Medical Advisor Journals

Sunday, June 12, 2016

Phytochemicals in Foods - The Effects of Perillyl alcohol

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Perillyl alcohol

Perillyl alcohol is a phytochemicals in the class of Monoterpenes, found abundantly in citrus oils, caraway, mints, etc.

Health Benefits
1. Breast cancer
In the searching the effective way in treating breast cancer by investigating the activity of a combination of perillyl alcohol (POH), methyl jasmonate (MJ) with cisplatin, found that Combination treatment of POH and MJ blocked cells at the G0/G1 phase of the cell cycle and the addition of cisplatin forced the cells to progress through the cell cycle and induced apoptosis. Apoptotic mechanistic studies indicated that POH and MJ treatment activated tumor necrosis factor receptor 1 and this was further increased by the addition of cisplatin. It was also found that mitochondrial membrane potential decreased with POH and MJ treatment; this effect was further enhanced by cisplatin treatment, according to "Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin" byYeruva L, Hall C, Elegbede JA, Carper SW.(1)

2. Pancreatic cancer
In the development of enhanced single or combinatorial therapies to decrease the pathogenesis of this invariably fatal disease. Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a potent cancer gene therapeutic because of its broad-spectrum cancer-specific apoptosis-inducing properties as well as its multipronged indirect antitumor activities,
found that a dietary agent perillyl alcohol (POH) in combination with Ad.mda-7 efficiently reverses the mda-7/IL-24 "protein translational block" by inducing reactive oxygen species, thereby resulting in mda-7/IL-24 protein production, growth suppression, and apoptosis. Pharmacologic inhibitor and small interfering RNA studies identify xanthine oxidase as a major source of superoxide radical production causing these toxic effects, according to " Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol" by Lebedeva IV, Su ZZ, Vozhilla N, Chatman L, Sarkar D, Dent P, Athar M, Fisher PB.(2)

3. Skin cancer
in the evaluation of preparation and characterization ofa novel poly-lactic glycolic acid (PLGA)-based microparticle formulation of perillyl alcohol (POH) and its efficacy against di-methyl benzo anthracene-induced skin papilloma in Swiss albino mice, found that in vitro efficacy of POH-bearing PLGA microparticles was evaluated by examining their differential cytotoxicity and assessing their ability to inhibit epidermoid carcinoma cell line (A253). The POH-based microparticles when administered to tumor-bearing animals caused greater tumor regression and increased survival rate (∼80%) as compared with the group receiving free form of POH (survival rate 40%), according to "Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles" by Farazuddin M, Sharma B, Khan AA, Joshi B, Owais M.(3)

4. Lipid Membranes
In the assessment of the possible biophysical effects of these compounds on membranes quantitatively, the influence of limonene and its bio-oxidation products on a membrane model composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) using differential scanning calorimetry (DSC), isothermal titration calorimetry (ITC), and electron paramagnetic resonance spectroscopy (EPR), found that limonene (1), perillyl alcohol (2), and perillaldehyde (3) partitioned into the DMPC membrane, whereas perillic acid (4) did not. The DSC results demonstrated that all the partitioning compounds strongly perturbed the phase transition of DMPC, whereas no perturbation of the local membrane order was detected by EPR spectroscopy, according to "Influence of the Active Compounds of Perilla frutescens Leaves on Lipid Membranes" by Duelund L, Amiot A, Fillon A, Mouritsen OG.(4)

5. Antioxidant and antiproliferative effects
In the investigation of antioxidant potential of three monoterpenoids (carvone,perillyl alcohol, and α-terpineol), using two methods: DPPH and ORAC and the antiproliferative effect of these monoterpenoids against nine cancerous cell lines performed and compared to limonene and doxorubicin, found that all samples tested had very low antioxidant activity in the DPPH assay, but α-terpineol (2.72μmolTrolox equiv./μmol) could be compared to commercial antioxidants in the ORAC assay. The antiproliferative results obtained encourage future in vivo studies for α-terpineol, since this monoterpenoid presented cytostatic effect against six cell lines, especially for breast adenocarcinoma and chronic myeloid leukemia, in a range of 181-588μM, according to "Evaluation of the antioxidant and antiproliferative potential of bioflavors" by Bicas JL, Neri-Numa IA, Ruiz AL, De Carvalho JE, Pastore GM.(5)

6. Transplant coronary artery disease TCAD prevention
In the study of whether systematical dissection of the prenylation pathway to better define the mechanism behind statin inhibition in chronic allograft rejection in heart transplants, or transplant coronary artery disease (TCAD), found that FPT and GGPT-2 (inhibition) are the key enzymes in the HGM-CoA reductase pathway and most influential in TCAD prevention. TCAD reduction is most closely related to smooth muscle cell migration, but not its anti-inflammatory properties, according to "Prevention of transplant coronary artery disease by prenylation inhibitors" by Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP.(6)

7. Oxidative stress
In the investigation of the protective effects of perillyl alcohol (POH) on ethanol-induced acute liver injury in Wistar rats and its probable mechanism, ethanol administration decreased hepatic reduced glutathione content and various antioxidant enzymes activity. TNF-α production and NFκ-B activation was also found to be increased after ethanol administration. POH pre-treatment significantly ameliorates ethanol induced acute liver injury possibly by inhibition of lipid peroxidation, replenishment of endogenous enzymatic and non-enzymatic defense system, downregulation of TNF-α as well as NFκ-B, according to "Perillyl alcoholprotects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production" by Khan AQ, Nafees S, Sultana S.(7)

8. Non small cell lung cancer
In the investigation of the effects of perillyl alcohol (POH) and its metabolite perillic acid (PA) on the proliferation of non small cell lung cancer (NSCLC, A549, and H520) cells, found that exposing the cells to an IC50 concentration of POH or PA sensitized the cells to cisplatin and radiation in a dose-dependent manner. These results indicate that POH and PA in combination therapy may have chemotherapeutic value against NSCLC, according to "Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells" by Yeruva L, Pierre KJ, Elegbede A, Wang RC, Carper SW.(8)

9. Etc.

Most Common Diseases of 50Plus:The Research and Studies of Ischemic heart disease - The Do`s and Do not`s list

Cardiovascular disease is defined as medical conditions affecting the cardiovascular system, including heart, blood vessels(arteries and veins).

Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease.
There are many causes of heart diseases. Most of heart diseases are caused by high blood pressure contributes to hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat. All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Ischemic heart disease

Ischemic heart disease is defined as a condition of reduced blood supply of the heart muscle, as a result of coronary artery disease caused by plague building up in the arteries.

The Do`s and Do not`s list

1. Healthy diet
In the study to compare two strategies for atherosclerosis treatment: drugs and healthy lifestyle, found that Statins act mainly as lipid-lowering drugs but pleiotropic actions are also present. Healthy lifestyle, on the other hand, is effective and inexpensive and has no harmful effects. Five items are associated with lower cardiac risk: non-smoking, BMI ≤25, regular exercise (30 min/day), healthy diet (fruits, vegetables, low-saturated fat, and 5-30 g alcohol/day)(31).
a. Low intake of saturated and trans fats
Saturated and trans fats raise your low-density lipoprotein (LDL), or “bad,” cholesterol level, as it can cause clot up and hardening arterial wall, thus increasing the risk of cardiovascular risk and mortality(27).
d. Increase intake fish and olive oil
Studies indicate that the use of fish oil is associated with coronary heart diseaserisk reduction. A number of mechanisms may be responsible for such effects. These include prevention of arrhythmias as well as lowering heart rate and blood pressure, decreasing platelet aggregation, and lowering triglyceride levels. The latter is accomplished by decreasing the production of hepatic triglycerides and increasing the clearance of plasma triglycerides(28). Other researchers indicated that in both sexes consumption of olive oil and vegetable oil was inversely associated with serum cholesterol and glucose levels and systolic blood pressure(29).
c. High amount intake of in fiber
Consumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease. In a study of over 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91058 men and 245186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measurement error-corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronaryevents and a 27% (RR, 0.73; 95% CI, 0.61-0.87) decrease in risk of coronarydeath. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% CI, 0.77-1.07), 0.84 (95% CI, 0.70-0.99), and 1.00 (95% CI, 0.88-1.13), respectively, for all coronary events and 0.75 (95% CI, 0.63-0.
Fiber is found in whole grains, fruits, and vegetables. A fiber-rich diet not only helps lower your LDL cholesterol level, but also provides nutrients that may help protect against CHD(30).
d. Low intake of salt and sugar
d.1. Manage your blood pressure and reduce intake of salt, beverage and sugar
The worldwide increase in the incidence of metabolic syndrome correlates with marked increase in total fructose intake in the form of high-fructose corn syrup, beverage and table sugar. Increased dietary fructose intake in rodents has been shown to recapitulate many aspects of metabolic syndrome by causinghypertension, insulin resistance and hyperlipidaemia(32).
d.2. Prevent weight gain and control diabetes and prediabetes
In the study to test a 16-week group-based weight reduction intervention combining exercise, diet and behaviour change strategies aimed to increase self-efficacy (Healthy Eating and Exercise Lifestyle Program-HEELP) on weight, body mass index (BMI), waist circumference and exercise, found that The HEELP resulted inweight loss and improved exercise behaviour in obese people with CHD and T2DM(33).
d.3. Mediterranean style low-carb diet
The best approach to the dietary prevention of CVD is a Mediterranean style low-carb diet represented in the LOGI pyramid. Dietary guidelines for the prevention of CVD should to be revised accordingly(34).

2. Moderate exercise
Intensive exercise is not healthy for any age as it lowers the immune function prone for disease invasion, especially to elder. Moderate exercise enhances the blood flow and immune function, thus protecting again diseases and reducing the risk of progression of chronic diseases. Although most health organizations agree that 150 min . wk(-1) of physical activity will reduce the risk of all-cause and cardiovascular mortality, few randomized, controlled studies have examined whether completing more physical activity than the recommended amount will yield additional benefits. Findings from the present study suggest that there is a dose-response relationship between exercise duration and numerous health outcomes in postmenopausal women, including cardiorespiratory fitness, body mass, body composition, waist circumference, and HDL-C(35).

3. Maintaining a healthy weight
Over weight or obesity can cause increased risk of coronary heart diseases. Dr. Park YS and Dr. Kim JS. at the Sungkyunkwan University School of Medicine showed thjat WC is associated with increased CHD risk regardless of the level of BMI. Men with normal BMI and obese WC tend to be associated with CHD risk than those with obese BMI and obese WC(36).

4. Quitting smoking
Prevalence of smoking is increasing in women in some populations and is a risk factor for coronary heart disease. Whether mechanisms underlying the sex difference in risk of coronary heart disease are biological or related to differences in smoking behaviour between men and women is unclear. Tobacco-control programmes should consider women, particularly in those countries wheresmoking among young women is increasing in prevalence(37).

5. Moderate consumption of Green tea, coffee and alcohol
Regular consumption of moderate quantities of coffee and (green) tea seems to be associated with a small protection against CAD, results from randomized clinical trials about their beneficial effects are less evident. As for other diffuse consumption habits, such as that of alcohol, moderation is the key word. In fact, both for coffee and chocolate, the optimal healthy effects on CAD have been observed to be associated with a moderate intake, while healthy outcomes vanish at heavy consumption(38).

6. Managing stress
Music listening may have a beneficial effect on blood pressure, heart rate, respiratory rate, anxiety, and pain in persons with CHD. However, the quality of the evidence is not strong and the clinical significance unclear. Most studies examined the effects of listening to pre-recorded music. More research is needed on the effects of music offered by a trained music therapist(39). Other researchers in the study to determine the prevalence of anxiety and depressive symptoms in patients referred to a cardiology outpatient clinic for performing the stress test suggested that the prevalence of anxiety and depressive symptoms was estimated to be 42% and 31%, respectively, in the total chest pain population. Males with abnormal test were depressed but females experienced more anxiety symptoms. Patients with negative tests had significantly higher scores for anxiety and higher depression scores than those with positive tests. Eleven percent of the patients with positive tests were women and 23% were men(40).

7. Say No drug
There is a report of a 31 year old man with a 17-year-history of drug abuse (heroine and cannabis) was admitted with recurrent chest pain over a period of about three weeks. Chest discomfort severely worsened during the 5 hours before hospital admission. Electrocardiography revealed poor R-wave progression and non specific repolarization abnormalities. Echocardiography showed extensive left ventricular anterior and apical wall motion abnormalities and a ventricular thrombus located at the apex of the left ventricle was present. Subsequently, a diagnosis of acute coronary syndrome was made(41).

8. Relaxation
In the study to observe the effect of regular yogic practices and self-discipline in reducing body fat and elevated lipids in CAD patients, showed that Reduction of SBP, DBP, heart rate, body fat%, total cholesterol, triglycerides and LDL after regular yogic practices is beneficial for cardiac and hypertensive patients. Therefore yogic practices included in this study are helpful for the patients ofcoronary artery disease(42).
9. Etc.

Obesity and Obesity's complication - The association of Obesity on Urinary Incontinence

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Urinary Incontinence
Urinary incontinence is defined as a condition of involuntary leakage of urine when under stress late stage of pregnancy, obesity, etc.

The association of Obesity with Urinary Incontinence
1. According to the study of "Risk Factors for the Development of StressUrinary Incontinence in Women" by Stothers L, Friedman B. (Source from University of British Columbia, Vancouver, British Columbia, V5Z 1M9, Canada, lynns@interchange.ubc.ca, Curr Urol Rep. 2011 Sep 22. [Epub ahead of print]). posted in PubMed, researchers indicated that Obesity is an increasingly prevalent health condition that was shown to have detrimental impact on SUI (Stress urinary incontinence) development, while weight reduction was proven to reduce SUI.

2. According to the research of "Obesity and smoking: Are they modulators of cough intravesical peak pressure in stress urinary incontinence?" by Fuganti PE, Gowdy JM, Santiago NC. (Source from Hospital de Câncer de Londrina, Parana, Brazil. Int Braz J Urol. 2011 Jul-Aug;37(4):528-33.), posted in PubMed, researchers found that Obesity and smoking showed increased CIPP (maximal Intravesical Peak Pressures generated by Cough). While reduced BMI is related to lower CIPP, smoking cessation does not appear to diminish CIPP. These findings suggest that weight loss may reduce incontinence by CIPP modulation. However, the benefits of smoking cessation without additional lifestyle modification, may have no benefit to improve urinary incontinence.

3. In a study of "Prevalence and trends of urinary incontinence in adults in the United States, 2001 to 2008", by Markland AD, Richter HE, Fwu CW, Eggers P, Kusek JW (Source from Birmingham/Atlanta Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.35249-7333, USA), post in PubMed, researchers found that The age standardized prevalence of urinary incontinence increased in men and women from 2001 through 2008. Decreasing obesity and diabetes may lessen the burden of urinary incontinence, especially in women.

4. In the abstract of the stuyd of "The prevalence of urinary incontinence and its burden on the quality of life among older adults with medicare supplement insurance" by Hawkins K, Pernarelli J, Ozminkowski RJ, Bai M, Gaston SJ, Hommer C, Migliori RJ, Yeh CS. (Source from Health Care Innovation and Information, Ingenix, 5430 Data Court, Ann Arbor, MI 48108, USA. Kevin.Hawkins@Ingenix.com, Qual Life Res. 2011 Jun;20(5):723-32. Epub 2010 Dec 8.), posted in PubMed, researchers indicated that Of the 5,530 eligible respondents, 37.5% reported having UI. The strongest predictors of UI were female gender, advancing age, and obesity. All the QOL estimates were significantly lower for those with UI (P < 0.001). Further, UI had a stronger influence on QOL than did diabetes, cancer, and arthritis, particularly from a mental health standpoint.

5. Etc.

Treatments of Obesity and Urinary continence
1. According to the study of "Obesity and weight management in the elderly"by Han TS, Tajar A, Lean ME. (Source from Department of Diabetes and Endocrinology, Ashford and St Peter’s NHS Trust, Chertsey, Surrey, UK., Br Med Bull. 2011;97:169-96. Epub 2011 Feb 16.), posted in PubMed, researchers found that A large number of clinical consequences of overweight and obesity are particularly problematic for elderly individuals, including type 2 diabetes mellitus, arthritis, urinary incontinence and depression. Obesity, and specifically sarcopenicobesity, should also be prevented not only from younger age, but also during major life transitions including retirement, to improve better health outcomes and quality of life in later years, with a focus on those in 'obese families', where the main increases in obesity are located. Randomized controlled trials to determine health benefits and risks from long-term weight management in obese elderly are necessary.

2. In an abstract of the study of `[Sub-urethral sling in the treatment of femaleurinary incontinence: which? how?]` [Article in French] by Debodinance P, Hermieu JF. (Source Service de Gynécologie-Obstétrique, GCS Flandre-Maritime, avenue de la Polyclinique, 59760 Grande-Synthe, France. ph.debodinance@wanadoo.fr, Gynecol Obstet Fertil. 2010 Oct;38(10):607-19. Epub 2010 Sep 28.), posted in PubMed, researchers stated that Without adequate clinical trials proving their efficacy and safety, the mini-bands can so far be recommended to treat female stress urinary incontinence. Moderate overweight does not affect the results of laying tape. In patients with severe obesity, surgery to correct obesity is even better than surgery for incontinence. Age is not a contra-indication. If the patient is young and nulliparous,...

3. In a study of `Effect of weight loss on urinary incontinence in overweight and obese women: results at 12 and 18 months`by Wing RR, West DS, Grady D, Creasman JM, Richter HE, Myers D, Burgio KL, Franklin F, Gorin AA, Vittinghoff E, Macer J, Kusek JW, Subak LL; Program to Reduce Incontinence by Diet and Exercise Group. (Source from The Miriam Hospital, Warren Alpert Medical School at Brown University, Providence, Rhode Island 02903, USA. .rwing@lifespan.org, 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved), posted in PubMed, researchers concluded that Weight loss intervention reduced the frequency of stress incontinence episodes through 12 months and improved patient satisfaction with changes in incontinence through 18 months. Improving weight loss maintenance may provide longer term benefits for urinary incontinence.

4. According to the study of `Improving urinary incontinence in overweight and obese women through modest weight loss`by Wing RR, Creasman JM, West DS, Richter HE, Myers D, Burgio KL, Franklin F, Gorin AA, Vittinghoff E, Macer J, Kusek JW, Subak LL; Program to Reduce Incontinence by Diet and Exercise. ( Source from Miriam Hospital, Providence, Rhode Island 02903, USA.), posted inPubMed, researchers found that Weight losses between 5% and 10% of body weight were sufficient for significant urinary incontinence benefits. Thus, weight loss should be considered as initial treatment for incontinence in overweight and obese women.

5. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Most Common Diseases of Men of 50Plus - Testosterone Deficiency - The Complication of Heart Diseases

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

I. Introduction
Testosterone and Testosterone deficiency
Testosterone is a male hormone. Besides promoting libido it has other important functions such as maintaining muscle mass, forming bone, and regulating heart muscle and cholesterol. It also helps to improve the oxygen levels throughout the body as well as controlling blood glucose and strengthening the immune system. Starting at age 40, levels of testosterone start to diminish, the levels of the by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT thus triggering low levels of testosterone.

Heart Disease
Most heart diseases are caused by aging as the levels of testosterone decreases as well as others such as high blood pressure which contributes to hardening of the arteries, high levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat. All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

II. Heart Diseases caused by testosterone deficiency
The heart has many testosterone receptor sites that helps to support the muscle building of the heart and protein synthesis, as well as coronary artery dilation, and maintains healthy cholesterol. As men age, the levels of testosterone decreases which weakens the heart muscle. Study shows that symptoms and EKG measurement improve when low testosterone are increased.

III. The effects of heart disease caused by testosterone deficiency
1. Blood pressure rises.
The drop of testosterone in men may eventually cause the estrogen levels to be higher than the testosterone levels resulting in high blood pressure.

2. Coronary artery elasticity diminishes.
Since testosterone is not only responsible for maintaining heart muscle protein synthesis, it is also a promoter of coronary artery dilation. The dropping of levels of testosterone as a result of the heart no longer maintaining the function of artery dilation and artery elasticity diminishes.

3. Rising of bad cholesterol, fibrinogen and triglycerides.
Since the heart is weakened caused by low levels of testosterone, the heart is no longer able to maintain its function as cholesterol, fibrinogen and triglycerides resulting in cholesterol build up in the arteries and high levels of fibrinogen and triglycerides in the bloodstream.

4. Insulin resistance.
Low levels of testosterone causes malfunction of the receptor site resulting in cells unable to take in food particles through points of receptor sites.

5. Abdominal fat increases.
Fat cells create aromatase enzymes that contribute to fat build up and low levels of testosterone that allows the forming of abdominal fat that produces more aromatase enzyme resulting in more formation of estrogen. It also causes insulin resistance by increasing fat around the stomach/waist area and fat mass.

6. Human growth hormone declines.
Levels of testosterone declines as men age.

IV. Prevention and treatment
The natural remedies uses included
1. Raw dark green leaf juice
The fresh raw dark green leaf juices are vitally important in the nutritional treatment of testosterone deficiency and Alzheimer's disease. Raw dark green leaf juice contains high amounts of vitamin C, bioflavonoids, carotenoids, and living plant enzymes to aid digestion & vitamin K resulting in cleansing of liver toxins as well as strengthening the immune system, helping to detoxify your body resulting in reversing the progressing of aging and other form of diseases.

2. Cold water fish
Besides plenty of omega 3, cold water fish is an excellent source of vitamin A and zinc that helps the binding of sex hormones, specifically testosterone and estradiol.

3. Oyster and crustaceans
Oyster and crustaceans contain high levels of magnesium and zinc that is a natural aromatase inhibitor playing a key role in regulating testosterone levels as well as improving circulation of blood to the penis vessels.

4. Saw palmetto
Saw palmetto helps to promote prostate health and increase sexual stimulation. It also helps estrogen and estrogen receptor activity resulting in a healthy hormone balance, thus increasing the levels of testosterone in men.

5. Muira Pauma
Muira pauma are stems and roots of a ptychopetalum plant in South America. It has been used as an aphrodisiac, tonic and cure for muscle paralysis and strengthening the liver function that helps to cure the hormone imbalance in aging men. Study shows that muira pauma is a libido enhancer.

6. Cinnamon Bark
The sweet and spicy taste of cinnamon bark is considered to have a very hot energy. In Chinese medicine, cinnamon bark increases the Yang energy and sexual vitality.

7. Ginkgo biloba
Unlike aspirin, Ginkgo biloba will not cause upset stomach and internal bleeding. Also, Ginkgo biloba can improve blood circulation. Be sure not to take Ginkgo seeds because they are toxic and can cause seizures.

8. Zinc and iron
Zinc and iron together helps to increase oxygen levels, produce more red blood cells, as well as aiding the circulation of the bloodstream.

9. Lutein
Study shows that people that have alot of lutein in their blood stream see no increase in the thickness of their carotid arteries. That means LDL cholesterol have not oxidized causing formation of dangerous plaque at their arteries wall leading to heart attacks and lowering cholesterol levels.

10. Chorella
Chlorella containing beta carotene, chlorophyll and other many nutritional supplements is a powerful antioxidant that helps to strengthen the immune system by blocking the formation of free radicals, improving oxygen levels for cell needs and nitric oxygen stimulating the enlargement of penis through sexual desire and detoxifying your liver as well as the entire body.

11. Fiber
Fiber can be soluble or insoluble. As we mentioned in a previous article, soluble fiber can lower your LDL and raise your HDL cholesterol while insoluble fiber has no effect on cholesterol but promotes regular bowel movements. The intake of fatty foods causes the liver to release bile into the intestines to break down the fat. The soluble fiber will help eliminate the bile instead of returning it to the blood resulting in reduced amounts of cholesterol in the blood.

12. Onions and garlic
Garlic and onions contain high amounts of sulfur compounds that not only help to improve circulation of blood but also help to keep your platelets from clumping together. Daily consumption of both garlic and onions help to keep blood pressure and cholesterol levels in healthy range. Be sure to talk to your doctor if you are taking any blood thinner medicines.

13. L-Arginine
L-Arginine helps to increase the production of nitric oxide in our body, this has an anti-angina and anti-stress effect upon the arteries enabling the muscles in the arterial walls to relax. L-Arginine also helps to prevent the build up of plaque on the arterial walls. L- Arginne taken either orally or intravenously has been found to prevent and reverse atherosclerosis, improving the functional status of heart failure and increasing blood flow in heart disease patients.

14. Taurine
Taurine is an amino acid that acts as an antioxidant helping to fortify cardiac contraction and enhance the outflow of blood from the heart. Intake of taurine will reduce the risk of congestive heart failure and arteriosclerosis.

14. Flax seeds
Flax seeds contain high amounts of alpha-linoenic acid that helps to lower high blood pressure and the risk of stroke. Eating too much flax seeds will cause gas to build up if you are not used to it.

15. Cayenne
Cayenne stimulates blood flow, and strengthens the heart's metabolism. It also helps to improve blood circulation as well as the digestive and immune systems. Cayenne contains high amounts of beta-carotene, cobalt, essential fatty acids, niacin and zinc that helps circulatory stimulation, blood purification, detoxification and fatigue.

16. Du zhong (rubber tree bark)
Du zhong is consider the primary herb used to increase the yang function in the body resulting in benefits of the heart.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

The Obesity' Research and Studies - Supplementation with conjugated linoleic acid for 24 months and Body fat mass in healthy, Overweight humans

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Common Weight Loss Herbs

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

The Treatments

In Weight Loss Perspective
Weight loss(733)(734) for obese patients is one of most vital factor to reduce PCOs symptoms(735)(737) and risk of PCOs complications(736)(737). Some researchers found that 5-10% of weight low will improve PCOs features(737) by 25%, including pregnancy(738). How can you lose weight and maintain healthybody for a healthy conception?

The Common Weight Loss Herbs

Epidemiological studies, linking herbal medicine, in induction of weight loss have been inconclusive.
Some researchers suggested that intake of certain herbal medicine may enhance appetite suppression. According to the Georgetown University Medical Center, average daily food intake was decreased only with the herbal formulation, not the phenylpropanolamine (PPA) at the low and high doses, in comparison of the effectiveness among herbal formulation and a commonly available(780). Other researchers insisted that using herbs and supplements to induce weight loss should be taken with care, as a considerable number of reports have been published on hepatotoxicity associated with herbal products attributed with weight-reducing properties(781)(782)(783)(784). The College of Medicine, The Ohio State University insisted that various dietary, lifestyle, and psychologic factors are involved in the etiology of Prameha, particularly in relation to disturbances in fat and carbohydrate metabolism(785), without effective management, obtaining a workable weight loss plan may be extremely difficult.

1. Ephera (Ma Huang)
Ma Huang is also known as ephedra. The acrid, slightly bitter and warm herb has been used in TCM to promote urination and sweating, and rid of cold, sooth wheezing asthma, etc. as it calms dyspnea, asthma, cough, etc., by enhancing the functions of lung and bladder channels(786)
Ephedra sinica, the Chinese herb may be effective in induced weigh loss. According to the Dongguk University, certain chemicals found in Ephera showed an association with changes of BW and BMI through alteration of gut microbiota varied by indigenous microbiota of each subject(787). The combined study of a low-calorie diet and Ephera, In 125 otherwise healthy obese women, showed effectively in reducing BMI. RMR change not compensated for by the herbal medicines tried. Resting metabolic rate (RMR) change seemed to be affected by constitution and body composition rather than by medicine(788). The Dongeui University study of composition GGEx18( Laminaria japonica, Rheum palmatum, and Ephedra sinica) in high fat diet-induced obese mice suggested that GGEx18 improves obesity through skeletal muscle AMPK and AMPK-stimulated expression of PPARα and its target enzymes for fatty acid oxidation, through inhibited lipid accumulation, and similar activation of genes(789).
Please note that due to its adverse reactions of palpitations, stress, headache and insomnia and stroke, heart attacks, cardiac arrhythmias, seizures and psychotic, the Dutch Inspectorate for Health Care and the Ministry of Health in Canada have recently requested a market recall of some ephedrine-containing herbal products in response to above adverse reactions. In the Netherlands, the status of Ephedra-containing products is currently reconsidered(790).

2. Ginseng
Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root)(791).
In 10 obese middle-aged Korean women who took Panax ginseng extracts for 8 wk, showed effectively in influence on gut microbiota in promoting weigh loss but depending to the composition of gut microbiota prior to ginseng intake(792). In mice fed on a high-fat diet, ginseng saponin and ginsenosides not only exerted anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems, but also promoted anti-obesity effects, through abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism(793).

3. Zingiber Officinale(Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil. It has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.(794).
According to the Tehran University of Medical Sciences, Slimax (extract of several plants including Zingiber officinale and Bofutsushosan) showed a significant decrease in body weight or inhibition of weight gain(795). The composition of multi-ingredient supplement containing primarily raspberry ketone, caffeine, capsaicin, garlic, ginger and Citrus aurantium, also found the improvements in body composition, waist and hip girth, in an eight-week diet and exercise weight lossprogram(796). In a comparison of the weight loss effect of Orlistat, a pharmacological agent promoting weight loss and ginger (Zingiber officinaleRoscoe, Zingiberacae) in male albino rats, researchers at the Ain Shams University Cairo, found that ginger has a great ability to reduce body weight without inhibiting pancreatic lipase level, or affecting bilirubin concentration, with positive effect on increasing peroxisomal catalase level and HDL-cholesterol(797).

4. Cissus quadrangularis (CQ)
Cissus quadrangularis is an ancient herb used to treat a variety of indications, belonging to the grape family, probably native to India or Sri Lanka. A randomized, double-blind, placebo-controlled design involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19-50). conducted by University of Yaoundé I, Cissus quadrangularis showed a statistically significant net reductions in weight and central obesity, as well as causes of metabolic syndrome(798). In comparison of the effectiveness of Cissus quadrangularis-only and a Cissusquadrangularis/Irvingia gabonensis combination, on weight loss in overweight and obese human subjects, Cissus quadrangularis-only group showed significant reductions on all variables compared to the placebo group, the Cissusquadrangularis/Irvingia gabonensis combination resulted in even larger reductions(799). CQR-300, a proprietary extract of Cissus quadrangularis, also showed a significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors, according to the University of Yaoundé I,(800).

5. Sambucus nigra
Elder also known as Common Elder, is a shrub or small tree of the genus Sambucus of 30 specie, belonging to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere. The herb has been used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.
The composition of supplement with Sambucus nigra and Asparagus officinalis study, showed an effectiveness in reduced weight, blood pressure, enhanced physical and emotional well-being and the quality of life had significantly improved (ITT analysis)(801). The Tehran University of Medical Sciences, Sambucus nigra study, showed a significant decrease in body weight in numbers of animal studies(802).

6. Asparagus officinalis
Asparagus is a flowering plant belong to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia. Asparagus has been used from early times as a vegetable and medicine, because of its delicate flavour and diuretic properties(803). Asparagus officinalis L. powder tablets provided 19 mg saponins per day study showed an effectiveness of the tablets in reduced mean weight, blood pressure, and enhanced physical and emotional well-being and the quality of life with the rate of very good or good by most of the completers(804). In 12 weeks supplementation of a botanical extract-based weight loss formula, includingAsparagus, researchers at the Poznan University of Medical Science, indicated a significantly change of the Body Composition Improvement Index (BCI), induce greater weight loss than placebo, probably through a concurrently performed exercise program recommended strategy for life style modification(805).

7. Slimax
Slimax (extract of several plants including Zingiber officinale and Bofutsushosan), in the reviews of the data base of studies published, showed a significant decrease in body weight. In 41 animal studies, the formula was found to be effective in significant induced weight loss or inhibited of weight gain(806).

Taken altogether, the above herbs may be effectiveness in enhanced weight loss through suppression of appetite and improvement of symptoms induced by over weight and obesity. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying

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(781) Pistachio nuts reduce triglycerides and body weight by comparison to refined carbohydrate snack in obese subjects on a 12-week weight loss program by Li Z1, Song R, Nguyen C, Zerlin A, Karp H, Naowamondhol K, Thames G, Gao K, Li L, Tseng CH, Henning SM, Heber(PubMed)
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(785) Multinutrient supplement containing ephedra and caffeine causes weight lossand improves metabolic risk factors in obese women: a randomized controlled trial by Hackman RM1, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL.(PubMed)
(786) Ma Huang(Popular Chinese herbs)
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(791) Ginseng, Asian (Panax ginseng) and Ginseng, North America(Popular Chinese Herbs)
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(794) Popular #Herbs - #Ginger (Zingiber officinale)(Popular Chinese herbs)
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(803) #Healthy #Foods - Vegetables - Asparagus (Asparagus officinalis)(health tips for better living and living health)
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Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs – Ban Mao (Mylabris phalerata)

Ingredients
1. F canthavidin
2. Hydroxycanthavidin
3. Phosphorus
4. Magnesium
5. Calcium
6. Fat
7. Odorous substance
8. Etc.

Health Benefits
1. Anti cancers
The components of the butanol (BuOH) fraction of MP (BFMP) of Mylabris phalerata (MP) is an insect that has been used for the treatment of cancer in oriental medicine, have demonstrated the anti-cancerous activities in inhibition of human monocytic leukemic U937 cells, induction of the morphological changes of apoptosis, such as chromatin condensation, cell shrinking and DNA fragmentation at a concentration of 31.25 microg/ml. etc., according to the study of “Mylabris phalerlata induces apoptosis by caspase activation following cytochrome c release and Bid cleavage” by Huh JE, Kang KS, Ahn KS, Kim DH, Saiki I, Kim SH.(1).

2. Colorectal cancer
Norcantharidin (NCTD) derived from a renal toxic compound cantharidin found in blister beetles (ban mao) has found to decrease reporter luciferase activity from a Sp1 construct, augmented with a NF-kappaB construct that lead to the increase effect of NF-kappaB-luciferase activity resulting in competitive suppression of NF-kappaB-binding activity in MMP-9 promoter of which suggested as a potential in treating colorectal cancer, according to the study of “small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells” by Chen YJ, Chang WM, Liu YW, Lee CY, Jang YH, Kuo CD, Liao HF.(2).

3. Anti-tumors
Cantharidin, in the form of the dried body of the Chinese blister beetles(Ban Mao) has exerted the profound cytotoxicity towards tumor cells without identifying the molecular determinants of sensitivity and resistance of tumor cells to CAN, according to the study of “Microarray-based prediction of cytotoxicity of tumor cells to cantharidin” by Efferth T.(3).

4. Alzheimer’s disease
In acetylcholinesterase (AChE) inhibition and copper ion binding effects, cantharidin from the beetle was shown to have AChE activity (31% inhibition at 1 muM, 0.196 microg mL(-1)), making it a major contributor to the activity of the beetle extract for improving cognitive function, according to the study of ‘Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer’s disease” by Ren Y, Houghton P, Hider RC.(4).

5. Cytotoxic effects
Cantharidin is isolated from Mylabris phalerata Pallas has exerted the acitivity as an inhibitor of hepatocellular by inhibiting the progression of all phases of the Hep 3B cell cycle as it reduced the numbers and replaced by numerous blebs, according to the study of “Cytotoxic effects of cantharidin on the growth of normal and carcinoma cells” by Wang CC, Wu CH, Hsieh KJ, Yen KY, Yang LL.(5).

6. Etc.

Side effects
1. Overdoses of the crude extract of cantharides from over 200 dried Mylabris phalerata can be danger and fatal , according to the study of “A fatality due to the use of cantharides from Mylabris phalerata as an abortifacient” by Cheng KC, Lee HM, Shum SF, Yip CP.(a)
2. Overdoses alos may cause burning sensation in the throat and mouth, dizziness, disgestive disorders, frequent urination, etc.
3. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/12927594
(2) http://www.ncbi.nlm.nih.gov/pubmed/19616522
(3) http://www.ncbi.nlm.nih.gov/pubmed/15706417
(4) http://www.ncbi.nlm.nih.gov/pubmed/16805960
(5) http://www.ncbi.nlm.nih.gov/pubmed/10874155
(a) http://www.ncbi.nlm.nih.gov/pubmed/2263179