Skin aging in Vitamin B5 points of view

Skin aging is one of most visible ageing process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin,  affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading  injuries damage regulation pathways of skin,  including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin B5, also known as Pantothenic acid, is a water-soluble vitamin found abundantly in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. The vitamin plays an important role in synthesized and metabolized proteins, carbohydrates, and fats.

According to ¹Nutrition Science Solutions LLC, in the study of Hass avocados, containing high amounts of pantothenic acid and other antioxidants, showed a positive effect in supported cardiovascular health and might support weight management and healthy aging(1). A facial lotion containing vitamins B3 and E and provitamin B5, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin in a total of 246 women randomized to treatment, 207 (84%) completed the study(2). Panthenyl triacetate, a Water- and oil-soluble derivative of pantothenic acid (vitamin B5) used combination with Ethyl linoleate (bioactive complex) and given both pre- and post-irradiation, showed to stimulate the repairing enzyme expression caused by skin photo-ageing induced accumulation of oxidized protein(3). Composition of Dead Sea (DS) mud and other ingredients like DS water, zinc oxide, aloe-vera extract, pro-vitamin B5 and vitamin E, exhibited its protective, anti-oxidant and anti-inflammatory properties antagonized biological effects of UVB irradiation in skin(4). Topical application of Dexpanthenol, a supplemental source of pantothetic acid considerably improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures, over 3 to 4 weeks, according to the study by ¹Technical University of Munich, Allershausen(5) and enhanced skin barrier repair and stratum corneum hydration, while reducing skin roughness and inflammation(6).

Taken altogether, vitamin B5 may be effective in reduced the onset of skin aging and aginf progression through its antioxidant activity, but further studies are necessary to confirm its claim. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.

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References
(a) Skin ageing: natural weapons and strategies by Binic I¹, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S¹, Kaur CD.(PubMed)
(1) Hass avocado composition and potential health effects by Dreher ML¹, Davenport AJ.(PubMed)
(2) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR¹, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ(PubMed)
(3) A bioactive complex to protect proteins from UV-induced oxidation in human epidermis, by Schweikert K¹, Gafner F, Dell'Acqua G.(PubMed)
(4) Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin by Portugal-Cohen M¹, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, Neuman R, Kohen R, Milner Y.(PubMed)
(5) Topical use of dexpanthenol in skin disorders by Ebner F¹, Heller A, Rippke F, Tausch I.(PubMed)
(6) Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation by Proksch E¹, Nissen HP.(PubMed)