Medical Advisor Journals

Tuesday, June 14, 2016

Herbal therapy: Popular Herbal Goldenrod

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Goldenrod

Goldenrod, is one of the flowering plants, genus Solidago, belonging to the family Asteraceae, native to to Mexico, South America, and Eurasia. The herb has been used in traditional medicine to treat bladder inflammation, arthritis, allergies, colds and flu, kidney stones, etc.

Health benefits
1. Antibacterial activities
In the investigation of Nine clerodane diterpenes, solidagoic acids C-I (1-7), cleroda-3,13(14)-dien-16,15:18,19-diolide (8) and cleroda-3,13(14)-dien-15,16:18,19-diolide (9) were isolated and characterised from the ethanol-ethyl acetate (1:1) extract of Solidago virgaurea found that Several displayed moderate antibacterial activity against Staphylococcus aureus, acording to "Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)" by Starks CM, Williams RB, Goering MG, O'Neil-Johnson M, Norman VL, Hu JF, Garo E, Hough GW, Rice SM, Eldridge GR.(1)

2. Anti-inflammatory and antirheumatic effects
In the assessment of A combination of Populus tremula, Solidago virgaurea and Fraxinus excelsior and theirs spasmolytic, antihypertensive and diuretic effects found that in vitro and especially in vivo studies proved its anti-inflammatory and antirheumatic properties, often comparable to non-steroidal anti-inflammatories, but with little or no side effects, according to "A combination of Populus tremula,Solidago virgaurea and Fraxinus excelsior as an anti-inflammatory and antirheumatic drug. A short review" by von Kruedener S, Schneider W, Elstner EF.(2)

3. Antioxidative properties
In the evaluation of macromolecular glycoconjugates from selected herbal plants of Asteraceae family: Achillea millefolium L., Arnica montana L., Echinacea purpurea L., Solidago virgaurea L., Chamomilla recutita (L.) Rauschert., and Conyza canadensis L. protect platelet proteins against nitrative and oxidative damage induced by peroxynitrite, found that that the compounds from herbal plants: A. millefolium, A. montana, E. purpurea, C. recutita, S. virgaurea, possess antioxidative properties and protect platelet proteins against peroxynitrite toxicity in vitro, similar to the glycoconjugates from C. canadensis. However, in the comparative studies, the polyphenolic-polysaccharide conjugates from selected tested medicinal plants were not found to be more effective antioxidant, than the solution of pure resveratrol, according to "The effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of Asteraceae family on the peroxynitrite-induced changes in blood platelet proteins" bySaluk-Juszczak J, Pawlaczyk I, Olas B, Kołodziejczyk J, Ponczek M, Nowak P, Tsirigotis-Wołoszczak M, Wachowicz B, Gancarz R.(3)

4. Kidney stone
In the observation of goldenrod (Solidago virgaurea L.) and its effect on the treatment of urinary tract diseases found that The use of such herbal preparations with a rather complex action spectrum (anti-inflammatory, antimicrobial, diuretic, antispasmodic, analgesic) is especially recommended for treatment of infections and inflammations, to prevent formation of kidney stones and to help remove urinary gravel. This therapy is safe at a reasonable price and does not show drug-related side-effects, according to "[Goldenrod--a classical exponent in the urological phytotherapy].[Article in German]" by Melzig MF.(4)

5. Anti Prostatic tumor
In the investigation of Solidago virgaurea (goldenrod) and its effect on prostatic diseases found that the growth of the tumor was significantly suppressed by the G-100 fraction at 5 mg/kg without any apparent side effects. Therefore, S.virgaurea is considered to be promising as an antineoplastic medicine with minimal toxicities, according to "Antineoplastic activity of Solidago virgaurea on prostatic tumor cells in an SCID mouse model" by Gross SC, Goodarzi G, Watabe M, Bandyopadhyay S, Pai SK, Watabe K.(5)

6. Bladder dysfunction
In the observation of Extracts from Rhois aromatica and Solidaginis virgaureainhibit rat and human bladder contraction.found that extracts from Rhois aromatica and Solidaginis virgaurea inhibit muscarinic receptor-mediated contraction of rat and human bladder. While this could contribute to the beneficial effects of these extracts in patients with bladder dysfunction, such therapeutic effects remain to be demonstrated in controlled clinical studies, according to "Extracts from Rhois aromatica and Solidaginis virgaurea inhibit rat and human bladder contraction" by Borchert VE, Czyborra P, Fetscher C, Goepel M, Michel MC.(6)

7. Antifungal activities
In the Glycosides of polygalacic acid (2 beta,3 beta,16 alpha,23-tetrahydroxy-olean-12-ene-28-oic acid) is isolated from the aerial parts of Solidago virgaurea and other herb found that The antifungal action can be influenced the variation of the etherglycosidically bonded carbohydrate units at C-3 as well as of the acylglycosidically bonded oligosaccharide at C-28 of the aglycone, according to "Cytotoxicity of triterpenoid saponins. Part 2: Relationships between the structures of glycosides of polygalacic acid and their activities against pathogenic Candida species" by Bader G, Seibold M, Tintelnot K, Hiller K.(7)

8. Immunomodulatory and antitumoral effects
In the study of Genuine saponins of Solidago virgaurea L., Heteropappus altaicus (Willd.) Novopokr., Heteropappus biennis (Ldb.) Tamamsch. and Helianthus annuus L. (Asteraceae) as well as related carbohydrate modified glycosides of polygalacic acid and echinocystic acid and some commercial available triterpenoid saponins and theirs immunomodulating and antitumoral effects found that in vivo antitumoral effects in the allogeneic sarcoma 180 tumor model and in the syngeneic DBA/2-MC.SC-1 fibrosarcoma tumor model. In mice, treated with 1, phagocytosis of bone marrow cells and proliferation of spleen and bone marrow cells were stimulated in an ex vivo assay whereby the TNF alpha concentration in blood considerably increased compared to the control group, according to "Immunomodulatory and antitumoral effects of triterpenoid saponins" by Plohmann B, Bader G, Hiller K, Franz G.(8)

9. Antioxidative properties
In the demonstration of Aqueous-ethanolic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea and theirs anti inflammatory effects found that The tested extracts are the components of the phytomedicine Phytodolor N (abbreviated as PD) which possesses antipyretic, analgesic, antiinflammatory and antirheumatic activity. Since several reactive oxygen species produced by the mentioned model systems are also involved in inflammatory processes, the beneficial activities of the complete drug may at least in part be due to the reported antioxidative functions of the individual components, according to "Antioxidative properties of alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea" by Meyer B, Schneider W, Elstner EF.(9)

10. Etc.

Side effects
1. Do not use the herb if you are pregnant or have heart or kidney disease.
2. No other side effects if not overdosed.

Most Common Diseases of Men of 50Plus - Erectile Dysfunction Prevention and Treatment - The Diet

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica) Treatment: The Individual herb - Cat's claw

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Polymyalagia Arthritis (Rheumatica)

Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

Treatments

B.2. Herbal and Traditional Chinese medicine
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including
B.2.1. The Individual Herbs
8. Cat's claw
Cat's claw (Uncaria tomentosa), the very common herbal medicine, has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.(462,218).
Recently, according to the study by Case Western Reserve University, herbal and amino acid mixture containing extract of the Uncaria tomentosa, may be potentially useful as a new adjunct therapeutic/preventive agent for Arthritis or injury recovery effectively, due to its anti inflammatory(464,219) and chondroprotective activities, in up-regulation of ACAN and COL2A1 expression in IL-1β-stimulated and inhibiting the activation of nuclear factor (NF)-kB in human OA chondrocytes(463,220) as well as reducing of pro-inflammatory mediators and effectors(464,221).

The Facultad de Medicina, in the comparison of the species U guianensis and U tomentosa, found that both herbal medicine are effective in treatment of arthritis, probably through its anti-inflammatory properties in inhibited TNFalpha and PGE2 production(465,222).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(462,218) Cat's claw (Uncaria tomentosa) by Kyle J. Norton
(464,219) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR1.(PubMed)
(463,220) Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes by Akhtar N1, Miller MJ, Haqqi TM.(PubMed)
(464,221) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR1.(PubMed)
(465,222) Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis by Piscoya J1, Rodriguez Z, Bustamante SA, Okuhama NN, Miller MJ, Sandoval M.(PubMed)

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs – Ban Zhi Lian (Herba Scutellriae Barbatae)

Ingredients
1. Scutellarein
2. Scutellarin
3. Carthamidin
4. Isocarthamidin
5. Alkaloid
6. C30H36O7N2
7. β-sitosterol
8. Stearic acid
9. Etc.

Health Benefits
1. Cytotoxic activities: 17 flavonoids, isolated from two flavonoid-rich Scutellaria species has exerted the inhibition of the proliferation of HL-60 and the proliferation of some cancer cell lines, according to the study of “Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine” by Sonoda M, Nishiyama T, Matsukawa Y, Moriyasu M.(1).

2. Metastatic breast cancer: Aqueous extract from the herb Scutellaria barbata (Ban Zhi Lian), maximum tolerated dose (MTD) of BZL101 (FDA IND# 59,521) has demonstrated the anti tumors activity in three patients with objective tumor regression (>0% and <30%), according to the study of “A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer” by Perez AT, Arun B, Tripathy D, Tagliaferri MA, Shaw HS, Kimmick GG, Cohen I, Shtivelman E, Caygill KA, Grady D, Schactman M, Shapiro CL.(2).

3. Oxidative stress: Bezielle (BZL101) is an orally administered aqueous extract of Scutellaria barbata has demonstrated the cytotoxicity activity toward cancer cells is primarily based on inhibition of metabolic pathways that are preferentially activated in tumor cells thus explaining its specificity for cancer cells, according to the study of ‘Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: A combined proteomic and metabolomic study” by Klawitter J, Klawitter J, Gurshtein J, Corby K, Fong S, Tagliaferri M, Quattrochi L, Cohen I, Shtivelman E, Christians U.(3).

4. Prostate Cancer: Bedside proven as a effective herb in treating breast cancer, BZL101, the aqueous extract of Scutellaria barbata has also arrests early stage androgen sensitive LNCaP cells in the G₂/M phase with corresponding decreases in Cyclin B1, CDK1 and androgen receptor expression. In late stage hormone insensitive breast and prostate (PC3) cancer cells,m according to the study of “BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype” by Marconett CN, Morgenstern TJ, San Roman AK, Sundar SN, Singhal AK, Firestone GL.(4).

5. Anti-complementary Diseases: The polysaccharide was extracted and purified from Herba Scutellariae Barbatae has demonstrated the ability inhibited complement activation of the classic pathway and may be considered as a candidate in treating those complement-associated diseases such as rheumatoid arthritis, Alzheimer’s disease, and Adult Respiratory Distress Syndrome (ARDS), according to the study of “Anti-complementary effect of polysaccharide B3-PS1 in Herba Scutellariae Barbatae (Scutellaria barbata)” by Wu Y, Chen DF.(5).

6. Liver caner: Extracts of Scutellaria barbata D.Don (S. barbata) has showed the activities in inhibition the proliferation of H22 cells in a time-dependent manner, according to the study of “Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3” by Dai ZJ, Wang XJ, Li ZF, Ji ZZ, Ren HT, Tang W, Liu XX, Kang HF, Guan HT, Song LQ.(6).

(7) Etc.

Side Effects
1. Do not use the herb if you are preganat or breast feeding without consulting with the related field specialist
2. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/15036470
(2) http://www.ncbi.nlm.nih.gov/pubmed/20054647
(3) http://www.ncbi.nlm.nih.gov/pubmed/21509784
(4) http://www.ncbi.nlm.nih.gov/pubmed/20574166
(5) http://www.ncbi.nlm.nih.gov/pubmed/19874244
(6) http://www.ncbi.nlm.nih.gov/pubmed/19109865

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The fertility Herb Angelica sinensis

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

The prevention and management In Herbal Medicine

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.

Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).

The Fertility Herb: Angelica sinensis

Dang Qui (Angelica sinensis) is a herb of Genus Angelica from the family Apiaceae, indigenous to China, used as a Queen herb in traditional Chinese medicine as anti inflammatory(889), antispasmodic(890) and vasodilatory agent(891)(890), and to balance the hormones in women for a normal menstrual cycle and menstruation(890), reduce menopausal syndromes(888) and improve digestive system(890) and immunity(890).

1. Reproductive organs tonic
Traditional Chinese medicine views angelica roots as queen herb which has been used to enhance the productive system(892) for treatment of gynecological diseases(897) such as dysmenorrhea, amenorrhoea, menopause and promote menstrual health(892). It is said that angelica roots has the power to restore any deficiency caused by hormone imbalance(894)(895)(896).

2. Blood tonic
A reproductive blood tonic herb(894) not only help to increase blood production(895) to replace blood loss for women after menstruation(893), but also increases the blood flow to abdominal region(890)(891), for induction of healthy conception.

3. Digestive system
Dangqui consists a didestice system protective effects(898) against gastrointestinal damage, but also increases the digestive system function(890) in absorbing essential vitamins and minerals(890), thereby reducing the risks of infertility caused by nutrients deficiency(899).

4. Blood and qi deficiency
Blood(896) and qi(890)deficiency may lead to irregular menstrual cycle, absence of period or painful period(896). Angelica roots increase blood and qi flow(890), resulting in normalizing the function of reproductive organs(892)(897).

5. Kidney tonic
It is said that angelica root also helps to improve kidney function not only in regulating water and fluid through urinary extraction(900), but also improving kidney normal function in regulating the natural menstrual process(900) of the reproductive organs, induced fertility.

6. Immune system
Angelica root containing variety chemicals strengthens the immune system(903) in fighting against infection and inflammation(894)(889), thereby decreasing the risk of yeast infection during menstruation(891) as well as forming of irregular cell growth in the reproductive organs(901)(902)(903).

Side effects
1. It may cause skin inflammation and rashes, if it is taken in high dose(904)
2. Since angelica root causes uterus constraction, the herb should be used on pregnant(904) unless with the approval of her herbalist(904).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)

(889) Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation by Chao WW, Hong YH, Chen ML, Lin BF.(PubMed)
(890) Dang Qui(Complementary and Alternative Healing University)
(891) Angelica sinensis / Dong Quai(Golden Lotus Botanicals)
(892 Danggui to Angelica sinensis root: are potential benefits to European women lost in translation? A review by Hook IL1.(PubMed)
(893) Metabolomics study of hematopoietic function of Angelica sinensis on blood deficiency mice model by Li PL1, Sun HG1, Hua YL1, Ji P1, Zhang L1, Li JX1, Wei Y2(PubMed)
(894) Molecular screening of Chinese medicinal plants for progestogenic and anti-progestogenic activity by Ahmed HM1, Yeh JY, Tang YC, Cheng WT, Ou BR.(PubMed)
(895) Estrogenic activity of herbs commonly used as remedies for menopausal symptoms by Amato, Paula MD1; Christophe, Sylvie PhD2; Mellon, Pamela L. PhD(Menopause) (896) Integrated standardization concept for Angelica botanicals using quantitative NM by Received 9 July 2011, Revised 17 August 2011, Accepted 20 August 2011, Available online 1 September 2011(Sience direct)
(894) [Experimental study on effects of 18 kinds of Chinese herbal medicine for synthesis of thromboxane A2 and PGI2].[Article in Chinese] by Wang SR1, Guo ZQ, Liao JZ.(PubMed)
(895) Polysaccharide isolated from Angelica sinensis inhibits hepcidin expression in rats with iron deficiency anemia by Liu JY1, Zhang Y, You RX, Zeng F, Guo D, Wang KP.(PubMed)
(896) [Hematopoietic effect of siwu decoction in the mice with blood deficiencyinduced by compound method of bleeding, starved feeding and exhausting].[Article in Chinese] by Tan W1, Song CS, Tan HL, Liu LL, Ma ZC, Wang YG, Gao Y.(PubMed)
(897) Chemical fingerprinting and quantitative constituent analysis of Siwu decoction categorized formulae by UPLC-QTOF/MS/MS and HPLC-DAD by Shulan Su1, Wenxia Cui1 2, Wei Zhou1, Jin-ao Duan1*, Erxin Shang1 and Yuping Tang(Chinese medicine)
(898) Study of the gastrointestinal protective effects of polysaccharides fromAngelica sinensis in rats.

Cho CH1, Mei QB, Shang P, Lee SS, So HL, Guo X, Li Y.(PubMed)
(899) Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance by Samsel A1, Seneff S2.(PubMed)
(900) 36 Healing Herbs: The World's Best Medicinal Plants By Rebecca L. Johnson
(901) The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo. by Tsai NM1, Lin SZ, Lee CC, Chen SP, Su HC, Chang WL, Harn HJ.(PubMed)
(902) A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. by Cao W1, Li XQ, Wang X, Fan HT, Zhang XN, Hou Y, Liu SB, Mei QB.(PubMed)
(903) Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients by Zhuang SR1, Chiu HF, Chen SL, Tsai JH, Lee MY, Lee HS, Shen YC, Yan YY, Shane GT, Wang CK.(PubMed)
(904) Dong Quai (the University of Marryland medical center)

Obesity and Obesity's complication - The association of Obesity on Sleep Disorder

Sleep disorder (somnipathy) is a medical disorder of the sleep patterns. It’s important to understand why sleep disorder can deteriorate your health and interfere with normal physical, mental and emotional functioning as it effects your nervous system in the production of the natural hormone melatonin which is necessary for sleep and wakefulness. Polysomnography testing can help to evaluate and detect the patterns of sleep disorder.

The association of obesity with Sleep Disorder
1. In the study of "Sleep apnea: a proinflammatory disorder that coaggregates with obesity" by Mehra R, Redline S., posted in PubMed, researchers found that this article elucidates mechanistic associations among obesity, sleep apnea, and systemic inflammation; highlights interrelationships between these factors with cardiopulmonary disease; and identifies specific areas for future research directions.

2. According to the abstract of the study of "Postoperative considerations for patients with obesity and sleep apnea" by Bell RL, Rosenbaum SH., posted inPubMed, researchers stated that p apnea and obesity are prevalent and often coexisting conditions that challenge medical, anesthetic, and surgical treatment. It is essential to possess knowledge of the magnitude of the sleep disorder as well as concomitant medical comorbidities. Management of obese patients requires a thorough preoperative evaluation and appraisal of anesthetic and operative risks. Postoperatively, these patients can present an additional challenge.

3. In a study of "Obstructive sleep apnea in the adult obese patient: implications for airway management" by Benumof JL., posted in PubMed, researchers found that Obstructive sleep apnea in the adult obese patient may be due, in part, to an increased amount of pharyngeal tissue. Therefore, there is an increased risk of intubation and extubation difficulties and pain management can be expected to be complicated by opioid/sedative-induced pharyngeal collapse.

4. In the abstract of the study of "The relationship between obesity and craniofacial structure in obstructive sleep apnea" by Ferguson KA, Ono T, Lowe AA, Ryan CF, Fleetham JA., posted in PubMed, researchers that there is a spectrum of upper airway soft-tissue and craniofacial abnormalities among OSA patients: obese patients with increased upper airway soft-tissue structures, nonobese patients with abnormal craniofacial structure, and an intermediate group of patients with abnormalities in both craniofacial structure and upper airway soft-tissue structures.

5. According to the study of "Cephalometric abnormalities in non-obese and obese patients with obstructive sleep apnoea" by Sakakibara H, Tong M, Matsushita K, Hirata M, Konishi Y, Suetsugu S., posted in PubMed, researchers indicated that Japanese obstructive sleep apnoea patients have a series of cephalometric abnormalities similar to those described in Caucasian patients, and that the aetiology of obstructive sleep apnoea in obese patients may be different from that in non-obese patients. In obese patients, upper airway soft tissue enlargement may play a more important role in the development of obstructivesleep apnoea, whereas in non-obese patients, bony structure discrepancies may be the dominant contributing factors for obstructive sleep apnoea.

6. In a study of "Dentofacial characteristics as indicator of obstructive sleepapnoea-hypopnoea syndrome in patients with severe obesity" by Maciel Santos ME, Laureano Filho JR, Campos JM, Ferraz EM., posted in PubMed, researchers found that the most prevalent modified Mallampati index score was between 3 and 4, while grade 1 was the most prevalent tonsillar hypertrophy index score (46%). Cephalometry revealed angular and linear measurements with normally acceptable values for the hard tissues. Obese patients seem to have a normal craniofacial structure and the risk of developing OSAHS is especially related to obesity.

7. Etc.

Treatments of Obesity induced Sleep Disorder
1. According to the study of "Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism" by Hanlon EC, Van Cauter E., posted in PubMed, researchers indicated that... Simultaneously, average sleep times have progressively decreased. Recently, evidence from both laboratory and epidemiologic studies has suggested that insufficient sleep may stimulate overeating and thus play a role in the currentepidemic of obesity and diabetes,.... The findings provide evidence that sleeprestriction does indeed impair glucose metabolism and alters the cross-talk between the periphery and the brain, favoring excessive food intake. A better understanding of the adverse effects of sleep restriction on the CNS control of hunger and appetite may have important implications for public health.

2. In a study of "Sleep apnea and obesity" by Yu JC, Berger P 3rd., posted inPubMed, researchers wrote that Perhaps, the strongest observational evidence to support a link between sleep apnea and obesity is the similarity in age distribution of symptomatic sleep apnea and metabolic syndrome. The putative causal links between sleep apnea and each individual component of the metabolic syndrome have been extensively evaluated and have implicated bidirectional causality in certain metabolic conditions, such as obesity and sleep apnea, sleep apnea and diabetes mellitus, and obesity and diabetes mellitus. These studies collectively suggest that even modest weight loss improves OSA, and positively affects both metabolic and cardiovascular risk profiles.

3. in the abstract of the study of "Pharmacological treatment of obstructivesleep apnea", by Abad VC, Guilleminault C., posted in PubMed, researchers wrote that Obstructive sleep apnea (OSA) is a growing public health hazard fueled by the obesity epidemic and an aging population. Untreated sleep apnea can result in significant consequences both in the short-term and long-term. We need to educate the public to recognize the symptoms of sleep apnea and to publicize that effective treatments are available. Positive airway pressure therapy remains the gold standard currently in treating OSA. Alternative treatments include an oral appliance or surgical options. This paper discusses the pharmacologic treatment of sleep apnea: goals include medications to address the ventilatory control of breathing, treat co-morbid diseases, treat associated health problems/complaints, address special issues, such as anesthetic precautions, and propose future targets.

4. Etc.

The Obesity' Weight Loss Recipes: Spinach make ahead

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recipe contributed by Company Coming salads (by Jean Pare)
This is a green that can be made "the day before"

6 cups (1.5 L) spinach leaves, torn, lightly packed
1/2 cup (125ml) grated or cubed Swiss cheese
1/2 cup (125 ml) grated or cubed Cheddar cheese
2 cups (500 ml) sliced fresh mushroom
4 hard-boiled eggs, sliced

1 cup (250 ml) salad dressing (mayonnaise)
1/2 cup (125 ml) sour cream
3 tbsp. (50ml) milk
2 tsp. (10ml) lemon juice
2 tsp. (10ml) granulated sugar
1/4 cup (50ml) thinly slice green onions
4 bacon slice, cooked and crumbled

Arrange torn green spinach leaves in bottom of the medium size glass bowl. Put grated cheese on top. Spread mushrooms over cheese. Cover with sliced eggs.
In a small cream well, salad dressing, sour cream, milk, lemon juice and sugar. Stir in onions. Bread over top of salad right to the slices of bowl. Cover. Chilled overnight.
To serve remove cover, sprinkle bacon over top. Serve 8.

Romaine make ahead: Omit spinach and use Romaine lettuce in above salad. Every bit as good.

Variation: Omit salad dressing and sour cream. Add 8 oz. (250g) cream cheese mixed with1/2 cup (125 ml) sour cream.
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