Medical Advisor Journals

Tuesday, February 16, 2016

Most Common Diseases of elder: Upper respiratory tract infection(Respiratory Disease) – The Diseases associated to

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

Upper respiratory tract infection

Upper respiratory tract infections are considered to be the infection of the airway above the glottis or vocal cords. This includes the nose, sinuses, pharynx, and larynx, including the infection of tonsillitis, pharyngitis, laryngitis, sinusitis, etc,.

Diseases associated with Upper respiratory tract infection
1. Chlamydia infection
In humans the most common infections are caused by Chlamydophila pneumoniae is Chlamydia trachomatis.These pathogens are mainly responsible for infections of upper respiratory tract, infections of urinary tract and conjunctivitis(19).
2. Acute otitis media (AOM)
Acute otitis media (AOM) occurs as a complication of viral upper respiratory tract infections in young children. AOM and respiratory viruses both display seasonal variation. According to the study leaded by Department of Pediatrics, University of Utah Health Sciences Center, showed that During the study period, 96,418 respiratory viral tests were performed; 46,460 (48%) were positive. The most commonly identified viruses were: RSV (22%), rhinovirus (8%), influenza (8%), parainfluenza (4%), human metapneumovirus (3%), and adenovirus (3%). AOM was diagnosed during 271,268 ambulatory visits. There were significant associations between peak activity of RSV, human metapneumovirus, influenza A, and office visits for AOM. Adenovirus, parainfluenza, and rhinovirus were not associated with visits for AOM(20).
3. Streptococcus pneumoniae serotypes
Streptococcus pneumoniae serotypes associated with colonization of the upper respiratory tract in young children. According to the study by Medical University of Lublin of the 342 pneumococcal isolates, the serotype coverage by PCV-10 or PCV-13 was 73.7% or 80.1%, respectively. Moreover, 92.4% of the isolates belonged to serotypes included in the “old” 23-valent polysaccharide vaccine. A clear picture of the distribution of S. pneumoniae serotypes associated with colonization and/or infection in various geographical areas is needed in a light of recommended or routine vaccination(21).
4. Etc.
All Forms of Arthritis are Curable
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Sources
(19) http://www.ncbi.nlm.nih.gov/pubmed/22320048
(20) http://www.ncbi.nlm.nih.gov/pubmed/23249910
(21) http://www.ncbi.nlm.nih.gov/pubmed/23200561

The smoothie of Green Tea, Carrot and Strawberry for reduced Risk and Treatment of Fibroids back by Respectable Institutions

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and Treatment of Eczema
Yield: 2 serving (about 8 ounce each)
11/4 cup strawberry
1/4 cup carrot
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of fibroids is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Fibroids also known as uterine fibroids, is a condition of irregular cell growth of non cancerous tumor from the muscle layers of the uterus.
Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, such as Green tea(1), Turmeric(3) and Olive(7) for reduced risk and treatment for

fibroids.
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Its phytochemical, epigallocatechin gallate (EGCG), dramatically reduced the volume and weight of fibroids tumors at 4 and 8 weeks on rat leiomyoma (ELT3) cells in vitro and in a nude mice mode(1).

In a pilot randomized controlled clinical study, epigallocatechin gallate (EGCG) also inhibited the Uterine fibroids, significantly reduced fibroid-specific symptom severity as well as improved quality of life of patients(2).

Dr. Ozercan IH and the research team at the University of Firat said,"dietary supplementation with EGCG reduces the incidence and size of spontaneously occurring leiomyoma of the oviduct" in Japanese quail study(3).

Lycopene, a major phytochemical and antioxidant supplementation, found in tomato, exhibited a decreased incidence of leiomyomas in the oviduct of Japanese quail, according to the University of Firat(3).

According to Dr. Sahin K1 and research team at the Firat University, lycopene intake reduced risk leiomyomas (fibroids), benign tumors of the uterus affecting millions of women through its anti inflammatory activities in cell cycle arrest pathways(4).

In fact, in a 6627 incident cases of UL diagnosed by ultrasonography, dietary vitamin A is associated to reduce risk of uterine leiomyomata, according to the Slone Epidemiology Center at Boston University(5).

Flavonoid, a class of phytochemical found abundantly in strawberry, including apigenin and luteolin inhibited proliferation of of human leiomyomal smooth muscle cells, through significantly reduced cell numbers in culture, arrested cell proliferation, and induced cells apoptosis via down-regulated the IGF-I expression in growth hormone production(6).

Flavopiridol is a potent CDK inhibitor exhibited antiproliferative effect against Fibroids as flavonoid compound through cell cycle phase I arrest, according to the joint study lead by the Keimyung University School of Medicine(7).

The combined epigallocatechin gallate (EGCG), lycopene and apigenin and luteolin, found in green tea, carrot and strawberry respectively may contribute to further investigation of therapeutic natural ingredients for reduced risk and treatment of Fibroids

Women who are at increased risk of Fibroids due to family history, genetic mutation,... should drink at least one serving daily and women with Fibroids should drink as much as they can, depending to digestive toleration.

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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References
(1) Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice by Zhang D1, Al-Hendy M, Richard-Davis G, Montgomery-Rice V, Sharan C, Rajaratnam V, Khurana A, Al-Hendy A.(PubMed)
(2) Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study by Roshdy E1, Rajaratnam V, Maitra S, Sabry M, Allah AS, Al-Hendy A.(PubMed)
(3) Chemoprevention of fibroid tumors by [-]-epigallocatechin-3-gallate in quail by Ozercan IH1, Sahin N, Akdemir F, Onderci M, Seren S, Sahin K, Kucuk O.(PubMed)
(4) Lycopene supplementation prevents the development of spontaneous smooth muscle tumors of the oviduct in Japanese quail by Sahin K1, Ozercan R, Onderci M, Sahin N, Gursu MF, Khachik F, Sarkar FH, Munkarah A, Ali-Fehmi R, Kmak D, Kucuk O.(PubMed)
(5) Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata by Wise LA1, Radin RG, Palmer JR, Kumanyika SK, Boggs DA, Rosenberg L.(PubMed)
(6) Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds by Kim DI1, Lee TK, Lim IS, Kim H, Lee YC, Kim CH.(PubMed)
(7) Antitumor effects of flavopiridol on human uterine leiomyoma in vitro and in a xenograft model by Lee HG1, Baek JW2, Shin SJ3, Kwon SH3, Cha SD3, Park WJ3, Chung R1, Choi ES3, Lee GH2, Cho CH4.(PubMed)

The Never failed Smoothie of Green Tea and Grape for Reduced Risk and Treatment of Colitis

1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for reduced risk and treatment of colitis without induced adverse effect is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.

Colitis is a condition of inflammation of the large intestine, including the colon, cecum and rectum.

Recent studies by respectable institutions suggested that green tea(1) may be next potential ingredients for reduced risk and treatment of colitis. According to the joint study lead by the Universiti Putra Malaysia, Gallic acid, a biochemical found in green tea inhibited inflammatory bowel disease, through reduction of oxidative stress in in a dextran sulfate sodium (DSS)-induced mouse colitis model(1).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

High dose of EGCG and green tea inhibited colitis in rodent model, but the effectiveness may be limited due to species differences in xenobiotic metabolism and microbiota, according to Dr. Martin DA and Dr. Bolling BW.(2).

In the finding of the method for controlling the symptoms of autoimmune chronic inflammatory bowel disease (IBD), in Colitis Models, Green tea (GrTP and EGCG) significantly restored ahepatic and colonic antioxidants levels and attenuated severity of colitis in comparison to sulfasalazine(3).

Procyanidins (ACT), a natural biologically active compound extracted from apple and grape seed, may also be next generation natural ingredient for treatment of colitis as it decreased the severity of selected markers of DSS-induced colitis in the distal ileum and proximal colon(5).

In experimental models of colitis induced by dextran sulfate sodium (DSS) or oxazolone inhibited bowel inflammatory diseases through combined anti-inflammatory and immunomodulatory effects(4), according to the National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo.

Resveratrol, another biochemical found abundantly in grape exhibited anti chronic intestinal inflammatory disease, through its antioxidative defense against production of reactive oxygen species (ROS) and disturbed capacity(6), inflammatory cytokines as well as suppressed intestinal tumorigenesis through miRNA modulation(7).
The study by the Department of Food Science and Technology, CEBAS-CSIC said, "(oral administration of )different resveratrol prodrugs and pro-prodrugs did not develop colitis symptoms and improved 6-fold the disease activity index (DAI) compared to resveratrol"(8).
In support to the effectiveness of esveratrol, the University of Hong Kong study, suggested intragastric administration of 2,3',4,4',5'-pentamethoxy-trans-stilbene (PMS) (25, 50 mg.kg(-1) body weight), a derivative of resveratrol for 16 weeks significantly reduced the multiplicity of colonic neoplasms by 15% and 35% respectively(9).

This discover of the effectiveness of Green Tea and grape phytochemicals may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk and treatment of colitis with little or no adverse effects.
People who are at high risk of colitis due to family history, obesity,..... should drink at least one serving daily and people with colitis should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary pattern change are recommended.

References

(1) Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice by Pandurangan AK1, Mohebali N2, Norhaizan ME3, Looi CY2.(PubMed)

(2) A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases by Martin DA1, Bolling BW.(PubMed)

(3) Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models by Oz HS1, Chen T, de Villiers WJ.(PubMed)

(4) Orally administered apple procyanidins protect against experimental inflammatory bowel disease in mice by Yoshioka Y1, Akiyama H, Nakano M, Shoji T, Kanda T, Ohtake Y, Takita T, Matsuda R, Maitani T.(PubMed)

(5) Grape seed extract reduces the severity of selected disease markers in the proximal colon of dextran sulphate sodium-induced colitis in rats by Cheah KY1, Bastian SE, Acott TM, Abimosleh SM, Lymn KA, Howarth GS.(PubMed)

(6) Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats by Yildiz G, Yildiz Y, Ulutas PA, Yaylali A, Ural M1.(PubMed)

(7) Role of microRNAs in resveratrol-mediated mitigation of colitis-associated tumorigenesis in Apc(Min/+) mice by Altamemi I1, Murphy EA1, Catroppo JF1, Zumbrun EE1, Zhang J1, McClellan JL1, Singh UP1, Nagarkatti PS1, Nagarkatti M2.(PubMed)

(8) Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents by Larrosa M1, Tomé-Carneiro J, Yáñez-Gascón MJ, Alcántara D, Selma MV, Beltrán D, García-Conesa MT, Urbán C, Lucas R, Tomás-Barberán F, Morales JC,Espín JC.(PubMed)

(9) 2,3',4,4',5'-Pentamethoxy-trans-stilbene, a resveratrol derivative, inhibits colitis-associated colorectal carcinogenesis in mice by Li H1, Wu WK, Li ZJ, Chan KM, Wong CC, Ye CG, Yu L, Sung JJ, Cho CH, Wang M.(PubMed)

Most Common Diseases of elder: Upper respiratory tract infection(Respiratory Disease) – The Types

1. Rhinitis
Rhinitis is defined as a condition of irritation and inflammation of the nasal mucosa. In most case, it is caused by allergic reaction, with symptoms of stuffy nose, runny nose, and post-nasal drip. According to the article of Economic Impact and Quality-of-Life Burden of Allergic Rhinitis, the disease affects over 30% of US population(8).

2. Rhinosinusitis or sinusitis
Rhinosinusitis or Sinusitis(9) is defined as a condition of inflammation of the paranasal sinuses, including frontal, ethmoid, maxillary, and sphenoid of which can develop headache as a result of exposure to a cold or flu virus, or an allergic reaction to pollen, mold, dust or smoke, etc..Sinusitis affects 37 million people each year. The diseases affects more than 24 million population in U.S. annually(10).

3. Nasopharyngitis
Also known as rhinopharyngitis or the common cold s defined as a Inflammation of the inflammation of the nasopharynx. Symptoms of can be relieved in children, by acetaminophen without any combination is as effective as OTC drugs containing acetaminophen, decongestant, and antihistaminics(11).

4. Pharyngitis
Pharyngitis, also known as sore throat is defined as a condition of inflammation of the pharynx, hypopharynx, uvula, and tonsils. The application of laripront has been reported as the positive outcome of the treatment in children that was especially efficacions in the patients with acute pathologies(12).

5. Epiglottitis (supraglottitis)
Epiglottitis is defined as a condition of inflammation of the tissue that covers the trachea (windpipe). Epiglottitis, in some some can be misdiagnosed with other disease, such as acute laryngo-tracheo-bronchitis. There is a report of a the case of a 20-month-old child who required admission to the intensive care with a presumptive diagnosis of acute laryngo-tracheo-bronchitis, for the management of acute upper airway obstruction. This child had received a complete course of Haemophilus influenzae type B (Hib) vaccine. Subsequent events showed that the diagnosis was not laryngo-tracheo-bronchitis but acute epiglottitis(13).

6. Laryngitis
Laryngitis is defined as condition of inflammation of the larynx. The disease can cause hoarse voice or the complete loss of the voice as it affects the vocal cords. Antibiotics appear to have no benefit in treating acute laryngitis, but antibiotic such as Erythromycin, could reduce voice disturbance at one week and cough at two weeks when measured subjectively(14).

7. Laryngotracheitis
Laryngotracheitis is defined as conditions of inflammation of the laryngitis and tracheitis. Many practitioners have considered that steroids, with their anti-inflammatory properties, should be efficacious in the treatment of acute laryngotracheitis(15).

8. Tracheitis
Tracheitis is defined as a condition of inflammation of the trachea and subglottic area. Bacterial tracheitis needs a high index of suspicion because of its varied presentations. Certain forms have less severe clinical manifestations. These forms also require aggressive management as they can result in airway obstruction from membranes and edema(16).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(8) http://www.medscape.com/viewarticle/472667_2
(9) http://medicaladvisorjournals.blogspot.ca/2012/04/sinusitissinus-headache-symptoms-causes.html
(10) http://www.amjmed.com/article/S0002-9343%2810%2900098-7/abstract
(11) http://www.ncbi.nlm.nih.gov/pubmed/17560664
(12) http://www.ncbi.nlm.nih.gov/pubmed/23250535
(13) http://www.ncbi.nlm.nih.gov/pubmed/10597562
(14) http://www.ncbi.nlm.nih.gov/pubmed/17443555
(15) http://www.ncbi.nlm.nih.gov/pubmed/5324105
(16) http://www.ncbi.nlm.nih.gov/pubmed/21975496

Monday, February 15, 2016

The Neverfailed Smoothie of Green Tea, Grape and Apple for Prevention and Treatment of Ulcerative colitis

1/4 cup artichoke
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of ulcerative colitis without induced adverse effects is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.
Recent studies reported by some renowned institutions suggested that green tea, grape and artichoke may process a potential effect as a therapeutic ingredients for reduced risk and treatment of ulcerative colitis through improved immunity in suppression the proinflammatoty cytokines(1).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.
Ulcerative colitis another form of inflammatory bowel disease (IBD), causeing inflammation and ulcers in the colon. According to the University of Kentucky Medical Center, green tea polyphenols (GrTP, EGCG) improved antioxidants levels and attenuated severity of side effect caused by intake of sulfasalazine, by exhibiting anti-inflammatory properties(2).

Epidemiological studies not only strongly confirm the effectiveness of green tea for reduced risk and treatment of ulcerative colitis(4), but also also suggested change of dietary pattern and reduced stress may be helpful to speed up the recovery of the disease(3).

Resveratrol, an phytochemical found abundantly in grape seed and skin is a class of Stilbenoids. Epidemiologically, the antioxidant has found effectively for treatment Ulcerative Colitis due to its protective effect against inflammation, according to a randomized, double-blind, placebo-controlled pilot Study(5).

In animal study, resveratrol showed to restore balance of T cells (Treg), which play prominent roles in immune functions against autoimmine disease(7), through regulating the pro inflammatory cytokine IL-6(6).

Through it antioxidant effects, resveratrol also inhibited the extreme oxidative properties of trinitrobenzene sulfonic acid (TNBS in -induction of ulcerative-colitis, Dr Abdallah DM and Dr. Ismael NR. said(8).

Silymarin, a phytochemical in the class of Lignans (phytoestrogens), found abundantly in artichokes, also expressed its anti ulcerative colitis through down regulating various pro-inflammatory cytokines(9). According to a randomized, double blinded, placebo-controlled clinical trial, silymarin may be considered as a natural supplement used in UC patients to maintain remission(10).

This discover of the effectiveness of Green Tea and grape and artichoke phytochemicals may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk and treatment of ulcerative colitis with little or no adverse effects.

People who are at high risk of ulcerative colitis due to family history, obesity,..... should drink at least one serving daily and people with ulcerative colitis should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary pattern change are recommended.

References

(1) A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis. by Dryden GW1, Lam A, Beatty K, Qazzaz HH, McClain CJ. (PubMed)

(2) Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models by Oz HS1, Chen T, de Villiers WJ.(PubMed)

(3) Multicenter case-control study of the risk factors for ulcerative colitis in China by Wang YF1, Ou-Yang Q, Xia B, Liu LN, Gu F, Zhou KF, Mei Q, Shi RH, Ran ZH, Wang XD, Hu PJ, Wu KC, Liu XG, Miao YL, Han Y, Wu XP, He GB, Zhong J, Liu GJ.(PubMed)

(4) [Anti-inflammatory effects of tea-flavonoids].[Article in German]by Hoensch H1, Oertel R.(PubMed)
(5) Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study by Samsami-Kor M1, Daryani NE2, Asl PR3, Hekmatdoost A4.(PubMed)
(6) IL-6: regulator of Treg/Th17 balance by Kimura A1, Kishimoto T.(PubMed)
(7) Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in mice by Yao J1, Wei C1, Wang JY1, Zhang R1, Li YX1, Wang LS1.(PubMed)
(8) Resveratrol abrogates adhesion molecules and protects against TNBS-induced ulcerative colitis in rats by Abdallah DM1, Ismael NR.(PubMed)
(9) Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. by Gupta SC1, Tyagi AK1, Deshmukh-Taskar P1, Hinojosa M1, Prasad S1, Aggarwal BB2.(PubMed)
(10) A randomized, double blinded, placebo-controlled clinical trial of silymarin in ulcerative colitis by Rastegarpanah M1,2,3, Malekzadeh R1, Vahedi H1, Mohammadi M4, Elahi E1, Chaharmahali M1, Safarnavadeh T1, Abdollahi M5,6.(PubMed)

Most Common Diseases of elder: Upper respiratory tract infection(Respiratory Disease) – The Causes and Risk factors

The Causes and Risk factors
The Causes
Upper respiratory tract infections are most likely to be caused by viral infection. The sicknesses are
are spread from person to person by spreading from person to person in respiratory droplets through sneezing or coughing and individual are infected with the virus before symptoms arise. It is advised to cover sneezes and coughs, and regular hand washing should provide some protection duringthe season of the common cold and influenza (flu).In the study of the influenza A virus, one of the leading causes of respiratory tract infections in humans, found that various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells(4). Other study indicated that Influenza viruses cause annual outbreaks of respiratory tract infection with attack rates of 5-10%. During attack, strain-specific antibody responses are induced, which exert selective pressure on circulating influenza viruses and which drive antigenic drift of seasonal influenza viruses, especially in the hemagglutinin molecule. This antigenic drift necessitates updating of seasonal influenza vaccines regularly in order to match the circulating strains(5).

The Risk factors
1. Age
Young children and elder are susceptible to the infection by virus in cold and flu season as a result of immature and weakened immune system, accordingly.
2. Antibiotic resistance
Upper respiratory tract infections (URTIs) are common in children. The cause of URTIs is usually viral, but parents’ attitudes often contribute to inappropriate prescription of antibiotics, promoting antibiotic resistance. The risk factors of being a father, having low education, having immigrant status, being a single parent, having low income, having <2 or >3 children, living in the islands, and being without experience in recurrent URTIs were significantly associated to inadequate knowledge, inappropriate attitudes, and wrong practices(6).
3. Weakened Immune system
People with Weakened Immune system as a result of the chronic illness, may at increased risk of cold and flu. In the study to assess the effects of CHS on host innate immunity and avian influenza virus H5N1 infection in mice, found that The CHS treatment group exhibited reduced local immunity in the respiratory tract, including the number of pulmonary alveolar macrophages and lesions in the nasal mucosa, trachea, and lungs(7).
4. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(4) http://www.ncbi.nlm.nih.gov/pubmed/23170167
(5) http://www.ncbi.nlm.nih.gov/pubmed/21963677
(6) http://www.ncbi.nlm.nih.gov/pubmed/23209933
(7) http://www.ncbi.nlm.nih.gov/pubmed/21687549

Sunday, February 14, 2016

The Neverfailed Smoothie of Green Tea, Grape and Apple for Prevention and Treatment of Crohn's disease

1/2 cup apple
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of Crohn's disease is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.

Crohn's disease is a condition of inflammatory bowel diseases(IBD), effecting any part ( from the mouth to the end of the rectum) of gastrointestinal diseases. Childhood immunological, hygiene and dietary intake are environment factors associated to the development of IBD(1).

Scientist at the some research centers may have found the way to reduce risk and treatment of bowel inflammatory disease such as Crohn's disease. Green tea(2), Grape(5) and pumpkins(1) may be one of the findings with potential and pharmaceutical ingredients.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

According to the study by the Fachpraxis für Innere Medizin und Gastroenterologie,, green tea, epigallocathechin gallate and apigenin inhibited proinflammaory cytokines, chemokines and activated immune cells in vivo and in vitro(2).

Dr. Melgarejo E and colleagues at the Universidad de Málaga and CIBER de Enfermedades Raras (CIBERER), said," Bioactive compound epigallocatechin-3-gallate (EGCG), a major component of green tea, ... have potent anti-inflammatory, anti-tumoral, and anti-angiogenic effects and to be a potent inhibitor of the histamine-producing enzyme, histidine decarboxylase"(3).In support of the effects of green tea in reduced risk and treatment of Inflammatory bowel disease (IBD) including Crohn's disease (CD), the University of Bradford suggested, " flavonoids (found in green tea) could be very effective in the treatment of oxidative stress and encouraged in the diet of IBD patients"(4)

Resveratrol, the major chemical compound found in grape prohibited that stricture formation in Crohn's disease by exhibiting the decrease of intestinal smooth muscle cell numbers through cell cycle arrest and apoptosis(5). According to the The University of Texas M. D. Anderson Cancer Center, as a polyphenol, resveratrol, also have potential against various pro-inflammatory diseases, including Crohn's disease(6).

In animal model, resveratrol treatment reduce inflammation and hereby to increase resistance to the development and progression of bowel inflammatory effect through its strong antioxidants and inhibitorsof cytokines(7).

Other phytochemical including naringenin found abundantly in apple may ne aonther potential polyphenol against various pro-inflammatory diseases(6).
also inhibited bowel inflammatory diseases through modulating the TNF-mediated inflammatory response, including cell death, survival, differentiation, proliferation and migration(8) against these pro-inflammatory diseases(9).

This finding of the effectiveness of Green Tea and grape and apple phytochemicals may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk and treatment of Crohn's disease with little or no adverse effects.
People who are at high risk of Crohn's disease due to family history, obesity,..... should drink at least one serving daily and people with Crohn's disease should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary pattern change are recommended.

References
(1) Environmental risk factors in inflammatory bowel disease: a population-based case-control study in Asia-Pacific by Ng SC1, Tang W1, Leong RW2, Chen M3, Ko Y2, Studd C4, Niewiadomski O4, Bell S4, Kamm MA5, de Silva HJ6, Kasturiratne A6, Senanayake YU6, Ooi CJ7,Ling KL7, Ong D8, Goh KL9, Hilmi I9, Ouyang Q10, Wang YF10, Hu P3, Zhu Z3, Zeng Z3, Wu K11, Wang X11, Xia B12, Li J12, Pisespongsa P13, Manatsathit S14,Aniwan S15, Simadibrata M16, Abdullah M16, Tsang SW17, Wong TC18, Hui AJ19, Chow CM20, Yu HH21, Li MF21, Ng KK22, Ching J1, Wu JC1, Chan FK1, Sung JJ1; Asia-Pacific Crohn's and Colitis Epidemiology Study ACCESS Group.(PubMed)

(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)

(3) Targeting of histamine producing cells by EGCG: a green dart against inflammation? by Melgarejo E1, Medina MA, Sánchez-Jiménez F, Urdiales JL.(PubMed)

(4) Flavonoids inhibit the genotoxicity of hydrogen peroxide (H(2)O(2)) and of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD) by Najafzadeh M1, Reynolds PD, Baumgartner A, Anderson D.(PubMed)

(5) Resveratrol causes cell cycle arrest, decreased collagen synthesis, and apoptosis in rat intestinal smooth muscle cells by Garcia P1, Schmiedlin-Ren P, Mathias JS, Tang H, Christman GM, Zimmermann EM.(PubMed)

(6) Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols by Gupta SC1, Tyagi AK1, Deshmukh-Taskar P1, Hinojosa M1, Prasad S1, Aggarwal BB2.(PubMed)

(7) Plant-derived health: the effects of turmeric and curcuminoids by Bengmark S1, Mesa MD, Gil A.(PubMed)

(8) TNF-mediated inflammatory disease by Bradley JR1.(PubMed)

(9) Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols by Gupta SC1, Tyagi AK1, Deshmukh-Taskar P1, Hinojosa M1, Prasad S1, Aggarwal BB2.(PubMed)