Medical Advisor Journals

Wednesday, February 3, 2016

The Tomato, Sunflower Seed and Orange Juice for Reduced Risk and Treatment of Darier's disease (DAR)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for reduced risk and treatment of Darier's disease (DAR)

Yield: 2 serving (about 8 ounce each)
1 1/2 cups tomato
1/4 cup sunflower seed
1 cup organic orange juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Bowen's disease (BD) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Darier disease is a skin condition characterized by wart-like blemishes on the body due genetic mutation of an autosomal dominant disorder induced immunologic functions aggression to its own tissues(4). The most common sites for blemishes are the scalp, forehead, upper arms, chest, back, knees, elbows, and behind the ear(1), affecting affects both men and women

It is hard to believe that some ingredients ignored by the pharmaceutical companies for treatment of Darier's disease (DAR) is now believe to be effectively in form of natural sources. Tomatoes(2), Sunflower seed, may be next generation of potential ingredients in induced the occurrence of skin disorder caused by genetic mutation of an autosomal dominant, namely Darier's disease (DAR) but also is used in treatment of people with the disorder, recent studies of renowned institution suggested.

Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purposeand often in green house. Its derivative retinoids, a class of chemical compounds found abundantly in tomato may be used for treatment of due to its effectiveness in decreased number of desmosomes and other cellular attachments and conspicuous microvillous changes of cell surface in separated basal cells up to 5 months(2).

In a study of a total of 5 patients with Darier's disease treated with systemic retinoid therapy, showed to decrease the number of white blood cell and T-cells, normalized cell production in stimulated production of T cell, and decreased the lymphocyte responses to cell division causes of Darier's disease(2).

Dr. Günther S., said, "....68 patients suffering from palmar/plantar hyperkeratoses of different etiology, small doses of vitamin A acid (retinoic acid) topically applied, produced a striking improvement in hypertrophic lichen planus of palms or soles"(6) and in the concerns of the use of high dosage of vitamin A and retinoids, for treatment of Darier's disease, he also said, "The use of vitamin A is limited by its toxicity, but vitamin A acid being less toxic could be an important therapeutic advance in follicular keratoses"(5).

Sunflower is a genus of Helianthus, belongings to the family Asteraceae andnative to the Americas. It seeds are usually classified by the difference of their husks and considered as healthy snack in many cultures. It is one of most healthy foods containing highest amount vitamin E in comparison to other food sources with potential use in prevention and treatment of Darier's disease (DAR) according to Dr. Ayres S(7).
According to the study of synergism of vitamins A and E with dermatologic applications, in animal model, adding vitamin E to the diet restored the vitamin A serum level to normal effectively control three dermatologic conditions involving a defect in keratinization, namely, keratosis follicularis (Darier's disease), pityriasis rubra pilaris, and acne vulgaris(8).

Orange, a species of Citrus Sinensis, belongings to the family Rutaceae and native to the Southeast Asia is round citrus fruits with finely-textured skins, orange in color and one of most popular fruits in the world. Its vitamin C derivative, ascorbic acid has been found effectively for prevention and treatment of Darier's disease(9)in patient ultraviolet exposure to the onset of Darier's disease(10).

Rich sources of vitamin A, E and C found in tomato, sunflower seed and orange processed a potential benefit for reduced risk and treatment of Darier's disease (DAR). The smoothie containing these ingredients in high amount should also mimic the similar effects in chronic use.
People at higher risk of Darier's disease (DAR) due to genetic mutation causes of immune disorder should drink at least one serving daily and people with the disease should drink as much as they can, depending to the toleration of digestive system.

References
(1) Darier disease: A fold (intertriginous) dermatosis by Engin B1, Kutlubay Z2, Erkan E2, Tüzün Y2.(PubMed)
(2) Treatment of Darier's disease with an oral aromatic retinoid (Ro 10-9359): a clinical and light and electron microscopic study by Lauharanta J, Niemi KM, Lassus A.(PubMed)
(3) Cell-mediated immunity in Darier's disease: effect of systemic retinoid therapy by Soppi AM, Soppi E, Eskola J, Jansén CT.(PubMed)
(4) Darier's disease: a partially immunodeficient state by Jegasothy BV, Humeniuk JM.(PubMed)
(5) Vitamin A acid in Darier's disease by Günther S.(PubMed)
(6) [Therapeutic effect of vitamin A acid (retinoic acid) in various forms of palmar/plantar hyperkeratoses: experimental studies on 68 patients].[Article in German] by Günther S.(PubMed)
(7) Darier's disease with salivary gland obstruction: synergistic therapy with vitamins A and E suggested by S Ayres(PMC)
(8) Synergism of vitamins A and E with dermatologic applications by Ayres S Jr, Mihan R, Scribner MD.(PubMed)
(9) Induction of Darier's disease by repeated irradiation by ultraviolet B; protection by sunscreen and topicalascorbic acid by Heo EP1, Park SH, Yoon TJ, Kim TH(PubMed)
(10) Successful treatment of combination therapy with tacalcitol lotion associated with sunscreen for localizedDarier's disease by Abe M1, Yasuda M, Yokoyama Y, Ishikawa O.(PubMed)

Most Common Diseases of elder: Chronic obstructive pulmonary disease (COPD) (Respiratory Disease):Treatment In conventional medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease
Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
Chronic obstructive pulmonary disease (COPD))is the third leading cause of death in the United State.

Types of Chronic obstructive pulmonary disease (COPD)

1. Emphysema, a type of Chronic obstructive pulmonary disease (COPD), is defined as a long term and progressive condition cause of shortness of breath but depending to the stage of lung function as a result of damage to tissues of the air sacs (alveoli) in the lungs. In the study of 63 patients with stable COPD (spirometric GOLD stages 2–4) and 17 age- and comorbidity-matched controls, researchers found that in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-beta1 in serum. The stage-dependent association with lung function supports the hypothesis that these platelet mediators may play a role in the pathogenesis of COPD(1). In some cases, but rarely, Emphysema is caused by Alpha-1 antitrypsin deficiency emphysema.

2. Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi cause of the increased production of mucus in the lung of that leading to difficult breathing.

The Treatment

In conventional medicine perspective
F1.1. Therapies
1. Incentive spirometry
In the study of a total of 27 consecutive patients (mean age, 68.4 +/- 7.9 years; 26 males) admitted for COPD exacerbations, found that the use of IS appears to improve arterial blood gases and health-related quality of life in patients with COPD exacerbations, although it does not alter pulmonary function parameters(36).

2. Oxygen therapy
Majority of patients in Oxygen therapy have chronic obstructive pulmonary disease (COPD). The multicenter Nocturnal Oxygen Therapy Trial and the smaller Medical Research Council study identified LTOT as an intervention that improved survival in patients with COPD or chronic respiratory failure, approximately doubling survival at 19 months in patients who were adherent to oxygen(37).

3. Bronchodilators
The aim of Bronchodilators is to decrease the resistance in the respiratory airway and increase airflow to the lungs
a. Short-acting bronchodilators
In the study to clarify the additive efficacy of short-acting β(2)-agonists (SABA) or muscarinic antagonists (SAMA) on dynamic hyperinflation and exercise tolerance in patients with chronic obstructive pulmonary disease (COPD) who had been treated with long-acting bronchodilators, showed that he additive efficacy of the two drugs was analyzed. Inhalation of SABA and SAMA improved airflow limitation and dynamic hyperinflation in stable COPD patients who had been treated with LAMA. Inhalation of SABA decreased respiratory resistance and the difference in respiratory resistance at 5 Hz and 20 Hz. On the whole, the additive efficacy of SABA on airflow limitation and dynamic hyperinflation was superior to that of SAMA(38).

b. Long-acting bronchodilators
In an overview of the clinical studies evaluating the safety and efficacy of inhaled aclidinium bromide, a novel long-acting anticholinergic bronchodilator, for the treatment of COPD, showed that clidinium bromide has effects on relevant COPD outcome measures, including level of FEV(1), similar to other long-acting bronchodilators, and therefore seems to have the potential for a significant role in the future management of moderate to severe COPD(35).

c. Side effects of Bronchodilators medicine are not limit to headache, Nervousness, Trembling and shaking, Etc., depending to types of medicine.

4. Phosphodiesterase-4 (PDE4) inhibitors
a. Phosphodiesterases (PDE) are a family of enzymes responsible for the metabolism of the intracellular second messengers cyclic AMP and cyclic GMP. According to the study by GKT School of Biomedical Science, King’s College London, Targeting PDE with selective inhibitors may offer novel therapeutic strategies in the treatment of various conditions, and in the context of respiratory disease these include asthma and chronic obstructive pulmonary disease (COPD)(39). Other study indicated that While there is a wide distribution of these enzymes throughout the body, it is of interest that inflammatory cells thought to participate in the pathogenesis of inflammatory diseases including asthma and chronic obstructive pulmonary disease (COPD), preferentially express PDE4(40).

b. Side effects are not limit to Nausea, Emesis, and related general intestinal problems.

5. Corticosteroids are most frequent used sontrollers in preventing inflammaory airways in asthma patients and COPD.
a. Inhaled corticosteroids
According to the study by University of Nevada School of Medicine, in the review of review is to compare and contrast the newer inhaled corticosteroid (ICS) ciclesonide with older ICSs, showed that once-daily administration of ICSs is generally not as effective as twice-daily. Continuous administration of ICSs does not change the natural history of asthma in either children or adults. Long-term administration of medium dose ICSs does not increase the risk of cataracts or osteopenia in children and young adults(41). Others in the study of Dry powder inhaler (DPI) devices to assess the proportion of patients with asthma or chronic obstructive pulmonary disease (COPD) with significant bronchoobstruction who do not have inspiratory flows necessary for the adequate use of dry powder inhaler (DPI) devices Diskus and Turbuhaler. showed that significant proportion of patients with asthma or COPD with significant bronchoobstruction do not exhibit satisfactory inspiratory flows for the use of dry powder inhaler (DPI) devices (Diskus < Turbuhaler)(42).

b. Oral or intravenous corticosteroids
In the study of 47 patients, 30 females, 17 male, 24 received oral prednisolone and 23 received IV hydrocortisone. At baseline the oral and IV groups were similar (mean, SD) in age (38.3, 12.8 vs 37.3, 12.9, P=0.80) and initial percent predicted (PP) PEF (61, 16.7 vs 69, 13.0, P=0.11). After 72 h both groups had similar improvements in PEF (27%, 26 vs 27%, 19, P=0.96), researchers at the Department of Respiratory and Sleep Disorders Medicine, Western Hospital, found that Corticosteroids administered orally and IV had similar efficacy in the treatment of adults hospitalised with acute asthma(43).

c. Side effects
a.1. psychiatric side effects include mania, depression and mood disturbances within the first two weeks of corticosteroid therapy(44).
2. Short side effects include cutaneous effects, electrolyte abnormalities, hypertension, hyperglycemia, pancreatitis, hematologic, immunologic, and neuropsychologic effects. and Long-term corticosteroid use may be associated with more serious sequel, including osteoporosis, aseptic joint necrosis, adrenal insufficiency, gastrointestinal, hepatic, and ophthalmologic effects, hyperlipidemia, growth suppression, and possible congenital malformations(45).

6. Other medication
6.1. Expectorants
a. Expectorants is the types of medicine used to assist the clearance of mucus from the airways, lungs, bronchi, and trachea. In the study to to determine if treatment with mucolytics reduces the frequency of exacerbations, days of disability, or both, in participants with chronic bronchitis or chronic obstructive pulmonary disease, or both.Secondary objectives: to determine if mucolytics lead to an improvement in lung function or quality of life and to determine the frequency of adverse effects associated with mucolytics, showed that in participants with chronic bronchitis or COPD, treatment with a mucolytic may produce a small reduction in acute exacerbations, but may have little or no effect on the overall quality of life. The effects on exacerbations shown in early trials were larger than those found in the more recent studies(46).Others in the study of group 1 ascoril (10 ml tid), group 2 salbutamol (200 mcg two inhalations tid) plus bromhexin (8 mg tid) for 10 days.indicated that ascoril is most efficacious and safe for the treatment of mild or moderately severe COPD and elimination of its exacerbation. The early prescription of this therapy permits to avoid hospitalization and expensive therapy(47).
b. Side effects are not limit to Nausea, Gastrointestinal Distress, Sleep Complications,Drowsiness, Etc.

6.2. Methylxanthines
a. Methylxanthines represent a unique class of drugs for the treatment of asthma. At lower serum concentrations, theophylline is a weak bronchodilator but retains its capacity as an immunomodulator, anti-inflammatory, and bronchoprotective drug(48). In the study to evaluate the addition of methylxanthines to standard treatments in patients presenting with acute exacerbations of chronic obstructive pulmonary disease (COPD), researchers at the indicated that the available data do not support the use of methylxanthines for the treatment of exacerbations of chronic obstructive pulmonary disease. Potential benefits of methylxanthines for lung function and symptoms were generally not confirmed at standard levels of significance(49).
b, Side effects are not limit to nausea and vomiting, and non-significant increases in tremor, palpitations, and arrhythmias, etc.

F.1.2. Surgery
Surgeries may be the only options for the patient with end-stage COPD, and suffering severe symptoms
1. Lung volume reduction surgery
In the study to to evaluate whether favorable short-term results in term of functional outcome and survival following lung volume reduction surgery persist for longer periods, showed that LVRS can lead to a very long survival (10 years or more) in a small subgroup of patients, with improvement of pulmonary functional data. Some preoperative data (upper lobe distribution of emphysema and pulmonary arterial pressure) appear to predict survival. Lung transplantation can be offered to these patients, showing a trend to improved life expectancy(50).

2. Bullectomy
Bullectomy is the surgical removal of a bullae (greater than 1 cm) which is an air pocket in the lung with an aim to help COPD patients breathe better. A bullectomy may be considered for giant bullae, defined by a volume greater than a third of a hemithorax(51).

3. Lung Transplantation
Patients who are less than 65 years old with end-stage COPD but suffering severe symptoms with no other significant disease may be considered for lung transplant. It offers the greatest functional benefits but also involves considerable risks(51)

According to the study Washington University, St Louis, Missouri, unfortunately, most emphysema patients are poor candidates for any surgical intervention. A meticulous selection process is favoured in which indications and contraindications are considered and the best solution is devised for each patient. Patients with giant bullae filling half the thoracic volume and compressing relatively normal adjacent parenchyma are offered bullectomy; those with hyperinflation, heterogeneous distribution of destruction, forced expiratory volume in 1 second (FEV(1)) >20%, and a normal carbon dioxide tension (PCO(2)) are offered LVRS; and patients with diffuse disease, lower FEV(1), hypercapnia, and associated pulmonary hypertension are directed towards transplantation. Using these criteria, few patients are serious candidates for surgical procedures. Combinations of LVRS and lung transplantation, either simultaneously or sequentially, are possible but rarely necessary(52).

Tuesday, February 2, 2016

The Curable and delicious smoothie of Green Tea, Avocado and Grape for Reduced Risk and Treatment of Contact Dermatitis

Kyle J. Norton(Scholar, Master of Nutrients) All right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The fabulous and tasty smoothie with the power to reduce risk and treatment of stroke through clinical trial, research and studies is a must know to everyone by Kyle J. Norton.

The smoothie for people with high risk of contact dermatitis
Yield: 2 servings (about 8 ounces each)
1 cup grape
1/2 cup avocado
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Contact dermatitis is an immune reaction induced red, itchy rash against substance that comes into contact with your skin. Green tea extracts used for treatment of inflammation, aging, and cardiometabolic effects may also consisted a therapeutic values in relief the symptoms of allergic contact dermatitis(1).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects,
green tea now has been cultivated all over the world in suitable climate. Its extracts consisted anti inflammation, aging, and cardiometabolic effects may also consisted a therapeutic values in relief the symptoms of allergic contact dermatitis(1).

The University Hospitals Case Medical Center Clevelandstudy also suggested that chronic topical application of green tea also exhibited the protection against detrimental effects of UV on cutaneous immunity(2) and DNA damage that formed after UV radiation(3).

Avocados are a commercially valuable fruit, cultivated in tropical climates throughout the world. The green-skinned, pear-shaped fruit ripens after harvesting and native to the Caribbean, Mexico, South America and Central America, belonging to the flowering plant family Lauraceae. According to the Universidade Federal do Paraná, topical avocado reduced secretion of PGE(2) in 12-O-tetradecanoylphorbol-13-acetate (TPA)(a potent tumor promoter )-induced keratinocyte( the outermost layer of the skin)(4).

Application of Polyhydroxylated fatty alcohols derived from avocado, according to Polyol Biotech Ltd, Granot Initiative Center, exert UVB protective effect through increasing cell viability, decreasing the secretion of IL-6 and PGE(2), and enhancing DNA repair(5).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape wine, nuts, peanuts, etc. According to the joint study lead by the Chonnam National University Medical School, ethanol extract of peanut sprouts (EPS) inhibited protective effect against contact dermatitis of mouse skin and compound 48/80-treated HaCaT cells through its anti-inflammatory activity via its anti-oxidant activity(6) as well as its cytoprotective effects against UVB in detoxifying enzymes in human dermal fibroblasts against UVB-irradiated oxidative stress(7).

Dr. Feng LL and the colleagues at the , Nanjing University insisted that, the effectiveness of resveratrol in ameliorated ear swelling in a mouse model of picryl chloride-induced ear contact dermatitis, may be result from preventing the cells from entering S phase and G2/M phase during T cells activation(9).

Taking altogether, people who are at high risk of contact dermatitis due to family history, obesity, ioccupation,,..... should drink at least one serving daily and people with contact dermatitis should drink the smoothie as much as they can, depending to digestive toleration.

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References(1) Human skin safety test of green tea cell extracts in condition of allergic contact dermatitis by Kim HK1, Choi SY, Chang HK, Baek SY, Chung JO, Rha CS, Kim BJ, Kim MN.(PubMed)
(2) Topical application of green and white tea extracts provides protection from solar-simulated ultraviolet light in human skin by Camouse MM1, Domingo DS, Swain FR, Conrad EP, Matsui MS, Maes D, Declercq L, Cooper KD, Stevens SR, Baron ED.(PubMed)
(3) Cutaneous photoprotection from ultraviolet injury by green tea polyphenols by Elmets CA1, Singh D, Tubesing K, Matsui M, Katiyar S, Mukhtar H.(PubMed)
(4) Attenuation of experimental TPA-induced dermatitis by acetylenic acetogenins is associated with inhibition of PLA₂ activity by Otuki MF1, Schwob O, Silveira Prudente A, Zaltsman I, Meretski S, Segal J, Yedgar S, Rosenblat G.(PubMed)
(5) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(6) Ethanol Extract of Peanut Sprout Exhibits a Potent Anti-Inflammatory Activity in Both an Oxazolone-InducedContact Dermatitis Mouse Model and Compound 48/80-Treated HaCaT Cells by Choi DI1, Choi JY1, Kim YJ1, Lee JB1, Kim SO2, Shin HT3, Lee SC1.(PubMed)
(7) Ethanol extract of peanut sprout induces Nrf2 activation and expression of antioxidant and detoxifying enzymes in human dermal fibroblasts: implication for its protection against UVB-irradiated oxidative stress by Choi JY1, Choi DI, Lee JB, Yun SJ, Lee DH, Eun JB, Lee SC.(PubMed)

Most Common Diseases of elder: Chronic obstructive pulmonary disease (COPD) (Respiratory Disease): The Diet

1. Neotropical blueberry and barley leaves
In the study of four flavone C-glycosides, isoorientin (1), orientin (2), vitexin (3), and isovitexin (4), isolated from the neotropical blueberry, using antioxidant activity-guided fractionation, found that he four flavone C-glycosides exhibited inhibitory activity against IL-8 production and MMP-1 expression, with compounds 1, 3, and 4 having the most potent inhibitory activities in both assays at 100 μg/ml(1).
2. Turmeric
Cadmium is a toxic metal present in the environment and its inhalation can lead to pulmonary disease such as lung cancer and chronic obstructive pulmonary disease. These lung diseases are characterized by chronic inflammation. In the study of Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium, researchers found that the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells. In conclusion, curcumin could be used to prevent airway inflammation due to cadmium inhalation(2).
3. Oats, sweet corn and rice
Oats, sweet corn and rice contain measurable amounts of melatonin. In recent studies show that, α, β-unsaturated aldehyde acrolein in CS induces the production of interleukin (IL)-8, which is known to be related to bronchitis, rhinitis, pulmonary fibrosis, and asthma. In addition, lung and pulmonary fibroblasts secrete IL-8, which has a chemotactic effect on leukocytes, and which in turn, play a critical role in lung inflammation. Acrolein-induced IL-8 production was accompanied by increased levels of phosphorylation of Akt and extracellular signal-regulated kinases (ERK1/2) in HPFs, and that melatonin suppressed IL-8 production in HPFs. These results suggest that melatonin suppresses acrolein-induced IL-8 production via ERK1/2 and phosphatidylinositol 3-kinase (PI3K)/Akt signal inhibition in HPFs(3).
4. Grape skin
In the study of the effects of grape skin in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD), showed that alteration of the oxidant-antioxidant balance is important in the pathogenesis of CS-induced ALI and suggests lung protective effects of GSE treatment in the mouse(4).
5. Grape skin, seed and red wine
In the study to investigate the effect of dexamethasone versus resveratrol on the release of COPD-related inflammatory mediators (IL-6, IL-8, GM-CSF and MCP-1) and matrix-metalloprotease-9 (MMP-9) from alveolar macrophages exposed to gram-negative bacterial endotoxin (lipopolysaccharide, LPS), found that resveratrol almost completely reduced the release of all cytokines and MMP-9 without significant differences between the cohorts. Our data provide evidence for a corticosteroid resistance of alveolar macrophage-dependent inflammatory responses induced by gram-negative bacteria in COPD and thus question the utility of corticosteroids in COPD therapy. Instead, resveratrol may prove an alternative(5).
6. Etc.

The Smoothie of Banana, Avocado and Herbal Ginger Tea for Prevention and Treatment of Hyperemesis gravidarum in Pregnancy

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Hyperemesis gravidarum(Liver disease)

Yield: 2 servings (about 8 ounces each)

1 cup banana

1/2 cup avocado

1 cup herbal ginger tea

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of intrahepatic cholestasis of pregnancy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Hyperemesis gravidarum of pregnancy is a medical condition with severe nausea, vomiting, weight loss, and electrolyte disturbance during pregnancy. The prevalence of hyperemesis gravidarum of

pregnancy, may be associated to the presence of serum levels of neopterin, as a marker for immune system activation, inflammatory markers and oxidative stress(1)(2), particular Vitamin E, E equivalent, vitamin C, carotene and vitamin A levels(3).

Recent studies back by well known institutions proposed, Banana(7), Avocado(7) and Herbal Ginger Tea(4) may be the next generation of natural ingredients for prevention and treatment of hyperemesis gravidarum.

Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc. According to the University of Copenhagen, powdered root of ginger in daily doses of 1 g during 4 day, scored an significantly geater relief of the symptoms hyperemesis gravidarum in comparison to placebo(4).

Dr. Sonkusare S. professor at the Melaka Manipal Medical College, said, "The management of the (hyperemesis gravidarum)condition involves symptomatic treatment along with antiemetic, pyridoxine and thiamine. Important role of alternative therapies like ginger and P6 acupoint stimulation in the treatment of hyperemesis has been identified"(5).

Truly, the search of Medline, Embase, The Cochrane Library, and other important databases up to September 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review) by Festin M, professor at the Philippine General Hospital, suggested, alternative medicine of ginger root may also be effective for reduced risk and treatment of hyperemesis gravidarum when used combination with acupressure; acupuncture; corticosteroids; metoclopramide; ondansetron; prochlorperazine; promethazine; and pyridoxine (vitamin B6)(6).

Pyridoxine, also known as vitamin B6 found abundantly in bananas, and avocados is also found to associate to reduce risk and treatment of Hyperemesis gravidarum(7).

According to the case of Naval Medical Center, in a double-blind, randomized, controlled trial in which women with nausea and vomiting of pregnancy, showed that the combination of pyridoxine and doxylamine relieved symptoms of nausea and emesis in pregnancy but lesser than those of ondansetron(8).

The effectiveness of Banana, Avocado and Herbal Ginger Tea may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for prevention and treatment of hyperemesis gravidarum with little or no adverse effects.

Women who are at high risk of hyperemesis gravidarumdue to family history, previous pregnancy..... should drink at least one serving daily and women with hyperemesis gravidarumshould drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary patter change are recommended.

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References
(1) Serum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum by Tunc SY1, Agacayak E1, Budak S2, Tunc N3, Icen MS1, Findik FM1, Ekinci A4, Gul T1.(PubMed)
(2) The oxidative stress index increases among patients with hyperemesis gravidarum but not in normal pregnancies by Yilmaz S, Ozgu-Erdinc AS, Demirtas C, Ozturk G, Erkaya S, Uygur D.(PubMed)
(3) Dietary antioxidant levels in hyperemesis gravidarum: a case control study by Celik F1, Guzel AI, Kuyumcuoglu U, Celik Y.(PubMed)
(4) Ginger treatment of hyperemesis gravidarum by Fischer-Rasmussen W1, Kjaer SK, Dahl C, Asping U.(PubMed)
(5) Hyperemesis gravidarum: a review. by Sonkusare S1.(PubMed)
(6) Nausea and vomiting in early pregnancy by Festin M1.(PubMed)
(7) [Treatment of hyperemesis gravidarum with combined inositol and pyridoxine].[Article in Italian] by BALESTRI F.(PubMed)
(8) Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial by Oliveira LG1, Capp SM, You WB, Riffenburgh RH, Carstairs SD.(PubMed)

Monday, February 1, 2016

The Fabulous Smoothie of Tomato, Grape and Green Tea for Reduced Risk and Treatment of Bowen's disease (BD)

It is hard to image that a curable smoothie with detoxified property may have a potential in reduced risk of the disease in people who constantly involved to the exposure to arsenic. But due to lack of knowledge of the progression of the diseases in early stage of skin cancer in general population, the finding of these natural ingredients has run into many obstacles.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. The herb has been used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc. Its phytochemical curcumin exhibited anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against many types of cancers, including skin cancer(4).

In the phase I clinical trial, researchers suggested that curcumin may be the next potential in the chemoprevention of cancer due to its biologic effect(3).

When used conjunction with LED blue light united red light irradiation, curcumin induced a higher efficiency of regulating proliferation and apoptosis in skin keratinocytes in skin cancer(5).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects.

Its antioxidant (-)-Epigallocatechin-3-gallate (EGCG), has shown effectively in inhibited development of melanoma and nonmelanoma skin cancers(7), through its chemopreventive activity(8).
Dr. Katiyar SK, researcher at the Birmingham Veterans Affairs Medical Center said," The DNA repair by GTPs is mediated through the induction of interleukin (IL)-12(Pro inflammatory cytokine) which has been shown to have DNA repair ability"(6).

Myricetin is a flavonol, belongings to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, used in folk medicine as antioxidant to lower cholesterol, treat certain types of cancer, etc. According to the Kyungpook National University, the phytochemical inhibited the skin cancer formation through its effect on cancer cell cycle division in SKH1-Elite Mice model(9) as well as suppressing UVB-induced cyclooxygenase-2 (COX-2) expression of pain and inflammation of mouse skin epidermal JB6 P+ cells(10) in the early stage of non-melanoma skin cancer(11).

The effectiveness of Tomato, Grape and Green Tea phytochemicals on Bowen's disease (BD) may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk treatment of stroke with little or no adverse effects.
People who are at high risk of Bowen's disease (BD) due to family history, obesity,..... should drink at least one serving daily and people with Bowen's disease (BD) should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary patter change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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References

(1) The mechanistic basis of arsenicosis: pathogenesis of skin cancer by Hunt KM1, Srivastava RK2, Elmets CA2, Athar M3.(PubMed)

(2) Involvement of mtDNA damage elicited by oxidative stress in the arsenical skin cancers by Lee CH1, Wu SB, Hong CH, Chen GS, Wei YH, Yu HS.(PubMed)

(3) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions by Cheng AL1, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS,Pan MH, Wang YJ, Tsai CC, Hsieh CY.(PubMed)

(4) Biological and therapeutic activities, and anticancer properties of curcumin by Perrone D1, Ardito F1, Giannatempo G1, Dioguardi M1, Troiano G1, Lo Russo L1, DE Lillo A1, Laino L1, Lo Muzio L1.(PubMed)

(5) Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin by Niu T1, Tian Y2, Cai Q3, Ren Q3, Wei L3.(PubMed)

(6) Green tea prevents non-melanoma skin cancer by enhancing DNA repair by Katiyar SK1.(PubMed)

(7) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK.(PubMed)

(8) (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity by Barthelman M1, Bair WB 3rd, Stickland KK, Chen W, Timmermann BN, Valcic S, Dong Z, Bowden GT.(PubMed)

(9) Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis by Kang NJ1, Jung SK, Lee KW, Lee HJ.(PubMed)

(10) Myricetin suppresses UVB-induced skin cancer by targeting Fyn by Jung SK1, Lee KW, Byun S, Kang NJ, Lim SH, Heo YS, Bode AM, Bowden GT, Lee HJ, Dong Z.(PubMed)

(11) Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes by Kim W1, Yang HJ, Youn H, Yun YJ, Seong KM, Youn B.(PubMed)

Most Common Diseases of elder: Chronic obstructive pulmonary disease (COPD) (Respiratory Disease): The Do and Do not's list

The Do and Do not's list

1. Quit smoking, if you don’t, do not try as smoking is the main cause of chronic obstructive pulmonary disease (COPD). People with low levels of the protein alpha-1 antitrypsin are susceptible to develop the disease. Tobacco smoke is a complex chemical aerosol containing at least 8000 chemical constituents, either tobacco derived or added by tobacco product manufacturers(29a)
2. If you working in the occupation in the environment exposure of exposures coal mine dust, silica, welding fume, textile dust, agricultural dust, cadmium fume, etc., please be cautious to avoid the development of the disease(30)
3. Prevent Vitamin D deficiency
In the study of the Effects of vitamin D on immune disorders with special regard to asthma, COPD and autoimmune diseases, researchers at the School of Medicine, Semmelweis University, showed that VD supplementation in most related studies reduced the prevalence of asthma. VD supplementation may be useful in the prevention or adjunct treatment of chronic obstructive pulmonary disease(31).
4. Vitamin C, D, E, A, beta and alpha carotene
In the study of a systematic literature review performed on the association of vitamins and COPD. The role of vitamin supplements in COPD, showed that various vitamins (vitamin C, D, E, A, beta and alpha carotene) are associated with improvement in features of COPD such as symptoms, exacerbations and pulmonary function. High vitamin intake would probably reduce the annual decline of FEV1(32).
5. Antioxidants
Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory lung diseases that are characterized by systemic and chronic localized inflammation and oxidative stress. In the study to elevate amounts of reactive oxygen species (ROS) released from inflammatory cells, increased levels of ROS, either directly or via the formation of lipid peroxidation products, may play a role in enhancing the inflammatory response in both asthma and COPD, researchers at the Novartis Institutes for Biomedical Research, showed that a combination of antioxidants may be effective in the treatment of asthma and COPD(33).
6. Eat your vegetables and fruit
In the study to assess whether the risk of certain chronic diseases can be reduced by increased consumption of vegetables or fruit by the general public, and what strength of evidence has to be allocated to such an association, showed that increasing the consumption of vegetables and fruit lowers the risk of certain eye diseases, dementia and the risk of osteoporosis. Likewise, current data on asthma, COPD, and RA indicate that an increase in vegetable and fruit consumption may contribute to the prevention of these diseases(34). Guidelines from the US National Cancer Institute (103) recommend consumption of five servings of fruit and vegetables daily, corresponding to a vitamin C intake exceeding 200 mg. Dietary surveys carried out in the US population indicate that less than 12 percent of US children and adults meet this recommended level of intake (104). Diet appears to be an important cofactor in the development of obstructive lung disease, although data are still sparse(32a).
7. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://respiratory-research.com/content/13/1/116/abstract
(29a) http://www.ncbi.nlm.nih.gov/pubmed/23227851
(30) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513231/
(31) http://www.ncbi.nlm.nih.gov/pubmed/23234453
(32) http://www.ncbi.nlm.nih.gov/pubmed/21134250
(32a) http://www.ncbi.nlm.nih.gov/pubmed/12192737