Medical Advisor Journals

Tuesday, August 23, 2016

Most Common Diseases of 50 Plus: Thyroid disease: Iatrogenic hypothyroidism

Thyroid is one of the largest endocrine glands found in the neck, below the Adam’s Apple with the function of regulating the body use of energy, make of proteins by producing its hormones as a result of the stimulation of thyroid-stimulating hormone (TSH) produced by the anterior pituitary.

Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.

Hypothyroidism is a condition in which the thyroid gland is under active and produces very little thyroid hormones. Thyroid cancer is defined as condition in which the cells in the thyroid gland have become cancerous.

Iatrogenic hypothyroidism

Iatrogenic hypothyroidism is defined as a condition of hypothyroidism as a result of treatments of over active thyroid, cancer, inflammation of the thyroid, etc., such as ablation (killing) with radioactive iodine, antithyroid medication, surgery to treat nodules, thyroid cancer, or an overactive thyroid gland, according to the Dr. Susan Wingo(1).

For more information of hypothyroidism, please visit The Section of hypothyroidism in the General health http://kylejnorton.blogspot.ca/p/general-health.html

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(48) http://www.ncbi.nlm.nih.gov/pubmed/20828316
(49) http://www.ncbi.nlm.nih.gov/pubmed/21030909
(50) http://www.ncbi.nlm.nih.gov/pubmed/20210607
(51) http://www.ncbi.nlm.nih.gov/pubmed/12528506
(52) http://www.ncbi.nlm.nih.gov/pubmed/20418062
(53) http://www.phcog.com/article.asp?issn=0973-1296;year=2010;volume=6;issue=21;spage=42;epage=50;aulast=Arulmozhi
(54) http://www.ncbi.nlm.nih.gov/pubmed/21247464

Women Health: The Obesity and Polycystic ovary syndrome Research and Studies of Hormonal profile, and metabolic abnormalities of obese women with polycystic ovary syndrome

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Children Health: Attention Deficit Disorder (ADHD/ADD) - Medical Treatments in conventional medicine prospective - Lisdexamfetamine (Vyvanse®)

Attention Deficit Disorder (ADHD/ADD) also known as attention deficit hyperactivity disorder is a chronic disease occurs in certain age and years of a children, defined as a condition with characteristics of co-existence of attentional problems and hyperactivity. It effects about 5% of the all children in the world with boys have 3-4 times higher risk than girl. Over one third of children with ADHD will have continued symptoms existed into their adult life.

Medical Treatments - Lisdexamfetamine (Vyvanse®)

Lisdexamfetamine (Vyvanse®)
c.1. Lisdexamfetamine dimesylate (LDX) is the medicine used in children with and without previous exposure to stimulant medication in the treatment of attention-deficit/hyperactivity disorder (ADHD) as a significantly less active form to dextroamphetamine. As LDX reduced the core symptoms of ADHD with more severe adverse events in stimulant-naïve than previous-exposure subjects. Future controlled studies with larger samples should address the impact of previous stimulant exposure on other ADHD treatments(25)
c.2. Side effects are not limit to
c.2.1. The medication can cause nervous tension, including mild irritability, nervousness, restlessness, dizziness, trouble sleeping, etc.
c.2.2. Lisdexamfetamine dimesylate can also cause digestive disorders, including, constipation, decreased appetite, diarrhea, dry mouth, nausea, stomach pain; vomiting, etc.
c.2.3. It may be subject to abuse cause as increased risk for impairment in driving behaviors.(26)
c.2.4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(25) http://www.ncbi.nlm.nih.gov/pubmed/22372513
(26) http://www.ncbi.nlm.nih.gov/pubmed/22277301

Children Health: Attention Deficit Disorder (ADHD/ADD) -Treatments In Nutritional Supplement perspective - Omega 3 fatty acid

Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(38) http://www.ncbi.nlm.nih.gov/pubmed/16962757
(39) http://www.ncbi.nlm.nih.gov/pubmed/22305186

General Health: Cirrhosis - Treatments In traditional Chinese medicine perspective

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Cirrhosis

Cirrhosis is defined as a condition of irreversible scarring liver as a result of liver tissue by fibrosis due to final phase of chronic liver diseases of that can lead to poor function of the liver and liver failure. According to the statistics, Number of discharges with chronic liver disease or cirrhosis as the first-listed diagnosis: 101,000 in 2009 and Deaths per 100,000 population: 10.3 in 2010(a). Hepatitis B infection cause of the disease is very prevalent in South-East Asia.

The Treatments

A. Treatments of cirrhosis depend not on the underline causes and stage of the diseases
Treatments In traditional Chinese medicine perspective
1. Yangyin Ruanjian decoction (HYRD)
In the study to explore the anti-fibrotic effect of Haobie Yangyin Ruanjian decoction (HYRD) on CCl(4)-induced hepatic fibrosis in rats and its modulation on the transforming growth factor (TGF) beta-Smad signaling pathway, by Tianjin Medical University, showed that HYRD can inhibit hepatic fibrosis induced by CCl(4) in rats, which is probably associated with its down-regulation on fibrogenic signal transduction of TGFbeta-Smad pathway(109).

2. JinSanE decoction
In the study to assess the effects of a Chinese herbal medicine, JinSanE decoction, on the TGF-beta1/Smads signal transduction pathway in a carbon tetrachloride (CCl(4))-induced hepatic fibrosis model in rats, conducted by the Wuhan University, indicated that compared with the hepatic fibrosis model group, the levels of TGF-beta1, TRII mRNA and Smad3 expression significantly decreased in the 2 treatment groups. The expression of Smad7 was significantly increased in the liver of the rats treated with JinSanE (p < 0.05 or p < 0.01). The histological changes of fibrotic liver were obviously improved in the treatment rats. The levels of liver HYP, serum liver function and HA were also remarkably improved in the treatment rats. Moreover, the effects of JinSanE occurred in a dose- and time-dependent manner in the process of the protection of liver injury and fibrosis. JinSanE decoction had a protective effect on liver injury and could ameliorate hepatic fibrosis in rats. The mechanisms might be associated with their effects of down-regulating TGF-beta1, TRII mRNA and Smad3, and up-regulating Smad7(110).

3. Kang'ai injection
In the study to investigate the inhibition role of Kang'ai injection (KAI) in rats with hepatic fibrosis, showed that Kang'ai injection could inhibit the formation of DEN-induced liver fibrosis(111).

4. Danshaohuaxian
The study of the effects of Danshaohuaxian (DSHX), a Chinese herbal recipe, on the apoptosis and cell cycles of hepatic stellate cells (HSCs) in rat hepatic fibrosisand its possible mechanisms, conducted by the Affiliated Hospital of Guiyang Medical College, indicated that DSHX capsule shows certain therapeutic effects on hepatic fibrosis in rats and inhibits abnormal deposition of COL(112)

5. Qianggan-Rongxian Decoction
Qianggan-Rongxian Decoction can inhibit hepatic fibrosis due to chronic liverinjury, delay the development of cirrhosis, and notably ameliorate liver function. It may be used as a safe and effective thera-peutic drug for patients with fibrosis, according to the study by the Affiliated Hospital of Chengde Medical College.

Sources
(a) http://www.cdc.gov/nchs/fastats/liverdis.htm
(109) http://www.ncbi.nlm.nih.gov/pubmed/20333785
(110) http://www.ncbi.nlm.nih.gov/pubmed/17163593
(111) http://www.ncbi.nlm.nih.gov/pubmed/23234152
(112) http://www.ncbi.nlm.nih.gov/pubmed/15641146
(113). http://www.ncbi.nlm.nih.gov/pubmed/18567088

Phytochemicals in Foods- The Effects of Theaflavin-3,3'-digallate

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Theaflavin-3,3'-digallate

Theaflavin-3,3'-digallate, a theaflavin derivative, is phytochemicals of Flavan-3-ols, in the group of Flavonoids (polyphenols) found abundantly in black tea.

Health Benefits
1. Antioxidant capacities
In the comparison of TF derivatives (theaflavin (TF(1)), theaflavin-3-gallate(TF(2)A), theaflavin-3'-gallate (TF(2)B), and theaflavin-3,3'-digallate (TF(3))) in scavenging reactive oxygen species (ROS) in vitro, indicated that positive antioxidant capacities of TF(2)B on singlet oxygen, hydrogen peroxide, hydroxyl radical, and the hydroxyl radical-induced DNA damage in vitro were found, according to "Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses" by Wu YY, Li W, Xu Y, Jin EH, Tu YY.(1)

2. Antimicrobial activities
In the evaluation of the antimicrobial activities of seven green tea catechins and four black tea theaflavins, found that (-)-gallocatechin-3-gallate, (-)-epigallocatechin-3-gallate, (-)-catechin-3-gallate, (-)-epicatechin-3-gallate, theaflavin-3, 3'-digallate, theaflavin-3'-gallate, and theaflavin-3-gallate showed antimicrobial activities at nanomolar levels; (ii) most compounds were more active than were medicinal antibiotics, such as tetracycline or vancomycin, at comparable concentrations; (iii) the bactericidal activities of the teas could be accounted for by the levels of catechins and theaflavins as determined by high-pressure liquid chromatography; (iv) freshly prepared tea infusions were more active than day-old teas; and (v) tea catechins without gallate side chains, gallic acid and the alkaloids caffeine and theobromine also present in teas, and herbal (chamomile and peppermint) teas that contain no flavonoids are all inactive, according to "Antimicrobial activities of tea catechins and theaflavins and tea extracts against Bacillus cereus" by Friedman M, Henika PR, Levin CE, Mandrell RE, Kozukue N.(2)

3. Edema, 4. anti inflammation
found that a single topical application of equimolar of black tea constituents (TF,theaflavin-3-gallate, theaflavin-3'-gallate, and theaflavin-3,3'-digallate) strongly inhibited TPA-induced edema of mouse ears. Application of TFs mixture to mouse ears 20 min prior to each TPA application once a day for 4 days inhibited TPA-induced persistent inflammation, as well as TPA-induced increase in IL-1beta and IL-6 protein levels. TFs also inhibited arachidonic acid (AA) metabolism via both cyclooxygenase (COX) and lipoxygenase pathways, according to "Inhibitory effects of black tea theaflavin derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and arachidonic acid metabolism in mouse ears" by Huang MT, Liu Y, Ramji D, Lo CY, Ghai G, Dushenkov S, Ho CT.(3)

5. Allergic effect
In the investigation of the preventive effects of black tea theaflavins, theaflavin-3-gallate (3-TF) and theaflavin-3,3'-digallate (TFDG), on oxazolone-induced type IV allergy in male ICR mice.
found that oral administration of 3-TF(theaflavin-3-gallate) and TFDG at a dose of 50 mg kg(-1) body weight prevented the increases in levels of some proinflammatory cytokines, interleukin-12 (IL-12), interferon-gamma (IFN-gamma), and tumour necrosis factor-alpha (TNF-alpha), according to "Preventive effects of black tea theaflavins against mouse type IV allergy" by Yoshino K, Yamazaki K, Sano M.(4)

6. Anti cancers
In the investigation of the inhibition effects of tea theaflavins complex (TFs),theaflavin-3-3'-digallate (TFDG), theaflavin-3'-gallate (TF2B), and an unidentified compound (UC) on the growth of human liver cancer BEL-7402 cells, gastric cancer MKN-28 cells and acute promyelocytic leukemia LH-60 cells, found that the inhibition effects of theaflavin-3'-gallate (TF2B), TFDG, and UC on BEL-7402 and MKN-28 were stronger than TFs. The relationship coefficients between monomer concentration and its inhibition rate against MKN-28 and BEL-7402 were 0.87 and 0.98 for TF2B, 0.96 and 0.98 for UC, respectively. The IC50 values of TFs, TF2B, and TFDG were 0.18, 0.11, and 0.16 mM on BEL-7402 cells, and 1.11, 0.22, and 0.25 mM on MKN-28 cells respectively, according to "The theaflavin monomers inhibit the cancer cells growth in vitro" by Tu YY, Tang AB, Watanabe N.(5)

7. Leukemia
in the investigation of the inhibitory effects of five tea polyphenols, namely theaflavin (TF1), theaflavin-3-gallate (TF2), theaflavin-3,3'-digallate (TF3), (-)-epigallocatechin-3-gallate (EGCG), and gallic acid, and propyl gallate (PG) on xanthine oxidase (XO) found that Tea polyphenols and PG all have potent inhibitory effects (>50%) on PMA-stimulated superoxide production at 20 approximately 50 microM in HL-60 cells. Gallic acid (GA) showed no inhibition under the same conditions. At 10 microM, only EGCG, TF3, and PG showed significant inhibition with potency of PG > EGCG > TF3, according to "Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate" by Lin JK, Chen PC, Ho CT, Lin-Shiau SY.(6)

8. Etc.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21887850
(2) http://www.ncbi.nlm.nih.gov/pubmed/16496576
(3) http://www.ncbi.nlm.nih.gov/pubmed/16404705
(4) http://www.ncbi.nlm.nih.gov/pubmed/20597096
(5) http://www.ncbi.nlm.nih.gov/pubmed/15248026
(6) http://www.ncbi.nlm.nih.gov/pubmed/10898615

Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Long Kui (Herb Solani nigri)

Long Kui (Herb Solani nigri)

Long Kui is also known Solanum Nigrum. The bitter, slightly sweet, cold and s toxic herb has been used in TCM as anti-pyretic, diuretic, anti cancers agent and to treat acute kidney inflammation, chronic bronchitis, etc., as it clears heat, eliminates toxins, invigorates blood, reduces swelling, promotes urination, etc., by enhancing the functions of lung, liver and stomach channels.

Ingredients
In the investigation to study of Nutraceuticals properties of Solanum nigrum and the results obtained compared with Chinese chive and Roselle plant, the seeds contain oil (36.5%), dietary fibre (1.3%) and crude protein (7%). Vitamin analysis in mg/kg (DW) indicated that seed contains thiamine (3.5), riboflavin
(1.8) and niacin (36.2). The most abundant fatty acids were linoleic (65.45%) and palmitic (10.19%) present in seeds. Seeds contain Fe (3.8), Ca (73) and Zn (14) in mg/100g (DW). The calorific value (kcal/100 g sample) for leaves (60.70); berries (73.98) and for seed (126.84). Anti nutritional factors in mg/100g (DW) for seeds were found at parity with Chinese chive and Roselle plants e.g. trypsin (1.01±0.74), phytic acid (0.13±0.32) and tannins (0.17±0.09) were moderate(a).

Health benefits
1. Antioxidant and antihyperlipidemic effect
In the study to evaluate the Solanum nigrum fruit extract (SNFEt) for its antioxidant and antihyperlipidemic activity against ethanol-induced toxicity in rats, in the lipid profiles, the levels of total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL), very low density lipoproteins (VLDL), free fatty acids (FFA), and phospholipids were significantly elevated in the ethanol-induced group, whereas, the high density lipoproteins (HDL) were found to be reduced in the plasma, and the phospholipid levels were significantly decreased in the tissues. Supplementation of SNFEt improved the antioxidant status by decreasing the levels of TBARS and altering the lipid profiles to near normal(1).

2. Hepatocarcinoma cell
In the searching for an effective agent against HCC progression, we prepared a polyphenolic extract of Solanum nigrum L. (SNPE), a herbal plant indigenous to Southeast Asia and commonly used in oriental medicine, to evaluate its inhibitive effect on hepatocarcinoma cell growth, found that found 1 µg mL(-1) SNPE-fed mice showed decreased tumor weight and tumor volume by 90%. Notably, 2 µg mL(-1) SNPE resulted in almost complete inhibition of tumor weight as well as tumor volume. In line with this notion, SNPE reduced the viability of HepG(2) cells in a dose-dependent manner. HepG(2) cells were arrested in the G(2)/M phase of the cell cycle; meanwhile, the protein levels of cell CDC25A, CDC25B, and CDC25C were clearly reduced.(2).

3. Prostate cancer
In the study to investigation of weather a polyphenolic extract derived from ripe berries of Solanum nigrum (SN) differentially causes cell cycle arrest and apoptosis in various human prostate cancer cells without affecting normal prostate epithelial cells, showed that SN treatment (5-20 µg/ml) resulted in a dose-dependent G2/M phase arrest and subG1 accumulation in the CA-HPV-10 but not in the PZ-HPV-7 cell line. Our results, for the first time, demonstrate that the SN extract is capable of selectively inhibiting cellular proliferation and accelerating apoptotic events in prostate cancer cells. SN may be developed as a promising therapeutic and/or preventive agent against prostate cancer.(3).

4. Estrogenic activity
In the study to evaluate the estrogenic potential of S. nigrum fruits by in vitro and in vivo assays, showed that At low concentration (40 μg/ml), SNGF induced a dose-dependent increase in MCF-7 cell proliferation, while higher extract concentrations (80-320 μg/ml) caused progressive cell growth inhibition. The competitive binding assay using ³H-E₂ suggests that this effect is mediated by estrogen receptor.(4).

5. Antiviral activity
In the study to search for anti-HCV plants from different areas of Pakistan, found that Methanol and chloroform extracts of Solanum nigrum (SN) seeds exhibited 37% and more than 50% inhibition of HCV respectively at non toxic concentration. Moreover, antiviral effect of SN seeds extract was also analyzed against HCV NS3 protease by transfecting HCV NS3 protease plasmid into liver cells(5).

6. Etc.

Side Effects
1. Do not use the raw fresh part of plant and unripe fruit as they are poisonous and can cause dilated pupils, dizziness, nausea, dry mouth and tongue, loss of ability to
talk, loss of consciousness.
2. Do not use the herb in case of spleen deficiency
3. 2. Do not use the Ling Kui in newborn, children or if you are pregnant or
breast feeding with out approval first with the related field specialist
4. Etc.