Medical Advisor Journals

Friday, May 27, 2016

The Blueberry smoothie for Reduced Risk and Treatment of Atypical lobular hyperplasia (ALH) of Fibrosclerosis of breast

Kyle J. Norton(Scholar, Master of Nutrients). All right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for women with high risk of breast cancer, including Atypical lobular hyperplasia (ALH) of Fibrosclerosis of breast
Yield: 2 servings (about 8 ounces each)
1 1/2 cups Blueberries
1 cup rice milk
4-6 ice cubes

1. Place all the ingredients in a blender.
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately.

The dream of finding of a natural ingredient for replacement of serious side effects of chemotherapy for treatment of breast caner has been extremely difficult, probably due to physical differences in testing subjects.

According to the degree of fibroplastic proliferation, proliferative disease of breast can be divided into three types: lobular hyperplasia type, fibroadenosis type and fibrosclerosis type(10)

Where atypical lobular hyperplasia (ALH) is also an abnormal appearing growth of cells within lobules of the breast that is associated with an increased risk of subsequent breast cancer.
According to the Medical University of Vienna, due to the risk of underestimation, surgical excision is often performed. But the analysis of imaging and histopathological characteristics could help identifying low-risk cases, for which surgery is not necessary(11).

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America contains several essential phytochemicals and nutrients, including, lutein and zeaxanthin, zinc, potassium, phosphorus, iron, calcium and vitamins.

Blueberry or whole blueberry powder may hold a key for reduced risk breast cancer and for treatment of the diseases. Recent studies insisted that intake of the fruits and the fruit products showed to the improve the survival rate of women with breast cancer.

In estrogen-mediated breast cancer, blueberry-supplemented diet protect women against breast cancer induced by 17β-estradiol (E2)-mediated mammary tumorigenesis(breast cancer)(1) in animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks study.Dr. Ravoori S and the research team at the University of Louisville suggested, the effectiveness of blue berry for treatment of breast cancer may be a result of the exhibition of its phytochemicals reducing mammary tissue proliferation and tumor burden, tumor latency(2).

In fact the intake of berries reduced significantly mammary tumor incidence (10-30%) by suppressing the levels of E(2) to prevent the early onset of E(2) breast cancer(3).
Dr. Aiyer HS and Gupta RC. said, blueberries and other berries promote anti proliferation and apoptosis of breast cancer cell is due its effects in modulating enzymes of estrogen metabolism.

In breast cancer cell lines MCF7 and MDA-MB-231, pterostilbene, a phytochemical found in blueberries, effectively suppressed tumorigenesis and metastasis of cancer stem cells (CSCs) through reduced expressions in promoted(4) and increased tumor cell proliferation of breast cancer(5).

Addition to that, the joint study lead by the Indian Institute of Technology Roorkee showed that pterostilbene not only expressed itself as a effective inducer of apoptosis in human breast in affecting various cellular targets, it also may be a chemopreventive potential based on its stronger anti-proinflammatory cytokines and anti-inflammatory activities against many forms of diseases(6).

In the study of MCF7, Hs578t and MDA-MB-231 breast cancercell lines, pterostilbene suppressed tumor growth and metastasis in MDA-MB-231, the triple-negative breast cancer and Hs578t cells through inhibition of the migratory and invasive potential by blocking the initiate the metastatic process(7).

Further more, the phytochemical also found to inhibit breast cancer regardless of estrogen receptor (ER-α36 positive or negative breast cancer)status by inducing apoptosis(8) and anti-proliferation(9), with or without the execution of cell death in apoptotic cells(8).

The finding of the effectiveness of blueberry and its phytochemical pterostilbene may serve as a cornerstone of pharmaceutical target for further studies as well as a protential medication for treatment of breast disease.

Women who are at high risk of breast cancer such as genetic mutation genes BRCA1 and BRCA2 should drink at least one cup daily and women with breast cancer should drink the juices as much as they can depending to digestive toleration.

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References
(1) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer by Jeyabalan J1, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC.(PubMed)
(2) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry by Ravoori S1, Vadhanam MV, Aqil F, Gupta RC.(PubMed)
(3) Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism by Aiyer HS1, Gupta RC.(PubMed)
(4) Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit by Mak KK1, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT.(PubMed)
(5) Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression by Vesuna F1, Lisok A, Kimble B, Raman V.(PubMed)
(6) Understanding the mode of action of a pterostilbene derivative as anti-inflammatory agent by Nikhil K1, Sharan S1, Palla SR2, Sondhi SM2, Peddinti RK2, Roy P3.(PubMed)
(7) Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition by Su CM1, Lee WH2, Wu AT3, Lin YK4, Wang LS5, Wu CH6, Yeh CT7.(PubMed)
(8) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)
(9) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)

(10) [Studies on the histological classification of proliferative disease of breast and its relation with breast carcinoma].[Article in Chinese] by Zhang J1, Liu H, Liu B.(PubMed)

(11) Management of atypical lobular hyperplasia, atypical ductal hyperplasia, and lobular carcinoma in situ by Clauser P1, Marino MA1, Baltzer PA1, Bazzocchi M2, Zuiani C2.(PubMed)

Most common Diseases Free and Longevity of 50 plus - Organic Soy(The Articles) Soy and cancers in Japan population

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)

The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.

Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".

Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein

I. The Articles(The Japanese population)
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).

Soy and cancers in Japan population

Cancer, is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, become progressively worse and damaged other healthy tissues and sometimes spread to other organs in the body via lymph or blood and results may be in death.

Epidemiological studies, linking soy and soy products in reduced risk and treatment have been contradictive(1)(2)(3)(4), but in Japanese population, soy and its products have been found effectively in reduced risks of and treatment of cancers, it may be result of equol producer status or long term exposure since childhoods. Some researchers suggested that it may be result of traditional Japanese diet with high in soy, vegetables, fish.

1. Breast cancer
Breast cancer (malignant breast neoplasm) is a cancer started in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) which supply the ducts with milk. There is also rare cases that breast cancer starts in other areas of the breast.
According to the evaluation based on a systematic review of epidemiologic evidence among the Japanese population, there is no associated of intakes of individual soy foods with the risk of breast cancer but evidence supported the biological plausibility of a protective effect of isoflavones on breast cancer risk(5). The study in the testing of oral administration of IF-rich tablet (20 and 40 mg/day) on climacteric women, showed the product not only reduced risk of breast cancer but also improved of bone density, hypertension and climacteric symptoms, cardiovascular diseases, gynecological problems and possible immune potentiation(6)
Japanese women have lower incidence of and mortality from breast cancer, compared to Caucasians, it may be result of large amount intake soy protein and isoflavones, as high dietary intake of phytoestrogens, mainly in the form of soyproducts, can produce circulating levels of phytoestrogens that are known experimentally to have oestrogenic effects(7).

2. Lung cancer
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.
Soy intakes are associated to reduced risk of lung cancer with epidermal growth factor receptor (EGFR) mutations which play substantial roles in genesis and proliferation of non-small-cell lung cancers (NSCLCs), according to the Aichi Cancer Center Research Institute.(8). In Asian populations, not only Japanese, in the review of total of 11 epidemiological studies that consisted of 8 case-control and 3 prospective cohort studies, although consumption of soy food is associated with lower lung cancer risk, intervention studies that use unified measures of soyintake are needed to fully characterize such an association due to different methods used to assess soy consumption across reviewed studies(9).
In deed, isoflavone intake was associated with a decreased risk of lung cancer in never smokers, but not in current or past smokers, according to a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999, conducted by the NationalCancer Center Tokyo Japan(10).

3. Bowel (Colorectal ) Cancer
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including US and Canada.
According to the Research Center for Cancer Prevention and Screening, NationalCancer Center in Japan, in investigated association between dietary soy and isoflavone intake and incidence of colorectal cancer in a prospective cohort study of 83,063 Japanese men and women, ages 45 to 74 years, intake of isoflavones, miso soup, and soy food was not associated with colorectal cancer in either men or women. By colorectal cancer subsite, the risk of proximal colon cancer in men decreased with increasing consumption of isoflavones, miso soup, and soy food in Compared with men in the lowest quartiles of isoflavones(11) and high isoflavone intake was associated with reduced risk of CI and MI in Japanesewomen, especially in postmenopausal women(12).
But for patients with Acromegaly, a syndrome that results when the anterior pituitary gland produces excess growth hormone (GH), the risk of colorectal cancer is increased substantially(13)(14).

4. Gastric cancer
Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
According to the National Cancer Center, Goyang, Korea, high level of consumption of non-fermented soy foods, rather than fermented soy foods, is associated to reducing GC risk, in the reviews of 20 studies assessing the effect of the consumption of fermented soy food on GC risk(15).
4-hydroxy-2 (or 5)-ethyl-5 (or 2)-methyl-3(2H)-furanone (HEMF), a chemical constituent from of Japanese-style fermented soy sauce, reduced hydrogen peroxide concentration in human polymorphonuclear leucocytes stimulated by arachidonic acid or 12-O-tetradecanoylphorbol-13-acetate,through inhibition of carcinogenesis in this system by acting at the post-initiation stage, in female rats(16). Long-term effect of shoyu (Japanese soy sauce), in rat study did not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity but with a mild gastritis(17).

5. Cancer of Endometrium/Endometrial Cancer
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
Greater consumption of isoflavone-containing foods is associated with a reduced risk of endometrial cancer in this population of nonhysterectomized postmenopausal women(18).
In support to the above, the University of Hawaii, in the study of Endometrial cancer cases (n = 332) diagnosed between 1985 and 1993 which were identified from the five main ethnic groups in the state (Japanese, Caucasian, Native Hawaiian, Filipino, and Chinese) through the rapid-reporting system of the Hawaii Tumor Registry, showed that plant-based diets low in calories from fat, high in fiber, and rich in legumes (especially soybeans), whole grain foods, vegetables, and fruits reduce the risk of endometrial cancer(20). According to the NationalCancer Center, Tokyo, Japan, in the study of Forty nine thousand one hundred and twenty-one women of age 45-74 years who responded to a 5-year follow-up survey, researchers found that there was no evidence of a protective association betweensoy food or isoflavone intake and endometrial cancer risk(19).

6. Cervical Cancer
Cervix is the lower part of uterus that opens at the top of the vagina. Cervix acts an transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus. Cervical cancer is malignantneoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.
According to the study by, there was a the marginally significant inverse association between CIN3 and tofu and green leafy vegetables among Japanese women(21).

7. Prostate cancer
See The Science of Soy - The East Viewpoints: Part A3 - Soy and Prostate Cancer in Japanese Men

8. Thyroid Cancer
Thyroid is one of the largest endocrine glands found in the neck, below the Adam's Apple with the function of regulating the body use of energy, make of proteins by producing its hormones as a result of the stimulation of thyroid-stimulating hormone (TSH) produced by the anterior pituitary.
Thyroid cancer is defined as condition in which the cells in the thyroid gland have become cancerous.
According to the National Institute of Health Sciences, Tokyo, Japan, in the evaluation of the proliferating cell nuclear antigen labeling indices elevated in the ID diet(iodine-deficient diet) Female F344 rat groups suggest that isoflavones may not be involved in the mechanisms underlying the synergistic goitrogenic effect of soybean with iodine deficiency(22) but the study by showed the positive effect of dietary defatted soybean in synergistically stimulated the growth of rat thyroid with iodine deficiency, partly through a pituitary-dependent pathway(23). No study was found in the search of the key word - soy and thyroid cancer in Japanese population" in PubMed).

Taken altogether, Soy and its by products may be association to reduce risk and for treatment certain cancers in Japanese population, including breast, lung, bowel, gastric, prostate, endometrial, cervical cancers, etc. Due to lack of qualities of the studies found in PubMed, further study may be necessary to improve its validation even in Japanese population. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
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References
(1) Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model by Andrade JE1, Ju YH, Baker C, Doerge DR, HelferichWG.(PubMed)
(2) Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations by Ju YH1, Allred KF, Allred CD, Helferich WG.(PubMed)
(3) Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth by Gaete L1, Tchernitchin AN, Bustamante R, Villena J, Lemus I, Gidekel M, Cabrera G, Astorga P.(PubMed)
(4) The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soyisoflavone genistein by Pabona JM1, Dave B, Su Y, Montales MT, de Lumen BO, de Mejia EG, Rahal OM, Simmen RC.(PubMed)
(5) Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population by Nagata C1, Mizoue T, Tanaka K, Tsuji I, Tamakoshi A, Matsuo K, Wakai K, Inoue M, Tsugane S, Sasazuki S; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan(PubMed)
(6) Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation by Watanabe S1, Uesugi S, Kikuchi Y.(PubMed)
(7) Phytoestrogens and breast cancer--promoters or protectors? by Rice S1, Whitehead SA.(PubMed)
(8) Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese by Matsuo K1, Hiraki A, Ito H, Kosaka T, Suzuki T, Hirose K, Wakai K, Yatabe Y, Mitsudomi T, Tajima K.(PubMed)
(9) Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies by Yang WS1, Va P, Wong MY, Zhang HL, Xiang YB.(PubMed)
(10) Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan by Shimazu T1, Inoue M, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S; Japan Public Health Center-based Prospective Study Group.(PubMed)
(11) Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study by Akhter M1, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S; Japan Public Health Center-Based Prospective Study Group(PubMed)
(12) Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I by Kokubo Y1, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S; JPHC Study Group.(PubMed)
(13) The prevalence and associated factors of colorectal neoplasms in acromegaly: a single center based study by Yamamoto M1, Fukuoka H, Iguchi G, Matsumoto R, Takahashi M, Nishizawa H, Suda K, Bando H, Takahashi Y.(PubMed)
(14) Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels by Matano Y1, Okada T, Suzuki A, Yoneda T, Takeda Y, Mabuchi H(PubMed)
(15) Fermented and non-fermented soy food consumption and gastric cancer inJapanese and Korean populations: a meta-analysis of observational studies by Kim J1, Kang M, Lee JS, Inoue M, Sasazuki S, Tsugane S.(PubMed)
(16) Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia and reduction of H2O2 concentration in human polymorphonuclear leucocytes by flavour components of Japanese-style fermented soy sauce by Kataoka S1, Liu W, Albright K, Storkson J, Pariza M.(PubMed)
(17) Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat by MacDonald WC, Dueck JW.(PubMed)
(18) Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study by Ollberding NJ1, Lim U,Wilkens LR, Setiawan VW, Shvetsov YB, Henderson BE, Kolonel LN, Goodman MT.(PubMed)
(19) Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study by Budhathoki S1, Iwasaki M, Sawada N, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S; JPHC StudyGroup(PubMed)
(20) Association of soy and fiber consumption with the risk of endometrial cancer by Goodman MT1, Wilkens LR, Hankin JH, Lyu LC, Wu AH, Kolonel LN.(PubMed)
(21) Association between dietary calcium and vitamin D intake and cervicalcarcinogenesis among Japanese women by Hosono S1, Matsuo K, Kajiyama H, Hirose K, Suzuki T, Kawase T, Kidokoro K, Nakanishi T, Hamajima N, Kikkawa F, Tajima K, Tanaka H.(PubMed)
(22) Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet by Son HY1, Nishikawa A, Ikeda T, Imazawa T, Kimura S, Hirose M.(PubMed)
(23) Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia by Ikeda T1, Nishikawa A, Imazawa T, Kimura S, Hirose M.(PubMed)

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(1) "A randomized trial of a hypocaloric high-protein diet, with and without exercise, on weight loss, fitness, and markers of the Metabolic Syndrome in overweight and obese women" by Meckling KA, Sherfey R., posted in Pubmed

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Herbal therapy: Popular Herbal Dandelion(Taraxacum officinale)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Dandelion

Dandelion is a herbaceous perennial plant, genus Taraxacum, beloning to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure and heart weakness, chronic joint, skin diseases, etc.

Health Benefits
1. HIV-1
In the evaluation of aqueous dandelion extract and it effects on Acquired immunodeficiency syndrome (AIDS), which is caused by the human immunodeficiency virus (HIV), found that The dandelion extract showed strong activity against HIV-1 RT and inhibited both the HIV-1 vector and the hybrid-MoMuLV/MoMuSV retrovirus replication, according to the study of "Inhibitory effect of aqueous dandelion extract on HIV-1 replication and reverse transcriptase activity" by Han H, He W, Wang W, Gao B.(1)

2. Hepatoprotective effects
In the study of a poly-phytocompound EH-1501 (containing grape leaf, wild strawberry, dandelion and milk thistle, EuroHealth, Italy) and it effects on chronic fibrotizing liver injury, found that " EH-1501 showed a significantly higher degree of gene down-regulation as compared to silymarine (p < 0.05). Taken altogether, these data suggest that a natural antioxidant-containing phytocompound EH-1501 exerts an effective hepatoprotective property in experimental chronic fibrotizing liver injury to a significantly higher degree than silymarin, according to "Hepatoprotective activity of a phytotherapeutic formula on thioacetamide--induced liver fibrosis model" by Kantah MK, Kobayashi R, Sollano J, Naito Y, Solimene U, Jains S, Catanzaro R, Minelli E, Polimeni A, Marotta F.(2)

3. Digestion-enhancing properties
In the analyzing the traditional societies' plant lore and their effects in treating digestive disturbances and ailments found that plants belong to one of three groups: bitter, aromatic and pungent plants, including ginger, peppermint, aniseed and fennel, citrus fruits, dandelion and artichoke, melissa and chamomile have a substantial body of data in support of their digestion-enhancing activities, according to the study of "Functional foods with digestion-enhancing properties" by Valussi M.(3)

4. Anti-inflammatory effects
In the analyzing luteolin and chicoric acid, two abundant constituents of the common dandelion and their anti-inflammatory effects found that luteolin plays a central role in ameliorating LPS-induced inflammatory cascades via inactivation of the NF-κB and Akt pathways, and that chicoric acid strengthens the anti-inflammatory activity of luteolin through NF-κB attenuation, according to the study of "Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-κB translocation in LPS stimulated RAW 264.7 cells" by Park CM, Jin KS, Lee YW, Song YS.(4)

5. Diuretic effect
In the observation of high-quality fresh leaf hydroethanolic extract of the medicinal plant T. officinale (dandelion) and its Diuretic effect found that there was a significant (p < 0.05) increase in the frequency of urination in the 5-hour period after the first dose. There was also a significant (p < 0.001) increase in the excretion ratio in the 5-hour period after the second dose of extract. The third dose failed to change any of the measured parameters, according to "The diureticeffect in human subjects of an extract of Taraxacum officinale folium over a single day" by Clare BA, Conroy RS, Spelman K.(5)

6. Diabetes
in the research of aqueous extracts and their effect on alpha-glucosidase inhibitory activity found that Urtica dioica, Taraxacum officinale, Viscum album, and Myrtus communis with alpha-glucosidase inhibitor activity was conducted to identify a prophylactic effect for diabetes in vitro. All plants showed differing potent alpha-glucosidase inhibitory activity, according to the study of "Inhibition of alpha-glucosidase by aqueous extracts of some potent antidiabetic medicinal herbs' by Onal S, Timur S, Okutucu B, Zihnioğlu F.(6)

7. Hepatoprotective effects
In the investigation of Taraxacum officinale (dandelion) root against alcoholic liver damage were investigated in HepG2/2E1 cells and ICR mice found that ethanol plus hot water extract (TOH) from T. officinale root exhibited significant increases in hepatic antioxidant activities, including catalase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, and glutathione. Furthermore, the amelioration of malondialdehyde levels indicated TOH's protective effects against liver damage mediated by alcohol in vivo, according to the study of "In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacumofficinale (dandelion) root against alcohol-induced oxidative stress" by You Y, Yoo S, Yoon HG, Park J, Lee YH, Kim S, Oh KT, Lee J, Cho HY, Jun W.(7)

8. Antifungal activity
In the analyzing seeds of 2S albumins of dandelion and it Antifungal effects found that dandelion 2S albumins possess inhibitory activity against phytopathogenic fungi and the oomycete Phytophtora infestans at micromolar concentrations with various isoforms differing in their antifungal activity. Thus, 2S albumins of dandelion seeds represent a novel example of storage proteins with defense functions, according to the study of "Antifungal activity of storage 2S albumins from seeds of the invasive weed dandelion Taraxacum officinale Wigg" by Odintsova TI, Rogozhin EA, Sklyar IV, Musolyamov AK, Kudryavtsev AM, Pukhalsky VA, Smirnov AN, Grishin EV, Egorov TA.(8)

9. Etc.

Side effects
1. Overdoses of Taraxacum officinale may increase the risk of male infertility, as a result of aqueous extract, according to the study of "Dandelion (Taraxacumofficinale) decreases male rat fertility in vivo" by Tahtamouni LH, Alqurna NM, Al-Hudhud MY, Al-Hajj HA.(a)
2. Dandelion may cause allergic reaction
3. Do not use the herb, if you have obstruction of the bile ducts
4. Do not use the herb if you are pregnant or breast feeding with out approval of related field specialist
5. Overdoses may cause gastrointestinal discomfort
6. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22078030
(2) http://www.ncbi.nlm.nih.gov/pubmed/22069962
(3) http://www.ncbi.nlm.nih.gov/pubmed/22010973
(4) http://www.ncbi.nlm.nih.gov/pubmed/21513709
(5) http://www.ncbi.nlm.nih.gov/pubmed/19678785
(6) http://www.ncbi.nlm.nih.gov/pubmed/15704495
(7) http://www.ncbi.nlm.nih.gov/pubmed/20347918
(8) http://www.ncbi.nlm.nih.gov/pubmed/19594427

(a) http://www.ncbi.nlm.nih.gov/pubmed/21354287

The Best Smoothie of Folium Pyrrosiae Tea, Vitamin D Fortified Low Fat Milk and Avocado for Prevention and Treatment of urinary track infection caused by Medullary sponge kidney

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Medullary sponge kidney is a contingent disorder of kidney disease resulted of cystic dilatation of the collecting tubules in one or both kidneys, leading to increased risk of forming of kidney stone and urinary track infection. Most Medullary sponge kidney can be treated by minimally invasive percutaneous nephrolithotomy in the treatment of medullary sponge kidney patients with complex renal calculi(*).

The smoothie for reduced risk and treatment of Urinary track infection caused by Medullary sponge kidney
Yield: 2 servings (about 8 ounces each)
1/2 cup avocado
3/4 cup vitamin D fortified low fat milk
1 cup Folium Pyrrosiae tea(Make from 7.5 grams of Shi Wei leave boiled in a cup of hot water for 10 minutes, then add 1.5 grams green tea for 1 more minute and let cool to room temperature

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for reduced symptoms and treatment of Urinary track infection is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine. Unfortunately, many compounds found effective in initial studying failed to confirm the potentials in large sample size and multi center.
Urinary track infection is an infection of any part of your urinary system, including kidneys, ureters, bladder and urethra. It is said that urinary tract infection causes oxidative stress, increases lipid peroxidation level, and leads to insufficiency of antioxidant enzymes(6).

Vitamin E, found abundantly in avocado, a fat soluble and powerful antioxidant vitamin, may be used for treatment of urinary track infection caused by kidney diseases(1). According to the Arak University of Medical Sciences, Vitamin E supplementation has a significant effect in ameliorating sign and symptoms of UTI(1).
Dr. Mandracchia D and research team of the joint study led by the University of Pavia said, " Synthesis and characterization of innovative inulin (INU)-vitamin E succinate (VITE) bioconjugates (INVITE) may be used as new drug delivery systems (DDS) for the therapy of urinary tract infections (UTI)"(2).

Vitamin D, anther fat soluble free radical scavenger, if deficient, is associated to increased risk of urinary tract infections(3). According to the Leiden University Medical Center, vitamin D insufficient promote the expression of pro inflammatory cytokines IL-6, IL-8, and LL37 and microbial proteins in patients with urinary track infection(4). The vitamin is also found effectively in exhibition of anti Escherichia coli infection through immune modulation effect in induced urinary track infection(5).

Folium Pyrrosiae tea containing Folium Pyrrosiae and green tea may also be used for treatment of urinary track infection(7). According to Guang' anmen Hospital Affiliated to China Academy of Chinese Medical Sciences, in the treatment of 147 upper UTI cases and the 312 lower UTI cases, Compound Shiwei Tablet (CST) display significantly therapeutic efficacy on UTI and is safe in clinical application(8).

The combination of Folium Pyrrosiae Tea, Vitamin D Fortified Low Fat Milk and Avocado smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of hydronephrosis caused by Kidney Stones without inducing adverse effects.

People who are at increased risk of urinary track infection due to kidney diseases, family history .....should drink at least one cup daily and people with urinary track infection caused by Medullary sponge kidney should drink the juices at least 4 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

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References
(1) Vitamin E as adjuvant treatment for urinary tract infection in girls with acute pyelonephritis by Yousefichaijan P, Kahbazi M, Rasti S, Rafeie M, Sharafkhah M1.(PubMed)
(2) Amphiphilic inulin-D-α-tocopherol succinate (INVITE) bioconjugates for biomedical applications by Mandracchia D1, Tripodo G2, Latrofa A3, Dorati R2.(PubMed)
(3) Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants by Kwon YE1, Kim H, Oh HJ, Park JT, Han SH, Ryu DR, Yoo TH, Kang SW.(PubMed)
(4) Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants by Kwon YE1, Kim H, Oh HJ, Park JT, Han SH, Ryu DR, Yoo TH, Kang SW.(PubMed)
(5) The impact of vitamin D on the innate immune response to uropathogenic Escherichia coli during pregnancy by Ramos NL1, Sekikubo M2, Kironde F3, Mirembe F4, Sääf M5, Brauner A6.(PubMed)
(6) The Effects of Oxidative Stress in Urinary Tract Infectio by Ergul Belge Kurutas,1,* Pınar Ciragil,2 Mustafa Gul,2 and Metin Kilinc(PMC)
(7) Chinese Medicinal Teas: Simple, Proven, Folk Formulas for Common Diseases By Xiao-fan Zong, Gary Liscum
(8) [Clinical observation on effect of compound Shiwei Tablet in treating urinary tract infection].
[Article in Chinese] by Zhan YL1, Li XY, Wu SX.(PubMed)

Food Therapy: Whole Grains - Buckwheat

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Buckwheat

Buckwheat is genus Fagopyrum, belong to Family Polygonaceae. It is not related to any other wheat, and consequently is an excellent rotation crop in small grain cropping systems. Buckwheat is adapted to a wide variety of soils and climates, and now is available throughout the year and can be served as an alternative to other whole grains.

Nutrients
1. Protein
2. Carbohydrate
3. Dietary fiber
4. Vitamin B1
5. Vitamin B2
6. Vitamin E
6. Phosphorus
7. Magnesium
8. Copper
9. Iron,
10.calcium and
11.Selenium
12. Manganese
13. Zinc
14. Etc.

Health benefits
A. Health benefits according to the studies
1. Antioxidant activity
in the investigation of buckwheat samples (Xingku No.2 and Diqing) grown at three locations were analyzed for free and bound phenolic content and its antioxidant effects found that additionally, growing conditions and the interaction between variety and environment may have more contribution than variety to individual phenolics and antioxidant properties of tartary buckwheat. Environmental parameters such as higher altitudes may also have an increasing effect on rutin and phenolic acids. according to "Phenolics content and antioxidant activity of tartary buckwheat from different locations" by Guo XD, Ma YJ, Parry J, Gao JM, Yu LL, Wang M.(a)

2. Anti-fatigue properties
In the evaluation of tartary buckwheat extracts (TBE) and its anti-fatigue effect found that tartary buckwheat extracts had anti-fatigue properties, which extended the exhaustive swimming time of mice, effectively inhibiting the increase of BLA, decreasing the level of BUN, increasing the tissue glycogen content and the activities of SOD and GPx of mice, according to "Anti-fatigue properties of tartary buckwheat extracts in mice" by Jin HM, Wei P.(b)

3. Anti pathogenic bacteria and insulin resistance effects
In the observation of d-Fagomine, an iminosugar found seeds of buckwheat and its anti pathogenic bacteria and insulin resistance effects found that d-fagomine significantly (P < 0·001) inhibited the adhesion of Enterobacteriaceae (95-99 % cells in the supernatant) and promoted the adhesion of Lactobacillus acidophilus (56 % cells in the supernatant) to intestinal mucosa. d-Fagomine did not show any effect on bacterial cell viability. Based on all this evidence, d-fagomine may be used as a dietary ingredient or functional food component to reduce the health risks associated with an excessive intake of fast-digestible carbohydrates, or an excess of potentially pathogenic bacteria, according to the study of "d-Fagomine lowers postprandial blood glucose and modulates bacterial adhesion" by Gómez L, Molinar-Toribio E, Calvo-Torras MA, Adelantado C, Juan ME, Planas JM, Cañas X, Lozano C, Pumarola S, Clapés P, Torres JL.(c)

4. Myeloperoxidase and cholesterol
In the investigation of investigated of the intake of common buckwheat (low rutin content) and tartary buckwheat cookies (high rutin content) on selected clinical markers found that intake of tartary buckwheat cookies with high level of the antioxidant rutin may reduce levels of MPO, an indicator of inflammation. Moreover, intake of both types of buckwheat cookies may lower cholesterol levels, according to the study of "Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: a double blind crossover study in day-care centre staffs" by Wieslander G, Fabjan N, Vogrincic M, Kreft I, Janson C, Spetz-Nyström U, Vombergar B, Tagesson C, Leanderson P, Norbäck D.(d)

5. Antidiabetic effects
In the examination of buckwheat sprouts (BS) (Fagopyrum esculentum Moench) on lipid and carbohydrate metabolism found that BS have various in vivo activities in relation to antidiabetic effects in type 2 diabetic mice, especially for improvement in lipid metabolism. It was deduced that excretion of bile acids in feces by feeding the BS diet would contribute to the suppression of the cholesterol concentration in the plasma and liver tissues of mice, according to "Effects ofbuckwheat sprouts on plasma and hepatic parameters in type 2 diabetic db/db mice" by Watanabe M, Ayugase J.(e)

6. Etc.

B. Health benefits according to the concentration
1. Manganese
It is one of important trace in preventing osteoporosis, according to the study of "[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]" by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(1)and regulating blood sugar level, according to the study of "[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]" by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(2)

2. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(3)

3. Magnesium
Magnesium not only important for bone health, according to the study of "Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis?" by Odabasi E, Turan M, Aydin A, Akay C, Kutlu M(3) but also play and important role in protecting against Alzheimer's disease, according to the study of "Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease" by Barbagallo M, Belvedere M, Di Bella G, Dominguez LJ.(4)

4. Etc.

C. Other health benefits
1. Flavonoids
one of many plant antioxidant that only increases the immune system in protect our body against the the progression of cancer-promoting hormones attaching to healthy cells, but also destroys, as a result protecting cells in DNA replication, according to the study of "Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer" by Prasad S, Phromnoi K, Yadav VR, Chaturvedi MM, Aggarwal BB., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20635307) researchers found that The present review describes various flavones, flavanones, flavonols, isoflavones, anthocyanins, and chalcones derived from fruits, vegetables, legumes, spices, and nuts that can suppress the proinflammatory cell signaling pathways and thus can prevent and even treat the cancer.

2. Oxidation
Buckwheat contains a measure amount of flavonoids if used combination with vitamin E, it not only can increase the immune system in neutralizing the forming of dangerous free radicals but also fight against free radicals cause of cells damage, according to the study of "Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen" by Carneiro CD, Amorim JC, Cadena SM, Noleto GR, Di Mascio P, Rocha ME, Martinez GR, posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20561949), researchers indicated that compounds, such as flavonoids, may affect the product distribution of (1)O(2)-mediated oxidation of dGuo, and, in particular, high concentrations of flavonoids with hydroxyl groups in their structure lead to an increase in the formation of the mutagenic lesion 8-oxodGuo.

3. Diabetes
Since buckwheat contains high amount of fiber, it not only protect the large intestine against constipation, but also reduces the risk of adult-onset diabetes. by decreasing the stress of pancreas in insulin production as it releases the glucose into blood stream slowly. according to the study of "High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women" by Juntunen KS, Laaksonen DE, Poutanen KS, Niskanen LK, Mykkänen HM., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/12540398), reserachers found that High-fiber rye bread appears to enhance insulin secretion, possibly indicating improvement of b cell function.

4. Atherosclerosis
Since it contain high amount of magnesium, that only helps regulate blood sugar, maintains healthy nerve function and keeps the bones strong, but also enhances the immune system in fighting against cholesterol oxidation, thus decreasing the risk of plague accumulated on the arterial walls, leading to heart diseases and stroke, according to the study of "Serum and dietary magnesium and risk of ischemic stroke: the Atherosclerosis Risk in Communities Study" by
Ohira T, Peacock JM, Iso H, Chambless LE, Rosamond WD, Folsom AR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/19372211), researchers found that Dietary magnesium intake was marginally inversely associated with the incidence of ischemic stroke (P(trend) = 0.09). Low serum magnesium levels could be associated with increased risk of ischemic stroke, in part, via effects on hypertension and diabetes.

5. Prostate health
Since it contains a measure amount of zinc, the mineral is necessary to maintain a healthy prostate in production of seminal fluid and quality sperm, thus decreasing the risk of sexual important and infertility, according to the study of 1,320 men over the age of 40 in the 2001-2002 National Health and Nutrition Examination Survey (NHANES)., posted in Pubmed (http://www.ncbi.nlm.nih.gov/pubmed/18044729%29researchers concluded that a protective effect of zinc intake on cadmium-induced prostatic injury, and may provide further rationale for investigating the impact of these factors individually and jointly on the etiology of prostate cancer.

6. Etc

Side effect