Sunday, August 21, 2016

Herbal therapy: Popular Herbal Schizandra

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                      
                                Schizandra


Schizandra is a shrub of the genus Schizandra, belonging to the family Schisandraceae, native to East Asia. The herb has been used in traditional medicine as adaptogen and sedative agent and to treat insomnia, irritation, palpitation, coronary heart disease, cognitive disorders, enhance immune system,reduce stress, etc.

Health Benefits 
1. Visceral hyperalgesia
In the investigation of the effect of Schisandra chinensis on visceral hyperalgesia induced by neonatal maternal separation (NMS) in an IBS rat model, found that S. chinensis can reverse visceral hypersensitivity induced by neonatal-maternal separation, and the effect may be mediated through colonic 5-HT pathway in the rat, according to "Schisandra chinensis reverses visceral hypersensitivity in a neonatal-maternal separated rat model" by Yang JM, Xian YF, Ip PS, Wu JC, Lao L, Fong HH, Sung JJ, Berman B, Yeung JH, Che CT.(1)

2. Immunomodulatory effects
In the evaluation of the immuno-modulating effect of a water-soluble polysaccharide named SCP-IIa of the fruit of Schisandra chinensis (Turcz.), using the immunosuppressed model induced by cyclophosphamide, found that SCP-IIa was involved in immunomodulatory effects leading to the exploration for SCP-IIa as a potential immunostimulant, according to "An immunostimulatory polysaccharide (SCP-IIa) from the fruit of Schisandra chinensis (Turcz.) Baill" by Chen Y, Tang J, Wang X, Sun F, Liang S.(2)

3. Antioxidant activity
In the identification of the chemical compounds of the essential oils of Schisandrachinensis seeds and berries without seeds extracts and their antioxidant effect found that the antioxidant activity of essential oil of berries without seeds (EOB) was higher than essential oil of seeds (EOS. The IC(50) values of EOB and EOS were 8.4 and 15.8 mg/mL, respectively. This study concluded that EOB and EOS were not only different in extraction yield but also in chemical composition and antioxidant activity, according to "Chemical composition and antioxidant activity of essential oil from berries of Schisandra chinensis (Turcz.) Baill' by Liu CJ, Zhang SQ, Zhang JS, Liang Q, Li DS.(3)

4. Anti-HIV-1
In the investigation of isolation of the fruits of Schisandra wilsoniana. The structures of 1-3 were elucidated by spectroscopic methods to determine their effects on HIV-1, found that compounds 1-3 were also evaluated for their anti-HIV-1 activities and showed bioactivity with EC(50) values of 3.26, 6.18, and 2.87 microg/ml, respectively, according to "Dibenzocyclooctadiene lignans from the fruits ofSchisandra wilsoniana and their anti-HIV-1 activities" by Yang GY, Li YK, Wang RR, Xiao WL, Yang LM, Pu JX, Zheng YT, Sun HD.(4)

5. Colon cancer
In the determination of Schizandra chinensis and its anti-cancer activity on colon carcinoma HCT-116 cells found that an active compound was found and identified to be Gomisin A. It displayed apoptotic activity through caspase-7 cleavage in colon carcinoma HCT-116 cells. In addition, we further assessed the effects of this compound using long-term survival clonogenic assay with HCT116 cells, according to "A compound isolated from Schisandra chinensis induces apoptosis" by Hwang D, Shin SY, Lee Y, Hyun J, Yong Y, Park JC, Lee YH, Lim Y.(5)

6. Leukemia
In the comparison of the pro-apoptotic effect of two dibenzocyclooctadiene lignans, gomisin A and gomisin N, isolated from Schizandra chinensis Baill, in U937 human promyelocytic leukemia cells in vitro, found that the cytotoxic effects and apoptotic characteristics induced by gomisin N were significantly inhibited by z-DEVD-fmk, a caspase-3 inhibitor, demonstrating the important role that caspase-3 plays in the process. We conclude that gomisin N induces the apoptosis of U937 cells through a signaling cascade of mitochondria-mediated intrinsic caspase pathways and gomisin N may be a useful chemotherapeutic agent, according to "Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill" by Kim JH, Choi YW, Park C, Jin CY, Lee YJ, Park da J, Kim SG, Kim GY, Choi IW, Hwang WD, Jeong YK, Kim SK, Choi YH.(6)

7. Cardioprotective effects
An aqueous extract of Schizandra chinensis (ScEx) was examined for its cardioprotective effects,
found that ScEx treatment restored endothelial function in rats that underwent balloon-induced carotid artery injury, and it reduced serum cholesterol levels in OVX rats. Similar to E2, ScEx exhibited hypotensive effects in OVX SHR. Therefore, ScEx and E2 exhibited similar cardioprotective effects, thereby suggesting that ScEx is a potential candidate to replace estradiol in the prevention and treatment of cardiovascular diseases, according to "Cardioprotective effects of aqueous Schizandra chinensis fruit extract on ovariectomized and balloon-induced carotid artery injury rat models: effects on serum lipid profiles and blood pressure" by Kim EY, Baek IH, Rhyu MR.(7)

8. Atopic Dermatitis
In the investigation of Schizandra chinensis Baillon (SC) and its effects on atopic dermatitis (AD) is an allergic inflammatory skin disease caused by aberrant and over-reactive immune responses, found that SCE lessened DNCB-induced histamine receptor mRNA expression in skin tissue and the splenic expressions of interleukin (IL)-4, IL-5, and high-affinity IgE receptor B protein. Conclusion: SCE appears useful for suppression of AD, even though the active pathway(s) remain unknown, according to "Inhibitory effects of Schizandra chinensis extract on atopic dermatitis in NC/Nga mice" by Kang YH, Shin HM.(8)

9. Relaxant effects
In the investigation schisandrin, schisandrol B, schisandrin A and schisandrin B, major lignans of Schisandra chinensis, and the ethanol extract contained higher amount of these lignans than the aqueous extract and theirs relaxant effect, found that schisandrin A also concentration-dependently inhibited ACh-induced contractions in Ca(2+)-free buffer. This study demonstrates that Schisandrachinensis exhibited relaxant effects on agonist-induced contraction in guinea pig ileum, with schisandrin, schisandrol B, schisandrin A and schisandrin B being the major active ingredients. The antispasmodic action of schisandrin A involved inhibitions on both Ca(2+) influx through L-type Ca(2+) channels and intracellular Ca(2+) mobilization, rather than specific antagonism of cholinergic muscarinic receptors, according to "Relaxant effects of Schisandra chinensis and its major lignans on agonists-induced contraction in guinea pig ileum" by Yang JM, Ip PS, Che CT, Yeung JH.(9)

10. Gastrointestinal effects
In the evaluation of the effects of Schisandra lignan extract (SLE) with short- and long-term pretreatment on regulating rat hepatic and intestinal CYP3A for a comprehensive evaluation of metabolism-based herb-drug interaction found that this study provides a comprehensive map for showing the complicated effects of SLE and its components on regulating rat CYP3A. The important findings are that SLE possesses a much stronger inducing than inhibiting effect on CYP3A, as well as a more intensive regulating effect on intestinal than hepatic CYP3A, according to "Effects of short-term and long-term pretreatment of Schisandra lignans on regulating hepatic and intestinal CYP3A in rats" by Lai L, Hao H, Wang Q, Zheng C, Zhou F, Liu Y, Wang Y, Yu G, Kang A, Peng Y, Wang G, Chen X.(10)

11. Cognitive function
In the Pretreating mice with schisandrin B (Sch B), an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, at a daily dose of 0.125-0.5 mmol/kg for 3 days protected against the THA/bis(7)-THA induced hepatic oxidative damage in a dose-dependent manner, found that Sch B treatment (0.025-0.5 mmol/kg/day x 5) also enhanced the passive avoidance-response in mice as assessed by the step-through task experiment. The ensemble of results suggests that Sch B may be useful for reducing the potential hepatotoxicity of THA/bis(7)-THA in anti-Alzheimer's therapy, according to "Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice" by Pan SY, Han YF, Carlier PR, Pang YP, Mak DH, Lam BY, Ko KM.(11)

12. Etc.

Side effects
1. Overdose may cause nervous depression
2. Overdose may cause gastrointestinal discomfort, such as stomach pain
3. Schizandra may cause allergic effect.
4. The herb may interact with other medication (a)
5. Etc.
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/22007516
(1) http://www.ncbi.nlm.nih.gov/pubmed/22230486
(2) http://www.ncbi.nlm.nih.gov/pubmed/22133665
(3) http://www.ncbi.nlm.nih.gov/pubmed/22103398
(4) http://www.ncbi.nlm.nih.gov/pubmed/20552486
(5) http://www.ncbi.nlm.nih.gov/pubmed/21903389
(6) http://www.ncbi.nlm.nih.gov/pubmed/20034537
(7) http://www.ncbi.nlm.nih.gov/pubmed/21256204
(8) http://www.ncbi.nlm.nih.gov/pubmed/21854164
(9) http://www.ncbi.nlm.nih.gov/pubmed/21764275
(10) http://www.ncbi.nlm.nih.gov/pubmed/19741040
(11) http://www.ncbi.nlm.nih.gov/pubmed/11914957


The Best Weight Loss and Healthy recipe: Pineapple-Banana Smoothie

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 15.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The (safe, nutritious, easy to prepare snacks for any occasion) ultimate allergy-free snack cookbook by Judi and Shari Zucker, Square one publishers. Over 100 kid -friendly recipes for the allergic child.

Frozen Fruit or Ice Cubes?

The foundation of any smoothie i fruit or fruit juice that is often thickened with ice.ice. Instead of ice, you can use frozen fruit. Either buy fruit that is already frozen or freeze your own fresh varieties. Wash the fruit well dry, and then place it in a zip-lock freezer bag. This is an especially good idea for berries, which are not always in season and spoil quickly. Frozen, they can last for months.

Yield: 2 serving (about 8 ounce each)
1 cup rice milk
1 medium-sized ripe banana, cut to small chunks
1/2 cup crushed pineapple
1 tablespoon honey or brown rice syrup
1-6 cubes

1. Place all the ingredients in a blend.
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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Dietary Minerals Boron: The effects of Boron supplementation on lean body mass, plasma testosterone levels

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                      Potassium

Boron, a vital trace mineral found abundantly in Almond, Red Apple, Apricots, Avocado, Banana, Red kidneyBeans, etc., is necessary for the normal growth and health of the body. Boric acid has antiseptic and antiviral activity. Its aqueous solutions have been used as mouth-washes, eye-drops, skin lotions and cosmetics.

       The effects of Boron supplementation on lean body mass, plasma testosterone levels

In the study to evaluate the effect of boron supplementation in 19 male bodybuilders ages 20-27 years. Ten were given a 2.5-mg boron supplement while 9 were given a placebo every day for 7 weeks. Plasma total and free testosterone, plasma boron, lean body mass, and strength measurements were determined on Days 1 and 49, found that 7 weeks of bodybuilding can increase total testosterone, lean body mass, and strength in lesser trained bodybuilders, and that boron supplementation had no effect on these measures(5).

Overcome Infertility: What Exhibits Cervical Conditions to Cause Infertility

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Overcome Infertility 

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.

       What Exhibits Cervical Conditions to Cause Infertility


1. Irregular cells growth
Irregular cells growth or forming of free radicals on the surface of the cervical canal as resulting of infection, inflammation or abnormal response to high levels of estrogen leading to heavy bleeding and obstruct the cervical opening causing infertility.

2. Birth defects
Cervical problems are caused by abnormal formation of cervix at birth may cause abnormal mucus production which is hostile to sperm invasion
a) Congenital problem
women who is pregnant but do not know that certain types of medication may interfere the cell division in the fetus leading to abnormal formation of cervix to the fetus which effects the mucus production..

b) Medical problem
Several abortions are the leading cause of cervical damage which increases the risk of adhesion in the cervix leading to abnormal function of cervix including cervix not open for sperm invasion or closed to allow pregnancy to proceed to term.

c) Estrogen problem
Women with low levels of estrogen a few days before and after ovulation may cause inability of cervix in production of cervical mucus which are friendly to sperm invasion.

3. Infection and inflammation
Women who have frequent cervicitis as resulting of inflammation or infection to the cervix may cause abnormal production of cervical mucus and reduce the chance to conceive.

4. Medication
Women who took dietthylstilbestrol to prevent miscarriage during pregnancy in the 50-60 may unknowingly increase the risk of deformities to the child reproductive organs including abnormal cervix.
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine



Children Health: Attention Deficit Disorder (ADHD/ADD) - Non Medical Treatments in conventional medicine prospective

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

           Attention Deficit Disorder (ADHD/ADD)

Attention Deficit Disorder (ADHD/ADD) also known as attention deficit hyperactivity disorder is a chronic disease occurs in certain age and years of a children, defined as a condition with characteristics of co-existence of attentional problems and hyperactivity. It effects about 5% of the all children in the world with boys have 3-4 times higher risk than girl. Over one third of children with ADHD will have continued symptoms existed into their adult life.


                 Non Medical Treatments

Cognitive behavioral therapy and medication may be at least partially helpful in the treatment of children with ADHD or with ASD, if it is not accompanied with diet and nutrition as in Children with Autism, researchers said, according to the study"Effectiveness of nutritional interventions on the functioning of children withADHD and/or ASD. An updated review of research evidence" by Martí LF., posted in PubMed(a)
2.1. Cognitive behavioral therapy
The aims of behaviour theory is to help the ADHD children to overcome the emotional, behavioural and cognitive dysfunction through a goal-oriented, systematic procedure. It is said that this types of treatment have proven to be successful in treating mood, anxiety, personality, eating, substance abuse, and psychotic disorders in some degrees.

2.2. Exercise
Research is demonstrating that acute exercise facilitated performance in the Stroop Test, particularly in the Stroop Color-Word condition. Additionally, children in the exercise group demonstrated improvement in specific WCST performances in Non-perseverative Errors and Categories Completed (10)

2.3. Parental Training
Parental Training in early alliance and change in alliance over time predicted improvements in several parenting behaviors and child outcomes, including peer sociometrics in a lab-based playgroup. These preliminary findings lend support to the importance of examining the parent-therapist alliance in parent-training groups for youth social and behavioral problems (11). Even though it is always difficult for parent to try them in the beginning, but be consistent. follow through on punishments and rewards. Keep rewards frequent and short-term, etc.

2.4. Occupational therapy
Occupational therapy is a type of program, helping to compromise physically, intellectually or emotionally to integrate coping skills into their lives in order to perform necessary tasks. but for children with ADHD, the main goal of occupational therapy is to integrate sensory perception through recognition and interpretation of sensory stimuli based chiefly on memory, therefore it helps the child to gain a more peaceful frame of mind and concentrate on certain tasks.

2.5. Social skill training
Social skill training plays an important role for many children with ADHD to learn social skills for improving relationships with peers for the child and formed part of the ADHD treatment.

2.6. Make Environment ADHD Friendly
Some researchers suggested that making environment friendly may be essential for children with ADHD such as reduce distractions and strategies for keeping attention for the ADHD children

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The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


Most Common Diseases of 50 Plus: Thyroid Disease : Thyroid hormone resistance syndrome – Treatments In conventional medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                         Thyroid disease


Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.


             Thyroid hormone resistance syndrome

Thyroid hormone resistance syndrome is defined as a condition of which affected individuals have elevated serum thyroid hormone levels and inappropriately normal or elevated thyroid-stimulating hormone (TSH) but are usually clinically euthyroid and require no treatment. Selective pituitary resistance to thyroid hormone (PRTH) is characterized by resistance in the pituitary gland but not in peripheral tissues(a).

                              The Treatments

in Conventional Medicine                                               
1. The table
Table. Suggested therapeutic approaches for resistance to thyroid hormone (RTH) patients.
___________________________________________________________________
Drugs Untoward effects and limitations
___________________________________________________________________
TRIAC Effective in almost all patients
D-T4 Effective in almost all patients
T3 Production of daily peaks of very high T3 concentrations, which
contribute to maintain clinical hyperthyroidism
Bromocriptine Transient effect owing to TSH escape from inhibition
Sms analog Transient effect owing to TSH escape from inhibition
Corticosteroid Cause of severe inhibition of hypothalamic-pituitary-adrenal axis function and cushingoid features
Antithyroid drugs Cause of further increase in TSH circulating level with consequent increase of goiter size and to hyperplasia at pituitary thyrotroph level
b-blockers Effects limited to b-adrenergic blockade. Propranolol inhibits peripheral conversion of T4 to T3, causing a worsening of tissue hypometabolic state. Cardiac selective compounds, such as atenolol devoid of effect on peripheral T4 conversion, appear to be more useful(31).
2. Limitation
According to the study by the Fitzsimons Army Medical Center, the thyroid hormone resistance syndromes are disorders in which the body’s tissues are resistant to the effects of thyroid hormone. Generalized resistance to thyroid hormone (GRTH) is characterized by resistance in the pituitary gland and in most or all of the peripheral tissues. Affected individuals have elevated serum thyroid hormone levels and inappropriately normal or elevated thyroid-stimulating hormone (TSH) but are usually clinically euthyroid and require no treatment. Selective pituitary resistance to thyroid hormone (PRTH) is characterized by resistance in the pituitary gland but not in peripheral tissues. Patients have elevated serum thyroid hormone levels and normal or elevated TSH levels and are clinically thyrotoxic. Therapy is usually necessary, but current choices are not completely satisfactory. Selective peripheral resistance to thyroid hormone (PerRTH) is characterized by resistance in peripheral tissues but not in the pituitary. The only patient thus far described had normal serum thyroid hormone and TSH levels but was clinically hypothyroid and improved with thyroid hormone administration. All of these disorders are probably more common than is generally recognized and are often misdiagnosed and inappropriately treated. GRTH, in most cases studied, results from a mutation in the thyroid hormone receptor beta gene causing an amino acid substitution in or a partial or complete deletion of the thyroid hormone-binding domain of the receptor. The causes of PRTH and PerRTH remain to be determined(32). Other studies indicated that in this age of rapidly advancing knowledge, it is reasonable to expect that the not too distant future will bring specific treatments for RTH. This will probably not be in the form of gene therapy as the dominant expression would require excision of the defective gene. The most simple genetic approach, one within the realm of current technology, is the selection of an oocyte from the affected mother that does not harbor the abnormal allele for in vitro fertilization followed by implantation into the donor. This insures a fetus without RTH but does not guarantee a normal pregnancy and fetal development. The development of TH agonists and antagonists that are TR-isoform specific would allow the stimulation or blockade of specific tissue effects that are perturbed in a given individual with RTH(33).

Women Health: The Obesity and Polycystic ovary syndrome Research and Studies of Metabolic dysfunction in polycystic ovary syndrome's interventions

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), resulting in male pattern hair development, acne,irregular period or absence of period, weight gain and effecting fertility. It effects over 5% of women population or 1 in 20 women.
The Studies of Metabolic dysfunction in polycystic ovary syndrome's interventions


Polycystic ovary syndrome (PCOS) is associated with metabolic disturbances including obesity, insulin resistance, diabetes and dyslipidemia. In the comprehensive clinical evaluation includes determination of body mass index, waist circumference, blood pressure and measurement of serum lipid and glucose levels in all women with PCOS and standard 2-h 75g oral glucose tolerance test is required for women with a body mass index over 25kg/m2 and with other risk factors for glucose intolerance. According to the study by the Hacettepe University School of Medicine, posted in PubMed, metformin improves insulin resistance without any effect on body mass index, fasting glucose or lipid levels. Short term use of statins alone or in combination with metformin decreases total cholesterol, low-density lipoprotein-cholesterol and triglycerides in PCOS patients with dyslipidemia. Low dose oral contraception in PCOS appears not to be associated with clinically significant metabolic dysfunction.