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Ban Mao (Mylabris phalerata)
Ban Mao is also known as Blister Beetle. The acrid, cold and very toxic herb has been used in TCM as Anti-tumor, Anti-virus, anti-inflammatory, anti-fungul agent and to enhance the production of white blood cell count, inhibit the liver damage and enhances androgens and immune system, etc. as it expels toxins, eliminates Blood accumulation and stagnation, etc. by promoting the functions of liver, kidney, stomach, large intestine, small intestine channels.
1. F canthavidin
7. Odorous substance
1. F canthavidin
7. Odorous substance
1. Anti cancers
The components of the butanol (BuOH) fraction of MP (BFMP) of Mylabris phalerata (MP) is an insect that has been used for the treatment of cancer in oriental medicine, have demonstrated the anti-cancerous activities in inhibition of human monocytic leukemic U937 cells, induction of the morphological changes of apoptosis, such as chromatin condensation, cell shrinking and DNA fragmentation at a concentration of 31.25 microg/ml. etc., according to the study of “Mylabris phalerlata induces apoptosis by caspase activation following cytochrome c release and Bid cleavage” by Huh JE, Kang KS, Ahn KS, Kim DH, Saiki I, Kim SH.(1).
2. Colorectal cancer
Norcantharidin (NCTD) derived from a renal toxic compound cantharidin found in blister beetles (ban mao) has found to decrease reporter luciferase activity from a Sp1 construct, augmented with a NF-kappaB construct that lead to the increase effect of NF-kappaB-luciferase activity resulting in competitive suppression of NF-kappaB-binding activity in MMP-9 promoter of which suggested as a potential in treating colorectal cancer, according to the study of “small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells” by Chen YJ, Chang WM, Liu YW, Lee CY, Jang YH, Kuo CD, Liao HF.(2).
Cantharidin, in the form of the dried body of the Chinese blister beetles(Ban Mao) has exerted the profound cytotoxicity towards tumor cells without identifying the molecular determinants of sensitivity and resistance of tumor cells to CAN, according to the study of “Microarray-based prediction of cytotoxicity of tumor cells to cantharidin” by Efferth T.(3).
4. Alzheimer’s disease
In acetylcholinesterase (AChE) inhibition and copper ion binding effects, cantharidin from the beetle was shown to have AChE activity (31% inhibition at 1 muM, 0.196 microg mL(-1)), making it a major contributor to the activity of the beetle extract for improving cognitive function, according to the study of ‘Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer’s disease” by Ren Y, Houghton P, Hider RC.(4).
5. Cytotoxic effects
Cantharidin is isolated from Mylabris phalerata Pallas has exerted the acitivity as an inhibitor of hepatocellular by inhibiting the progression of all phases of the Hep 3B cell cycle as it reduced the numbers and replaced by numerous blebs, according to the study of “Cytotoxic effects of cantharidin on the growth of normal and carcinoma cells” by Wang CC, Wu CH, Hsieh KJ, Yen KY, Yang LL.(5).
1. Overdoses of the crude extract of cantharides from over 200 dried Mylabris phalerata can be danger and fatal , according to the study of “A fatality due to the use of cantharides from Mylabris phalerata as an abortifacient” by Cheng KC, Lee HM, Shum SF, Yip CP.(a)
2. Overdoses alos may cause burning sensation in the throat and mouth, dizziness, disgestive disorders, frequent urination, etc.
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