By Kyle J. Norton Health article writer and researcher; Over
10.000 articles and research papers have been written and published on
line, including world wide health, ezine articles, article base,
healthblogs, selfgrowth, best before it's news, the karate GB daily,
etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia,
and this number doubles every five years above that age. Dementia is
the loss of mental ability, severe enough to interfere with people's
every life and Alzheimer's disease is the most common type of dementia
in aging people.
V. Preventions
B. Antioxidants and Dementia
B.2. Metals binding proteins
1. Ceruloplasmin
Ceruloplasmin, the major copper-carrying protein in the blood plays a role in iron metabolism(227). Decreased level of ceruloplasmin impaired ferroportin stability(229)(230)may induce progressive action tremor, and cognitive decline(227), causing the forming of superoxide anion radicals(231) and iron overload in
the brain, liver, pancreas, and other organs(232).
2. Ferritin
Ferritin,
the protein produced by almost all living organisms, acts as a
component to fight against iron deficiency and iron overload(233)(234).
In a
soluble and non-toxic form, the protein is transported to the body
needs,
including organs(236) for enhancement of the immune system in the
presence of an
infection(237), proliferation of lymphoid and myeloid cells(235),
cancer(238) and prevention of the infectious agent in attempt of binding
iron to form free radicals(239) in most cellular oxidation
reactions(239).
3. Lactoferrin
Lactoferrin,
a multifunctional protein of the transferrin family, is one of the
components of the immune system(240) of the body by fighting against foreign
invasion of bacteria and virus(241)(242) and lipid oxidation(243) by inhibiting
oxidation in a concentration-dependent manner even at concentrations
beyond its capacity(244).
4. Metallothionein
Metallothionein, a family of cysteine-rich(24), low molecular weight proteins binds both physiological heavy metals(245) through detoxified fraction of accumulation(245). It also captures harmful superoxide and
hydroxyl radicals(246) by binding the metal ions(247)(248) bounded to
cysteine(249).
5. Transferrin
Transferrin,
a glycoprotein binded iron very tightly but reversibly, enhances
the immune system in fighting against infection, inflammation(250) by
creating an environment low in free iron(251) that impedes cell
oxidation(253)(254), through rapidly evolving sites reverse to bacterial
binding in counteract bacterial iron piracy(250). Transferrin deformation and aggregation are found to associate to neurological disorders such as Parkinson's and Alzheimer's disease(252).
6. Hemoglobin
Hemoglobin, the protein molecule in red blood cells enhances the carrying
of oxygen from the lungs to the body's tissues and return CO2
from the tissues to the lungs(255)(256). During oxidate stress, the
cell membrane is protected by intraerythrocytic hemoglobin from the
forming of free radicals(259), probably through regulating NO(258) and
auxin homeostasis(257).
7. Myoglobin
Myoglobin
is an iron- and oxygen-binding protein found in the muscle tissue of
vertebrates. The binding of oxygen by myoglobin(260) through interaction
with pathogens establishment of successful infection and survival is
probably through peroxidase activity(261), thus
reducing the free radicals damage caused by oxidate stress(261)(262).
8. Etc.
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References
(227) http://www.ncbi.nlm.nih.gov/pubmed/10930377
(228) http://www.ncbi.nlm.nih.gov/pubmed/19769463
(229) http://www.ncbi.nlm.nih.gov/pubmed/22634395
(230) http://www.ncbi.nlm.nih.gov/pubmed/16673405
(231) http://www.ncbi.nlm.nih.gov/pubmed/24090962
(232) http://www.ncbi.nlm.nih.gov/pubmed/25280422
(233) http://www.ncbi.nlm.nih.gov/pubmed/24814729
(224) http://www.ncbi.nlm.nih.gov/pubmed/25501153
(225) http://www.ncbi.nlm.nih.gov/pubmed/25511255
(226) http://www.ncbi.nlm.nih.gov/pubmed/25052430
(227) http://www.ncbi.nlm.nih.gov/pubmed/25498860
(228) http://www.ncbi.nlm.nih.gov/pubmed/25464026
(229) http://www.ncbi.nlm.nih.gov/pubmed/20655381
(230) http://www.ncbi.nlm.nih.gov/pubmed/24921009
(231) http://www.ncbi.nlm.nih.gov/pubmed/6284006
(232) http://www.ncbi.nlm.nih.gov/pubmed/25089372
(233) http://www.ncbi.nlm.nih.gov/pubmed/4014070
(234) http://www.ncbi.nlm.nih.gov/pubmed/6830706
(235) http://www.ncbi.nlm.nih.gov/pubmed/18191543
(236) http://www.ncbi.nlm.nih.gov/pubmed/17459943
(237) http://www.ncbi.nlm.nih.gov/pubmed/19428486
(238) http://www.ncbi.nlm.nih.gov/pubmed/23891969
(239) http://www.ncbi.nlm.nih.gov/pubmed/22155779
(240) http://www.ncbi.nlm.nih.gov/pubmed/21847071
(241) http://www.ncbi.nlm.nih.gov/pubmed/25282173
(242) http://www.ncbi.nlm.nih.gov/pubmed/15222464
(243) http://www.ncbi.nlm.nih.gov/pubmed/22304665
(244) http://www.ncbi.nlm.nih.gov/pubmed/11052766
(245) http://www.ncbi.nlm.nih.gov/pubmed/25528420
(246) http://www.ncbi.nlm.nih.gov/pubmed/18561335
(247) http://www.ncbi.nlm.nih.gov/pubmed/16872588
(248) http://www.ncbi.nlm.nih.gov/pubmed/1342190
(249) http://www.ncbi.nlm.nih.gov/pubmed/24493013
(250) http://www.ncbi.nlm.nih.gov/pubmed/25504720
(251) http://www.ncbi.nlm.nih.gov/pubmed/12476940
(252) http://www.ncbi.nlm.nih.gov/pubmed/22119572
(253) http://www.ncbi.nlm.nih.gov/pubmed/7298642
(254) http://www.ncbi.nlm.nih.gov/pubmed/7925932
(255) http://www.ncbi.nlm.nih.gov/pubmed/23820271
(256) http://www.ncbi.nlm.nih.gov/pubmed/12683610
(257) http://www.ncbi.nlm.nih.gov/pubmed/24905914
(258) http://www.ncbi.nlm.nih.gov/pubmed/24815022
(259) http://www.ncbi.nlm.nih.gov/pubmed/20003712
(260) http://www.ncbi.nlm.nih.gov/pubmed/15756816
(260) http://www.ncbi.nlm.nih.gov/pubmed/1575681
(261) http://www.ncbi.nlm.nih.gov/pubmed/24885788
(262) http://www.ncbi.nlm.nih.gov/pubmed/24885788
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