Saturday, March 26, 2016

The Smoothie of formula RRF and Flax Seed for Reduced Symptoms of Perimenopause

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced symptoms and treatment of Perimenopause 
Yield: 2 serving (about 8 ounce each)
1 gram of formula RRF(you cam buy them in any Chinese herbal store)
1/2 cup of flax seed
1 cup of grape
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for reduced symptoms and treatment of Perimenopause  is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine.
Unfortunately, many compounds found effective in initial studying failed to confirm the potentials in large sample size and multi center.

Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, from Radix Astragali (RA), Radix Angelicae Sinensis (RAS) and Folium Epimedii (FE), three of the extensively applied herbs among traditional Chinese medicines for gynecological disorders(1), including symptoms of Perimenopause.

Long-term treatment of RRF formula exhibited estrogenic properties, inhibited age-associated egeneration may be considered as an alternative/complementary medicine in relieving perimenopausal symptoms(1), according to the joint study lead by the Guangzhou University of Chinese Medicine.

Huang Qi or Bei Qi is also known as Astragalus root. The sweet herb has been used as diuretic agent and to lower blood pressure, increase blood pressure, lessens proteinuria, improve endurance, protect liver function, regulate blood sugar, etc.

In natural aging animal study, Radix Astragali used conjuction with Radix Angelicae Sinensis, and Folium Epimedii in formula RRF, expressed a a positive regulation on the estrogen imbalance and neurotransmitter disorder in restoring reproductive organ degeneration and skeleton deterioration in perimenopausal rats(2).

According to the Guangzhou University Town, RRF also enhanced estradiol (E(2) synthese while diminished the elevated serum FSH and LH levels, attenuated osteoporosis by elevating the BMD levels of total body and bone trabeculae degradation of which induced a capable of acting at multiple targets in the protection and treatment of perimenopausal disorders in midlife women(3).

Furthermore, RRF on study of immunological function, RRF also displayed a relatively wide margin of safety. Dr. Xie JH and colleagues at the joint study lead by the Guangzhou University of Chinese Medicine, Guangzhou said, "Long-term treatment of RRF exhibited estrogenic properties, and retarded certain age-associated degenerations" and "RRF might have the potential for further development as a safe and effective alternative/complementary to conventional medication in relieving perimenopausal symptoms."(4).

On Chinese medicinal plant Radix astragali(RA) alone in the study of 24 ovariectomized female Sprague-Dawley (SD) rats, oral application of RA significantly improved the immune functions of the ovariectomized female rats, but cannot induced the change the sex hormones levels as significantly as estrogen(5).

Dang Qui (Angelica sinensis) is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. Use conjunction with Radix Astragali and Folium Epimedii in formula RRF improved the aging degeneration of perimenopausal symptoms in animal study(2).

Folium Epimedii, deciduous or evergreen hardy perennials, native to Asia, and a few in the Mediterranean region has been used in Chinese medicine for induced sexual activity. When used together with Dang qui and Huang qi in formula RRF has shown effectively in enhanced the balancing of diminished hormones due to aging in reduced the expression of perimenopausal symptoms(3).

In take of phytoestrogen with function as weak estrogens, antioxidants, and anti-inflammatory agents(6) plant based lignans, a chemical compoud found in flax seed, may be effective in ameliorated symptoms of peri menopause, according to the joint study lead University of Zurich(7),

The combination of formula RRF and Flax Seed  smoothie may hold a key in further studies in production of an effective natural ingredients for reduced the symptoms displacement and treatment of perimenopause without inducing adverse effects.

Women who are in the perimenopause stage should drink as much as they can, depending to the digestive toleration.



References
(1) Evaluation of safety of Modified-Danggui Buxue Tang in rodents: Immunological, toxicity and hormonal aspects by Xie JH1, Chen ZW2, Pan YW3, Luo DM3, Su ZR4, Chen HM1, Qin Z5, Huang SQ6, Lei G7.(PubMed)
(2) Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: An In Vivo Study on Natural Aging Rat Model by Su JY1, Xie QF2, Liu WJ1, Lai P1, Liu DD1, Tang LH1, Dong TT3, Su ZR4, Tsim KW3, Lai XP4, Li KY5.(PubMed)
(3) Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats by Xie QF1, Xie JH, Dong TT, Su JY, Cai DK, Chen JP, Liu LF, Li YC, Lai XP, Tsim KW, Su ZR.(PubMed)
(4) Evaluation of safety of Modified-Danggui Buxue Tang in rodents: Immunological, toxicity and hormonal aspects by Xie JH1, Chen ZW2, Pan YW3, Luo DM3, Su ZR4, Chen HM1, Qin Z5, Huang SQ6, Lei G7.(PubMed)
(5) Effects of a Chinese medicinal plant Radix astragali on the ovariectomized female rats by Zheng Y1, Jin Y, Zhu HB, Xu ST, Xia YX, Huang Y.(PubMed)
(6) Urinary phytoestrogen levels and frailty in older American women of the National Health and Nutrition Examination Survey (NHANES) 1999-2002: a cross-sectional study by Eichholzer M1, Richard A, Walser-Domjan E, Linseisen J, Rohrmann S.(PubMed)
(7)  Urinary phytoestrogens and depression in perimenopausal US women: NHANES 2005-2008. by Richard A1, Rohrmann S2, Mohler-Kuo M3, Rodgers S4, Moffat R5, Güth U6, Eichholzer M2.(PubMed)
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Most Common Diseases of elder: Respiratory Pleural disease: Pleural effusion Treatments in Herbal medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                   Pleural disease: Pleural effusion

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural effusion is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.

                     The Treatment



Treatments in Herbal medicine perspective
1. Cordia verbenacea
In the study to evaluate the anti-inflammatory and anti-allergic effects of the essential oil of Cordia verbenacea (Boraginaceae) and some of its active compounds, indicated that treatment with the essential oil of Cordia verbenacea (300-600mg/kg, p.o.) reduced carrageenan-induced rat paw oedema, myeloperoxidase activity and the mouse oedema elicited by carrageenan, bradykinin, substance P, histamine and platelet-activating factor. It also prevented carrageenan-evoked exudation and the neutrophil influx to the rat pleura and the neutrophil migration into carrageenan-stimulated mouse air pouches(105).

2. Taraxacum
The genus Taraxacum is a member of the family Asteraceae, subfamily Cichorioideae, tribe Lactuceae and widely distributed in the warmer temperate zones of the Northern Hemisphere. pharmacologically relevant compounds of Taraxacum characterized so far and of the studies support of its use as a medicinal plant. Particular attention has been given to diuretic, choleretic, anti-inflammatory, anti-oxidative, anti-carcinogenic, analgesic, anti-hyperglycemic, anti-coagulatory and prebiotic effects(106).

3. Scutellaria baicalensis, Coptis japonica, Curcuma longa and Poncirus trifoliata
Baicalein, berberine, curcumin and hesperidin are the major components derived from Scutellaria baicalensis, Coptis japonica, Curcuma longa and Poncirus trifoliata, respectively. According to the study by the Chungnam National University, berberine, curcumin and hesperidin can increase mucin release by directly acting on airway mucin-secreting cells and suggest that these agents be further studied for possible use as mild expectorants during the treatment of chronic airway diseases(107).

4. Scutellaria baicalensis Georgi
Scutellaria baicalensis Georgi has been used for the treatment of diverse chronic inflammatory diseases including respiratory disease in oriental medicine and its major components, baicalin, baicalein and wogonin – were reported to have various biological effects. According to the study by the Chungnam National University,baicalin and wogonin can slightly increase basal mucin release whereas they can inhibit ATP-induced mucin release, by directly acting on airway mucin-secreting cells. It is suggested that baicalin and wogonin be further investigated for the possible use as mucoregulators during the treatment of chronic airway diseases(108).

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The Curable smoothie of Green tea, Blueberry and Apple for Reduced Risk and Treatment of Squamous cell skin cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for Squamous cell skin  cancer with little or no adverse effect.

Yield: 2 serving (about 8 ounce each)
1 cup blueberry
1/2 cup apple with peel on
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Squamous cell cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and often detected at an early stage. Squamous cell cancer arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.
Scientists working for some renowned institution may have found the ingredients from natural sources, including Green tea(1), blueberry(4) and apple(8) for reduced risk and treatment of Squamous cell cancer reported by most recent studies.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the Gifu University, Graduate School of Medicine, epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, suppressed the RECK gene in signalling cancer invasion in oral squamous cell carcinoma cell lines, through multiple mechanism(1).
Dr. Vyas S and colleagues at the Panjab University also suggested that in the study of the protective effect of tea consumption on risk of cutaneous squamous cell carcinoma (SCC), (-)-Epicatechin-3-gallate, of the principal catechins of green tea exhibits cancer-preventive activities in various animal models(2), including Squamous cell cancer. In a topical experiment, use of green tea concentrate plus Capsicum (Capsol-T®) for approximately 14 days, exhibited the apoptotic of carcinoma responded(3).
Dr. Clifford JL and Dr. DiGiovanni J. said,"..., green tea polyphenols in mouse models of UV-induced and chemically induced skin carcinogenesis and results of perillyl alcohol in a phase IIa clinical trial-all pointing to the great promise of this exciting approach for better understanding of and preventing skin cancer"(4), in the study of the promise of natural products for blocking early events in skin carcinogenesis.

Blueberry is a flower plant, belong to the family Eriaceae and native to Northern America.
Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry has shown to exhibit anti human skin squamous cell carcinoma A431 xenograft effect through induced apoptosis of tumor cell(5).
Also in the human skin squamous cell carcinoma A431 xenografts, the phytochemical induced death of cancer cell line through upregulated the protein and mRNA expression of anti tumor expression proteins, p53 and to downregulated the protein and mRNA expression of the inhibitor of survivin gene(6).
Furthermore, resveratrol (RES), induced the processes critical for the growth inhibition of keratinocytes in vitro and in vivo of that showed a promising potential for reduced risk and progression of squamous cell skin cancer(7). 

Ursolic acid is a phytochemincal in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc. The antioxidant exhibited strong and effective antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor, according to Ichimaru Pharcos Company Ltd.(8).
Dr. Kowalczyk MC and the colleagues at the University of Texas Health Science Center at San Antonio in the study of skin cancer prevention suggested that the antioxidant protects the alternation of keratinocytes causes of tumor growth progression by acting as tumor inhibition in protected cells from hydrogen peroxide-induced DNA damage(9).

Taking altogether people who are at increased of squamous cell skin cancer  due to family history or gene mutation, occupation .....should drink at least one serving daily and people with squamous cell skin cancer should drink the smoothie as much as they can, depending to digestive toleration.
Change life style and diet pattern are also recommended.

References
(1) Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells by Kato K1, Long NK, Makita H, Toida M, Yamashita T, Hatakeyama D, Hara A, Mori H, Shibata T.(PubMed)
(2) Potential O-acyl-substituted (-)-Epicatechin gallate prodrugs as inhibitors of DMBA/TPA-induced squamous cell carcinoma of skin in Swiss albino mice by Vyas S1, Manon B, Vir Singh T, Dev Sharma P, Sharma M.(PubMed)
(3) Response of carcinoma in situ (actinic keratosis) to green tea concentrate plus capsicum by Morré DJ1, Geilen CC, Welch AM, Morré DM.(PubMed)
(4) The promise of natural products for blocking early events in skin carcinogenesis by Clifford JL1, DiGiovanni J.(PubMed)
(5) [Study of apoptosis related factors regulatory mechanism of resveratrol to human skin squamous cell carcinomaA431 xenograft in nude mice].[Article in Chinese] by Hao YQ1, Huang WX, Feng HX, Zhang GH, Ning XH, Li HG, Hao CG, Li ZH.(PubMed)
(6) The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice by Hao Y1, Huang W, Liao M, Zhu Y, Liu H, Hao C, Liu G, Zhang G, Feng H, Ning X, Li H, Li Z.(PubMed)
(7) Differential effects of several phytochemicals and their derivatives on murine keratinocytes in vitro and in vivo: implications for skin cancer prevention by Kowalczyk MC1, Walaszek Z, Kowalczyk P, Kinjo T, Hanausek M, Slaga TJ.(PubMed)
(8) Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects by Banno N1, Akihisa T, Tokuda H, Yasukawa K, Higashihara H, Ukiya M, Watanabe K, Kimura Y, Hasegawa J, Nishino H.(PubMed)
(9) Differential effects of several phytochemicals and their derivatives on murine keratinocytes in vitro and in vivo: implications for skin cancer prevention by Kowalczyk MC1, Walaszek Z, Kowalczyk P, Kinjo T, Hanausek M, Slaga TJ.(PubMed)
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Most Common Diseases of elder: Respiratory Pleural disease: Pleural effusion Treatment Caused by Lupus

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                   Pleural disease: Pleural effusion

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural effusion is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.

                     The Treatment

 Treatments in conventional medicine perspective
Pleural effusion Treatments Caused by Lupus
Management of central nervous system (CNS) involvement still remains one of the most challenging problems in systemic lupus erythematosus (SLE). In the assessment of the diseases, some researchers suggested that the choice of treatment depends on the most probable underlying pathogenic mechanism and the severity of the presenting neuropsychiatric symptoms. Patients with mild manifestations may need symptomatic treatment only, whereas more severe acute nonthrombotic CNS manifestations may require pulse intravenous cyclophosphamide. Plasmapheresis may also be added in patients with more severe illness refractory to conventional treatment. Recently, the use of intrathecal methotrexate and dexamethasone has been reported in a small series of patients, with a good outcome in patients with severe CNS manifestations. Anticoagulation is warranted in patients with thrombotic disease, particularly in those with the antiphospholipid syndrome (APS). This article reviews the clinical approach to therapy in patients with CNS lupus(102)
Other suggested that the therapeutic choice depends on accurate diagnosis, identification of underlying pathogenic mechanism, severity of the presenting neuropsychiatric symptoms, and on prompt identification and management of contributing causes of CNS disease. Mild neuropsychiatric manifestations may need symptomatic treatment only. In more severe CNS disease it is important to distinguish between thrombotic and non-thrombotic mechanisms. Focal CNS manifestations, particularly TIA and stroke, are associated with the presence of antiphospholipid antibodies (aPL). Anticoagulation is warranted in patients with thrombotic disease, particularly in those with the antiphospholipid (Hughes) syndrome (APS). Other CNS manifestations, such as demyelinating syndrome, transverse myelitis, chorea, seizures, migraine and/or cognitive dysfunction, when associated with persistent positivity for aPL, may also benefit from anticoagulation in selected patients. Severe diffuse CNS manifestations, such as acute confusional state, generalised seizures, mood disorders and psychosis, generally require corticosteroids in the first instance. Pulse intravenous cyclophosphamide therapy may help when more severe manifestations are refractory to corticosteroids and other immunosuppressive agents, generally when response is not seen in 3-5 days. Plasmapheresis may also be added in severe cases of symptoms refractory to conventional treatment. Intravenous immunoglobulins, mycophenolate mofetil, rituximab, intratecal methotrexate and dexametasone deserve further studies to confirm their usefulness in the treatment of neuropsychiatric SLE(103)
1. Symptomatic therapy
1.1. Symptomatic therapy is defined as a medical therapy used to treat the symptoms of the disease but not its causes, such as Anti-inflammatory, Analgesic, Antitussives agents, etc.
b. Side effects are not limit to
b.1. Anti-Inflammatory agent (hypertension, skin rash and itching, gastrointestinal discomforts, ulcers and bleeding, kidney damage, etc.
b.2. Analgesics (long-term use of pain relievers can be addictive, stomach irritation, Over doses (2000 mg/day or more) can cause liver damage, etc.
b.3. Antitussives agents (Nausea, vomitin, skin rash and itching, welling, dizziness, etc.
2. Intravenous cyclophosphamide, methotrexate or dexamethasone or immunoglobulin
a. Depending to the severity of the diseases, medical condition, weight, response to therapy cyclophosphamide or methotrexate or dexamethasone or immunoglobulin is injection into a vein by your doctor or a healthcare professional.
b. Side effects sre not limit to
b.1. Cyclophosphamide (Nausea, vomiting, loss of appetite, stomach ache, diarrhea, s, temporary hair loss, unusual tiredness or weakness, joint pain, easy bruising/bleeding, etc.)
b.2. Methotrexate (Dizziness, general body discomfort, headache, loss of appetite, mild sore throat, mild stomach pain, nausea, vomiting, tiredness, etc.)
b.3. Dexamethasone (Difficulty sleeping, feeling of a whirling motion, increased appetite and sweating, indigestion; mood swing, nervousness, etc.)
b.4. Immunoglobulin(headache, dermatitis, chills, migraine, dizziness, fever, nausea, vomiting, fatigue , itching, increased Blood Pressure etc.)
3. Immunosuppressive Therapy
a. Immunosuppressive Therapy is defined as the treatment to suppress the immune response to antigen(s), on most cases it is used in conditions such as organ transplantation, autoimmune disease, allergy, etc.
b. Side effects are not limit to
b.1. Fever
b.2. High blood pressure
b.3. Kidney function.
b.4. Researchers found that Remissions were cyclosporine dependent in 26% of the patients responding to a regimen that included cyclosporine. Clonal or malignant diseases developed in 25% of the patients.
b.5. Etc.
4. Anticoagulant therapy
a. Anticoagulants is also well as blood thinners, used to slow the rate of blood clots of diseases such as thrombosis to atrial fibrillation.
b. Side effects are not limit to
b.1. Itching,
b.2. Rashes
b.3. Easy bruising,
b.4. Increased the risk of bleeding from injuries
b.5. Purplish spots on the skin
b.6. Etc.

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Friday, March 25, 2016

The Smoothie of Olive, Sweet Potato and Grape Juice for prevention and treatment of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndrome

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Cardiorenal syndrome is a term of interrelated of kidney and cardiovascular. As one disease of 
one organ can induce dysfunction of the other. The coexisting CVD and kidney disease or 'cardiorenal syndrome (CRS)' have a synergistic adverse clinical outcomes.

The smoothie for prevention and treatment of  Kidney disease induced by Cardiovascular disease in Cardiorenal syndrome
Yield: 2 servings (about 8 ounces each)

1/2 cup olive
1 cup cooked sweet potato
1 cup organic grape juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The finding of a natural source for treatment of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndrome

Chronic Kidney Diseases(CKD) in in Autosomal recessive polycystic kidney disease is a progressive loss of kidney function over period longer than 3 months through different stages, deepening to the GFR (Glomerular Filtration Rate). According to the Tri-Service General Hospital, Excessive oxidative stress increased oxidative nucleicacid damage and exagerated the development of complication of Chronic Kidney Diseases(1).

The Anti-Odxidant Therapy in Chronic Renal Insufficiency (ATIC) study suggested, combination of pravastatin, vitamin E, and homocysteine treatment in 18 months together with hypertension controlled  effectively attenuated expression of Chronic Kidney Diseases(CKD) through reduced oxidative stress against renal function(2).Vitamin E-coated membranes (VECMs) consist of a multilayer membrane with liposoluble vitamin E, used in dialysis significantly improved Hb levels and lower rHuEpo requirements in chronic HD patients(3).Dr. Rashid Khan M and colleagues insisted, vitamin E significantly reduced dyslipidemia and inhibited the development of CRD caused by atherogenic factors after six weeks. particular in hypolipidemic and nephroprotective activity against free radical-related diseases(4).

N-3 fatty acids found abundantly in olive may also contribute to the potential benefits of dietary fat
modification in CKD patients, according to the Karolinska Institutet(5).
Dr. Lee SM and Dr. An WS., professors at the Seoul National University Hospital, insisted, intake of Omega 3 fatty acid exhibited cardioprotective effects in chronic kidney disease, the main cause of death, through attenuated inflammation, dyslipidemia, malnutrition, atherosclerosis, and vascular calcification(6).
Dr. Friedman AN said, " Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA), which are obtained primarily from dietary sources such as coldwater fish, have diverse and potent mediating effects on the immune, inflammatory, and metabolic pathways, signal transduction, and cell membrane physiology" and "In the meantime, the current American Heart Association n-3 PUFA intake guidelines can be applied to CKD patients"(7).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry, may also benefit in attenuated complications and treatment of Chronic Kidney Diseases(CKD), through its inflammation and oxidative stress modulation (8).
According to the joint study led by the The Catholic University of Korea, Bucheon, resveratrol expressed renoprotective effects by activating NRF2 signaling against against oxidative or electrophilic stress(9).Furthermore by suppressing the pro inflammatory cytokines, consumption of white wine and olive oil, significantly reduced plasma markers of chronic inflammation in CKD patients(10).

The effectiveness of Cooked Sweet Potato, Olive and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndromewith little or no adverse effects.

People who are at high risk of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndrome should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.



References
(1) Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease by Sung CC1, Hsu YC, Chen CC, Lin YF, Wu CC.(PubMed)
(2) Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study by Nanayakkara PW1, van Guldener C, ter Wee PM, Scheffer PG, van Ittersum FJ, Twisk JW, Teerlink T, van Dorp W, Stehouwer CD.(PubMed)
(3) Effect of vitamin E-coated dialysis membranes on anemia in patients with chronic kidney disease: an Italian multicenter study by Cruz DN1, De Cal M, Garzotto F, Brendolan A, Nalesso D, Corradi V, Ronco C.(PubMed)
(4) Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats by Rashid Khan M1, Ahsan H, Siddiqui S, Siddiqui WA.(PubMed)
(5) Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond by Huang X1, Lindholm B, Stenvinkel P, Carrero JJ.(PubMed)
(6) Cardioprotective effects of ω -3 PUFAs in chronic kidney disease. by Lee SM1, An WS.(PubMed)
(7) Omega-3 fatty acid supplementation in advanced kidney disease by Friedman AN1.(PubMed)
(8) Resveratrol: why is it a promising therapy for chronic kidney disease patients?by Saldanha JF1, Leal Vde O2, Stenvinkel P3, Carraro-Eduardo JC4, Mafra D1.(PubMed)
(9) Effect of redox modulating NRF2 activators on chronic kidney disease.by Choi BH1, Kang KS2, Kwak MK3.(PubMed)

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The Smoothie of Cooked Tomato, Peanut and Olive for Prevention and Treatment in Autosomal dominant polycystic kidney disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

 The smoothie for prevention and treatment of  polycystic kidney disease (Renal cystic disease) 
Yield: 2 servings (about 8 ounces each)
3/4 cup cooked tomato
1/2 cup peanut
1/4 cup olive
1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
Autosomal dominant polycystic kidney disease, one of the most common forms of polycystic kidney disease is inherited diseases effecting approximately 400,000 people in the United States.

The finding of a natural source for treatment of Polycystic kidney disease (Renal cystic disease) in autosomal dominant polycystic kidney disease, has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Polycystic Kidney Disease in a utosomal dominant polycystic kidney disease,is an inherited diseases with fluid-filled cysts developed on the kidney. According to the University of Kansas Medical Center, the disease is associated to risk factors of aging, in older persons with multiple cysts probably induced by potassium deficiency, congenital disorders, metabolic diseases, and toxic renal injury(1).

Recent studies back by well known institutions proposed, Cooked Tomato, Peanut and Olive may be the next generation of natural ingredients for reduced complications and treatment of Polycystic kidney disease.

Vitamin B3 , also known as niacin, is a water-soluble vitamin.Vitamin B3 found abundantly in peanut may benefit patient with polycystic kidney disease(2). According to C.J. Janovy, administration of Vitamin B3 to a neonate, toddler or adolescent will effectively prevent or delay cyst formation and can be used for a lifetime(2).
Dr. Al Adlouni A and Dr. Hertig A. Said, "Vitamin B3 exhibited anti  autosomal dominant effect  involed the develop of polycystic kidney disease"(3).

Omaga 3 fatty acids found abundantly in flax seed also attenuated the progression of polycystic kidney disease, through alternation of multiple steps in PKD pathogenesis(4). According to the University of Guelph, mice fed with an n-3 fatty acid-enriched diet (MaxEPA) for 60 days, showed a marked decrease in the proportion of kidney area occupied by cysts in male but not in female rat(5).
Dr. Yamaguchi T and colleagues in the study led by the University of Manitoba, said,"Dietary flax oil may therefore reduce disease progression via mitigation of oxylipin abnormalities"(6) in patients with renal diseases.

Retinoic acids all-trans retinoic acid (AT-RA) and 9-cis retinoic acid (9C-RA) with function as of vitamin A suppressed the activation of the poly cystic kidney disease-1 (PKD1) promoter in's attenuated the diseases' progression(7). 
 Dr.Yamane A and professors at the Gunma University Graduate School of Medicine, said," A 63-year-old APL patient, complicated by Child-Pugh class A liver cirrhosis and polycystic kidney (creatinine 3.2 mg/dL), was successfully treated with 45 mg/m(2)/day of all-trans retinoic acid (ATRA)"(8).

The effectiveness of  Cooked Tomato, Peanut and Olive may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of polycystic kidney disease (Renal cystic disease) with little or no adverse effects.

People who are at high risk of polycystic kidney disease (Renal cystic disease) due to aging, weaken reno function... should drink at least one serving daily and women with polycystic kidney disease (Renal cystic disease) should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.



Refeneces
(1) Polycystic kidney disease: etiology, pathogenesis, and treatment by Martinez JR1, Grantham JJ.(PubMed)
(2) Vitamin B3 holds promise for treating polycystic kidney disease, research suggests, June 17, 2013
By C.J. Janovy
(3) [Vitamin B3 to prevent autosomal dominant polycystic kidney disease].[Article in French] by Al Adlouni A1, Hertig A2.(PubMed)
(4) Evidence for a role of proteins, lipids, and phytochemicals in the prevention of polycystic kidney disease progression and severity by Maditz KH1, Gigliotti JC, Tou JC.(PubMed)
(5) Effects of dietary supplementation with n-3 fatty acids on kidney morphology and the fatty acid composition of phospholipids and triglycerides from mice with polycystic kidney disease by Yamaguchi T1, Valli VE, Philbrick D, Holub B, Yoshida K, Takahashi H.(PubMed)
(6) Dietary flax oil rich in α-linolenic acid reduces renal disease and oxylipin abnormalities, including formation of docosahexaenoic acid derived oxylipins in the CD1-pcy/pcy mouse model of nephronophthisis by Yamaguchi T1, Devassy JG1, Gabbs M2, Ravandi A3, Nagao S4, Aukema HM5.(PubMed)
(7) Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter by Islam MR1, Puri S, Rodova M, Magenheimer BS, Maser RL, Calvet JP.(PubMed)
(8) Successful treatment by all-trans retinoic acid in a patient with acute promyelocytic leukemia complicated by liver cirrhosis and polycystic kidney by Yamane A1, Tsukamoto N, Saitoh T, Uchiumi H, Handa H, Karasawa M, Nojima Y, Murakami H.(PubMed)



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Most Common Diseases of elder: Respiratory Pleural disease: Pleural effusion Treatment caused by systemic diseases

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                   Pleural disease: Pleural effusion

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural effusion is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.

                     The Treatment

 Treatments in conventional medicine perspective
Pleural effusions caused by systemic diseases
Despite the low incidence (around 1%) of pleural effusions caused by systemic diseases, more often connective tissue diseases, such as rheumatoid arthritis or systemic lupus erythematosus.
Intra thoracic administration of cisplatin and sodium thiosulfate
In the study to to examine the pharmacokinetics and side effects of CDDP of Twenty-eight patients with malignant pleural effusion received instillation of cisplatin (CDDP) into the pleural cavity Thirteen patients received high-dose CDDP (120 mg/m2-160 mg/m2) in combination with sodium thiosulfate (STS), while 15 others received CDDP alone (80 mg/m2), found that malignant pleural effusion could be effectively treated by the instillation of CDDP 80 mg/m2 into the pleural cavity(104).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(104) http://www.ncbi.nlm.nih.gov/pubmed/3196043
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