Medical Advisor Journals

Thursday, May 26, 2016

Traditional Chinese Medicine Herbal Therapy - Popular Herbal Ba Jin Tian (Radix Morindae Officinalis)

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Ba jin Tian is also known as morinda root. Morinda is flower plant of genus Morinda in the family Rubiaceae, native in Eastern China. The acrid sweet and warm herb has been used in TCM to infertility, premature ejaculation, spermatorrhea, frequent urination, incontinence, irregular menses, cold and painful lower abdomen as it tonifies the kidney, benefits the yang, release wind and d by promoting the functions of kidney and liver channels.

Ingredients
1. Morindin
2. vitamin C,
3. asperuloside tetraacetate,
4. resin,
5. monotrpein,
6. methyl isoalizarin,
7. methylisoalizarin 1-methylether,
8. rubiadian,
9. rubiadin-1-methyl-ether,
10. 2-methylanthraquinone,
11. 1-hydroxyanthraquinone
11. Etc.

Health benefits
1. 1-hydroxyanthraquinone
The ingredient 1-hydroxyanthraquinone of Ba Jin Tian has bee used as pharmaceutical extraction in treating kidney and bladder stones and as a laxative mixture and mild sedative.

2. Antioxidant
Korean researchers found the Ba Jin Tian may have a antioxidant-actvities in a cell study. It showed a 47.8% 2,2-diphenyl-1-picrylhydrazyl radical scavenging effect in cultured mouse TM3 cells with no significant cytotoxicity.

3. Serotonin
Researchers found that Ba Jin Tian might help treat depression by increasing the effects of hormone serotonin.

4. Resin
Resin, the chemical coumpound in Ba Jin Tain has a anti- inflammartory propetty and is used to treat rheumatism by removing the joint inflammation.

5. Anti tumors
In mice study, researchers found that Bai Jin Tian significantly prolonged the life of mice with implanted tumors (Furusawa et al 2003, Hirazumi et al 1994), by activating the immune systemIt is suggested that this antitumour activity is due to immunostimulatory activity, instead of precipitating in directly cytotoxic to tumour cells.

6. Antimicrobial
In Ducan 1998 vitro study, researchers found that some substances in the Bai Jin Tain contains a anti-microlial property against Escherichia coli.

7. Opsteroporosis
Chemical compounds Anthraquinone from Morinda officinalis have exerted the activity as potential inhibitors of bone resorption, according to the study of “Anthraquinone compounds from Morinda officinalis inhibit osteoclastic bone resorption in vitro” by Bao L, Qin L, Liu L, Wu Y, Han T, Xue L, Zhang Q., posted in PubMed(1).

8. Lung and colon Cancers
three new anthraquinones together with 15 known compounds isolated from the roots of M. citrifolia (Rubiaceae) have shown significant inhibitory effects on the proliferation of human lung and colon cancer cells, according to the study of “Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects” by Lv L, Chen H, Ho CT, Sang S., posted in PubMed(2).

9. Anti -inflamatory activity
CHCl(3)-soluble phase of the root of Morinda citrifolia has proccessed a strong antinociceptive and anti-inflammatory effectswhich are mediated in part by the histamine H(1) receptor, according to the study of “The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active component, damnacanthal, isolated from the root of Morinda citrifolia” by Okusada K, Nakamoto K, Nishida M, Fujita-Hamabe W, Kamiya K, Mizushina Y, Satake T, Tokuyama S., posted in PubMed(3).

(10) Anti-fatigue activity
Three polysaccharides MP-1, MP-2, and MP-3 were isolated from hot water extract of Chinese medicine Morinda officinalis were found to have anti-fatigue activity in mice study, according to the study of “Structural characterization and anti-fatigue activity of polysaccharides from the roots of Morinda officinalis’ By Zhang HL, Li J, Li G, Wang DM, Zhu LP, Yang DP., posted in PubMed(4).

11. Rheumatoid arthritis
The extract of the BuOH of M. officinalis root has shown significantly reduced stretching episodes and prolonged action time in mice and significantly reduced acute paw edema by carrageenan in ratsm as a result of the antinociceptive and anti-inflammatory action of the root, according to the study of “Antinociceptive anti-inflammatory effect of Monotropein isolated from the root of Morinda officinalis” by Choi J, Lee KT, Choi MY, Nam JH, Jung HJ, Park SK, Park HJ., posted in PubMed(5).

12. Diabetes
The crude ethanolic extract have experted the strong activity in reducing the fasting serum glucose levels of the diabetic rats significantly at 150 mg/kg, hepatic and renal TBARS level and significant increasing the hepatic SOD and CAT activities as well as GSH levels. according to the study of “Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats” by Soon YY, Tan BK., posted in PubMed(6).

Side effects
1. Do not use when you have difficulty in urination
2. Do not use combination with salvia root.
3. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21945525
(2) http://www.ncbi.nlm.nih.gov/pubmed/21356281
(3) http://www.ncbi.nlm.nih.gov/pubmed/21212526
(4) http://www.ncbi.nlm.nih.gov/pubmed/19150459
(5) http://www.ncbi.nlm.nih.gov/pubmed/16204945
(6) http://www.ncbi.nlm.nih.gov/pubmed/11993894

The Smoothie of Orange, Yogurt, Ginger herbal Tea for Reduced risk and treatment of Thrush

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for Prevention and treatment of Thrush caused by fungus infection

Thrush (oropharyngeal candidiasis) is a medical condition caused by fungus Candida albicans. Thrush in pregnancy is a condition associated to the infection of the vagina caused by fungus Candida albicans. During pregnancy, as a result of hormone change, cervical fluid has become abundant and thicker to prevent the sperm from entering the cervical canal, leading to high amount of glycogen in the vagina that promotes the growth of bacteria, causing thrush in some women.

You Can Eliminate Osteoarthritis

By addressing the Underlying Causes through Clinical Trials and Studies

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Kyle J. Norton

PubMed

Most common Diseases Free and Longevity of 50 plus - Turmeric Part D By Foods to prevent and treat cancers

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

III. Turmeric
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native totropical South Asia, according to "Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species" by E.W.C. Chan, Y.Y. Lim, S.K. Wong, K.K. Lim, S.P. Tan, F.S. Lianto and M.Y. Yong, posted in Science Direct. It has been used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders. Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red.

D. By Foods to prevent and treat cancers
1. Bone cancer (Osteosarcoma(35%))
Curcumin the main ingredient of turmeric has shown to induce cell apoptosis in human osteosarcoma. Dr. Li Y, and scientists at the Qilu Hospital, Shandong University indicated that curcumin caused marked inhibition of osteosarcoma cell growth and G2/M phase cell cycle arrest. This was associated with concomitant attenuation of Notch-1 and downregulation of its downstream genes, such as matrix metalloproteinases, resulting in the inhibition of osteosarcoma cell invasion through Matrigel. We also found that specific downregulation of Notch-1 via small-interfering RNA prior to curcumin treatment resulted in enhanced inhibition of cell growth and invasion(1).

2. Bone cancer (Chondrosarcoma(25%))
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native to tropicalSouth Asia, Curcumin the main ingredient of turmeric has shown to induce cell apoptosis in human chondrosarcoma. Dr. Lee HP, and scientists at the China Medical University Hospital, found that Curcumin induced upregulation of Fas, FasL, and DR5 expression in chondrosarcoma cells. Transfection of cells with Fas, FasL, or DR5 siRNA reduced curcumin-induced cell death. In addition, p53 involved in curcumin-mediated Fas, FasL, and DR5 expression and cell apoptosis in chondrosarcoma cells. Most importantly, animal studies revealed a dramatic 60% reduction in tumor volume after 21days of treatment(2).

3. Bone cancer (Ewing's sarcoma(16%))
Curcumin is a naturally occurring polyphenolic compound found in the turmeric.Under investigation as a chemotherapeutic and chemopreventive agent in adult cancer models at both pre-clinical and clinical levels. In this preliminary study, showed that curcumin is effective in causing cell cycle arrest, inducing apoptosis, and suppressing colony formation in the Ewing sarcoma cell line SK-NEP-1. Curcumin causes upregulation of cleaved caspase 3 and downregulation of phospho-Akt, producing apoptosis in Ewing sarcoma cells at an inhibitory concentration 50% (IC50) of approximately 4 μM. (3)

4. Cervical cancer
Epidemiological and preclinical evidence suggests that polyphenolicphytochemicals exemplified by epigallocatechin gallate from tea, curcumin from curry and soya isoflavones possess cancer chemopreventive properties. Dr. Thomasset SC and scientists at the University of Leicester, in the review of above showed that the available evidence for tea polyphenols tentatively supports their advancement into phase III clinical intervention trials aimed at the prevention of progression of prostate intraepithelial neoplasia, leukoplakia or premalignantcervical disease. In the case of curcumin and soya isoflavones more studies in premalignacies seem appropriate to optimise the nature and design of suitable phase III trials. The abundance of flavonoids and related polyphenols in the plant kingdom makes it possible that several hitherto uncharacterised agents with chemopreventive efficacy are still to be identified, which may constitute attractive alternatives to currently used chemopreventive drugs(4).

5. Hodgkin's lymphoma
Turmeric, a principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native to tropicalSouth Asia, according to "Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species" by E.W.C. Chan, Y.Y. Lim, S.K. Wong, K.K. Lim, S.P. Tan, F.S. Lianto and M.Y. Yong, posted in Science Direct. It has been used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders. Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red. In the study to to find new therapies that specifically target the deregulated signaling cascades, such as NF-kappaB and STAT3, which causeHodgkin and Reed-Sternberg (H-RS) cell proliferation and resistance of apoptosis, indicated that Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1. Interestingly, curcumin caused cell cycle arrest in G2-M and a significant reduction (80-97%) in H-RS cell viability. Furthermore, curcumin triggered cell death by apoptosis, as evidenced by the activation of caspase-3 and caspase-9, changes in nuclear morphology and phosphatidylserine translocation. The above findings provide a mechanistic rationale for the potential use of curcumin as a therapeutic agent for patients with HL(5).

6. Renal cell carcinoma (Kidney cancer/renal cells)
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione or diferuloyl methane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric.Dr. Kössler S and scientists at the Paracelsus Medical University, in the study of Curcumin affects cell survival and cell volume regulation in human renal and intestinal cells showed that Curcumin exposure induces apoptosis in human kidney cells, and at a concentration of 5.0-10 μM induces the appearance of a sub-population of cells with a dramatically increased volume. In these cells the regulation of the cell volume seems to be impaired, most likely as a consequence of the ICl(swell) blockade. Similarly, 50 μMcurcumin induced apoptosis, caused cell cycle arrest in G1-phase and increased the volume of human colorectal adenocarcinoma HT-29 cells. The cell cycle arrest in G1 phase may be the mechanism underlying the volume increase observed in this cell line after exposure to curcumin(6)

7. Ovarian cancer
a. In the study to analyze the impact of sphingosine kinase-1 (SphK-1) inhibition on ceramides production, and evaluated SphK1 inhibitor II (SKI-II) as a potentialcurcumin chemo-sensitizer in ovarian cancer cells, found that inhibition of SphK1 by SKI-II or by RNA interference (RNAi) knockdown dramatically enhancedcurcumin-induced apoptosis and growth inhibition in ovarian cancer cells. SKI-II facilitated curcumin-induced ceramides production, p38 activation and Akt inhibition. Inhibition of p38 by the pharmacological inhibitor (SB 203580), a dominant-negative expression vector, or by RNAi diminished curcumin and SKI-II co-administration-induced ovarian cancer cell apoptosis, and, to restore Akt activation by introducing a constitutively active Akt (CA-Akt), or to inhibit ceramides production by fumonisin B1 also inhibited curcumin plus SKI-II co-administration-induced in vitro anti-ovarian cancer effect(7).
b. Others found that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3). In addition, p53 knockdown or p53 inhibition did not diminish curcumin killing of HEY cells, confirming p53-independent cytotoxicity. Curcumin also killed OVCA429, and SKOV3 cells grown as multicellular spheroids(7a).

8. Stomach Cancer/Gastric Cancer
Curcumin, a phytochemical compound found in Turmeric has exerted the inhibitory effect against Gastric Cancer. Dr. Sintara K and scientist at the Chulalongkorn University, indicated that curcumin treatments for 3 and 20 weeks reduced thecancer incidence resulting in a decrease of phospho-IκBα expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin treatment for 20 weeks also decreased 8-OHdG expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin can attenuate cancer via a reduction of phospho-IκBα and 8-OHdG expressions, which may play a promising role in gastriccarcinogenesis(8).

9. Skin cancer
In the study of curcumin loaded chitin nanogels (CCNGs) were developed using biocompatible and biodegradable chitin with an anticancer curcumin drug. Chitin, as well as curcumin, is insoluble in water,
indicated that The CCNGs showed a 4-fold increase in steady state transdermal flux of curcumin as compared to that of control curcumin solution. The histopathology studies of the porcine skin samples treated with the prepared materials showed loosening of the horny layer of the epidermis, facilitating penetration with no observed signs of inflammation. These results suggest that the formulated CCNGs offer specific advantage for the treatment of melanoma, the most common and serious type of skin cancer, by effective transdermal penetration(9).

10. Prostate cancer
In the study to examine of a prospective study with 225 incident cases of prostate cancer in 12,395 California Seventh-Day Adventist men who in 1976 stated how often they drank soy milk.
suggests that men with high consumption of soy milk are at reduced risk ofprostate cancer. Possible associations between soy bean products, isoflavones and prostate cancer risk should be further investigated(10).

11. Pancreatic cancer
the study of Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells showed that CUR, NLE, and RSE may serve as effective "deliverables" to potentiate RT in PC cure and further throw light that these phytochemicals-induced cell killing may involve selective regulation of RT-induced NF-κB(11).

12. Pharynx Cancer or pharyngeal cancer
In the study to investigate the mechanism underlying the curcumin-induced apoptosis of nasopharyngeal carcinoma (NPC) cell line NCE cells, indicated that Several evidences of apoptosis were obtained from curcumin-treated NCE cells by acridine orange and ethidium bromide stains, ultrastructure identification, DNA fragmentation assay and TUNEL staining. And the mean TUNEL-positive rates increased significantly at the 3 different time points (12 h, 24 h and 48 h; 25.6%, 40.3% and 54.5%, respectively). In the curcumin-treated-groups, delta psi m altered significantly and the positive rates increased in a time-dependent manner. At the 3 different time points, the mean positive rates were 26.8%, 42.3% and 68.2%, respectively. When caspase-3 activity was detected, 80.5% cells presented proteases activities after 12 h incubation with curcumin. Western Blot analysis showed that cytoplasmic cytochrome C increased significantly after incubation with curcumin. Flow cytometry and RT-PCR analysis showed thatcurcumin could up-regulate the Fas expression in time-depended manner , the positive rates of Fas protein increased from 33.6% to 89.9%(12).

13. Multiple myeloma (Myeloma)
In the study of Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis, scientists at the The University of Texas MD Anderson Cancer Center, showed that Curcumin suppressed the constitutive IkappaBalpha phosphorylation through the inhibition of IKK activity. Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6. This led to the suppression of proliferation and arrest of cells at the G(1)/S phase of the cell cycle. Suppression of NF-kappaB complex by IKKgamma/NF-kappaB essential modulator-binding domain peptide also suppressed the proliferation of MM cells. Curcumin also activated caspase-7 and caspase-9 and induced polyadenosine-5'-diphosphate-ribose polymerase (PARP) cleavage. Curcumin-induced down-regulation of NF-kappaB, a factor that has been implicated in chemoresistance, also induced chemosensitivity to vincristine and melphalan(13).

14. Oral cancer
Curcumin, a major active component and principal curcuminoid of the popular Indian spice of turmeric, ,has been shown to have inhibitory effects on cancers. Dr. Kim JY, and scientists in the study of Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells. indicated that curcumin induced reactive oxygen species (ROS) production and autophagic vacuoles formation bycurcumin was almost completely blocked in the presence of N-acetylcystein (NAC), an antioxidant. Rescue experiments using an autophagy inhibitor suppressed curcumin-induced cell death in OSCC, confirming that autophagy acts as a pro-death signal. Furthermore, curcumin shows anticancer activity against OSCC via both autophagy and apoptosis (14).

15. Melanoma skin cancer
Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red. In the successfully incorporated curcumin into a bilayer of dodecanoic acid attached to magnetite nanoparticles in an effort to maximize solubility and delivery efficiency, found that fluorescent microscopy revealed that curcumin associated magnetite nanoparticles were internalized by the melanoma cells and remained in the cytoplasm. The curcumin/magnetic nanoparticles synthesized in this study possess magnetic and water solubility properties making this a novel curcuminformulation with therapeutic potential(15).

16. Non-Hodgkin's Lymphoma
In the study investigated a novel drug delivery nanovehicle enriched with the bioactive polyphenol, curcumin (curcumin nanodisks; curcumin-ND), showed that cells treated with curcumin-ND showed a dose-dependent increase in apoptosis. This was accompanied by enhanced generation of reactive oxygen species (ROS). The antioxidant, N-acetylcysteine, inhibited curcumin-ND induced apoptosis, suggesting that ROS generation plays a role in curcumin action on MCL cells.Curcumin-ND decreased cyclin D1, pAkt, pIκBα, and Bcl(2) protein. In addition, enhanced FoxO3a and p27 expression as well as caspase-9, -3, and poly(ADP-ribose) polymerase (PARP) cleavage were observed. Curcumin-ND treatment led to enhanced G(1) arrest in two cultured cell models of MCL(16).

17. Leukemia
Curcumin is a phytochemical found abundant in Turmeric. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red. In the study to investigate the anti-cancer effect and action of curcumin on THP-1 cells, showed that Curcumin induced cell apoptosis of THP-1 cells as shown by cell viability, cell cycle analysis and caspase activity. Curcumin significantly increased the phosphorylation of ERK, JNK and their downstream molecules (c-Jun and Jun B). Inhibitor of JNK and ERK reduced the pro-apoptotic effect of curcumin on THP-1 cells as evidenced by caspase activity and the activation of ERK/JNK/Jun cascades. On the contrary, the pro-apoptotic effect of curcumin was abolished in the differentiated THP-1 cells mediated by PMA(17).

18. Etc.

Side effects
1. Overdose may cause gastrointestinal discomfort such as nausea and diarrhea and liver damage.
2. Topical use may be allergic to skin such irritation to certain peoples
3. Do not use the herb in new born, children or if you are pregnant and breast feeding without approval from the related field specialist.
4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22521131
(2) http://www.ncbi.nlm.nih.gov/pubmed/22522053
(3) http://www.ncbi.nlm.nih.gov/pubmed/19859844
(4) http://www.ncbi.nlm.nih.gov/pubmed/17131309
(5) http://www.ncbi.nlm.nih.gov/pubmed/18386790
(6) http://www.ncbi.nlm.nih.gov/pubmed/22178266
(7) http://www.ncbi.nlm.nih.gov/pubmed/22594559
(7a) http://www.ncbi.nlm.nih.gov/pubmed?term=Curcumin%20also%20killed%20OVCA429%2C%20and%20SKOV3%20cells%20grown%20as%20multicellular%20spheroids
(8) http://www.ncbi.nlm.nih.gov/pubmed/22690125
(9) http://www.ncbi.nlm.nih.gov/pubmed/22080352
(10) http://www.ncbi.nlm.nih.gov/pubmed/10189040
(11) http://www.ncbi.nlm.nih.gov/pubmed/21697760
(12) http://www.ncbi.nlm.nih.gov/pubmed/17039805
(13) http://www.ncbi.nlm.nih.gov/pubmed/12393461
(14) http://www.ncbi.nlm.nih.gov/pubmed/22554995
(15) http://www.ncbi.nlm.nih.gov/pubmed/20974686
(16) http://www.ncbi.nlm.nih.gov/pubmed/21699455
(17) http://www.ncbi.nlm.nih.gov/pubmed/22443687

Most common Diseases of 50plus: Obesity and Obesity's complication of Gatroesophageal Reflux Disease (Heart Burn)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is defined as a chronic condition of liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. According to the study of "Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease." by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus.

How Obesity associates with Gatroesophageal Reflux Disease (Heart Burn)
1. According to the study of "Prevalence and risk factors for gastroesophageal reflux disease in an impoverished minority population" by Friedenberg FK, Rai J, Vanar V, Bongiorno C, Nelson DB, Parepally M, Poonia A, Sharma A, Gohel S, Richter JE., posted in PubMed, researchers found that Increasing waist circumference, but not overall body mass index or waist-hip ratio, and smoking are risk factors for prevalent GERD. No association between reflux disease and lifestyle choices such as coffee drinking and fast food dining were found.

2. In a study of "Does BMI affect the clinical efficacy of proton pump inhibitor therapy in GERD? The case for rabeprazole" by Pace F, Coudsy B, Delemos B, Sun Y, Xiang J, Lococo J, Casalini S, Li H, Pelosini I, Scarpignato C., posted inPubMed, researchers comcluded that Results of this study show that the clinical efficacy of rabeprazole is maintained in overweight/obese patients withgastroesophageal reflux disease and suggest that this subgroup of patients may derive, from rabeprazole, even greater benefit than lean patients.

3. In the abstract of the study of "Effects of environment and lifestyle ongastroesophageal reflux disease" by Sonnenberg A., posted in PubMed, researchers stated that Overweight and obesity contribute to the development of hiatal hernia, increase intra-abdominal pressure, and promote gastroesophageal reflux. Weight gain increases reflux symptoms, whereas weight loss decreases such symptoms. Other risk factors, such as smoking, alcohol, dietary fat, or drugs, play only a minor role in shaping the epidemiologic patterns of GERD. PROTECTION THROUGH HELICOBACTER PYLORI: On a population level, a high prevalence of H. pylori infection is likely to reduce levels of acid secretion and protect some carriers of the infection against reflux disease and its associated complications.

4. According to the study of "Gastroesophageal reflux disease and morbidobesity: is there a relation?" by Fisichella PM, Patti MG., posted in PubMed, researchers found that Although many advances have been made in the understanding of the pathophysiology of GERD, many aspects of the pathophysiology of this disease in morbidly obese patients remain unclear. The following review describes the current evidence linking esophageal reflux toobesity, covering the pathophysiology of the disease and the implications for treatment of GERD in the obese patient.

5. In the abstract of the study of "Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms" by Ayazi S, Hagen JA, Chan LS, DeMeester SR, Lin MW, Ayazi A, Leers JM, Oezcelik A, Banki F, Lipham JC, DeMeester TR, Crookes PF., posted in PubMed, researchers found that An increase in body mass index is associated with an increase in esophageal acid exposure, whether BMI was examined as a continuous or as a categorical variable; 13% of the variation in esophageal acid exposure may be attributable to variation in BMI.

6. Etc.

Treatments of Obesity and Gatroesophageal Reflux Disease (Heart Burn)
1. According to the study of "Gastroesophageal reflux disease is inversely related with glycemic control in morbidly obese patients" by Lauffer A, Forcelini CM, Ruas LO, Madalosso CA, Fornari F., posted in PubMed, researchers found that This study suggests an inverse relation between glycemic control and GERD in morbidly obese patients. This can be partially explained by a lower frequency of hiatal hernia in patients with very poor glycemic control.

2. In the study of "Gastroesophageal reflux disease and obesity. Pathophysiology and implications for treatment" by Herbella FA, Sweet MP, Tedesco P, Nipomnick I, Patti MG., posted in PubMed, researchers indicated that A linear regression model showed that BMI, LES pressure, LES abdominal length, and DEA were independently associated with the DeMeester score. These data showed that: (a) BMI was independently associated to the severity of GERD; and (b) in most morbidly obese patients with GERD, reflux occurred despite normal or hypertensive esophageal motility. These findings show that the pathophysiology of GERD in morbidly obese patients might differ from that of nonobese patients, suggesting the need for a different therapeutic approach.

3. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Herbal therapy: Popular Herbal Cramp Bark

(2)http://www.ncbi.nlm.nih.gov/pubmed/17218766
(3) http://www.umm.edu/altmed/articles/menstrual-pain-000052.htm
(4) http://www.livestrong.com/article/96270-stop-menstrual-bleeding/

Most Common Diseases of 50plus: Diabetes - The Symptoms

The Symptoms

If you have the below symptoms, please check with your family doctor. You might have diabetes:
1. Frequent urination
If you feel that you are needing to urinate more often than usual or a compelling urge to urinate, along with discomfort in your bladder. According to the study by Departamento de Ginecologia, Instituto Fernandes Figueira, Fundação Oswaldo Cruz, in the study of seventy-seven patients (13.3%), researchers found that type 2 diabetes was predominant (96.1%). Stress urinary incontinence was the most frequent urodynamic diagnosis (39%) in diabetic patients, followed by detrusor overactivity (23.4%). The prevalence of urodynamic alterations was associated with diabetes (PR=1.31; 95%CI=1.17-1.48). Changes in detrusor contractility (over- or underactivity) were diagnosed in 42.8% diabetic patients and in 31.5% non-diabetic patients(1).

2. Excessive thirst, Unexplained weight loss
The urge to drink too much beyond a certain limit may be a symptom of high blood sugar in your bloodstream , and can be an important clue in detecting diabetes. Loss of body weight can occur due to various conditions ranging from eating disorders to severe metabolic conditions including diabetes. Drastic weight loss of more than 5 to 10 pounds when you’re not trying to, requires medical attention because it may be a sign of diabetes.According to the research team lead by Khan N, in a data on 168 university students (47 males and 121 females) included in the analysis. Of the participants, 25% were overweight or obese and only 27% exercised regularly. Regarding their knowledge of DM, 70% knew that it is characterised by high blood sugar levels and identified family history as a major risk factor. Surprisingly, only just over half could link obesity and physical inactivity as risk factors for developing DM, or could identify an excessive feeling of thirst, frequent urination, and weight loss as symptoms(2).

3. Gastrointestinal symptoms
Diabetes mellitus (DM), such as stomach pain, heartburn, diarrhea, constipation, nausea and vomiting, has been associated with neuronal changes in the enteric, peripheral and/or central nervous system with abnormal visceral sensation and gastrointestinal (GI) symptoms are seen in up to 75% of patients. According to the study by Department of Gastroenterology & Hepatology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Diabetic patients had higher stimulus intensities to evoke painful sensation (p ≤ 0.001), longer latencies of N2 and P2 components (both p ≤ 0.001), and lower amplitudes of P1-N2 and N2-P2 complexes (p ≤ 0.001; p = 0.02). Inverse modelling of brain sources showed deeper bilateral insular dipolar source localization (p = 0.002). Symptom score index was negatively correlated with the depth of insular activity (p = 0.004) and positively correlated with insular dipole strength (p = 0.03)(3).

4. Depression
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate. It is common in people with diabetes, and related to higher HbA(1c) levels(4).

5. Sleeping difficulties, appetite problems and suicidal ideation

If you are experiencing the drive to eat excessively due to emotional and physical causes then it is an emotion disorder that compels you to eat even after you are full. Increased appetite can be an early symptom of diabetes. According to the study conducted in three tertiary diabetes clinics in the Netherlands of a total of 288 out of 646 subjects with diabetes (45%) reported one or more depressive symptom(s). Depressed mood (β = 0.11, P = 0.005), sleeping difficulties (β = 0.16, P < 0.001), appetite problems (β = 0.15, P < 0.001) and suicidal ideation(β = 0.14, P = 0.001) were significantly related to higher baseline HbA(1c) values. Furthermore, depressed mood (β = 0.09, P = 0.03) sleeping difficulties (β = 0.12, P = 0.004), appetite problems (β = 0.11, P = 0.01) and psychomotor agitation/retardation (β = 0.09, P = 0.04) were significantly related to higher HbA(1c) values at 1-year follow-up. Associations were more pronounced in Type 1 diabetes than in Type 2 diabetes(4).

6. Emotion stress
Emotion stress in diabetes patient is associsted to significantly poorer glycaemic control.
Diabetes-distress mediated the relation between depression and glycaemic control and not differently for both disease types. Post-hoc analyses revealed that patients depressed and distressed by their diabetes were in significantly poorer glycaemic control relative to those not depressed nor distressed (HbA(1c) 8.7 +/- 1.7 vs. 7.6 +/- 1.2% in those without depressive symptoms, 7.6 +/- 1.1% in depressed only and 7.7 +/- 1.1% in the distressed only, P < 0.001). Depressed patients without elevated diabetes-distress did not show a significantly increased risk of elevated HbA(1c), according to the study EMGO Institute for Health and Care Research, VU University Medical Centre(5).

7. Vulvovaginal symptoms and Candida colonization
Women with type 2 diabetes mellitus (T2DM) are atgreater risk for vaginal Candida colonization, as a result of glucosuria. In a double-blind study, subjects with T2DM and inadequate glycemic control on metformin were randomized to placebo; canagliflozin 50, 100, 200, 300 mg daily or 300 mg twice daily; or sitagliptin 100 mg daily for 12 weeks, researchers found that 23/198 (12%) females had vaginal cultures positive for Candida (C. glabrata: 14; C. albicans: 5; other: 4), with age ≤55 years associated with increased risk (odds ratio [OR], 3.5; 95% confidence interval [CI], 1.1-10.7)(6).

8. Nonrefractive visual impairment
This is a symptom of great concern. If the blood sugar levels are too high, sugar builds up in your eye, This excess sugar also draws in fluid, changing the shape of the lens and making blurry vision. Certain types of blurry vision can be a medical emergency where delay can lead to loss of sight. In the study to estimate prevalence of nonrefractive visual impairment and to describe its relationship with demographic and systemic risk factors including diagnosed diabetes, showed that prevalence of nonrefractive visual impairment was significantly higher in 2005-2008 than in 1999-2002 and may be attributable, in part, to higher prevalence of diabetes, an associated risk factor that increased in prevalence during this time period(7).

9. Fear, Behavior and Worry
Behavior and Worry scores were positively related to psychological symptoms, perceived stress, and previous experiences with hypoglycemia. Fear was significantly higher for patients who had greater variability and lower mean daily blood glucose, according to the study by University of Virginia Health Sciences Center(8).

10. Reduced awareness
Reduced awareness may be associated to patient with diabetes, depending to experienced hypoglycemia(9).

11. Increased fatigue
Unlike the tiredness experienced by a healthy person, sudden increase of fatigue is a bad thing in people with symptoms of diabetes. Most Type II diabetes are caused by uncontrolled diet that are high in saturated fat. In the case of the cells of the pancreas dying off, experts believe it is caused by excessive drinking of alcohol. According to the study by INRA, Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro), Fatigue is frequent in patients with diabetes and this symptom appears to be more prominent in type 2 rather than type 1 diabetic subjects. Chronic inflammation represents one characteristic of type 2 diabetes that may contribute to fatigue symptoms(10).

12. Slow wound healing
Slow wound healing is associated with poor wound healing in patient with diabetes as a result of weakened immune function. According to Dr. Prosdocimi M, and Dr. Bevilacqua C, the mechanisms underlying tissue repair are altered in the diabetic patient with respect to a healthy individual, namely for a diminished response of the keratinocytes and a reduced capacity of the endothelial cells to form new vessels (neoangiogenesis)(11).

13. Dry skin
In the study to evaluate the efficacy of a new product (Neuropad repair foam(®)) in promoting skin hydration of the foot in type 2 diabetes, found that there was no difference in skin capacitance between right and left foot (P = 0·186). However, skin capacitance was significantly higher on the right versus left foot, both after 7 days (P < 0·001) and after 14 days of treatment (P < 0·001). In conclusion, results with the new foam appear encouraging in ameliorating skin dryness in the diabetic foot(12).

14. Etc.

Traditional Chinese Medicine Herbal Therapy - Popular Herbal Bai Fan or Ming Fan (Alumen)

2. Skin Problem
High concentrations of alum can inhibit the grown of the bacteria that causes acne and pimple.
3. Abdominal uterine prolapse.

Researchers found that 4% extracted Alum concentration used locally has an effect in preventing abdominal uterine prolapse.

4. Vaginal Infection
In In vitro studies, researchers found that concentration of 1o% of Bai Fan have an effectiveness in treating vaginal trichomoniasis.

5. Leukorrhagia
In study, researchers found that 1-5% concentration has an antiperspirant and prevented perspiration properties and suggest that Bai Fan might have an effect in the function of lymphadenitis and perspiration, detoxification.

6. Innate immune responses
Alum enhance the immune response defend the our body from infection by other organisms invasion. without acting as an adjuvant for specific immunity, according to the study of “Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity” by McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P., posted in PubMed(1).

7. Malaria
Potash alum, a traditionally known salt in Indian Ayurveda and Chinese medicine system, have shown the activity in prevnting malaria by acting as a larvicide and growth disruptor, according to the study of “Mosquito larvicidal potential of potash alum against malaria vector Anopheles stephensi (Liston)” by Preet S, Seema KC., posted in PubMed(2).

8. Influenza virus-like particle vaccines
Influenza prevention is always important for the aging population due to age-related weakened immune system. In a study of aging mice, two inflammatory adjuvants, Imject(®) alum (a stimulator of the Nod-like receptor, Nalp3) and poly I:C (a toll-like receptor type 3 ligand), were used during vaccination with novel influenza virus-like particles (VLP). Adult (4 month old) or aged (24 month old) mice were vaccinated with VLPs alone or in combination with adjuvant., conducted by University of Pittsburgh, posted in PubMed(3), researchers found that Influenza VLPs used in combination with two different inflammatory adjuvants during vaccination allow for the immune system to overcome the deficiency in the aged immune system to influenza virus infection.

9. Type 1 diabetes
GAD-alum uased to treat children and adolescents with type 1 diabetes has shown no sign of GAD autoantibody epitope pattern, according to the study of “GAD autoantibody epitope pattern after GAD-alum treatment in children and adolescents with type 1 diabetes” by
Skoglund C, Chéramy M, Casas R, Ludvigsson J, Hampe CS., posted in PubMed(4), researchers wrote thatGAD-alum injections did not affect binding of GADA to SPS-related epitopes, further supporting the safety of the treatment. There were no changes in GADA epitope specificity to the T1D-related epitopes, except for a temporarily increased binding to one of the tested epitopes.

10. H5N1 split-virion vaccine
Alum has shown the property of enhancing the efficacy of an H5N1 split-virion vaccine in the ferret model as measured by immunogenicity, mortality, morbidity, and brain invasion, according to the sudy of “Enhanced immunogenicity, mortality protection, and reduced viral brain invasion by alum adjuvant with an H5N1 split-virion vaccine in the ferret”

Side effects
1. Overdoses of Fai Fan can irritate the mucus membranes
2. Overdose can cause nausea, ulceration, and vomiting.
3. Pregnant women should not take Bai Fan due its cold and toxic nature
4. It can cause depletion of calcium and phosphorus.
5. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19734227
(2) http://www.ncbi.nlm.nih.gov/pubmed/21966124
(3) http://www.ncbi.nlm.nih.gov/pubmed/21963872
(4) http://www.ncbi.nlm.nih.gov/pubmed/21848927
(5) http://www.ncbi.nlm.nih.gov/pubmed/21687736