Medical Advisor Journals

Tuesday, July 12, 2016

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: TCM recommended Foods for Spleen Yang deficiency - Royal jelly

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

Management and Treatment according to Traditional Chinese Medicine Perspective

While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.

Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Spleen yang deficiency

Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....

Foods for Spleen yang deficiency

Spleen yang deficiency can be managed and treated in part with a diet of fresh and cooked warming foods.

1. Royal jelly(See kidney yang deficiency for more information)
Royal jelly is produced by the worker bees and fed to bee larves for 3 days to stimulate healthy and rapid growth and life for the queen to ensure the endless production of eggs, used in traditional Chinese medicine to treat malnutrition in children(1653), cognitive decline(1654) and sarcopenia due to ageing(1655), leukopenia(1656), liver diseases(1657)(1658)(1659), ulcer(1660)(1661), bronchial asthma(1662)(1663), diabetes(1664)(1665), high blood pressure(1666)(1667), cognitive impairment(1668), functional uterine abnormality(1669) through its estrogenic activitie(1670), irregular menses(1571) and functional infertility(1672) by enhancing function of spleen, liver and kidney channels(1653).

Chemical constituent(1653)
1. Inositol
2. 6-Biopterin
3. Flavin adenine dinucleotide
4. Flavin mononucleotide
5. Kynurenine
6. Albumin
7. β and γ globulin
8. Insoluble protein
9. Acetylcholine
10. Stearin
11. Phospholipid
12. Adenine nucleotides
13. Arginine
14. Aspartic acid
15. Glutamic acid
16. Lysine
17. Proline
18. β-alanine
18. Etc.

Epidemiological studies suggested that royal jelly also displays certain metabolic syndrome effects, such as glucose tolerance(1673), anti insulin resistance(1677)(1679), anti hypertension(1677), anti-hypercholesterolemic(1654)(1675) and anti-hyperglycemic(1654)(1678), induced weight loss(1676) and reduced risk of symptoms of fatigue( 1682), depression(1683) and anxiety(1683) and complication, such as diabetes(1678), breast cancer(1684)(1685) through anti-inflammatory(1654), anti-oxidative(1654) and immune defense(1674) activities.
According to joint study by Urmia University and Kermanshah University of Medical Sciences, royal jelly also improved reproductive parameters(1680)(1681) such as testicular weight, sperm count, viability, motility, deformity, DNA integrity, chromatin quality, serum testosterone and testicular tissue MDA levels in male diabetic rats(1680).

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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1653) Royal bee jelly(Complementary and Alternative Healing University)
(1654) Long-term administration of Greek Royal Jelly improves spatial memory and influences the concentration of brain neurotransmitters in naturally aged Wistar male rats by Pyrzanowska J1, Piechal A1, Blecharz-Klin K1, Joniec-Maciejak I1, Graikou K2, Chinou I2, Widy-Tyszkiewicz E3.(PubMed)
(1655) Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro by Niu K1, Guo H, Guo Y, Ebihara S, Asada M, Ohrui T, Furukawa K, Ichinose M, Yanai K, Kudo Y, Arai H, Okazaki T, Nagatomi R.(PubMed)
(1656) In-depth phosphoproteomic analysis of royal jelly derived from western and eastern honeybee species by Han B1, Fang Y, Feng M, Lu X, Huo X, Meng L, Wu B, Li J.(PubMed)
(1657) Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin by Karadeniz A1, Simsek N, Karakus E, Yildirim S, Kara A, Can I, Kisa F, Emre H, Turkeli M.(PubMed)
(1658) Serum and liver tissue bio-element levels, and antioxidant enzyme activities in carbon tetrachloride-induced hepatotoxicity: protective effects of royal jelly by Cemek M1, Yılmaz F, Büyükokuroğlu ME, Büyükben A, Aymelek F, Ayaz A.(PubMed)
(1659) The effects of royal jelly on liver damage induced by paracetamol in mice by Kanbur M1, Eraslan G, Beyaz L, Silici S, Liman BC, Altinordulu S, Atasever A.(PubMed)
(1660) The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial by Siavash M1, Shokri S, Haghighi S, Shahtalebi MA, Farajzadehgan Z.(PubMed)
(1661) [Influence of honey, royal jelly and propolis on accelerating acetate healing of experimental gastric ulcers in rats].[Article in Russian] by Belostotskiĭ NI, Kas'ianenko VI, Dubtsova EA, Lazebnik LB.(PubMed)
(1662) Complementary and alternative medicine in children with asthma by Orhan F1, Sekerel BE, Kocabas CN, Sackesen C, Adalioglu G, Tuncer A.(PubMed)
(1663) Asthma following royal jelly by Harwood M, Harding S, Beasley R, Frankish PD.(PubMed)
(1664) Effects of royal jelly supplementation on body weight and dietary intake in type 2 diabetic females by Pourmoradian S1, Mahdavi R2, Mobasseri M3, Faramarzi E1, Mobasseri M4.(PubMed)
(1665) Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial by Pourmoradian S1, Mahdavi R, Mobasseri M, Faramarzi E, Mobasseri M.(PubMed)
(1666) Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats by Takaki-Doi S1, Hashimoto K, Yamamura M, Kamei C.(PubMed)
(1667) Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats by Tokunaga KH1, Yoshida C, Suzuki KM, Maruyama H, Futamura Y, Araki Y, Mishima S.(PubMed)
(1668) Effect of Memo®, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment by Yakoot M1, Salem A, Helmy S.(PubMed)
(1669) Raw drone milk of honeybees elicits uterotrophic effect in rats: evidence for estrogenic activity by Seres AB1, Ducza E, Báthori M, Hunyadi A, Béni Z, Dékány M, Gáspár R.(PubMed)
(1670) Royal jelly has estrogenic effects in vitro and in vivo by Mishima S1, Suzuki KM, Isohama Y, Kuratsu N, Araki Y, Inoue M, Miyata T.(PubMed)
(1671) Effect of Royal Jelly on premenstrual syndrome among Iranian medical sciences students: a randomized, triple-blind, placebo-controlled study by Taavoni S1, Barkhordari F2, Goushegir A3, Haghani H4.(PubMed)
(1672) Towards a molecular definition of worker sterility: differential gene expression and reproductive plasticity in honey bees by Thompson GJ1, Kucharski R, Maleszka R, Oldroyd BP.(PubMed)
(1673) Effect of royal jelly ingestion for six months on healthy volunteers by Hiroyuki Morita,

1 Takahide Ikeda,1 Kazuo Kajita,1 Kei Fujioka,1 Ichiro Mori,1 Hideyuki Okada,1 Yoshihiro Uno,1 and Tatsuo Ishizuka.(PubMed)
(1674) Immune defense and antibacterial activity In-depth phosphoproteomic analysis of royal jelly derived from western and eastern honeybee species by Han B1, Fang Y, Feng M, Lu X, Huo X, Meng L, Wu B, Li J.(PubMed)
(1675) Royal jelly increases high density lipoprotein levels but in older patients only by Münstedt K, Henschel M, Hauenschild A, von Georgi R.(PubMed)
(1676) Effects of Royal Jelly Supplementation on Body Weight and Dietary Intake in Type 2 Diabetic Females by Samira Pourmoradian, 1 Reza Mahdavi, 2 ,* Majid Mobasseri, 3 Elnaz Faramarzi, 1 and Mehrnoosh Mobasseri(PubMed)
(1677) Royal jelly ameliorates insulin resistance in fructose-drinking rats by Zamami Y1, Takatori S, Goda M, Koyama T, Iwatani Y, Jin X, Takai-Doi S, Kawasaki H.(PubMed)
(1678) Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial by Pourmoradian S1, Mahdavi R, Mobasseri M, Faramarzi E, Mobasseri M.(PubMed)
(1679) [Effect of long-term treatment with royal jelly on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats].[Article in Japanese] by Nomura M1, Maruo N, Zamami Y, Takatori S, Doi S, Kawasaki H.(PubMed)
(1680) Study on the effect of royal jelly on reproductive parameters in streptozotocin-induced diabetic rats by Ghanbari E1, Nejati V1, Najafi G2, Khazaei M3, Babaei M2.(PubMed)
(1681) Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats by Amirshahi T1, Najafi G2, Nejati V1.(PubMed)
(1682) Antifatigue effect of fresh royal jelly in mice by Kamakura M1, Mitani N, Fukuda T, Fukushima M.(PubMed)
(1683) Antidepressant-like activity of 10-hydroxy-trans-2-decenoic Acid, a unique unsaturated Fatty Acid of royal jelly, in stress-inducible depression-like mouse model by Ito S1, Nitta Y, Fukumitsu H, Soumiya H, Ikeno K, Nakamura T, Furukawa S.(PubMed)
(1684) GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells by Okic-Djordjevic I1, Trivanovic D, Krstic J, Jaukovic A, Mojsilovic S, Santibanez JF, Terzic M, Vesovic D, Bugarski D.(PubMed)
(1685) Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells by Nakaya M1, Onda H, Sasaki K, Yukiyoshi A, Tachibana H, Yamada K.(PubMed)
References
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)

Most Common Diseases of 50plus: Thyroid disease: Hypothyroidism – Misdiagnosis and Diagnosis

Thyroid disease

Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.

Hypothyroidism

Hypothyroidism is a condition in which the thyroid gland is under active and produces very little thyroid hormones.

Misdiagnosis

1. Normal aging process and to the patient’s other health conditions
A diagnosis of hypothyroidism in the elderly can easily be overlooked if we rely exclusively on its clinical presentation because this may be highly non-specific, since the signs and symptoms of the disease are common to other diseases typical of old age, and even to the normal aging process. There is a report of a case of primary hypothyroidism that was diagnosed late because the correlated signs and symptoms (asthenia, bradycardia, pleural effusions, hyponatremia, worsening renal and respiratory insufficiency, hoarseness) had previously been attributed to the normal aging process and to the patient’s other health conditions (Parkinson’s disease, PD; chronic obstructive pulmonary disease, COPD)(40).

2. Reversal deterioration of renal function
There are a report of two patients with elevated serum creatinine levels due to primary autoimmune hypothyroidism, with complete recovery of creatinine clearance after thyroid hormone substitution therapy are presented. The first patient was a young male whose laboratory tests suggested acute renal failure, and the delicate clinical presentation of reduced thyroid function. The second patient was an elderly woman with a history of a long-term signs and symptoms attributed to ageing, including the deterioration of renal function, with consequently delayed diagnosis of hypothyroidism, according to the study by the Military Medical Academy, Clinic of Endocrinology(41).

3. Respiratory failure
There is a report of a 36 years male, admitted to the hospital for progressive respiratory failure. Chest X ray and CT scan were normal. On admission, a severe bradycardia and slow intellectual activity were noted. Serum thyroid function tests showed a TSH over 150 microU/ml and T3 of 75 ng/ml. Thyroid substitution therapy was associated with a progressive improvement of respiratory function, according to the study by the Servicio de Medicina del Hospital(42).

4. Brain stem infarct
Myxedema coma is the extreme form of untreated hypothyroidism. There is report of a patient with myxedema coma which was initially misdiagnosed as a brain stem infarct. The diagnosis of myxedema coma was often missed or delayed due to various clinical findings and concomitant medical condition and precipitating factors. It is more difficult to diagnose when a patient has no medical history of hypothyroidism, according to the study by the Hallym University(43).

5. Statin intolerance
There is a report of a case of Hypothyroidism misdiagnosed initially as statin intolerance, according to the study by Krieger EV, and Knopp RH(44).

6. Hypercholesterolaemia and simvastatin-induced myositis
There is a report of report of a 50-year-old woman who presented with hypertension. She was given simvastatin for hypercholesterolaemia. The creatine kinase level was 3180 U/L at the 3-month follow-up visit, which was thought to be due to simvastatin treatment. Although treatment was discontinued, the creatine kinase level 4 months later remained higher than 3000 U/L. Echocardiography revealed mild pericardial effusion and normal left ventricular function; the electromyogram was also normal. The patient subsequently showed signs and symptoms suggestive of hypothyroidism, which was confirmed by measurements of the concentration of thyroid-stimulating hormone (>100 mU/L) and free thyroxine (<2 pmol/L)(45).

The Diagnosis

If you are experience certain symptoms of above and/or have had previous thyroid problems or goiter. , your doctor may suspect that you have underactive thyroid. Your doctor may order blood test to measure the level of TSH and the level of the thyroid hormone thyroxine and triiodothyronine, depending to the stage of the diseases. According to the study by the College of Medicine, Mayo Clinic, hypothyroidism is the result of inadequate production of thyroid hormone or inadequate action of thyroid hormone in target tissues. Primary hypothyroidism is the principal manifestation of hypothyroidism, but other causes include central deficiency of thyrotropin-releasing hormone or thyroid-stimulating hormone (TSH), or consumptive hypothyroidism from excessive inactivation of thyroid hormone. Subclinical hypothyroidism is present when there is elevated TSH but a normal free thyroxine level(46).

General Health: Anemia - How to Avoid the deficient Causes

Phytochemicals in Foods - The Effects of Resveratrol

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Resveratrol

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape wine, nuts, peanuts, etc.

Health Benefits
1. Anti cancers
In the review of resveratrol and it effects as a chemopreventive agent, tumor initation, promotion, and progression via multiple pathways, indicated thatresveratrol exerts antioxidant activities, hence contributing to the prevention of tumor initiation. Growing or metastasizing carcinomas are inhibited by resveratrolthrough prevention of angiogenesis by inhibiting VEGF and matrix metalloproteases. Induction of apoptosis and cell cycle arrest, important mechanisms for cancer therapy, are stimulated by resveratrol through different mechanisms, e.g., activation of p53 and modulation of cell cycle proteins, according to "Fighting cancer with red wine? Molecular mechanisms ofresveratrol" by Kraft TE, Parisotto D, Schempp C, Efferth T.(1)

2. Anti cancers and anti inflammatory effects
In the observation of Resveratrol's effects in exhibition of several physiological activities including anticancer and anti-inflammatory activities in vitro and in experimental animal models, as well as in humans, found that Anticancer activity of this compound is mainly due to induction of apoptosis via several pathways, as well as alteration of gene expressions, all leading to a decrease in tumor initiation, promotion, and progression. Resveratrol exhibits anti-inflammatory activity through modulation of enzymes and pathways that produce mediators of inflammation and also induction of programmed cell death in activated immune cells. Resveratrolhas been shown to produce no adverse effects, even when consumed at high concentrations, according to "Potential of resveratrol in anticancer and anti-inflammatory therapy" by Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJ.(2)

3. Prostate cancer
In the evaluation of the tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) and the androgen receptor (AR) in tumor development and progression in prostate carcinogenesis, found that resveratrolmay act as potential adjunctive treatment for late-stage hormone refractory prostate cancer. More importantly, for the first time, our study demonstrates the mechanism by which AR regulates PTEN expression at the transcription level, indicating the direct link between a nuclear receptor and the PI3K/AKT pathway, according to "Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines' by
Wang Y, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C.(3)

4. Cardiovascular diseases
In the revie of reviews some of the key studies, and the known mechanisms for these beneficial effects. Evidence from different experimental studies, including from the authors' laboratories, and the beneficial effects of polyphenols found in red wine, especially resveratrol in grape skins.
found that Resveratrol benefits include a reduction in cardiovascular morbidity and mortality, lung cancer and prostate cancer by approximately 30% to 50%, 57% and 50%, respectively. Polyphenols possess antioxidant, superoxide-scavenging, ischemic-preconditioning and angiogenic properties. Some of these properties of polyphenols may explain their protective effects on the cardiovascular system, as well as other body organs, according to "Significance of wine and resveratrol incardiovascular disease: French paradox revisited" by

Vidavalur R, Otani H, Singal PK, Maulik N.(4)

5. Cardiovascular health
In the review of Resveratrol (3,4',5-trihydroxystilbene), a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems, indicated that Recently, resveratrol was found to induce autophagy and regenerate myocardial ischemic tissue treated with stem cells. Overall observation indicates that resveratrol has a high therapeutic potentials for the treatment of cardiovascular diseases, according to "Resveratroland cardiovascular health" by Das M, Das DK.(5)

6. Anti inflammatory effects
In the study of implantation and growth of metastatic cancer cells at distant organs is promoted by inflammation-dependent mechanism, found that resveratrolremarkably inhibited hepatic retention and metastatic growth of melanoma cells by 50% and 75%, respectively. The mechanism involved IL-18 blockade at three levels: First, resveratrol prevented IL-18 augmentation in the blood of melanoma cell-infiltrated livers. Second, resveratrol inhibited IL-18-dependent expression of VCAM-1 by tumor-activated hepatic sinusoidal endothelium, preventing melanoma cell adhesion to the microvasculature. Third, resveratrol inhibited adhesion- and proliferation-stimulating effects of IL-18 on metastatic melanoma cells through hydrogen peroxide-dependent nuclear factor-kappaB translocation blockade on these cells, according to "Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18" by Salado C, Olaso E, Gallot N, Valcarcel M, Egilegor E, Mendoza L, Vidal-Vanaclocha F.(6)

7. Oxidative stress and endothelial dysfunction
In the investiagtion of the role of S6K1 in aging-associated endothelial dysfunction and effects of the polyphenol resveratrol on S6K1 in aging endothelial cells, wrote that our data demonstrate a causal role of the hyperactive S6K1 in eNOS uncoupling leading to endothelial dysfunction and vascular aging. Resveratrolimproves endothelial function in aging, at least in part, through inhibition of S6K1. Targeting S6K1 may thus represent a novel therapeutic approach for aging-associated vascular disease, according to "Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition byresveratrol" by Rajapakse AG, Yepuri G, Carvas JM, Stein S, Matter CM, Scerri I, Ruffieux J, Montani JP, Ming XF, Yang Z.(7)

8. Insulin resistance
In the evaluation of the effects of Res on insulin sensitivity and the underlying mechanism, insulin-resistant KKA(y) mice were treated with 2 and 4 g/kg diets of Res for 12 weeks, found that Res intervention reduces blood glucose and serum insulin levels, improves insulin and glucose tolerance, increases serum adiponectin and adiponectin mRNA levels in epididymal adipose tissues, and more importantly, elevates Sirt1, p-AMPK, p-IRS1, and p-AKT levels in liver and soleus muscles, according to "Effects of resveratrol on the amelioration of insulin resistance in KKA(y) mice" by Chen S, Li J, Zhang Z, Li W, Sun Y, Zhang Q, Feng X, Zhu W.(8)

9. Propionibacterium acnes
In the investigation of whether P. acnes biofilms could be eradicated by plant extracts or their active compounds, and whether other mechanisms besides killing of biofilm cells could be involved, found that out of 119 plant in the study, researchers identified five with potent antibiofilm activity against P. acnes (extracts from Epimedium brevicornum, Malus pumila, Polygonum cuspidatum, Rhodiola crenulata and Dolichos lablab). We subsequently identified icariin,resveratrol and salidroside as active compounds in three of these extracts. Extracts from E. brevicornum and P. cuspidatum, as well as their active compounds (icariin and resveratrol, respectively) showed marked antibiofilm activity when used in subinhibitory concentrations, indicating that killing of microbial cells is not their only mode of action, accoridng to "Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds" by Coenye T, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, Nelis HJ.(9)

10. Healthy heart and longevity
In the review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action,
found that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice, according to "Resveratrol and red wine, healthy heart and longevity" by Das DK, Mukherjee S, Ray D.(10)

11. Antioxidants
In the assessment of the effects of the antioxidants resveratrol and quercetin on frozen-thawed ram sperm, found that Semen samples (which exceeded minimum standards) from four mature crossbreed Santa Inês rams were pooled and aliquots of each pool were diluted in Tris-egg yolk-glycerol, with the addition of 0, 5, 10, 15, and 20 μg/mL of resveratrol and quercetin in Experiment 1 and Experiment 2, respectively. In Experiment 1, the proportion of sperm with a high mitochondrial membrane potential was greater (P < 0.02) in the control group than in resveratrol20 μg/mL group. In Experiment 2, the proportion of sperm with high mitochondrial membrane potential was greater in the control group (P < 0.0001) than in the other experimental groups, and greater in the quercetin 5 μg/mL group (P < 0.05) than in the other quercetin-treated groups, according to "Effect of antioxidantsresveratrol and quercetin on in vitro evaluation of frozen ram sperm" by Silva EC, Cajueiro JF, Silva SV, Soares PC, Guerra MM.(11)

12. Incision-induced acute and chronic pain
In the searching for more efficacious treatments in inhibition of incision-induced pain and prevention of the transition to chronic pain following surgery, found that local injection of resveratrol around the surgical wound strongly attenuates incision-induced allodynia. Intraplantar IL-6 injection and plantar incision induces persistent nociceptive sensitization to PGE2 injection into the affected paw after the resolution of allodynia to the initial stimulus. We further show that resveratroltreatment at the time of IL-6 injection or plantar incision completely blocks the development of persistent nociceptive sensitization consistent with the blockade of a transition to a chronic pain state by resveratrol treatment, according to "Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain" by Tillu DV, Melemedjian OK, Asiedu MN, Qu N, De Felice M, Dussor G, Price TJ.(12)

13. Anti diabetes
In the evaluation of resveratrol, a polyphenolic SIRT1 activator and its SIRT1 activation in an in vitro fluorescent based assay (EC(50) : 7 μM) and the efficacy of resveratrol was also evaluated in ob/ob mice for its antidiabetic and associated metabolic effects, found that a significant improvement observed in the glucose excursion in the oral glucose tolerance test performed for 120 min; although an insignificant improvement in the triglycerides, total cholesterol, adiponectin and free fatty acid levels was observed at different doses of resveratrol tested. The present findings suggest that resveratrol is an antihyperglycemic agent and drugs similar to resveratrol can be considered as an effective therapeutic adjuvant for the current treatment of diabetes mellitus, according to "Antidiabetic activity ofresveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes" by Sharma S, Misra CS, Arumugam S, Roy S, Shah V, Davis JA, Shirumalla RK, Ray A.(13)

14. Neuroprotective effects
In the elucidation of the neuroprotective effect and influence of resveratrol on the extracellular levels of neurotransmitter and neuromodulator during ischemia/reperfusion in rats,
found that chronic treatment with resveratrol remarkably reduced the release of excitatory neurotransmitter glutamate, aspartate and neuromodulator d-Serine during ischemia and reperfusion; and significantly increased the basal extracellular levels of inhibitory neurotransmitter gamma-amino-n-butyric acid, glycine and taurine. Chronic treatment with resveratrol also ameliorated O-phosphoethanolamine levels and excitotoxic index during ischemia and reperfusio, according to "Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats" by Li C, Yan Z, Yang J, Chen H, Li H, Jiang Y, Zhang Z(14)

15. Neuroprotective effects
In the investigation of the neuroprotective properties of resveratrol found thatResveratrol has neuroprotective features both in vitro and in vivo in models of Alzheimer's disease (AD), but it has proved to be beneficial also in ischemic stroke, Parkinson's disease, Huntington's disease, and epilepsy, according to "Neuroprotective properties of resveratrol in different neurodegenerative disorders" by Albani D, Polito L, Signorini A, Forloni G.(15)

16. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20443159
(2) http://www.ncbi.nlm.nih.gov/pubmed/18667005
(3) http://www.ncbi.nlm.nih.gov/pubmed/20729295
(4) http://www.ncbi.nlm.nih.gov/pubmed/18651034
(5) http://www.ncbi.nlm.nih.gov/pubmed/20837050
(6) http://www.ncbi.nlm.nih.gov/pubmed/21569399
(7) http://www.ncbi.nlm.nih.gov/pubmed/21544240
(8) http://www.ncbi.nlm.nih.gov/pubmed/22309033
(9) http://www.ncbi.nlm.nih.gov/pubmed/22305279
(10) http://www.ncbi.nlm.nih.gov/pubmed/20238161
(11) http://www.ncbi.nlm.nih.gov/pubmed/22289215
(12) http://www.ncbi.nlm.nih.gov/pubmed/22269797
(13) http://www.ncbi.nlm.nih.gov/pubmed/20623590
(14) http://www.ncbi.nlm.nih.gov/pubmed/20026214
(15) http://www.ncbi.nlm.nih.gov/pubmed/20848560

General Health: Detoxification - Introduction, Causes, Preventions and Treatments

II. Causes
A. Internal Causes
1. Overdose of red meat
Our animals are grown in a crowded environment and fed by growth hormones to perverse the maximum profits. No matter how restricted the government regulations are, these traces of growth hormone still remain in the animal body causing more harm than good. Although our body requires protein and fat to function daily, overdose of red meat causes cholesterol building up in the arteries, triglyceride in the bloodstream, and high blood pressure resulting in heart diseases and chronic illness.

2. Overdose sugar
Carbohydrates are essential to our liver and kidney function, overdose of sugar in American diet causes insulin resistance, damaging the pancreas, reducing the circulation of blood and causing hormone imbalance.

3. Excessive drinking
Our social life is a mess. We drink too much. Since alcohol is a stimulant, moderate drinking helps increase the circulation of blood and improve mental alertness. Excessive drinking reduces the brain's function, damaging our liver, decreasing the function of the immune system and causing inflammation.

4. Artificial Agents
Artificial agents may help to perverse food and make it look good, but they are toxic to our body. These types of agents stimulate appetite by directly influencing the hunger centers of the brain causing you to eat more resulting in obesity.

5. Smoking
Smoking not only causes lung cancer, it also causes the depletion of oxygen levels in the bloodstream, increasing the risk of hardening, thickening and calcium attached in arterial wall as well as increasing the risk of heavy metals accumulating in our brain.

6. Consuming not enough fruits and vegetables
Fruits and vegetables are high in nutrients that are vital for daily function of our body. Vitamins C, E, K and chemical substances in fruits and vegetables such as alpha carotene, beta carotene, selenium, chlorophyll, and amino acid are powerful antioxidants that not only helps to increase body metabolism, it also helps in strengthening our immune system against fighting the forming of free radicals as well as protecting our body by fighting against inflammation caused by bacteria and virus.

B. External Causes
1. Air Pollution
The cause of air pollution are the result of burning of fossil fuels such as coal, oil, natural gas, and gasoline to produce electricity and power our vehicles such as the emitting of carbon dioxide resulting in ozone pollution, acid rain, and toxic heavy metal pollution. Yes, this is the air we breath very day. Every breath we inhale, our body is required to detoxify all this harmful material entering our body. If you have a weakened immune system, some of these harmful can not be removed from our body resulting in heavy metal accumulation as well as disrupting the normal function of organs causing inflammation and infection.

2. Soil Pollution
Soil pollution are caused by misuse of the soil in poor agricultural practices, mineral exploitation, industrial waste dumping, and indiscriminate disposal of urban wastes. These kinds of wastes accumulating in our soil include herbicides, pesticides, heavy metals and man-made chemicals that will enter our body through raining, snowing and foods. If our body cannot get rid of them long term accumulation of these harmful substances will result in a weakened immune system and chronic diseases.

3. Water pollution
An estimated 90% of waste water are discharged directly into rivers and streams without treatment. There are as many causes of water pollution such as poorly designed landfills, road deicing salts, and hazardous waste sites resulting in heavy metals and harmful chemical substances entering the water that we drink everyday.

4. Indoor pollution
Indoor pollution such as gas heaters, gas appliances, wood burning fireplaces, leaking chimneys and furnaces, and tobacco smoke causes allergic reactions such as eye, nose and throat irritation, and weakening our immune system.

5. Toxins in Food
Certain foods are more toxic than others, such as french fries, BBQ chicken, and most fast foods which contain a high quantity of trans-fat that has been shown to be carcinogenic. Fruits and vegetables grow in the contaminated soils or herbicides are used on them, pesticides will absorb the contamination substances and have poor nutrition.

III. Prevention and Treatment
1. Liver cleansing
a) Milk thistle
Milk thistle, a flower plant of the daisy family have been traditionally claimed in treating chronic liver disease. It contains silymarin that helps to protect liver function and the liver in expelling toxins.

b) Licorice
Licorice is a legume plant and and native to southern Europe and parts of Asia. It contains glycyrrhizin that not only has both estrogenic and anti-estrogenic activity but also is an important liver herb with strong hepatoprotectant properties in treating the suppression of hepatic stellate cell activation and subsequent liver fibrosis.

c) Tabebuia heptaphylla
Tabebuia heptaphylla is also known as pink trumpet tree. It contains alkaloids, flavonoids, sulfur and essential oils helping to support the immune system, and it also has antifungal, antibacterial and antibiotic properties. It is a powerful antioxidant that helps to cleanse toxins accumulated in the liver as well as protecting the forming of cancerous cells in the prostate.

d) Stilingia root
Stilinga root not only helps to strengthen the immune cells but also prevent and treating food allergies and eczema by stimulating the removal of toxins accumulation in the liver caused by long term eating of preservatives, canned foods, fast foods and excessive alcohol drinking.

e) Pricky ash
Pricky ash is also known as toothache tree. It has been used traditionally as a digestive aid, to strengthen the nervous system. It also is a tonic and stimulant herb for the liver and gallbladder.

f) St. John wort
St. John wort is also known as tipton weed or klamath weed. It has been used traditionally in treating depression. It contains different flavonoids and 3-O-coumaroylquinic acid that has anti-inflammation and antioxidant effects by stimulating the immune system in fighting allergies and liver protection from toxins.

g) Fennel
Fennel contains anethole, polymers and essential oil that helps the liver and pancreas in the metabolism of fats and sugars. It also helps to dissolve fat deposits of the body and restore damaged liver cells that cause jaundice, hepatitis and other liver disorders.

2. Kiddey cleansing

a) Dandelion leaf
Dandelion is a rich source of vitamins A, B complex, C, and D, as well as minerals such as iron, potassium, and zinc. Dandelion root has been used for centuries in traditional Chinese medicine in treating liver disease by stimulating the removal of liver toxins. Dandelion leaf on the other hand are used as a diuretic to stimulate the excretion of urine in removing the toxin accumulated in the kidney.

b) Echinacea
Commonly called purple coneflower. It contains a wide variety of chemicals that not only helps to strengthen the immune system but also stimulates the removal of toxins that causes kidney inflammation and infection.

c) Corn silk
Corn silks are the silky fibers that are found under the leaves and on top of an ear of corn. It contains flavonoids, essential oil and minerals that helps effectively in treating acute and chronic inflammation of the urinary system caused by toxins accumulated in the kidney.

d) Apple
Apples contain high amounts of vitamins A, C, E and a variety of antioxidants that not only help in strengthening our immune system but also help to cleanse our kidney from toxins through urinary extraction and preventing kidney inflammation.

e) Artichoke
Artichoke is a perennial thistle originating from southern Europe containing thiamin, riboflavin, niacin. These are antioxidants that besides helping strengthen our immune system, it also is used to treat kidney diseases and protein in the urine caused by toxins through poor diet for a prolonged period of time.

f) Golden rod
Golden rod is a yellow flowering plant in the family of Asteraceae. Golden rod has been used in traditional medicines as a kidney tonic, and treating urinary infections and stones. Golden rod juice also helps to cleanse of kidney and bladder caused by toxins and inflammation.

3. Skin cleansing
a) Chromium
Chromium is very important in rejuvenating the skin condition. It helps to balance the blood sugar, and lower stress and depression. Both are main factors that impact skin problems. It also helps to get rid of skin toxins caused by bacteria and virus infection.

b) Zinc
Deficiency of zinc causes the thickening of skin. It is also a powerful antibiotic in treating acne and other forms of skin diseases caused by skin inflammation and toxins accumulation as a resulting of stimulating the release of vitamin A from the skin.

c) Lecithin
Lecithin is a fat-like substance, or phospholipid, produced by every healthy liver that is needed for a healthy skin. Lecithin helps the body in utilizing vitamins A, D, E in fighting against the bacteria and virus that causes skin problems. It also helps to eliminate the toxins on the skin or around the eyes caused by fatty deposits.

d) Strawberry leaf
Strawberries come in endless varieties but all leaves of all strawberries contain healing tannins. It has also been used to aid in the treatment of anemia, eczema, jaundice and other skin problems caused by weakening of the liver.

e) Burdock root
Burdock has traditionally been used in treating chronic skin ailments such as eczema psoriasis, and dermatitis. It also helps to purify the bloodstream of toxins causing skin diseases.

f) Oats
Oats contain antioxidants such as IP-6, vitamin E, and zinc that is not only needed for a healthy heart and prostate gland but also help in rejuvenating our skin by fighting against inflammation in the skin caused by toxin accumulation or bacteria infection.

4. Colon Cleansing
a) Flax seed
Flax seed contains high amounts of omega 3 fatty acid, fiber and lignan that not only helps in controlling cholesterol in the blood stream and provides essential nutrition to our body, its fiber also helps to soften the stool and promote bowel movements for relief of constipation by removing all toxins accumulated in the colon.

b) Psyllium
Psyllium contains about 70% soluble fiber and 30% insoluble fiber. Besides having proven record in Chinese medicine in treating high levels of cholesterol, its fiber portion has been used to treat constipation by softening stools and easing bowel movements.

c) Bentonite
Bentonite is a natural clay that comes from volcanic ash. Taken internally, the adsorbent action of bentonite helps to eliminate and remove toxic material from the intestine.

d) Liquid clay
Liquid clay moves through our body and attaches to any bacteria, virus as well as toxins in our intestine and removes them out of our body as wastes resulting in improved intestinal regularity, easing chronic constipation and easing indigestion.

e) Buckthorn bark
Buckthorn bark is native to Europe and parts of western Asia. It contains anthraquinones that stimulate intestinal movement and also attracts more water to the intestines resulting in a softened stool and removing toxins accumulated in the intestine out as wastes.

f) Rhubarb root
Rhubarb root has been used in Chinese medicine in treating both constipation and diarrhea. Intake of rhubarb root helps to improve intestine tone, as well as remove toxins from the intestine.

g) Cascara sagrada
Cascara sagrada is known to tone the relaxed intestinal muscles in the digestive system. Intake of cascare sagrada helps promote the digestive process in people affected by disorders in the digestion as well as chronic constipation.

5. Lung cleansing
a) Lotus Root Tea
Made from the root of the esteemed Asian water lily. It helps
dissolve and eliminate mucus and lung congestion over time. Lotus
root traditionally has been used to neutralize toxins accumulated in
the lung as well as in treating of other respiratory diseases such
as asthma, tuberculosis, coughing.

b) Platycodon Root
Platycodon has been used in Chinese medicine for over a century
in treating of abscesses, respiratory disorders, intestinal disorders.
Study shows that platycodon roots not only helps to treat cough
due to purulent sputum and inflammation in the chest area but
also removes toxins in the lung.

c) Wild Cherry Bark
Wild cherry bark traditionally has bee used irritable and persistent
cough of bronchitis, pertussis, cough due to increased irritability
of respiratory mucosa. Because of its antispasmodic qualities, it
has been used with other herbs to treat asthma and enhance
relaxation as well as removing toxins from the lung.

d) Mullein
Mullein contains coumarin and rotenone. It has a long history of
use as a medicine and is an effective treatment for asthma
and respiratory disorders.Mullein also helps in soothing the mucous
membranes, reducing inflammation and encouraging healthy fluid
production in the lungs.

e) Ephedra
Epphedra has been used in Chinese medicine traditionally for 5,000
year in treating of asthma and hayfever and common cold. It also
helps to support healthy sinus nasal lung and respiratory function
by removing toxins in the lung.

f) Elecampane
Elecampane also called horse-heal. It has been used for treatment
of the shortness of breath and helps to promote a strong lung.
Elecampane is a wonderful lung tonic. Useful for asthma, soothing
to the lining of the lungs

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Kidney Yin deficiency - Huang Lian

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

Management and Treatment according to Traditional Chinese Medicine Perspective

While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.

Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Kidney yin deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yin deficiency may also experience yin vacuity induced cold expressive syndrome, including soreness of waist and knees(1848), lassitude(1848) and fatigue(1848), short breath(1848), poor appetite(1848), aversion to cold(184), cold extremities(1848), ringing in the ears(1850), migraine(1849), hearing problems(1850), a dry mouth and throat(1851), pale fingernails(1851), tidal fever(1851)and night sweating(1851), soles(1851) and chest(1851), constipation(1852),,......... as the kidneys no longer perform their functions of regulating fluid in moistening and nourishing organs and tissues of the body. According to TCM, too much cold/raw foods can aggravate the condition.

In the review of the Data base provided by PubMed, kidney yin deficiency may induce functional impairment or metabolic derangements in vital organs/tissues(1853) persuaded a conglomeration of sundry chronic disease state(1853), cognitive dysfunction(1854), vasomotor symptoms(1855),..... leading to accumulation of fluid in the body organ, promoted accentuation of inflammatory development of phlegm.
Kidney yin deficiency has shown to alter amino acid metabolism(1856), energy metabolism(1856) and gut microflora(1856), anovulatory infertility(1857) and
hypertension(1858), hyperinsulinemia(1859) and hyperandrogenia(1859)..... of which related to symptoms of PCOs(1859).

Herbal medicine for Kidney yin deficiency

6. Huang lian
Hu huang Lian or Huang Lian is also known as coptis rhizome. The bitter and cool herb has been used in TCM as anti palette coagulation(2037)(2038), anti arrhythmia(2039)(2040), anti heart failure(2039), anti diabetic(2041)(2042), anti cancer(2044)(2045)(2046), anti inflammatory(2049)(2050) and antioxidant(2048)(2047) advocate and to relief heat toxicity(2051)(2052), indigestion(2053), inflammation of small intestine(2053), diarrhea(2054)(2055), fever(2054), jaundice(2054), insomnia(2056) and relieve pain(2055),,,,,,,,,, as it eliminates empty-Heat and Damp-Heat, clears Heat, etc., by enhancing the functions of heart, large intestine, liver, and stomach channels(2043)

Chemical Constutuents(2043)
1. Berberine
2. Colchicine
3. Coptisine
4. Worenine
5. Palmatine
6. Jatrorrhizine
7. Magnoflorine
8. Kutkin
9. Etc.

Berberine and chemical compound found in huang lian and the whole itself have shown a positive effect in reduced risk of diabetes(2041)(2042) and cardiovascular disease(2057)(2039)(2040)(2058) in women with kidney yin deficiency induced PCOs due to their glucose and lipid metabolism responds(2061) on metabolic syndrome(2064)(2069), including glucose level(2061)(2062), insulin resistance(2059)(2060)(2062), hypertensive(2065)(2066), hyperglycaemia[total cholesterol, triglyceride levels, urinary protein excretion, serum creatinine (Scr) and blood urea nitrogen (BUN)](2062)(2063)(2064) anti hyperglycaemic(2042)(2064), obesity(2064)(2067)(2068),.......via immunomodulatory(2070)(2071), antioxidant(2041)(2047)(2048)and anti-inflammatory activities.

Unfotunately, according Shanghai University of Traditional Chinese Medicine, increasing the systemic exposure of Rhizoma coptidis alkaloids(2071) and over doses of all alkaloids, especially berberine(2072) may induce risk of the acute toxicity.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
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(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
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(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao(1848) ontrolled trail on moxibustion for maintenance hemodialysis patients in deficiency syndrome]. [Article in Chinese] Li N1, Qiu MY, Hao JR, Zhang QM, Wang SH, Liang F, Yin Y, Luan J, Ge GZ, Qin T, Li BQ.(PubMed)

(1848) ontrolled trail on moxibustion for maintenance hemodialysis patients in deficiency syndrome]. [Article in Chinese] Li N1, Qiu MY, Hao JR, Zhang QM, Wang SH, Liang F, Yin Y, Luan J, Ge GZ, Qin T, Li BQ.(PubMed)
(1849) [Observation on therapeutic effect of the new Bianshi (stone needle) therapy on migraine]. [Article in Chinese] Yin ZJ1, Yan YJ, Bao HL(PubMed)
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Women Health: Menstrual Disorder - Dysmenorrhea - Symptoms of Kidney Yang Deficiency In TCM Perspective

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All women are experience menstruation disorders sometime during their child bearing years before menopause. While Western medication has never viewed that irregular menstruation is a problem of a women's reproductive system, traditional Chinese medicine looks at this problem seriously. If untreated, it will dis-harmonize the women's ecosystem, leading to nervous tension and other health problems, including infertility.
Kidney is vital for nourishing and moistening the body and supporting the function of the uterus in the natural process of conception. Deficiency of kidney yang interferes with the normal process of the menstrual cycle and fertility.

Dysmenorrhea

Dysmenorrhea (painful menstruation) is defined as a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of over production of certain hormones in the prostaglandins family. In traditional Chinese medicine, dysmenorrhea is defined as a pain in the lower abdomen, appearing with menstrual cycle that can spread over to the whole abdomen and lumbosacral region, depending to diagnosis.

The Symptoms

Symptoms of imbalance of kidney yang deficiency include:
1. Cold and pain in the lower abdomen during or after menstruation
Since kidney yang is important to warm and support the uterus for a healthy conception, deficiency of kidney yang causes cold to accumulate in the womb which interferes with the normal function of the kidney in regulating the temperature of the uterus, leading to muscle contraction, resulting in lower abdominal cramps and pain.

2. Small volume of dark menstrual discharge
Spleen is important to assist the heart in transporting blood to the reproductive organs and to support the kidney in nourishing and moistening the body's blood vessels. Deficiency of yang reduces blood and fluid in the reproductive organs, leading to a small volume of dark menstruation.

3. Weak and aching lower back and legs
Yang is necessary to support the daily activity in the body. Deficiency of yang causes constriction of the lower back and leg muscles.

4. Deep and weak pulse
Deficiency of yang causes slow movement of blood, leading to deep and weak pulse.

5. Pale tongue
Yang is required for blood circulation, deficiency of yang causes an abnormal function of the liver in blood storing and formation, leading to blood and qi stagnation, resulting in pale complexion.