Thursday, May 5, 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: Acupuncture

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).



                            The Treatment


B. Treatment in herbal and traditional Chinese medicine
B.7. Other essential alternative medicine treatment
2. Acupuncture
The most oldest form of medical treatment in traditional Chinese medicine has been known for its function in relief pain(383,313) and functional limitation(384,314) for chronic patient, including patient with moderate or severe chronic pain(383,313).
The Cochrane Field of Rehabilitation and Related Therapies and the Cochrane Musculoskeletal Review suggests the effectiveness of acupuncture as a rehabilitation of an adjunct therapy for the symptomatic treatment of rheumatoid arthritis showed to reduce symptomatic knee pain in patients with RA 24 hours and 4 months post treatment(315). According to Dr. Wang C and the research team at the Tufts Medical Center and Tufts University School of Medicine, acupuncture showed to decrease pain, significant reduced morning stiffness and inflammatory markers in comparison to controls in patients with rheumatoid arthritis(316).In a total of 80 eligible patients, 36 patients with mean age of 58 study, electroacupuncture (EA) and traditional Chinese acupuncture (TCA) significantly reduced tender joints and improved physician's and patients global score but large scale trial are recommended in orderto clarify the existing evidence base on acupuncture for RA.(317).
In the discuss of the imbalance between T-helper 17 (Th17) cells and regulatory T (Treg) cells induced rheumatoid arthritis, use of electroacupuncture (EA) not only restores the balance of Th17/Treg cell but also expresses its anti-inflammatory effects through educed paw volumes, arthritis scores and inflammation scores(319) in collagen-induced arthritis (autoimmune disease ) rats(320).


In fact, poor quality of studies and conflicting evidence exists in placebo-controlled trials, in some cases are also found to accompany with certain inconsistency of its efficacy(318).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(313)
(314)
(315) Acupuncture and electroacupuncture for the treatment of rheumatoid arthritis by Casimiro L1, Barnsley L, Brosseau L, Milne S, Robinson VA, Tugwell P, Wells G.(PubMed)
(316) Acupuncture for pain relief in patients with rheumatoid arthritis: a systematic review by Wang C1, de Pablo P, Chen X, Schmid C, McAlindon T.(PubMed)
(317)Acupuncture in the treatment of rheumatoid arthritis: a double-blind controlled pilot study.
Tam LS1, Leung PC, Li TK, Zhang L, Li EK.(PubMed)
(318) A pilot study of acupuncture as adjunctive treatment of rheumatoid arthritis by Zanette Sde A1, Born IG, Brenol JC, Xavier RM.(PubMed)

The Smoothie of Sweet Potato, Peanut and Green Tea for Prevention and Treatment of Sexually Transmitted Diseases

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Sexually Transmitted Diseases
Yield: 2 servings (about 8 ounces each)
1 cup sweet potato
1/2  cup peanut
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Sexually Transmitted Diseases has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Sexually Transmitted Diseases is a condition of microbial infection spread by sex,particular vaginal intercourse, anal sex and oral sex.

Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Its phytochemicals EGCG, have been found to process anti semen-derived enhancer of viral infection(SEVI) and block the combination of HIV and SEVI or prevent the formation of amyloid fiber induced sexual transmission of HIV infection(1).

Sinecatechins, a green tea extract, inhibited human papillomavirus (HPV) in human disease including external genital and perianal warts (EGW), with some HPV genotypes having oncogenic potentialgenes by modulates and downregulates genes involved in the pro-inflammatory response to HPV infection(2)
Dr. Rosen T said, "... the clinical implications of catechins for the treatment of external genital and perianal warts (EGWs) and other conditions caused by human papillomavirus (HPV)" and "... in the treatment of EGWs and other HPV-related conditions may be related to or associated with postulated or proven antiviral and immunostimulatory activity,.."(3).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in  peanut may also display protective effect of microbial induced Sexually Transmitted Diseases. According to the joint study led by the University Hospital of North Norway, the phytochemical exhibited anti vaginal inflammation and infections effects through its antioxidant activities(4).
According to Dr. Singh G and Dr. Pai RS. said, " resveratrol a therapeutically potent drug. Providing a relatively pithy overview, this paper thus presents recent advances ofresveratrol for the treatment and prevention of HIV/AIDS"(5).
In herpes simplex virus vaginal infection, according to the Northeastern Ohio Universities College of Medicine, application of 19% resveratrol did significantly limit vaginal HSV-1 replication and reduced extravaginal lesion formation(6).

Vitamin E, found abundantly in sweet potato may also benefit for prevention and treatment of Sexually Transmitted Diseases inclluding HIV infection. Patients with HIV/AIDS are associated to predisposed to vitamin E deficiency , according to the joint study led by theUniversity of São Paulo(7). Dr. De Luca C and colleagues in the investigation of the effects of antioxidants on Sexually Transmitted Diseases, suggested. "positive clinical outcomes of the selected nutriceutical (Coenzyme Q(10), vitamin E, selenium, and methionine) associated with conventional protocols in the management of relapsing mucocutaneous human papillomavirus and herpes infections"(8).

The combination of Sweet Potato, Peanut and Green Tea may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Mouth (Oral) cancer without inducing adverse effects.

People who are at higher risk of  Sexually Transmitted Diseases due to sexual active, weaken immunity.......should take at least one serving daily. People with Sexually Transmitted Diseases should drink as much as they can depending to the digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) [Semen-derived enhancer of viral infection--a key factor in sexual transmission of HIV].[Article in Chinese]by Duan JM1, Qiu JY, Tan SY, Liu SW, Li L.(PubMed)
(2) Expression patterns of immune-associated genes in external genital and perianal warts treated with sinecatechins by Doan HQ1, Nguyen HP, Rady P, Tyring SK(PubMed)
(3) Green tea catechins: biologic properties, proposed mechanisms of action, and clinical implications by Rosen T1.(PubMed)
(4) Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections by Jøraholmen MW1, Škalko-Basnet N2, Acharya G3, Basnet P4.(PubMed)
(5) Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS. by Singh G1, Pai RS2.(PubMed)
(6) Effect of resveratrol on herpes simplex virus vaginal infection in the mouse by Docherty JJ1, Fu MM, Hah JM, Sweet TJ, Faith SA, Booth T.(PubMed)
(7) Vitamin E concentrations in adults with HIV/AIDS on highly active antiretroviral therapy by Itinoseki Kaio DJ1, Rondó PH2, Luzia LA3, Souza JM4, Firmino AV5, Santos SS6.(PubMed)
(8) Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections by De Luca C1, Kharaeva Z, Raskovic D, Pastore P, Luci A, Korkina L.(PubMed)

Most Common Diseases of 50plus: Restrictive lung diseases(Respiratory disease): The Diagnosis

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                           Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

   Restrictive lung diseases or restrictive ventilatory defects


Restrictive lung disease is a condition marked most obviously by a reduction in total lung capacity. A restrictive ventilatory defect may be caused by a pulmonary deficit, such as pulmonary fibrosis (abnormally stiff, non-compliant lungs), or by non-pulmonary deficits, including respiratory muscle weakness, paralysis, and deformity or rigidity of the chest wall(1).

                            The Diagnosis 

If you are experience some of the above symptoms and if your doctor suspects that you have restrictive lung function, after recording your family history and completing the physical exam, the test which your doctor orders include
1. Chest CT scan and echocardiography
In the study to examine the frequency and spectrum of diseases associated with isolated reduction in the diffusing capacity of lung for carbon monoxide (D(Lco)) of the 38,095 patients who underwent PFTs during the study period, 179 (0.47%; 95% confidence interval [CI], 0.40%-0.54%) had isolated D(Lco) abnormalities. The 27 patients (15.1%; 95% CI, 10.2%-21.2%) who had also undergone chest CT and echocardiography within 1 month of PFTs form the study cohort reported herein. Their mean D(Lco) was 50% +/- 15% (95% CI, 45%-56%) with average normal pulse oxygen saturation at rest and mild hypoxemia with activity. Thirteen of the 27 patients (48%; 95% CI, 28.7%-68.1%) had underlying emphysema evident on CT. Eleven of these 13 patients had emphysema associated with a restrictive lung process. The 14 patients without emphysema had interstitial lung disease, pulmonary vascular disease, and other isolated findings(18).
2. Utility of cardiopulmonary exercise testing
Restrictive lung disease occurs commonly in patients with neuromuscular disease.Exercise testing is mandatory because pulmonary function tests at rest are not reliable for the diagnostic evaluation and functional characterisation of these patients. Cardiopulmonary exercise testing (CPET) with measurement of gas exchange is the favoured tool. It is an excellent method to investigate exercise dyspnea, describe altered physiological response to exercise and characterise the involved organ systems heart, lung and muscle(19).
3. FEV1/FVC ratio test
The aim of the test is to analyze the forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). In patients with restrictive lung disease, ratio is higher than 80% as the decline in FVC is more than that of FEV1. In the study use of clinical and spirometry findings in order to distinguish between the restrictive and nonspecific patterns of pulmonary function test results in patients with low FVC and a normal or elevated FEV1/FVC ratio, showed that the most common causes of a nonspecific pattern were obstructive disorders, congestive heart failure, obesity, bronchiolitis, interstitial diseases, and neuromuscular disorders. In patients given a working diagnosis of pulmonary fibrosis, pleural disease, or chest wall disease, the positive predictive value (PPV) for restriction was >or= 90%. In males, an FVC <or= 60% of predicted had a PPV for restriction of 98.8%. In females, the restrictive pattern was found in 84.4% of those with an FVC <or= 50% of predicted. A difference of >or= 0% between the FEV1% and the FVC% had a PPV for restriction of 89.5%. After performing logistic regression, we developed a point scale for predicting the restrictive pattern(20).
4. Spirometry
Spirometry measures the flow and volume of air entering and leaving the lungs. It is used to assess ventilatory function and differentiates between normality and diseases causing obstructive and possibly restrictive defects(21).
4. Etc.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1)http://oac.med.jhmi.edu/res_phys/Encyclopedia/RestrictVentDefect/RestrictVentDefect.HTML
(18) http://www.ncbi.nlm.nih.gov/pubmed/17285785
(19) http://www.ncbi.nlm.nih.gov/pubmed/19924618
(20) http://www.ncbi.nlm.nih.gov/pubmed/20835593
(21) http://www.ncbi.nlm.nih.gov/pubmed/21597532

Wednesday, May 4, 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The Ice or Heat Therapies

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).



                            The Treatment



B. Treatment in herbal and traditional Chinese medicine

B.7. Other essential alternative medicine treatment
Beside suggesting certain herbal medicine for treatment of osteoarthritis, modern herbal and TCM medicine doctors may also combine other natural treatment for alleviating symptoms of the disease1. Ice or Heat Therapies
1.1. Ice therapy
Ice therapy, using the techniques of compression and elevation basic principles for treatment of acute soft tissue injury, if applied correctly with repeated application of 10 minutes for avoiding side effects, and preventing possible further injury(306). According to Dr. van den Bekerom MP and the research team at the Orthopaedic Research Center Amsterdam, treatment of pain, swelling, ankle mobility or range of motion, must be made on an individual basis, carefully weighing the relative benefits and risks of each option, and must be based on expert opinions and national guidelines(307).
Unfortunately, according to the study of University of Ottawa, thermotherapy, including hot and ice packs application is found a significant effects on arthritic hands of patient with rheumatoid arthritis and most studies(308).


1.2. Heat therapy
Heat therapy, is another form of thermotherapy with the use of heat in therapy for pain relief by alternative rehabilitation specialists. The review of studied that met the criteria of 328 subjects, by the University of Ottawa, superficial moist heat is found effective for relieved joint swelling, pain, reduced medication intake, improved range of motion (ROM), grip strength, hand function but limited by methodological considerations such as the poor quality of trials(309). In support of the above, the research team lead by Dr. found that in 17 with symmetrical rheumatoid arthritis (RA) applied heat to 1 hand twice daily for 2 years, heat therapy improve joint swelling, joint tenderness and grip strength with daily heat therapy did not accelerate the proliferative lesion in RA(310).

In regard of thermotherapy used of heat and cold treatment, Dr. Oosterveld FG and Dr. Rasker JJ said,s" In general, locally applied heat increases and locally applied cold decreases the temperature of the skin, superficial and deeper tissues, and joint cavity. Most studies dealing with the effects of heat and cold on pain, joint stiffness, grip strength, and joint function in inflamed joints report beneficial effects" and " In vitro studies show that higher temperatures increase the breakdown of articular cartilage and tissues that contain collagen".(311)


And according to the traditional Chinese medicine, correlation between cold and hot pattern are related to different pathways, and the network of that might be used for identifying the pattern and classification in other diseases including subsets of RA(312).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(306) Ice therapy: how good is the evidence? by Mac Auley DC1.(PubMed)
(307) What is the evidence for rest, ice, compression, and elevation therapy in the treatment of ankle sprains in adults? by van den Bekerom MP1, Struijs PA, Blankevoort L, Welling L, van Dijk CN, Kerkhoffs GM.(PubMed)
(308) Thermotherapy for treating rheumatoid arthritis by Robinson V1, Brosseau L, Casimiro L, Judd M, Shea B, Wells G, Tugwell P.(PubMed)(309) Thermotherapy for treating rheumatoid arthritis by Welch V1, Brosseau L, Shea B, McGowan J, Wells G, Tugwell P.(PubMed)
(310) Rheumatoid arthritis: failure of daily heat therapy to affect its progression by Mainardi CL, Walter JM, Spiegel PK, Goldkamp OG, Harris ED Jr.(PubMed)
(311) Treating arthritis with locally applied heat or cold by Oosterveld FG1, Rasker JJ.(PubMed)

(312) Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles inrheumatoid arthritis by Jiang M1, Xiao C, Chen G, Lu C, Zha Q, Yan X, Kong W, Xu S, Ju D, Xu P, Zou Y, Lu A.(PubMed)

The Smoothie of Green tea, Tomato and Blueberry for Prevention an Treatment of CFHR5 nephropathy complication of Kidney Failure

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Complement factor H-related protein 5 (CFHR5) nephropathy
Yield: 2 servings (about 8 ounces each)

1/2 cup tomato
1 cup blueberry
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Acute kidney failure in Complement factor H-related protein 5 (CFHR5) nephropathy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Complement factor H-related protein 5 (CFHR5) nephropathy (also known as Troodos nephropathy) is a form of inherited kidney disease in Cyprus caused by a mutation in the gene CFHR5, resulted in kidney failure in most cases.

Acute kidney failure is the rapid (less than 2 days) loss of your kidney function in removed waste and  balanced fluids and electrolytes in your body. According to the Vrije Universiteit Brussel and Academic Hospital of the Vrije Universiteit Brussel, the progression of acute kidney failure also altered antioxidant defense in mouse adriamycin model(1), due to increased oxidative stress(2).

Recent studies back by well known institutions proposed, Green tea, Tomato and Blueberry may be the next generation of natural ingredients for prevention and treatment of Acute kidney failure in CFHR5 nephropathy.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the study led by the Kyoto University Graduate School of Medicine, epigallocatechin-3-gallate (EGCG) is a major component of the polyphenolic fraction of green tea, ameliorated (Acute kidney failure) AKI in a cardiopulmonary bypass (CPB) model of diabetic rats through antioxidative properties(3).
In a small piglet model of extracorporeal circulation, the phytochemical also exhibited reno protective effects through its antioxidant, antiapoptotic and NO-scavenging properties(4).
Dr. Nasri H and professors led by the Isfahan University of Medical Sciences said," beneficial property of green tea, against renal toxicity of contrast media was observed. Green tea extract is an inexpensive, nontoxic, and effective treatment modality in individuals with a risk for acute kidney injury of contrast media"(5).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly grape and blueberry also
exhibited anti acute kidney diseases by prevented endotoxin-induced disruption of endothelial cell permeability and inhibited inflammation of kidney tissue(6).
According to the University of Arkansas for Medical Sciences, resveratrol reduced the mortality rate of patients who develop acute kidney injury during sepsis through improvement in capillary perfusion and increased renal blood flow and the glomerular filtration rate without raising systemic pressure(7).
Dr. Kim DH and colleagues at the Chonbuk National University said, " Resveratrol expressed modulation of p53 (antigen), by SIRT1 (in several separated cellular functions), could be a possible target to attenuate cisplatin-induced kidney injury"(8).

Lycopene found abundantly in tomato, a derivative of carotenoids also expressed nephroprotective effect against cisplatin-induced acute kidney injury in rats, according to the Firat University(9).
The Federal University of Santa Maria study, proposed " lycopene could plays a beneficial role in acute renal failure against HgCl(2) toxicity by preventing lipid peroxidation and changes in the activity of delta-aminolevulinate dehydratase and antioxidant enzymes"(10).
Dr. Ateşşahin A and colleagues in the investigation of the possible protective role of antioxidant treatment with lycopene on cyclosporine A-induced nephrotoxicity using biochemical and histopatological approaches found that natural antioxidant lycopene might have protective effect against cyclosporine-induced nephrotoxicity and oxidative stress in rat(11).

The effectiveness of  Green tea, Tomato and Blueberry may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Acute kidney failure in CFHR5 nephropathy with little or no adverse effects.

People who are at high risk of Acute kidney failure in CFHR5 nephropathy due to mutation gene should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.


References
(1) Altered antioxidant defense in a mouse adriamycin model of glomerulosclerosis by Deman A1, Ceyssens B, Pauwels M, Zhang J, Houte KV, Verbeelen D, Van den Branden C.(PubMed)
(2) Increased oxidative stress in the mouse adriamycin model of glomerulosclerosis is accompanied by deposition of ferric iron and altered GGT activity in renal cortex by Ceyssens B1, Pauwels M, Meulemans B, Verbeelen D, Van den Branden C.(PubMed)
(3) Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass by Funamoto M1, Masumoto H1, Takaori K2, Taki T1, Setozaki S1, Yamazaki K1, Minakata K1, Ikeda T3, Hyon SH4, Sakata R1.(PubMed)
(4) Reno-protective effects of epigallocatechingallate in a small piglet model of extracorporeal circulation by Twal M1, Kiefer P, Salameh A, Schnabel J, Ossmann S, von Salisch S, Krämer K, Sobiraj A, Kostelka M, Mohr FW, Dhein S.(PubMed)
(5) A biochemical study on ameliorative effect of green tea (Camellia sinensis) extract against contrast media induced acute kidney injury by Nasri H1, Ahmadi A2, Baradaran A3, Nasri P4, Hajian S4, Pour-Arian A4, Kohi G5, Rafieian-Kopaei M5.(PubMed)
(6) Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages by Chen L1, Yang S, Zumbrun EE, Guan H, Nagarkatti PS, Nagarkatti M.(PubMed)
(7) Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury by Holthoff JH1, Wang Z, Seely KA, Gokden N, Mayeux PR.(PubMed)
(8) SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53 by Kim DH1, Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Han MK, Lee SY, Ramkumar KM, Sung MJ, Kim W.(PubMed)
(9) Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation by Erman F1, Tuzcu M, Orhan C, Sahin N, Sahin K.(PubMed)
(10) Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats by Augusti PR1, Conterato GM, Somacal S, Einsfeld L, Ramos AT, Hosomi FY, Graça DL, Emanuelli T.(PubMed)
(11) Lycopene, a carotenoid, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rats by Ateşşahin A1, Ceribaşi AO, Yilmaz S.(PubMed)

Most Common Diseases of 50plus: Restrictive lung diseases(Respiratory disease): The Risk factors and Diseases associated with

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                           Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

   Restrictive lung diseases or restrictive ventilatory defects


Restrictive lung disease is a condition marked most obviously by a reduction in total lung capacity. A restrictive ventilatory defect may be caused by a pulmonary deficit, such as pulmonary fibrosis (abnormally stiff, non-compliant lungs), or by non-pulmonary deficits, including respiratory muscle weakness, paralysis, and deformity or rigidity of the chest wall(1).


            The Risk factors and Diseases associated with 

Risk Factors
1. Second hand smoke and genetic influence
Cigarette smoke not only causes Respiratory Disease, including Restrictive lung disease but also can influence early immune function as a potential to interact with other genetic factors and environmental risk factors to influence disease propensity(10).
2. Obesity
Obesity, particularly severe central obesity, affects respiratory physiology both at rest and during exercise as a result of ventilatory defect due to reductions in expiratory reserve volume, functional residual capacity, respiratory system compliance and impaired respiratory system. In the study by National Taiwan University Hospital, showed that obesity may also impair upper airway mechanical function and neuromuscular strength, and increase oxygen consumption, which in turn, increase the work of breathing and impair ventilatory drive. The combination of ventilatory impairment, excess CO(2) production and reduced ventilatory drive predisposes obese individuals to obesity hypoventilation syndrome(11).
3. Race
African Americans are at higher risk than white race in development of Restrictive lung disease.
4. Age
As the disease is a result of progression over prolonged period of time, most patients with restrictive lung disease are older than 50 years.
5. Etc.


 Diseases associated with restrictive lung diseases
1. Heart diseases
In the study to explore the association of COPD and restrictive lung function impairment, respectively, with heart diseases in the general population in a cross-sectional study of 642 randomly selected 22- to 72-year-old subjects in northern Swede, found that there is a strong association between COPD and cardiovascular diseases and indicates a strong association between restrictive lung function and heart diseases. Both obstructive and restrictive lung function impairments were common among subjects with heart diseases and vice versa(12).
2. Ulcerative colitis
There is an association between ulcerative colitis and lung disease in which patients have chronic cough and show hyperplastic and inflammatory changes in their bronchial mucosa, according to the study by
Guy’s Hospital and Brook General Hospital(13).
3. Syringomyelia and syringobulbia
There is a report of three patients with syringomyelia and syringobulbia who developed severe respiratory complications. In neurological examination showed evidence of IXth and Xth cranial nerve involvement with dysphagia and dysphonia, but there were no complaints of serious sleep difficulties. Two patients died during sleep and the other was resuscitated during a nap. All patients showed moderate restrictive ventilatory defects with reduced maximal buccal pressures and one also showed a low ventilatory response to CO2 rebreathing(14).
4. Sarcoidosis
In the study to assess various lung function indices, including C(L,s) and D(L,CO), as markers of functional abnormality in sarcoidosis patients from 830 consecutive patients referred for lung function tests with a diagnosis of sarcoidosis (223 in stage I, 486 in stage II and 121 in stage III), found that
Normal total lung capacity was found in 772 (93%) patients. Of these cases, 24.5% had a low C(L,s) and 21.5% had a low D(L,CO). At least one abnormality was observed in 39.3% of these patients, whereas, in restrictive patients, this figure was 88%. Airway obstruction was present in 11.7% of cases(15).
5. Neuromuscular disease
The earliest sign of respiratory compromise in the patient with neuromuscular disease is nocturnal hypoventilation, which progresses over time to include daytime hypoventilation and eventually the need for full-time mechanical ventilation(16).
6. Other diseases
According to the study by Department of Public Health and Clinical Medicine, Umeå University, in restrictive lung function the prevalence of chronic rhinitis, cardiovascular disease, hyperlipemia and diabetes was higher compared to in Nlf (41.0% vs 32.3%, p = 0.017, 59.0% vs 41.0%, p<0.001, 29.2% vs.12.9%, p = 0.033, 20.9% vs 8.6%, p <0.001). In COPD and heart disease, 62.5% had chronic rhinitis and/or GERD, while in Nlf the corresponding proportion was 42.5%(17).
7. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(1)http://oac.med.jhmi.edu/res_phys/Encyclopedia/RestrictVentDefect/RestrictVentDefect.HTML
(11) http://www.ncbi.nlm.nih.gov/pubmed/22212441
(12) http://www.ncbi.nlm.nih.gov/pubmed/23127573
(13) http://thorax.bmj.com/content/35/8/581.full.pdf
(14) http://www.ncbi.nlm.nih.gov/pubmed/1640236
(15) http://www.ncbi.nlm.nih.gov/pubmed/20378598
(16) http://www.ncbi.nlm.nih.gov/pubmed/23137740
(17) http://www.ncbi.nlm.nih.gov/pubmed/22149402

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The alternative Electrostimulation

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).



                            The Treatment


B. Treatment in herbal and traditional Chinese medicine

B.6. The alternative Electrostimulation
Electrostimulation has been applied to acupuncture to treat pain associate to the clips from the therapeutic device, are attached to the needles. This type of alternative application also was found in Ancient Egyptians and later the Greeks and Romans, dates back to thousands of years BC for treatment of pain, muscle dysfunction and sarcopenia(303).
Dr. Men'shikova IV. in the comment of combination of modern physiotherapeutic methods in rehabilitation said,"(Use of electrostimulation of smooth muscle) All patients(with RA) reported alleviation of pain and oedema in the affected joint. The rehabilitation period was 2-5 days shorter than after the traditional treatment(304).In support to the above study, the School of Rehabilitation Sciences, University of Ottawa, in the review of randomized controlled trials (RCTs) and controlled clinical trials (CCTs), case-control and cohort studies comparing ES against placebo or another active intervention in patients with RA showed that electrostimulation (ES) was shown to have a clinically beneficial effect on grip strength and fatigue resistance for RA patients with muscle atrophy of the hand but the evidences were limited due to low methodological quality of the trial included(305).


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(303) Neuromuscular electrostimulation techniques: historical aspects and current possibilities in treatment of pain and muscle waisting by Heidland A1, Fazeli G, Klassen A, Sebekova K, Hennemann H, Bahner U, Di Iorio B.(PubMed)
(304) [Combination of modern physiotherapeutic methods in rehabilitation of patients with osteoarthrosis andrheumatoid arthritis after arthroscopic surgery on the knee joint].[Article in Russian] by Men'shikova IV.(PubMed)
(305) Electrical stimulation for the treatment of rheumatoid arthritis by Brosseau LU1, Pelland LU, Casimiro LY, Robinson VI, Tugwell PE, Wells GE.(PubMed)