The Smoothie of Green Tea, Grape and Cabbage for Prevention and Treatment of Thyroid Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Thyroid Cancer
Yield: 2 servings (about 8 ounces each)
1 cup grape
1/2 cabbage
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  Thyroid Cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Thyroid cancer is defined as condition in which the cells in the thyroid gland have become cancerous.

Recent studies back by renowned institutions, conveyed that green tea(3) may be holding a key for extracting natural ingredient for reduced early onset and treatment of Thyroid Cancer.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and  health effects, green tea now has been cultivated all over the world in suitable climate. According to the Zhangqiu People's Hospital Ji'nan, higher tea consumption may have a protective effect on thyroid cancer, especially in Europe and America(1).
Epigallocatechin-3-gallate (EGCG), a major catechin in green tea, inhibited thyroid cancer cell proliferation and motility in associated to the loss of the initiation of metastasis for cancer progression(2) and to the suppression of EGFR/ERK pathway in binding to the receptor on the cell surface and cyclin B1/CDK1 complex for cell division(3).

Indole-3-carbinol is a phytochemical in the class of Indoles, found abundantly in cruciferous vegetables such as cabbage, kale, brussels sprouts, etc.... its acid catalyzed dimer 3,3'-diindolylmethane (DIM).exhibited anti proliferative effects in glandular thyroid proliferative disease(4).

The acid catalyzed dimer derivative processed anti-estrogen effects may be used as a part of therapeutic regimen to treat thyroid cancer, the New York Medical College suggested(5).

Futhermore, through its anti estrogenic effect and enhanced estrogen metabolism, 3,3'-diindolylmethane (DIM), can potentially serve as an antiestrogenic dietary supplement to help reduce the risk of developing thyroid proliferative disease (TPD)(6).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in blueberry and grape may also processed anti.Thyroid Cancer activity. Accoridng to the Hallym University College of Medicine, Polyphenol phytochemicals (PPs) in fruits and vegetables such as resveratrol inhibited cancer initiation, promotion, progression and induced redifferentiation, including thyroid cancer cell lines, TPC-1, FTC-133, NPA, FRO, and ARO(7).

Dr. Duntas LH said, "resveratrol may arrest, among various tumors, cell growth in both papillary and follicular thyroid cancer ' Prabably through inhibited pro inflammatory cytokines and activation of tumor antigen(8).

The School of Medicine-Timone study insisted that exhibits several beneficial health effects by its antioxidhant, antiinflammatory, and chemopreventive properties, including induced iodide trapping and efflux in FRTL-5 thyroid cancer cell line(9).

The finding of the effectiveness of Green Tea, Grape and Cabbage may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of  Liver cancer 

People who are at increased risk of Thyroid Cancer, due to family history, auto immunity,....should drink the juices at least one a day. People with Thyroid Cancer should drink the juice as much as  as they can depending to digestive toleration.

Life style and diet pattern change are recommended.

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis

By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Association of tea consumption and the risk of thyroid cancer: a meta-analysis by Ma S1, Wang C2, Bai J1, Wang X1, Li C3.(PubMed)
(2) Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in humanthyroid carcinoma cell lines by De Amicis F1, Perri A, Vizza D, Russo A, Panno ML, Bonofiglio D, Giordano C, Mauro L, Aquila S, Tramontano D, Andò S.(PubMed)
(3) Epigallocatechin-3-gallate induces growth inhibition and apoptosis of human anaplastic thyroidcarcinoma cells through suppression of EGFR/ERK pathway and cyclin B1/CDK1 complex by Lim YC1, Cha YY.(PubMed)
(4) 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound inthyroid disease by Tadi K1, Chang Y, Ashok BT, Chen Y, Moscatello A, Schaefer SD, Schantz SP, Policastro AJ, Geliebter J, Tiwari RK(PubMed)
(5) 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound inthyroid disease by Tadi K1, Chang Y, Ashok BT, Chen Y, Moscatello A, Schaefer SD, Schantz SP, Policastro AJ, Geliebter J, Tiwari RK.(PubMed)
(6) 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferativedisease: a pilot study by Rajoria S1, Suriano R, Parmar PS, Wilson YL, Megwalu U, Moscatello A, Bradlow HL, Sepkovic DW, Geliebter J, Schantz SP, Tiwari RK.(PubMed)
(7) Antiproliferation and redifferentiation in thyroid cancer cell lines by polyphenol phytochemicals. by Kang HJ1, Youn YK, Hong MK, Kim LS.(PubMed)
(8) Resveratrol and its impact on aging and thyroid function by Duntas LH1.(PubMed)
(9) Resveratrol increases iodide trapping in the rat thyroid cell line FRTL-5 by Sebai H1, Hovsépian S, Ristorcelli E, Aouani E, Lombardo D, Fayet G.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Pneumonia Treatment In herbal medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                                      Pneumonia

Pneumonia is a condition of the inflammation of the lung as a result of infection, caused by bacteria, such as bacteria Streptococcus pneumoniae or influenza viruses in most cases. Fungi, such as Pneumocystis jiroveci, certain medication such as PPI Stomach Acid Drugs and other conditions such as impaired immune systems can also induced the disease.

                                    Treatment

 In traditional Herbal medicine perspective

1. Crotalaria lachnophora
According to the study by University of Dschang, the 2 new isopropenyl-dihydrofuranoisoflavones, 7,2′,4′-trihydroxy-5”-isopropenyl-4”,5”-dihydrofurano[2'',3'':5,6]isoflavone (1) isolated exhibiting antimicrobial properties have been isolated along with eight known compounds from the Cameroonian medicinal plant Crotalaria lachnophora, showed moderate inhibitory activities against Escherichia coli and Klebsiella pneumoniae(71).

2. Uraria picta
Two isoflavanones, 5,7-dihydroxy-2′-methoxy-3′,4′-methylenedioxyisoflavanone (2) and 4′,5-dihydroxy-2′,3′-dimethoxy-7-(5- hydroxyoxychromen-7yl)-isoflavanone (4) along with six known compounds including isoflavanones, triterpenes and steroids isolated from the roots of Uraria picta, showed the minimum inhibitory concentrations (MIC) found to be in the range of 12.5-200 microg/ml against bacteria (both Gram positive and Gram negative) and fungi(72).

3. Vitex agnus-castus
A new compound, 6a,11a-dihydro-6H-[1] benzofuro [3,2-c][1,3]dioxolo[4,5-g]chromen-9-ol was isolated from the ethyl acetate fraction of Vitex agnus-castus. The structure of this compound was identified with the help of spectroscopic techniques ((13)C NMR, (1)H NMR, HMBC, HMQC, NOESY and COSY). The compound showed low urease- (32.0%) and chymotrypsin- (31.4%) inhibitory activity, and moderate (41.3%) anti-inflammatory activitym, according to the Center for Biotechnology and Microbiology University of Peshawar(73).

4. Fadogia ancylantha
Communities in Chilumba, Malawi use herbal tea prepared from Fadogia ancylantha Schweinf (Rubiaceae) leaves for the management of diabetes, hypertension and alleviation of symptoms of gastrointestinal disorders and pneumonia. In the study to evaluate the in vitro antidiabetic, anti-oxidant and antimicrobial activities of the crude extracts of the leaves prepared by using three different extraction methods, found that the organic extract (12.5μg/ml) exhibited the highest in vitro glucose uptake increases in Chang cells (181.24±0.29%) and C2C12 muscle cells (172.29±0.32%) while the hot and cold aqueous extracts gave lower uptakes, 145.94±0.37% and 138.70±0.52% in Chang cells respectively. At 100μg/ml, aqueous extracts gave significantly higher (p<0.01) anti-oxidant activity (range 85.78-86.29%) than their organic counterpart (68.16%). The minimum inhibitory concentration (156μg/ml) was obtained in the organic extract against the fungus Aspergillus fumigatus and moderate growth inhibition was observed with other test micro-organisms. The hot aqueous extract inhibited the growth of all test organisms except Pseudomonas aeruginosa. The cold aqueous extract was inactive against Pseudomonas aeruginosa and Candida albicans. The differences in the MIC values between the aqueous extracts seem to suggest that raised temperatures, as traditionally practised, facilitate the extraction of secondary bioactive metabolites(74).

All Forms of Arthritis are Curable
You Can Eliminate OsteoarthritisBy addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(71) http://www.ncbi.nlm.nih.gov/pubmed/21265557
(72) http://www.ncbi.nlm.nih.gov/pubmed/17540419
(73) http://www.ncbi.nlm.nih.gov/pubmed/21058321
(74) http://www.ncbi.nlm.nih.gov/pubmed/22800680

The delicious smoothie of Green Tea, Grape and Curcumin in Prevention and Treatment of Testicular Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Testicular Cancer
Yield: 2 servings (about 8 ounces each)
1 1/2 cup grape
1/2 tsp curcumin
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  Testicular Cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Testicular Cancer is a cancer arises in the testicles (testes), which are located inside the scrotum, part of male reproductive system, responding to the production and reproduction of male sex hormones and sperm. It tends to develop in the age groups of twenties and thirties.

Recent studies back by renowned institutions, conveyed that Green Tea(3), Grape(4) and Curcumin (6)may be holding a key for extracting natural ingredient for reduced early onset and treatment of Testicular Cancer.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the joint study lead by the University of Rajasthan, green tea extract exhibited the restoring of testicular injuries induced by CdCl2 intoxication in mammals, through significantly increased testicular antioxidant enzymatic activities(1).
Nutrient mixture (NM) containing lysine, proline, arginine, ascorbic acid, and green tea extract significantly inhibited MMP secretion and matrix invasion in testicular cancer cells without toxic effect in a dose-dependent fashion(2).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry may also be an candidate in production of effective ingredient for prevention and treatment of testicular cancer(4). According to the Minia University, resveratrol promoted methotrexate (MTX) tumor cytotoxicity, while protecting the testes, probably via up-regulation of testicular Mrp3 as a novel mechanism(3).

Furthermore, the Chinese herbal drugs resveratrol, lycium barbarum polysaccharide (LBP) and icariin exhibited almost complete recovery from reproductive endocrine disorder and spermatogenic damage.on 60Co-gamma-induced spermatogenic disturbance in mice(5).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. Its antioxidant curcumin may be the best agent for prevention and treatment of Testicular Cancer through its effects on gland weights, testicular testosterone concentrations, and spermatogenesis on animal model(6).

According to the kdeniz University, use of curcumin together with bleomycin not only induce apoptosis in testicular cancer cells, but also decreased ibleomycin therapeutic dose in reduced less adverse effects(7).The Akdeniz University study suggested that through its antioxidant effects, curcumin also inhibited bleomycin, a commonly used in the treatment of testicular cancer and H2O2-induced oxidative stress in human testicular cancer cells(8).

The finding of the effectiveness of Green Tea, Grape and Curcumin may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of  Liver cancer 

People who are at increased risk of Testicular Cancer, due to family history, auto immunity,....should drink the juices at least one a day. People with Testicular Cancer  should drink the juice as much as  as they can depending to digestive toleration.

Life style and diet pattern change are recommended.

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis

By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Ameliorative Effect of Green Tea Catechin Against Cadmium Chloride-Induced Testicular Toxicity in Mice by Sharma P1, Goyal PK2.(PubMed)

(2) Inhibitory effects of a nutrient mixture on human testicular cancer cell line NT 2/DT matrigel invasion and MMP activity by Roomi MW1, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M.(PubMed)

(3) Multi-drug resistance protein (Mrp) 3 may be involved in resveratrol protection against methotrexate-inducedtesticular damage by El-Sheikh AA1, Morsy MA2, Al-Taher AY3.(PubMed)

(4) Effects of resveratrol on methotrexate-induced testicular damage in rats by Yuluğ E1, Türedi S, Alver A, Türedi S, Kahraman C.(PubMed)

(5) [Chinese medicinal monomer and compound for 60Co-gamma-induced spermatogenic disturbance in mice].[Article in Chinese]by Zhang WX1, Wang HL, Wang R, Li R, He W, Zhang TB.(PubMed)

(6) Reproductive effects of a pegylated curcumin by Murphy CJ1, Tang H, Van Kirk EA, Shen Y, Murdoch WJ.(PubMed)

(7) Synergistic anticancer activity of curcumin and bleomycin: an in vitro study using human malignant testiculargerm cells. by Cort A1, Timur M, Ozdemir E, Kucuksayan E, Ozben T.(PubMed)

(8) Effects of curcumin on bleomycin‑induced oxidative stress in malignant testicular germ cell tumors by Cort A1, Ozdemir E, Timur M, Ozben T.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Pneumonia Treatment In traditional Chinese medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                                      Pneumonia

Pneumonia is a condition of the inflammation of the lung as a result of infection, caused by bacteria, such as bacteria Streptococcus pneumoniae or influenza viruses in most cases. Fungi, such as Pneumocystis jiroveci, certain medication such as PPI Stomach Acid Drugs and other conditions such as impaired immune systems can also induced the disease.

                                    Treatment

 In traditional Chinese medicine perspective
According to the study by Gansu College of Traditional Chinese Medicine in TCM differentiation of the symptoms and signs, 52 children with presisting pneumonia were divided into the following four types: 1) deficiency of body fluid due to accumulation of heat in the lung, 2) earth failing to generate metal, 3) deficiency of the Ying and Wei systems, and 4)excessiveness of pathogens due to qi deficiency. After treatment for 2-3 weeks, 40-cases were cured, 8 improved, and 4 ineffective(75).
Other in the study to observe the therapeutic effect of traditional Chinese medicine (TCM) and Western medicine (WM) treatments on mycoplasmal pneumonia in children and the changes in the serum cytokines, showed that the total response rate was 93.33% in the treatment group and 73.33% in the control group, showing a significantly better therapeutic effect in the treatment group (P<0.05). The combined treatments also showed better effects in alleviating fever, coughing and rales (P<0.05), and resulted in more obvious reduction in the serum levels of cytokines (P<0.05)(76)
In the study to probe into the mechanism on TCM treatment of infectious atypical pneumonia (severe acute respiratory syndrome, SARS) and evaluate its feasibility and effectiveness in 12 TCM prescriptions of herbal drugs (orally or i.v.) used to treat 16 cases of SARS without using glucocorticoids, anti-viral agents, immune-regulators or antibiotics (in case there was no definite bacterial infections) found that The average fever abatement time was 4.44 +/- 1.46 days and the mean absorption time of gross pulmonary infiltration was 10.87 +/- 2.92 days. No exacerbation occurred during the treatment(77).
1. Qingfei Huatan Quyu method
In the study to observe the therapeutic effect of Qingfei Huatan Quyu method (QHQ, a Chinese medicinal therapy for clearing Fei-heat and dissolving phlegm-stasis) combined with hormone-antibiotic therapy (HAT) on radiation pneumonia (RP), found that QHQ combined with HAT has a definite therapeutic effect on RP. It could efficiently decrease the plasma levels of IL-6 and TGF-beta in patients with RP(78).
2. Qingjin Runfei Decoction
In the study of Patients randomly assigned to two groups, the control group (51 cases) treated with hormone and antibiotic and the treated group (53 cases) with the above therapy plus QRD conducted by Hangzhou Hospital of Armed Police in Zheijang, found that QRD could enhance the effects of hormone and antibiotic in treating RP, as well as improve QOL of the patients(79).
3. Etc.

All Forms of Arthritis are Curable
You Can Eliminate OsteoarthritisBy addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(75) http://www.ncbi.nlm.nih.gov/pubmed/10453606
(76) http://www.ncbi.nlm.nih.gov/pubmed/20335158
(77) http://www.ncbi.nlm.nih.gov/pubmed/15688692
(78) http://www.ncbi.nlm.nih.gov/pubmed/18672767
(79) http://www.ncbi.nlm.nih.gov/pubmed/17432692

The Smoothie of Green Tea, Blueberry and Grape for Prevention and Treatment of Mouth (Oral) cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Mouth (Oral) cancer
Yield: 2 serving (about 8 ounce each)
3/4 cup blueberry
3/4 cup grape
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  Lichen planus has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by renowned institutions, conveyed that green tea(3) may be holding a key for extracting natural ingredient for reduced early onset and treatment of Mouth (Oral) cancer.

Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the First Hospital of Jilin University, green tea extract (GTE) inhibited three human oral squamous carcinoma
cell lines (CAL-27, SCC-25 and KB), through cell cycle arrest in S and G2/M phases(1).Green tea polyphenol, (-)-epigallocatechin-3-gallate, another major phytochemical, not only can induce oxidative stress in oral cancer cells but exerts antioxidant effects in normal cells(2).
Furthermore, in 14 articles with 19 studies comprising 4675 oral cancer cases were included in this meta-analysis, expressed the positive effect of tea consumption in reduced risk on oral cancer, especially in green tea(3).

Pterostilbene and Resveratrol are phytochemicals in the class of Stilbenoids, found abundantly in grapes, blueberries, etc.,... According to the joint study lead by the Rani Durgavati University, pterostilbene may be one of potential therapeutic compounds for treatment of oral cancer(4). In the extensive research of herbal medicines or natural foods during cancer therapy, the Chung Shan Medical University joint study confirmed that pterostilbene caused autophagy and apoptosis in human oral cancer cells via activation of JNK1/2, the T cell differentiation and the cellular apoptosis pathway(5)

Furthermore, the phytochemical also is found to suppress oral cancer cell invasion by inhibiting MMP-2 expression of metastasis(6).

Dr. Yu XD and colleagues at the joint study lead by the Shandong University, said, "resveratrol exhibits inhibitory effect on the proliferation of OSCC oral cancer cells through the induction of apoptosis and G2/M phase cell cycle arrest"(7).

Similarly to Pterostilbene, resveratrol also inhibited MMP-9 expression and oral cancer cell metastasis via down regulated JNK1/2 and ERK1/2(survival and apopotic) signals pathways(8).

The finding of the effectiveness of Green Tea, Blue berry and Grape may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Mouth (Oral) cancer

People who are at increased risk of  Mouth (Oral) cancer due to family history, weaken immunity,....should drink the juices at least one a day. People with Mouth (Oral) cancer should drink the juice as much as  as they can, depending to digestive toleration.

Life style and diet pattern change are recommended.

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis

By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) [Experimental study on anti-tumor effect and mechanism of green tea extract].[Article in Chinese] by Liu XL1, Liu HQ, Li J, Yang L, Zhao X.(PubMed)
(2) Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling by Tao L1, Park JY, Lambert JD.(PubMed)
(3) Association of tea consumption and the risk of oral cancer: a meta-analysis by Wang W1, Yang Y2, Zhang W3, Wu W4.(PubMed))
(4) Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine. by Bundela S1,2, Sharma A2, Bisen PS1,(PubMed)) 

(5) Pterostilbene induce autophagy on human oral cancer cells through modulation of Akt and mitogen-activated protein kinase pathway by Ko CP1, Lin CW2, Chen MK3, Yang SF4, Chiou HL5, Hsieh MJ6.(PubMed)

(6) Pterostilbene suppresses oral cancer cell invasion by inhibiting MMP-2 expression. by Lin CW1, Chou YE, Chiou HL, Chen MK, Yang WE, Hsieh MJ, Yang SF.(PubMed

(7) Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest. by Yu XD1,2,3, Yang JL4, Zhang WL2, Liu DX5,6.(PubMed)

(8) Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells by Lin FY1,2, Hsieh YH3, Yang SF1,4, Chen CT5,6, Tang CH7,8, Chou MY5,9, Chuang YT1, Lin CW6,9, Chen MK1,10.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Pneumonia Treatment In conventional medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                                      Pneumonia

Pneumonia is a condition of the inflammation of the lung as a result of infection, caused by bacteria, such as bacteria Streptococcus pneumoniae or influenza viruses in most cases. Fungi, such as Pneumocystis jiroveci, certain medication such as PPI Stomach Acid Drugs and other conditions such as impaired immune systems can also induced the disease.

                                Treatment

 In conventional medicine perspective
Antibiotics are the most effective medication used to treat pneumonia. Other medication used conjunction with antibiotics can be helpful in relieving breathing and symptoms.
1. Antibiotics
Pneumonia caused by bacterial pathogens is the leading cause of mortality in children in low-income countries. In a review to identify effective antibiotics for community acquired pneumonia (CAP) in children by comparing various antibiotics, conducted by All India Institute of Medical Sciences, Ansari Nagar, indicated that for treatment of ambulatory patients with CAP, amoxycillin is an alternative to co-trimoxazole. With limited data on other antibiotics, co-amoxyclavulanic acid and cefpodoxime may be alternative second-line drugs. For severe pneumonia without hypoxia, oral amoxycillin may be an alternative to injectable penicillin in hospitalised children; however, for ambulatory treatment of such patients with oral antibiotics, more studies in community settings are required. For children hospitalised with severe and very severe CAP, penicillin/ampicillin plus gentamycin is superior to chloramphenicol. The other alternative drugs for such patients are ceftrioxone, levofloxacin, co-amoxyclavulanic acid and cefuroxime. Until more studies are available, these can be used as a second-line therapy69).
Side effects are not limit to soft stools or diarrhea, mild stomach upset, etc.
2. Antivirals
Parainfluenza viruses affect the upper respiratory tract in all age group patients, in children aged 6 months to 3 years in particular. In the study to investigate the antiviral activity of Ingavirin (2-(imidazole-4-yl) ethanamide of pentandioic-1,5 acid) on a model of parainfluenza infection in Syrian hamsters, showed that the drug was shown to restrict the infectious process in animal lung tissue. This restriction manifested itself as reductions in the infectious titer of parainfluenza virus in the lung tissue, in the degree of pulmonary edema and tissue cell infiltration, and in virus-specific lesion of bronchial epithelial cells(70). Side effects are not limit to dizziness, fatigue, joint or muscle pain, headache, dry mouth, nausea, vomiting, loss of appetite, weight loss, insomnia, etc.
3. Other Supportive treatment to reduce symptoms, include
Fever and pain reducers such as aspirin, ibuprofen, naproxen or acetaminophen, etc. and cough medicine.

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Sources
(69) http://www.ncbi.nlm.nih.gov/pubmed/20238334
(70) http://www.ncbi.nlm.nih.gov/pubmed/22834146

The Powerful Smoothie of Green Tea, Blueberry and Grape for Reduced Risk and Treatment of Melasma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  melasma

Yield: 2 servings (about 8 ounces each)

3/4 cup blueberry
3/4 cup grape

1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of  melasma has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent study lead by renowned institutions conveyed that green tea(1) may be holding a key for extracting natural ingredient for reduced early onset and treatment of melasma. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the University of Minnesota, green tea polyphenols confer protective effects on the skin against ultraviolet (UV) irradiation-induced acceleration of skin aging, including pigmentation abnormalities such as melasma, freckles, senile lentigines, and other forms of melanin hyperpigmentation(1).

Melasma, is a common skin problem, causes of hyperpigmentation with brown to gray-brown patches on the face.

Glycolic Acid found abundantly in Blueberry and strawberry showed improvement in melasma on both sides of the face with tolerated adverse effects(2)
.Dr. Sharad J. Dr at the Skinfiniti Aesthetic Skin and Laser Clinic, said, "Glycolic acid peel is the most common alpha-hydroxy acid peel, also known as fruit peel. It is simple, inexpensive, and has no downtime. This review talks about various studies of glycolic acid peels for various indications, such as acne, acne scars, melasma, postinflammatory hyperpigmentation, photoaging, and seborrhea"(3).

The combination of glycolic acid peeling with topical regimen(2% hydroquinone, 1% hydrocortisone and 0.05% tretinoin) in patients of moderate to severe epidermal variety melasma is highly effective,
safe and promising therapeutic option in treatment of melasma(4).In dark-skinned patients with melasma, serial glycolic acid peels used combination with topical cream provide an additional effect in the treatment of melasma, according to the Government Medical College and Hospital(5).

The finding of the effectiveness of Green Tea, Grape and Blue Berry may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of  melasma.

People who are at increased risk of melasma due to family history,occupations,....should drink the juices at least one a day. People with melasmae should drink the juice as much as  as they can depending to digestive toleration.
Life style and diet pattern change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Molecular Mechanisms of Green Tea Polyphenols with Protective Effects against Skin Photoaging by Roh E1, Kim JE, Kwon JY, Park JS, Bode AM, Dong Z, Lee KW.(PubMed)

(2) Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. by Lim JT1.(PubMed)

(3) Glycolic acid peel therapy - a current review by Sharad J1.(PubMed)

(4) Efficacy of combination of glycolic acid peeling with topical regimen in treatment of melasma by Chaudhary S, Dayal S.(PubMed)