The finding of a natural source for treatment of Autosomal recessive polycystic kidney disease has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Autosomal recessive polycystic kidney disease is an inherited diseases(Mutations in the PKHD1)causing abnormal functions of liver and reno inducing morbidity and mortality in children.
Until today, there is no cure, treatment options for autosomal recessive polycystic kidney disease, depending to complications, such as chronic pain.
The smoothie for people with chronic pain in Autosomal recessive polycystic kidney disease
Yield: 2 serving (about 8 ounce each)
1 1/2 cups cherries cups pineapple
1 slice of ginger root
1 cup of peppermint herbal tea
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately
Cherries(1), ginger(4) and peppermint(7) may be the next combination of therapeutic ingredients as pain reliever for treatment of chronic pain in patients with autosomal recessive polycystic kidney disease.
Cherry, a fleshy drupe, is the fruit of many plants of the genus Prunus cultivated all over the world for commercial profit due to its health potential.
In a randomized double-blind crossover study of 58 non-diabetic patients , oral administration of cherry juice improved the Western Ontario McMaster Osteoarthritis Index (WOMAC) scores, inducing the symptom relief, including pain for patients with mild to moderate knee Osteoarthritis, through lowering the C-reactive protein CRP levels(1).According to the Oregon Health & Science University, the study of fifty-four healthy runners with ingest of 355 mL bottles of tart cherry juice twice daily for 7 day, during a strenuous running event can minimize post-run muscle pain(3).
Dr. Kuehl KS said, "Tart cherries appear to possess similar effectiveness in treating the inflammatory reaction seen in both acute and chronicpain syndromes encountered among athletes and non-athletes with chronic inflammatory disease")2) of that may be used as antioxidant and anti-inflammatory ingredient on prevention, treatment, and recovery of soft tissue injury and pain.
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In primary dysmenorrhea patient, ginger is effective on pain relief without inducing adverse effects and may be used as an alternative treatment for primary dysmenorrhea, according to the Mazandaran University of Medical Sciences(4) and treatment of ginger in students with primary dysmenorrhea for 5 days also showed a statistically significant effect on relieving intensity and duration of pain, the Shahed University, study suggested(5).
Furthermore, in osteoarthritic patient, Dr. Therkleson T said," ginger therapy activated a marked relief of osteoarthritis symptoms that progressively improved over the 24 weeks, with no negative effects reported. Ginger therapy needs to be considered by nurses caring for specific personality types with osteoarthritis"(6).
Peppermint is a hybrid mint with small purple or white flowers and downy leaves, in the genus Mentha, belonging to the family Lamiaceae, native to to Europe. The herb has been used in folk medicine as analgesic, antiseptic, antispasmodic, decongestant, agent and to relieve gas, nausea, and stomach pain due to an irritable bowel, intestinal cramps, or indigestion, infecttion, etc
According to the Translational Research Center for Gastrointestinal Disorders (TARGID), peppermint oil, with antispasmodics may be considered as the first-line treatment for abdominal pain in patient with irritable bowel syndrome (IBS)(7).
Menthol, the cooling natural product of peppermint,according to the study conducted by Yale University School of Medicine, is widely used for the relief of acute and inflammatory pain in sports injuries, arthritis, and other painful conditions, through activating the methol induced the sensation of cooling(8).
Dr. Shen YH and Dr. Nahas R. said," Peppermint oil alleviates IBS symptoms, including abdominal pain" and "several complementary and alternative therapies can be recommended as part of an evidence-based approach to the treatment of IBS; these might provide patients with satisfactory relief and improve the therapeutic alliance"(9).
In the 76-year-old woman whose pain had been resistant to standard therapies, application of neat peppermint oil showed to immediately improve in her pain with persistence for 4-6 hours after application of the oil(10).
Taking altogether, People with Chronic Pain due to a
utosomal recessive polycystic kidney diseasen should drink the smoothie as much as they can, depending to digestive and liver toleration.
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References
(1) Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee by Schumacher HR1, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP.(
PubMed)
(2) Cherry juice targets antioxidant potential and pain relief by Kuehl KS1.(
PubMed)
(3) Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial by Kuehl KS1, Perrier ET, Elliot DL, Chesnutt JC.(
PubMed)
(4) The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial by Shirvani MA1, Motahari-Tabari N, Alipour A.(
PubMed)
(5) Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial by Rahnama P1, Montazeri A, Huseini HF, Kianbakht S, Naseri M.(
PubMed)
(6) Ginger Therapy for Osteoarthritis: A Typical Case by Therkleson T1.(
PubMed)
(7) Treatment of abdominal pain in irritable bowel syndrome by Vanuytsel T1, Tack JF, Boeckxstaens GE.(
PubMed)
(8) TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain by Liu B1, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE.(
PubMed)
(9) Complementary and alternative medicine for treatment of irritable bowel syndrome by Shen YH1, Nahas R.(
PubMed)
(10) A novel treatment of postherpetic neuralgia using peppermint oil by Davies SJ1, Harding LM, Baranowski AP.(
PubMed)
