Medical Advisor Journals

Tuesday, July 19, 2016

Most Common Diseases of 50plus: Thyroid disease: Thyroid adenoma Prevention - The Antioxidants

Thyroid disease

Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.

Thyroid adenoma

Thyroid adenoma is a benign tumor started in the layer of cell lined the inner surface of the thyroid gland. The disease are relatively common among adults living in the United States. According to the study by the Mayo Clinic and Mayo Foundation, there is a report of 4 patients described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. Most thyroid nodules are Thyroid adenoma.

The Prevention

Antioxidants to prevent thyroid adenoma
1. Alpha-lipoic acid (ALA)
Patients with metastatic thyroid cancers that do not uptake iodine need effective therapeutic option. Differentiation-inducing agents have been tried to restore functional expression of sodium iodide symporter (NIS) without success. ALA is a potential agent to increase NIS transcription in TPC-1. It could be used as an adjunctive agent to increase efficacy of radioiodine therapy if combined with a strategy to increase NIS protein trafficking to cell membrane, according to the study by the University of Ulsan College of Medicine(35).

2. Selenium
According to the study by the Cancer Registry of Norway, early case-control and intervention studies suggested that selenium (Se) species might reduce the risk of cancer and in a pre-diagnostic case-control study from 1986 [1] we found that the higher the serum Se concentration, the lower was the odds ratio of thyroid cancer. Our data showed, however, that this observation occurred late in the pre-diagnostic period indicating that low serum Se was simply a consequence of thyroid cancer(36).

3. Vitamin D
The association between vitamin D and thyroid cancer is unclear. It is unknown if CYP27A1 or CYP2R1 are present in normal thyroid or cancer cells and there is limited information regarding response to treatment with vitamin D.According to the study by the, vitamin D(3), 25(OH)D(3) and 1,25(OH)(2)D(3) all had an antiproliferative effect on two thyroid cancer cell lines(37).

4. Vitamin E and coenzyme Q
In the study to clarify the different roles of free radical scavenging systems in various thyroid disorders, we measured the levels of alpha-, beta-, and gamma-tocopherols and coenzyme Q in the thyroid tissues of patients with thyroid tumors and Graves’ disease using high-performance liquid chromatography, found that the level of coenzyme Q was reduced in the thyroid tissue of patients with Graves’ disease and follicular and papillary thyroid carcinomas. These findings imply that vitamin E and coenzyme Q as scavengers play some role in thyroid follicular cell hyperfunction or dysfunction(38).

Sources
(34) http://www.ncbi.nlm.nih.gov/pubmed/11815400
(35) http://www.ncbi.nlm.nih.gov/pubmed/22995901
(36) http://www.ncbi.nlm.nih.gov/pubmed/22664335
(37) http://www.ncbi.nlm.nih.gov/pubmed/22992568
(38) http://www.ncbi.nlm.nih.gov/pubmed/9537635

The Best Obese - Weight Loss and Healthy Lunch Box recipe: Beet and feta

The Lunch Box recipes , Packed with fun, healthy meals that keep them smiling, by Kate McMillan and Sarah Putman Clegg, published by Weldonowen.

Stealth side salad: Chunky salad perfect for youngsters who have never to let a shred of lettuce pass their lips

In a small container with tight-fitting lid, combine 1 tablespoon each olive oil and orange juice and 2 teaspoon balsamic vinegar. Peel and cube 2 roasted beets. Add to the container, cover and shake. Add shredded carrot along with (or in place of) the beets. Sprinkle with feta cheese and season with salt and pepper.

Monday, July 18, 2016

Herbal therapy: Popular Herbal Myrrh (Commiphora molmol)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Herbal Myrrh (Commiphora molmol)

Myrrh in this case, is resin made from dried tree sap of Commiphora molmol, which is the genus Commiphora, belonging to the family Burseraceae, native to Somalia, Arabian Peninsula and Ethiopia. The herb has been used in traditional medicine to relieve pain and treat bruises, rheumatoid arthritis, tumors in the uterus, hemorrhoid, cataract, amenorrhea , bone and muscle ache, angina pectoris, etc.

Health Benefits
1. Anti-inflammatory and wound healing activities
In the investigation of Myrrh (Commiphora molmol) effects on anti-inflammatory and wound healing activities found that Treatment with myrrh also induced an initial increase in WBC levels that persisted through the post-injury healing period. Levels of most cell types only increased in the Group 2 and 4 rats once the injury was induced, but then declined over the healing period. Since myrrh enhanced WBC levels before injury, we conclude that myrrh likely contains substances that could induce an apparent antigen-driven response. As the myrrh also helped maintain elevated WBC levels throughout the healing period, this implied it was also able to induce maturation/differentiation/activation of both myeloid and lymphoid cell types during the effector phase of the immune responses involved in wound healing, according to "Effect of myrrh (Commiphora molmol) on leukocyte levels before and during healing from gastric ulcer or skin injury" by Haffor AS.(1)

2. Anti-coccidial effect
In the investigation of the effect of oleo-gum-resin of Commiphora monlmol Engler (Family: Burceraceae) known as Myrrh and the commercial extract known as Mirazid as a treatment against hepatic coccidiosis, found that histopathological examination of liver showed remarkable improvement in all histopathological parameters in G5 and G8 compared with the infected untreated G2. These included an almost complete healing of the hemorrhagic tissue and partial healing of the endothelial lining and hepatocytes encircling the central vein, the hepatocytes laminate regained their original radial shape and disappearance of fat vacuoles from the tissue and remarkable reduction in lymphocytes infiltration, decreased hyperplasia of the epithelial cells with significant decreasing of the parasite stage numbers, according to "Anti-coccidial effect of Commiphora molmol in the domestic rabbit (Oryctolagus cuniculus domesticus L.)" by Baghdadi HB, Al-Mathal EM.(2)

3. Liver cancer
In the assessment of the potential chemopreventive effects of myrrh (Commiphora molmol) vs. turmeric (Curcuma longa) in hepatocarcinogenic rats found that Both turmeric and myrrh induced significant biochemical and histological changes in non-treated rats. In conclusion, DENA significantly changes the biological enzymatic activities in serum and the integrity of hepatic tissues. Phytochemicals with potential hepatoprotective effects must be applied cautiously owing to their potential hepatotoxicity, according to "Potential chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis in rats: Myrrh(Commiphora molmol) vs. turmeric (Curcuma longa)" by El-Shahat M, El-Abd S, Alkafafy M, El-Khatib G.(3)

4. Antioxidants and immune effects
In the assessment of the possible role of Commiphora molmol emulsion (CME) in protecting against lead (PbAc)-induced hepatotoxicity, oxidative stress and immunotoxicity in rabbits found that pretreatment with CME attenuated these adverse effects in a dose-dependent protection. CME, therefore, is a potent antioxidant, and can protect against PbAc-induced hepatic oxidative damage and immunotoxicity by reducing lipid peroxidation and enhancing the antioxidant and immune defense mechanisms, according to "Oxidative stress and immunotoxic effects of lead and their amelioration with myrrh (Commiphora molmol) emulsion" by Ashry KM, El-Sayed YS, Khamiss RM, El-Ashmawy IM.(4)

5. Vaginal trichomoniasis
In the determination of treatment of patients with metronidazole refractory vaginal trichomoniasis of patient who are still resistant to the combined treatment were given Commiphora molmol (Myrrh) as two capsules for six to eight successive days on an empty stomach two hours before breakfast, found that natural plant extract purified from (Roman) was in-vitro investigated for its efficacy against T. vaginalis on fresh Diamond media. The anti-trichomoniasis vaginalis activity of both P. granatum (in-vitro) and C. molmol (in-vivo) extracts gave promising results, according to "Efficacy of two plant extracts against vaginal trichomoniasis" by El-Sherbini GT, El Gozamy BR, Abdel-Hady NM, Morsy TA.(5)

6. Hepatotoxic, genotoxic and carcinogenic effects
In the determination of the natural myrrh extract Mirazid and its potential carcinogenicity and genotoxicity found that on comparing both drugs, praziquantel induced a significant hepatotoxic, genotoxic and carcinogenic effects. It was concluded that, Praziquantel is considered to be a hepatotoxic, genotoxic and carcinogenic drug. On the other hand, Mirazid seemed to be a safe and promising antiparasitic drug, free from hepatotoxic, genotoxic and carcinogenic effects, according to "Comparative study of the hepatotoxic, genotoxic and carcinogenic effects of praziquantel distocide & the natural myrrh extract Mirazid on adult male albino rats" by Omar A, Elmesallamy Gel-S, Eassa S.(6)

7. Antibacterial and antifungal properties
In the observation of the extracted, purified and characterized 8 sesquiterpene fractions from Commyphora molmol found that a mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, which showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 micrograms/ml, according to "Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes frommyrrh" by Dolara P, Corte B, Ghelardini C, Pugliese AM, Cerbai E, Menichetti S, Lo Nostro A.(7)

8. Anti diabetes
In the investigation of a blood glucose lowering extract of a mixture of five plants in use by Kuwaiti diabetics found that only the extracts of myrrh and aloe gums effectively increased glucose tolerance in both normal and diabetic rats, according to "Studies on the activity of individual plants of an antidiabetic plant mixture" by Al-Awadi FM, Gumaa KA.(8)

9. Etc.

Side effects
1. Do not use the herb in children or if you are pregnant or breast feeding without approval from the related field specialist.
2. Myrrh may cause irritation of the eyes and mucous membranes, if it is contacted.
3. Overdoses may cause gastrointestinal discomfort.
4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19995243
(2) http://www.mendeley.com/research/anticoccidial-effect-commiphora-molmol-domestic-rabbit-oryctolagus-cuniculus-domesticus-l/
(3) http://www.ncbi.nlm.nih.gov/pubmed/21871653
(4) http://www.ncbi.nlm.nih.gov/pubmed/19818824
(5) http://www.ncbi.nlm.nih.gov/pubmed/19530609
(6) http://www.ncbi.nlm.nih.gov/pubmed/15881015
(7) http://www.ncbi.nlm.nih.gov/pubmed/10865454
(8) http://www.ncbi.nlm.nih.gov/pubmed/3618079

Phytochemicals in Foods - The Effects of Ferulic acid

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Ferulic acid

Ferulic acid is a phytochemical in the class of Hydroxycinnamic acids, found abundantly in cinnamon, aloe. etc.

Health Benefits
1. Skin Photoprotection
In the examination of the effects of a topical antioxidant mixture consisting of vitamin C, ferulic acid, and phloretin on attenuating the harmful effects of UV irradiation on normal healthy volunteers were studied using biomarkers of skin damage, found that the protective role of a unique mixture of antioxidants containing vitamin C, ferulic acid, and phloretin on human skin from the harmful effects of UV irradiation. Phloretin, in addition to being a potent antioxidant, may stabilize and increase the skin availability of topically applied vitamin C and ferulic acid. We propose that antioxidant mixture will complement and synergize with sunscreens in providing photoprotection for human skin, according to "Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin" by Oresajo C, Stephens T, Hino PD, Law RM, Yatskayer M, Foltis P, Pillai S, Pinnell SR.(1)

2. Hearing loss
In the examination of the effect of ferulic acid (FA), a phenolic compound and their effect of noise-induced hearing loss, found that FA-induced improvement of auditory function was counteracted by the HO inhibitor zinc-protoporphyrin-IX and paralleled the time-course of HO-1 induction over 3-7 days. These results confirm the antioxidant properties of FA as free-radical scavenger and suggest a role of HO-1 as an additional mediator against noise-induced ototoxicity, according to "In vivo protective effect of ferulic acid against noise-induced hearing loss in the guinea-pig" by Fetoni AR, Mancuso C, Eramo SL, Ralli M, Piacentini R, Barone E, Paludetti G, Troiani D(2)

3. Antioxidant effects
In the examination of both qualitative and quantitative analyses of the major phenolic compounds in barley and flaxseed hulls were conducted using reverse phase high-performance liquid chromatography coupled with photodiode array detection and quadrupole time-of-flight mass spectrometry found that Ferulic acid, p-coumaric acid, vanillic acid and vanillin were identified and quantified in four barley hull samples. Four ferulate dehydrodimers were also detected. The phenolic compounds of flaxseed hull were distinct from those of barley hull. Three flaxseed hull samples varied significantly (P < 0.05) in their contents of secoisolariciresinol diglucoside (16.38-33.92 g kg(-1) ), coumaric acid glucoside (35.68-49.22 g kg(-1) ) and ferulic acid glucoside (5.07-15.23 g kg(-1) ) and barley and flaxseed hulls may be utilised as potential sources of functional food ingredients through extraction and concentration of the phytochemicals identified above, according to "Qualitative and quantitative analysis of the major phenolic compounds as antioxidants in barley and flaxseed hulls using HPLC/MS/MS" by Hao M, Beta T.(3)

4. Antidepressant-like effect
In the verification of the possible antidepressant-like effect of acute oral administration of ferulic acid in the forced swimming test (FST) and tail suspension test (TST) in mice, found that the combination of fluoxetine (5mg/kg, p.o.), paroxetine (0.1mg/kg, p.o.) or sertraline (1mg/kg, p.o.) with a sub-effective dose offerulic acid (0.001mg/kg, p.o.) produced a synergistic antidepressant-like effect in the TST, without causing hyperlocomotion in the open-field test. Taken together, these results demonstrate that ferulic acid exerts antidepressant-like effect in the FST and TST in mice through modulation of the serotonergic system, according to "Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: Evidence for the involvement of the serotonergic system" by Zeni AL, Zomkowski AD, Maraschin M, Rodrigues AL, Tasca CI.(4)

5. Anti-aging effects
In the evaluation of the anti-aging effects of the gel and cream containing niosomes entrapped with the rice bran bioactive compounds. The semi-purified rice bran extracts containing F, O, and P which indicated the growth stimulation of human fibroblasts and the inhibition of MMP-2 by sulforhodamine B and gelatin zymography, respectively, were entrapped in niosomes by supercritical carbon dioxide fluid (scCO(2)) and incorporated in gel and cream formulations.
found that these formulations also demonstrated higher hydration enhancement and improvement of skin lightening, thickness, roughness, and elasticity on the skin of 30 human volunteers within the 28-day treatment not more than 9, 27, 7, 3, and 3 times, respectively. Discussion and conclusions: The formulations containing niosomes entrapped with the rice bran bioactive compounds gave superior clinical anti-aging activity which can be applied as a novel skin product, according to "Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds" by Manosroi A, Chutoprapat R, Abe M, Manosroi W, Manosroi J.(5)

6. Neuroprotective effect
In the investigation of whether ferulic acid demonstration of neuroprotective effect through the activation of Akt and its downstream targets, Bad and 14-3-3, found that that ferulic acid attenuates cell death during MCAO and that these protective effects are due to inhibition of Akt signaling pathway inactivation and maintenance of the interaction between phospho-Bad and 14-3-3, according to "Ferulic acidprevents the cerebral ischemic injury-induced decrease of Akt and Bad phosphorylation" by Koh PO.(6)

7. Chronic kidney disease (CKD)
In the study of the effect of ferulic acid (FA) and gallic acid (GA) in treatment of chronic kidney disease (CKD), found that The inhibitory effects of FA and GA on MMP-2 were very comparable. GA suppressed MMP-2 more effectively than FA in DRCKD rats. Both FA and GA induced SOD elevation and MDA elimination. In DRCKD rats, Western blot analysis indicated that FA further up-regulated CD34, α-SMA, tissue pDGFR, p-PDGFR, and TGF-β; and down-regulated p-PI3K, and p-Akt. Since both PDGF-BB and TGF-β are considered to induce kidney prefibrosis stage, GA was proved to be more beneficial in this regard, according to "Ferulic acid is nephrodamaging while gallic acid is renal protective in long term treatment of chronic kidney disease" by Peng CC, Hsieh CL, Wang HE, Chung JY, Chen KC, Peng RY.(7)

8. Neurodegenerative disorders
In the investigation of Oxidative stress involved in the onset, progression and pathogenesis of a number of diseases including neurodegenerative diseases for the development from a pharmacological approach to combat oxidative stress which may reduce the risk of diseases and help in promoting healthy life, indicated that the protective role of ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA), a naturally occurring antioxidant compound found in fruit, some vegetables, and grains, and its ethyl ester derivative are discussed with respect to neurodegeneration. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease, according to "Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders" by Sultana R.(8)

9. Diabetes
In the investigation of ferulic acid (FA) known as anti-oxidative agent effect on diabetic nephropathy by anti-oxidative and anti-inflammatory mechanism, found that in renal histopathology, FA-treated OLETF rats showed decreased glomerular basement membrane thickness, glomerular volume, and mesangial matrix expansion. FA treatment decreased oxidative stress markers and MCP-1 levels in 24 h urine of rats and supernatants of cultured podocyte. FA have protective and therapeutic effects on diabetic nephropathy by reducing oxidative stress and inflammation, according to "Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes" by Choi R, Kim BH, Naowaboot J, Lee MY, Hyun MR, Cho EJ, Lee ES, Lee EY, Yang YC, Chung CH.(9)

10. Cytotoxic effects
In the study of the first synthesis of 1-O-feruloyl-secoisolariciresinol, 1,4-O-diferuloyl-secoisolariceresinol and their analogues and theirs cytotoxicities against several cancer cell lines,
found that the feruloyl diester derivative of secoisolariciresinol was the most active cytotoxic compound against all the cancer cells tested in this experiment. The IC(50) values of the1,4-O-diferuloyl-secoisolariceresinol were in the range of 7.1-9.8μM except one cell line. In considering that both ferulic acid and secoisolariciresinol are commonly found in many plants and have no cytotoxicity, this finding is remarkable in that simple covalent bonds between the ferulic acid and secoisolariciresinol cause a cytotoxic effect, according to "Synthesis and evaluation of cytotoxic effects of hanultarin and its derivatives" by Lee E, Ahamed VS, Kumar MS, Rhee SW, Moon SS, Hong IS.(10)

11. Etc.

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs - He Shu Wu (Radix Polygoni Multiflori)

He Shu Wu (Radix Polygoni Multiflori)

He Shu Wu or Ye Jiao Teng or Shu Wu is also known as Fleece flower root, Fo-ti.
1. The prepared herb is astringent with some sweetness, mildly warm
2. The raw herb is bitter, sweet and neutral
and they have been used in TCM to treatment of hyperlipemia, neurasthenia, split personality, premature white hair, nerve injuries, skin wind rash, etc., as the herbs tonify the Essence and Blood, benefit the Essence and Blood, expel toxins, moisten the Intestines, etc. byenhancing the (The prepared herb) liver and kidney channels and (The raw herb) liver, heart and large intestine channels.

Ingredients
1. Polygoacetophenoside
2. Chrysophanol
3. Emodin
4. Rhein
5. Emodin-6
6. Physcion
7. Chrysophanic acid
8. Anthrone
9. beta-sitosterol
10. 2,3,5,4′-tetrahydroxystibene-2O-b-D-glucoside
11. Quercetin-3-O-galactoside
12. Querctin-3-O-arabinoside
13. Lecithin
14. Etc.

Health Benefits
1. Anti-breast cancer
In the evaluation of the inhibitory effect of PM extract (PME) on the proliferation of MCF-7 cells and the underlying mechanisms showed that PME down-regulated the protein expression of Cdc25B and Cdc25C phosphatases accompanied by an increase in phospho-Cdk1, and PME promoted cytochrome c release from mitochondria into the cytosol to activate caspase-9. The present study demonstrated that PME inhibited MCF-7 cell proliferation by inducing cell cycle arrest in the G2/M phase and promoting cell apoptosis. The effects of PME on MCF-7 cells were associated with the modulation of the expression levels of proteins involved in the cell cycle and apoptosis. These data suggest that PME has promise as a treatment against breast cancer by inhibiting the proliferation of cancer cells, according to “Anti-proliferative effect of an extract of the root of Polygonum multiflorum Thunb. on MCF-7 human breast cancer cells and the possible mechanisms” by Chen HS, Liu Y, Lin LQ, Zhao JL, Zhang CP, Jin JC, Wang L, Bai MH, Wang YC, Liu M, Shen BZ(1).

2. Diabetic nephropathy
In the determination of the protective mechanisms of TSG on diabetic nephropathy of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (TSG), an active component extract from Polygonum multiflorum Thunb, indicated that the protective mechanisms of TSG on diabetic nephropathy are involved in the alleviation of oxidative stress injury and overexpression of COX-2 and TGF-β1, partially via activation of SIRT1, according to “Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway” by Li C, Cai F, Yang Y, Zhao X, Wang C, Li J, Jia Y, Tang J, Liu Q.(2).

3. Neurodegenerative diseases
In the investigation of the protective effects of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG), an active component extracted from a traditional Chinese herb Polygonum multiflorum Thunb against MPP(+)-induced apoptosis in PC12 cells and its underlying mechanism, found that incubation of PC12 cells with TSG before exposing them to MPP(+) could significantly decrease cell viability loss and reverse cell apoptosis in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated via the inhibition of ROS generation and modulation of JNK activation because TSG blocked ROS increase and JNK phosphorylation induced by MPP(+). Taken together, these results indicated that TSG may provide a useful therapeutic strategy for the treatment of neurodegenerative diseases such as PD, according to “Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation” by Li X, Li Y, Chen J, Sun J, Li X, Sun X, Kang X.(3).

4. Anti colitis
Inn the evaluation of the effects of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), an active component extracted from Polygonum multiflorum Thunb, on acetic acid-induced acute colitis and mitomycin C-induced chronic colitis, found that THSG were better than that of positive control drug, 5-aminosalicylic acid (5-ASA). In mitomycin C-induced model, THSG (60 mg/kg) administered for 7 days and 24 days, significantly improved colon damage and inhibited MPO activity and MDA content while increased SOD activity only on the 7th day and debased NO level on the 24th day. Furthermore, on the 24th day, the effects of THSG were prior to that of 5-ASA. Additionally, THSG (60 mg/kg) could inhibit iNOS expression in both models, according to “Protective effects of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice” by Wang X, Zhao L, Han T, Chen S, Wang J.(4).

5. Anti-atherosclerosis
In the evaluation of the effects of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), a compound extracted from the root of Polygonum multiflorum Thunb, on lipoprotein (LDL and VLDL) oxidation, proliferation and nitric oxide (NO) content of coronary arterial smooth cells (CASMCs) induced by LDL, VLDL, ox-LDL and ox-VLDL, found that THSG possesses the antagonistic effects on oxidation of lipoprotein, proliferation and decrease of NO content of CASMCs, which partially explain the mechanism of anti-atherosclerosis of Polygonum multiflorum Thunb, according to “Effect of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-D-glucoside on lipoprotein oxidation and proliferation of coronary arterial smooth cells” by Liu QL, Xiao JH, Ma R, Ban Y, Wang JL.(5).

6. Anti colon cancer and Cdc25B phosphatase inhibitors
In the study of “Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb” by Choi SG, Kim J, Sung ND, Son KH, Cheon HG, Kim KR, Kwon BM, found that three anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B phosphatase with IC(50) values of 62.5, 30, and 34 microg mL(-1), respectively. Emodin (2) and questin (3) strongly inhibited the growth of human colon cancer cells, SW620 with GI(50) values of 6.1 and 0.9 microg mL(-1), respectively. Commercially available anthraquinones, chrysophanol (4), and rhein (5) also inhibited Cdc25B phosphatase with IC(50) values of 10.7 and 22.1 microg mL(-1), respectively(6).

7. Etc.

Side effects
1. Do not use in cases of spleen deficient.
2. Overdose can cause liver inflammation.
3. Do not use the herb in newborn, children or if you are pregnant or breast feeding without consulting first with the related field specialist
4. There are cases of which the herb induces both bone marrow suppression and hepatotoxicity.(a) Could there be overdoses?
5. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/20479902
(1) http://www.ncbi.nlm.nih.gov/pubmed/21874249
(2) http://www.ncbi.nlm.nih.gov/pubmed/20854812
(3) http://www.ncbi.nlm.nih.gov/pubmed/20643188
(4) http://www.ncbi.nlm.nih.gov/pubmed/17963744
(5) http://www.ncbi.nlm.nih.gov/pubmed/17701557
(6) http://www.ncbi.nlm.nih.gov/pubmed/17497420

The Obesity' Research and Studies of Intake of sugar-sweetened beverages and weight gain

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of Intake of sugar-sweetened beverages and weight gain

Consumption of sugar-sweetened beverages (SSBs), particularly carbonated soft drinks, may be a key contributor to the epidemic of overweight and obesity, by virtue of these beverages' high added sugar conten. Researchers at the , Harvard School of Public Health, showed that a school-based intervention found significantly less soft-drink consumption and prevalence of obese and overweight children in the intervention group than in control subjects after 12 mo, and a recent 25-week randomized controlled trial in adolescents found further evidence linking SSB intake to body weight. The weight of epidemiologic and experimental evidence indicates that a greater consumption of SSBs is associated with weightgain and obesity. Although more research is needed, sufficient evidence exists for public health strategies to discourage consumption of sugary drinks as part of ahealthy lifestyle(1).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) " Intake of sugar-sweetened beverages and weight gain: a systematic review" by Malik VS, Schulze MB, Hu FB.

Most Common Diseases of 50plus: Thyroid disease: Thyroid adenoma Prevention - The Phytochemicals

The Prevention

Phytochemicals to prevent thyroid adenoma
1. Epigallocatechin-3-gallate (EGCG)
According to the study by the Health and Nutrition Sciences, University of Calabria, EGCG (10, 40, 60 μM) treatment inhibited the growth of FB-2 and WRO cells in a dose-dependent manner. These changes were associated with reduced cyclin D1, increased p21 and p53 expression. Furthermore, EGCG suppressed phosphorylation of AKT and ERK1/2. In addition EGCG treatment results in reduction of cell motility and migration. Changes in motility and migration in FB-2 were associated with modulation in the expression of several proteins involved in cell adhesion and reorganization of actin cytoskeleton. After 24 h EGCG caused an increase of the E-cadherin expression and a concomitant decrease of SNAIL, ZEB and the basic helix-loop-helix transcription factor TWIST. Besides expression of Vimentin, N-cadherin and α5-integrin was down-regulated(31). Other study indicated that EGCG treatment inhibited the growth of ARO cells in a dose-dependent manner. Furthermore, EGCG suppressed phosphorylation of EGFR, ERK1/2, JNK, and p38. These changes were associated with increased p21 and reduced cyclin B1/CDK1 expression. In addition, EGCG treatment increased the accumulation of sub-G1 cell, activated caspase-3 and cleaved PARP(32).

2. Isoflavone derivatives
Antiproliferative effect of cD-tBoc on these cells is mediated through ERβ. Furthermore, cD-tBoc potently increased apoptosis and cell necrosis. Co-incubation with the antiapoptotic agent Z-VAD-FMK reversed the growth inhibitory effect elicited by cD-tBoc. These results support the hypothesis that estrogens are involved in the proliferation of MTC. The potent anti-proliferative effects mediated by isoflavone derivatives in the human MTC cell line TT suggest and that this property may be utilized to design effective anti-neoplastic agents, according to study by the Tel-Aviv University(33).

3. Phytoestrogens
Epidemiological and pathological data suggest that thyroid cancer may well be an estrogen-dependent disease. In the study of the relationship between thyroid cancer risk and dietary phytoestrogens, which can have both estrogenic and antiestrogenic properties, using the present data from a multiethnic population-based case-control study of thyroid cancer conducted in the San Francisco Bay Area. Of 817 cases diagnosed between 1995 and 1998 (1992 and 1998 for Asian women), 608 (74%). Of 793 controls identified through random-digit dialing, 558 (70%) indicated that phytoestrogen consumption was assessed via a food-frequency questionnaire and a newly developed nutrient database. The consumption of traditional and nontraditional soy-based foods and alfalfa sprouts were associated with reduced risk of thyroid cancer. Consumption of “western” foods with added soy flour or soy protein did not affect risk. Of the seven specific phytoestrogenic compounds examined, the isoflavones, daidzein and genistein [odds ratio (OR), 0.70; 95% confidence interval (CI), 0.44-1.1; and OR, 0.65, 95% CI, 0.41-1.0, for the highest versus lowest quintile of daidzein and genistein, respectively] and the lignan, secoisolariciresinol (OR, 0.56; 95% CI, 0.35-0.89, for the highest versus lowest quintile) were most strongly associated with risk reduction. Findings were similar for white and Asian women and for pre- and postmenopausal women. Our findings suggest that thyroid cancer prevention via dietary modification of soy and/or phytoestrogen intake in other forms may be possible but warrants further research at this time(34).