The Tasty Smoothie of Green Tea, Grape and Turmeric for Prevention and Treatment of Non-alcoholic Fatty Liver Disease(NAFLD)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.

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The smoothie for prevention and treatment of  Non-alcoholic Fatty Liver Disease(NAFLD)

Yield: 2 servings (about 8 ounces each)

1 1/2 cups grape

1 tsp curcumin

1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Non-alcoholic Fatty Liver Disease(NAFLD)  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.

Recent studies back by well known institutions poposed, Bernerine, Resveratrol  and Epigallocatechin-3-Gallate isolated from Turmeric, blueberry and green tea respectively may be the next generation of natural ingredients for prevention and treatment of Non-alcoholic Fatty Liver Disease.

Berberine(BBR) is a phytochemical found abundantly in root, bark, stem in plants of Berberis, including turmeric. According to the joint study lead by Fudan University, BBR ameliorates NAFLD and related metabolic disorders(2)  through a direct regulation of hepatic lipid metabolism and modulation of hepatic mRNA and lncRNA expression in gene regulation(3).

Dr. Han L and professors in a Chinese study suggested, berberine promoted lipid metabolism and ameliorated lipid deposition in liver cells of non-alcoholic fatty liver disease (NAFLD) rats induced by high fat diet through LXRα/FAS signaling pathway in mediated hepatocyte fatty deposits(4).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in blueberry and grape. According to the joint study lead by Aarhus University Hospital and Department of Clinical Medicine, resveratrol expressed a mild effect in ameliorating on liver function and liver fat accumulation(5)through inhibited pro inflammatory and promoted apoptotic expression(6).

Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well herbs and herbal formulae such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet, were found not only to improve biochemical and histological change in nonalcoholic fatty liver disease, through inhibiting lipid accumulation and restore the impaired oxidation of long-chain fatty acids(1)

Green tea has been a precious drink in traditional Chienese culture and used exceptional in socialization for more than 4000 thousand years. According to the joint study lead by the Departamento de Fisiologia-Universidade Federal de São Paulo, Epigallocatechin-3-Gallate isolated from green tea extract prevent fatty liver through restored a normal hepatic metabolic profile and attenuated high-fat diet (HFD)-induced effects, in animal study(7) as well as improved insulin resistance(8)(9) and metabolic profiles in normolipidic diet(8).

Taking altogether, The combination of Green Tea, Grape and Turmeric may offer the potential effect not only in prevention of the onset and treatment of Non-alcoholic Fatty Liver Disease(NAFLD)s, through their anti lipid accumulation effect.
 People who are at increased risk of Non-alcoholic Fatty Liver Disease(NAFLD) due to family history, obesity,..... are wise to drink at least one serving daily. People with  Non-alcoholic Fatty Liver Disease(NAFLD), should drink the juice as much as they can, depending to the toleration of digestive system.
Change of life style and diet pattern are recommended.

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References

(1) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y1, Takamura T, Honda M, Kita Y, Zen Y, Kato K, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T,Mizukoshi E, Kaneko S.(PubMed)

(2) Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease by Yan HM1, Xia MF1, Wang Y2, Chang XX1, Yao XZ3, Rao SX3, Zeng MS3, Tu YF4, Feng R2, Jia WP4, Liu J5, Deng W6, Jiang JD2, Gao X1.(PubMed)

(3) Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles by Yuan X1, Wang J2, Tang X3, Li Y4, Xia P5, Gao X6.(PubMed)

(4) [Intervention of berberine on lipid deposition in liver cells of non-alcoholic fatty liver diseaserats induced by high fat diet].[Article in Chinese] by Han L, Yang QH, Zhang YP, Yan HZ, Zhu XF, Gong XW, Jin L, Wang PP, Liu YZ, Liang YJ.(PubMed)

(5) Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease by Heebøll S1,2, Kreuzfeldt M1, Hamilton-Dutoit S3, Kjær Poulsen M4, Stødkilde-Jørgensen H5, Møller HJ2, Jessen N6,7, Thorsen K7, Kristina Hellberg Y8, Bønløkke Pedersen S5, Grønbæk H1.(PubMed)

(6) Resveratrol modulates autophagy and NF-κB activity in a murine model for treating non-alcoholic fatty liver disease. by Li L1, Hai J1, Li Z1, Zhang Y1, Peng H1, Li K1, Weng X2.(PubMed)

(7) Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet by Santamarina AB1, Oliveira JL1, Silva FP1, Carnier J1, Mennitti LV2, Santana AA1, de Souza GH3, Ribeiro EB1, Oller do Nascimento CM1, Lira FS4, Oyama LM1.(PubMed)

(8) Decaffeinated green tea extract rich in epigallocatechin-3-gallate improves insulin resistance and metabolic profiles in normolipidic diet--but not high-fat diet-fed mice. by Santana A1, Santamarina A1, Souza G2, Mennitti L3, Okuda M1, Venancio D4, Seelaender M5, do Nascimento CO1, Ribeiro E1, Lira F6,Oyama L7.(PubMed)

(9) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1.(PubMed)