Saturday, June 18, 2016

Phytochemicals in Foods - The Effects of Phytoene

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                   Phytoene 


Phytoene
is a phytochemincal in the class of Carotenes, belonging to the group of Carotenoids (tetraterpenoids), found abundantly in sweet potato, orange, etc.

Health Benefits
1. Prostate cancerIn the examination within the context of a whole food with Male Copenhagen rats fed diets containing 10% standard tomato powder, tomato enriched with lycopene or total carotenoids, standard broccoli floret, broccoli sprouts, or broccoli enriched with indole glucosinolates or selenium for 7 days, found that standard broccoli and lycopene-enriched tomato diets down-regulated prostatic glutathione S-transferase P1 mRNA expression. Different tomato diets resulted in altered hepatic accumulation of lycopene, phytofluene, and phytoene. These results demonstrate that the bioactive content of vegetables affects both tissue content of bioactives and activity of detoxification enzymes. Enhancing bioactive content of tomatoes and broccoli may enhance efficacy in the prevention of prostate cancer, according to "Feeding tomato and broccoli powders enriched with bioactives improves bioactivity markers in rats" by Liu AG, Volker SE, Jeffery EH, Erdman JW Jr.(1)

2. Macular degeneration
In the investigation of the protective effect has been attributed to carotenoids, which are one of the major classes of phytochemicals ( lycopene, followed by phytoene, phytofluene, zeta-carotene, gamma-carotene, beta-carotene, neurosporene, and lutein) in tomato, found that the possible role of lycopene and other dietary carotenoids in the prevention of age-related macular degeneration and other eye diseases is discussed, according to "Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health" by Khachik F, Carvalho L, Bernstein PS, Muir GJ, Zhao DY, Katz NB.(2)

3. Antioxidants
In the verification of verify whether the daily intake of a beverage prototype called Lyc-o-Mato((R)) containing a natural tomato extract (Lyc-o-Mato((R)) oleoresin 6 %) was able to modify plasma and lymphocyte carotenoid concentrations, particularly those of lycopene, phytoene, phytofluene and beta-carotene, and to evaluate whether this intake was sufficient to improve protection against DNA damage in lymphocytes, found that the intake of the tomato drink significantly reduced (by about 42 %) DNA damage (P<0.0001) in lymphocytes subjected to oxidative stress. In conclusion, the present study supports the fact that a low intake of carotenoids from tomato products improves cell antioxidant protection, according to "Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protection" by Porrini M, Riso P, Brusamolino A, Berti C, Guarnieri S, Visioli F.(3)

4. Low density lipoprotein (LDL) oxidation
In the investigation of the effect of carotenoids, isolated from the alga Dunaliella bardawil, in a biological system and used the in vitro low density lipoprotein (LDL) oxidation method,
found that similar to beta-carotene and alpha-tocopherol, a carotenoid algal preparation containing phytoene and phytofluene inhibited LDL oxidation. These findings and the presence of phytoene and phytofluene in human tissues suggest that they can be part of the defense system against oxidative stress, according to "A carotenoid algal preparation containing phytoene and phytoflueneinhibited LDL oxidation in vitro" by Shaish A, Harari A, Kamari Y, Soudant E, Harats D, Ben-Amotz A.(4)

5. Inflammation, immunomodulation, and oxidative stress
In the investigation of 26 healthy young volunteers. In a placebo-controlled, double-blind, crossover study, Lyc-o-Mato (5.7 mg of lycopene, 3.7 mg of phytoene, 2.7 mg of phytofluene, 1 mg of beta-carotene, and 1.8 mg of alpha-tocopherol) or a placebo drink (same taste and flavor, but devoid of active compounds) were given for 26 days, separated by a wash-out period, found that TNF-alpha production by whole blood was 34.4% lower after 26 days of drink consumption, whereas the other parameters were not significantly modified by the treatment. In turn, modest effects of the regular intake of a tomato drink, providing small amounts of carotenoids, were found on the production of inflammatory mediators, such as TNF-alpha, in young healthy volunteers. Future intervention trials in subjects with low carotenoid status and/or compromised immune system will resolve the issue of whether carotenoids modulate immune parameters in humans, according to " Effect of a tomato-based drink on markers of inflammation, immunomodulation, and oxidative stress" by Riso P, Visioli F, Grande S, Guarnieri S, Gardana C, Simonetti P, Porrini M.(5)

6. Anti cancers
In the examination of whether carotenoids inhibit signaling of steroidal estrogen and phytoestrogen which could explain their cancer preventive activity, found that beach of the tested carotenoids (lycopene, phytoene, phytofluene, and beta-carotene) inhibited cancer cell proliferation induced by either E(2) or genistein. The inhibition of cell growth by lycopene was accompanied by slow down of cell-cycle progression from G1 to S phase. Moreover, the carotenoids inhibited estrogen-induced transactivation of ERE that was mediated by both estrogen receptors (ERs) ERalpha and ERbeta. The possibility that this inhibition results from competition of carotenoid-activated transcription systems on a limited pool of shared coactivators with the ERE transcription system was tested. Although cotransfection of breast and endometrial cancer cells with four different coactivators (SRC-1, SRC-2, SRC-3, and DRIP) strongly stimulated ERE reporter gene activity, it did not oppose the inhibitory effect of carotenoids, according to "Lycopene and other carotenoids inhibit estrogenic activity of 17beta-estradiol and genistein in cancer cells" by Hirsch K, Atzmon A, Danilenko M, Levy J, Sharoni Y.(6)

7. Anti-inflammatory effects
In the investigation of the effects of CoQ10 and colorless carotenoids (phytoene and phytofluene, or to combinations of these antioxidants) on the production of inflammatory mediators in human dermal fibroblasts treated with UV radiation (UVR) and the possible synergistic effects of these two antioxidants, found that CoQ10 is able to suppress the UVR- or IL-1-induced inflammatory response in dermal fibroblasts. Furthermore, this compound can block the UVR induction of the matrix-eroding enzyme, MMP-1. Finally, the combination of carotenoids plus CoQ10 results in enhanced suppression of inflammation. The results suggest that the combination of carotenoids and CoQ10 in topical skin care products may provide enhanced protection from inflammation and premature aging caused by sun exposure, according to "Anti-inflammatory effects of CoQ10 and colorless carotenoids" by Fuller B, Smith D, Howerton A, Kern D.(7)

8. Etc.
Chinese Food Therapy
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and restore your health naturally with Chinese diet

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Sources
(1) ) http://www.ncbi.nlm.nih.gov/pubmed/19650632
(2) http://www.ncbi.nlm.nih.gov/pubmed/12424324
(3) http://www.ncbi.nlm.nih.gov/pubmed/15705230
(4) http://www.ncbi.nlm.nih.gov/pubmed/17173569
(5) http://www.ncbi.nlm.nih.gov/pubmed/16569044
(6) http://www.ncbi.nlm.nih.gov/pubmed/16569044
(7) http://www.ncbi.nlm.nih.gov/pubmed/17173569

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Chai Hu (Radix Bupleuri)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


              Chai Hu (Radix Bupleuri)


Chai Hu is also known as Bupleurum Root. The bitter, slightly cold herb has been used in TCM to cold and influenza, alternating chill and fever, malaria, irregular menses, prolapse of uterus and rectum, etc., as it regulates and clears Heat, drains the Liver, resolves depression and stagnation, raises Yang, etc by enhancing the functions of liver, gall bladder, pericardium, triple burner channels.

Ingredients
1. β-terpinene
2. imonene
3. β-fenchene
4. ulegone
5. Isoborneol
6. β-terpineol
7. α-copaene
8. Humulene
9. A-farnesene
10. Aromadendrene
11. Cis-caryophyllene
12. β-elemene,
13. Gamma-muurolene
14. Patchoulane
15. Pootkatone
16. Ledol
17. Etc.

Health Benefits
1. Lung cancer
Bupleuri radix, a traditional Chinese herb, has been widely used to treat liver diseases such as hepatitis and cirrhosis. In the evaluation of he acetone extract of Bupleurum scorzonerifolium (AE-BS) and its effect against lung cancer cells found that A549 cells treated with AE-BS showed typical morphologic features of apoptosis, and the percentage of apoptotic cells was approximately 38 % on day 1. In the TRAP assay, AE-BS-treated cells demonstrated significantly lower telomerase activity on day 3. This result indicates that the AE-BS could suppress the proliferation of lung cancer cells via inhibition of telomerase activity and activation of apoptosis, according to “Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity” by Cheng YL, Chang WL, Lee SC, Liu YG, Lin HC, Chen CJ, Yen CY, Yu DS, Lin SZ, Harn HJ.(1).

2. Liver fibrogenesis
In the investigation of traditional Chinese herb, Bupleurum scorzonerifolium and its inhibition of hepatic stellate cells (HSCs) activation in vitro, found that kaerophyllin in Bupleurum scorzonerifolium protected the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting HSC activation, possibly through upregulation of PPAR-γ expression, according to “Protective effects of kaerophyllin against liver fibrogenesis in rats” by Lee TF, Lin YL, Huang YT.(2).

3. Antioxidant effects
In the assessment of crude polysaccharide (CP) of Bupleurum scorzonerifolium Willd and its effect on immunopharmacologic functions found that the protective mechanisms of crude polysaccharide from the anti-UVB B. scorzonerifolium cell clone against UVB-induced photodamage occur by the inhibition of UVB-induced reactive oxygen species production, lipid peroxidation and DNA damage, according to “Crude polysaccharide from an anti-UVB cell clone of Bupleurum scorzonerifolium protect HaCaT cells against UVB-induced oxidative stress” by Dai J, Ma H, Fan J, Li Y, Wang J, Ni H, Xia G, Chen S(3).

4. Anti-aging
In the observation of the effect of isochaihulactone (also known as K8), a lignan compound of Bupleurum scorzonerifolium, on H(2)O(2)-induced cytotoxicity in neuronally differentiated PC12 cells (nPC12) found that isochaihulactone exerts potent anti-aging effects against D-gal in mice possibly via antioxidative mechanisms, according to “Isochaihulactone protects PC12 cell against H(2)O(2) induced oxidative stress and exerts the potent anti-aging effects in D-galactose aging mouse model” by YU SL, LIN SB, YU YL, CHIEN MH, SU KJ, LIN CJ, WAY TD, YIANG GT, LIN CC, CHAN DC, HARN HJ, CHEN YL.(4).

5. Immune system
In the analyzing isochaihulactone and chaihunaphthone, together with eleven known compounds isolated from the root of Bupleurum scorzonerifolium and testing for theirs Immunosuppressive effects found that In biological testing, eugenin and saikochromone potently inhibited CD28-costimulated activation of human peripheral blood T cells, according to “Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium” byChang WL, Chiu LW, Lai JH, Lin HC.(5).

6. Antidepressant
In the study of Xiaoyaosan, a famous Chinese prescription, including Chai Hu (Radix Bupleuri) and its anti depression effect, found that high dose xiaoyaosan was the most effective and amitriptyline equaled middle dose xiaoyaosan as shown by metabolomics strategy and behavior tests. Some common and characteristic metabolites on the anti-depression of xiaoyaosan and amitriptyline were obtained. The work showed metabolomics is a valuable tool in studying the efficacy and potential biomarkers of therapeutic effect of complex prescriptions, according to “Metabolomics study on the anti-depression effect of xiaoyaosan on rat model of chronic unpredictable mild stress” by Dai Y, Li Z, Xue L, Dou C, Zhou Y, Zhang L, Qin X.(6).

7. Etc.

Side Effects
1. Overdoses can be toxicity and cause headaches, dizziness, vomiting, tremors, gastroenteritis, etc.
2. Long term uses can be toxic to kidney
3. No not use the herb in children or if you are pregnant with out permission of related field specialists.
4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/12941440
(2) http://www.ncbi.nlm.nih.gov/pubmed/22103576
(3) http://www.ncbi.nlm.nih.gov/pubmed/21948115
(4) http://www.ncbi.nlm.nih.gov/pubmed/21042289
(5) http://www.ncbi.nlm.nih.gov/pubmed/14630002
(6) http://www.ncbi.nlm.nih.gov/pubmed/20079416







The Tasty Smoothie of Pineapple, Pomegranate and Green Tea for Prevention and Treatment of Pityriasis Lichenoides

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and Treatment of Pityriasis lichenoides
Yield: 2 serving (about 8 ounce each)
3/4 cups pineapple
3/4 cup pomegranate
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of fibromyalgia is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine to other organs in the body.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Pityriasis lichenoides is a skin condition of scaly rash in a small bumpy areas, with unknown causes. But someresearchers suggested that the diseases is a result of infection caused by a hypersensitivity reaction to infectious agents such as Epstein–Barr virus, adenovirus and Parvovirus B19

Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, such as pineapple(1), green tea(2) and  Pomegranate(3) for reduced risk and treatment for Pityriasis lichenoides. According to University of Siena, bromelain, a major chemical constituent in pineapple, exerted anti-inflammatory, immunomodulatory and/or anti-viral properties against Pityriasis lichenoides chronica (PLC) in a complete clinical recovery after treatment of 12 months(1).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to Dr. Reygaert WC, professor at the Oakland University William Beaumont School of Medicine Rochester, green tea, catechins (polyphenols) epidemiologically, expressed a potential for preventive and therapeutic purposes for treatmernt of diseases caused by microbial infection(2).
In the comparison of the effectiveness of pomegranate extract (POMx), pomegranate juice (POM juice) and green tea extract (GT), researchers found that The antibacterial properties of POMx and GT on the most common bacteria associated with the development and progression of skin diseases may offer a better preventative/therapeutic regimen with fewer side effects than those currently available(3).
According to Dr. Mo J and colleagues lead by the Prince of Songkla University, ellagic acid (EA) found in standardized pomegranate rind extracts (SPRE) exhibited the stability, in vitro drug release, and skin penetration/retention against dermal diseases(4).
Furthermore, in comparison of the anti-inflammatory and analgesic activities of standardized pomegranate rind extract with its marker compound ellagic acid in vivo, the Prince of Songkla University suggested, SPRE was more active as an anti-inflammatory agent than EA through it inhibited the leukocyte infiltration and modulated the pro-inflammatory cytokines IL-β and TNF-α(5).

Taking altogether, intake of combination of pineapple, orange and banana exhibited anti infection and anti inflammatory activities may be a potential ingredients with therapeutic values for prevention and treatment of Pityriasis lichenoides. 

People who are at increased risk of People who are at increased risk of Pityriasis lichenoides due to family history, weaken immunity, ,....should drink at least one cup daily and people with Pityriasis lichenoides should drink the smoothie as much as they can, depending to digestive and liver toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Role of bromelain in the treatment of patients with pityriasis lichenoides chronica by Massimiliano R1, Pietro R, Paolo S, Sara P, Michele F.(PubMed)
(2) The antimicrobial possibilities of green tea by Reygaert WC1.(PubMed)
(3) Antimicrobial Activity of Pomegranate and Green Tea Extract on Propionibacterium Acnes, Propionibacterium Granulosum, Staphylococcus Aureus and Staphylococcus Epidermidis by Li Z, Summanen PH, Downes J, Corbett K, Komoriya T, Henning SM, Kim J, Finegold SM.(PubMed)
(4) Physicochemical properties, in vitro release and skin permeation studies of a topical formulation of standardizedpomegranate rind extract by Mo J1, Kaewnopparat N2, Songkro S2, Panichayupakaranant P3, Reanmongkol W1.(PubMed)
(5) Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo by Mo J1, Panichayupakaranant P, Kaewnopparat N, Nitiruangjaras A, Reanmongkol W.(PubMed)

Most Common Diseases of Men of 50Plus - Prostate Health - Causes of Enlarged Prostate

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Starting at age 40, the levels of the by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT triggering prostate enlargement and other problems. Therefore in order to prevent the symptoms of enlarged prostate is to naturally impend the conversion of testosterone to DHT. Unfortunately, aging is not the only cause of enlarged prostate. In this article, we will discuss other causes of prostate enlargement.

1. Genetics
Genetics may also play a role in enlarged prostate since study shows that prostate cancer and enlarged prostates can be inherited from generation to generation.

2. Hormone imbalance
The outward appearance of a typical middle-aged person shows increased abdominal fat and shrinkage of muscle mass, which is the main factor causing hormone imbalance. Hormone imbalance is also caused by depression, stress, and anxiety that are the most common psychological complications of hormone imbalance.

3. Cell-growth factor
For whatever reason, some people have implicated in enlarged prostate that is a growth factor.

4. Mineral deficiency
Our prostate contains high amounts of zinc to function normally. Zinc deficiency causes the prostate to enlarge. This may be due to aging or uncontrolled diet with excessive alcohol drinking.

5. Obesity
Study shows that uncontrolled diet that is high in saturated and trans fats are the main cause of hormone imbalance that results in prostate enlargement. Researchers suggest that excess calorie consumption could somehow directly stimulate prostate enlargement because the excess body fat that accumulates causes an imbalance of hormone levels.

6. Testosterone
Testosterone deficiency may be caused by high amounts of the by-product prolactin of testosterone of men in the body that stimulates even higher productions of the enzyme 5-alpha reductase resulting in a high amount of the conversion of testosterone to gihydro-testosterones DHT thus triggering prostate enlargement. Excess estrogen seems to be the culprit in prostate enlargement that leads to the pathology and favors the development of prostate cancer.Chinese Food Therapy
The Best Way to prevent, treat your disease, including Erectile Dysfunction
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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The Obesity's Weight Loss Recipes: Sauerkraut salad

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The best weigh loss and tasty recipe attributed to Company's Coming Salads by Jean Parè


And there the similarly ends. Even if you don't like sauerkraut, you will love this tasty salad. very attractive.
Canned sauerkraut, drained 28oz. (796 ml)
Diced celery 1 cup (250ml)
Diced green pepper 1 cup (250ml)
Diced onion 1/4 cup (50ml)
Small jar pimentos, chopped 1
Granulated sugar 3/4 cup (175ml)
Salt 1/2 tsp. (2 ml)
Pepper 1/8 tsp. (0.5 ml)
Celery seed 1 tsp. (5ml)
Vinegar 3 tbsp. (50ml)
Rinse sauerkraut. Squeeze dry and chop. Put into large bowl.
Add rest of ingredients in order. Mix well. Let stand covered in refrigerator overnight before serving. Serve 10.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Insulin resistance improvement and/or anti metabolic syndrome herbal Green Tea

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).


 The prevention and management In Herbal Medicine

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).

The Insulin resistance improvement and/or anti metabolic syndrome herbs:Green Tea(1065)



Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world(1065).

Ingredients
1. Epigallocatechin gallate
2. Flavonoids
3. Tannins
4. Caffeine
5. Polyphenols
6. Boheic acid
7. Theophylline
8. Theobromine
9. Anthocyanins
10. Gallic acid
11. Etc.

Epidemiological studies, linking green tea in reduced risk of prevented the development of insulin resistance(1066)(1067) and metabolic sundrome such as obesity(1068)(1069)(1073), hypertension(1070)(1071) hypercholesterolemia and hyperglycemia(1072)(1073), diabetes(1074)(1075)... have produced some statistic results.
In inslunin resistances, epigallocatechin gallate (EGCG), the major chemical constituents of green tea effectively modulate of insulin productionb throughinhibited insulin-stimulated glucose uptake(1076)(1078)(1077) via some mechnisms, including attenuated inflammatory cytokine levels(1076), inhibition of the GLUT4(the insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac).) translocation(1077), AMPK pathways(an enzyme that plays a role in cellular energy homeostasis)(1078)....
In metabolic synfrome, green tea extract, polyphenol epigallocatechin gallatesignificantly controled abnormalities linked to metabolic syndrome (MS)(1079)(1080)(1083)(1084)(1085) through influence the maintenance of weight loss(1079)(1082)(1084), high-density lipoprotein-cholesterol(1079), triglycerides(1079), and glucose concentrations(1079)(1080), counteracted endothelial dysfunction(1080)(1081) and ameliorated metabolic insulin resistance(1080) in skeletal muscle and liver(1080).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods LibraryEat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)
(1065) Popular Herbs - Green Teaby Kyle J. Norton
(1066) The Effect of Green Tea versus Sour Tea on Insulin Resistance, Lipids Profiles and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial by Mozaffari-Khosravi H1, Ahadi Z1, Fallah Tafti M2.(PubMed)
(1067) Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial by Liu CY1, Huang CJ2, Huang LH3, Chen IJ1, Chiu JP1, Hsu CH1.(PubMed)
(1068) Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia by Ahmad RS1, Butt MS2, Sultan MT3, Mushtaq Z4, Ahmad S5, Dewanjee S6, De Feo V7, Zia-Ul-Haq M8.(PubMed)
(1069) Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea by Diepvens K1, Westerterp KR, Westerterp-Plantenga MS.(PubMed)
(1070) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)
(1071) Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts by Antonello M1, Montemurro D, Bolognesi M, Di Pascoli M, Piva A, Grego F, Sticchi D, Giuliani L, Garbisa S, Rossi GP.(PubMed)
(1072) The role of green tea extract and powder in mitigating metabolic syndromes with special reference to h)yperglycemia and hypercholesterolemia by Yousaf S1, Butt MS, Suleria HA, Iqbal MJ.(PubMed)
(1073) Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia by Ahmad RS1, Butt MS2, Sultan MT3, Mushtaq Z4, Ahmad S5, Dewanjee S6, De Feo V7, Zia-Ul-Haq M8.(PubMed)
(1074) The effect of Ginkgo biloba and Camellia sinensis extracts on psychological state and glycemic control in patients with type 2 diabetes mellitus by Lasaite L, Spadiene A, Savickiene N, Skesters A, Silova A.(PubMed)
(1075) The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults by Iso H1, Date C, Wakai K, Fukui M, Tamakoshi A; JACC Study Group.(PubMed)
(1076) Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced Toll-like receptor 4 (TLR4) activity via 67 kDa laminin receptor (67LR) in 3T3-L1 adipocytes by Bao S1, Cao Y1, Zhou H1, Sun X1, Shan Z1, Teng W1.(PubMed)
(1077) Green tea (-)-epigallocatechin gallate suppresses IGF-I and IGF-II stimulation of 3T3-L1 adipocyte glucose uptake via the glucose transporter 4, but not glucose transporter 1 pathway by Ku HC1, Tsuei YW2, Kao CC2, Weng JT3, Shih LJ3, Chang HH1, Liu CW1, Tsai SW4, Kuo YC5, Kao YH6.(PubMed)
(1078) Green tea epigallocatechin gallate inhibits insulin stimulation of adipocyte glucose uptake via the 67-kilodalton laminin receptor and AMP-activated protein kinase pathways by Hsieh CF1, Tsuei YW, Liu CW, Kao CC, Shih LJ, Ho LT, Wu LY, Wu CP, Tsai PH, Chang HH, Ku HC, Kao YH.(PubMed)
(1079) Effects of Rye Bread Enriched with Green Tea Extract on Weight Maintenance and the Characteristics of Metabolic Syndrome Following Weight Loss: A Pilot Study by Bajerska J1, Mildner-Szkudlarz S, Walkowiak J.(PubMed)
(1080) Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate by Keske MA, Ng HL, Premilovac D, Rattigan S, Kim JA, Munir K, Yang P, Quon MJ1.(PubMed)
(1081) Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction by Jang HJ1, Ridgeway SD, Kim JA.(PubMed)
(1082) Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial by Mielgo-Ayuso J1, Barrenechea L2, Alcorta P3, Larrarte E4, Margareto J4, Labayen I1.(PubMed)
(1083) Polyphenols: planting the seeds of treatment for the metabolic syndrome by Cherniack EP1.(PubMed)
(1084) Weight control and prevention of metabolic syndrome by green tea by Sae-tan S1, Grove KA, Lambert JD.(PubMed)
(1085) The potential role of green tea catechins in the prevention of the metabolicsyndrome - a review by Thielecke F1, Boschmann M.(PubMed)
(1086) Popular Herbs -Cinnamonby Kyle J. Norton

The Obesity' Research and Studies of obesity paradox in chronic disease: facts and numbers

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of  obesity paradox in chronic disease: facts and numbers

In the investigation of Whether this is justified depends upon the state of health and should be judged individually. For patients with established chronic disease, there is sufficient evidence to support the benefits of large body size, i.e., the obesity paradox, found that the uniform finding is shared over a variety of cardiovascular, pulmonary, and renal diseases and is counterintuitive to the current concepts on ideal body weight. The scientific community has to increase the awareness about differences for optimal body size in health and disease. Simultaneously, clinicians have to be aware about body weight dynamics implications and should interpret the changes in the context of an underlying disease in order to implement the best available management.(1)


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(1) "The obesity paradox in chronic disease: facts and numbers" by Lainscak M,von Haehling S, Doehner W, Anker SD.