The Smoothie of Green Tea, Blueberry and Grape for Prevention and Treatment of Mouth (Oral) cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Mouth (Oral) cancer
Yield: 2 serving (about 8 ounce each)
3/4 cup blueberry
3/4 cup grape
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  Lichen planus has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by renowned institutions, conveyed that green tea(3) may be holding a key for extracting natural ingredient for reduced early onset and treatment of Mouth (Oral) cancer.

Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the First Hospital of Jilin University, green tea extract (GTE) inhibited three human oral squamous carcinoma
cell lines (CAL-27, SCC-25 and KB), through cell cycle arrest in S and G2/M phases(1).Green tea polyphenol, (-)-epigallocatechin-3-gallate, another major phytochemical, not only can induce oxidative stress in oral cancer cells but exerts antioxidant effects in normal cells(2).
Furthermore, in 14 articles with 19 studies comprising 4675 oral cancer cases were included in this meta-analysis, expressed the positive effect of tea consumption in reduced risk on oral cancer, especially in green tea(3).

Pterostilbene and Resveratrol are phytochemicals in the class of Stilbenoids, found abundantly in grapes, blueberries, etc.,... According to the joint study lead by the Rani Durgavati University, pterostilbene may be one of potential therapeutic compounds for treatment of oral cancer(4). In the extensive research of herbal medicines or natural foods during cancer therapy, the Chung Shan Medical University joint study confirmed that pterostilbene caused autophagy and apoptosis in human oral cancer cells via activation of JNK1/2, the T cell differentiation and the cellular apoptosis pathway(5)

Furthermore, the phytochemical also is found to suppress oral cancer cell invasion by inhibiting MMP-2 expression of metastasis(6).

Dr. Yu XD and colleagues at the joint study lead by the Shandong University, said, "resveratrol exhibits inhibitory effect on the proliferation of OSCC oral cancer cells through the induction of apoptosis and G2/M phase cell cycle arrest"(7).

Similarly to Pterostilbene, resveratrol also inhibited MMP-9 expression and oral cancer cell metastasis via down regulated JNK1/2 and ERK1/2(survival and apopotic) signals pathways(8).

The finding of the effectiveness of Green Tea, Blue berry and Grape may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Mouth (Oral) cancer

People who are at increased risk of  Mouth (Oral) cancer due to family history, weaken immunity,....should drink the juices at least one a day. People with Mouth (Oral) cancer should drink the juice as much as  as they can, depending to digestive toleration.

Life style and diet pattern change are recommended.

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis

By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) [Experimental study on anti-tumor effect and mechanism of green tea extract].[Article in Chinese] by Liu XL1, Liu HQ, Li J, Yang L, Zhao X.(PubMed)
(2) Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling by Tao L1, Park JY, Lambert JD.(PubMed)
(3) Association of tea consumption and the risk of oral cancer: a meta-analysis by Wang W1, Yang Y2, Zhang W3, Wu W4.(PubMed))
(4) Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine. by Bundela S1,2, Sharma A2, Bisen PS1,(PubMed)) 

(5) Pterostilbene induce autophagy on human oral cancer cells through modulation of Akt and mitogen-activated protein kinase pathway by Ko CP1, Lin CW2, Chen MK3, Yang SF4, Chiou HL5, Hsieh MJ6.(PubMed)

(6) Pterostilbene suppresses oral cancer cell invasion by inhibiting MMP-2 expression. by Lin CW1, Chou YE, Chiou HL, Chen MK, Yang WE, Hsieh MJ, Yang SF.(PubMed

(7) Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest. by Yu XD1,2,3, Yang JL4, Zhang WL2, Liu DX5,6.(PubMed)

(8) Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells by Lin FY1,2, Hsieh YH3, Yang SF1,4, Chen CT5,6, Tang CH7,8, Chou MY5,9, Chuang YT1, Lin CW6,9, Chen MK1,10.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Pneumonia Treatment In conventional medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                                      Pneumonia

Pneumonia is a condition of the inflammation of the lung as a result of infection, caused by bacteria, such as bacteria Streptococcus pneumoniae or influenza viruses in most cases. Fungi, such as Pneumocystis jiroveci, certain medication such as PPI Stomach Acid Drugs and other conditions such as impaired immune systems can also induced the disease.

                                Treatment

 In conventional medicine perspective
Antibiotics are the most effective medication used to treat pneumonia. Other medication used conjunction with antibiotics can be helpful in relieving breathing and symptoms.
1. Antibiotics
Pneumonia caused by bacterial pathogens is the leading cause of mortality in children in low-income countries. In a review to identify effective antibiotics for community acquired pneumonia (CAP) in children by comparing various antibiotics, conducted by All India Institute of Medical Sciences, Ansari Nagar, indicated that for treatment of ambulatory patients with CAP, amoxycillin is an alternative to co-trimoxazole. With limited data on other antibiotics, co-amoxyclavulanic acid and cefpodoxime may be alternative second-line drugs. For severe pneumonia without hypoxia, oral amoxycillin may be an alternative to injectable penicillin in hospitalised children; however, for ambulatory treatment of such patients with oral antibiotics, more studies in community settings are required. For children hospitalised with severe and very severe CAP, penicillin/ampicillin plus gentamycin is superior to chloramphenicol. The other alternative drugs for such patients are ceftrioxone, levofloxacin, co-amoxyclavulanic acid and cefuroxime. Until more studies are available, these can be used as a second-line therapy69).
Side effects are not limit to soft stools or diarrhea, mild stomach upset, etc.
2. Antivirals
Parainfluenza viruses affect the upper respiratory tract in all age group patients, in children aged 6 months to 3 years in particular. In the study to investigate the antiviral activity of Ingavirin (2-(imidazole-4-yl) ethanamide of pentandioic-1,5 acid) on a model of parainfluenza infection in Syrian hamsters, showed that the drug was shown to restrict the infectious process in animal lung tissue. This restriction manifested itself as reductions in the infectious titer of parainfluenza virus in the lung tissue, in the degree of pulmonary edema and tissue cell infiltration, and in virus-specific lesion of bronchial epithelial cells(70). Side effects are not limit to dizziness, fatigue, joint or muscle pain, headache, dry mouth, nausea, vomiting, loss of appetite, weight loss, insomnia, etc.
3. Other Supportive treatment to reduce symptoms, include
Fever and pain reducers such as aspirin, ibuprofen, naproxen or acetaminophen, etc. and cough medicine.

All Forms of Arthritis are Curable
You Can Eliminate OsteoarthritisBy addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(69) http://www.ncbi.nlm.nih.gov/pubmed/20238334
(70) http://www.ncbi.nlm.nih.gov/pubmed/22834146

The Powerful Smoothie of Green Tea, Blueberry and Grape for Reduced Risk and Treatment of Melasma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  melasma

Yield: 2 servings (about 8 ounces each)

3/4 cup blueberry
3/4 cup grape

1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of  melasma has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent study lead by renowned institutions conveyed that green tea(1) may be holding a key for extracting natural ingredient for reduced early onset and treatment of melasma. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the University of Minnesota, green tea polyphenols confer protective effects on the skin against ultraviolet (UV) irradiation-induced acceleration of skin aging, including pigmentation abnormalities such as melasma, freckles, senile lentigines, and other forms of melanin hyperpigmentation(1).

Melasma, is a common skin problem, causes of hyperpigmentation with brown to gray-brown patches on the face.

Glycolic Acid found abundantly in Blueberry and strawberry showed improvement in melasma on both sides of the face with tolerated adverse effects(2)
.Dr. Sharad J. Dr at the Skinfiniti Aesthetic Skin and Laser Clinic, said, "Glycolic acid peel is the most common alpha-hydroxy acid peel, also known as fruit peel. It is simple, inexpensive, and has no downtime. This review talks about various studies of glycolic acid peels for various indications, such as acne, acne scars, melasma, postinflammatory hyperpigmentation, photoaging, and seborrhea"(3).

The combination of glycolic acid peeling with topical regimen(2% hydroquinone, 1% hydrocortisone and 0.05% tretinoin) in patients of moderate to severe epidermal variety melasma is highly effective,
safe and promising therapeutic option in treatment of melasma(4).In dark-skinned patients with melasma, serial glycolic acid peels used combination with topical cream provide an additional effect in the treatment of melasma, according to the Government Medical College and Hospital(5).

The finding of the effectiveness of Green Tea, Grape and Blue Berry may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of  melasma.

People who are at increased risk of melasma due to family history,occupations,....should drink the juices at least one a day. People with melasmae should drink the juice as much as  as they can depending to digestive toleration.
Life style and diet pattern change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Molecular Mechanisms of Green Tea Polyphenols with Protective Effects against Skin Photoaging by Roh E1, Kim JE, Kwon JY, Park JS, Bode AM, Dong Z, Lee KW.(PubMed)

(2) Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. by Lim JT1.(PubMed)

(3) Glycolic acid peel therapy - a current review by Sharad J1.(PubMed)

(4) Efficacy of combination of glycolic acid peeling with topical regimen in treatment of melasma by Chaudhary S, Dayal S.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Pneumonia - The Diet

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                                      Pneumonia

Pneumonia is a condition of the inflammation of the lung as a result of infection, caused by bacteria, such as bacteria Streptococcus pneumoniae or influenza viruses in most cases. Fungi, such as Pneumocystis jiroveci, certain medication such as PPI Stomach Acid Drugs and other conditions such as impaired immune systems can also induced th  e disease.

                        Prevention

Diet to prevent pneumonia
1. Garlic
Garlic is the natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant and antiseptic properties. Garlic cooked is fine but it loses many of its health-giving powers.
There is a report of a case of a critically ill infant with severe multidrug-resistant Pseudomonas aeruginosa pneumonia and bacteremia who was treated with garlic and antibiotics after in vitro demonstration of a change in the resistance pattern via the disc diffusion method on garlic-treated Mueller Hinton agar. To our knowledge, this is the first report of therapeutic garlic use in a critically ill infant in the literature(56).
2. Green tea
In a population-based cohort study to examine the association between green tea consumption and death from pneumonia in humans, with follow-up from 1995 to 2006., showed that Over 12 y of follow-up, we documented 406 deaths from pneumonia. In women, the multivariate HRs of death from pneumonia that were associated with different frequencies of green tea consumption were 1.00 (reference) for <1 cup/d, 0.59 (95% CI: 0.36, 0.98) for 1-2 cups/d, 0.55 (95% CI: 0.33, 0.91) for 3-4 cups/d, and 0.53 (95% CI: 0.33, 0.83) for > or =5 cups/d, respectively (P for trend: 0.008). In men, no significant association was observed(52).
3. Turmeric
Curcumin derived from the rhizome of turmeric has been used for decades and it exhibits anti-inflammatory, anti-carcinogenic, immunomodulatory properties by downregulation of various inflammatory mediators,. according to the study by Panjab University, Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice(58).
4. Citrus fruits, berries
Klebsiella pneumoniae is a ubiquitous opportunistic pathogen that colonizes at the mucosal surfaces in humans and causes severe diseases. Many clinical strains of K. pneumoniae are highly resistant to antibiotics. In the study of flavonols galangin, myricetin, quercetin, and kaempferol, bearing different numbers of hydroxyl substituent on the aromatic rings, to test whethermay inhibit dNTP binding of the primary replicative DnaB helicase of K. pneumoniae (KpDnaB), an essential component of the cellular replication machinery critical for bacterial survival, found that these flavonol compounds may be used in the development of new antibiotics that target K. pneumoniae and other bacteria(59).
5. Etc.
All Forms of Arthritis are Curable
You Can Eliminate OsteoarthritisBy addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(56) http://www.ncbi.nlm.nih.gov/pubmed/21480783
(57) http://www.ncbi.nlm.nih.gov/pubmed/19625686
(58) http://www.ncbi.nlm.nih.gov/pubmed/20056776
(59) http://www.ncbi.nlm.nih.gov/pubmed/21210194

The Smoothie of Bell Pepper, Sweet potato and Pineapple for reduced Risk and Treatment of Irregular Menstruation

Kyle J. Norton(Scholar, Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced symptoms and treatment of irregular menstruation
Yield: 2 serving (about 8 ounce each)
1/4 cup bell pepper
3/4 cup sweet potato

1/2 cup pineapple
1 cup of rice milk

1. Place all ingradietns in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The dream of finding the natural ingredient for prevention and treatment of irregular menstruation without adverse effects in replacement of conventional medication has no through antioxidant t been abated. Some ingredients have to discard due to it can achieve the same potent results in human trials.

Recent studies suggested that pepper fruits (Capsicum annuum L.)(1), sweet potato(4) and pineapple(5) may have a potential and therapeutic value for reduced risk and treatment of cervical cancer probably due to theirs' phytochemicals effect in ameliorated proliferation of cancer cell expression.

Irregular menstruation or period is defined as condition in which a woman is experience abnormal variation of length of the menstrual cycle. While the normal menstrual cycle is 28-35 days, women who are experience with irregular menstrual cycle can have a length variation between 8 and 20 days or shorter than 21 days, or longer than 36 days

Phenolic acid glycossides found hot pepper fruits(1) and herbal medicine such as rhizomes of Polygonum paleaceum(2) exerted anti irregular menstruation effects through exhibition of free radical-scavenging activity(2). According to the Kunming Institute of Botany, Chinese Academy of Science, a new phenolic glycoside isolated from Balanophora involucrata HOOK.f. & THOMSON (Balanophoraceae), also displayed antioxidant properties in attenuated the expression of free radicals(3).

Vitamin E, best known for its powerful antioxidant property is a fat soluble vitamin found abundantly in sweet potato plays an essential role in regulation of normal menstrual period(4).Low serum vitamin E concentration is associated to irregular menstrual function in in athletes, according
to reported by Dr. Tomten SE Dr, Høstmark AT(4).

Melatonin, best known for its function in induced sleep, found abundantly in pineapples may also have an direct influence against irregular menstruation(5). According to the Yamaguchi University School of Medicine, abnormal plasma melatonin concentration in most of the women with an anovulatory cycle or amenorrhea was within the range of the mean level of +/- 1.5 x the standard deviation obtained from the 20 women with a regular menstrual cycle(5).

Dr.Miyauchi F and colleagues at the Ehime Rosai Hospital said, " The incidence (of irregular menstrual cycle)was significantly higher in women working at night than women working during the day" plasma concentrations of melatonin and prolactin at 0200 h were significantly lower in nurses of the working group than others of the resting group"(6).

The combination of Bell Pepper, Sweet potato and Pineapple smoothie may hold a key in further studies in production of an effective natural ingredients to reduce risk and treatment of irregular menstruation without inducing adverse effects.

Women who are at higher risk of irregular menstruation due to family history, obesity,...should take at least one serving daily. Women with irregular menstruation should drink as much as they can depending to the digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Isolation and structure elucidation of flavonoid and phenolic acid glycosides from pericarp of hot pepper fruit Capsicum annuum L. by Materska M1, Piacente S, Stochmal A, Pizza C, Oleszek W, Perucka I.(PubMed)

(2) Antioxidant phenolic compounds from rhizomes of Polygonum paleaceum.by Wang KJ1, Zhang YJ, Yang CR.(PubMed)

(3) A new phenolic constituent and a cyanogenic glycoside from Balanophora involucrata (Balanophoraceae) by She GM1, Zhang YJ, Yang CR.(PubMed)

(4) Serum vitamin E concentration and osmotic fragility in female long-distance runners by Tomten SE1, Høstmark AT.(PubMed)

(5) [Clinical significance of measurement of plasma melatonin concentration in women withirregular menstrual cycles].[Article in Japanese] by Miyauchi F1, Nakamura Y, Numa F, Kato H, Nanjo K, Otsuka K, Sasaki T, Yonezawa M, Tsukada Y.(PubMed)

(6) [Effects of night shift on plasma concentrations of melatonin, LH, FSH and prolactin, and menstrual irregularity].[Article in Japanese]by Miyauchi F1, Nanjo K, Otsuka K.(PubMed)

The Practical Smoothie of Orange and Wolfberry Juice and Honey with ot Without Low Fat Milk for Reduced Risk and Treatment of Chronic Cough

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Chronic Cough with no B12 deficiency
Yield: 2 servings (about 8 ounces each)
1/4 cup wolf berry
1/8 cup honey
1 3/4 cups orange juice

The smoothie for reduced risk and treatment of Chronic Cough with B12 deficiency
Yield: 2 servings (about 8 ounces each)
1/4 cup wolf berry
1/8 cup honey
3/4 cups orange juice

1 cup low fat milk

1. Place tall ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Chronic Cough without induced side effects has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.
Orange(1) and Wolfberry(4) Juice and Honey(6) with or without Low Fat Milk in recent studies by renowned institution suggested that the combined ingredients may consist a potential effect for production of natural alternation in treating respiratory disease, including cough.

Cough is a continued reflection and natural reaction of lung to clear the large breathing passages from secretions, irritants, foreign particles, etc. 

Chronic cough is a condition of coughing lasting more than eight weeks in adult and 4 weeks in children, affecting night time sleep caused by some underlying health problems, including astroesophageal reflux disease (GERD).

In conventional medicine, gabapentin and morphine are prescribed most frequently as top medication to treat and induced positive effects on cough-related quality of life, but only gabapentin was recommended(9).

In traditional Chinese medicine, the formula Nin Jiom Pei Pa Koa has shown effectively in treatment of chronic cough and other condition such as sore throat, coughs, hoarseness, and loss of voice. You can buy them in any Chinese herbal store about $7.00 CAN. According to the China Academy of Traditional Chinese Medicine, King To Nin Jiom Pei Pa Koa had significant cough relieving and sputum removing effects through its anti inflammaoty activties(10).

According to University of Turin, patients with unexplained chronic cough are associated to vitamin B12 deficiency(3), as the vitamin supplement significantly improved symptoms and laryngeal, bronchial, and cough thresholds in oral administration.

Vitamin C, also known as L-ascorbic acid, a water-soluble vitamin, found abundantly in orange juice, is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support in reduced risk of "morning cough", "chronic cough", "wheeze" and "wheeze ever(11).

According to the National Institute of Public Health and the Environment (RIVM), intake of vitamin C exhibited protective effects against respiratory symptoms in comparison to those with lower intake(2).

Dr.Goldman RD at the Canadian Paediatric Society, Drug Therapy and Hazardous Substances Committee, suggested, use of over counter medicine for treatment of cough in adult populations when cough frequency and severity, may cause medication errors and adverse events(3). Therefore, cough and cold therapies should consider intake of vitamin C and other forms of natural sources instead(3).

Wolfberry, also known as lycium fruits is the common name for the fruit of two very closely related species, the genus of Lycium, belongings to family Solanaceae, native to native to southeastern Europe and Asia. has been found effective in treatment of various human infectious diseases, including cough, according to the Hazara University Mansehra, Pakistan(4).


Dr. Cassileth B, professor at the Memorial Sloan-Kettering Cancer Center, said, " The berries of Lycium barbarum, a perennial plant native to Asia and southeastern Europe, have been used for centuries in traditional Chinese medicine to treat poor vision, anemia, inflammation, and cough"(6).
The fruit water extract also exhibited anti-inflammatory effect for treatment of cough through suppression of pro inflammatory cytokines(5).
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers, is considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people. Recently, it is considered as effective treatment of childhood cough, persistent post-infectious cough, according to the joint study lead by the Maastricht University Medical Center (MUMC)(7).

Dr. Ran D. Goldman, at the the College of Family Physicians of Canada said, "There is increasing evidence that a single dose of honey might reduce mucus secretion and reduce cough in children."(8).
In the study of honey for acute cough in children, Dr. Oduwole O and the research team at the University of Calabar Teaching Hospital (ITDR/P), insisted (without consideration of the adverse effect of conventional medicine of dextromethorphan) that honey may be better than 'no treatment' and diphenhydramine in the symptomatic relief of cough but not better than dextromethorphan(9).

Orange juice, containing the highest amount of vitamin C in comparison to other fruits may mimic the similar effects when use conjunction with wolf berry and honey for reduced risk and treatment of cough with no adverse effects.

People who are at increased risk of Chronic cough , due to family history, smoking,....should drink the juices at least one a day. People with Chronic cough should drink the juice as much as as they can depending to digestive toleration.
Life style and diet pattern change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Dietary vitamin C intake is inversely related to cough and wheeze in young smokers.Omenaas E1, Fluge O, Buist AS, Vollmer WM, Gulsvik A.(PubMed)
(2) Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN study by Grievink L1, Smit HA, Ocké MC, van 't Veer P, Kromhout D.(PubMed)
(3) Treating cough and cold: Guidance for caregivers of children and youth.[Article in English, French] by Goldman RD; Canadian Paediatric Society, Drug Therapy and Hazardous Substances Committee.(PubMed)
(4) Investigation of traditional medicinal floral knowledge of Sarban Hills, Abbottabad, KP, Pakistan. by Ijaz F1, Iqbal Z2, Rahman IU3, Alam J4, Khan SM5, Shah GM6, Khan K7, Afzal A8.(PubMed)
(5) Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells by Oh YC1, Cho WK, Im GY, Jeong YH, Hwang YH, Liang C, Ma JY.(PubMed)
(6) Lycium (Lycium barbarum) by Cassileth B1.(PubMed)
(7) Honey and Beehive Products in Otorhinolaryngology: a narrative review by Henatsch D1, Wesseling F1, Kross KW1, Stokroos RJ1.(PubMed)
(8) Honey for treatment of cough in children by Ran D. Goldman, MD FRCPC(PMC)

(9) Treatment of Unexplained Chronic Cough: CHEST Guideline and Expert Panel Report by Gibson P1, Wang G2, McGarvey L3, Vertigan AE4, Altman KW5, Birring SS6; CHEST Expert Cough Panel.(PubMed)
(10) [Pharmacological studies of nin jion pei pa koa].[Article in Chinese] by Li ZL1, Dai BQ, Liang AH, Li GQ, Yang Q, Xue BY.(PubMed)
(11) Unexplained chronic cough and vitamin B-12 deficiency by Bucca CB1, Culla B, Guida G, Sciascia S, Bellone G, Moretto A, Heffler E, Bugiani M, Rolla G, Brussino L.(PubMed)

The Best Smoothie of Green Tea, Blueberry and Grape for Reduced Early Onset and Treatment of Liver Diseases

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Liver disease
Yield: 2 servings (about 8 ounces each)
1 cup blueberry
1/2 cup grape
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  Liver disease   has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Liver disease or hepatic disease is defined as a condition of damage of liver or inflammatory causes of diseases to the liver.
Recent reports of study back by renowned institutions, conveyed that green tea(1) may be holding a key for extracting natural ingredient for reduced early onset and treatment of liver diseases.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the Saitama Cancer Center Research Institute,, regular intake of green tea drink is associated to protective effects against liver diseases(1).

In eight-week-old male C57BL/6J mice, fed a normal chow diet or high-fat diet (HFD) for 17 weeks, intake of pu-erh tea extract (PTE) ameliorated hepatic lipid metabolism, inflammation, and insulin resistance functions through by modulating hepatic IL-6/STAT3 signaling, the pro inflammatory pathway(2).

Dr. Yin X and colleagues at joint study lead by the Zhujiang Hospital of Southern Medical University, regardless of the race of the individual concerned where the Asian, American and European, green tea reduced risk of liver diseases, including hepatitis,hepatocellular carcinoma, liver steatosis, chronic liver disease,....(3).

Resveratrol, found abundantly in grape and blueberry,  is a plant-derived polyphenol with a potential as a food source to extend lifespan and healthspan in model organism. According to the University of Kansas Medical Center, the phytochemical exerted liver protective effects in xenobiotic-induced liver injury and other forms of liver injury(4). Also in acetaminophen hepatotoxicity causes of cause of acute liver injury and liver failure, resveratrol protected against Overdose of acetaminophen (APAP) hepatotoxicity through exhibiting antioxidant effects and preventing mitochondrial release of enzyme endonucleases and nuclear DNA damage(5).
Furthermore, the phytochemical may also be potential in reduced risk and treatment of liver fibrosis via the regulation of pro inflammatory, Akt/NF-κB pathways(6).

Pterostilbene, another antioxidant found in bluebrerry, used conjunction with resveratrol (RESV) expressed genotoxic and/or antigenotoxic effects through pro-apoptotic activity in HepG2 cells lines(7). Furthermore, pterostilbene also is potential against acetaminophen-induced hepatotoxicity(8), dimethylnitrosamine-induced liver fibrosis(9), plasma lipoproteins and cholesterol in hypercholesterolemic(10).

The finding of the effectiveness of Green Tea, Grape and Blue Berry may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of  Liver disease.

People who are at increased risk of  Liver disease, due to family history, alcohol drinking,....should drink the juices at least one a day. People with  Liver disease should drink the juice as much as  as they can depending to digestive toleration.
Life style and diet pattern change are recommended.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases by Imai K1, Nakachi K.(PubMed)

(2) Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice by Cai X1,2,3, Fang C2,4, Hayashi S2,3, Hao S5, Zhao M6, Tsutsui H2,3, Nishiguchi S7, Sheng J8.(PubMed)

(3) The effect of green tea intake on risk of liver disease: a meta analysis by Yin X1, Yang J2, Li T3, Song L4, Han T5, Yang M1, Liao H1, He J1, Zhong X1.(PubMed)

(4) Critical review of resveratrol in xenobiotic-induced hepatotoxicity by McGill MR1, Du K2, Weemhoff JL2, Jaeschke H2.(PubMed)

(5) Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity by Du K1, McGill MR1, Xie Y1, Bajt ML1, Jaeschke H2.(PubMed)

(6) Resveratrol attenuates the progress of liver fibrosis via the Akt/nuclear factor-κB pathways by Zhang H1, Sun Q1, Xu T1, Hong L1, Fu R1, Wu J1, Ding J1.(PubMed)

(7) In Vitro Safety/Protection Assessment of Resveratrol and Pterostilbene in a Human Hepatoma Cell Line (HepG2) by Lombardi G, Vannini S, Blasi F, Marcotullio MC, Dominici L, Villarini M, Cossignani L, Moretti M(PubMed)

(8) Protective effects of pterostilbene against acetaminophen-induced hepatotoxicity in rats by El-Sayed el-SM1, Mansour AM, Nady ME.(PubMed)

(9) Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats by Lee MF1, Liu ML, Cheng AC, Tsai ML, Ho CT, Liou WS, Pan MH.(PubMed)

(10) Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters by Rimando AM1, Nagmani R, Feller DR, Yokoyama W.(PubMed)