Medical Advisor Journals

Tuesday, May 31, 2016

Most common Diseases Free and Longevity of 50 plus - Organic (Whole Food) Soy Part B By the world most healthy herbs

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)

The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.

Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".

Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein

B. By the world most healthy herbs
1. Insulin sensitive
Soybean helps to normalize plasma glucose and insulin homeostasis, according to "Increased insulin sensitivity and changes in the expression profile of key insulin regulatory genes and beta cell transcription factors in diabetic KKAy-mice after feeding with a soy bean protein rich diet high in isoflavone content" by Nordentoft I, Jeppesen PB, Hong J, Abudula R, Hermansen K.(1)

2. Cardiovascular diseases
Soy protein reduces reduces the levels of serum lipoprotein, decrease in low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), LDL-C/high-density lipoprotein cholesterol (HDL-C), triacylglycerol/HDL-C and TC/HDL-Cpostmenopausal women are at risk of cardiovascular disease, according to "Effects of soy bean on serum paraoxonase 1 activity and lipoproteins in hyperlipidemic postmenopausal women" by Shidfar F, Ehramphosh E, Heydari I, Haghighi L, Hosseini S, Shidfar S.(2)

3. Adipogenesis and Adipolysis
Germinated soy bean protein hydrolysates had an effect on inhibition of lipid storage in adypocites and increasing lipolysis, according to "Effect of Germinated Soybean Protein Hydrolysates on Adipogenesis and Adipolysis in 3T3-L1 Cells" by González-Espinosa de Los Monteros LA, Ramón-Gallegos E, Torres-Torres N, Mora-Escobedo R.(3)

4. Antioxidant effects
Extract from Virginia-grown soybean seeds had exerted its antioxidant effect when compared for their total phenolic contents (TPC), oxygen radical absorbance capacity (ORAC), and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(*)) scavenging activities, according to "Comparison of different strategies for soybeanantioxidant extraction" by Chung H, Ji X, Canning C, Sun S, Zhou K.(4)

5. Diabetes and hypertension
Soybean phenolic-rich extracts has exerted the inhibitory activities of phenolic-rich extracts from soybean on α-amylase, α-glucosidase and angiotensin I converting enzyme (ACE) activities in vitro, according to "Soybean phenolic-rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro" by Ademiluyi AO, Oboh G.(5)

6. Aspartic acid
Aspartic acid not only helps to protect the body from drug toxicity and radiation, it also plays an essential role for the brain in information transmitting across the synapse, thus enhancing the learning and memory mechanism, according to the study of "Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific" byOrmond J, Woodin MA., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21954377

7. Histidine
Histidine plays an important role in promoting white and red blood cells, thus increasing the immune system in fight against forming of free radical and reducing the risk anemia., according to the study of "The role of histidine in the anemia of folate deficiency" by Cooperman JM, Lopez R., posted in PubMed(http://www.ncbi.nlm.nih.gov/pubmed/12486209), researchers concluded that concluded that folate deficiency causes histidine depletion through increased urinary excretion of this amino acid. Feeding histidine replenishes tissue levels ofhistidine, resulting in hemoglobin regeneration. Folic acid administration results in return of histidine to normal urinary levels. Thus, a combination of folic acidhistidine would be beneficial for folate deficient individuals.

8. Serine
As an amino acid, serine in soybean not only helps to maintain proper muscle build up by synthesizing fatty acids and proteins, it also is important for brain in to transport information between themselves and cells in other parts of the body, according to the study of "Transport systems of serine at the brain barriers and inbrain parenchymal cells" by Kasai Y, Tachikawa M, Hirose S, Akanuma S, Hosoya K., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21592122)

9. Alanine
Alanine not only is essential in production of energy in glucose synthesis (according to the study ofGlucose and insulin effects on the novo amino acidsynthesis in young men: studies with stable isotope labeled alanine, glycine, leucine, and lysine" by Robert JJ, Bier DM, Zhao XH, Matthews DE, Young VR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/6815417) it also enhances the immune system in production of anti bodies., according to the study of "Theimmune response of tetraparental mice to two synthetic amino acid polymers: "high-conjugation" 2,4 dinitrophenyl-glutamic acid57-lysine38-alanine5 (DNP-GLA5) and glutamic acid60 alanine30 tyrosine10 (GAT10)" by Warner CM, Fitzmaurice M,Maurer PH, Merryman CF, Schmerr MJ., posted in The Journey of Immunology (http://www.jimmunol.org/content/111/6/1887)

10. Isoleucine
Another animo acid helps to maintain the body tissues and store glycogen in muscles thereby reducing the risk of muscle breaking down during physical activity., according to the study of "Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes" by Doi M, Yamaoka I, Fukunaga T, Nakayama M., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/14651987), researchers that isoleucinestimulates the insulin-independent glucose uptake in skeletal muscle cells, which may contribute to the plasma glucose-lowering effect of isoleucine in normal rats.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/18522411
(2) http://www.ncbi.nlm.nih.gov/pubmed/18608549
(3) http://www.ncbi.nlm.nih.gov/pubmed?term=Effect%20of%20Germinated%20Soybean%20Protein%20Hydrolysates%20on%20Adipogenesis%20and%20Adipolysis%20in%203T3-L1%20Cells
(4) http://www.ncbi.nlm.nih.gov/pubmed/20302378
(5) http://www.ncbi.nlm.nih.gov/pubmed/22005499

Phytochemicals In Foods: The effects of Tocopherols

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Tocopherols

Tocopherols are phytochemincals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable and seed or nut oils, etc.

Health benefits
1. Antioxidative, anti-inflammatory, and anticarcinogenic activities
In the examination of the inhibition of inflammation as well as of cancer formation and growth in the lung and colon in animal models., using a tocopherol mixture that is rich in gamma-T (gamma-TmT, which contains 57%gamma-T), found that when given in the diet at 0.3%, gamma-TmT inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of human lung cancer cell H1299 xenograft tumors. gamma-TmT also decreased the levels of 8-hydroxydeoxyguanosine, gamma-H2AX, and nitrotyrosine in tumors. More evident anti-inflammatory and cancer preventive activities of dietary gamma-TmT were demonstrated in mice treated with azoxymethane and dextran sulfate sodium. These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols, according to "Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols" by Yang CS, Lu G, Ju J, Li GX.(1)

2. Cancer prevention
In the study of the cancer-preventive activities of tocopherols and tocotrienols, indicated that a gamma-tocopherol-rich mixture of tocopherols inhibits colon, prostate, mammary and lung tumorigenesis in animal models, suggesting that this mixture may have a high potential for applications in the prevention of human cancer. In this review, we discuss biochemical properties of tocopherols, results of possible cancer-preventive effects in humans and animal models and possible mechanisms involved in the inhibition of carcinogenesis. Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research, according to "Cancer-preventive activities of tocopherols and tocotrienols" by Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, Yang CS.(2)

3. Bone formation
In the investigation of the antioxidant and anti-inflammatory properties of Alpha- and gamma-tocopherol, the two predominant isomers of vitamin E and their effects on bone metabolism, found that gamma-tocopherol may uncouple bone turnover, resulting in more bone formation than resorption. Vitamin E supplements in the form of alpha-tocopherol suppress serum gamma-tocopherol levels and may have negative effects on bone formation. Further research is needed to investigate the potential anabolic effect of gamma-tocopherol from food sources on bone, according to "Effects of vitamin E on bone turnover markers among US postmenopausal women" by Hamidi MS, Corey PN, Cheung AM.(3)

4. Liver fibrosis
In the study of Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells, found that significant cell detachment was also observed in δ-tocopherol- and tocol-treated HSCs. Decreased protein expressions of α-smooth muscle actin and β1 integrin were observed in a dose-dependent manner. These results indicate that δ-tocopherol and tocol induce anoikis in activated HSCs, accordin g to "Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells" by Yamaguchi N, Mezaki Y, Miura M, Imai K, Morii M, Hebiguchi T, Yoshikawa K.(4)

5. Antioxidant and Antidiabetic Activities
In the determination of the antioxidant and antidiabetic activities of proximate composition, amino acids, fatty acids, tocopherols, sterols, glucosinolate and phenolic content in extracts, found that all examined extracts were prominently rich in phenolics and glucosinates, and they showed potent antidiabetic and antihemolytic activity. The present study could be helpful in developing medicinal preparations for the treatment of diabetes and related symptoms, according to "Compositional Studies: Antioxidant and Antidiabetic Activities of Capparis decidua (Forsk.) Edgew" by Zia-Ul-Haq M, Cavar S, Qayum M, Imran I, de Feo V.(5)

6. Breast cancer
in the investigation of the breast cancer effect of vitamin E, consisting od eight different variants: α-, β-, γ-, and δ-tocopherols (saturated phytyl tail) and α-, β-, γ-, and δ-tocotrienols (unsaturated phytyl tail), indicated that , γ-tocopherol, and more recently δ-tocopherol, have shown greater ability to reduce inflammation, cell proliferation, and tumor burden. Recent results have shown that γ-enriched mixedtocopherols inhibit the development of mammary hyperplasia and tumorigenesis in animal models, according to "Chemopreventive Activity of Vitamin E in Breast Cancer: A Focus on γ- and δ-Tocopherol" by Smolarek AK, Suh N.(6)

7. Colon cancer
In the investigation of the effects of both alpha and gamma tocopherol on the expression of PPARgamma mRNA and protein in SW 480 colon cancer cell lines and measurement of the intracellular concentrations of vitamin E in SW 480 colon cancer cell lines, found that both alpha and gamma tocopherol can upregulate the expression of PPARgamma which is considered an important molecular target for colon cancer chemoprevention, according to "Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines" by Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K.(7)

8. Antioxidant defense
in the study of salmon, a rich source of marine n-3 fatty acids, which may increase oxidative stress and, in turn, and its affect the antioxidant defense system in blood plasma and erythrocytes of pregnant women, found that besides, a concomitant increase in selenium and glutathione concentration as well as glutathione peroxidase and reductase activities were detected as pregnancy progressed. However, tocopherols, retinol, β-carotene, and coenzyme Q(10) decreased in late pregnancy. Collectively, our findings lead to the hypothesis that increased farmed salmon intake may increase antioxidant defenses during pregnancy, according to "Does Consumption of Two Portions of Salmon Per Week Enhance the Antioxidant Defense System in Pregnant Women?" by García-Rodríguez CE, D Mesa M, Olza J, Vlachava M, Kremmyda LS, Diaper ND, Noakes PS, Miles EA, Ramírez-Tortosa MC, Liaset B, Frøyland L, Rossary A, Farges MC, Vasson MP, Aguilera CM, Helmersson-Karlqvist J, Godfrey KM, Calder PC, Basu S, Gil A.(8)

9. The antioxidant and anti-inflammatory activities
In the investigation of the antioxidant and anti-inflammatory actions of tocopherolsin mice and determination of whether the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is involved in these activities, indicated that the antioxidant and anti-inflammatory activities of γ-TmT in the colon are mostly due to the direct action oftocopherols in trapping reactive oxygen and nitrogen species, independent of the antioxidant enzymes and anti-inflammatory proteins that are regulated by Nrf2; however, Nrf2 knockout appears to affect the serum levels of tocopherol metabolites, according to "The antioxidant and anti-inflammatory activities oftocopherols are independent of Nrf2 in mice" by Li G, Lee MJ, Liu AB, Yang Z, Lin Y, Shih WJ, Yang CS.(9)

10. Cognitive effects
In the examination of the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopherylquinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people, found that compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD, according to "Tocopherolsand tocotrienols plasma levels are associated with cognitive impairment" by Mangialasche F, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M, Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P; AddNeuroMed Consortium.(10)

11. Renal effects
In the examination of whether γ-tocotrienol (GT3) protects against mitochondrial dysfunction and renal proximal tubular cell (RPTC) injury caused by oxidants, showed that report demonstrating the protective effects of GT3 against RPTC injury by: 1) decreasing production of ROS, 2) improving mitochondrial respiration, coupling, ΔΨ(m), and F₀F₁-ATPase function, 3) maintaining ATP levels, and 4) preventing RPTC lysis. Our data suggest that GT3 is superior to AT in protecting RPTCs against oxidant injury and may prove therapeutically valuable for preventing renal injury associated with oxidative stress, according to "γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death" by Nowak G, Bakajsova D, Hayes C, Hauer-Jensen M, Compadre CM.(11)

12. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20716280
(2) http://www.ncbi.nlm.nih.gov/pubmed/19748925
(3) http://www.ncbi.nlm.nih.gov/pubmed/22308007
(4) http://www.ncbi.nlm.nih.gov/pubmed/22293208
(5) http://www.mdpi.com/1422-0067/12/12/8846/
(6) http://www.ncbi.nlm.nih.gov/pubmed/22254089
(7) http://www.ncbi.nlm.nih.gov/pubmed/14521714
(8) http://www.ncbi.nlm.nih.gov/pubmed/22229304
(9) http://www.ncbi.nlm.nih.gov/pubmed/22226829
(10) http://www.ncbi.nlm.nih.gov/pubmed/22192241
(11) http://www.ncbi.nlm.nih.gov/pubmed/22040679

Most common Diseases of 50plus: The Obesity' Research and Studies of Green tea extract thermogenesis-induced Weight loss

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Research and Studies of Green tea extract thermogenesis-induced Weight loss

Intake of tea catechins is associated with a lower risk of cardiovascular disease. The antioxidative activity of tea-derived catechins has been extensively studied, as well as it is associated with increased weight loss due to diet-induced thermogenesis, by inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine) as the result of stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis, according to the st5udy conducted by South China Institute of Botany, Chinese Academy of Sciences(1)

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

(1) Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase" by Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y., posted in PubMed

General Health: Candida Albicans: Treatment and Controlling of Candida Albicans Overgrowth - The Effectiveness of Minerals and Mineral Compounds

C. Minerals and mineral compounds

1. Coral Calcium
One of the richest sources of Calcium not only is an important mineral in building stronger, denser bones early in life and keeping bones strong(248) and healthy later in life and preventing the risk of osterporosis(249), but also helps to alkalize the body that eliminate the favor environment for candida overgrowth(250).

2. Magnesium Citrate
Magnesium Citrate is a magnesium salt of citric acid, a chemical agent used medicinally as a saline laxative(251). Besides it is important to maintain proper level of pH(252) for the body's organs to enhance their biochemical pathways for detoxification(253), that limits or reduces the over growth of candida, it also acts as a defecation in stimulating naturally bowel movement.
The mineral, magnesium plays a key role in the immune response, by acting as a co-factor for immunoglobulin synthesis(254) that significantly increases for both IgA and IgG, the antibody molecules that protect our body against bacterial and viral infections(255) and the lining of the respiratory passages, gastrointestinal andgenitourinary tract(255).

3. Lithium chloride
Lithium chloride is a chemical compound with the formula LiCl. The salt is a typical ionic compound. While maintaining the proper PH levels(257), lithium also suppresses the yeast phosphoglucomutase activity(256) and inhibits the candida albicans filamentation and hyphal outgrowth(258).

4. Sodium bicarbonate
Used as an alkaline treatment(259), sodium bicarbonate is important to balance the levels of PH by taking away the acidity environment for candida overgrowth(260)(261). Researchers found that 5% sodium bicarbonate on the adherence of Candida albicans to thermally activated acrylic resin proved to be a viable alternative in the reduction of Candida albicans(262).

5. Phosphonium salts
Phosphonium salts with long alkyl chains (C18) were found to show high levels of antimicrobial activity(263). In the alkyltrimethylphosphonium salts(263), the bactericidal activity against S. aureus and Escherichia coli increased with increasing alkyl chain length(263), probably through its antimicrobial polymers(264), according to the joint study by University of New Brunswick, Southwest Petroleum University, and North China Electric Power University

6. Zinc
Zinc besides is an important mineral in boosting immune system activity(265)(266). Its nano-structure zinc(II) coordination compounds, has been used in zinc therapy to treat candida overgrowth(267) by promoting metallothionein (MT)(found in high concentration in intestinal mucosa)synthesis(268) through its anti inflammatory activity(269).

7. Etc

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

+ References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicansisolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicansby Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistantCandida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(249) By the way, doctor. I recently saw a TV ad for a product called "coralcalcium," which is supposed to prevent osteoporosis and other diseases. What do you know about it by Robb-Nicholson C.(PubMed)
(250) The effect of probiotic bacteria on transepithelial calcium transport andcalcium uptake in human intestinal-like Caco-2 cells by Gilman J1, Cashman KD.(PubMed)
(251) Sodium Picosulfate with Magnesium Citrate (SPMC) Plus Laxative Is a Good Alternative to Conventional Large Volume Polyethylene Glycol in Bowel Preparation: A Multicenter Randomized Single-Blinded Trial by Kim HG1, Huh KC, Koo HS, Kim SE, Kim JO, Kim TI, Kim HS, Myung SJ, Park DI, Shin JE, Yang DH, Lee SH, Lee JS, Lee CK, Chang DK, Joo YE, Cha JM, Hong SP, Kim HJ.(PubMed)
(252) Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Ruml LA1, Pak CY.(PubMed)
(253) Efficacy of magnesium citrate cathartic in pediatric toxic ingestions by Sue YJ1, Woolf A, Shannon M.(PubMed)
(254) Study of possible correlation between BLOOD IMMUNOGLOBULIN G INCREASED and MAGNESIUM CITRATE(Meds fact)
(255)In vitro antiviral and antibacterial activity of commercial intravenousimmunoglobulin preparations--a potential role for adjuvant intravenousimmunoglobulin therapy in infectious diseases by Krause I1, Wu R, Sherer Y, Patanik M, Peter JB, Shoenfeld Y.(PubMed)
(256)In-silico identification and characterization of organic and inorganic chemical stress responding genes in yeast (Saccharomyces cerevisiae) by Barozai MY1, Bashir F2, Muzaffar S2, Afzal S2, Behlil F2, Khan M2.(PubMed)
(257) Four pathogenic Candida species differ in salt tolerance. Krauke Y1, Sychrova H.(PubMed)
(258) DISSOCIATION OF CANDIDA ALBICANS BY LITHIUM CHLORIDE AND IMMUNE SERUM by Mickle WA1, Jones CP.(PubMed)
(259) A sodium carbonate-bicarbonate buffer for alkaline phosphatases by DELORY GE, KING EJ (PubMed))260) The relationship between the acid and alkaline phosphatase activity and the adherence of clinical isolates of Candida parapsilosis to human buccal epithelial cells by Fernanado PH1, Panagoda GJ, Samaranayake LP.(PubMed)
(260) Candida albicans Rim13p, a protease required for Rim101p processing at acidic and alkaline pHs by Li M1, Martin SJ, Bruno VM, Mitchell AP, Davis DA.(PubMed)
(261) Adaptation to environmental pH in Candida albicans and its relation to pathogenesis. Davis D1.(PubMed)
(262) Effect of sodium bicarbonate on Candida albicans adherence to thermally activated acrylic resin by Sousa FA1, Paradella TC, Koga-Ito CY, Jorge AO.(PubMed)
(263) Synthesis and antimicrobial activity of dimethyl- and trimethyl-substituted phosphonium salts with alkyl chains of various lengths by A Kanazawa, T Ikeda, and T Endo(PubMed)
(264) Antimicrobial Polymeric Materials with Quaternary Ammonium and Phosphonium Salts by Xue Y1,2, Xiao H3, Zhang Y4.(PubMed)
(265) Zinc and the immune system by Rink L1, Gabriel P.(PubMed)
(266) The immune system and the impact of zinc during aging by Haase H1, Rink L.(PubMed)
(267) Some new nano-structure zinc(II) coordination compounds of an imidazolidine Schiff base: spectral, thermal, antimicrobial properties and DNA interaction. Montazerozohori M1, Musavi SA2, Naghiha A3, Zohour MM4.(PubMed)
(268) Candida article zinc and metallothionein(Cure zone)
(269) Metallothionein as an Anti-Inflammatory Mediator(Mediators of inflammation)

The Tasty Smoothie of Green Tea, Grape and Turmeric for Prevention and Treatment of Non-alcoholic Fatty Liver Disease(NAFLD)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Non-alcoholic Fatty Liver Disease(NAFLD)

Yield: 2 servings (about 8 ounces each)

1 1/2 cups grape

1 tsp curcumin

1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Non-alcoholic Fatty Liver Disease(NAFLD) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.

Recent studies back by well known institutions poposed, Bernerine, Resveratrol and Epigallocatechin-3-Gallate isolated from Turmeric, blueberry and green tea respectively may be the next generation of natural ingredients for prevention and treatment of Non-alcoholic Fatty Liver Disease.

Berberine(BBR) is a phytochemical found abundantly in root, bark, stem in plants of Berberis, including turmeric. According to the joint study lead by Fudan University, BBR ameliorates NAFLD and related metabolic disorders(2) through a direct regulation of hepatic lipid metabolism and modulation of hepatic mRNA and lncRNA expression in gene regulation(3).

Dr. Han L and professors in a Chinese study suggested, berberine promoted lipid metabolism and ameliorated lipid deposition in liver cells of non-alcoholic fatty liver disease (NAFLD) rats induced by high fat diet through LXRα/FAS signaling pathway in mediated hepatocyte fatty deposits(4).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in blueberry and grape. According to the joint study lead by Aarhus University Hospital and Department of Clinical Medicine, resveratrol expressed a mild effect in ameliorating on liver function and liver fat accumulation(5)through inhibited pro inflammatory and promoted apoptotic expression(6).

Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well herbs and herbal formulae such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet, were found not only to improve biochemical and histological change in nonalcoholic fatty liver disease, through inhibiting lipid accumulation and restore the impaired oxidation of long-chain fatty acids(1)

Green tea has been a precious drink in traditional Chienese culture and used exceptional in socialization for more than 4000 thousand years. According to the joint study lead by the Departamento de Fisiologia-Universidade Federal de São Paulo, Epigallocatechin-3-Gallate isolated from green tea extract prevent fatty liver through restored a normal hepatic metabolic profile and attenuated high-fat diet (HFD)-induced effects, in animal study(7) as well as improved insulin resistance(8)(9) and metabolic profiles in normolipidic diet(8).

Taking altogether, The combination of Green Tea, Grape and Turmeric may offer the potential effect not only in prevention of the onset and treatment of Non-alcoholic Fatty Liver Disease(NAFLD)s, through their anti lipid accumulation effect.
People who are at increased risk of Non-alcoholic Fatty Liver Disease(NAFLD) due to family history, obesity,..... are wise to drink at least one serving daily. People with Non-alcoholic Fatty Liver Disease(NAFLD), should drink the juice as much as they can, depending to the toleration of digestive system.
Change of life style and diet pattern are recommended.

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References

(1) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y1, Takamura T, Honda M, Kita Y, Zen Y, Kato K, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T,Mizukoshi E, Kaneko S.(PubMed)

(2) Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease by Yan HM1, Xia MF1, Wang Y2, Chang XX1, Yao XZ3, Rao SX3, Zeng MS3, Tu YF4, Feng R2, Jia WP4, Liu J5, Deng W6, Jiang JD2, Gao X1.(PubMed)

(3) Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles by Yuan X1, Wang J2, Tang X3, Li Y4, Xia P5, Gao X6.(PubMed)

(4) [Intervention of berberine on lipid deposition in liver cells of non-alcoholic fatty liver diseaserats induced by high fat diet].[Article in Chinese] by Han L, Yang QH, Zhang YP, Yan HZ, Zhu XF, Gong XW, Jin L, Wang PP, Liu YZ, Liang YJ.(PubMed)

(5) Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease by Heebøll S1,2, Kreuzfeldt M1, Hamilton-Dutoit S3, Kjær Poulsen M4, Stødkilde-Jørgensen H5, Møller HJ2, Jessen N6,7, Thorsen K7, Kristina Hellberg Y8, Bønløkke Pedersen S5, Grønbæk H1.(PubMed)

(6) Resveratrol modulates autophagy and NF-κB activity in a murine model for treating non-alcoholic fatty liver disease. by Li L1, Hai J1, Li Z1, Zhang Y1, Peng H1, Li K1, Weng X2.(PubMed)

(7) Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet by Santamarina AB1, Oliveira JL1, Silva FP1, Carnier J1, Mennitti LV2, Santana AA1, de Souza GH3, Ribeiro EB1, Oller do Nascimento CM1, Lira FS4, Oyama LM1.(PubMed)

(8) Decaffeinated green tea extract rich in epigallocatechin-3-gallate improves insulin resistance and metabolic profiles in normolipidic diet--but not high-fat diet-fed mice. by Santana A1, Santamarina A1, Souza G2, Mennitti L3, Okuda M1, Venancio D4, Seelaender M5, do Nascimento CO1, Ribeiro E1, Lira F6,Oyama L7.(PubMed)

(9) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1.(PubMed)

Herbal therapy: Popular Herbal Elecampane (Inula helenium)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Elecampane

Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nula, belonging to Asteraceae, native to Southern Europe, andAsia. It has been used in traditional and herbal medicine in treating in bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

Health Benefits
1. Antioxidant response
In the evaluation of fractionated the methanolic extract and theirs detoxifying enzymes effect found that the highest QR-inducing activity and also induced glutathione S-transferase in a dose-dependent manner. Its potential to induce the reporter activity suggested an antioxidant response element-mediated mechanism of action in the induction of phase II detoxifying enzymes, according to the study of "Induction of detoxifying enzyme by sesquiterpenes present in Inula helenium" by Lim SS, Kim JR, Lim HA, Jang CH, Kim YK, Konishi T, Kim EJ, Park JH, Kim JS.(1)

2. Antiproliferative effects
In the investigation of components ginger and elecampane of Padma Laxand theirs effect on constipation found that PL exhibits antiproliferative properties which may be beneficial to prevent constipation-related cancer, according to the study of "Antiproliferative properties of Padma Lax and its components ginger andelecampane" by Hofbauer S, Kainz V, Golser L, Klappacher M, Kiesslich T, Heidegger W, Krammer B, Hermann A, Weiger TM.(2)

3. Prophet Job diseases
In the observation of Elecampane (Inula Campana) and it ani Prophet Job disease found that the herb relieves all kinds of pains, especially those arising from chills, and animal bites. In traditional medicine, Elecampane was and is still used in different forms for the cure of many diseases according to "Elecampane and Job's disease" by Al-Gammal SY.(3)

4. Antimycobacterial effects
In the evaluation of the root extracts of Elecampane (Inula helenium L.; Asteraceae) and Sweet Coneflower (Rudbeckia subtomentosa Pursh.; Asteraceae and their effects in Antimycobacterial eudesmanolides found that l. helenium, which exhibited significant activity against Mycobacterium tuberculosis, provided the known eudesmanolides alantolactone, isoalantolactone, and 11 alpha H, 13-dihydroisoalantolactone, according to "Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa" by Cantrell CL, Abate L, Fronczek FR, Franzblau SG, Quijano L, Fischer NH.(4)

5. Relaxant effects
In the examination of the effects of volatile oils of 22 plants from 11 different families and of some of their constituents on tracheal and ileal smooth muscles found that in all of the oils had relaxant effects on the tracheal smooth muscle, the most potent were angelica root, clove, elecampane root, basil and balm leaves oil. 16 oils inhibited the phasic contractions of the ileal myenteric plexus-longitudinal muscle preparation, according to "Relaxant effects on tracheal and ileal smooth muscles of the guinea pig" by Reiter M, Brandt W.(5)

6. Anti-tumor activity
In the identification of botanical extracts with antineoplastic activity from Inulahelenium root and its effect found that the Inula helenium extract revealed a highly selective toxicity toward four different tumor cell lines (HT-29, MCF-7, Capan-2 and G1), but a much lower toxicity against healthy human peripheral blood lymphocytes (PBLs) from two donors, according to "Tumor cell specific toxicity of Inula helenium extracts" by Dorn DC, Alexenizer M, Hengstler JG, Dorn A.(6)

7. Cytostatic effect
In the affirmation of Biological activity of peptide extracts of medicinal plants, including Inula helenium L., found that thiers effect in non-small-cell lung carcinoma A549 cells, lung cancer H1299 cells, and cervical cancer HeLa cells, found that the cytostatic effect was produced by peptide extracts of Camelia sinesis Kuntze, Inonotus obliquus, and a mixture Inula helenium L., Chelidonium majus L., Equisetum arvense L., and Inonotus obliquus, according to "Cytostatic activity of peptide extracts of medicinal plants on transformed A549, H1299, and HeLa Cells" by Tepkeeva II, Aushev VN, Zborovskaya IB, Demushkin VP.(7)

8. Natural preservative system
In observation of development of a new natural preservative system containing both chitosan and I. helenium L. extract found that the patch test also showed that this preservative system reduced skin irritation by about 30-50%, as compared to the organic preservative system. Therefore, the good natural preservative system including chitosan and Inula helenium L. extract could be incorporated in cosmetic formulations according to "Development of a natural preservative system using the mixture of chitosan-Inula helenium L. extract" by Seo SB, Ryu CS, Ahn GW, Kim HB, Jo BK, Kim SH, Lee JD, Kajiuchi T.(8)

9. Skin cancer
in the study of Isocostunolide,a sesquiterpene lactone isolated from the roots ofInula helenium and its effect in cytotoxicity found that isolated and characterized isocostunolide from I. helenium. This compound induces apoptosis through a mitochondria-dependent pathway in A2058 cells, according to "Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells" by Chen CN, Huang HH, Wu CL, Lin CP, Hsu JT, Hsieh HP, Chuang SE, Lai GM.(9)

10. Anti stress
In the evaluation of preparations from the underground part of elfwort (Inulahelenium) and its antistressor and antioxidant properties found that The preparations produced a protective effect with respect to internal organs, blood, carbohydrate metabolism, and lipid peroxidation process, according to "[Mechanisms of antistressor activity of Inula helenium preparations].[Article in Russian]" by Nesterova IuV, Zelenskaia KL, Vetoshkina TV, Aksinenko SG, Gorbacheva AV, Gorbatykh NA.(10)

11. Etc.

Side effects
1. Elecampane may cause allergic effect, according to "Contact allergy and medicinal herbs.[Article in English, German]" by Aberer W.(a)
2. Do not use the herb if you are pregnant or breast feeding without approval of related field specialist
3. Do not use elecampane in children
4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/17887945
(2) http://www.ncbi.nlm.nih.gov/pubmed/16582559
(3) http://www.ncbi.nlm.nih.gov/pubmed/12587579
(4) http://www.ncbi.nlm.nih.gov/pubmed/10364842
(5) http://www.ncbi.nlm.nih.gov/pubmed/4039178
(6) http://www.ncbi.nlm.nih.gov/pubmed/16912983
(7) http://www.ncbi.nlm.nih.gov/pubmed/19526129
(8) http://www.ncbi.nlm.nih.gov/pubmed/18498511
(9) http://www.ncbi.nlm.nih.gov/pubmed/16697106
(10) http://www.ncbi.nlm.nih.gov/pubmed/14558358

(a) http://www.ncbi.nlm.nih.gov/pubmed/17919303

Traditional Chinese Medicine Herbal Therapy - Popular Herbal Chinese Herbs – Bai Jie Zi (Semen Sinapis Albae)

Ingredients
1. Sinalbin
2.Myrosin
3. Sinapine
4. 4-hydroxybenzoylcholine
5. 4-hydroxybenzylamine
6. Glucosinalbin
7. Sinapinrhodanide
8. Fatty acid
9. Polysaccharides
10. Etc.

Health Benefits
1. Liver cancer
Glucoraphasatin and myrosinase were isolated and purified from Daikon sprouts and Sinapis alba L, has demonstrated the activity as a potent inducer of hepatic enzymes involved in the detoxification of chemical carcinogens, according to the study of “4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent” by Abdull Razis AF, De Nicola GR, Pagnotta E, Iori R, Ioannides C.(1).

2. Antioxidants
Bai Jie Zi (Mustard Seed) has decreased plasma levels of the lipid peroxidation product malonaldehyde in mice exposed to the colon cancer-inducer azoxymethane (AOM) and reduced formation of colon adenomas by about 50%, according to the study of “Mustard seeds (Sinapis Alba Linn) attenuate azoxymethane-induced colon carcinogenesis” by Yuan H, Zhu M, Guo W, Jin L, Chen W, Brunk UT, Zhao M(2).

3. Asthma
Plasters made up of Gansui (Radix Euphorbiae Kansui), Baijiezi (Semen Sinapis Albae), Mahuang (Herba Ephedrae), Xixin (Herba Asari), etc. were applied to Feishu (BL 13), Fengmen (BL 12), Dingchuan (EX-B 1), Pishu (BL 20) Shenshu (BL 23), etc. has exerted the effectively improve asthma patients’ clinical symptoms, lower serum IgE and Eos count and raise LTR, according to the study of”[A study on the time-effect relationship in the treatment of bronchial asthma with medicinal vesiculation therapy]. [Article in Chinese]” by Zhuang LX, Zhao MH, Yang JJ, Deng QP.(3).

4. Calcium-rich drinks
A calcium-soluble protein isolate (CSPI) was prepared from the supernatant obtained after addition of 0.75 M calcium chloride to a pH 5.0 aqueous extract of yellow mustard (Sinapis alba) seed meal may be the next generation used to prepare calcium-fortified high protein liquid products, according to the study of “Characterization of a calcium-soluble protein fraction from yellow mustard (Sinapis alba) seed meal with potential application as an additive to calcium-rich drinks” by Aluko RE, Reaney M, McIntosh T, Ouellet F, Katepa-Mupondwa F.(4).

5. Prostatic hyperplasia
Sinalbin and beta-sitosterol separated from seeds of Brassica alba (Bai JIe Zi) significantly inhibit mice prostatic hyperplasia induced by testosterone propionate and activity of serum acid phosphatase, according to the study of “[An experimental study(II) on the inhibition of prostatic hyperplasia by extract of seeds of Brassica alba][Article in Chinese]” by Wu GX, Lin YX, Ou MR, Tan DF.(5).

6. Etc.

Side Effects
1. Allergic effects or occupational allergen as a result of the presence of predominant allergenic protein Sin a 1, according to the study of “Quantitative detection of allergenic protein Sin a 1 from yellow mustard (Sinapis alba L.) seeds using enzyme-linked immunosorbent assay” by Shim YY, Wanasundara JP(a)
2. External use in a prolonged period can cause inflammation
3. Do not use the herb, if you are pregnant or breast feeding without consulting with the related field specialist.
4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21960141
(2) http://www.ncbi.nlm.nih.gov/pubmed/21605497
(3) http://www.ncbi.nlm.nih.gov/pubmed/17580442
(4) http://www.ncbi.nlm.nih.gov/pubmed/15366859
(5) http://www.ncbi.nlm.nih.gov/pubmed/15139111 (a)http://www.ncbi.nlm.nih.gov/pubmed/18217709