Medical Advisor Journals

Saturday, June 4, 2016

Most common Diseases of 50plus: The Obesity' Research and Studies of Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Research and Studies of Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet

In this 2-year trial, we randomly assigned 322 moderately obese subjects (mean age, 52 years; mean body-mass index [the weight in kilograms divided by the square of the height in meters], 31; male sex, 86%) to one of three diets: low-fat, restricted-calorie; Mediterranean, restricted-calorie; or low-carbohydrate, non-restricted-calorie, conducted by Ben-Gurion University of the Negev(1), scientists found that Mediterranean and low-carbohydrate diets may be effective alternatives to low-fat diets. The more favorable effects on lipids (with the low-carbohydrate diet) and on glycemic control (with the Mediterranean diet) suggest that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

(1) "Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet" by Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, Golan R, Fraser D, Bolotin A, Vardi H, Tangi-Rozental O, Zuk-Ramot R, Sarusi B, Brickner D, Schwartz Z, Sheiner E, Marko R, Katorza E, Thiery J, Fiedler GM, Blüher M, Stumvoll M, Stampfer MJ; Dietary Intervention Randomized Controlled Trial (DIRECT) Group., posted in PubMed

The Smoothie of Alfalfa Sprout and Fax seed for Ameliorated Breast Atrophy, the Menopausal Symptoms

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The finding of a natural source for reduced risk and treatment of Breast atrophy has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Breast atrophy is a normal health condition of shrinkage of the breasts in the stage of menopause due to low level of estrogen and higher level of androgen. Since breast atrophy is an symptom caused estrogen deficiency due to aging, smoothie used for reduced severity of menopausal symptom may be also effective for delay the breast atrophy as well.
You can view the smoothie of Broccoli, and Flax seed in Ameliorated Menopausal Symptoms at this link where broccoli can be replaced by Alfalfa sprout for better effect

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Most common Diseases Free and Longevity of 50 plus - Organic Soy Part C By Foods to prevent and treat cancers

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)

The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.

Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".

Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein

F. By Foods to prevent and treat cancers
1. Bladder cancer
Soy phytochemicals have been associated with the protective effect against bladder cancer as it contains genistein, and the isoflavone-rich soy phytochemical concentrate (SPC). Dr. Singh AV and the research team at the Beth Israel Deaconess Medical Center, showed that Mice treated with genistin and SPC had reduced final tumor weights by 56% (P < 0.05) and 52% (P < 0.05), respectively, associated with induction of tumor cell apoptosis and inhibition of tumor angiogenesis in vivo. In addition, SPC treatment, but not genistin treatment, significantly inhibited lung metastases by 95% (P < 0.01) associated with significant down-regulation of NF-kappaB expression in tumor tissues and reduction of circulating insulin-like growth factor-I levels, suggesting that SPC may contain other bioactive ingredients that have antimetastatic activity(1).

2. Cervical cancer
Epidemiological and preclinical evidence suggests that polyphenolicphytochemicals exemplified by epigallocatechin gallate from tea, curcumin from curry and soya isoflavones possess cancer chemopreventive properties. Dr. Thomasset SC and scientists at the University of Leicester, in the review of above showed that the available evidence for tea polyphenols tentatively supports their advancement into phase III clinical intervention trials aimed at the prevention of progression of prostate intraepithelial neoplasia, leukoplakia or premalignantcervical disease. In the case of curcumin and soya isoflavones more studies in premalignacies seem appropriate to optimise the nature and design of suitable phase III trials. The abundance of flavonoids and related polyphenols in the plant kingdom makes it possible that several hitherto uncharacterised agents with chemopreventive efficacy are still to be identified, which may constitute attractive alternatives to currently used chemopreventive drugs(2).

3. Breast cancer
In a study of " Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women" , by A Cassidy, S Bingham and KD Setchell (Source from Dunn Clinical Nutrition Centre, Cambridge, UK. ) posted in The Americal Journal Clinical Nutrition, researchers indicated that these effects are presumed to be due to nonsteroidal estrogens of the isoflavone class, which behave as partial estrogen agonists/antagonists. The responses to soy protein are potentially beneficial with respect to risk factors for breast cancer and may in part explain the low incidence of breast cancer and its correlation with a high soy intake in Japanese and Chinese women(4). Other suggested high dietary levels of soy isoflavones do not stimulate breast or uterine proliferation in postmenopausal monkeys and may contribute to an estrogen profile associated with reduced breast cancer risk(6). One study indicated that Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species(3)

4. Endomatrial Cancer
In the study to investigate the interactive effect of polymorphisms in the sex hormone-binding globulin (SHBG) gene with soy isoflavones, tea consumption, and dietary fiber on endometrial cancer risk in a population-based, case-control study of 1,199 endometrial cancer patients and 1,212 controls, found that the Asp(327)Asn (rs6259) polymorphism was associated with decreased risk ofendometrial cancer, particularly among postmenopausal women (OR = 0.79, 95% CI = 0.62-1.00). This single nucleotide polymorphism (SNP) modified associations of soy isoflavones and tea consumption but not fiber intake with endometrial cancer, with the inverse association of soy intake and tea consumption being more evident for those with the Asp/Asp genotype of the SHBG gene at Asp(327)Asn (rs6259), particularly premenopausal women (P(interaction) = 0.06 and 0.02, respectively, for soy isoflavones and tea intake)(4). Other researchers suggested that a reduced risk of endometrial cancer was associated with total isoflavone intake (highest vs lowest quintile, ≥7.82 vs <1.59 mg per 1000 kcal/d, RR = 0.66, 95% CI = 0.47 to 0.91), daidzein intake (highest vs lowest quintile, ≥3.54 vs <0.70 mg per 1000 kcal/d, RR = 0.64, 95% CI = 0.46 to 0.90), and genistein intake (highest vs lowest quintile, ≥3.40 vs <0.69 mg per 1000 kcal/d, RR = 0.66, 95% CI = 0.47 to 0.91). No statistically significant association with endometrial cancer risk was observed for increasing intake of legumes, soy, tofu, or glycitein. Truncated age-adjusted incidence rates of endometrial cancer for the highest vs lowest quintile of total isoflavone intake were 55 vs 107 per 100 000 women per year, respectively. The partial population attributable risk percent for total isoflavone intake lower than the highest quintile was 26.7% (95% CI = 5.3% to 45.8%)(4a).

5. Thyroid cancer
In the study to observe that an acidic methanolic extract of soybeans contains compounds that inhibit thyroid peroxidase-(TPO) catalyzed reactions essential tothyroid hormone synthesis, showed that In the presence of iodide ion, genistein and daidzein blocked TPO-catalyzed tyrosine iodination by acting as alternate substrates, yielding mono-, di-, and triiodoisoflavones. Genistein also inhibited thyroxine synthesis using iodinated casein or human goiter thyroglobulin as substrates for the coupling reaction(5).

6. Stomach Cancer/Gastric Cancer
Genistein is a phytochemical in the Isoflavones, belonging to the group of Flavonoids (polyphenols), found abundantly in food of the family of legumes, soy, etc. In the study to determinewhether the effect of genistein is mediated via suppression of cyclo-oxygenase (COX)-2 protein, and elucidated the mechanism of action of this effect in the human gastric cancer cell line BGC-823, showed that Genistein treatment inhibited cell proliferation and induced apoptosis in a dose- and time-dependent manner; Western blotting analysis indicated a significant dose-dependent decrease in COX-2 protein levels. Genistein treatment exerted a significant inhibitory effect on activation of the transcription factor nuclear factor κB (NF-κB). Additionally, the NF-κB inhibitor pyrrolidine dithiocarbamate caused a reduction in COX-2 protein levels and NF-κB activation, similar to the effect of genistein(6).

7. Melanoma skin cancer
Gallic acid (GA) is a phytochemical in the class of Phenolic acids, found abundantly in tea, mango, strawberries, soy, etc. In the study to examine the influence of GA on the protein levels and gene expression of MMP-2 and MMP-9 and in-vitro migration and invasiveness of human melanoma cells, showed that GA has antimetastatic potential by decreasing invasiveness of cancer cells. Moreover, this action of GA was involved in the Ras, p-ERK signaling pathways resulting in inhibition of MMP-2 in A375.S2 human melanoma cells. These data, therefore, provide evidence for the role of GA as a potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells(7).

8. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/16452247
(2) http://www.ncbi.nlm.nih.gov/pubmed/17131309
(3) http://www.ncbi.nlm.nih.gov/pubmed/21462322
(4) http://www.ncbi.nlm.nih.gov/pubmed/19005973
(4a) http://www.ncbi.nlm.nih.gov/pubmed/22158125
(5) http://www.ncbi.nlm.nih.gov/pubmed/9464451
(6) http://www.ncbi.nlm.nih.gov/pubmed/22289529
(7) http://www.ncbi.nlm.nih.gov/pubmed/21734530

Friday, June 3, 2016

Food therapy - Vegetables - Broccoli (Calabrese cultivar)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Broccoli
Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

Nutrients
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Omega 3 fatty acid
5. Protein
6. Beta-carotene
7. Lutein and
8. Zeaxanthin
9. Thiamine (Vitamin B1)
10. Riboflavin (Vitamin B2)
11. Niacin (Vitamin B3)
12. Pantothenic acid (B5)
13. Vitamin B6
14. Folate (Vit. B9)
15. Vitamin C
16. Calcium
17. Tryptophan
18. Iron
19. Magnesium
20. Phosphorus
21.Potassium
22. Zinc
23. Etc.

Health Benefits
A. Health benefits according to studies
1. Potential health benefits
In the investigation of cruciferous vegetables which include broccoli, cabbage and cauliflower and theirs bioactive components in functional foods effect for the improvement of health found that the molecular basis of the biological activities of the chemicals present in broccoli potentially responsible for health promotion, from chemoprevention to cardio protection, are outlined based on in vitro and in vivo studies with a note on the structure activity relationship of sulforaphane and a few other isothiocyanates, according to "Potential health benefits of broccoli- a chemico-biological overview" by Vasanthi HR, Mukherjee S, Das DK.(a)

2. Chemical carcinogens
In the classification of edible plants belonging to the family Cruciferae and genusBrassica (e.g., broccoli and cauliflower) and its isothiocyanates (mostly in the form of their glucosinolate precursors) effect found that sprouts of many broccolicultivars contain negligible quantities of indole glucosinolates, which predominate in the mature vegetable and may give rise to degradation products (e.g., indole-3-carbinol) that can enhance tumorigenesis. Hence, small quantities of crucifer sprouts may protect against the risk of cancer as effectively as much larger quantities of mature vegetables of the same variety, according to "Broccolisprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens" by Fahey JW, Zhang Y, Talalay P.(b)

3. Anti cancers
In the evaluation of consumption of cruciferous vegetables (compared with total fruit and vegetable consumption) and its effect in reducing cancer risk at several organ sites found that these experiments provide very strong evidence for a major role of phase 2 enzymes in controlling the risk of exposure to carcinogens. An increasing number of phase 2 proteins that exert a variety of protective mechanisms are being identified. Thus, in addition to detoxifying electrophiles, these proteins exercise versatile, long-lasting and catalytic antioxidant protection, according to "Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism" by Talalay P, Fahey JW.(c)

4. Prostate cancer cells
In the research of Broccoli and its effect against prostate cancer found that Selenium-enriched broccoli sprouts were superior to normal broccoli sprouts in inhibiting cell proliferation, decreasing prostate-specific antigen secretion, and inducing apoptosis of prostate cancer cells. Furthermore, selenium-enrichedbroccoli sprouts but, not normal broccoli sprouts, induced a downregulation of the survival Akt/mTOR pathway, according to "Selenium enrichment of broccolisprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells" by Abdulah R, Faried A, Kobayashi K, Yamazaki C, Suradji EW, Ito K, Suzuki K, Murakami M, Kuwano H, Koyama H.(d)

5. Etc.

B. Health benefits according to concentration
1. Vitamin C
In the evaluation of pulmonary dysfunction. and it effects on pulmonary dysfunction found that At present, evidence from randomised-controlled trials is insufficient to recommend a specific role for vitamin C in the treatment of asthma. Further methodologically strong and large-scale randomised controlled trials are needed in order to address the question of the effectiveness of vitamin C in children with asthma but some outcome data showed effectiveness on lung function, symptom scores, IgE levels and inhaled steroid use. One small study showed a significant difference in % drop in FEV1 post-exercise, according to the study of "Vitamin C supplementation for asthma" by Kaur B, Rowe BH, Arnold E.(I)

2. Vitamin K
a. Degenerative diseases of ageing
Long-term vitamin K inadequacy may reduce the function of supporting the carboxylation of at least some of these Gla-protein that can lead the development of degenerative diseases of ageing including osteoporosis and atherosclerosis, according to the study of "Vitamin K, osteoporosis and degenerative diseases of ageing" by Cees Vermeer and Elke Theuwissen(II)

b. Intracranial bleeding
In a study in the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB, resulting in an overall incidence of 2.1/100,000 live births (95% confidence interval 1.2-3.5) conducted by University Medical Center Utrecht(III) indicated that Intracranial bleeding may be associated with vitamin K deficiency.

3. Folate
Folate beside is important for the production of red blood cells, and for the proper development of the brain, it also helps to enhance the replication and maintain DNA and RNA, thus reducing the risk of birth defects, in a study of "Go folic!" by Bland J., posted in PubMed, researchers state that in order to prevent neural tube defects (NTDs), and proactively prevent new cases of spina bifida and hydrocephalus, it is essential that women take folic acid well before becoming pregnant. Through the use of social networks, and the voice of healthcare professionals, it is hoped that more women than ever before will receive the Go Folic! message and start taking the 400mcg/day required to ensure the development of a healthy brain and spine.

4. Vitamin A
Vitamin A is not only important in preventing types I diabetes, according to "A close relationship between type 1 diabetes and vitamin A-deficiency and matrix metalloproteinase and hyaluronidase activities in skin tissues" byTakahashi N, Takasu S.(1) but also may be associated with compromised bone health, according to "Vitamins and bone health: beyond calcium and vitamin D" by Ahmadieh H, Arabi A.(IV)

5. Manganese
Manganese beside plays an vital role for the proper and normal growth of human bone structure (accodring to the study of "Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants" by Pabbruwe MB,Standard OC, Sorrell CC, Howlett CR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/15109850)), it also helps to reduce the risk of cancer, (according to the study of "The effects of 3, 4 or 5 amino salicylic acids onmanganese-induced neuronal death: ER stress and mitochondrial complexes" by Yoon H, Lee GH, Kim DS, Kim KW, Kim HR, Chae HJ., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21477646 researchers indicated that the salicylate analogues and the antioxidants did not mediate ER stress in this model. The salicylate analogues reduced reactive oxygen species (ROS) and reversed the deficient mitochondrial membrane potential that was induced by Mn. Taken together, the 3, 4, 5 ASA worked in a similar way, regulating the Mn-induced mitochondrial dysfunction and protecting cells.

6. Etc.

C. Other health benefits
1. Breast Cancer
Broccoli contains high amount of Sulforaphane which protects against all types of cancer due to its similar structure (phytonutrients) like other cruciferous vegetables, including breast cancer, according to "Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells" by Li Y, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D.(1)

2. Free radicals
Broccoli helps to fight against the forming of free radical by detoxificating and cleansing the toxins accumulated in the body, according to "Effect of broccoli(Brassica oleracea) and its phytochemical sulforaphane in balanced diets on the detoxification enzymes levels of tilapia (Oreochromis niloticus) exposed to a carcinogenic and mutagenic pollutant" by Villa-Cruz V, Davila J, Viana MT, Vazquez-Duhalt R.(2)

3. Diabetes
Since it contains high amount of fiber, it helps to improve the digestive system in carbohydrate metabolism by releasing the sugar slowly into blood stream that reduces the pancrease stress cause of insulin sensitive, according to 'Broccolisprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial" by Bahadoran Z, Mirmiran P, Hosseinpanah F, Hedayati M, Hosseinpour-Niazi S, Azizi F.(3)

4. Coagulation
Since it contains high amount of vitamin K, it helps to protect the underlayer of skin and prevent the skin damage caused by ultra violet sun light. Vitamin K also has a coagulative effect, according to "Vitamin K-dependent coagulation factors deficiency" by Brenner B, Kuperman AA, Watzka M, Oldenburg J.(4)

5. Etc.

Side effects
1. People who has over production of IgM immunoglobulins which makes blood thicken should talk to their doctor before taking high amount of broccoli.
2. Allergic reaction??
3. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/19519500
(b) http://www.ncbi.nlm.nih.gov/pubmed/9294217
(c) http://www.ncbi.nlm.nih.gov/pubmed/11694642

(I) http://www.ncbi.nlm.nih.gov/pubmed/19160185
(II) http://mi.rsmjournals.com/content/17/1/19.abstract
(III) http://www.ncbi.nlm.nih.gov/pubmed/21967159
(IV) http://www.ncbi.nlm.nih.gov/pubmed/19160185

(1) http://www.ncbi.nlm.nih.gov/pubmed/20388854
(2) http://www.ncbi.nlm.nih.gov/pubmed/19144376
(3) http://www.ncbi.nlm.nih.gov/pubmed/21559038
(4) http://www.ncbi.nlm.nih.gov/pubmed/19598072

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Risk factors

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

The Risk factors

1. Family history
Risk of PCOs is increase if your mother or sister has PCOS(29). According to North Staffordshire Hospital, polycystic ovaries are highly prevalent within families as an autosomal dominant trait, in the analysis of 29 polycystic ovary syndrome and 10 control families(30).

2. Reproductive age women
Polycystic ovary syndrome (PCOS) affects 4% to 18% of reproductive-aged women(31)

3. Environment risks
a. Eating plastic-packaged food(32), fruit with pericarp(32) and drinking alcohol(32) were associated to the independent risk factors for PCOS. According to the Second Affiliated Hospital of Nanjing Medical University, risks of PCOs increased with the use of disposable plastic cup for drinking, cooking oil fume and indoor decoration(33).
b. Exposure to industrial products such as Bisphenol A (BPA)(36)were found to exacerbate the clinical course of PCOS(34) as they exhibited impairment of normal reproductive function and metabolic regulation(35).

4. Dietary factor
Over-nutrition with foods in advanced glycated end products (AGEs) is found to associated to risk of PCOs(34).

5. Metabolic perturbations begin early in adolescence are also found to elevate risk of PCOs(37).

6. Psychotropic medication
Prolonged period uses of psychotropic drugs such as mood stabilizers, lithium are also induced higher risk of PCOs(38). Women with epilepsy are also at risk of developed polycystic ovary syndrome (PCOS) if treated by valproate sodium (VPA) therapy(39)(40).

7. Genetic mutations
Although it is uncleared, genetic mutation of certain genes may be associated to the risk of PCOs, according to studies, such as the zona pellucida 4 (ZP4)(41) gene, polymorphism of FXIIIVal34Leu gene(42), C/T single nucleotide polymorphism at exon 17(43), single nucleotide polymorphism-56 of calpain-10 gene(44), vaspin rs2236242 polymorphism(45), etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(29) Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS) by Lenarcik A1, Bidzińska-Speichert B, Tworowska-Bardzińska U, Krępuła K.(PubMed)
(30) Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families by Govind A1, Obhrai MS, Clayton RN.(PubMed)
(31) Lifestyle changes in women with polycystic ovary syndrome. Moran LJ1, Hutchison SK, Norman RJ, Teede HJ.(PubMed)
(32) Environmental risk factors for women with polycystic ovary syndrome in china: a population-based case-control study by Zhang J1, Liu XF1, Liu Y1, Xu LZ1, Zhou LL1, Tang LL1, Zhuang J1, Li TT1, Guo WQ2, Hu R3, Qiu DS3, Han DW3.(PubMed)
(33) [Analysis of environmental factors and polycystic ovary syndrome]. [Article in Chinese] by Huang WJ1, Liu JY, Li LN.(PubMed)
(34) Phenotypes and enviromental factors: their influence in PCOS by Diamanti-Kandarakis E1, Christakou C, Marinakis E.(PubMed)
(35) Industrial endocrine disruptors and polycystic ovary syndrome by Palioura E1, Diamanti-Kandarakis E.(PubMed)
(36) Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic ovary syndrome (PCOS) by Rutkowska A1, Rachoń D.(PubMed)
(37) PCOS in adolescence and type 2 diabetes by Carreau AM1, Baillargeon JP.(PubMed)
(38) [Adverse events of psychotropic drugs]. [Article in Japanese] by Watanabe K, Kikuchi T.(PubMed)
(39) [Characteristics of women with epilepsy who developed polycystic ovary syndrome owing to the therapy with valproate sodium]. [Article in Japanese] Minagawa K1, Watanabe T, Oyanagi R.(PubMed)
(40) A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy by Hu X1, Wang J, Dong W, Fang Q, Hu L, Liu C.(PubMed)
(41) Study on the zona pellucida 4 (ZP4) gene sequence and its expression in the ovaries of patients with polycystic ovary syndrome by Meczekalski B1, Nawrot R, Nowak W, Czyzyk A, Kedzia H, Gozdzicka-Jozefiak A.(PubMed)
(42) Association study of polymorphism of FXIIIVal34Leu gene and polycystic ovary syndrome by Wang X1, Yang Y1, Huang Y2, Wang Q3.(PubMed)
(43) [Correlation between single nucleotide polymorphism of insulin receptor gene with polycystic ovary syndrome]. [Article in Chinese] by Chen ZJ1, Shi YH, Zhao YR, Li Y, Tang R, Zhao LX, Chang ZH.(PubMed)
(44) [Relationship between single nucleotide polymorphism-56 of calpain-10 gene and glucose and lipid metabolism in polycystic ovary syndrome patients]. [Article in Chinese] by Diao XH1, Shi YH, Gao Q, Wang LC, Tang R, Chen ZJ.(PubMed)
(45) Association between vaspin rs2236242 gene polymorphism and polycystic ovary syndrome risk by Kohan L1, Zarei A2, Fallahi S3, Tabiee O4.(PubMed)

Most common Diseases of 50plus: Heart Disease(The Articles) - Heart Diseases Affecting the Electrical System

Heart Disease

Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease. There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Heart Diseases Affecting the Electrical System

The electrical system within the heart is responsible for ensuring that the heart beats correctly so that blood can be transported throughout our the body. Any malfunction of the electrical system in the heart malfunction can cause a fast, slow, or irregular heartbeat.

Types of heart disease that affect the electrical system are known as arrhythmias. They can cause the heart to beat too fast, too slow, or irregularly. These types of heart disease include:

1. Sinus tachycardia Sinus tachycardia occurs when the sinus rhythm is faster than 100 beats per minute therefore it increases myocardial oxygen demand and reduces coronary blood flow, thus precipitating an ischemia heart or valvular disease.

2. Sinus bradycardia
Sinus bradycardia occurs when a decrease of cardiac output results in regular but unusually slow heart beat less than 60 beats per minute. Symptoms of sinus bradycardia includes a feeling of weightlessness of the head, dizziness, low blood pressure, vertigo, and syncope.

3. Atrial fibrillation
Atrial fibrillation is an irregular heart rhythm that starts in the upper parts (atria) of the heart causing irregular beating between the atria and the lower parts (ventricles) of the heart. The lower parts may beat fast and without a regular rhythm. Symptoms of atrial fibrillation include dizziness, light-headedness, shortness of breath, chest pain and irregular heart beat.

4. Atrial flutter
Atrial flutter is an abnormal heart rhythm that occurs in the atria of the heart causing abnormalities and diseases of the heart. Symptoms of atrial flutter includes shortness of breath, chest pains, anxiety and palpitation.

5. Supraventricular tachycardia
Supraventricular tachycardia is described as rapid heart rate originating above the ventricles, or lower chambers of the heart causing a rapid pulse of 140-250 beats per minute. Symptoms of supraventricular tachycardia include palpitations, light-headedness, and chest pains.

6. Paroxysmal supraventricular tachycardia
Paroxysmal supraventricular tachycardia is described as an occasional rapid heart rate. Symptoms can come on suddenly and may go away without treatment. They can last a few minutes or 1-2 days.

7. Ventricular tachycardia
Ventricular tachycardia is described as a fast heart rhythm that originates in one of the ventricles of the heart . This is a potentially life-threatening arrhythmia because it may lead to ventricular fibrillation and/or sudden death. Symptoms of ventricular tachycardia include light headedness, dizziness, fainting, shortness of breath and chest pains.

8.Ventricular fibrillation
Ventricular fibrillation is a condition in which the heart's electrical activity becomes disordered causing the heart's lower chambers to contract in a rapid, unsynchronized way resulting in little heart pumps or no blood at all, resulting in death if left untreated after in 5 minutes.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Most common Diseases of 50plus: The Obesity' Article of Herbal Bayberry Juice and Non acoholic fatty liver disease(NALFD)

The Obesity' Article of Herbal Bayberry Juice and Non acoholic fatty liver disease(NALFD)

Bay berry is a species of Myrica gale, genus Myrica, belonging to the family Myricaceae. Beside many nutrients, it also consists chemical constituents of Gallic acid, quercetin hexoside, quercetin deoxyhexoside, quercetin, anthocyanins, flavonols, and elllagitannins, etc.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.

The benefits
Bayberry juice is one of favorite drink among Chinese citizens. the fruits has been cultivated over 2000 years in Chinese literature for foods and medical use. Because of it recently found to contain certain chemicals with antioxidant effects, the fruits and its juice are being promoted as healthy products for commercial profits. In folk medicine, the fruit has been used in treating jaundice, painful and colitis, diarrhea, and nausea, etc.. Its main ingredient, anthocyanins, has been found to be effective in some studies for treating cardiovascular diseases and cancers. In a randomized, placebo-controlled, double-blind, crossover study of 44 participants (ages 18-25 y) given 250 mL of either bayberry juice or placebo twice daily for 4 wk, Bay berry juice is found to decrease inflammation and infection, liver cell apoptosis, and death of liver tissues as well as reduction of the risk of steatosis progreeion to cause NALFD. Of that results, researchers suggested that consumption of bayberry juice for a period of 4 wk can protect against NAFLD and its juice may be a candidate for potential prevention and treatment of Non acoholic fatty liver disease(NALFD).

The Side effects
1. Tannins found in bayberry may induce a drying effect on the skin and allergic effect in some patients
2. Bayberry may interactive with some prescription and non prescription medicine.
3. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Chemical composition of clarified bayberry (Myrica rubra Sieb. et Zucc.) juice sediment by Fang Z, Zhang M, Tao G, Sun Y, Sun J.(PubMed)(2) One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans.

Alvarez-Suarez JM1, Giampieri F2, Tulipani S3, Casoli T4, Di Stefano G5, González-Paramás AM6, Santos-Buelga C6, Busco F7, Quiles JL8, Cordero MD9, Bompadre S10, Mezzetti B11, Battino M12.(PubMed)
(3) Anthocyanins and their role in cancer prevention by Wang LS, Stoner GD.(PubMed)
(4) Effects of bayberry juice on inflammatory and apoptotic markers in young adults with features of non-alcoholic fatty liver disease by Guo H1, Zhong R2, Liu Y2, Jiang X3, Tang X3, Li Z3, Xia M4, Ling W3.(PubMed)
(5) Anaphylaxis and generalized urticaria from eating Chinese bayberry fruit by Wang HY, Gao ZS, Yang ZW, Shao JX, Zhao XZ, Dai Y, Van Ree R.(PubMed)