The Fabulous Smoothie of Tomato, Grape and Green Tea for Reduced Risk and Treatment of Bowen's disease (BD)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for reduced risk and treatment of Bowen's disease (BD)

Yield: 2 serving (about 8 ounce each)
3/4 cup tomatoes
3/4 cup grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Bowen's disease (BD) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Bowen's disease (BD), an early stage of skin disease with characteristics of red, scaly patch on the skin. There is a suggestion that the diseases in early stage of skin cancer  may be resulted of arsenic exposure  causes of oxidative stress and alternation of DNA(2), in the groundwater of many under developed countries, affecting 200 million people(1).

It is hard to image that a curable smoothie with detoxified property may have a potential in reduced risk of the disease in people who constantly involved to the exposure to arsenic. But due to lack of knowledge of the progression of the diseases in early stage of skin cancer in general population, the finding of these natural ingredients has run into many obstacles.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. The herb has been used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc. Its phytochemical curcumin exhibited anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against many types of cancers, including skin cancer(4).

 In the phase I clinical trial, researchers suggested that curcumin may be the next potential in the chemoprevention of cancer due to its biologic effect(3).

When used conjunction with LED blue light united red light irradiation, curcumin induced a higher efficiency of regulating proliferation and apoptosis in skin keratinocytes in skin cancer(5).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects.

Its antioxidant (-)-Epigallocatechin-3-gallate (EGCG), has shown effectively in inhibited development of melanoma and nonmelanoma skin cancers(7), through its chemopreventive activity(8).
Dr. Katiyar SK, researcher at the Birmingham Veterans Affairs Medical Center said," The DNA repair by GTPs is mediated through the induction of interleukin (IL)-12(Pro inflammatory cytokine) which has been shown to have DNA repair ability"(6).

Myricetin is a flavonol, belongings to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, used in folk medicine as antioxidant to lower cholesterol, treat certain types of cancer, etc. According to the Kyungpook National University, the phytochemical inhibited the skin cancer formation through its effect on cancer cell cycle division in SKH1-Elite Mice model(9) as well as suppressing UVB-induced cyclooxygenase-2 (COX-2) expression of pain and inflammation of mouse skin epidermal JB6 P+ cells(10) in the early stage of non-melanoma skin cancer(11).

The effectiveness of Tomato, Grape and Green Tea  phytochemicals on Bowen's disease (BD)  may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk treatment of stroke with little or no adverse effects.
People who are at high risk of Bowen's disease (BD) due to family history, obesity,..... should drink at least one serving daily and people with Bowen's disease (BD) should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary patter change are recommended.

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References

(1) The mechanistic basis of arsenicosis: pathogenesis of skin cancer by Hunt KM1, Srivastava RK2, Elmets CA2, Athar M3.(PubMed)

(2) Involvement of mtDNA damage elicited by oxidative stress in the arsenical skin cancers by Lee CH1, Wu SB, Hong CH, Chen GS, Wei YH, Yu HS.(PubMed)

(3) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions by Cheng AL1, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS,Pan MH, Wang YJ, Tsai CC, Hsieh CY.(PubMed)

(4) Biological and therapeutic activities, and anticancer properties of curcumin by Perrone D1, Ardito F1, Giannatempo G1, Dioguardi M1, Troiano G1, Lo Russo L1, DE Lillo A1, Laino L1, Lo Muzio L1.(PubMed)

(5) Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin by Niu T1, Tian Y2, Cai Q3, Ren Q3, Wei L3.(PubMed)

(6) Green tea prevents non-melanoma skin cancer by enhancing DNA repair by Katiyar SK1.(PubMed)

(7) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK.(PubMed)

(8) (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity by Barthelman M1, Bair WB 3rd, Stickland KK, Chen W, Timmermann BN, Valcic S, Dong Z, Bowden GT.(PubMed)

(9) Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis by Kang NJ1, Jung SK, Lee KW, Lee HJ.(PubMed)

(10) Myricetin suppresses UVB-induced skin cancer by targeting Fyn by Jung SK1, Lee KW, Byun S, Kang NJ, Lim SH, Heo YS, Bode AM, Bowden GT, Lee HJ, Dong Z.(PubMed)

(11) Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes by Kim W1, Yang HJ, Youn H, Yun YJ, Seong KM, Youn B.(PubMed)