Medical Advisor Journals

Tuesday, July 12, 2016

Food therapy - Fruits - Apple (Malus domestica)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Apple (Malus domestica)

Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae. It is one of the most widely cultivated tree fruits. The tree is originated in Central Asia.

Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
5. Vitamin A equiv.
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (Vitamin B5)
10. Vitamin B6
11. Folate
12. Vitamin C
13. Calcium
14. Iron
15. Magnesium
16. Phosphorus
17. Potassium
18. Zinc
19. Etc

Health Benefits
A. Health benefits according to studies
1. Helicobacter pylori
In the investigation of polyphenols of apple peel and theirs effect on Helicobacter pylori found that In a short-term infection model (C57BL6/J mice), two levels of APPE doses (150 and 300 mg/kg/day) showed an inhibitory effect on H. pylori attachment. Orally administered apple peel polyphenols also showed an anti-inflammatory effect on H. pylori-associated gastritis, lowering malondialdehyde levels and gastritis scores, according to "In vitro and in vivo effects of applepeel polyphenols against Helicobacter pylori" by Pastene E, Speisky H, García A, Moreno J, Troncoso M, Figueroa G.(a)

2. Anti cancersIn the study of the inverse relationship between the consumption of apples and the risk of several cancers found that APE treatment resulted in a marked increase in maspin, a tumor suppressor protein that negatively regulates cell invasion, metastasis, and angiogenesis. Our data suggested that APE possesses strong antiproliferative effects against cancer cells, and apple peels should not be discarded from the diet. Detailed mechanistic studies, especially in appropriate in vivo animal models, are needed to further examine the antiproliferative and preventive effects of APE against cancer, according to "Antiproliferative effects of apple peel extract against cancer cells" by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(b)

3. Anti-inflammatory effectIn the assessment of apple peel polyphenol extract (APPE) and its powerful antioxidant activity in protective effect against gastrointestinal damage found that APPE also displayed anti-inflammatory effects by preventing neutrophil infiltration in the mucosa, as evidenced by the lower myeloperoxidase activity. These protective effects of APPE resulted in the prevention of macro- and microscopic damage and of barrier dysfunction along the gastrointestinal tract of the indomethacin-treated animals. This study supports the concept that apple peel polyphenols may be useful in the prevention and/or treatment of nonsteroidal anti-inflammatory drug-associated side effects, according to "Apple peel polyphenols protect against gastrointestinal mucosa alterations induced by indomethacin in rats" by Carrasco-Pozo C, Speisky H, Brunser O, Pastene E, Gotteland M.(c)

4. CholesterolsIn the evaluation of consumption of a pear, an apple and 200 ml orange juice, during 26 days and theirs effect cholesterol found that fruit consumption increased TAC in non-smokers, but not in smokers. In non-smokers, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol increased significantly; while in smokers, total cholesterol and low-density lipoprotein-cholesterol decreased. We may conclude fruit/juice supplementation showed different effects, depending on the smoking habit: in non-smokers it increased TAC and cholesterol; in smokers it reduced cholesterol, without inducing a TAC increase, according to "Daily consumption of apple, pear and orange juice differently affects plasma lipids and antioxidantcapacity of smoking and non-smoking adults" by Alvarez-Parrilla E, De La Rosa LA, Legarreta P, Saenz L, Rodrigo-García J, González-Aguilar GA.(d)

5. Antioxidants In the observation of intake of apple and grape juice and theirsantioxidant effect found that apple and grape juice consumption did not influence lymphocyte damage upon hydrogen peroxide treatment. Urinary 8-hydroxy-2-deoxyguanosine content was not affected by 2 weeks of fruit juice intervention. These findings indicated that concomitant intake of apple and grape juice was efficient in enhancing the body's antioxidant status, according to "Impact of appleand grape juice consumption on the antioxidant status in healthy subjects" by Yuan L, Meng L, Ma W, Xiao Z, Zhu X, Feng JF, Yu H, Xiao R.(e)

6. Etc.

B. Health benefits according to concentration
1. Dietary fiberDaily intake of right amount of fibers can prevent and treat
a. Diabetes, as Increased consumption of vegetables, whole grains, and soluble and insoluble fiber is associated with improved glucose metabolism in both diabetic and nondiabetic individuals. Improvements in insulin sensitivity and glucose homeostasis were more evident in participants following a plant-based diet compared with other commonly used diets, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F.(I)

b. Cholesterol and cardivascular diseases, as the soluble fiber content of legumes and vegetables has also been shown to decrease LDL-C. Current investigations continue to explore this area in depth and examine potential synergies between dietary fiber and other phytochemicals that may lower cholesterol, according to the study of "Effects of soluble dietary fiber on low-density lipoprotein cholesterol and coronary heart disease risk" by Bazzano LA.(II)

2. Vitamin CBesides is essential in preventing the breaking off small vein cause of hardening of the vessel wall, vitamin C also improves the digestive system in maximum absorption of vital nutrients. Overdoses can cause diarrhea, It also plays an important role in enhancing immune system fighting against the forming of free radicals that cause muscle damage, according to the study of "Doesantioxidant vitamin supplementation protect against muscle damage?" by McGinley C, Shafat A, Donnelly AE., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/19902983)

3. MagnesiumMagnesium not only important for bone health, according to the study of "Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis?" by Odabasi E, Turan M, Aydin A, Akay C, Kutlu M(III) but also play and important role in protecting against Alzheimer's disease, according to the study of "Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease" by Barbagallo M, Belvedere M, Di Bella G, Dominguez LJ.(IV)

4. PhosphorusBeside providing strength to bones and teeth by working together with calcium according to the study of `[The effect of one year therapy with recombinant human growth hormone (rhGH) on growth velocity, calcium-phosphorus metabolism, bone mineral density and changes in body composition in children with growth hormone deficiency (GHD)].[Article in Polish]`by Zak T, Basiak A, Zubkiewicz-Kucharska A, Noczyńska A., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20529605), it also works with riboflavin and niacin to improve the digestive system in absorbing vital nutrients.

5. PotassiumPotassium beside is important for sympathetic function in regulating body fluid, it also plays an essential role in enhancing the nervous system in information transmitting within the nerves in the brain. According to the article of "POTASSIUM DEFICIENCY IN THE RABBIT AS A CAUSE OF MUSCULAR DYSTROPHY " by E. L. HOVE AND JOHN F. HERNDON Department of Animal Husbandry and Nutrition, Alabama Polytechnic Institute, Auburn, researchers wrote in summary that Potassium-deficient rabbits usually developed a severe and rapidly progressing muscular dystrophy, with a closely associated creatinurea.

6. Etc.
C. Other health benefits

1. Colon cancer and Cancers
Research suggests that apples may reduce the risk of colon cancer, according to "Modified apple polysaccharides could induce apoptosis in colorectal cancercells" by Li Y, Niu Y, Wu H, Sun Y, Li Q, Kong X, Liu L, Mei Q.(1) and several types of cancer, according to "Antiproliferative effects of apple peel extract against cancer cells" by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(2)

2. Immune system
Since it contains a measurable amount of antioxidant, it improves the immune system functioning in preventing and scavenging the forming of free radical, leading to reduction of DNA damage in Caco-2 cells according to "Polyphenolicapple extracts: effects of raw material and production method on antioxidanteffectiveness and reduction of DNA damage in Caco-2 cells" by Bellion P, Digles J, Will F, Dietrich H, Baum M, Eisenbrand G, Janzowski C.(3)

3. Nervous system
Apple increases the production of the neurotransmitter acetylcholine that prevents potential decline in cognitive performance that accompanies dietary and genetic deficiencies and aging, according to "Apple juice concentrate prevents oxidative damage and impaired maze performance in aged mice" by Tchantchou F, Chan A, Kifle L, Ortiz D, Shea TB.(4)

4. Other health benefits
Since apple contains high amounts of quercetin, epicatechin, and procyanidin B2 which help to reduce the risk of heart disease, cancerabe polyphenol, resveratrol, is believed to have potent anti-aging effects.

5. Etc.

Side effects
1. Oral allergy syndrome is an allergic reaction some people, leading to symptoms of itching and swelling around the mouth and lips, etc.
2. Amygdailin
The seeds are mildly poisonous, since it contains a small amount of amygdalin.
3. Etc.

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/20486708
(b) http://www.ncbi.nlm.nih.gov/pubmed/20432173
(c) http://www.ncbi.nlm.nih.gov/pubmed/21548634
(d) http://www.ncbi.nlm.nih.gov/pubmed/20109132
(e) http://www.ncbi.nlm.nih.gov/pubmed/21639820

(I) http://www.ncbi.nlm.nih.gov/pubmed/20713332
(II) http://www.ncbi.nlm.nih.gov/pubmed/18937894
(III) http://www.ncbi.nlm.nih.gov/pubmed/18695768
(IV) http://www.ncbi.nlm.nih.gov/pubmed/21951617

(1) http://onlinelibrary.wiley.com/doi/10.1111/j.1750-3841.2010.01781.x/suppinfo
(2) http://www.ncbi.nlm.nih.gov/pubmed/20432173
(3) http://www.ncbi.nlm.nih.gov/pubmed/20455581
(4) http://www.ncbi.nlm.nih.gov/pubmed/16340085

Most Common Diseases of 50plus: Disease of CNS -: Alzheimer's Disease(AD) Research and studies - The effects of Vitamin D

Alzheimer's disease is a brain disorder correlated with major reduction of neurons to the respective target areas through destruction of brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.
According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.
Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including salmon, mackerel, sardines and tuna. The vitamin plays an important role in modulation of cellular proliferation, apoptosis induction, tumor growth suppression and promotion in absorption of minerals, including calcium, iron, magnesium, phosphate and zinc.

The effects of Vitamin D

1. Vitamin D receptors(VDR)
Vitamin D receptors, also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), with functions of regulation in many metabolic pathways, including cancers, play an important role in risk of Alzheimers' disease. Polymorphisms in the vitamin D receptor (VDR), and insufficient serum 25 hydroxyvitamin D3 levels patients have been found to associate with age- dependent cognitive decline(1). The study of Vitamin D(3), a neurosteroid that mediates its effects via the vitamin D receptor (VDR) also indicated a possible link between AD and certain VDR polymorphisms in early onset of AD(2) through suppression of VDR by Aβ(3). Treatment of Vitamin D was found effectively in inhibition of Aβ induced alterations in primary cortical neurons(4). The Istanbul University in study of the association of between VDR gene and late-onset Alzheimer's disease (AD) with 104 cases of dementia of Alzheimer type and 109 age-matched controls, showed an significant increased Aa genotype in AD patients than health individuals with the same genotype, of that may be an indication of "Aa" genotype associated to increased risk of developing AD. In the comparison of "AA" genotype, risk of AD in men with Aa genotyes are 2.3 times higher(5).

2, Plasma of vitamin D
Suggestion of serum levels of vitamin D used as diagnosis for indication of early onset of Alzheimer's' diseases may be controversial. Some researchers suggested that lower plasma nutrient levels only a indication for impaired systemic availability of several nutrients in AD(6). The Kingston University study showed level of 25hydroxyvitamin D (25OHD) was found to be lower in patients with the disease, arising from extremely low levels of 25OHD2 along with low levels of 25OHD3.(7). In the study of the correlation of Alzheimer's disease and osteoporosis, the Heinrich-Heine-University showed that 25 (OH) vitamin D plasma levels were low normal and of equal amount in all groups except for the osteoporosis group(8).

The benefits
Epidemiological studies, focusing vitamin D and its derivative in reduced risk of Alzheimer's diseases have not been consistent. Researchers indicated that Gene polymorphisms alternation of vitamin D metabolism are also associated with a higher incidence or a worse disease prognosis, and despite the links betweenvitamin D deficiency and the risks of developing neurological disorders, there is, to date, no proof that supplementation could alter the course of these diseases(9). Study of the effects of vitamin D showed an indication of prevention of neurons cytotoxicity and apoptosis through downregulating LVSCC A1C(L-type voltage-sensitive calcium channel with function of gene expression, synaptic efficacy, and cell survival) and upregulating VDR and balancing nerve growth factor (NGF) expressions(10). Researchers at the 1Vietnamese American Medical Research Foundation, suggested that vitamin D supplements appeared beneficial to patients of AD through many mechanisms including regulating micro-RNA, enhancing toll-like receptors, modulating vascular endothelial factor expression, angiogenin, and advanced glycation end products, etc.(11). The combination of memantine with vitamin D, a neurosteroid hormone, in the joint study, showed an evidence lesser cortical axons degeneration after exposure to amyloid-beta peptide or glutamate in microfluidic neuronal cultures.(12). Unfortunately, regardless to the effectiveness of vitamin D in reduced risk of cognitive impairment or Aβ, many researchers still believed that there is no truly effective therapy has been developed for Alzheimer's disease or mild cognitive impairment(13).

Taking altogether, without going into reviews, vitamin D may be considered as a therapeutic treatment in reduced risk of Alzheimers' diseases, through many mechanisms, including induction of Aβ, regulation of micro-RNA expression, etc.. Over doses of vitamin D supplement may cause excessive calcium absorption, calcification, Urinary stones etc. please make sure to follow the guideline of the Institute of Medicine of the National Academies.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) A novel perspective for Alzheimer's disease: vitamin D receptor suppression by amyloid-β and preventing the amyloid-β induced alterations by vitamin D in cortical neurons by Dursun E1, Gezen-Ak D, Yilmazer S.(PubMed)
(2) Vitamin D receptor gene haplotype is associated with late-onset Alzheimer'sdisease.
Gezen-Ak D1, Dursun E, Bilgiç B, Hanağasi H, Ertan T, Gürvit H, Emre M, Eker E, Ulutin T, Uysal O, Yilmazer S.(PubMed)
(3) A new mechanism for amyloid-β induction of iNOS: vitamin D-VDR pathway disruption by Dursun E1, Gezen-Ak D, Yilmazer S(PubMed)
(4) A novel perspective for Alzheimer's disease: vitamin D receptor suppression by amyloid-β and preventing the amyloid-β induced alterations by vitamin D in cortical neurons by Dursun E1, Gezen-Ak D, Yilmazer S(PubMed)
(5) Association between vitamin D receptor gene polymorphism and Alzheimer'sdisease.

Gezen-Ak D1, Dursun E, Ertan T, Hanağasi H, Gürvit H, Emre M, Eker E, Oztürk M, Engin F, Yilmazer S.(PubMed)
(6) Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis by Lopes da Silva S1, Vellas B, Elemans S, Luchsinger J, Kamphuis P, Yaffe K, Sijben J, Groenendijk M, Stijnen T.(PubMed)
(7) Low 25OH vitamin D2 levels found in untreated Alzheimer's patients, compared to acetylcholinesterase-inhibitor treated and controls by Shah I1, Petroczi A, Tabet N, Klugman A, Isaac M, Naughton DP.(PubMed)
(8) Blood biomarkers of osteoporosis in mild cognitive impairment and Alzheimer'sdisease by Luckhaus C1, Mahabadi B, Grass-Kapanke B, Jänner M, Willenberg H, Jäger M, Supprian T, Fehsel K.(PubMed)
(9) [Vitamin D and neurology].[Article in French] by Thouvenot É1, Camu W(PubMed)

(10) The Effects of Vitamin D Receptor Silencing on the Expression of LVSCC-A1C and LVSCC-A1D and the Release of NGF in Cortical Neurons by Duygu Gezen-Ak, Erdinç Dursun, and Selma Yilmazer(PubMed)
(11) The role of vitamin D in Alzheimer's disease: possible genetic and cell signaling mechanisms by Lu'o'ng KV1, Nguyen LT.(PubMed)
(12) Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate by Annweiler C1, Brugg B, Peyrin JM, Bartha R, Beauchet O(PubMed)

The Best Weight Loss and Healthy Recipe - A Mayonnaise-like dressing

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Best Weight Loss and Healthy Recipe - A Mayonnaise-like dressing

Diabetic recipes. Attributed to Delicious Dish for diabetics by Robin Ellis, Published by Skyhorse Publishing Inc. New York. You can view its website atwww.skyhorsepublishing.com.

Not as soft and unctuous of course, but good with salmon, for instance and asparagus, and does not involve the irksome though rewarding business of making mayonnaise! Heresy, I know.....
1 tbsp. cider vinegar
1 tsp. Dijon mustard
juice of 1/4 of a lemon
4 - 5 tbsp. extra-virgin canola/colza oil.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

General Health: Angina pectoris - The Diet

The aims of the diet is to reduce the unhealthy diet and coronary artery diseaserisk factors causes of Angina pectoris, the symptom of Ischemic heart disease
1. Avocados are a commercially valuable fruit and are cultivated in tropical climates throughout the world, it is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America and Central America, belonging to the flowering plant family Lauraceae.
a. Cholesterol
In the determination of the atherogenicity of avocado oil relative to saturated (coconut oil), monounsaturated (olive oil) and polyunsaturated (corn oil) fats found that Coconut oil was the most atherogenic fat. Corn oil was only slightly less atherogenic than either olive or avocado oils. Percentage of serum HDL cholesterol was highest in the rabbits fed the two monounsaturated fats, according to "Cholesterol vehicle in experimental atherosclerosis 24: avocado oil" by Kritchevsky D, Tepper SA, Wright S, Czarnecki SK, Wilson TA, Nicolosi RJ.(21)

b. Dietary fiber
Daily intake of right amount of fibers can prevent and treat Diabetes. Increased consumption of vegetables, whole grains, and soluble and insoluble fiber is associated with improved glucose metabolism in both diabetic and nondiabetic individuals. Improvements in insulin sensitivity and glucose homeostasis were more evident in participants following a plant-based diet compared with other commonly used diets, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F.(22)

c. Heart diseases
c.1.The chemical compound Beta-Sitosterol is found effectively in reducing the bad cholesterol and leaving the good cholesterol untouched by inhibiting the amount our body can absorb, thus reducing the risk of plague building up in the arterial walls, leading to heart diseases, according to the study of "The Effect of Beta Sitosterol on the Serum Lipids of Young Men with Arteriosclerotic Heart Disease" by JOHN W. FARQUHAR M.D.; RALPH E. SMITH M.D.; MARY E. DEMPSEY M.S., posted in Circulation(23)

c.2. It also reduce the risk of autoimmune diseases such as multiple sclerosis, according to the study of "Effect of vitamin D and β-sitosterol on immunefunction of macrophages" by Alappat L, Valerio M, Awad AB.(24)

2. Salmon is the common name for Salmonidae. They are anadromous, born in fresh water, migrate to the ocean, then travel thousands of miles in the deep sea cold water throughout their life cycle and within to five years returning to the exacted location where they were born to reproduce and die.
a. Triacylglycerols
In the investigation of Intake of fish and omega-3 (n-3) fatty acids is associated with a reduced concentration of plasma triacylglycerols (TAG) found that intake of cod or salmon when compared with the control group. In conclusion, both lean and fatty fish may lower TAG, possibly by reducing the 18:1n-9/18:0 ratio related to allosteric inhibition of SCD1 activity, rather than by influencing the synthesis of enzyme protein, according to "Daily Intake of Cod or Salmon for 2 Weeks Decreases the 18:1n-9/18:0 Ratio and Serum Triacylglycerols in Healthy Subjects" by Telle-Hansen VH, Larsen LN, Høstmark AT, Molin M, Dahl L, Almendingen K, Ulven SM.(25)

b. Weight loss
In the investigation of supplementation with n3 long-chain polyunsaturated fatty acids (n3-LCPUFA) and its effect in body weight, found that At the end of the 1-month period, 16 children lost weight and 27 children gained weight. Multiple analysis demonstrated that supplementation with n3-LCPUFA decreased HOMA-IR by 15% after adjusting for puberty, treatment adherence, changes in adipokines, and weight loss. Interaction between supplementation and weight loss was significant (p = 0.007), according to "Supplementation of n3 Long-chain Polyunsaturated Fatty Acid Synergistically Decreases Insulin Resistance with Weight Loss of Obese Prepubertal and Pubertal Children" by López-Alarcón M, Martínez-Coronado A, Velarde-Castro O, Rendón-Macías E, Fernández J.(26)

c. Cholesterol
In the assessment of an increasing drive to replace fish oil (FO) in finfish aquaculture diets with vegetable oils (VO), driven by the short supply of FO derived from wild fish stocks,
found that these effects are most likely mediated by SREBP2, which responds to reductions in dietary cholesterol. These changes are sufficient to maintain whole body cholesterol levels but not HUFA levels, according to "Functional genomics reveals increases in cholesterol biosynthetic genes and highly unsaturated fatty acid biosynthesis after dietary substitution of fish oil with vegetable oils in Atlantic salmon (Salmo salar)" by Leaver MJ, Villeneuve LA, Obach A, Jensen L, Bron JE, Tocher DR, Taggart JB.(27)

d. Coronary heart disease
In determination of Omega-3-fatty acids play a protective role in the prevention of CHD,
found that The treatment with salmon oil led to a decrease of triglycerides in patients with hypertriglyceridemia and to an increase of cholesterol in hypercholesterolemia. Following the increase of malondialdehyde as measure of the lipid peroxidation a substitution of antioxidants, like vitamin E and vitamin C, seems to be useful. Further investigations are necessary before wide use of fish-oil capsules, not least to avoid side-effects, according to "[Changes in parameters of lipid metabolism and anti-oxidative potentials in elderly hyperlipoproteinemic patients treated with omega-3 fatty acids].[Article in German]" by Reuter W, Vorberg B, Sauer I, Krumpolt C.(28)

e. Antioxidants
In the research of the antioxidant effect of vitamin E after ingestion of salmon found that that megadoses of vitamin E, far from having pro-oxidative activity, actually increase the anti-oxidative capacity of the liver, especially after ingestion of salmon oil, according to "Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil" by Flader D, Brandsch C, Hirche F, Eder K.(29)

3. Soy sauce is a seasoning produced by fermenting soybeans and filamentous fungus, along with water and salt after a period of sometime, it yields a moromi or thick mash of cereal to obtain soy sauce by pressing it to liquid form. Tamari is made by collecting the liquid which was pressed and the liquid drained drains from miso after a certain time of fermentation.
a. Cardiovascular health
In the investigation of dietary proteins and their effect in heart diseases found that a direct cholesterol lowering effect of proteins has not been shown. Despite earlier research indicating that soy protein has cardioprotective effects as compared to other proteins, these observations have not been confirmed by randomized placebo-controlled trials. However, most experts recommend the consumption offoods rich in plant proteins as alternatives to meat and dairy products rich in saturated fat and containing cholesterol, according to "Dietary proteins and atherosclerosis" by Darioli R.(30)

b. Hypolipidemic effect
In the observation of Soy sauce (Shoyu), a traditional Japanese fermented seasoning and its effect on cholesterol level found that in a 4-week randomized, double-blind, placebo-controlled parallel group study, hyperlipidemic men (TG >150 mg/dl) were treated with 600 mg of SPS (n=15) or placebo (n=15) daily. After 4 weeks, serum TG levels in the SPS-treated group were significantly (P<0.05) lower than the baseline (0 week). In conclusion, SPS of soy sauce reduce lipid absorption, and soy sauce is a potentially promising seasoning for the treatment of hyperlipidemia through food, according to "Hypolipidemic effect of Shoyupolysaccharides from soy sauce in animals and humans" by Kobayashi M, Magishi N, Matsushita H, Hashimoto T, Fujimoto M, Suzuki M, Tsuji K, Saito M, Inoue E, Yoshikawa Y, Matsuura T.(31)

4. Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house.
a. Cardiovascular diseases
In the review of patents and products within the context of lycopene and CVD prevention and health claims indicated that in vitro data and results from animal experiments partly showed promising preventive mechanisms of lycopene. In contrast, until now, human intervention studies mostly failed to show any CVD prevention. However, there is still an encouraging situation, giving hints for antioxidant as well as anti-inflammatory effects of lycopene. These mechanisms could be the background for cardio-protective effects of tomatoes and tomato products, according to "Lycopene and heart health" by Böhm V.(32)

b. Antioxidative and Cancer Cell-Inhibiting Activities
In the research of Tomato ( Solanum lycopersicum ) plants synthesize nutrients, pigments, and bioactive compounds and their benefit in nutrition and human health found that Tomato extracts promoted growth in normal liver (Chang) cells, had little effect in normal lung (Hel299) cells, mildly inhibited growth of lung cancer (A549) cells, and first promoted and then, at higher concentrations, inhibited growth in lymphoma (U937) cells. The relationship of cell growth to measured constituents was not apparent, according to "Free Amino Acid and Phenolic Contents and Antioxidative and Cancer Cell-Inhibiting Activities of Extracts of 11 Greenhouse-Grown Tomato Varieties and 13 Tomato-Based Foods" by Choi SH, Kim HR, Kim HJ, Lee IS, Kozukue N, Levin CE, Friedman M.(33).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(21) http://www.ncbi.nlm.nih.gov/pubmed/12569114
(22) http://www.ncbi.nlm.nih.gov/pubmed/20713332
(23) http://www.ncbi.nlm.nih.gov/pubmed/20728596
(24) http://www.ncbi.nlm.nih.gov/pubmed/20728596
(25) http://www.ncbi.nlm.nih.gov/pubmed/22139893
(26) http://www.ncbi.nlm.nih.gov/pubmed/22136960
(27) http://www.ncbi.nlm.nih.gov/pubmed/18577222
(28) http://www.ncbi.nlm.nih.gov/pubmed/8091840
(29) http://www.ncbi.nlm.nih.gov/pubmed/12951900
(30) http://www.ncbi.nlm.nih.gov/pubmed/22139566
(31) http://www.ncbi.nlm.nih.gov/pubmed/18813866
(32) http://www.ncbi.nlm.nih.gov/pubmed/22076972
(33) http://www.ncbi.nlm.nih.gov/pubmed/22070764

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: TCM recommended Foods for Spleen Yang deficiency - Ginger root

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

Management and Treatment according to Traditional Chinese Medicine Perspective

While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.

Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Spleen yang deficiency

Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....

Foods for Spleen yang deficiency

Spleen yang deficiency can be managed and treated in part with a diet of fresh and cooked warming foods.

2. Ginger(1616) (See kidney yin deficiency for more information)
Jiang is also known as Ginger root. The acrid and warm herb has been use in TCM as an anti inflammation(1618)(1619)(1620), anti coagulation of platelets(1621)and anti thrombotic(1622), anti allergy(1625)(1626), anti tumors(1627)(1628) and anti hair growth(1629)(1630) lower back painpain(1623)(1624), functional bowel disorders (FBD(1631), etc., as it warms the middle burner and lungs, rescues yang, transforms phlegm by enhancing the functions of lung, spleen and stomach channels(1617).

Chemical constituents
1. 2-heptanol
2. 1,3,3-trimethyltricyclo[2,2,1,0] heptane
3. Tricycline
4. β-fenchene
5. β-pinene
6. 5-hepten-2-one-6-mehtyl
7. Myrcene
8. Octanal
9. α-thujene
10. Zingiberol
11. Zingiberene
12. α-curcumene
13. linalool
14. Cineole
15. Phellandrene
16. Camphene
17. Etc.(1617)

Strong evidences from epidemiological literature suggested that ginger also consist the properties of anti obesity(1632)(1636), anti insulin resistance(1632)01636), anti (1634)(1636), anti dyslipidaemia(1634)(1636), anti diabetes(1635)(1637) and reduced risk the metabolic syndrome causes of cardiovascular complications(1634), etc,....
Its major chemical component, [6]-gingerol analogue (6G), and extracts in rat study exhibited the protective effect against the development of metabolicsyndrome(1633)(1636), through significantly reduced body weight gain(1633)(1636), fat accumulation(1633)(1636), and circulating levels of insulin(1636)(1633) and leptin(1633).
Through its warm in nature and effects on metabolic syndrome, ginger is recommended to the daily diet of PCOs' women diagnosed with kidney yang deficiency by traditional Chinese medicine.

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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)
(1616) Chinese Herbs – Jiang (Rhizoma zingiberis officinalis) by Kyle J. Norton
(1617) Jiang(Complementary and Alternative Healing University)
(1618) Influence of ginger and cinnamon intake on inflammation and muscle soreness endued by exercise in Iranian female athletes by Mashhadi NS1, Ghiasvand R, Askari G, Feizi A, Hariri M, Darvishi L, Barani A, Taghiyar M, Shiranian A, Hajishafiee M.(PubMed)
(1619) Dietary influence on pain via the immune system by Totsch SK1, Waite ME1, Sorge RE2.(PubMed)
(1620) Anti-inflammatory effects of zingiber officinale in type 2 diabetic patients by Mahluji S1, Ostadrahimi A, Mobasseri M, Ebrahimzade Attari V, Payahoo L.(PubMed)
(1621) Anticoagulant activity of select dietary supplements by Stanger MJ1, Thompson LA, Young AJ, Lieberman HR.(PubMed)
(1622) Antithrombotic effects of naturally derived products on coagulation and platelet function by Mousa SA1.(PubMed)
(1623) The effectiveness of Swedish massage with aromatic ginger oil in treating chronic low back pain in older adults: a randomized controlled trial by Sritoomma N1, Moyle W2, Cooke M3, O'Dwyer S4.(PubMed)
(1624) Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain by Chrubasik JE1, Roufogalis BD, Chrubasik S.(PubMed)
(1625) In vitro and in vivo anti-allergic effects of 'benifuuki' green tea containing O-methylated catechin and ginger extract enhancement by Maeda-Yamamoto M1, Ema K, Shibuichi I.(PubMed)
(1626) Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation by Ahui ML1, Champy P, Ramadan A, Pham Van L, Araujo L, Brou André K, Diem S, Damotte D, Kati-Coulibaly S, Offoumou MA, Dy M, Thieblemont N, Herbelin A.(PubMed)
( 1627) Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats by Habib SH1, Makpol S, Abdul Hamid NA, Das S, Ngah WZ, Yusof YA.(PubMed)
(1628) Chemopreventive efficacy of ginger (Zingiber officinale) in ethionine induced rat hepatocarcinogenesis by Yusof YA1, Ahmad N, Das S, Sulaiman S, Murad NA.(PubMed)
(1629) 6-Gingerol inhibits hair shaft growth in cultured human hair follicles and modulates hair growth in mice by Miao Y1, Sun Y, Wang W, Du B, Xiao SE, Hu Y, Hu Z.(PubMed)
(1630) [Inhibition effect of 6-gingerol on hair growth].[Article in Chinese] by Miao Y, Sun YB, Wang WJ, Zhang ZD, Jiang JD, Li ZH, Hu ZQ.(PubMed)
(1631) Complementary and alternative medicine use and cost in functional bowel disorders: a six month prospective study in a large HMO by van Tilburg MA1, Palsson OS, Levy RL, Feld AD, Turner MJ, Drossman DA, Whitehead WE.(PubMed)
(1632) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals by Aggarwal BB1.(PubMed)
(1633) Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet by Okamoto M1, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I.(PubMed)
(1634) Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats by Madkor HR1, Mansour SW, Ramadan G.(PubMed)
(1635) Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats by Islam MS1, Choi H.(PubMed)
(1636) Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats by Nammi S1, Sreemantula S, Roufogalis BD.(PubMed)
(1637) The anti-oxidant effects of ginger and cinnamon on spermatogenesis dys-function of diabetes rats by Khaki A1, Khaki AA1, Hajhosseini L2, Golzar FS1, Ainehchi N1(PubMed)

Most Common Diseases of 50plus: Thyroid disease: Hypothyroidism – The Diet

Thyroid disease

Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.

Hypothyroidism

Hypothyroidism is a condition in which the thyroid gland is under active and produces very little thyroid hormones.

The Prevention

Diet to prevent Hypothyroidism
1. Seaweed, kelp or laver, seafood and seawater fish
According to the study by the University of Hong Kong, in the study carried out to analyse the urine iodine excretion in Hong Kong, a coastal city in the southern part of China because of a high incidence of transient neonatal hypothyroidism and a relatively high mean cord blood thyrotropin (TSH) concentration, found that 5.3% of the children, 51.7% of the adults and 55.3% of the elderly had urine iodine concentration below the criteria for iodine sufficiency (< 0.79 mumol/l). Iodine content in the drinking water and salt was low. A dietary survey revealed that seafood was not commonly consumed. 50-80% of the subjects never consumed high-iodine containing food such as seaweed, kelp or laver, and only 50% consumed seawater fish daily(47).

2. Iodized salt
In the study of Eearly morning urine collected from healthy volunteers including children (n = 104), adults (n = 112) and elderly subjects (n = 349) with a semi-quantitative questionnaire survey on the pattern of food intake was conducted in the adults and elderly, found that 45.3% of the children, 51.7% of the adults and 55.3% of the elderly had urine iodine concentration below the criteria for iodine sufficiency (< 0.79 mumol/l). Iodine content in the drinking water and salt was low(48).

3. Soy and seaweed
In the study to evaluate the relevant literature and provide the clinician guidance for advising their patients about the effects of soy on thyroid function, showed that soy foods, by inhibiting absorption, may increase the dose of thyroid hormone required by hypothyroid patients. However, hypothyroid adults need not avoid soy foods. In addition, there remains a theoretical concern based on in vitro and animal data that in individuals with compromised thyroid function and/or whose iodine intake is marginal soy foods may increase risk of developing clinical hypothyroidism(49a). Others suggested that Seaweed ingestion increased I/C concentrations (P < .0001) and serum TSH (P < .0001) (1.69 +/- 0.22 vs. 2.19 +/- 0.22 microU/mL, mean +/- SE). Soy supplementation did not affect thyroid end points. Seven weeks of 5 g/day seaweed supplementation was associated with a small but statistically significant increase in TSH. Soy protein isolate supplementation was not associated with changes in serum thyroid hormone concentrations(49).

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/17933284
(47) http://www.ncbi.nlm.nih.gov/pubmed/8863020
(48) http://www.ncbi.nlm.nih.gov/pubmed/8863020
(49a) http://www.ncbi.nlm.nih.gov/pubmed/16571087
(49) http://www.ncbi.nlm.nih.gov/pubmed/17472472