Monday, January 26, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): The Preventive Metals Binding Proteins

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
B. Antioxidants and Dementia 
B.2. Metals binding proteins 
1. Ceruloplasmin
Ceruloplasmin, the major copper-carrying protein in the blood plays a role in iron metabolism(227). Decreased level of ceruloplasmin impaired ferroportin stability(229)(230)may induce progressive action tremor, and cognitive decline(227), causing the forming of  superoxide anion radicals(231) and iron overload in the brain, liver, pancreas, and other organs(232).

2. Ferritin
Ferritin, the protein produced by almost all living organisms, acts as a component to fight against iron deficiency and iron overload(233)(234). In a soluble and non-toxic form, the protein is transported to the body needs, including organs(236) for enhancement of the immune system in the presence of an infection(237),  proliferation of lymphoid and myeloid cells(235), cancer(238) and prevention of the infectious agent in attempt of binding iron to form free radicals(239) in most cellular oxidation reactions(239).

3. Lactoferrin
Lactoferrin, a multifunctional protein of the transferrin family, is one of the components of the immune system(240) of the body by fighting against foreign invasion of bacteria and virus(241)(242) and lipid oxidation(243) by inhibiting oxidation in a concentration-dependent manner even at concentrations beyond its capacity(244).

4. Metallothionein
Metallothionein, a family of cysteine-rich(24), low molecular weight proteins binds both physiological heavy metals(245) through detoxified fraction of accumulation(245). It also captures harmful superoxide and hydroxyl radicals(246) by binding the metal ions(247)(248) bounded to cysteine(249).

5. Transferrin
Transferrin, a glycoprotein binded iron very tightly but reversibly, enhances the immune system in fighting against infection, inflammation(250) by creating an environment low in free iron(251) that impedes cell oxidation(253)(254), through rapidly evolving sites reverse to bacterial binding in counteract bacterial iron piracy(250). Transferrin deformation and aggregation are found to associate to neurological disorders such as Parkinson's and Alzheimer's disease(252).

6. Hemoglobin
Hemoglobin, the protein molecule in red blood cells enhances the carrying of oxygen from the lungs to the body's tissues and return CO2 from the tissues to the lungs(255)(256). During oxidate stress, the cell membrane is protected by intraerythrocytic hemoglobin from the forming of free radicals(259), probably through regulating NO(258) and auxin homeostasis(257).

7. Myoglobin
Myoglobin is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates. The binding of oxygen by myoglobin(260) through interaction with pathogens establishment of successful infection and survival  is probably through peroxidase activity(261), thus reducing the free radicals damage caused by oxidate stress(261)(262).

8. Etc.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca    

References
(227) http://www.ncbi.nlm.nih.gov/pubmed/10930377
(228) http://www.ncbi.nlm.nih.gov/pubmed/19769463
(229) http://www.ncbi.nlm.nih.gov/pubmed/22634395
(230) http://www.ncbi.nlm.nih.gov/pubmed/16673405
(231) http://www.ncbi.nlm.nih.gov/pubmed/24090962
(232) http://www.ncbi.nlm.nih.gov/pubmed/25280422
(233) http://www.ncbi.nlm.nih.gov/pubmed/24814729
(224) http://www.ncbi.nlm.nih.gov/pubmed/25501153
(225) http://www.ncbi.nlm.nih.gov/pubmed/25511255 
(226) http://www.ncbi.nlm.nih.gov/pubmed/25052430
(227) http://www.ncbi.nlm.nih.gov/pubmed/25498860
(228) http://www.ncbi.nlm.nih.gov/pubmed/25464026
(229) http://www.ncbi.nlm.nih.gov/pubmed/20655381
(230) http://www.ncbi.nlm.nih.gov/pubmed/24921009
(231) http://www.ncbi.nlm.nih.gov/pubmed/6284006
(232) http://www.ncbi.nlm.nih.gov/pubmed/25089372
(233) http://www.ncbi.nlm.nih.gov/pubmed/4014070
(234) http://www.ncbi.nlm.nih.gov/pubmed/6830706
(235) http://www.ncbi.nlm.nih.gov/pubmed/18191543
(236) http://www.ncbi.nlm.nih.gov/pubmed/17459943 
(237) http://www.ncbi.nlm.nih.gov/pubmed/19428486
(238) http://www.ncbi.nlm.nih.gov/pubmed/23891969
(239) http://www.ncbi.nlm.nih.gov/pubmed/22155779
(240) http://www.ncbi.nlm.nih.gov/pubmed/21847071
(241) http://www.ncbi.nlm.nih.gov/pubmed/25282173
(242) http://www.ncbi.nlm.nih.gov/pubmed/15222464
(243) http://www.ncbi.nlm.nih.gov/pubmed/22304665
(244) http://www.ncbi.nlm.nih.gov/pubmed/11052766
(245) http://www.ncbi.nlm.nih.gov/pubmed/25528420
(246) http://www.ncbi.nlm.nih.gov/pubmed/18561335
(247) http://www.ncbi.nlm.nih.gov/pubmed/16872588
(248) http://www.ncbi.nlm.nih.gov/pubmed/1342190
(249) http://www.ncbi.nlm.nih.gov/pubmed/24493013
(250) http://www.ncbi.nlm.nih.gov/pubmed/25504720
(251) http://www.ncbi.nlm.nih.gov/pubmed/12476940
(252) http://www.ncbi.nlm.nih.gov/pubmed/22119572
(253) http://www.ncbi.nlm.nih.gov/pubmed/7298642
(254) http://www.ncbi.nlm.nih.gov/pubmed/7925932
(255) http://www.ncbi.nlm.nih.gov/pubmed/23820271
(256) http://www.ncbi.nlm.nih.gov/pubmed/12683610
(257) http://www.ncbi.nlm.nih.gov/pubmed/24905914
(258) http://www.ncbi.nlm.nih.gov/pubmed/24815022
(259) http://www.ncbi.nlm.nih.gov/pubmed/20003712
(260) http://www.ncbi.nlm.nih.gov/pubmed/15756816
(260) http://www.ncbi.nlm.nih.gov/pubmed/1575681
(261) http://www.ncbi.nlm.nih.gov/pubmed/24885788
(262) http://www.ncbi.nlm.nih.gov/pubmed/24885788

Sunday, January 25, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): The Preventive Antioxidant enzymes

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
B. Antioxidants and Dementia
B.1. Antioxidant enzymes
Antioxidant enzymes, chemical substances found in plants, protect the body from damage of free radicals by terminating the chain reactions through removing free radical intermediates and inhibiting  oxidation reactions.
1. Catalase
Catalase is an enzyme, found in most living organisms exposed to oxygen for action of converse hydrogen peroxide (free radicals)(226) to water and oxygen as a rate of 40 million molecules of hydrogen peroxide to water and oxygen each second, using either an iron or manganese cofactor. The antioxidants showed to protect cells against the toxic effects of hydrogen peroxide in pathogenesis of oxidative stress-related diseases(222) inducted early stages of aggregation of the amyloid peptides(225), including neurodegeneration(224) such as Alzheimer's diseas(223).

2. Glutathione peroxidase
The function of glutathione peroxidase is to protect the organism from oxidative damage and induced neurodegenerative diseases, such as Alzheimer's disease(228) by removing lipid hydroperoxides(227), causes of oxidation of lipid cell membranes. probably through its major cellular peroxide scavenging enzyme(228) and maintaining the oxidative phosphorylation system and protecting mitochondria(229) and protecting oxidative injury and amyloid toxicity of cortical neurons(230).

3. Glutathione reductase
Glutathione reductase, an antioxidant enzyme capable to regenerate Gglutathione (GSH) levels at 24h(233),  and reduced pair of sulfur atoms glutathione to a organosulfur compound form of antioxidant (consisting of three amino acids joined by peptide bonds) may play an important role in prevention of damage of important cellular components induced neurodegenerative diseases such as PD(231)(232), caused by free radicals and peroxides. probably through its antioxidant and anti-inflammatory properties(231)

4. Super oxide dismutase (both Cu-Zn and Mn)
Super oxide dismutase is an important antioxidant and immune defense(224) in nearly all cells exposed to oxygen by converting superoxide into oxygen and hydrogen peroxide depending on the metal cofactor such as both Cu-Zn and Mn(225), probably through the attenuation of superoxide dismutases (SODs) and catalases (CATs)(225) in enhanced and protection of biochemical/molecular/neurobiological  function(226).

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Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
 
References
(222) http://www.ncbi.nlm.nih.gov/pubmed/25152049
(223) http://www.ncbi.nlm.nih.gov/pubmed/24524075
(224) http://www.ncbi.nlm.nih.gov/pubmed/25241122(225) http://www.ncbi.nlm.nih.gov/pubmed/16141213
(226) http://www.ncbi.nlm.nih.gov/pubmed/24887508
(227) http://www.ncbi.nlm.nih.gov/pubmed/10930377
(228) http://www.ncbi.nlm.nih.gov/pubmed/19769463
(229) http://www.ncbi.nlm.nih.gov/pubmed/22634395
(230) http://www.ncbi.nlm.nih.gov/pubmed/16673405
(231) http://www.ncbi.nlm.nih.gov/pubmed/24090962

Saturday, January 24, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system - The Preventive Do's and Do Not's list

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V.  Preventions
A. Do's and Do Not's list
 1. Mediterranean diet
If you are typical American dieter, you are at increased risk for the development of dementia when you get older as the diet is classified as one of the most unhealthy diet in the existence, according to studies. Mediterranean diet, high monounsaturated fatty acids energy intake appeared to be associated with a high protection against cognitive decline and reduced the prevalence of AD in older people(208). Also recent research supports the hypothesis of calorie intake, among other non-genetic factors, in influence of the risk of clinical dementia.(209).

2. Yoga  
Senile dementia is the mental deterioration, i.e, loss of intellectual ability associated with old age. Yoga is believed to have beneficial effects on cognition, probaby through attenuation of emotional intensity and stress reduction. Yoga participation showed to improve the memory performance, and all other psychophysiological parameters, in patient with dementia(3), including intellect, attention, thinking, comprehension and personality, with preservation of normal level of consciousness(210), according to G.J. Patel Ayurved College.

3. Aging of theory of mind
According to Aging of theory of mind, educational level and cognitive processing are two factors influencing the pattern of the aging.Younger and older group with equally high education outperformed the older group with less education in false-belief and faux-pas tasks, with younger group outperformed the other two groups in the cognitive processing tasks, according to Anhui Medical University(211)

3. Moderate alcohol drinking
Moderate alcohol drinking of less than 2 cups for men and 1 cups for women are said to offers possible health benefits(3), but Binge drinking (ie, alcohol exceeding the amount of 5 bottles of beer or a bottle of wine on 1 occasion at least monthly) in midlife is associated with an increased risk of dementia, according to the follow-up, 103 participants had developed dementia(212).

4.  Stop Smoking or never smoke before
Smoking is a risk factor for several life-threatening diseases, but its long-term association with dementia is controversial and somewhat understudied.  According to a total of 5367 people (25.4%), heavy smoking in midlife was associated with a greater than 100% increase in risk of dementia, AD, and VaD more than 2 decades later(213).

5. Drink you tea and coffee
Caffeine in tea and coffee may enhance cognitive function acutely, but its link to dementia is somewhat inconsistent, but most studies support coffee's favorable and protective effects against cognitive decline, dementia or AD. Coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life(214).

6. Eat you fruits and veggies 
Fruits and veggies containing high amounts of antioxidant enhance the immune system in fighting against forming of free radicals cause to damage to the brain cells of that can lead to dementia. Vitamin E and vitamin C supplements in combination were associated with reduced prevalence and incidence of AD, according to The Johns Hopkins University(215).

7. Regular and moderate exercise for elder
 Regular and moderate exercise may attenuate  the cognitive dysfunctioning, but theirs' induced changes in cognition were not correlated with changes in mood/anxiety, probably through some separate neural systems mediation(216).

8.  Avoid nutritional deficiency with balance diet
a. Beyond our believe, an excess of dietary carbohydrates, particularly fructose, alongside a relative deficiency in dietary fats and cholesterol, may lead to the development of Alzheimer's disease(217).
b. For more of Avoid nutritional deficiency with balance diet, please visit(218)

9. Avoid environment risk of dementia
Certain environment toxins produced as a result of industrialization or naturally have been linked to cognitive degenerative diseases. According to University of British Columbia, novel environmental toxins: steryl glycosides, a potential etiological factor for age-related neurodegenerative diseases, showed   signs of mimicked ALS-PDC, including progressive deficits in motor, cognitive, and olfactory functions associated with neuron loss in the spinal cord, nigrostriatal system, cortex, hippocampus, and olfactory bulb in fed mice(219).

10. No illicit drug, please(220)
Illicit drug used may cause nervous system impairment as a result of direct and indirect effects on the integrity and function of nervous system tissue and, potentially, through immune effects, especially, up to 40% risk of nervous system impairment for patients with  HIV-1 infection.

11. Prevent prolonged period of using certain drug
As aging, accumulation of toxins of certain medication used to treat certain diseases, such as antidepressants, sedatives, cardiovascular drugs and anti-anxiety medications may cause increased risk of cognitive dysfunction causes of dementia-like symptoms(221).

12. Etc.
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Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
 
References
(209) http://www.ncbi.nlm.nih.gov/pubmed/18466323
(210) http://www.ncbi.nlm.nih.gov/pubmed/22342535
(211) http://www.ncbi.nlm.nih.gov/pubmed/22408297
(212) http://www.ncbi.nlm.nih.gov/pubmed/22515730
(213) http://www.ncbi.nlm.nih.gov/pubmed/16222166
(214) http://www.ncbi.nlm.nih.gov/pubmed/20182054
(215) http://www.ncbi.nlm.nih.gov/pubmed/14732624
(216) http://www.ncbi.nlm.nih.gov/pubmed/22554780
(217) http://www.ncbi.nlm.nih.gov/pubmed/21402242
(218) http://healthyliving50over.blogspot.ca/2012/04/delay-dementia-causes-of-dementia.html
(219) http://healthyliving50over.blogspot.ca/2012/05/environment-toxin-causes-of-dementia.html
(220) http://healthyliving50over.blogspot.ca/2012/05/substance-abuse-causes-of-dementia.html
(221) http://healthyliving50over.blogspot.ca/2012/05/medication-causes-of-dementia.html

Friday, January 23, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system - The Complications of Dementia

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. The Symptoms and Complications
B. The Complications
 According to physical complications of patients with dementia occurred in ward in the 12 months from April 2007 to March 2008 recorded in Ichinomiya City Hospital, Ichinomiya, the physical complications can be divided into two categories: (i) serious emergencies occurring in the ward with a possible high risk of mortality within a few days (e.g. pneumonia and upper airway obstruction); and (ii) life-threatening complications arising in the ward that required diagnosis and treatment by specialists from other medical departments (e.g. bone fracture and cancer)(202).
1. Pneumonia
 Pneumonia is common among patients with advanced dementia, especially toward the end of life, due to microbial  inffection, according to Beth Israel Deaconess Medical Center(203).

2. Obstructive Sleep Apnea Syndrome (OSAS) 
The prevalence of OSAS increased with aging, occurring in up to 25% of older adults and up to 48% in patients with Alzheimer's disease, showed to induce symptoms of hypoxia, fragmented sleep, daytime sleepiness, cognitive dysfunction, functional decline, and brain damage, due to reduced cerebral blood flow, ischemic brain lesions, microvascular reactivity, white matter lesions, and grey matter loss(204)

3. Bone fracture
Bone mass and dementia in elderly hip fracture patients may be associated to levels of different aluminium concentrations in water supplies in the areas affecting the negative calcium balance of age-related osteoporosis together predispose to senile dementia.(205)

4. Urinary incontinence
 Urinary incontinence is a common problem in dementia. Almost invariably, the person with dementia will develop incontinence as the disease progresses. However, the primary reasons for incontinence are often not because of any significant pathology in the urinary system. Rather, it is due to factors outside the urinary system, including insertion of tube in assisting urinary flow(206)

5. Venous thromboembolism
 Venous thromboembolism (VTE), caused by a blood clot breaking loose and traveling in the blood, in patients with dementia had a high incidence of fatal pulmonary embolism (PE) and fatal bleeding, according to the study of 37988 patients with 1316 (3.5%) having dementia(207).

6. Etc. 
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Use The Revolutionary Findings To Achieve
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References
(202) http://www.ncbi.nlm.nih.gov/pubmed/20377817
(203) http://www.ncbi.nlm.nih.gov/pubmed/20625013
(204) http://www.ncbi.nlm.nih.gov/pubmed/20739254
(205) http://www.ncbi.nlm.nih.gov/pubmed/3239502
(206) http://www.ncbi.nlm.nih.gov/pubmed/16642241
(207) http://www.ncbi.nlm.nih.gov/pubmed/22374336

Thursday, January 22, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system - The Symptoms and Complications of Dementia

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

IV. Symptoms and Complications of Dementia
Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.
A. Symptoms
A.1. Symptoms of Alzheimer's disease 
Alzheimer's disease is a brain disorder, affecting over 1 million people in US alone with well known  symptoms of lack of concentration (56%), tremors (56%), depression (44%), lack of cooperation (36%), and delusions (32%), psychotic symptoms (delusions, hallucinations, and delirium) and tremors, and emotional symptoms (tearfulness and apathy, lack of concentration and appetite change), according to Hospital de Cruces, Plaza de Cruces s/n, Barakaldo in a study of total of 1014 patients(177) and other symptoms of 

1. Increasing forgetfulness(178)
2. Communication difficulty(179)
3. Anxiety(180)
4. Mood and personal change(181)
5. Delay recall(183)
6. Repeat question(183)
7. Memory loss(182)
8 Aberrant motor behavior (184)
9. Sleep problems (184)
10. Eating problems (184) and
11. Agitation/aggression (184)
10. Etc.

A.2. Symptoms of Diminished quality of acetylcholine
If the nerves located in front of the brain perish, diminished quality of acetylcholine, it can cause language difficulty, memory loss, concentration problem and reduce mobile skills because of lacking reaction in muscular activity and refection.
Symptoms of deficiency of acetylcholine include(185)
1. Difficulty remembering names and faces after meeting people
2. Difficulty remembering peoples birthdays and numbers
3. Difficulty remembering lists, directions or instructions
4. Forgetting common facts
5. Trouble understanding spoken or written language
6. Forget where I put things 
7. Slowed and/or confused thinking
8. Difficulty finding the right words before speaking
9. Disorientation
10. Prefer to do things alone than in groups / social withdrawal
11. Rarely feel passionate
12. Feel despair and lack joy
13. Lost some of my creativity / lack imagination
14 Dry mouth
15. Etc.

A.3. Dementia due to long-term alcohol abuse
Dementia is common in patients with alcoholism. Most symptoms of alcohol dementia are also presented in other types of dementia, with a few qualitative differences(186) involved both cortical and subcortical pathology. According to the article, "What's alcohol-related dementia?" Alcohol dementia induced deterioration in intellectual function with memory not being specifically affected, such as disinhibition, loss of planning, and executive functions and a blithe disregard for the consequences of their behaviour,  affecting mostly of women in  the ages between 30 - 70  with the better rates better than for Korsakoff's Psychosis(187).
Other symptoms in deficits are most frequently observed on tasks of visuospatial function, memory(188) and higher-order (executive) tasks(189)

A.4. Multi-infarct dementia
Also known as vascular dementia, is the second most common form of dementia after Alzheimer's disease in older adults, caused by different mechanisms, affecting the vascular lesions in the brain.with major neurovegetative symptoms of depression unaccompanied by depressed mood/anhedonia in patients with clinically-diagnosed Alzheimer's disease (AD) and multi-infarct dementia (MID)(190).
Symptoms include memory deficits(192) such as
1. Confusion
2. Memory problems
3. Wandering Getting lost
and
4. At least one of behavioural or psychological symptom, such as appetite disturbances irritability and anxiety and emotional suppresion(such as laughing inappropriately, crying inappropriately)
(193), and
5. Difficulty following instructions, and 
6. Bladder incontinence
7. Bowel incontinence(191)

A.5. Dementia associated with Parkinson's disease
Parkinson disease (PD) is a disabling, progressive condition cause of cognitive deficits due to the interruption of frontal-subcortical loops that facilitate cognition and that parallel the motor loop, affecting motor function. These include olfactory deficit, sleep problems such as rapid eye movement behaviour disorder, constipation and male erectile dysfunction.(194).
Other symptoms due to to dopamine (DA) deficiency, include, dysexecutive behaviors(196), such as planning, abstract thinking, flexibility and behavioural control and postural disabilities(197) and
1. Constipation
2. Difficulty swallowing
3. Choking, coughing, or drooling
4. Excessive salivation
5. Excessive sweating
6. Loss of bowel and/or bladder control(195)

A.6. Creutzfeldt-Jakob disease (CJD)
People who have eaten contaminated beef in many years, may be infected with Creutzfeldt-Jakob disease (CJD) without even knowing it. Creutzfeldt-Jakob disease is a quickly progressing and fatal disease,  characterized by rapidly progressive dementia. Initially, individuals experience problems with muscular coordination, personality changes, including impaired memory, judgment, and thinking and impaired vision. People with the disease also may experience insomnia, depression, or unusual sensations.(198).

A.7. Subdural hematoma
 Subdural hemorrhages, the accumulation of blood beneath the outer covering of the brain resulted from the rupture of blood vessel may cause an increase in tracranial pressure, leading compression and damage to delicate brain tissue. Acute subdural hematoma has a high mortality rate.
Other symptoms include
1. Intermittent numbness and weakness of extremity(199) and
2. Loss of consciousnes(201)
3. Irritability
4. Seizures
5. Pain
6. Headache
7. Dizziness
8. Disorientation
9. Weakness
10. Weakness or lethargy
11. Nausea or vomiting
12. Loss of appetite
13. Personality changes
14. Confused speech
15. Difficulty with balance or walking
16. Altered breathing patterns
17. Hearing loss or hearing ringing (tinnitus)
18. Blurred Vision
19. Deviated gaze, or abnormal movement of the eyes(200)
20. Etc.

Natural Remedies for Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and  Dementia  with step by step instructions through Scientific Studies  within 2 Months or your Money back

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html

References
(177) http://www.ncbi.nlm.nih.gov/pubmed/20920205
(178) http://www.ncbi.nlm.nih.gov/pubmed/21315756
(179) http://www.ncbi.nlm.nih.gov/pubmed/25356002
(180) http://www.ncbi.nlm.nih.gov/pubmed/16166409
(181) http://www.ncbi.nlm.nih.gov/pubmed/10796526
(182) http://www.ncbi.nlm.nih.gov/pubmed/25481271
(183) http://www.ncbi.nlm.nih.gov/pubmed/22122408
(184) http://www.ncbi.nlm.nih.gov/pubmed/25065098
(185) http://www.ncbi.nlm.nih.gov/pubmed/18849899
(186) http://www.nutritional-healing.com.au/content/articles-content.php?heading=Acetylcholine%20deficiency
(187) http://neurology.health-cares.net/alcohol-related-dementia.php
(188) http://www.ncbi.nlm.nih.gov/pubmed/25119654
(189) http://www.ncbi.nlm.nih.gov/pubmed/23347747
(190) http://www.ncbi.nlm.nih.gov/pubmed/22164676
(191) http://www.rightdiagnosis.com/m/multi_infarct_dementia/symptoms.htm
(192) http://www.ncbi.nlm.nih.gov/pubmed/24685627
(193) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006603/
(194) http://www.ncbi.nlm.nih.gov/pubmed/20642073
(195) http://www.helpguide.org/elder/parkinsons_disease.htm
(196) http://www.ncbi.nlm.nih.gov/pubmed/25511521
(197) http://www.ncbi.nlm.nih.gov/pubmed/25510818
(198) http://www.ninds.nih.gov/disorders/cjd/detail_cjd.htm#186463058
(199) http://www.ncbi.nlm.nih.gov/pubmed/11558288
(200) http://www.nlm.nih.gov/medlineplus/ency/article/000713.htm

Wednesday, January 21, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Tyrosol and Silymarin

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
C. Phytochemicals Against Dementia
C.8. Tyrosol
Tyrosol is a phytochemical compound, a derivative of phenethyl alcohol, belongings to the group of tyrosol esters, found mostly in olive oil. The phytochemical is best known for its antioxidants in protecting the forming of free radicals and lipid oxidation causes of heart disease(383).
 1. Antioxidant effects
 Tyrosol attenuates the elevated cellular concentrations of reactive oxygen species, NO scavenging(386) and lipid peroxidation, against bacterial invasion(386), DNA damage induced by dioxin toxicity(384) and hydrogen peroxide (H2O2)(385) probably through vary antioxidant-dependent mechanisms. Neurologically, tyrosol showed to exhibit its protective effect against dopaminergic neuronal induced degradation(387) and neurotoxicity(388) in vitro model of Parkinson's disease.

2.  Alzheimer Disease

In Alzheimer Disease, tyrosol has shown to protect neuro-cells damage against amyloid-β-Induced toxicity, probably through anti inflammatory pathways(389). In women, the phytochemical also exerted its antioxidative activity(391), in removing harmful compounds from the body; reducing risk of bacterial respiratory tract, intestinal, and genital tract infections(392); suppressing LDL(392) causes of  the development of cardiovascular disease; and preventing oxidation induced diseases and conditions, such as cardiovascular disorders(392), cancer(392), osteoporosis(393)(394), Alzheimer disease(390)(395)(396)(397).


C.9.  Silymarin
Silymarin is a phytochemical in the class of Lignans (phytoestrogens), found abundantly in artichokes, milk thistle, etc.
1. Antioxidants
Silymarin showed to exert the powerful antioxidant activity into protection of cells against arsenical cytotoxicity(399), via reduced lipid hydroperoxide (LHP) formation with no RNS induction; and hepoprotective(400)(401) in ntitubercular and alcohol-induced hepatotoxicity assays in rats(400)

2. Neuroprotective effect
In impaired cognitive and neurochemical function of diabetic patients and streptozotocin induced diabetic rodents, silibinin promoted DNA protection and reduced oxidative stress in a brain specific area, in part via the activation of the HO system(402); In mouse mode with Parkinson's disease(404), treatment of the phytochemical attenuated dopamine levels induced neuro cells damage causes of  apoptosis(403) via educed brain myeloperoxidase activity associated with AD risk(405) and inflammatory signaling cells(404).


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References 
(383) http://www.ncbi.nlm.nih.gov/pubmed/12548315
(384) http://www.ncbi.nlm.nih.gov/pubmed/25496362
(385) http://www.ncbi.nlm.nih.gov/pubmed/25308544
(386) http://www.ncbi.nlm.nih.gov/pubmed/24912728
(387) http://www.ncbi.nlm.nih.gov/pubmed/23790897
(388) http://www.ncbi.nlm.nih.gov/pubmed/20361927
(389) http://www.ncbi.nlm.nih.gov/pubmed/21605049
(390) http://www.ncbi.nlm.nih.gov/pubmed/22634935
(391) http://www.ncbi.nlm.nih.gov/pubmed/12058980
(392) http://www.ncbi.nlm.nih.gov/pubmed/11123850
(393) http://www.ncbi.nlm.nih.gov/pubmed/24975408
(394) http://www.ncbi.nlm.nih.gov/pubmed/25506212
(395) http://www.ncbi.nlm.nih.gov/pubmed/25461244
(396) http://www.ncbi.nlm.nih.gov/pubmed/24192327
(397) http://www.ncbi.nlm.nih.gov/pubmed/23414128
(398) http://www.ncbi.nlm.nih.gov/pubmed/20735377
(399) http://www.ncbi.nlm.nih.gov/pubmed/20637780
(400) http://www.ncbi.nlm.nih.gov/pubmed/24863352
(401) http://www.ncbi.nlm.nih.gov/pubmed/20034535
(402) http://www.ncbi.nlm.nih.gov/pubmed/21970972
(403) http://www.ncbi.nlm.nih.gov/pubmed/24607817
(404) http://www.ncbi.nlm.nih.gov/pubmed/24507644
(405) http://www.ncbi.nlm.nih.gov/pubmed/24045063

Tuesday, January 20, 2015

Most common diseases of 50 plus - Nutrients Requirements for age of 50 and Over

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.


III. Nutrients Requirements for age of 50 and Over For health and the normal functioning of the body, consuming foods and drinks, containing protein and a specific range of vitamins, minerals and trace elements is necessary to provide sources of energy (calories). Especially plant food phytochemicals with various groups of structure include 3000-4000 individual compounds with possession of a number of different properties(175).

 Daily intakes for micro nutrients recommended by the Department of Health DRVs (Dietary Reference Values)(176)A. Nutrient and                 Recommended daily intake for 50+ years 
1. Calcium (mg)                        700
2. Phosphorus (mg)                  550
3. Magnesium (mg)                   270
4. Sodium (mg)                       1600
5. Potassium (mg)                   3500
6. Chloride (mg)                     2500
7. Iron (mg)                               14.8
8. Zinc (mg)                                 9
9. Copper (mg)                            1.2
10. Selenium (ÎĽg)                      60
11. Iodine (ÎĽg)                         140
12. Vitamin A (ÎĽg)                   600
13. Thiamin (mg)                        0.8
14. Riboflavin (mg)                   1.1
15. Niacin (mg)                       12
16. Vitamin B6 (mg)                  1.2
17. Vitamin B12 (ÎĽg)                 1.5
18. Folate (ÎĽg)                      200
19. Vitamin C (mg)                 40
20. Vitamin D* (ÎĽg)                10

B. Estimated Average Requirements (EARs) for energy
Age (years), Estimated energy requirement for males (kcals per day), Estimated energy requirement for females (kcals per day)
51-59                      2550                                                                        1900
60-64                      2380                                                                        1900
65-74                      2330                                                                        1900
75+                        2100                                                                        1810

C. Proteins
Age (years)   Estimated protein requirement for males (kcals per day)   For females
51+                                            53.3                                                    46.5

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Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html

References
(175) http://bmb.oxfordjournals.org/content/56/1/18.full.pdf
(176) http://www.milk.co.uk/page.aspx?intPageID=116