Monday, February 15, 2016

The Neverfailed Smoothie of Green Tea, Grape and Apple for Prevention and Treatment of Ulcerative colitis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of ulcerative colitis  
Yield: 2 servings (about 8 ounces each)
1 1/4 cups grape
1/4 cup artichoke
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of ulcerative colitis without induced adverse effects is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.
Recent studies reported by some renowned institutions suggested that green tea, grape and artichoke may process a potential effect as a therapeutic ingredients for reduced risk and treatment of ulcerative colitis through improved immunity in suppression the proinflammatoty cytokines(1).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.
Ulcerative colitis another form of inflammatory bowel disease (IBD), causeing inflammation and ulcers in the colon. According to the University of Kentucky Medical Center, green tea polyphenols (GrTP, EGCG) improved antioxidants levels and attenuated severity of side effect caused by intake of sulfasalazine, by exhibiting anti-inflammatory properties(2).
Epidemiological studies not only strongly confirm the effectiveness of green tea for reduced risk and treatment of ulcerative colitis(4), but also also suggested change of dietary pattern and reduced stress may be helpful to speed up the recovery of the disease(3).

Resveratrol, an phytochemical found abundantly in grape seed and skin is a class of Stilbenoids. Epidemiologically, the antioxidant has found effectively for treatment Ulcerative Colitis due to its protective effect against inflammation, according to a randomized, double-blind, placebo-controlled pilot Study(5).
In animal study, resveratrol showed to restore balance of T cells (Treg), which play prominent roles in immune functions against autoimmine disease(7), through regulating the pro inflammatory cytokine IL-6(6).
Through it antioxidant effects, resveratrol also inhibited the extreme oxidative properties of trinitrobenzene sulfonic acid (TNBS in -induction of ulcerative-colitis, Dr Abdallah DM and Dr. Ismael NR. said(8).

Silymarin, a phytochemical in the class of Lignans (phytoestrogens), found abundantly in artichokes, also expressed its anti ulcerative colitis through down regulating various pro-inflammatory cytokines(9). According to a randomized, double blinded, placebo-controlled clinical trial, silymarin may be considered as a natural supplement used in UC patients to maintain remission(10).

This discover of the effectiveness of Green Tea and grape and artichoke phytochemicals may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk and treatment of  ulcerative colitis with little or no adverse effects.

People who are at high risk of  ulcerative colitis due to family history, obesity,..... should drink at least one serving daily and people with  ulcerative colitis should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary pattern change are recommended.

(1) A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis. by Dryden GW1, Lam A, Beatty K, Qazzaz HH, McClain CJ. (PubMed)
(2) Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models by Oz HS1, Chen T, de Villiers WJ.(PubMed)
(3) Multicenter case-control study of the risk factors for ulcerative colitis in China by Wang YF1, Ou-Yang Q, Xia B, Liu LN, Gu F, Zhou KF, Mei Q, Shi RH, Ran ZH, Wang XD, Hu PJ, Wu KC, Liu XG, Miao YL, Han Y, Wu XP, He GB, Zhong J, Liu GJ.(PubMed)
(4) [Anti-inflammatory effects of tea-flavonoids].[Article in German]by Hoensch H1, Oertel R.(PubMed)
(5) Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study by Samsami-Kor M1, Daryani NE2, Asl PR3, Hekmatdoost A4.(PubMed)
(6) IL-6: regulator of Treg/Th17 balance by Kimura A1, Kishimoto T.(PubMed)
(7) Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in mice by Yao J1, Wei C1, Wang JY1, Zhang R1, Li YX1, Wang LS1.(PubMed)
(8) Resveratrol abrogates adhesion molecules and protects against TNBS-induced ulcerative colitis in rats by Abdallah DM1, Ismael NR.(PubMed)
(9) Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. by Gupta SC1, Tyagi AK1, Deshmukh-Taskar P1, Hinojosa M1, Prasad S1, Aggarwal BB2.(PubMed)
(10) A randomized, double blinded, placebo-controlled clinical trial of silymarin in ulcerative colitis by Rastegarpanah M1,2,3, Malekzadeh R1, Vahedi H1, Mohammadi M4, Elahi E1, Chaharmahali M1, Safarnavadeh T1, Abdollahi M5,6.(PubMed)

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