Celery and Hepatoprotective effect
Hepatoprotective effect is defined of a protection against harmful of the Liver.
In acetaminophen-fed freshwater fish (Pangasius sutchi) induced liver damage, celery (Apium graveolens) leaves, showed to reverse the severity of liver damage, hepatic lipid, glycogen, ions status and histological alterations through its rich flavonoids(b). According to the Panjab University, in testing of Apium graveolens L. (Apiaceae) and Hygrophila auriculata (K. Schum.) Heine (Syn. Astercantha auriculata Nees, Acanthaceae) used in Indian systems of medicine for the treatment of liver ailments, showed a significant hepatoprotective activity of the methanolic extract of the seeds against paracetamol and thioacetamide intoxication in rats(c). Other, in the study of the composition of Celery, chicory leaves, and barley grains, showed a positive effects in decreasing the elevation of liver enzymes (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) and blood lipids(d).
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Hepatoprotective action of celery (Apium graveolens) leaves in acetaminophen-fed freshwater fish (Pangasius sutchi) by Shivashri C1, Rajarajeshwari T, Rajasekar P.(PubMed)
(c) Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats by Singh A1, Handa SS.(PubMed)
(d) Hepatoprotective effect of feeding celery leaves mixed with chicory leaves and barley grains to hypercholesterolemic rats by Abd El-Mageed NM.(PubMed)
9. Celery and cholesterol
Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place. If you have too much low density lipoprotein LDL that is known as bad cholesterol, overtime cholesterol can build up in your arterial walls causing blockage and leading to heart attack and stroke.
The study of the composition of ethanolic extract of seeds of Apium graveolens L. and its chloroform and aqueous basic fraction in olive oil on induced hyperlipidemic rats inhibited the total cholesterol (TC) triglycerides (TG), low density lipoproteins (LDL) level, and significantly increased high density lipoprotein (HDL) in does depended manner(b). Mountain celery seed essential oils (MC-E)' ether fractionate and 1,1-diphenyl-2-picrylhydrazyl exhibited strong hypolipidemic and free radical scanvenging activities, repectively, according to the Da-Yeh University(c). Other study in the genetically hypercholesterolaemic (RICO) rat model, aqueous celery extract, oral admisnistion for 8 weeks induced a significant reduction in serum total cholesterol (TC) level(d)(e)(f).
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Effect of chloroform and aqueous basic fraction of ethanolic extract from Apium graveolens L. in experimentally-induced hyperlipidemia in ratsm by Iyer D1, Patil UK(PubMed)
(c) Hypolipidemic and antioxidant activity of mountain celery (Cryptotaenia japonica Hassk) seed essential oils by Cheng MC1, Lin LY, Yu TH, Peng RY.(PubMed)
(d) The mechanism underlying the hypocholesterolaemic activity of aqueous celery extract, its butanol and aqueous fractions in genetically hypercholesterolaemic RICO rats by Tsi D1, Tan BK.(PubMed)
(e) Effects of celery extract and 3-N-butylphthalide on lipid levels in genetically hypercholesterolaemic (RICO) rats by Tsi D1, Tan BK.(PubMed)
(f) Effects of aqueous celery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet by Tsi D1, Das NP, Tan BK.(PubMed)
10. Celery and stroke
Besides cancer and heart diseases, stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or it's complications.
Celery may consist a potential in improve outcome of after stroke. According to Chinese Academy of Medical Science & Peking Union Medical College , Dl-3-n-butylphthalide (NBP), isolated from the seeds of celery, used as an anti-hypertensive herbal medicine for treating stroke patients(b) in the randomized, double-blind, double-dummy trial enrolled 573 patients within 48 hours of onset of ischemic stroke in China, indicated a positive outcome at the third month after stroke through both NBP intravenous and oral treatment(c). Other in the study of DL-3-n-Butylphthalide (NBP), a synthetic compound based on L-3-n-Butylphthalide given to after the onset of ischemic stroke in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) induced by the middle cerebral artery occlusion (MCAO, found that pre- and post-treatment significantly lowered neurological deficit scores, reduced infarct volume, and minimized pathological changes in the penumbra area(d).
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(b) Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial and Cui LY1, Zhu YC, Gao S, Wang JM, Peng B, Ni J, Zhou LX, He J, Ma XQ.(PubMed)
(c) DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment by Zhang L1, Yu WH, Wang YX, Wang C, Zhao F, Qi W, Chan WM, Huang Y, Wai MS, Dong J, Yew DT.(PubMed)
11. Celery and Dementia
Dementia is defined as a condition of gradually serious loss of global cognitive ability, including memory, thinking, language, judgment, behavior, etc. According to statistic, over 24 million people living with some form of dementia worldwide.
3-n-Butylphthalide (NBP), a chemical compound extracted from Chinese celery showed an improvement in spatial learning and memory in the ischemic-rat(b). According to Brigham and Women's Hospital, Harvard Medical School, the extract not only consisted neuroprotective effects on ischemic, vascular dementia, and amyloid-beta (Abeta)-infused animal models, but also reduced total cerebral Abeta plaque deposition and lowered Abeta levels in brain homogenates through enhanced soluble amyloid precursor protein secretion (alphaAPPs), alpha-secretase, and PKCalpha expression in Alzheimer's patients(c) and tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice(d).
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(c) L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease by Peng Y1, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA(PubMed)(d) L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice by Peng Y1, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.(PubMed)
11. Celery and Dementia
Dementia is defined as a condition of gradually serious loss of global cognitive ability, including memory, thinking, language, judgment, behavior, etc. According to statistic, over 24 million people living with some form of dementia worldwide.
3-n-Butylphthalide (NBP), a chemical compound extracted from Chinese celery showed an improvement in spatial learning and memory in the ischemic-rat(b). According to Brigham and Women's Hospital, Harvard Medical School, the extract not only consisted neuroprotective effects on ischemic, vascular dementia, and amyloid-beta (Abeta)-infused animal models, but also reduced total cerebral Abeta plaque deposition and lowered Abeta levels in brain homogenates through enhanced soluble amyloid precursor protein secretion (alphaAPPs), alpha-secretase, and PKCalpha expression in Alzheimer's patients(c) and tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice(d).
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(c) L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease by Peng Y1, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA(PubMed)(d) L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice by Peng Y1, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.(PubMed)
12. Celery and anti microbial effects
According to the Iowa State University, celery juice concentrate (CJ) showed to reduce the pH of CJ before addition to the ham had greater impact on L. monocytogenes growth on does depending manner(b). Its wide version, Apium graveolens L. (wild celery), chemical constistuents sedanenolide, neocnidilide and neophytadiene showed to exhibited antifungal activity against Candida albicans, Candida tropicalis, Candida krusei, Candida guilliermondii, Candida parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, Trichophyton mentagrophytes, T. mentagrophytes var. interdigitale, Trichophyton verrucosum, Microsporum canis, Microsporum gypseum, Epidermophyton floccosum, Aspergillus niger, Aspergillus fumigatus and Aspergillus flavus.(c).
In the testing of the effects of Apium graveolens essential oil' antiulcerogenic and antibacterial activities, researchers at the University of Monastir, found that the essential oil of A. graveolens are strongly inhibitory against Escherichia coli and moderately inhibitory against Pseudomonas aeruginosa and Staphylococcus aureus(d)
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(b) The effect of pH and nitrite concentration on the antimicrobial impact of celery juice concentrate compared with conventional sodium nitrite on Listeria monocytogenes by Horsch AM1, Sebranek JG, Dickson JS, Niebuhr SE, Larson EM, Lavieri NA, Ruther BL, Wilson LA.(PubMed)
(c) Isolation of the volatile fraction from Apium graveolens L. (Apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity by Marongiu B1, Piras A, Porcedda S, Falconieri D, Maxia A, Frau MA, Gonçalves MJ, Cavaleiro C, Salgueiro L.(PubMed)
(d) Antiulcerogenic and antibacterial activities of Apium graveolens essential oil and extract by Baananou S1, Bouftira I, Mahmoud A, Boukef K, Marongiu B, Boughattas NA(PubMed)
14. Celery and anti inflammatory activities
Flavone aglycones and others rich in flavone glycosides found Celery extract, according to the study by the The Ohio State University, Columbus, modulated inflammation by reducing TNF-α and NF-κB(b). The extract of the seed from celery (Apium graviolens) (CSE), in mice study, found to found to possess anti-inflammatory activity, gastro-protective activity, and anti-Helicobacter pylori activity(c). Apiin, a major chemical constituents found in celery, showed to exert its anti-inflammatory activity in-vivo, probably through reduction of iNOS enzyme expression(d), the extracts from extracts from Indian celery seed also exhibited anti inflammatory against osteoarthritis caused by microcrystalline hydroxyapatite (BCP) and pseudo-gout(e)
Natural Remedies for Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and Dementia with step by step instructions through Scientific Studies within 2 Months or your Money back
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)(b) Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis by Zhang L1, Lü L, Chan WM, Huang Y, Wai MS, Yew DT.(PubMed)
(b) Flavone deglycosylation increases their anti-inflammatory activity and absorption by Hostetler G1, Riedl K, Cardenas H, Diosa-Toro M, Arango D, Schwartz S, Doseff AI.(PubMed)(c) A toxicological investigation of a celery seed extract having anti-inflammatory activity by Powanda MC1, Rainsford KD.(PubMed)
(d) An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties by Mencherini T1, Cau A, Bianco G, Della Loggia R, Aquino RP, Autore G.(PubMed).
(e) Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products by Whitehouse MW1, Butters DE.(PubMed)
15.Celery and Weight loss
Friday, April 4, 2014
Skin aging in Vitamin D points of view
Kyle J.Norton Skin aging is one of most visible ageing process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including salmon, mackerel, sardines and tuna. The vitamin plays an important role in modulation of cellular proliferation, apoptosis induction, tumor growth suppression and promotion in absorption of minerals, including calcium, iron, magnesium, phosphate and zinc.
1. Plasma of vitamin D
Levels of 25-hydroxyvitamin D levels [25(OH)D] levels was associated to risk of skin aging as the study at Universitätsklinikum des Saarlandes, showed that UV-radiation exerts both skin aging -promoting and -inhibiting effects on skin aging. Altered mineral homeostasis caused by a high vitamin D activity, exhibited the premature aging that include, besides short lifespan, retarded growth, ectopic calcification, immunological deficiency, osteoporosis, atherosclerosis, hypogonadism, skin and general organ atrophy but laboratory investigations convincingly shoed that vitamin D compounds protect the skin against the hazardous effects of various skin aging-inducing agents, including ultraviolet (UV) radiation(1). Therefore optimal serum concentration are necessary due to its U-shaped risk(2). The Stanford University School of Medicine study indicated that vitamin D deficiency enhanced low scores for specific photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling(3), specially in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3(4).
The effects
According to Treviglio-Caravaggio Hospital, daily supplementation of vitamin D indicated is about 800-1,000 IU/day but may increase up to a maximum dose of 2,000 IU/day in conditions of severe vitamin D deficiency with a concomitant reduced or no sun exposure, reduced dietary intake and reduced calcium absorption(5)(6). Some researchers suggested that intrinsic skin aging may reflects the reduction processes that are common in internal organs, as the reduced production of sex hormones influence skin morphology and functions, skin permeability, wound healing, sebaceous lipogenesis, and the metabolism of skin cells in both sex and Vitamin D administered and antioxidant treatment may be beneficial(7). In postmenopausal health, low levels of vitamin D may induce obesity, malabsorption syndromes, medication use (e.g. anticonvulsants, antiretrovirals), skin aging. According to Universidad de Zaragoza, Increased level of the vitamin through regular sunlight exposure (without sunscreens) for 15 min, 3-4 times a week, in the middle of the day in summer may be beneficial, but supplementation intake of vitamin D2 (ergocalciferol) or vitamin D3 (cholecalciferol) should be monitored depending on the dose used and the presence of concomitant medical conditions such as renal disease(8). Dr Johnson MA at the University of Georgia, insisted " Diminished synthesis of vitamin D in the skin that occurs with aging and poor dietary intake contribute to the high prevalence of poor vitamin D status in older adults"(9). Dr. Heaney RP. suggested that cutaneous vitamin D3 synthesis declines with age, it would require input of an additional 2600 iu/d (65 microg/d) of oral vitamin D3 to ensure that 97.5% of older women have 25(OH)D values at or above desirable levels"(10).
Taken altogether, optimal serum concentration was found to interact in enhancing the reduced production of sex hormones and reducing photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling due to aging. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Natural Remedies for Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and Dementia with step by step instructions through Scientific Studies within 2 Months or your Money back
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
References
(1) Unravelling of hidden secrets: The role of vitamin D in skin aging by Reichrath J.(PubMed)
(2) Vitamin D and aging by Tuohimaa P.(PubMed)
(3) Association of facial skin aging and vitamin D levels in middle-aged white women by Chang AL1, Fu T, Amir O, Tang JY.(PubMed)
(4) Aging decreases the capacity of human skin to produce vitamin D3 by MacLaughlin J, Holick MF.(PubMed)
(5) Vitamin D: role and opportunity to prescribe by Resmini G1, Tarantino U, Iolascon G.(PubMed)
(6) Vitamin D and aging by Gallagher JC.(PubMed)
(7) Hormonal therapy of intrinsic aging by Zouboulis CC1, Makrantonaki E.(PubMed)
(8) EMAS position statement: Vitamin D and postmenopausal health by Pérez-López FR1, Brincat M, Erel CT, Tremollieres F, Gambacciani M, Lambrinoudaki I, Moen MH, Schenck-Gustafsson K, Vujovic S, Rozenberg S, Rees M(PubMed)
(9) Nutrition and aging--practical advice for healthy eating by Johnson MA(PubMed)
(10) Barriers to optimizing vitamin D3 intake for the elderly by Heaney RP.(PubMed)
Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including salmon, mackerel, sardines and tuna. The vitamin plays an important role in modulation of cellular proliferation, apoptosis induction, tumor growth suppression and promotion in absorption of minerals, including calcium, iron, magnesium, phosphate and zinc.
1. Plasma of vitamin D
Levels of 25-hydroxyvitamin D levels [25(OH)D] levels was associated to risk of skin aging as the study at Universitätsklinikum des Saarlandes, showed that UV-radiation exerts both skin aging -promoting and -inhibiting effects on skin aging. Altered mineral homeostasis caused by a high vitamin D activity, exhibited the premature aging that include, besides short lifespan, retarded growth, ectopic calcification, immunological deficiency, osteoporosis, atherosclerosis, hypogonadism, skin and general organ atrophy but laboratory investigations convincingly shoed that vitamin D compounds protect the skin against the hazardous effects of various skin aging-inducing agents, including ultraviolet (UV) radiation(1). Therefore optimal serum concentration are necessary due to its U-shaped risk(2). The Stanford University School of Medicine study indicated that vitamin D deficiency enhanced low scores for specific photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling(3), specially in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3(4).
The effects
According to Treviglio-Caravaggio Hospital, daily supplementation of vitamin D indicated is about 800-1,000 IU/day but may increase up to a maximum dose of 2,000 IU/day in conditions of severe vitamin D deficiency with a concomitant reduced or no sun exposure, reduced dietary intake and reduced calcium absorption(5)(6). Some researchers suggested that intrinsic skin aging may reflects the reduction processes that are common in internal organs, as the reduced production of sex hormones influence skin morphology and functions, skin permeability, wound healing, sebaceous lipogenesis, and the metabolism of skin cells in both sex and Vitamin D administered and antioxidant treatment may be beneficial(7). In postmenopausal health, low levels of vitamin D may induce obesity, malabsorption syndromes, medication use (e.g. anticonvulsants, antiretrovirals), skin aging. According to Universidad de Zaragoza, Increased level of the vitamin through regular sunlight exposure (without sunscreens) for 15 min, 3-4 times a week, in the middle of the day in summer may be beneficial, but supplementation intake of vitamin D2 (ergocalciferol) or vitamin D3 (cholecalciferol) should be monitored depending on the dose used and the presence of concomitant medical conditions such as renal disease(8). Dr Johnson MA at the University of Georgia, insisted " Diminished synthesis of vitamin D in the skin that occurs with aging and poor dietary intake contribute to the high prevalence of poor vitamin D status in older adults"(9). Dr. Heaney RP. suggested that cutaneous vitamin D3 synthesis declines with age, it would require input of an additional 2600 iu/d (65 microg/d) of oral vitamin D3 to ensure that 97.5% of older women have 25(OH)D values at or above desirable levels"(10).
Taken altogether, optimal serum concentration was found to interact in enhancing the reduced production of sex hormones and reducing photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling due to aging. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Natural Remedies for Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and Dementia with step by step instructions through Scientific Studies within 2 Months or your Money back
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
References
(1) Unravelling of hidden secrets: The role of vitamin D in skin aging by Reichrath J.(PubMed)
(2) Vitamin D and aging by Tuohimaa P.(PubMed)
(3) Association of facial skin aging and vitamin D levels in middle-aged white women by Chang AL1, Fu T, Amir O, Tang JY.(PubMed)
(4) Aging decreases the capacity of human skin to produce vitamin D3 by MacLaughlin J, Holick MF.(PubMed)
(5) Vitamin D: role and opportunity to prescribe by Resmini G1, Tarantino U, Iolascon G.(PubMed)
(6) Vitamin D and aging by Gallagher JC.(PubMed)
(7) Hormonal therapy of intrinsic aging by Zouboulis CC1, Makrantonaki E.(PubMed)
(8) EMAS position statement: Vitamin D and postmenopausal health by Pérez-López FR1, Brincat M, Erel CT, Tremollieres F, Gambacciani M, Lambrinoudaki I, Moen MH, Schenck-Gustafsson K, Vujovic S, Rozenberg S, Rees M(PubMed)
(9) Nutrition and aging--practical advice for healthy eating by Johnson MA(PubMed)
(10) Barriers to optimizing vitamin D3 intake for the elderly by Heaney RP.(PubMed)
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