Medical Advisor Journals

Wednesday, August 10, 2016

Herbal therapy: Popular Herbal Rhubarb

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Herbal Rhubarb

Rhubarb is a small flower grouped with large compound leafy in the the genusRheum, belonging to the family Polygonaceae. The herb has been used in traditional medicine as laxative agent, reduce inflammation and treat diarrhea, dysentery blood clots, tumor red and painful eyes abdominal-distention and/or pain blood in stool hemorrhoidal bleeding urination: burning sensation, absence of menses, etc.

Health Benefits
1. Cardiovascular diseases
In the elavuation of piceatannol-3'-O-beta-D-glucopyranoside (PG), a potent component of stilbenes and theirs inhibited activity of arginase I and II prepared, found that PG showed IC((50)) value of 11.22 microM and 11.06 microM against arginase I and II, respectively. PG as an arginase inhibitor, therefore, represents a novel molecule for the therapy of cardiovascular diseases derived from endothelial dysfunction and may be used for the design of pharmaceutical compounds, according to 'Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity" by Woo A, Min B, Ryoo S.(1)

2. Anti-cancers
In the investigation of the toxicological and anti-neoplastic potentials of the main anthraquinones from Rhubarb, Rheum palmatum, found that Rhein is the other major rhubarb anthraquinone, although less well studied. This compound could effectively inhibit the uptake of glucose in tumor cells, caused changes in membrane-associated functions and led to cell death. Interestingly, all three majorrhubarb anthraquinones were reported to have in vitro phototoxic. This re-evaluation of an old remedy suggests that several bioactive anthraquinones ofrhubarb possess promising anti-cancer properties and could have a broad therapeutic potential, according to "Anti-cancer properties of anthraquinones from rhubarb" by Huang Q, Lu G, Shen HM, Chung MC, Ong CN.(2)

3. Breast cancer
In the investigation of antiproliferation effects of anthraquinone derivatives ofrhubarb root on human breast cancer cells, found that rhein is processing anti-proliferative activity against HER2 overexpression or HER2-basal expression in breast cancer cells and playing important roles in apoptotic induction of human breast cancer cells, according to "Rhein induces apoptosis in human breast cancer cells" by Chang CY, Chan HL, Lin HY, Way TD, Kao MC, Song MZ, Lin YJ, Lin CW.(3)

4. Gastrointestinal protection against severe burn
In the identification of the influence of rhubarb in patients with severe burn, found that Rhubarb can protect intestinal mucosal barrier in patients with severe burn through increasing secretion of gastrointestinal hormones and promoting restoration of gastrointestinal motility, according to " [Influence of rhubarb on gastrointestinal motility and intestinal mucosal barrier in patients with severe burn].[Article in Chinese]" by Meng YB, Lei J, Hao ZM, Cao RL.(4)

5. Cirrhotic ascites
In the study of the efficacy of investigate the efficacy of Xiaozhang Tie, a traditional Chinese herbal cataplasm, including Rhubarb in patients with cirrhotic ascites, found that Xiaozhang Tie as an adjuvant to primary therapy of cirrhotic ascites is safe and shows a remarkable efficacy on relieving abdominal distention, according to 'Effects of Chinese herbal cataplasm Xiaozhang Tie on cirrhotic ascites" by Xing F, Tan Y, Yan GJ, Zhang JJ, Shi ZH, Tan SZ, Feng NP, Liu CH.(5)

6. Obesity
In the evaluation of the effects of the traditional Korean anti-obesity drug GGEx18, a mixture of three herbs, Laminaria japonica Aresch (Laminariaceae), Rheumpalmatum L. (Polygonaceae), found that GGEx18 inhibited lipid accumulation, and similar activation of genes was observed in GGEx18-treated C2C12 cells. However, compound C inhibited these effects in C2C12 cells. Discussion and conclusion: These results suggest that GGEx18 improves obesity through skeletal muscle AMPK and AMPK-stimulated expression of PPARα and its target enzymes for fatty acid oxidation, according to "The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα" by Shin SS, Park D, Lee HY, Hong Y, Choi J, Oh J, Lee H, Lee HR, Kim MR, Shen ZB, Cui HH, Yoon M.(6)

7. Antioxidant and anti-inflammatory activities
In the observation of the antioxidant, anti-inflammatory, and cytotoxic activities of water and ethanol extracts of 14 Chinese medicinal plants, including Rheumofficinale, found that Four plants, namely, Scutellaria baicalensis , Taxillus chinensis , Rheum officinale, and Sophora japonica , showed significant antioxidant activity in both yeast model and also free radical scavenging methods, according to "Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds" by Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Smith PT, Bartlett J, Shanmugam K, Münch G, Wu MJ.(7)

8. Menopausal symptoms
In the investigation of the efficacy of ERr 731(®), a commercially available extract isolated from Rheum rhaponticum on menopausal symptoms, including hot flushes, depression, anxiety and vaginal dryness found that the observations from previous trials regarding the endometrial safety of ERr 731(®) have been supported by our experimental findings that exclude a stimulatory activity on proliferation in the uterus in a long-term administration in the young adult rat but no effect on the bone mineral density could be observed, according to "Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats" by Keiler AM, Papke A, Kretzschmar G, Zierau O, Vollmer G.(8)

9. Hepatotoxicity or hepatoprotection?
In the determination of the efficacy of Rhubarb on Hepatotoxicity or hepatoprotection, found that The curative effect of administering the two lowest dosages of RE to CCl(4)-treated rats was mainly expressed as a decrease in the extent of cellular injury. The hepatoprotective mechanism of RE might be related to its antioxidant effect, the antagonism of the free radical damage to hepatocytes caused by CCl(4). By contrast, the RE-induced liver damage was mainly expressed as a significant increase in the amount of fibrosis in both normal rats at all dosage levels and CCl(4)-treated rats at the two highest dosage levels, according to "Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury" by Wang JB, Zhao HP, Zhao YL, Jin C, Liu DJ, Kong WJ, Fang F, Zhang L, Wang HJ, Xiao XH.(9)

10. Anti diabetes
In the comparison of the Western medicine treatment group (Group A) received insulin and orally took anti-diabetic drugs, while those in the TR group (Group B) received insulin and orally took TR (consisting of astragalus, raw rehmannia root, sanchi root, euonymus branchlet, rhubarb, bitter orange, and dogwood fruit, etc. 4 g/package), found that Treatment of insulin and TR showed similar favorable effect to Western medicine in treatment of diabetic nephropathy. It could improve in vivo hypomethylation and oxidative stress, according to "[Effects of tangshen recipe on the homocysteine metabolism of patients with diabetic nephropathy].[Article in Chinese]" by Jiang ZT, Liang QL, Wang YM.(10)

11. Antimicrobial peptides
In evaluation of the correlation between rhubarb and expressions of antimicrobial peptides (AP) in the small intestine of mice found that after gastrogavaged withrhubarb decoction, changes of AP contents in the small intestine homogenate of mice were not obvious, but the molecular weights of AP were different. But the AP contents in the small intestine perfusate obviously increased, with the molecular weights being 14.3 to 18.4 kDa. But its bactericidal capacity showed no statistical difference when compared with that of the control group (P>0.05), according to "[Correlation study of rhubarb and expression changes of antimicrobial peptides in the small intestine of mice].[Article in Chinese]" by Yan ZP, Chen XL, Zhang Z.(11)

12. Etc.

Side effects
1. Do not use the herb as long-term treatment for constipation
2. Do not use the herb in children or if you are pregnant or breast feeding without approval from the related field specialist.
3. Rhubarb may interact with other medicine, including Lanoxin
4. Overdose may cause gastrointestinal discomfort, such as diarrhea or vomiting, in some case cause liver damage
5. Etc.

Men Health: Prostate cancer: The effects of Vitamin K

Prostate cancer

The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian with tendency to effect even younger age population. Suggestions emerged of over consuming bad fats in any time in history accompanied with unhealthy diet and life style may be the possible causes of the disease, linking to the economic prosperity over 2 decades. Foods for diseases' management have been prescribed in folk medicine over thousands of year as one of best medicine of nature in preventing and treating diseases, including prostate cancer.
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth with possibility of spreading to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

The effects of Vitamin K

Vitamin K(K1, phylloquinone; K2, menaquinones), is a fat soluble vitamin, found abundantly in leafy green vegetables, broccoli, and Brussels sprouts, etc. It is best known for promotion of coagulation and bone health.

Epidemiological studies focused in the synthetic version of vitamin K(Vk3) in reduced risk and treatment of prostate cancer have proven successful in certain extents. In human prostate cancer cells (DU145) implanted mice, administration of C/vitamin K(3) showed to exhibit serum alkaline DNase (DNase I) and acid DNase (DNase II) known as circulating tumour marker accompanied by a decrease in DNA expression of the tumor cells(1). Administration of vitamin C (Vit C), vitamin K3 (Vit K3), or vitamin C:vitamin K3 combinations against a prostate cancer cell line (DU145), suggest that vitamin treatment with individual vitamins affects the cytoskeleton(a series of intercellular proteins that help a cell with shape, support, and movement), the mitochondria, and other membranous components of the cell(2).
Vitamin K4 (VK4) is a synthetic version of vitamin K, inhibited proliferation in PC-3 cells with an IC50 value of about 20.94 microM, through cell cycle arrest at the S phase, disruption of the energy production in the surface of cell membrane, up regulation apoptotic and down regulation of proliferative pathways(3). Alpha-tocopheryl succinate (alpha-TOS), the redox-silent vitamin E analogue used in combination with VK3, showed to induce efficiently cell death that resembles autoschizis(cell death), through cell demise, lipid peroxidation, DNA damage, cytoskeleton alteration, lysosomal-mitochondrial perturbation, and release of cytochrome c without caspase activation(4), In a A prostate carcinoma cell line derived from the transgenic murine prostate cancer model (TRAMP), combination of of ascorbate:menadione (VC + VK(3), induced cell death by autoschizis, included cytokeletal changes conducive to cytoplasmic blebbing, self-excisions, and progressive nuclear alteration, through axidative stress(5). and the Co-administration of the vitamins also enhanced the antitumour activity 5- to 20-fold, with increased cytotoxicity through redox cycling and increased oxidative stress(6). On a human prostate carcinoma cell line (DU145), the co administration also showed to enhance cytotoxicity through increased oxidative stress, subsequent membrane damage, and DNA fragmentation (7). Menaquinones (vitamin K(2) in the study of its association with overall cancer incidence and mortality, showed to
associate with a reduced risk of incident and fatal cancer(8) including prostate cancer(9).

Taking altogether, co administration of synthetic vitamin K3 and other vitamins such as vitamin C is associated to reduced risk and treatment of prostate cancer, though cell cycle arrest, up regulation of
anti profilerative and down regulation of cancer promoter pathways or increased oxidative stress. Overdoses can induce symptoms of Skin rash, Diarrhea, Nausea, Vomiting, Anemia, etc. Please make sure you follow the guideline of the Institute of Medicine of the National Academies.

Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of Reproductive Men Health

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References
(1) In vivo reactivation of DNases in implanted human prostate tumors after administration of a vitamin C/K(3) combination by Taper HS, Jamison JM, Gilloteaux J, Gwin CA, Gordon T, Summers JL(PubMed)
(2) Scanning electron microscopy and transmission electron microscopy aspects of synergistic antitumor activity of vitamin C - vitamin K3 combinations against human prostatic carcinoma cells by Gilloteaux J, Jamison JM, Venugopal M, Giammar D, Summers JL(PubMed)
(3) Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway by Jiang Y, Yang J, Yang C, Meng F, Zhou Y, Yu B, Khan M, Yang H(PubMed)
(4) alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate by Tomasetti M, Strafella E, Staffolani S, Santarelli L, Neuzil J, Guerrieri R(PubMed)
(5) Cell death by autoschizis in TRAMP prostate carcinoma cells as a result of treatment by ascorbate: menadione combination by Gilloteaux J, Jamison JM, Neal DR, Summers JL(PubMed)
(6) Synergistic antitumour activity of vitamins C and K3 against human prostatecarcinoma cell lines by Venugopal M, Jamison JM, Gilloteaux J, Koch JA, Summers M, Hoke J, Sowick C, Summers JL.(PubMed)
(7) Flow cytometric and ultrastructural aspects of the synergistic antitumor activity of vitamin C-vitamin K3 combinations against human prostatic carcinoma cells by Jamison JM, Gilloteaux J, Venugopal M, Koch JA, Sowick C, Shah R, Summers JL(PubMed)
(8) Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancerand Nutrition (EPIC-Heidelberg) by Nimptsch K, Rohrmann S, Kaaks R, Linseisen J.(PubMed)
(9) Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg) by Nimptsch K, Rohrmann S, Linseisen J.(PubMed)

Women Health: Premenstrual syndrome(PMS): caused by Liver blood stagnation in Chinese Herbs Perspective

Premenstrual syndrome(PMS)

Premenstrual syndrome is defined as faulty function of the ovaries related to the women's menstrual cycle, effected over 70% to 90% of women in the US and lesser for women in Southeast Asia because of difference in living style and social structure. The syndrome also interferes women's physical and emotional states, and daily activities as a result of hormone fluctuation and occurs one to two weeks before menstruation and then declines when the period starts.

Caused by Liver blood stagnation in Chinese Herbs Perspective

Traditional Chinese medicine used over 4000 thousand years in treating women reproductive system disorder believed Pre menstrual syndrome is caused by

Liver blood stagnation, is a milder form of impaired blood flow(2) in the abdominal region(1) including uterus causes of menstrual pain and cramps(1)(2) before the period. By releasing the blood stagnation, in the abdomen, certain herbs have shown to relieve symptoms of PMS, including migraine(2).
1. Angelica root
Angelica root is a queen for women reproductive system, used in traditional Chinese medicine in tonifying blood, promoting blood circulation(2), regulating menstruation(1), alleviating pain(2), and lubricating the bowels to relieve constipation(3), probably through its phytochemicalsè estrogenic(12)(13) and antiestrogenic(14) activities.
Angelica root also showed a protective effect against kidney injure(5)(6), radiation(7), cancers(8)(9)(15), osteoarthritis (OA)(10) and to improve immunity(4), dementia(16), female sexual dysfunction (FSD), menopausal symptoms(17), menopausal symptoms(18), etc. in modern studies.

2. Peony (Shao Yao)
Peony has been used in Chinese medicine in treating liver(20)(22)(27) blood stagnation(19) and induced blood flow by increasing the liver in blood formation(19) and promoting circulatory system for providing nutrients to our body need to nourish menstruation(20), relaxing spasm(22), relieving pain(22) and liver dysfunction(20) causes of tension of nervous system, such as anxiety(30).

Peony also showed a protective effect against influenza(20)(21), inflammatory diseases(24)(25), diabetes(26)(28)and triglycerides accumlation(26), cancers(21)(23), and to promote would healing(29), etc.. in modern studies.

3. Spatholobus spp (Ji Xue Teng)
Spathholobus spp is a blood tonic medicine, used in TCM to treat reproductive system disorders caused by blood stagnation(37) or blood deficiency(38), through increasing the production of blood(34) and moving the blood(37) for alleviating menstrual pain and cramps(39).

Spatholobus spp (Ji Xue Teng) also showed a protective effect against osteoarthritis (OA)(31), cancers(32)(33), fungal infection(34). inflammatory diseases(35),neurodegenerative disorders(36), etc.. in modern studies.

4. Ligusticum wallichi (Chuan Xiong)
Ligustium wallichi is also a herb for tonified blood circulation, including the abdominal region, used in Chinese medicine as reproductive system(42) enhancing herb throughunblock blood vessels(43), regulate menstruation(42).

Ligusticum wallichi (Chuan Xiong) also showed a protective effect in vasorelaxant activity(43); improved the Left Ventricular Ejection Fractionof central nervous system(44), against dementia(45)(49), atherosclerosis(46, renal tubule damage(47), inflammation(48), myocardial ischemic reperfusion(50), lens opacification(51), etc.. in modern studies.

5. Red sage roots (Dan Shen)
Red sage root is a main Chinese medicine used for treatment of blood stagnation(52) in the abdominal region by improving the blood circulation in the body including abdominal region and breaking up stagnation(52).

Red sage roots (Dan Shen) also showed a protective effect of CNS(56) and againstinjuries involving the cranium and intracranial structures (craniocerebral injury), degeneration of spinal disks in the neck (cervical spondylosis) and brain dysfunctions related to disease of the blood vessels (cerebrovascular diseases)(53), atherosclerosis(54),convulsant activit(55), hepatitis B(57), chronic fatigue syndrome (CFS)(58), benign prostatic hyperplasia (BPH)(59), etc. in modern studies.

Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Pregnancy Miracle
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References
(1) Ultrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: particle size effect by Choi KO1, Lee I, Paik SY, Kim DE, Lim JD, Kang WS, Ko S.(PubMed)
(2) Analgesic effect and mechanism of the three TCM-herbal drug-combination Tou Feng Yu pill on treatment of migraine by Li JC1, Shen XF, Meng XL, Zhang Y, Lai XR.(PubMed)
(3) Chinese Angelica Root(Eastern medicine export company)
(4) Immunomodulatory activity of polysaccharide isolated from Angelica sinensis by Yang T1, Jia M, Meng J, Wu H, Mei Q.(PubMed)
(5) [Therapeutic effect of Astragalus and Angelica on renal injury induced by ischemia/reperfusion in rats].[Article in Chinese] by Sheng MX1, Li JZ, Wang HY.(PubMed)
(6) [Adjustment effect of Radix Astragalus and Radix Angelicae sinensis on TNF-alpha and bFGF on renal injury induced by ischemia reperfusion in rabbit].

[Article in Chinese] by Xu XY1, Li LH, Wu LS, Zhao CL, Lin HY.(PubMed)
(7) Water-soluble polysaccharides from Angelica sinensis (Oliv.) Diels: Preparation, characterization and bioactivity by Sun Y1, Tang J, Gu X, Li D.(PubMed)
(8) [Structural analysis and anti-tumor activity in vivo of polysaccharide APS-2a from Angelica sinensis].[Article in Chinese] by Cao W1, Li XQ, Hou Y, Fan HT, Zhang XN, Mei QB.(PubMed)
(9) Experimental study of anti-tumor effects of polysaccharides from Angelicasinensis by Shang P1, Qian AR, Yang TH, Jia M, Mei QB, Cho CH, Zhao WM, Chen ZN.(PubMed)
(10) Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro: A Possible Mechanism to Promote Proteoglycans Synthesis by Qin J1, Liu YS, Liu J, Li J, Tan Y, Li XJ, Magdalou J, Mei QB, Wang H, Chen LB.(PubMed)
(11) Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity by Wen Y1, Li J2, Tan Y1, Qin J1, Xie X2, Wang L1, Mei Q3, Wang H4, Magdalou J5, Chen L6.(PubMed)
(12)Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease by Choi RC1, Zhu JT, Yung AW, Lee PS, Xu SL, Guo AJ, Zhu KY, Dong TT, Tsim KW.(PubMed)
(13) Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death by Zhu JT1, Choi RC, Chu GK, Cheung AW, Gao QT, Li J, Jiang ZY, Dong TT, Tsim KW.(PubMed)
(14) Isoflavones: chemistry, analysis, functions and effects on health and cancer by Ko KP.(PubMed)
(15) Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells by Chang CJ1, Chiu JH, Tseng LM, Chang CH, Chien TM, Wu CW, Lui WY.(PubMed)
(16) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(17)Medicinal plants as alternative treatments for female sexual dysfunction: utopian vision or possible treatment in climacteric women? by Mazaro-Costa R1, Andersen ML, Hachul H, Tufik S.(PubMed)
(18) The immediate effect of natural plant extract, Angelica sinensis and Matricaria chamomilla (Climex) for the treatment of hot flushes during menopause. A preliminary report by Kupfersztain C1, Rotem C, Fagot R, Kaplan B.(PubMed)

(19) Hemopoietic effect of extracts from constituent herbal medicines of Samul-tang on phenylhydrazine-induced hemolytic anemia in rats by Lee HW1, Kim H1, Ryuk JA1, Kil KJ2, Ko BS1.(PubMed)
(20) Characterization of the anti-influenza activity of the Chinese herbal plantPaeonia lactiflora by Ho JY1, Chang HW2, Lin CF3, Liu CJ4, Hsieh CF5, Horng JT6(PubMed)
(21) Anti-viral activity of water extract of Paeonia lactiflora pallas against human respiratory syncytial virus in human respiratory tract cell lines by Lin TJ1, Wang KC, Lin CC, Chiang LC, Chang JS.(PubMed)
(23) Paeoniflorin inhibited the tumor invasion and metastasis in human hepatocellular carcinoma cells by Lu JT, He W, Song SS, Wei W.(PubMed)
(24) Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway by Zhang J1, Dou W, Zhang E, Sun A, Ding L, Wei X, Chou G, Mani S, Wang Z.(PubMed)
(25) The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats by Tang NY1, Liu CH, Hsieh CT, Hsieh CL.(PubMed)
(26) Triglyceride accumulation: inhibitory effects of tangzhiqing formula by An Y1, Liu X, Qian Q, Zhang D, Li Y, Gao X, Zhang Y, Wang T.(PubMed)
(27) Paeoniflorin regulates macrophage activation in dimethylnitrosamine-inducedliver fibrosis in rats by Chen X1, Liu C, Lu Y, Yang Z, Lv Z, Xu Q, Pan Q, Lu L.(PubMed)
(28) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY1, Pan JQ, Lv JH.(PubMed)
(29) Wound-healing plants from TCM: in vitro investigations on selected TCM plants and their influence on human dermal fibroblasts and keratinocytes by Wang R1, Lechtenberg M, Sendker J, Petereit F, Deters A, Hensel A.(PubMed)
(30) Anxiolytic-like effect of paeonol in mice by Mi XJ1, Chen SW, Wang WJ, Wang R, Zhang YJ, Li WJ, Li YL.(PubMed)
(31) Water extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorption by

Hyunil Ha,1 Ki-Shuk Shim,1 Hyosun An,1 Taesoo Kim,

1 and Jin Yeul Ma(PubMed)
(32) Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint by Wang ZY1, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, Yang DP, Chow LW, Guan XY, Chen JP.(PubMed)
(33) Bioactivity-guided identification and cell signaling technology to delineate the lactate dehydrogenase A inhibition effects of Spatholobus suberectus on breast cancer by Wang Z1, Wang D, Han S, Wang N, Mo F, Loo TY, Shen J, Huang H, Chen J.(PubMed)
(34) A lectin from Spatholobus parviflorus inhibits Aspergillus flavus α-amylase: enzyme kinetics and thermodynamic studies by Tintu I1, Abhilash J, Dileep KV, Augustine A, Haridas M, Sadasivan C.(PubMed)
(35) Characterization of total phenolic constituents from the stems of Spatholobussuberectus using LC-DAD-MS(n) and their inhibitory effect on human neutrophil elastase activity by Huang Y1, Chen L, Feng L, Guo F, Li Y.(PubMed)
(36) Neuroprotective effects of formononetin against NMDA-induced apoptosis in cortical neurons by Tian Z1, Liu SB, Wang YC, Li XQ, Zheng LH, Zhao MG.(PubMed)
(37) Antiplatelet effects of Spatholobus suberectus via inhibition of the glycoprotein IIb/IIIa receptor by Lee BJ1, Jo IY, Bu Y, Park JW, Maeng S, Kang H, Jang W, Hwang DS, Lee W, Min K, Kim JI, Yoo HH, Lew JH.(PubMed)
(38) [Clinical observation of treating 62 patients with severe aplastic anemia failing in immunosuppressive therapy by integrative medicine].[Article in Chinese]by Su EY1, Fang YH, Chen HS.(PubMed)
(39) Backache and Chinese herbs(traditional Chinese medicine)
(40) Observation on the effects of Chinese medicine zhenxuanyin for improving cerebral blood flow in rats with cerebral ischemia by Jingyi W1, Yasuhiro M, Naoya H, Seok RC, Yoshiharu Y, Nagara T, Fumiko T, Shigeru M, Junji K.(PubMed)
(41) [Clinical and experimental study of Ligusticum wallichii and aspirin in the treatment of transient ischemic attack].[Article in Chinese] by Chen DR.(PubMed)
(42) Ligusticum wallichi (Chuan Xiong)(TCMWiki)
(43)Endothelium-independent vasorelaxation by Ligusticum wallichii in isolated rat aorta: comparison of a butanolic fraction and tetramethylpyrazine, the main active component of Ligusticum wallichii by Kim EY1, Kim JH, Rhyu MR.(PubMed)
(44) Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rat by Zhuo Yuan, 1 Junping Zhang, 1 ,* and Cui Yang(PubMed)
(45) Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson's disease induced by MPTP by Lu C1, Zhang J2, Shi X3, Miao S1, Bi L1, Zhang S4, Yang Q1, Zhou X1, Zhang M1, Xie Y1, Miao Q1, Wang S1.(PubMed)
(46) Study on anti-atherosclerotic effect of Suxiao Jiuxin Pill and its mechanism by Guo QX, Zhang J, Li YQ, Zhang GF.(PubMed)
(47) Ligustrazine attenuates elevated levels of indoxyl sulfate, kidney injury molecule-1 and clusterin in rats exposed to cadmium by Lan Z1, Bi KS1, Chen XH2.(PubMed)
(48) Prevention of inflammation-mediated neurotoxicity by butylidenephthalide and its role in microglial activation by Nam KN1, Kim KP, Cho KH, Jung WS, Park JM, Cho SY, Park SK, Park TH, Kim YS, Lee EH.(PubMed)
(49) Polyphenols and neuroprotection against ischemia and neurodegeneration by Lin B.(PubMed)
(50) Effect of Ligusticum wallichii aqueous extract on oxidative injury and immunity activity in myocardial ischemic reperfusion rats by Zengyong Q1, Jiangwei M, Huajin L.(PubMed)
(51) Protective effects and mechanism of tetramethylpyrazine against lens opacification induced by sodium selenite in rats by Li N1, Zhu Y, Deng X, Gao Y, Zhu Y, He M.(PubMed)
(52) Selection of component drug in activating blood flow and removing bloodstasis of Chinese herbal medicinal formula for dairy cow mastitis by hemorheological method by Lu Y1, Hu YL, Kong XF, Wang DY.(PubMed)
(53)The development of nao li shen and its clinical application by Lu SL1, Liu X, Wang JL, Ying Q, Hu SG, Hu PP, Zhu GP, Zhen HW, Bai YT, Wang Q.(PubMed)
craniocerebral injury), degeneration of spinal disks in the neck (cervical spondylosis) and brain dysfunctions related to disease of the blood vessels (cerebrovascular diseases)
(54) Effects of huoxue injection on the adherence of human monocytes to endothelial cells and expression of vascular cell adhesion molecules].[Article in Chinese]by Zhu LQ1, Wang SR, Qin Y.(PubMed)
(55) Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models by Buenafe OE1, Orellana-Paucar A, Maes J, Huang H, Ying X, De Borggraeve W, Crawford AD, Luyten W, Esguerra CV, de Witte P.(PubMed)
(56) Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice by Lam BY1, Lo AC, Sun X, Luo HW, Chung SK, Sucher NJ.(PubMed)
(57) [Study of xiaozhang recipe combined with lamivudine in treatment of 84 chronic viral hepatitis B patients with compensated liver cirrhosis][Article in Chinese] by Zhou ZH1, Li M, Huang LY.(PubMed)
(58) [Effect of lixu jieyu recipe in treating 75 patients with chronic fatigue syndrome].[Article in Chinese]

by Zhang ZX1, Wu LL, Chen M.(PubMed)
(59) [Clinical observation on ziyin tongbi decoction in treating benign prostatic hyperplasia][Article in Chinese] by Guo J1, Song CS, Han Q.(PubMed)

Overcome Infertility : Endometrial Lining Causes of Infertility

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.

Endometrial Lining Causes of Infertility

The endometrium is the inner membrane of the mammalian uterus. It helps to support the fertilized egg. Under influence of the high levels of estrogen at the early part of the menstrual cycle the endometrial lining become thick then become soft once ovulation occurs when progesterone is produced with high amount.
1. Adenomyosis
Adenomyosis happens most likely in the late of woman life and who has had several pregnancy. It is classified as a medical condition of endometrial cell grows within the muscular walls of the uterus causing symptoms similar to those of endometriosis. It may interfere with the embryo implantation if the uterine tissue extends through entire region of the uterine wall resulting in infertility and miscarriage.

2. Endometrial hyperplasia
Endometrial hyperplasia is defined as overgrowth or thickening of the uterus lining as resulting of high levels of estrogen and insufficient levels by of progesterone leading miss ovulation and infertility.

3. Endometriosis
Endometriosis is defined as cells of endometrium grow somewhere else other than in the endometrium. Normally, endometriosis not travel far but around the uterus region. It interferes with the ovulation and embryo implantation leading to infertility and miscarriage.

4. Endometritis
Endometritis is defined as infection or inflammation of the uterine lining caused by pelvic infection or sexual transmitting diseases leading to miscarriage for pregnant women.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

The Obesity' Research and Studies of Excess fruit juice consumption by preschool-aged children is associated with short stature and obesity

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of Excess fruit juice consumption by preschool-aged children is associated with short stature and obesity

In the study to evaluate, in a population-based sample of healthy children, fruit juice consumption and its effects on growth parameters during early childhood, Dr. Dennison BA, and the research team at the Mary Imogene Bassett Research Institute, Cooperstown found that Consumption of > or = 12 fl oz/day of fruit juice by young children was associated with short stature and with obesity. Parents and care takers should limit young children's consumption of fruit juice to less than 12 fl oz/day(1).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offe

(1) "Excess fruit juice consumption by preschool-aged children is associated with short stature and obesity" by Dennison BA, Rockwell HL, Baker SL.

Women Health: The Obesity and Infertility Research and Studies of Weight loss in obese infertile women

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of Weight loss in obese infertile women

Obesity affects ovulation, response to fertility treatment, pregnancy rates and outcome. In the study to to determine whether a weight loss programme could help obese infertile women, irrespective of their infertility diagnosis, to achieve a viable pregnancy, ideally without further medical intervention, posted in PubMed, found that women in the study lost an average of 10.2 kg/m2, with 60 of the 67 anovulatory subjects resuming spontaneous ovulation, 52 achieving a pregnancy (18 spontaneously) and 45 a live birth. The miscarriage rate was 18%, compared to 75% for the same women prior to the programme. Psychometric measurements also improved. None of these changes occurred in the comparison group. The cost savings of the programme were considerable. Prior to the programme, the 67 women had had treatment costing a total of A$550,000 for two live births, a cost of A$275,000 per baby. After the programme, the same women had treatment costing a total of A$210,000 for 45 babies, a cost of A$4600 per baby. Thus weight loss should be considered as a first option for women who are infertile and overweight.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Dietary Minerals: Potassium - The Effect on Hypertension

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Dietary Minerals

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

Potassium

In General, potassium is a very essential mineral to the human body for maintaining to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.

The Effect on Hypertension

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways.

The benefits
Administration of high potassium diets is found to be effective in lowering of blood pressure in some animal models of hypertension. Researchers suggested that the effect may be the result of diuretic action in reducing the extracellular fluid volume, thus decreased blood pressure. Others insisted that the lowering blood pressure of high potassium diet may enhance the potassium modifies central or the peripheral neural mechanisms that regulate blood pressure. In fact, increase fruit and vegetable intake such as banana, papaya, mango, spinach, tomatoes, etc., may help increase dietary potassium and reduce hypertension-related disease.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Role of dietary potassium in the treatment of hypertension by Treasure J, Ploth D.(PubMed)
(2) Potassium and fruit and vegetable intakes in relation to social determinants and access to produce in New York City by Loftfield E, Yi S, Curtis CJ, Bartley K, Kansagra SM.(PubMed)
(3) Endoscopic Removal of Pharmacobezoar in Case of Intentional Potassium Overdoseby Briggs AL, Deal LL.(PubMed)

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Overcome Infertility : Endometrial Lining Causes of Infertility

The Obesity' Research and Studies of Excess fruit juice consumption by preschool-aged children is associated with short stature and obesity

Women Health: The Obesity and Infertility Research and Studies of Weight loss in obese infertile women

Dietary Minerals: Potassium - The Effect on Hypertension