Medical Advisor Journals

Sunday, July 10, 2016

Phytochemicals in Foods - The Effects of Piceatannol

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Piceatannol

Piceatannol is a phytochemical in the class of Stilbenoids, found abundantly in grapes, etc.

Health Benefits
1. Anti cancers
In the determination of the apoptotic effects of piceatannol and myricetin, naturally occurring polyphenols in red wine, alone or in combination, in two human cell lines: HL-60 (leukemia) and HepG2 (hepatoma), found that on the signaling pathways responsible for induction of HO-1 expression.found that piceatannol or myricetin alone induced apoptotic cell death in a concentration- and time-dependent manners in HL-60 cells. Furthermore, in combined treatment the percentage of apoptotic HL-60 cells was significantly higher. Nevertheless, the percentage of TUNEL positive HepG2 cells only was significant after piceatannol treatment and in combined treatment was even lower than in cells treated with piceatannol alone, according to "Selective apoptotic effects of piceatannol and myricetin in human cancer cells" by Morales P, Haza AI.(1)

2. Breast cancer
found that PIC inhibited migration and anchorage-independent growth of human mammary epithelial cells (MCF-10A) treated with the prototypic tumor promoter, 12-O-tetradecanoylphorbol-13-aceate (TPA). PIC treatment suppressed the TPA-induced activation of NF-kappaB and expression of cyclooxygenase-2 (COX-2) in MCF-10A cells. We speculate that an electrophilic quinone formed as a consequence of oxidation of PIC bearing the catechol moiety may directly interact with critical cysteine thiols of IKKbeta, thereby inhibiting its catalytic activity "Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target" by Son PS, Park SA, Na HK, Jue DM, Kim S, Surh YJ.(2)

3. Anti-inflammatory activities and cardioprotective effect
In the investigation of the modulation of inflammation by resveratrol and its metabolites by determining the expression and release of chemokine, eotaxin-1, in cultured human pulmonary artery endothelial cells, found that piceatannol showed potency similar to resveratrol. We propose that control of eotaxin-1 expression and release by proinflammatory cytokines in HPAEC may be considered as an in vitro model for screening and discovering polyphenols with anti-inflammatory activities and cardioprotective potentials, according to "Control of eotaxin-1 expression and release by resveratrol and its metabolites in culture human pulmonary artery endothelial cells" by Yang CJ, Lin CY, Hsieh TC, Olson SC, Wu JM.(3)

4. Alzheimer's disease
In the demonstration of the presence of autoantibodies to ecto-F1-ATPase (ASabs) in sera and cerebrospinal fluids from patients with Alzheimer's disease (AD), found that ASabs, unlike irrelevant antibodies, can increase cellular uptake of HDL, a risk factor for the development of AD, via a mechanism involving the prototypical function of ecto-F1-ATPase: the generation of ADP due to the hydrolysis of ATP. Piceatannol, a specific inhibitor ecto-F1-ATPase, completely hindered these effects. We hypothesize that ASabs could exert a pathogenetic role in AD, according to "Anti-ATP synthase autoantibodies from patients with Alzheimer's disease reduce extracellular HDL level" by Vacirca D, Barbati C, Scazzocchio B, Masella R, Rosano G, Malorni W, Ortona E.(4)

5. Prostate cancer
In the determination of whether piceatannol inhibits the lung metastasis of prostate cancer cells, MAT-Ly-Lu (MLL) rat prostate cancer cells expressing luciferase were injected into the tail veins of male nude mice, found that Piceatannol increased the protein levels of tissue inhibitor of metalloproteinase-2 in a concentration-dependent fashion. Additionally, piceatannol inhibited the phosphorylation of signal transducer and activator of transcription (STAT) 3. Furthermore, piceatannoleffected reductions in both basal and EGF-induced interleukin (IL)-6 secretion. An IL-6 neutralizing antibody inhibited EGF-induced STAT3 phosphorylation and EGF-stimulated migration of DU145 cells. Interleukin-6 treatment was also shown to enhance the secretion of uPA and VEGF, STAT3 phosphorylation and the migration of DU145 cells; these increases were suppressed by piceatannol. These results demonstrate that the inhibition of IL-6/STAT3 signaling may constitute a mechanism by which piceatannol regulates the expression of proteins involved in regulating the migration and invasion of DU145 cells, according to "Piceatannolinhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling" by Kwon GT, Jung JI, Song HR, Woo EY, Jun JG, Kim JK, Her S, Park JH.(5)

6. Antiallergic and radical scavenging activities
In the assessment of the methanolic extract of the whole plant of Cyperus longus originating in Egypt and its antiallergic effect on ear passive cutaneous anaphylaxis reactions in mice,
found that Among the isolates, longusol B (IC(50)=96 µM), luteolin (3.0 µM), resveratrol (17 µM), piceatannol (24 µM), and cassigarols E (84 µM) and G (84 µM) were found to inhibit the release of β-hexosaminidase, as a marker of antigen-induced degranulations, in rat basophilic leukemia (RBL-2H3) cells, accoridng to "Structures of novel norstilbene dimer, longusone A, and three new stilbene dimers, longusols A, B, and C, with antiallergic and radical scavenging activities from Egyptian natural medicine Cyperus longus" by Morikawa T, Xu F, Matsuda H, Yoshikawa M.(6)

7. Anti aging
In the review of the cellular senescence, characterized by cellular hypertrophy: cell growth in the absence of cell division, indicated that the genes that regulate this process can be activated or inactivated by numerous plant polyphenols such as resveratrol, quercetin, butein, fistein, piceatannol, curcumin. Many of these substances have been shown to lengthen the lifespan of invertebrates. Many of these compounds have other potential beneficial effects on lifespan as antiatherogenic or antineoplastic agents, according to "The potential influence of plant polyphenols on the aging process" by Cherniack EP.(7)

8. Melanogenesis and collagen synthesis
In the evaluation of The effect of passion fruit, the fruit of Passiflora edulis , on melanin inhibition and collagen synthesis, using cultured human melanoma and fibroblast cells, found that treatment of melanoma cells with PF-S led to inhibition of melanogenesis. In addition, the production of total soluble collagen was elevated in dermal fibroblast cells cultured in the presence of PF-S. PF-R and PF-P did not yield these effects. Furthermore, the removal of polyphenols from PF-S led to the abolishment of the effects described above. We discovered thatpiceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is present in passion fruit seeds in large amounts and that this compound is the major component responsible for the PF-S effects observed on melanogenesis and collagen synthesis, according to "Extract of Passion Fruit ( Passiflora edulis ) Seed Containing High Amounts of Piceatannol Inhibits Melanogenesis and Promotes Collagen Synthesis" by Matsui Y, Sugiyama K, Kamei M, Takahashi T, Suzuki T, Katagata Y, Ito T.(8)

9. Colitis
In the investigation of the possible protective effects of resveratrol and piceatannolagainst dextran sulfate sodium (DSS)-induced inflammation in mouse colonic mucosa, found that oral administration of resveratrol or piceatannol (10 mg/kg body weight each) for 7 constitutive days attenuated the DSS-induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappaB, STAT3, and ERK, according to "Resveratrol and piceatannol inhibit iNOS expression and NF-kappaB activation in dextran sulfate sodium-induced mouse colitis" by Youn J, Lee JS, Na HK, Kundu JK, Surh YJ.(9)

10. Etc.

General Health: Anemia - The Preventive Supplements

Women Health: Menstrual Disorder - Dysmenorrhea - Symptoms of Dampness In TCM Perspective

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Dysmenorrhea

Dysmenorrhea (painful menstruation) is defined as a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of over production of certain hormones in the prostaglandins family. In traditional Chinese medicine, dysmenorrhea is defined as a pain in the lower abdomen, appearing with menstrual cycle that can spread over to the whole abdomen and lumbosacral region, depending to diagnosis.

Girls in South East Asia have learnt in their early women life from grand mother wisdom, that they do not engage in any activity, distorting their regular period. Irregular period should be treated immediately, otherwise, it may cause wide range of women diseases, such as infertility, according to Traditional Chinese medicine.

The Symptoms

Dampness in traditional Chinese medicine is defined as high humidity inside the body. Symptoms can include
1. A feeling of heaviness
Since spleen is important in digesting and absorbing water, dampness causing abnormal function of spleen in regulating the water metabolism in the body, thus impairing spleen yang that leads to a feeling of heaviness body.

2. Swelling or water retention
High humidity may be caused kidney yin deficiency as resulting of kidney no longer function in regulating the fluid and distribute the fluids according to the needs of each organs, caused by stagnation of qi, leading to water retention and swelling in some parts of the body.

3. Abdomen cramps and pain
As dampness accumulated in the body, it has a tendency to move downward to the legs and settles into lower abdomen, causing abdomen discomfort, cramps and pains.

4. Phlegm discharge
It is caused by stagnation of liver qi which helps spleen and kidney in water metabolism, leading to congealed water metabolism in the body, resulting in phlegm discharge.

5. Loose bowels
Over consumption of cold and raw foods causes food stagnation in the digestive system that impairs spleen yang, a organ in regulating the distribution of water in our body, leading to interior cold, causing loose bowels for some women with dysmenorrhrea.
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

The Best Weight Loss and Healthy Recipe - Loopy O Booster

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Best Weight Loss and Healthy Recipe - Loopy O Booster
Diabetic recipe Contributed by diabetic cooking "Great tasting recipe for the entire Family" by Jean Pare, published by Company coming.

This fruity little bar will carry you through when you are feeling slow on the go
Margarine 2tbsp. 30ml
White corn syrup 1/3 cup 75 ml
Package of fruit-flavoured gelatin (jelly powder) you favorite (not sugar-free) 3oz. 85g
"O" shaped fruity cereal (such as fruit loops) 4 cups 1L
Melt margarine in a large saucepan on medium. Stir I=in corn syrup and jelly powder. Heat and stir until boiling and jelly powder is dissolved. Remove from heat
Quickly stir in cereal to cool. Mixture will be very sticky, so work fast. Press firmly into greased foil-lined 8x8 inch (20x20 cm) square pan. Chill just until set. Cup into 18 bars. Wrap individual bar in plastic wrap. Freeze. Make 18 bars.
1 bar; 74 calories; 1.4g total fat (.3 g sat., 0 mg cholesterol); 60 mg sodium; 1g protein; 15 g carbohydrate; trace dietary fiber
Choice: 1 Other choice
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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The Smoothie of Olive, Sweet Potato and Grape Juice for Prevention of Conorenal syndrome's Complication of Chronic Kidney Disease in Progression to Kidney failure

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Conorenal syndrome, also known as Mainzer-Saldino syndrome or Saldino-Mainzer disease is a medical condition of diseases involved kidney, skeletal system and eye.

In order to reduce the complications of kidney disease in Conorenal syndrome, one must try to prevent the develop of chronic kidney disease and progression to kidney failure.

1. Prevent the development of Chronic Kidney Disease

The smoothie for prevention and treatment of Kidney disease in Conorenal syndrome

Yield: 2 servings (about 8 ounces each)

1/2 cup olive

1 cup cooked sweet potato

1 cup organic grape juice

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of Chronic Kidney disease (induced Cardiovascular disease) inConorenal syndrome.

Chronic Kidney Diseases(CKD) Conorenal syndrome is a progressive loss of kidney function over period longer than 3 months through different stages, deepening to the GFR (Glomerular Filtration Rate). According to the Tri-Service General Hospital, Excessive oxidative stress increased oxidative nucleicacid damage and exaggerated the development of complication of Chronic Kidney Diseases(1).

The Anti-Odxidant Therapy in Chronic Renal Insufficiency (ATIC) study suggested, combination of pravastatin, vitamin E, and homocysteine treatment in 18 months together with hypertension controlled effectively attenuated expression of Chronic Kidney Diseases(CKD) through reduced oxidative stress against renal function(2).Vitamin E-coated membranes (VECMs) consist of a multilayer membrane with liposoluble vitamin E, used in dialysis significantly improved Hb levels and lower rHuEpo requirements in chronic HD patients(3).Dr. Rashid Khan M and colleagues insisted, vitamin E significantly reduced dyslipidemia and inhibited the development of CRD caused by atherogenic factors after six weeks. particular in hypolipidemic and nephroprotective activity against free radical-related diseases(4).

N-3 fatty acids found abundantly in olive may also contribute to the potential benefits of dietary fat

modification in CKD patients, according to the Karolinska Institutet(5).

Dr. Lee SM and Dr. An WS., professors at the Seoul National University Hospital, insisted, intake of Omega 3 fatty acid exhibited cardioprotective effects in chronic kidney disease, the main cause of death, through attenuated inflammation, dyslipidemia, malnutrition, atherosclerosis, and vascular calcification(6).

Dr. Friedman AN said, " Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA), which are obtained primarily from dietary sources such as coldwater fish, have diverse and potent mediating effects on the immune, inflammatory, and metabolic pathways, signal transduction, and cell membrane physiology" and "In the meantime, the current American Heart Association n-3 PUFA intake guidelines can be applied to CKD patients"(7).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry, may also benefit in attenuated complications and treatment of Chronic Kidney Diseases(CKD), through its inflammation and oxidative stress modulation (8).

According to the joint study led by the The Catholic University of Korea, Bucheon, resveratrol expressed renoprotective effects by activating NRF2 signaling against against oxidative or electrophilic stress(9). Furthermore by suppressing the pro inflammatory cytokines, consumption of white wine and olive oil, significantly reduced plasma markers of chronic inflammation in CKD patients.

The effectiveness of Cooked Sweet Potato, Olive and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Chronic Kidney disease in Conorenal syndrome with little or no adverse effects.

People who are at high risk of Kidney disease in Conorenal syndrome should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.

2. Prevent the Progression to Kidney failure in Conorenal syndrome

Yield: 2 servings (about 8 ounces each)

1/2 cup tomato

1 cup blueberry

1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Acute kidney failure in Conorenal syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Acute kidney failure is the rapid (less than 2 days) loss of your kidney function in removed waste and balanced fluids and electrolytes in your body. According to the Vrije Universiteit Brussel and Academic Hospital of the Vrije Universiteit Brussel, the progression of acute kidney failure also altered antioxidant defense in mouse adriamycin model(10), due to increased oxidative stress(11).

Recent studies back by well known institutions proposed, Green tea, Tomato and Bluebberry may be the next generation of natural ingredients for prevention and treatment of Acute kidney failure in Conorenal syndrome.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the study led by the Kyoto University Graduate School of Medicine, epigallocatechin-3-gallate (EGCG) is a major component of the polyphenolic fraction of green tea, ameliorated (Acute kidney failure) AKI in a cardiopulmonary bypass (CPB) model of diabetic rats through antioxidative properties(12).

In a small piglet model of extracorporeal circulation, the phytochemical also exhibited reno protective effects through its antioxidant, antiapoptotic and NO-scavenging properties(13).

Dr. Nasri H and professors led by the Isfahan University of Medical Sciences said," beneficial property of green tea, against renal toxicity of contrast media was observed. Green tea extract is an inexpensive, nontoxic, and effective treatment modality in individuals with a risk for acute kidney injury of contrast media"(14).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly grape and blueberry also
exhibited anti acute kidney diseases by prevented endotoxin-induced disruption of endothelial cell permeability and inhibited inflammation of kidney tissue(15).

According to the University of Arkansas for Medical Sciences, resveratrol reduced the mortality rate of patients who develop acute kidney injury during sepsis through improvement in capillary perfusion and increased renal blood flow and the glomerular filtration rate without raising systemic pressure(16).

Dr. Kim DH and colleagues at the Chonbuk National University said, " Resveratrol expressed modulation of p53 (antigen), by SIRT1 (in several separated cellular functions), could be a possible target to attenuate cisplatin-induced kidney injury"(17).

Lycopene found abundantly in tomato, a derivative of carotenoids also expressed nephroprotective effect against cisplatin-induced acute kidney injury in rats, according to the Firat University(18).

The Federal University of Santa Maria study, proposed " lycopene could plays a beneficial role in acute renal failure against HgCl(2) toxicity by preventing lipid peroxidation and changes in the activity of delta-aminolevulinate dehydratase and antioxidant enzymes"(19).

Dr. Ateşşahin A and colleagues in the investigation of the possible protective role of antioxidant treatment with lycopene on cyclosporine A-induced nephrotoxicity using biochemical and histopatological approaches found that natural antioxidant lycopene might have protective effect against cyclosporine-induced nephrotoxicity and oxidative stress in rat(20).

The effectiveness of Green tea, Tomato and Blueberry may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Acute kidney failure in Conorenal syndromewith little or no adverse effects.

People who are at high risk of Acute kidney failure in Conorenal syndrome due to genetic mutation should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis

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Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease by Sung CC1, Hsu YC, Chen CC, Lin YF, Wu CC.(PubMed)
(2) Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study by Nanayakkara PW1, van Guldener C, ter Wee PM, Scheffer PG, van Ittersum FJ, Twisk JW, Teerlink T, van Dorp W, Stehouwer CD.(PubMed)
(3) Effect of vitamin E-coated dialysis membranes on anemia in patients with chronic kidney disease: an Italian multicenter study by Cruz DN1, De Cal M, Garzotto F, Brendolan A, Nalesso D, Corradi V, Ronco C.(PubMed)
(4) Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats by Rashid Khan M1, Ahsan H, Siddiqui S, Siddiqui WA.(PubMed)
(5) Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond by Huang X1, Lindholm B, Stenvinkel P, Carrero JJ.(PubMed)
(6) Cardioprotective effects of ω -3 PUFAs in chronic kidney disease. by Lee SM1, An WS.(PubMed)
(7) Omega-3 fatty acid supplementation in advanced kidney disease by Friedman AN1.(PubMed)
(8) Resveratrol: why is it a promising therapy for chronic kidney disease patients?by Saldanha JF1, Leal Vde O2, Stenvinkel P3, Carraro-Eduardo JC4, Mafra D1.(PubMed)
(9) Effect of redox modulating NRF2 activators on chronic kidney disease.by Choi BH1, Kang KS2, Kwak MK3.(PubMed)

(10) Altered antioxidant defense in a mouse adriamycin model of glomerulosclerosis by Deman A1, Ceyssens B, Pauwels M, Zhang J, Houte KV, Verbeelen D, Van den Branden C.(PubMed)

(11) Increased oxidative stress in the mouse adriamycin model of glomerulosclerosis is accompanied by deposition of ferric iron and altered GGT activity in renal cortex by Ceyssens B1, Pauwels M, Meulemans B, Verbeelen D, Van den Branden C.(PubMed)

(12) Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass by Funamoto M1, Masumoto H1, Takaori K2, Taki T1, Setozaki S1, Yamazaki K1, Minakata K1, Ikeda T3, Hyon SH4, Sakata R1.(PubMed)

(13) Reno-protective effects of epigallocatechingallate in a small piglet model of extracorporeal circulation by Twal M1, Kiefer P, Salameh A, Schnabel J, Ossmann S, von Salisch S, Krämer K, Sobiraj A, Kostelka M, Mohr FW, Dhein S.(PubMed)

(14) A biochemical study on ameliorative effect of green tea (Camellia sinensis) extract against contrast media induced acute kidney injury by Nasri H1, Ahmadi A2, Baradaran A3, Nasri P4, Hajian S4, Pour-Arian A4, Kohi G5, Rafieian-Kopaei M5.(PubMed)

(15) Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages by Chen L1, Yang S, Zumbrun EE, Guan H, Nagarkatti PS, Nagarkatti M.(PubMed)

(16) Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury by Holthoff JH1, Wang Z, Seely KA, Gokden N, Mayeux PR.(PubMed)

(17) SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53 by Kim DH1, Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Han MK, Lee SY, Ramkumar KM, Sung MJ, Kim W.(PubMed)

(18) Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation by Erman F1, Tuzcu M, Orhan C, Sahin N, Sahin K.(PubMed)

(19) Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats by Augusti PR1, Conterato GM, Somacal S, Einsfeld L, Ramos AT, Hosomi FY, Graça DL, Emanuelli T.(PubMed)

(20) Lycopene, a carotenoid, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rats by Ateşşahin A1, Ceribaşi AO, Yilmaz S.(PubMed)

The Obesity' Research and Studies of The Mediterranean diet: is it cardioprotective?

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of The Mediterranean diet: is it cardioprotective?

Researchers at the University of California, San Francisco, San Francisco that increasing scientific evidence suggests that the traditional Mediterranean diet may reduce the risk of cardiovascular disease. The cardiovascular benefits of this whole-diet approach may outweigh those of typically prescribed low-fat diets. The burden of coronary heart disease is enormous, and nutritional approaches that optimize cardiovascular health are essential(1).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

(1) " The Mediterranean diet: is it cardioprotective?" by Bautista MC, Engler MM.

Most Common Diseases of 50plus: Disease of CNS -: Alzheimer's Disease(AD) (The Article) Prevention - What to Avoid

The Prevention - What to Avoid

Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal. In this article, we will discuss what to avoid so you can cut the risk of developingAlzheimer's disease.

1. Limit intake of processed sugar
Study shows that intake of high amounts of processed sugar over a long period causes worse learning and memory retention and in the brain and increasing amyloid plaque deposits. Sugar beverage causes the increasing blood levels of beta-amyloid, a sticky protein substance that builds up in the brain resulting inAlzheimer's disease.

2. Limit intake of salt
Sodium is crucial for maintaining the health of every cell in the human system. Excessive salt consumption contributes to the development of high blood pressure heart disease and stroke causing depletion of oxygen in the bloodstream resulting in plague and tangle building up in certain regions of the brain.

3. Limit the use of aluminum cook ware
Overheating aluminum cookware will cause a chemical reaction and aluminum leaking into your food resulting in heavy mental accumulated in certain regions in your brain increasing the risk of Alzheimer' s disease.

4. Replace farm fish with wild fish
Farm fish grows in crown areas, contain high amounts of mercury and lead that are not only harmful to your body but also causes the accumulation of such chemicals in your brain resulting in a increased the risk of Alzheimer's disease.

5. Use purifier in your tab water
In order to avoid the intake of heavy metal through water drinking, the best solution is to purify your tab water before drinking or drinking only boiled water.

6. Avoid foods that are stripped of vital nutrition
Food that contains caffeine, artificial additive and trans fat will strip away the vital nutritions resulting in nutritional deficiency causing many health problems including malnutrition of brain cells.

7. Limit intake of alcohol
Alcohol damage of the cerebral cortex and hippocampus region of the brain results in loss of memory and communication difficulty.

8. Stop smoking
Smoking depletes the oxygen level in our bloodstream and also causes the hardening, thickening of arteries and promoting calcium sticking to the arterial wall resulting in less nutrition to nourish our brain cells as well as causing rupture of the brain vessels.