Medical Advisor Journals

Wednesday, May 4, 2016

The Smoothie of Green tea, Tomato and Blueberry for Prevention an Treatment of CFHR5 nephropathy complication of Kidney Failure

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Complement factor H-related protein 5 (CFHR5) nephropathy

Yield: 2 servings (about 8 ounces each)

1/2 cup tomato

1 cup blueberry

1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Acute kidney failure in Complement factor H-related protein 5 (CFHR5) nephropathy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Complement factor H-related protein 5 (CFHR5) nephropathy (also known as Troodos nephropathy) is a form of inherited kidney disease in Cyprus caused by a mutation in the gene CFHR5, resulted in kidney failure in most cases.

Acute kidney failure is the rapid (less than 2 days) loss of your kidney function in removed waste and balanced fluids and electrolytes in your body. According to the Vrije Universiteit Brussel and Academic Hospital of the Vrije Universiteit Brussel, the progression of acute kidney failure also altered antioxidant defense in mouse adriamycin model(1), due to increased oxidative stress(2).

Recent studies back by well known institutions proposed, Green tea, Tomato and Blueberry may be the next generation of natural ingredients for prevention and treatment of Acute kidney failure in CFHR5 nephropathy.

In a small piglet model of extracorporeal circulation, the phytochemical also exhibited reno protective effects through its antioxidant, antiapoptotic and NO-scavenging properties(4).

Dr. Nasri H and professors led by the Isfahan University of Medical Sciences said," beneficial property of green tea, against renal toxicity of contrast media was observed. Green tea extract is an inexpensive, nontoxic, and effective treatment modality in individuals with a risk for acute kidney injury of contrast media"(5).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly grape and blueberry also
exhibited anti acute kidney diseases by prevented endotoxin-induced disruption of endothelial cell permeability and inhibited inflammation of kidney tissue(6).

According to the University of Arkansas for Medical Sciences, resveratrol reduced the mortality rate of patients who develop acute kidney injury during sepsis through improvement in capillary perfusion and increased renal blood flow and the glomerular filtration rate without raising systemic pressure(7).

Dr. Kim DH and colleagues at the Chonbuk National University said, " Resveratrol expressed modulation of p53 (antigen), by SIRT1 (in several separated cellular functions), could be a possible target to attenuate cisplatin-induced kidney injury"(8).

Lycopene found abundantly in tomato, a derivative of carotenoids also expressed nephroprotective effect against cisplatin-induced acute kidney injury in rats, according to the Firat University(9).

The Federal University of Santa Maria study, proposed " lycopene could plays a beneficial role in acute renal failure against HgCl(2) toxicity by preventing lipid peroxidation and changes in the activity of delta-aminolevulinate dehydratase and antioxidant enzymes"(10).

Dr. Ateşşahin A and colleagues in the investigation of the possible protective role of antioxidant treatment with lycopene on cyclosporine A-induced nephrotoxicity using biochemical and histopatological approaches found that natural antioxidant lycopene might have protective effect against cyclosporine-induced nephrotoxicity and oxidative stress in rat(11).

The effectiveness of Green tea, Tomato and Blueberry may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Acute kidney failure in CFHR5 nephropathy with little or no adverse effects.

People who are at high risk of Acute kidney failure in CFHR5 nephropathy due to mutation gene should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis

By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(1) Altered antioxidant defense in a mouse adriamycin model of glomerulosclerosis by Deman A1, Ceyssens B, Pauwels M, Zhang J, Houte KV, Verbeelen D, Van den Branden C.(PubMed)

(2) Increased oxidative stress in the mouse adriamycin model of glomerulosclerosis is accompanied by deposition of ferric iron and altered GGT activity in renal cortex by Ceyssens B1, Pauwels M, Meulemans B, Verbeelen D, Van den Branden C.(PubMed)

(3) Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass by Funamoto M1, Masumoto H1, Takaori K2, Taki T1, Setozaki S1, Yamazaki K1, Minakata K1, Ikeda T3, Hyon SH4, Sakata R1.(PubMed)

(4) Reno-protective effects of epigallocatechingallate in a small piglet model of extracorporeal circulation by Twal M1, Kiefer P, Salameh A, Schnabel J, Ossmann S, von Salisch S, Krämer K, Sobiraj A, Kostelka M, Mohr FW, Dhein S.(PubMed)

(5) A biochemical study on ameliorative effect of green tea (Camellia sinensis) extract against contrast media induced acute kidney injury by Nasri H1, Ahmadi A2, Baradaran A3, Nasri P4, Hajian S4, Pour-Arian A4, Kohi G5, Rafieian-Kopaei M5.(PubMed)

(6) Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages by Chen L1, Yang S, Zumbrun EE, Guan H, Nagarkatti PS, Nagarkatti M.(PubMed)

(7) Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury by Holthoff JH1, Wang Z, Seely KA, Gokden N, Mayeux PR.(PubMed)

(8) SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53 by Kim DH1, Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Han MK, Lee SY, Ramkumar KM, Sung MJ, Kim W.(PubMed)

(9) Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation by Erman F1, Tuzcu M, Orhan C, Sahin N, Sahin K.(PubMed)

(10) Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats by Augusti PR1, Conterato GM, Somacal S, Einsfeld L, Ramos AT, Hosomi FY, Graça DL, Emanuelli T.(PubMed)

(11) Lycopene, a carotenoid, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rats by Ateşşahin A1, Ceribaşi AO, Yilmaz S.(PubMed)

Most Common Diseases of 50plus: Restrictive lung diseases(Respiratory disease): The Risk factors and Diseases associated with

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

Restrictive lung diseases or restrictive ventilatory defects

Restrictive lung disease is a condition marked most obviously by a reduction in total lung capacity. A restrictive ventilatory defect may be caused by a pulmonary deficit, such as pulmonary fibrosis (abnormally stiff, non-compliant lungs), or by non-pulmonary deficits, including respiratory muscle weakness, paralysis, and deformity or rigidity of the chest wall(1).

The Risk factors and Diseases associated with

Risk Factors
1. Second hand smoke and genetic influence
Cigarette smoke not only causes Respiratory Disease, including Restrictive lung disease but also can influence early immune function as a potential to interact with other genetic factors and environmental risk factors to influence disease propensity(10).
2. Obesity
Obesity, particularly severe central obesity, affects respiratory physiology both at rest and during exercise as a result of ventilatory defect due to reductions in expiratory reserve volume, functional residual capacity, respiratory system compliance and impaired respiratory system. In the study by National Taiwan University Hospital, showed that obesity may also impair upper airway mechanical function and neuromuscular strength, and increase oxygen consumption, which in turn, increase the work of breathing and impair ventilatory drive. The combination of ventilatory impairment, excess CO(2) production and reduced ventilatory drive predisposes obese individuals to obesity hypoventilation syndrome(11).
3. Race
African Americans are at higher risk than white race in development of Restrictive lung disease.
4. Age
As the disease is a result of progression over prolonged period of time, most patients with restrictive lung disease are older than 50 years.
5. Etc.

Diseases associated with restrictive lung diseases
1. Heart diseases
In the study to explore the association of COPD and restrictive lung function impairment, respectively, with heart diseases in the general population in a cross-sectional study of 642 randomly selected 22- to 72-year-old subjects in northern Swede, found that there is a strong association between COPD and cardiovascular diseases and indicates a strong association between restrictive lung function and heart diseases. Both obstructive and restrictive lung function impairments were common among subjects with heart diseases and vice versa(12).
2. Ulcerative colitis
There is an association between ulcerative colitis and lung disease in which patients have chronic cough and show hyperplastic and inflammatory changes in their bronchial mucosa, according to the study by
Guy’s Hospital and Brook General Hospital(13).
3. Syringomyelia and syringobulbia
There is a report of three patients with syringomyelia and syringobulbia who developed severe respiratory complications. In neurological examination showed evidence of IXth and Xth cranial nerve involvement with dysphagia and dysphonia, but there were no complaints of serious sleep difficulties. Two patients died during sleep and the other was resuscitated during a nap. All patients showed moderate restrictive ventilatory defects with reduced maximal buccal pressures and one also showed a low ventilatory response to CO2 rebreathing(14).
4. Sarcoidosis
In the study to assess various lung function indices, including C(L,s) and D(L,CO), as markers of functional abnormality in sarcoidosis patients from 830 consecutive patients referred for lung function tests with a diagnosis of sarcoidosis (223 in stage I, 486 in stage II and 121 in stage III), found that
Normal total lung capacity was found in 772 (93%) patients. Of these cases, 24.5% had a low C(L,s) and 21.5% had a low D(L,CO). At least one abnormality was observed in 39.3% of these patients, whereas, in restrictive patients, this figure was 88%. Airway obstruction was present in 11.7% of cases(15).
5. Neuromuscular disease
The earliest sign of respiratory compromise in the patient with neuromuscular disease is nocturnal hypoventilation, which progresses over time to include daytime hypoventilation and eventually the need for full-time mechanical ventilation(16).
6. Other diseases
According to the study by Department of Public Health and Clinical Medicine, Umeå University, in restrictive lung function the prevalence of chronic rhinitis, cardiovascular disease, hyperlipemia and diabetes was higher compared to in Nlf (41.0% vs 32.3%, p = 0.017, 59.0% vs 41.0%, p<0.001, 29.2% vs.12.9%, p = 0.033, 20.9% vs 8.6%, p <0.001). In COPD and heart disease, 62.5% had chronic rhinitis and/or GERD, while in Nlf the corresponding proportion was 42.5%(17).
7. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1)http://oac.med.jhmi.edu/res_phys/Encyclopedia/RestrictVentDefect/RestrictVentDefect.HTML
(11) http://www.ncbi.nlm.nih.gov/pubmed/22212441
(12) http://www.ncbi.nlm.nih.gov/pubmed/23127573
(13) http://thorax.bmj.com/content/35/8/581.full.pdf
(14) http://www.ncbi.nlm.nih.gov/pubmed/1640236
(15) http://www.ncbi.nlm.nih.gov/pubmed/20378598
(16) http://www.ncbi.nlm.nih.gov/pubmed/23137740
(17) http://www.ncbi.nlm.nih.gov/pubmed/22149402

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The alternative Electrostimulation

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).

The Treatment

B. Treatment in herbal and traditional Chinese medicine
B.6. The alternative Electrostimulation
Electrostimulation has been applied to acupuncture to treat pain associate to the clips from the therapeutic device, are attached to the needles. This type of alternative application also was found in Ancient Egyptians and later the Greeks and Romans, dates back to thousands of years BC for treatment of pain, muscle dysfunction and sarcopenia(303).
Dr. Men'shikova IV. in the comment of combination of modern physiotherapeutic methods in rehabilitation said,"(Use of electrostimulation of smooth muscle) All patients(with RA) reported alleviation of pain and oedema in the affected joint. The rehabilitation period was 2-5 days shorter than after the traditional treatment(304).In support to the above study, the School of Rehabilitation Sciences, University of Ottawa, in the review of randomized controlled trials (RCTs) and controlled clinical trials (CCTs), case-control and cohort studies comparing ES against placebo or another active intervention in patients with RA showed that electrostimulation (ES) was shown to have a clinically beneficial effect on grip strength and fatigue resistance for RA patients with muscle atrophy of the hand but the evidences were limited due to low methodological quality of the trial included(305).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(303) Neuromuscular electrostimulation techniques: historical aspects and current possibilities in treatment of pain and muscle waisting by Heidland A1, Fazeli G, Klassen A, Sebekova K, Hennemann H, Bahner U, Di Iorio B.(PubMed)
(304) [Combination of modern physiotherapeutic methods in rehabilitation of patients with osteoarthrosis andrheumatoid arthritis after arthroscopic surgery on the knee joint].[Article in Russian] by Men'shikova IV.(PubMed)
(305) Electrical stimulation for the treatment of rheumatoid arthritis by Brosseau LU1, Pelland LU, Casimiro LY, Robinson VI, Tugwell PE, Wells GE.(PubMed)

The #Curablesmoothie of Green tea, Tomato and Brazil Nut for Prevention and treatment of Nonpuerperal mastitis

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The finding of a natural source for treatment of Nonpuerperal mastitis has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not
produced same potentials in large sample size and mutli centers human trials.

Non-puerperal mastitis, also known as non-lactating mastitis, includes(encompasses) all the causes of inflammatory changes in the female breast and mammilla(breast nipple) not related to lactation(pregnancy and breasting feeding). According to the guideline led by the Service de chirurgie gynécologique, hôpital Tenon, Non-puerperal mastitis depending to the underlying of the types and size of the infectious and inflammatory mastitis(8). Non-puerperal mastitis may be a masking pre-existing breast malignancy, resulted from chemical inflammation in the breast tissue, superimposed by a secondary bacterial infectionor or caused by sports activities or a seat belt injury(9).

The Incredible and Effective smoothie for Prevention and treatment of Nonpuerperal mastitis
Yield: 2 servings (about 8 ounces each)
1 cup tomato
1/2 cup Brazil nut
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Recent studies from well known institutions suggested that Green tea, Tomato and Brazil Nut

may process naturally potential ingredients, for reduced risk and treatment for mastitis.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its phytochemical EGCG normalized LPS-induced low activities of antioxidant enzymes as well as decreased the high levels of inflammatory cytokine into the duct of mammary gland(8).

According to the Agriculture and Agri-Food Canada, EGCG also expressed anti microbial effect against antibiotics-resistant strains of S. aureus in control of bovine mastitis and food poisoning caused by S. aureus12).

Vitamin A(Tomato or carrot), is a fat soluble vitamin was found to associate with low concentrations in cow with severity of mastitis(3). According to the University of Guelph, a 100 ng/mL increase in serum retinol was associated with a 60% decrease in the risk of early lactation clinical mastitis(4).
Dr. Erskine RJ said, " vitamins A (or beta-carotene) and E status should be monitored in herds" to prevent risk for mastitis and reproductive disorders(5).

Selenium one of most powerful antioxidant mineral found abundantly in Brazil nut may be used for prevention and treatment of mastitis and improved milk quality in dairy herds, according to the Ohio State University(6).

Dr. Hogan JS and colleagues at the Ohio State University suggested the important role of selenium in exhibition of immune modulated effect against mastitis, in animal model(7).

The effectiveness of Green Tea, Tomato and Brazil Nut may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Mastitis with little or no adverse effects.

Women who are at increased risk of Mastitis may drink at least one serving daily and women with Mastitis may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) Bioassay-guided purification and identification of antimicrobial components in Chinese green tea extract by Si W1, Gong J, Tsao R, Kalab M, Yang R, Yin Y.(PubMed)
(3) Relationship between vitamin A and beta-carotene in blood plasma and milk and mastitis in Holsteins by Chew BP, Hollen LL, Hillers JK, Herlugson ML.(PubMed)
(4) Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease by LeBlanc SJ1, Herdt TH, Seymour WM, Duffield TF, Leslie KE.(PubMed)
(5) Nutrition and mastitis by Erskine RJ1.(PubMed)
(6) Dietary vitamin E and selenium affect mastitis and milk quality by Smith KL1, Hogan JS, Weiss WP.(PubMed)
(7) Role of vitamin E and selenium in host defense against mastitis by Hogan JS1, Weiss WP, Smith KL.(PubMed)
(8) [Inflammatory and infectious breast mastitis outside of pregnancy and lactation: Guidelines].[Article in French]by Laas E1, Touboul C2, Kerdraon O3, Catteau-Jonard S4.(PubMed)
(9) Non-puerperal mastitis masking pre-existing breast malignancy: importance of follow-up imaging by Jin Kyung An1 , Jeong Joo Woo1 , Seung A Lee2(CrossMark)

Most Common Diseases of 50plus: Restrictive lung diseases(Respiratory disease): The Causes

The causes of restrictive lung disease are unknown but some researchers suggested the below
1. Cystic fibrosis
Recurrence is almost certainly more frequent in cystic fibrosis, and in view of the hazards of complication and the danger of bilateral pneumothoraces pleurodesis has to be considered. Of the various methods available, parietal pleurectomy is undoubtedly associated with the lowest incidence of
recurrence (Bromley, 1967; Heckscher, Larsen, and Lassen, 1966) and does not usually cause a restrictive ventilatory defect (Gobbel et al., 1963), so that provided the procedure is without undue risk it is the method of choice in this disease. In all three cases reported here there were severe obstructive
and restrictive defects of ventilatory capacity, but there were no immediate and serious post-operative complications, probably because of energetic physiotherapy and chemotherapy, according to the study by Brompton Hospital(5).
2. Cigarette smoke and air pollution
Welders exposed for over 10 years showed a prevalence of respiratory abnormalities significantly higher than those exposed for less than 10 years (44.4 vs 13.3%) (P less than 0.01) thereby showing that occupational exposure to welding fumes resulted in increased prevalence of pulmonary impairment in the welders. Smoking also had a contributory role thereby suggesting an interaction between smoking and welding exposure on the prevalence of pulmonary impairment in the welders engaged in brassware industries(6). Other suggested that in the study to investigate symptomatology, lung function, and radiographic change over an average period of 8 to 9 yr, of Sixty-four subjects with asbestos-related diffuse pleural thickening attending the London Medical Boarding Centre for Respiratory Diseases, showed that Chest pain was a common symptom, occurring in over half of the subjects. Approximately one-third of the subjects had a history of pleurisy or pleural effusion. Full long function, available in all cases, showed a highly significant decrement (p < 0.001) compared with predicted values in all variables except gas transfer coefficient (Kco) at initial presentation, consistent with a restrictive ventilatory defect(7).
3. Osteogenesis imperfecta (OI)
Osteogenesis imperfecta (OI) is an inherited connective tissue disorder characterized by bone fragility, multiple fractures and significant chest wall deformities. In the study of seven patients with severe OI type III, 15 with moderate OI type IV and 26 healthy subjects, found that the restrictive respiratory pattern of Osteogenesis Imperfecta is closely related to the severity of the disease and to the sternal deformities. Pectus carinatum characterizes OI type III patients and alters respiratory muscles coordination, leading to chest wall and rib cage distortions and an inefficient ventilator pattern. OI type IV is characterized by lower alterations in the respiratory function(8).
4. Connective tissue diseases
In the study to perform PFT in rheumatoid arthritic patients without pulmonary involvement and to identify variables related to changes in PFT over 5 years of follow-up in 82 patients (21 men, 61 women), found that among the 67 surviving patients, 38 (56.7%) agreed to participate in a follow-up study. The initial PFT revealed normal PFT in only 30 patients (36.6%); an obstructive ventilatory defect in 2 (2.4%), a small airway defect in 12 (17%), a restrictive ventilatory defect in 21 (25.6%), and reduced DLco in 17 (20.7%). Among the 38 patients participating in the 5 year follow-up study, 8 developed respiratory symptoms, one patient had a new obstructive ventilatory defect, one patient developed a restrictive ventilatory defect, and 5 patients had a newly developed small airway defect(9).
5. Etc.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1)http://oac.med.jhmi.edu/res_phys/Encyclopedia/RestrictVentDefect/RestrictVentDefect.HTML
(4) http://www.ncbi.nlm.nih.gov/pubmed/8542134
(5) http://thorax.bmj.com/content/25/2/165.full.pdf
(6) http://www.ncbi.nlm.nih.gov/pubmed/1915188
(7) http://www.ncbi.nlm.nih.gov/pubmed/8542134
(8) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338769/
(9) http://www.ncbi.nlm.nih.gov/pubmed/19432035

Tuesday, May 3, 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The Miracle Topical Remedies

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).

The Treatment

B. Treatment in herbal and traditional Chinese medicine
B.5. The Miracle Topical Remedies
Certain topical remedies used in traditional or folk medicine have found effective on attenuate persistent symptoms of rheumatoid arthritis1. Capsaicin cream
Topical Capsaicin cream used for treatment of soft tissue with a pharmaceutical name of Finalgon®(420), has been shown effectively to reduced symptoms of pain of 80% of patient with rheumatoid arthritis in a double-blind randomized study, 70 patients with osteoarthritis (OA) and 31 with rheumatoid arthritis (RA)(301a). Dr. Rumsfield JA and Dr. West DP. Said," Although capsaicin is clinically used as an external analgesic for temporary relief of neuralgia, it has also been widely used as a research tool to study peripheral pain"(302). of that may be reason for the topical is recommended for treatment in patient with RA in modern herbal and TCM practitioners.

2. Avocado soybean unsaponifiables (ASU)
Avocado soybean unsaponifiables (ASU) is a natural vegetable extract composed of one-third avocado oil and two-thirds soybean oil, may be used effectively for treatment of knee osteoarthritis to replace the use of analgesics and nonsteroidal antiinflammatory drugs (NSAIDs), according to the a three-month, prospective, randomized, double-blind, placebo-controlled, parallel-group trial(372,294)).
In rat model, administration of avocado/soybean unsaponifiable (ASU), reduced bone resorption, expression of TRAP and RANKL through its positive effect on bone repair following ligature-induced periodontitis(295). Dr. Pirotta M said," Despite support for some of the most popular CAM therapies for pain from arthritis-related conditions, additional high quality research is needed for other therapies, especially for herbals and homeopathy"(296).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(294)
(295) Effect of avocado/soybean unsaponifiables on ligature-induced bone loss and bone repair after ligature removal in rats by Oliveira GJ1, Paula LG1, Souza JA1, Spin-Neto R2, Stavropoulos A3, Marcantonio RA1.(PubMed)
(296) Selected CAM therapies for arthritis-related pain: the evidence from systematic reviews by Soeken KL1.(PubMed)
(301a) Treatment of arthritis with topical capsaicin: a double-blind trial by Deal CL1, Schnitzer TJ, Lipstein E, Seibold JR, Stevens RM, Levy MD, Albert D, Renold F.(PubMed)
(302) Topical capsaicin in dermatologic and peripheral pain disorders by Rumsfield JA1, West DP.(PubMed)

The Smoothie of Avocado, Sweet Potato, Carrot and vitamin D fortified low fat milk for Reduced Risk and Treatment of Primary Sclerosing Cholangitis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced symptoms and treatment of Primary Sclerosing Cholangitis
Yield: 2 serving (about 8 ounce each)
1 cups avocado
1/4 cup sweet potato
1/4 cup carrot
1 cup vitamin D fortified low fat milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of Primary Sclerosing Cholangitis is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Primary Sclerosing Cholangitis is a condition of inflammation, causing scars within the bile ducts. According to the University of Birmingham, loss of regulation of CD28 T cells inflammatory expression may contributes to parthenogenesis of primary sclerosing cholangitis(1)(2)

Intake of vitamin D, a fat soluble vitamin found abundantly in fortified low fat milk may benefit patients with primary sclerosing cholangitis(1), probably through its immunomodulatory and modulate autoimmune liver-disease effect of primary sclerosing cholangitis(3)(4).

Intake of avocado containing high amount of Docosahexaenoic acid (DHA)(7), an omega-3 fatty acid may be associated to reduced risk of Primary Sclerosing Cholangitis(6).
The Beth Israel Deaconess Medical Center study siad, " Oral DHA supplementation is associated with an increase in serum DHA levels and a significant decline in alkaline phosphatase levels in patients with PSC"(5).

Furthermore, additional intake of vitamin A(carrot) and E(sweet potato) may also be helpful in attenuated the progression of Primary Sclerosing Cholangitis as patients with the disease are found to associate with 82% deficient in vitamin A and 43% deficient in vitamin E, the Mayo Clinic insisted(8).

The combination of Avocado, Sweet Potato, Carrot and vitamin D fortified low fat milk smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Primary Sclerosing Cholangitis without inducing adverse effects.

People who are at increased risk of Primary Sclerosing Cholangitis due to aging, family history .....should drink at least one cup daily and people with Primary Sclerosing Cholangitis should drink the juices at least 3 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis by Liaskou E1, Jeffery LE2, Trivedi PJ1, Reynolds GM1, Suresh S1, Bruns T3, Adams DH1, Sansom DM4, Hirschfield GM5.(PubMed)
(2) Tumour necrosis factor alpha impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis by Bo X1, Broome U, Remberger M, Sumitran-Holgersson S.(PubMed)
(3) 1,25-(OH)₂-vitamin D₃ prevents activation of hepatic stellate cells in vitro and ameliorates inflammatory liver damage but not fibrosis in the Abcb4(-/-) model by Reiter FP1, Hohenester S2, Nagel JM2, Wimmer R2, Artmann R2, Wottke L2, Makeschin MC3, Mayr D3, Rust C4, Trauner M5, Denk GU2.(PubMed)
(4) Vitamin D in autoimmune liver disease by Smyk DS1, Orfanidou T, Invernizzi P, Bogdanos DP, Lenzi M.(PubMed)
(5) The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study by Martin CR1, Blanco PG, Keach JC, Petz JL, Zaman MM, Bhaskar KR, Cluette-Brown JE, Gautam S, Sheth S, Afdhal NH, Lindor KD, Freedman SD.(PubMed)
(6) Decreased peroxisome proliferator activated receptor alpha is associated with bile duct injury in cystic fibrosis transmembrane conductance regulator-/- mice by Pall H1, Zaman MM, Andersson C, Freedman SD.(PubMed)
(7) Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit by Kim OK1, Murakami A, Nakamura Y, Takeda N, Yoshizumi H, Ohigashi H.(PubMed)
(8) Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis by Jorgensen RA1, Lindor KD, Sartin JS, LaRusso NF, Wiesner RH.(PubMed)